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8. RPA171824632018.Pdf 305 | P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 8(1): January-February 2019 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES IMPACT FACTOR 4.018*** ICV 6.16*** Pharmaceutical Sciences Review Article……!!! A REVIEW ON PHARMACOLOGY ACTIVITY OF CENTIPEDA MINIMA *Afrah jabeen & Utkarsh patle. Department of Pharmacognosy, Vijaya College of Pharmacy, Munganoor (V), Hayatnagar (M) R.R.Dist, 501511. KEYWORDS: ABSTRACT Centipeda minima, Methanol, Ether and aqueous extracts of Centipeda minima Sesquiterpene lactones , herbs having significant anti-allergy activities in cutaneous Phytochmeicals, Anti-allergy. anaphylaxis (PCA) test. Their are 3 flavonoids, 2 FOR CORRESPONDENCE: sesquiterpene lactones, and an amide were isolated from the AFRAH JABEEN * centipida minima plant material. It has to be induced ADDRESS: histamine release from mast cells of the tissue . The Department of Pharmacognosy, sesquiterpenes were identified as 6-O-isobutyroylplenolin Vijaya College of Pharmacy, and senecioylplenolin by spectral investigations. The Munganoor (V), Hayatnagar (M) flavonoids and sesquiterpenes having anti-allergy property in R.R.Dist, 501511. PCA test with p.o. administration. Full text available on www.ijupbs.com 306 | P a g e International Standard Serial Number (ISSN): 2319-8141 INTRODUCTION: Centipeda minima is an herb, often much branched from the base, it having stems size range between 8 - 20cm long, sometimes it may be 30cm long. Centipeda minima is an plant which are commonly used as a traditional medicinal plant.It is harvested from the wild for mainly local medicinal uses. Description: Chikkika- Centipeda minima is a plant used in Ayurveda for the treatment of rhinitis, headache, toothache, skin disease and indigestion. Synonyms Scientific Name :- Centipeda minima(L.) A.Br. & Asch. Common Name(s) :- English–Spreading Sneeze Weed. Synonym(s) :- Artemisia minima L. Latin name:- Centipeda minima Linn. Names in different languages: Hindi name- Nakachikani English name- Sneezewort, Spreading Sneezeweed Bengali name- Mechetha Gujarathi name- Nakacheenkani Marathi name- Nakashinkani Geographical Source: In Asia continent - China, Japan, India, Thailand, Indonesia and the Philippines to New Guinea, Australia and the Pacific Islands. Regional Habitat:- Frequently available along Nalas in moist and shady places. Distribution: Dungarpur, Jaipur, Bharatpur, Bhilwara, and Kota districts of Rajasthan. Habitat Humid open , banks of permanent waterholes, muddy banks of rivers, fallow rice-fields, very thinly grassed patches in the Savannah and wasteland at elevations from sea-level to 1,200 metres,sometimes to 2,400 metres. Cultivation Details The type of plant can be a weed of cultivated crops but it is considered to be a minor weed because it does not having deeply root, and it stays small. Full text available on www.ijupbs.com 307 | P a g e International Standard Serial Number (ISSN): 2319-8141 Parts use Leaves, Seeds. Medicinal Properties Anti-inflammatory, anti-allergic, sunscreen and cell renewal. The plant has an alternate Latin name as Centipede orbicularis Laur. Chikkika is an small plant which are growing all over India in the damp areas. The plant is commonly native of Australia and Newzeland. Centipeda minima – medicinal properties: Rasa (Taste) – Katu (Pungent) Guna (Qualities) – Teekshna (Hot) Veerya (Potency) – Ushna (Hot) Vipaka – Katu (It Undergoes Pungent taste after the process of digestion) Karma (Actions) – Kapha Vata shamaka (It use reduces vitiated kapha and vata dosha). It Increases Pitta Dosha. Dosage- Powder of seed 1-3 g. Chemical constituents of Spreading Sneezeweed. The plant contains flavonoids, sesquiterpenes and amide. Ayurvedic uses of Chikkika: Ruchikrut – improves taste, relieves anorexia Agnikrut – Improves digestion strength Pittakrut – Increases Pitta Dosha Indicated in Eye disorders Kapha and Vata Disorders Kushta – skin diseases Krimi – worm infestation Vatarakta – Gout Uses of Chikkika – Centipeda minima Nasal drops are prepared from the leaves of the plant centipede minima is done use to relive the condition of sinusitis and headache. The paste is use to prepared from the seeds of the plant Centida minima is applied externally for the treatment of skin diseases like ringworm, scabies etc. Full text available on www.ijupbs.com 308 | P a g e International Standard Serial Number (ISSN): 2319-8141 The crumble of the seed is given in a dose of 2-3 g with milk to improve the strength of the nerves and treat general debility. The powder which are obtain from the seeds of Centida minima is given in a dose of 2-4 g to treat erectile dysfunction. The cold infusion which are prepared from the seeds of Chikkika is given in a dose of 20-30 ml to treat indigestion and lack of appetite. In cases of the hardness of the liver and spleen, the decoction of the plant is given regularly. The paste prepared from the leaves of the plant is applied over the area affected by pain. The adverse effect of Chikkia Excessive use of Chikkika causing side-effects like inflammation of the nasal mucosa and pain in the nose. Research and biological activities Volatile oils extracted from the plant of Centipeda minima having an anti-inflammatory action. thr action of centipida minima is due to the inhibiting inflammatory cytokines in a rat model.[11] In a related study, C. minima eased allergic rhinitis by slowing the infiltration of eosinophils and the proliferation of mast cells.[12] Biological activity of the centipida minima shows that the species' exist for the extraction contains novel compounds that having an anti-inflammatory and antioxidant properties.[13] Antimicrobial action The present study is designed for phytochemical analysis of Centida minima and extraction of the bioactive compound by HPLC, a further antimicrobial activity of the bioactive compounds has been investigated by crude extract and the column extract and antiproliferative activity on prostate epithelial cancer cell (PC3). Our study revealed the presence of the bioactive component phenolic of this plant has good antimicrobial activity and also exhibiting anti-cancer properties. Anti-protozoal action In vitro activity against Giardia lamblia was used for bioassay-guided fractionation of crude extracts from C. minima. sesquiterpene lactone was Similarly active in vitro against Entamoeba histolytica (IC50 between the tange of 4.5 and 9 μM) and also it use against plasmodium falciparum ((IC50 = 9.42 μM). Acknowledgements: Authors are thankful to the faculty members of Vijaya College of Pharmacy. Full text available on www.ijupbs.com 309 | P a g e International Standard Serial Number (ISSN): 2319-8141 REFERENCES: 1. a b Flann, C (ed) 2009 . 2. Loureiro, João de. 1790. Flora cochinchinensis: sistens plantas in Regno Cochinchina nascent. Quibus accedunt aliae observatae in Sinensis imperio, Africa Orientali, Indiaeque locis variis. 3. Tropicos, Centipeda Lour. 4. Botanic Garden and Botanical Museum Berlin-Dahlem. "Details for Astereae". Euro+Med PlantBase. Freie Universität Berlin. Retrieved 2009-07-18. 5. UniProt. "Tribe Astereae". Retrieved 2009-07-18. 6. National Herbarium of New South Wales. "Genus Centipede". New South Wales FloraOnline. Royal Botanic Gardens, Sydney. Retrieved 2013-06-17. 7. Flora of China Vol. 20-21 Page 892 8. Qin, R. A.; et al. (2005). Zhongguo Zhong Yao Za Zhi. 30 (15): 1192–4. PMID 16201699. 9. Liu, Z. G.; et al. (2005). "Histopathological study on allergic rhinitis with Centipeda minima". Zhongguo Zhong Yao Za Zhi. 30 (4): 292–4. PMID 15724411. 10. Beattie, Karren D. (2009).PhD thesis. Southern Cross University. 11. Liu, Z. G.; et al. (2005). "Histopathological study on allergic rhinitis with Centipeda minima". Zhongguo Zhong Yao Za Zhi. 30 (4): 292–4. PMID 15724411. 12. Beattie, Karren D. (2009). "Phytochemical studies and bioactivity of Centipeda and Eremophila species". PhD thesis. Southern Cross University. 13. Nylinder, Stephan (Apr 2, 2013). "Species tree phylogeny and character evolution in the genus Centipeda (Asteraceae): Evidence from DNA sequences from coding and non-coding loci from the plastid and nuclear genomes". Molecular Phylogenetics and Evolution. 68: 239–250. Full text available on www.ijupbs.com .
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