DOCSLIB.ORG

Convalescent Plasma in Critically Ill Patients with Covid-19

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Convalescent Plasma in Critically Ill Patients with Covid-19 Convalescent Plasma in Critically Ill Patients with Covid-19 The REMAP-CAP Investigators Supplementary Appendix Table of Contents Convalescent Plasma in Critically Ill Patients with Covid-19 ..................................................................... 1 1. REMAP-CAP investigators and collaborators .................................................................................... 3 REMAP-CAP Trial Investigators & Collaborators ................................................................................................ 3 International Trial Steering Committee:.................................................................................................................................... 3 Regional Management Committees .......................................................................................................................................... 3 Regional Coordinating Centers .................................................................................................................................................. 4 Domain-Specific Working Groups ............................................................................................................................................. 4 Statistical Analysis Committee .................................................................................................................................................. 7 Statistical Design Team.............................................................................................................................................................. 7 Project Management ................................................................................................................................................................. 7 Data and Safety Monitoring Board ............................................................................................................................................ 8 Database Providers.................................................................................................................................................................... 8 Site Investigators and Research Coordinators........................................................................................................................... 8 Clinical Trials Groups ............................................................................................................................................................... 30 Blood Transfusion Services ............................................................................................................................. 31 Australia .................................................................................................................................................................................. 31 Canada ..................................................................................................................................................................................... 31 New Zealand ............................................................................................................................................................................ 33 United Kingdom ....................................................................................................................................................................... 33 United States Blood Transfusion Services ............................................................................................................................... 35 Sample reception, processing, storage and testing laboratories....................................................................... 35 Australia .................................................................................................................................................................................. 35 Canada ..................................................................................................................................................................................... 36 United Kingdom ....................................................................................................................................................................... 36 2. Supplementary methods ............................................................................................................... 38 Patient eligibility criteria ................................................................................................................................ 38 Platform eligibility (Pandemic appendix to the core protocol) ............................................................................................... 38 Immunoglobulin Domain eligibility ......................................................................................................................................... 38 Definition of Moderate and Severe States ...................................................................................................... 39 Definition of Immunodeficiency ..................................................................................................................... 39 Definition of per protocol ............................................................................................................................... 40 Collection and distribution of convalescent plasma ......................................................................................... 40 Australia .................................................................................................................................................................................. 40 Canada ..................................................................................................................................................................................... 41 United Kingdom ....................................................................................................................................................................... 41 United States ........................................................................................................................................................................... 42 Measurement of participant baseline SARS-CoV-2 serostatus .......................................................................... 43 Australia .................................................................................................................................................................................. 43 United Kingdom ....................................................................................................................................................................... 43 United States ........................................................................................................................................................................... 44 Measurement of participant baseline SARS-CoV-2 PCR status ......................................................................... 44 United Kingdom ....................................................................................................................................................................... 44 Treatment allocation and interventions .......................................................................................................... 44 Available Interventions............................................................................................................................................................ 44 Convalescent plasma at randomization .................................................................................................................................. 44 No immunoglobulin to SARS-CoV-2 (control) .......................................................................................................................... 45 Delayed convalescent plasma ................................................................................................................................................. 45 Secondary outcomes ...................................................................................................................................... 45 REMAP-CAP Core Protocol Secondary Outcomes: .................................................................................................................. 45 Immunoglobulin Domain Secondary Outcomes...................................................................................................................... 46 Secondary Outcomes prespecified in Statistical Analysis Plan ................................................................................................ 46 3. Supplementary figures .................................................................................................................. 47 Figure S1 ........................................................................................................................................................ 47 Figure S2 ........................................................................................................................................................ 48 4. Supplementary Tables ................................................................................................................... 49 Table S1. Participant Characteristics at Baseline* ............................................................................................ 49 Table S2. Randomisation into
Load more

Recommended publications
  • A CHRISTMAS CAROL an Actor Friend of Mine Said Once That All Directors Are Either Mechanics Or Gardeners
    A CHRISTMAS CAROL an actor friend of mine said once that all directors are either mechanics or gardeners. A mechanic solves problems so that the machine works; a gardener creates the conditions in which something can grow. Some of the most vital jobs at The Shaw require mechanics; but to direct our plays, I want gardeners. What does this mean for the process or result of our work? It means a process in which rehearsals are playful and exploratory. It means that we don’t try to nail down the ‘right’ version of a scene; we play inside it and allow it to reveal itself – over the course of a whole season. And the result? Well, the thing about gardening is that there is no result. A beautiful tree may appear, but it will not be fin- ished. It will keep growing and, with love and care, it will simply get more and more beautiful with time. This is the garden we will be FESTIVAL THEATRE Me and My Girl • creating, together with you. Saint Joan • Dracula COURT HOUSE Your imagination and your THEATRE 1837: The Farmers’ Revolt • passion will be the sun and Androcles and the Lion • Wilde Tales rain without which there is no life. Thanks to you, our work ROYAL GEORGE THEATRE The Madness of will grow, and it will change. George III • Dancing at Lughnasa So you really need to see • An Octoroon • A Christmas every show more than once. Carol JACKIE MAXWELL STUDIO THEATRE tim carroll, Middletown VARIOUS VENUES 1979 artistic director 1-800-511-7429 SHAWFEST.COM niagara-on-the-lake’s most critically acclaimed restaurant and wine bar Gluten-free cones ORGANIC Specialty coffees, Gelato pastries GELATO Dairy-free sorbetto FROM ITALY Organic cane sugar Handcrafted locally Non-GMO ingredients 114 Queen Street Niagara-on-the-Lake 59 queen street – Open until 11:30pM (next to Starbucks) 905.468.8999 gelatodicarlotta.com treadwellcuisine.com yOur ticket stub = 10 % Off 905-934-9797 alsO visit us at fallsview casinO and vauGhan Mills shOppinG centre GIVE THE GIFT OF THEATRE THIS HOLIDAY! A SHAW GIFT CERTIFICATE IS ALWAYS IN SEASON.
    [Show full text]
  • Sporting Legends Gala Dinner an Evening with Aggers
    15 Abchurch Lane, London, EC4N 7BW In association with Sporting Legends Gala Dinner An Evening with Aggers Wednesday 31st October 2012 Jonathan Agnew Join Jonathan Agnew, the former Leicestershire & England cricketer and stalwart of Test Match Special, for an evening of fine food, drink and chat about the glorious game. A fine fast bowler in his day, Aggers’ best first-class bowling figures were 9 for 70 and he took six ten-wicket hauls in 218 matches. During the 1980’s Jonathan Agnew played three Test Matches and three One Day Internationals for England before taking up his position in the commentary box. In 1987, Agnew began work with BBC Radio Leicester. He retired at the end of the 1990 season to become chief cricket writer of the Today newspaper, and was appointed BBC Cricket Correspondent at the start of the 1991 season. Agnew made his ball-by-ball commentary debut for the final Test of the 1991 season. He was also the catalyst to Brian Johnston's infamous fit of the giggles after Ian Botham was out hit wicket - after failing to get "his leg over" which has been voted "the greatest piece of sporting commentary ever" in a BBC poll. Jonathan Agnew is now one of the mainstays of Test Match Special, writes regularly for the BBC Sport website and has written a number of cricketing books. Tickets: £85 each for LCC Members / £100 each for non-members Tables of 11 – shared or group bookings available Price includes a sumptuous 3-course meal & half-a-bottle of wine per person Auction of signed memorabilia, with selected lots in support of the charity ‘Futures For Kids’ Dress: Lounge Suits Meet in @15 Bar & Restaurant from 6:30pm – seated for dinner in the Oriental Room for 7pm To book your place at this event or for general enquiries please contact: [email protected] or 0207 717 0088 .
    [Show full text]
  • Cricket and Broadcasting Review
    Richard Haynes (2012): Cricket and Broadcasting, Sport in History, 32:3, 460-463 Jack Williams, Cricket and broadcasting. Manchester University Press, 2011, 240p, HB 978-0719-0-7748-7. The relationship between cricket and broadcasting has been written about more than any other form of mediated sport. This is partly because the sport enjoys a voluminous catalogue of memoir, biography, journalism and analysis, much of which has been written by former players turned broadcasters, or journalists who also ply their trade in radio or television. There have also those from within broadcasting, such as Brian Johnston, John Arlott and Peter Baxter, who over the years have shared their insights on commentary and the peculiarities in production of cricket broadcasting. In spite of this literature, there has not been a detailed academic history of cricket and broadcasting, which is why Jack Williams’ new book in the Studies in Popular Culture series by Manchester University Press is most welcome. Cricket and broadcasting brings together much of the literature on the subject with archival evidence and interviews with those who have made this field of broadcasting a much treasured aspect of British popular culture. Williams makes a compelling argument for a need to develop a detailed study of the relationship between cricket and broadcasting in order to understand how radio, and then television, transformed the sport. Furthermore, in concentrating on how cricket has been covered by both forms of media, it is possible to shed light on how the sport is understood by the public, as editors, producers and commentators frame and shape both our consumption and knowledge of cricket.
    [Show full text]
  • Cricket Books for Sale
    CRICKET BOOKS FOR SALE PICK ANY TEN BOOKS FROM LIST BELOW FOR £30 , OR ANY FIVE FOR £20 All books are hardback and in very good condition. Contact Steve Smith 07779 151985 or email [email protected] BIOGRAPHIES Gary Sobers – Twenty Years at the top Peter May – A Game Enjoyed Plum Warner – by G. Howat The Life of C.B.Fry – C.Ellis Ray Illingworth – Yorkshire and Back Geoffrey Boycott – In the Fast Lane ( 1981 W.Indies ) Geoffrey Boycott – Opening Up ( 1979/80 Australia ) Gubby Allen – Man of Cricket Fred Trueman – Then and Now – Don Mosey Basil D’Oliveira – Time to Declare Imran Khan – All Rounder Botham – My Autobiography Botham – Patrick Eagar Gooch - My Autobiography Chris Broad – Home Truths From Abroad John Emburey – Spinning in a Fast World Joel Garner - Flying High Malcolm Marshall – Marshall Arts Alan Border - A Peep at the Poms David Gower – With Time to Spare Keith Miller – Cricket from the Grandstand Alfred Mynn & Cricketers of his Time – P. Morrah Mike Proctor & Cricket HISTORIES From The Sea End – Official History of Sussex CCC – C. Lee The Official History of Yorkshire CCC – D. Hodgson The History of Gloucestershire CCC – D. Green Nottinghamshire – Cricket Double Champions 1987 – P. Wynne-Thomas The Story of Middlesex CCC – Anton Rippon Summer of Success , Essex CCC 1979 – D. Lemmon A History of Cricket – Benny Green Wisden Book of Cricketers Lives – Benny Green Wisden Anthology 1963 – 1982 Benny Green Wisden Book of One Day Internationals 1971 – 1985 The Ashes – A Centenary . – Ray Illingworth & K. Gregory The Ashes Captains 1882 – 1988 , - G. Cotter England v New Zealand, A History - G.
    [Show full text]
  • LARGE COLLECTION of CRICKET BOOKS for SALE I Am Helping a Family Dispose of a Large Collection of Cricket Books
    LARGE COLLECTION OF CRICKET BOOKS FOR SALE I am helping a family dispose of a large collection of cricket books. Over 3,500!!!! This is just a small part of it. They are mainly published after the Second World War, and all the books have been published over the last 60 years. No names are written inside and the books are in excellent condition. Page | 1 Most books are priced between £3-£5 and can be posted (extra cost). Postage: £1.00p per book (for hardbacks & large paperbacks) small paperbacks 50p. All the books are in excellent condition and have original dust-wrappers and can be bought via cheque made payable to: Max Books. Address: 34 Wellington Road, Nantwich, Cheshire CW5 7BX. NB Please e-mail before sending any cheques in case the book(s) you wish to buy have already been sold. Please e.mail to order the books. Large orders (10 books or more) we will negotiate on postage. E-mail: [email protected] 1. HISTORY OF THE GAME * Arlott A readers Guide to Cricket. Pamphlet. £4. * Ashley Mote. The Glory Days of Cricket. - 1997. D/W/ as new. £5.(2) * Derek Birley Social History of English cricket. h.b d.w . 1999. £6 (2). ** Derek Birley. The Willow wand.h.b.d.w.£4. **Rowland Bowen. Cricket Hist. of its growth & development.1970 H.b. nice d.w £7. ** Chris.Brookes. The game ands its players through the ages. H.b.d.w £4. * P.Donnelly. First’s lasts & Onlys. 2010. H.b.d.w. £3. * Dunlop Cricketer’s Companion-Jack Cross .1976.
    [Show full text]
  • Dr. Michael M. Chemers Assistant Professor of Dramatic Literature 335 PCA 412.268.2399 [email protected]
    DRAMA 54-520 A SLIDE GLIDE IN CONTEXT 3 Credits Primary Instructor: Dr. Michael M. Chemers Assistant Professor of Dramatic Literature 335 PCA 412.268.2399 [email protected] Meeting info: TH 6:30-7:20 February 3-April 7 (please see schedule below) Adamson Wing, Baker 136 A Office Hours: By appointment COURSE DESCRIPTION SLIDE GLIDE THE SLIPPERY SLOPE is a theatrical piece running in repertory as part of Carnegie Mellon’s 2004-5 Drama season Feb 28 to Mar 3, and again Mar 14-26. The theme for this year’s season is “Art is Science made clear”. This pass/fail, 3-credit course is built around the play. Students will engage in a “deep read” of this provocative text in cultural, political, and scientific contexts. Eight lectures by experts in different fields from across the disciplines will discuss the salient issues of the play. A short reading may be required for each lecture. Students will be required to write a final paper. COURSE OBJECTIVES Upon successful completion of this mini course, the student will be able to: • Demonstrate a unique comprehensive understanding of the dramatic and scientific issues raised by the play. • Develop and apply several methods for evaluating the use of science in drama. • Execute a critical analysis of a dramatic text within a larger socio-scientific context. • Conceive, research, and write documented, balances, and informed historical analyses of dramatic texts, performances, or periods of theatre history. • Identify ethical issues raised in connection with scientific progress. REQUIRED TEXTS Slide Glide, The Slippery Slope by Kia Corthron.
    [Show full text]
  • Broadcasting and Cricket in England
    4 JACK WILLIAMS Broadcasting and cricket in England No survey of cricket in England since the Second World War would be com- plete without a discussion of its relationship with broadcasting. Radio and television have provided instantaneous reporting of top-level cricket. The leading commentators have been among the game’s star personalities and, while most have specialised in one medium, they have usually worked in both radio and television. The BBC has always dominated radio coverage of cricket and had a near monopoly of televised cricket until the 1990s. But radio and television have presented differing images of cricket and have had different impacts on its organisation and fi nances. Radio has done more to refl ect the traditional atmosphere of cricket while television has done more to stimulate change in cricket. The scale of cricket broadcasting The scale of cricket broadcasting has reinforced cricket’s standing as one of England’s leading sports. Given the relatively small numbers who attend matches, one can argue that broadcasting has exaggerated the signifi cance of cricket. BBC radio match coverage started in 1927 and by the end of the 1930s it broadcast cricket for more hours than any other sport. Since the start of Test Match Special ( TMS ) in 1957, which has provided live commentary on every ball of Test matches played in England, cricket has probably been the sport broadcast for most hours on national radio, while local radio also has extensive coverage. The BBC coverage of the England– Australia Test at Lord’s in 1938 was the fi rst cricket match broadcast by television anywhere in the world.
    [Show full text]
  • JW Mckenzie Cricket Books
    J.W. McKenzie 12 Stoneleigh Park Road, Ewell, Epsom, Surrey, KT19 0QT England Tel: 020 8393 7700 E-mail: [email protected] Website: www.mckenzie-cricket.co.uk Our shop has eight rooms filled with old and rare cricket books, autographs, prints and other cricket memorabilia. BY CAR: We are close to central London, just off the A240, not far from the Tolworth junction on the A3. Alternatively, if travelling via the M25 leave at Junction 8 and follow the signs to Kingston. There is parking outside the shop. BY TRAIN: Trains run every 15 minutes from London Waterloo and Clapham Junction to Stoneleigh Station. (After leaving the platform at Stoneleigh Station turn right at the top of the steps). The shop is a short walk down-hill from the station. We are open: Monday to Thursday 9 am to 5 pm Friday 9 am to 4.30 pm Saturdays by appointment Please contact us before visiting. CONTENTS Cricket books 1 Wisden Cricketers’ Almanacks 1213 Individual Autographs 1276 Autograph Sheets 1359 Chevallier Tayler 1368 Photographs 1392 Cricketana 1422 Cigarette Card Sets 1469 ACCEPTED METHODS OF PAYMENT Cheque: (made out to J W McKenzie) Credit/Debit cards: over the telephone Bank Transfer: CAF Bank Ltd. Account name J W McKenzie Ltd. Account No. 00050166 Sort Code 40-52-40 IBAN: GB92CAFB40524000050166 SWIFT/BIC: CAFBGB21(Please let us know when a transfer has been arranged) Paypal: Please log into your Paypal account and use our email address [email protected] All prices are net. Postage is extra, charged at cost. All items are sent fully insured.
    [Show full text]
  • Cricket and Broadcasting, Sport in History, 32:3, 460-463
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Stirling Online Research Repository Richard Haynes (2012): Cricket and Broadcasting, Sport in History, 32:3, 460-463 Jack Williams, Cricket and broadcasting. Manchester University Press, 2011, 240p, HB 978-0719-0-7748-7. The relationship between cricket and broadcasting has been written about more than any other form of mediated sport. This is partly because the sport enjoys a voluminous catalogue of memoir, biography, journalism and analysis, much of which has been written by former players turned broadcasters, or journalists who also ply their trade in radio or television. There have also those from within broadcasting, such as Brian Johnston, John Arlott and Peter Baxter, who over the years have shared their insights on commentary and the peculiarities in production of cricket broadcasting. In spite of this literature, there has not been a detailed academic history of cricket and broadcasting, which is why Jack Williams’ new book in the Studies in Popular Culture series by Manchester University Press is most welcome. Cricket and broadcasting brings together much of the literature on the subject with archival evidence and interviews with those who have made this field of broadcasting a much treasured aspect of British popular culture. Williams makes a compelling argument for a need to develop a detailed study of the relationship between cricket and broadcasting in order to understand how radio, and then television, transformed the sport. Furthermore, in concentrating on how cricket has been covered by both forms of media, it is possible to shed light on how the sport is understood by the public, as editors, producers and commentators frame and shape both our consumption and knowledge of cricket.
    [Show full text]
  • Wrappers. Reading Copy. ALLEN David Rayvern. BIRD Dickie. BIRD Dickie. BRADMAN Don. CREEK F.N.S. SOLD
    1. ALLEN David Rayvern. Another word from Arlott. Guild 1985. d/w. A further collection of John Arlott’s broadcasts, cricket commentaries and writings. Very good. £2.50 2. BATCHELOR Denzil. THE MATCH I REMEMBER. Werner Laurie 1950. First Edition. d/w. Essays about 11 matches from the lips of players such as Hobbs, Sutcliffe and Tate. Reading copy only. £1.00 3. BIRD Dickie. MY AUTOBIOGRAPHY. Hodder & Stoughton 1997. First Edition. d/w. Very good. £3.00 4. BIRD Dickie. MY AUTOBIOGRAPHY. Coronet 1998. Original wrappers. Updated edition. Reading copy. £1.00 5. BOTHAM Ian. BOTHAM MY AUTOBIOGRAPHY. Collins Willow 1995. Original wrappers. Including new chapter. Reading copy. £1.00 6. BOYCOTT Geoffrey. THE AUTOBIOGRAPHY. Corgi Books 1988. Original wrappers. Reading copy. £1.00 7. BRADMAN Don. HOW TO PLAY CRICKET. Daily Mail 1948. Original wrappers but with facsimile covers. Good. £1.50 8. CHALKE Stephen. ONE MORE RUN. Fairfield 2000. First Edition. Original wrappers. Stephen Chalke talking with Bryan ‘Bomber’ Wells. Gloucestershire versus Yorkshire, Cheltenham, August 1957. As new. £4.00 9. COUTO Marcus D. VIJAY MERCHANT – IN MEMORIAM. ACS&S of India 1988. Original wrappers. 122 pp. Good. £8.00 10. COUTO Marcus D. THE LEGENDS CLUB. Cricket Club of India [2003.] 27 pp. Booklet about the setting up of the club celebrating Vijay Marchant, Vijay Hazare and Vinoo Mankad. Original wrappers. New. £3.00 11. COWDREY Colin. M.C.C. THE AUTOBIOGRAPHY OF A CRICKETER. Coronet 1977. Original wrappers. Reading copy. £1.00 12. CREEK F.N.S. CRICKET. Teach Yourself Books 1975. Original Wrappers. Reading copy.
    [Show full text]
  • May 2019 Newsletter.Indd
    COMMUNITY DISABILITY may 2019 ICC Cricket World Cup Trophy Table Cricket Regional Finals came to Peterborough In the March Newsletter, we reported the Lord’s Taverners Table Cricket County Final winners - Denbigh High School, Luton Despite a yellow weather warning for severe winds, over 500 were the Bedfordshire winners and Spring Common Academy, people turned out to see the famous trophy at Peterborough Huntingdon won the Huntingdonshire Final. The Regional Finals Town Cricket Club on Saturday 27 April as part of the countdown will be taking place later this month - Denbigh High School will to cricket’s showpiece tournament! play in the London & Thames Valley Regional Final on 15 May Luton Wicketz Hubs go at Stoke Mandeville Stadium, Aylesbury and Spring Common After four months of planning, Cricket East, in partnership with School break sessions success Academy will play in the East Anglia Regional Final on 16 May Peterborough Town Cricket Club, laid on a fantastic Family Fun During the Easter half-term, the Wicketz project in Peterborough outdoors for summer! at Newmarket Leisure Centre. Day of Cricket for the community to come and watch, have a go ran FREE sessions for boys and girls aged 8-14 at Gladstone and spark excitement about this summer’s World Cup. Community Centre and Focus Community Centre. With almost The Luton Wicketz Hubs will be outdoors from week commencing We wish all players the very best of luck at their respective 100 children attending, the sessions offered a mixture of fi tness 6 May so come along and get involved – the Hubs are FREE for Regional Finals and fi ngers crossed they make it to the National The youth cricket activity kicked off as we welcomed children work, catching, bowling and batting drills and the sessions children and young adults aged 8-15.
    [Show full text]
  • Cricket Facts Legend Frindall Dies of Legionnaire's Disease - Yorkshire Post Page 1 of 2
    Cricket facts legend Frindall dies of Legionnaire's disease - Yorkshire Post Page 1 of 2 Site Web Search Wednesday, 15th July 2009 Cricket facts legend Frindall dies of Legionnaire's disease Bill Frindall « Previous « Previous Next » Next » ADVERTISEMENT Published Date: 31 January 2009 The cricketing world was mourning the loss of legendary statistician and broadcaster Bill Frindall last night after his death from Legionnaire's disease. It is believed he contracted the disease in Dubai, where he had been on a tour with the Lord's Taverners. He returned to the UK on January 20. Celebrities and former players including Rory Bremner and Mike Gatting were also on the tour. In a statement, the Lord's Taverners said: "All members of the touring party have been advised of the situation. We are not aware of any other member showing symptoms of Legionnaires' disease." Political satirist Bremner, who was a good friend of Frindall's, said: "Cricket has lost its living archive...Bill loved the game and his wry and mischievous humour belied his legendary meticulousness." The party stayed at the same hotel, the five-star Westin Dubai Mina Seyahi Beach Resort and Marina, for the trip. It is not known where Frindall contracted the disease, although the hotel has launched an investigation. It said three guests had contracted the bacteria but that tests had so far failed to find evidence of it on the premises. http://www.yorkshirepost.co.uk/news/Cricket-facts-legend-Frindall-dies.4933524.jp 7/15/2009 Cricket facts legend Frindall dies of Legionnaire's disease - Yorkshire Post Page 2 of 2 Frindall was the Test Match Special scorer from 1966 and was christened "the Bearded Wonder" by late commentator Brian Johnston for his encyclopaedic knowledge of cricket facts.
    [Show full text]