US 2006O1992.04A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/01992.04 A1 Dix et al. (43) Pub. Date: Sep. 7, 2006

(54) GENETIC TESTING FOR MALE FACTOR (60) Provisional application No. 60/327.525, filed on Oct. INFERTILITY 5, 2001. (75) Inventors: David Jacob Dix, Raleigh, NC (US); Publication Classification Stephen A. Krawetz, Detroit, MI (US); David Miller, Belmont Grove (GB) (51) Int. Cl. CI2O I/68 (2006.01) Correspondence Address: (52) U.S. Cl...... 435/6 BROWDY AND NEIMARK, P.L.L.C. 624 NINTH STREET, NW SUTE 3OO WASHINGTON, DC 20001-5303 (US) (57) ABSTRACT (73) Assignees: G EPA, Washington, DC (US); Wayne RNA in sperm can be used as a diagnostic to distinguish ate University, Detroit, MI (US); Uni- - versity of Leeds, Belmont Grove (GB) betweendiagnostic normal transcripts and affectedis provided individuals. which is A compared list of specific with (21) Appl. No.: 11/357,423 transcripts obtained from the sperm of a subject. Correlation between the two transcripts is used to identify normal sperm (22) Filed: Feb. 21, 2006 or affected sperm. Addition, genetic testing for male infer tility or damage to spermatozoa is accomplished by provid Related U.S. Application Data ing a microarray of DNA probes with a sample of sperma tozoa to determine the mRNA fingerprints of the sample, and (63) Continuation-in-part of application No. 10/264,321, comparing the mRNA fingerprints of the sample with the filed on Oct. 4, 2002, now abandoned. mRNA fingerprints of normal fertile male spermatozoa. Patent Application Publication Sep. 7, 2006 Sheet 1 of 11 US 2006/01992.04 A1

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Affected (8293Normal transcripts) (7227 transcripts)

Fig. 8. The partitioning of transcripts present in the normal individuals data set (left), both datasets (middle) and affected individuals data set (right) above the threshold value. Patent Application Publication Sep. 7, 2006 Sheet 9 of 11 US 2006/01992.04 A1

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'Fig. 9. Analysis of RNA transcripts present in sperm from thirteen normal and eight affected samples. The heat map shows that the levels of transcripts present in normal and affected individuals that can be distinguished. Six strikingly different regions from the Affymetrix analysis are shown that can be used to classify and diagnose individuals. Patent Application Publication Sep. 7, 2006 Sheet 10 of 11 US 2006/01992.04 A1

Fig. 10. Clustering of sperm RNA samples based on Illumina BeadChip array transcript data. Sperm transcripts from normal individuals are clearly distinguished from affected individuals. Patent Application Publication Sep. 7, 2006 Sheet 11 of 11 US 2006/0199204 A1

Fig.11. Clustering of the 661 transcripts consistently detected across all three array platforms, using data from Affymetrix arrays. Left panel, an example of Cluster 3.0 and TreeView consistently clustering normal individuals separate from affected individuals. Right panel, a segment of the corresponding 661 transcript heat map generated visually demonstrating the diagnostic capacity of the arrays. US 2006/01992.04 A1 Sep. 7, 2006

GENETIC TESTING FOR MALE FACTOR 0007 With the exception of obvious defects such as INFERTILITY aZoospermia, globoZoospermia, and immotile ciliary Syn drome, the extreme heterogeneity of normal fertile human CROSS-REFERENCE TO RELATED semen suggests that most idiopathic male factor infertility is APPLICATIONS not a result of monogenic disorders. Moreover, all known 0001. The present invention is a continuation-in-part of monogenic disorders that affect the testes affect other tissues application Ser. No. 10/264,321, filed Oct. 5, 2002, which to an equal or greater extent. Accordingly, it is reasonable to application claims priority from provisional application Ser. assume that the majority of idiopathic male factor infertility No. 60/327,525, filed Oct. 5, 2001, the entire contents of that has testes-restricted phenotypes is not monogenic, but both of which are hereby incorporated by reference. oligo- or poly-genic in origin. 0008 Two recent developments offer considerable prom FIELD OF THE INVENTION ise towards identifying oligo- and/or poly-genic factors that 0002 The present invention relates to methods, kits, and influence male fertility. First, the discovery of mRNAs in tools for distinguishing between sperm of normal and ejaculate spermatozoa makes it possible to obtain transcrip affected individuals. tional information from male germ cells using non-invasive procedures. It is expected that these mRNAs provide a BACKGROUND OF THE INVENTION window to past events of spermatogenesis, echoing tests for expression. Interestingly, data mining and functional 0003 Predicting the fertility of a male is very useful in a assessment suggests that in addition to delivering the hap variety of contexts. For example, the artificial insemination loid male genome, spermatozoa also deliver a critical industry is interested in knowing the likelihood that fertili complement of mRNAs to the . Secondly, microas zation will occur if a female is artificially inseminated with says make it possible to construct detailed a particular male's semen. Alternatively, human fertility profiles. clinics are concerned with achieving impregnation, and evaluating the sperm count of a male is one step in this 0009 Most laboratory investigations of semen quality are procedure. Thus, whether in the context of animal breeding, relatively poor indicators of fertility because they are sub the artificial insemination industry, or human fertility clinics, jective and predominantly rely on physiological and mor determination of the fertility of the male is very important. phological criteria. This is exemplified in the recent study that compared the predictive results from over 250 indepen 0004 Ten percent of the male population have abnor dent studies (Gynecol Obstet Invest. 2005:59(2) 86-91). mally low sperm counts, and approximately one in six Only 4 could be could be directly compared as the variation couples experiences difficulty in conceiving a child. Male among the others was too great. The consequences of using factor infertility accounts for 40-50% of the cases in which immature spermatids or other compromised germ cells in assisted reproductive techniques are recommended. The intra-cytoplasmic spermatozoa induction (CISI) procedures great majority (>98%) of infertile men actually produce need careful reappraisal, considering that spermatozoal sperm, but, for some reason, those sperm are often unable to mRNA is required for the production of normal offspring. fertilize an egg. Chromosomal anomalies are associated with approximately one third of non-obstructive male factor 0010 Thus, there is a need for an effective, efficient and infertility affecting some 2% of the infertile male population. accurate method and/or device for determining male fertil Half of these men (15%) present with abnormal karyotypes, ity. More specifically, there is a need for a method for which the other half (12-15%) present with microdeletions determining if a male is fertile using microarrays in analyZ in the Azoospermic Factor (AZF) region of Yq (i.e., DAZY/ ing mRNAS of spermatozoa. RBM). SUMMARY OF THE INVENTION 0005 Couples having difficulty starting a family must 0011. It is an object of the present invention to overcome undergo an extensive battery of tests, including a testicular the aforementioned difficulties of the prior art. biopsy. However, it has not yet been possible to identify which couples will never conceive, so that these couples can 0012. It is another object of the present invention to forgo the lengthy, expensive, and ultimately futile infertility provide a method for detecting if a male is a normal fertile therapy and begin considering other options, such as sperm male using microarrays in analyzing the mRNA of sperma donors. tOZOa. 0006 Testes-specific defects have only been demon 0013. It is a further object of the present invention to strated in men with sub-microscopic microdeletions of the Y provide a kit for detecting normal fertile males using encompassing one or more . It is reason microarrays in analyzing the mRNA of spermatozoa. able to expect that as new testes-specific genes are discov 0014. It is yet another object of the present invention to ered, more testes-restricted abnormalities will be revealed. provide markers for performing tests for detecting normal Lesions affecting the X and Y chromosome, as well as fertile males using microarrays in analyzing the mRNA of autosomal recessive and imprinted genes, have been asso spermatozoa. ciated with oligoZoospermia. These types of abnormalities, however, are rarely observed in clinics. The underlying 0015. It is another object of the present invention to causes of infertility in the remaining 98% of men with provide a test for determining if exposure to a toxin has non-obstructive defects in spermatogenesis remain adversely affected sperm. unknown. Accordingly, the majority of male factor infertili 0016. It is a further object of the present invention to ties are classified as idiopathic, indicating that other genetic distinguish between sperm of normal and affected individu factors should be considered. als. US 2006/01992.04 A1 Sep. 7, 2006

0017. It is another object of the present invention to 0026. Accordingly, profiling can be used to monitor past provide diagnostic transcripts for identifying and classifying events, such as gene expression of spermatogenesis. More sperm of normal and affected individuals. over, the data Suggest that, in addition to delivering-the paternal genome, spermatozoa provide the Zygote with a 0018 Microarray based platforms are used to show clear unique Suite of paternal mRNAS. Ejaculate spermatozoa can differences between the populations of RNA transcripts now be used as a non-invasive proxy for testes infertility present in the sperm of normal fertile individuals and investigations. affected individuals. The present invention includes a list of specific transcripts of diagnostic value. A differential heat 0027 Current research supports the diagnosis of idio map is used to identify differences between the transcripts pathic infertility via spermatozoal mRNA fingerprints, and present in normal and affected individuals. This provides a Suggests that spermatozoal transcripts complementing those present/absent measure that can be used as a unique classi of are important for embryo development. Male fier. gametes deliver more to the oocyte than the haploid male genome, and possess a greater role in orchestrating normal 0019. A core set of transcripts that are consistently embryo development than has heretofore been recognized. observed as present in normal fertile sperm has been vali dated across three microarray platforms. The relative levels 0028 Microarrays were developed containing tiny sites of this stable core set of transcripts can distinguish normal that trap specific mRNA. When sperm is added, color fertile sperm from affected sperm. The subset of specific and changes at each trap site indicate whether the sperm includes robust transcripts provided herein will yield a differential each bit of mRNA. Almost immediately, one can scan the heat map emphasizing the differences between normal and sperm to tell which mRNA, and which associated genes, are affected individuals. present. 0029. The present invention can be used in various set 0020. The present invention also provides a microarray tings, including, but not limited to, hospitals, fertility clinics, based diagnostic to detect normalcy of human spermatozoa. artificial insemination and animal breeding facilities, and This method provides an easy to interpret result of clinically any other similar settings that can use a test for determining diagnostic value from a diagnostic test that can be assayed fertility of a male. Although the present invention is illus in a routine clinical laboratory. trated in a human model, one skilled in the art can appreciate 0021. The present invention provides a test, kit, and that the invention is also applicable to and useful for animals method for determining male fertility. This invention pro other than humans. vides a genome-wide analysis to define the spermatozoal 0030. In one application of the present invention, fertile RNA fingerprint of a normal fertile male. The sperm spermatozoa are determined by determining the presence of microarray methods outlined herein provide mechanisms for mRNA. Thus, if mRNA is not present, then the spermatozoa identifying fertile and infertile males. are deemed to be non-functional. Additionally, the assay of 0022. The present invention uses microarray technology the present invention is useful intoxicological Screening and to monitor, in a sample of Spermatozoa, the presence of risk assessment to determine if a male species has suffered transcripts (messenger RNAs) from over 2700 genes that the permanent or temporary damage to spermatozoa popula inventors have determined to be critical to normal fertility. tions. A microarray chip is created by depositing onto slides 0031 Additionally, the assay of the present invention can microscopic quantities of the genetic material from these be used to identify specific mRNAs that are paternally genes, and then overlaying onto the slides the genetic derived and are critical to early human development. These material extracted from a sample ejaculate. If complemen parentally derived mRNAs include, but are not limited to, tary genetic material is present in the sample, it will bind to the following human uni-Gene: Hs.27695; Hs.19500; the genetic sites on the chip and be detected through laser Hs.8867; HS.46925; Hs.2714; Hs. 152213; Hs. 18195; excitation of bound fluorescence probes. Hs.2744.02: Hs.250899: Hs.2128; Hs.75106; Hs.86368: Hs.97633; and any other similar mRNA sequences known to 0023. In a similar manner, the invention can be used as a those of skill in the art. Since these paternally derived toxicological/epidemiological screen to determine the pres mRNAs are essential to development, they serve as excel ence of permanent or temporary damage to the spermatozoa lent markers. of males exposed to environmental toxicants, as well as the identity of paternally derived messenger RNAs that are BRIEF DESCRIPTION OF THE DRAWINGS critical to early human development. 0032 FIG. 1 is a fingerprint of human testes and sperm 0024. A suite of microarrays containing 27,016 expressed RNAS. sequence tags (ESTs) was interrogated using cDNAS from a pool of nineteen testes; cDNAs from a pool of nine indi 0033 FIG. 2 shows a distribution of testes and sperma vidual ejaculate spermatozoal mRNAs and cDNAs con tozoal RNAs. structed-from a single ejaculate’s spermatozoal mRNAS. 0034) FIG. 3 illustrates spermatozoal RNA ontogeny. 0.025 The testes, pooled and single ejaculate DNAS 0035 FIG. 4A-E show isolation of spermatozoal RNA. hybridized to 7157,3281, and 2784 ESTs, respectively. The testes population contained all of the ESTs identified by the 0.036 FIG. 4F illustrates fidelity of spermatozoal RNA cDNAs from the pooled and individual-ejaculate. The preparations. pooled ejaculate population contained all but 4 ESTs iden 0037 FIG. 5 shows genetic profiling of ejaculate sper tified from the individual ejaculate. matoZOa. US 2006/01992.04 A1 Sep. 7, 2006

0038 FIG. 6 is an example of chip-on-chip fold change material simultaneously. As is known, the-pattern of genes between normal individuals expressed in a cell is characteristic of its state. Additionally, virtually all differences in cell states correlate with changes 0.039 FIG. 7 is an example of chip-on-chip change in mRNA levels of genes. Generally, microarray technology between affected individuals. involves obtaining complementary genetic material to 0040 FIG. 8 shows the partitioning of transcripts present genetic material of interest and laying out the complemen in the normal individuals data set (left), both datasets tary genetic material in microscopic quantities on Solid (middle) and affected-individuals data set (right) above-the Surfaces at defined positions. Genetic material from Samples threshold value. is then eluted over the Surface, and complementary genetic 0041 FIG. 9 shows analysis of RNA transcripts present material binds thereto. The presence of bound genetic mate in sperm from thirteen normal and eight affected samples. rial is detected by fluorescence following laser excitation. The heat map shows that the levels of transcripts present in However, other detection means can also be used. normal and affected individuals that can be distinguished. 0047 As known to those skilled in the art, spermatoge Six strikingly different regions from the analyses are shown nesis is a multifaceted developmental program beginning that can be used to classify and diagnose individuals. with mitotic divisions of diploid spermatogonia. These divi sions give rise to spermatocytes, which undergo to 0.042 FIG. 10 shows clustering of sperm RNA samples produce haploid round spermatids. The final stage of sper based on Illumina Bead Chip array transcript data. Sperm matogenesis, termed spermiogenesis, is highlighted by the transcripts from normal individuals are clearly distinguished differentiation of round spermatides into spermatozoa. Once from affected individuals. spermatogenesis is complete, spermatozoa are released from 0.043 FIG. 11 shows clustering of the 661 transcripts their chaperones, the Sertli cells, through a process known as consistently detected across all three array platforms, using spermiation. Throughout the elaborate process of spermato data from Affymetrix arrays. FIG. 11A is an example of genesis, many testes-specific mRNAS are synthesized and cluster 3.0 ad TreeView consistently clustering normal indi placed under stringent translational control to ensure appro viduals separate from affected individuals. FIG. 11B shows priate temporal and spatial expression. The mRNAs a segment of the corresponding 661 transcript heat map observed in mature spermatozoa are remnants of untrans generated visually, demonstrating the diagnostic capacity of lated stores that provide a historic record or fingerprint of the arrays. spermatogenesis. Hence, the spermatazoal mRNA finger print representing the normal fertile male serves as a stan DETAILED DESCRIPTION OF THE dard for identifying the causes of idiopathic infertility. INVENTION Despite the obvious wealth of information contained within these repositories, the complexity and function of sperma 0044) The present invention provides a window into the tozoal mRNAs have not been characterized. Once defined, male reproductive system so that it is possible to monitor however, this fingerprint provides information on the under overall reproductive health with precision. The assays of the lying causes of male factor infertility and the reasons present invention can be used not only for predicting mRNAs remain in mature spermatozoa, while rRNAs are whether an individual is fertile or not, but also to obtain a most likely lost. detailed description of the gene-environment interaction for that individual. In the latter case, microarrays target genetic 0048 Several studies support the conclusion that sper differences between the normal male model and men who matozoa contain a complex repertoire of mRNAs. Even have been exposed to Suspected toxins. The microarray test though these mRNAs are thought to provide a window to provides a quick determination of whether a man’s sperm past events of spermatogenesis, their complexity and func had been adversely affected by a toxin. This approach takes tion have yet to be established. into account not only how most people respond and the 0049 RNA in sperm can be used to clearly distinguish exposure limits that have been set on how most people seem between normal and affected individuals. A database was to respond, but also how each individual responds. This constructed of sperm characteristics from semen analysis knowledge is particularly beneficial to men who are at high and donor lifestyle variables. Two sets of test samples risk of environmental toxin exposure through the workplace. characteristic of normal and affected individuals were In one example, a company could use the microarray test to selected and compared using the Affymetrix Human U133 monitor its male employees for overall exposure-induced plus 2 and Illumina Centrix Human Expression BeadChip changes in fertility. In another instance, an employee who platforms. The results obtained for both platforms for the was trying to start a family might request a test to ensure he normal fertile individuals were then compared to the results was fertile. In the latter case, if a problem did arise, the obtained in Ser. No. 10.264,231 based upon the Research employee could curtail his exposure and simply wait the Genetics spotted cDNA microarray platform, published in average 60-90 days for his body to replace the old sperm Ostermeier et al., Spermatozoal Lancet 360(8335): 772-7. with new, unexposed sperm. 2002. Sperm from reproductively normal individuals were 0045. In animal husbandry, particularly with beef pro analyzed on 16 Affymetrix Human U133 plus 2 chips and duction, cattle have a long gestation time. If one could two Illumina Centrix Human-6 Expression BeadChip arrays. ensure that every pregnancy outcome would be successful, A total of 16 normal samples were analyzed using the beef production-could be increased, thus increasing profit Affymetrix platform, of which 13 were of sufficient quality margins. to permit analysis. An additional two normal samples were then analyzed using the Illumina Centrix Human-6 Expres 0046) The use of microarray technology allows for the sion BeadChip platform. Both were of sufficient quality to study of complex interplay of genes and other genetic permit analysis. US 2006/01992.04 A1 Sep. 7, 2006

0050 Sperm samples from nine tetatozoospermia 2 platform were of sufficient quality to permit analysis. All affected individuals were analyzed using both the Affyme nine analyzed using the Illumina Centrix Human-6 expres trix Human U133 plus 2 chips and the Illumina Centrix sion BeadChip platform were of sufficient quality to permit Human-6 Expression BeadChips. Of the nine samples, eight analysis. that were analyzed using the Affymetrix Human U133 plus 0051 Data Obtained are Shown in Table 1

TABLE 1.

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID 1-acylglycerol-3-phosphate O-acyltransferase 5 AGPATS HS.490899 218096 at (lysophosphatidic acid acyltransferase, epsilon) 24-dehydrocholesterol reductase DHCR 24 HS.498.727 200862 at 2-aminoadipic 6-semialdehyde dehydrogenase AASDH HS104347 235435 at 3-hydroxyisobutyryl-Coenzyme A HIBCEH HS.236642 213374 x at 3-oxoacid CoA transferase 2 OXCT2 HS.472491 233301 at 3-phosphoinositide dependent protein kinase-1 PDPK1 HS.459691 32029 at 4-aminobutyrate aminotransferase ABAT HS.336768 20945.9 s at 5,10-methenyltetrahydrofolate synthetase (5- MTHFS HS.459049 210242 X at formyltetrahydrofolate cyclo-) 5,10-methylenetetrahydrofolate reductase MTHFR HS21.4142 239035 at (NADPH) 5-azacytidine induced 2 AZI2 HS.444724 218043 s at 5-azacytidine induced 2 AZI2 HS.444724 223846 at 5-hydroxytryptamine (serotonin) receptor 2A HTR2A HS.42498O 207135 at 5'-nucleotidase, cytosolic IB NTSC1B HS12O319 1554368 at 5'-nucleotidase, cytosolic IB NTSC1B HS12O319 243100 at 5'-nucleotidase, cytosolic I NTSC2 HS.158209 243158 at 5'-nucleotidase, cytosolic III NTSC3 HS.487933 223298 s at 5'-nucleotidase, cytosolic II-like 1 NTSC2L1 HSS2O341 223177 at 5'-nucleotidase, cytosolic II-like 1 NTSC2L1 HS.S2O341 223178 s at 6-pyruvoyl-tetrahydropterin synthase/dimerization DCOHM HSS27213 224372 at of hepatocyte nuclear factor 1 alpha (TCF1) 2 i? 6-pyruvoyl-tetrahydropterin synthase dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 6-pyruvoyl-tetrahydropterin synthase/dimerization DCOHM HS.S27213 224373 s at cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 i? 6-pyruvoyl-tetrahydropterin synthase dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 82-kD FMRP Interacting Protein 182-FIP HS.462598 224938 a 82-kD FMRP Interacting Protein 182-FIP HS.462598 224939 a a disintegrin and metalloproteinase domain 17 ADAM17 HS.404914 205745 X at (tumor necrosis factor, alpha, converting ) isintegrin and metalloproteinase domain 18 ADAM18 HS-127930 207597 a isintegrin and metalloproteinase domain 20 ADAM2O HS.177984 207423 s at isintegrin and metalloproteinase domain 21 ADAM21 HS.178748 1552579 a. at isintegrin and metalloproteinase domain 21 ADAM21 HS.178748 2O7665 a isintegrin and metalloproteinase domain 28 ADAM28 HSS283O4 208268 a isintegrin and metalloproteinase domain 29 ADAM29 HS126838 221337 s at isintegrin and metalloproteinase domain 3a ADAM3A HS.98848 21627.6 s at (cyritestin 1) a disintegrin and metalloproteinase domain 6 ADAM6 HS.97508 237909 a A disintegrin-like and metalloprotease (reprolysin ADAMTSS HSS8324 235368 a type) with thrombospondin type 1 motif, 5 (aggrecanase-2) a disintegrin-like and metalloprotease (reprolysin ADAMTS9 HS.549184 220287 a type) with thrombospondin type 1 motif, 9 kinase (PRKA) anchor protein 1 AKAP1 HS.4635O6 201674 S at kinase (PRKA) anchor protein 1 AKAP1 HS.4635O6 201675 a kinase (PRKA) anchor protein 1 AKAP1 HS.4635O6 240495 a kinase (PRKA) anchor protein 10 AKAP10 HS.462457 23.6007 a kinase (PRKA) anchor protein 11 AKAP11 HS105105 203156 a kinase (PRKA) anchor protein 11 AKAP11 HS105105 215336 a kinase (PRKA) anchor protein 13 AKAP13 HS.459211 209534 X at kinase (PRKA) anchor protein 13 AKAP13 HS.459211 222024 S at kinase (PRKA) anchor protein 13 AKAP13 HS.459211 243450 a kinase (PRKA) anchor protein 14 AKAP14 HS.184993 237281 a kinase (PRKA) anchor protein 2 / PALM2 AKAP2 HS259461 202760 S at AKAP2 protein PALM2 AKAP2 US 2006/01992.04 A1 Sep. 7, 2006

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID A kinase (PRKA) anchor protein 4 AKAP4 S.97633 207019 s at A kinase (PRKA) anchor protein 6 AKAP6 S.SO9083 205359 at Abelson helper integration site AHI1 S.386684 221569 at abhydrolase domain containing 1 ABHD1 S.375791 236461 at abhydrolase domain containing 2 ABHD2 S.122337 205566 at abl-interactor 1 ABI1 S.508148 209027 s at Abl-interactor 1 ABI1 S.508148 238,563 at absent in melanoma 1 AIM1 S.486074 212543 at absent in melanoma 2 AIM2 S.281898 206513 at acetyl-Coenzyme A acetyltransferase 1 ACAT1 S.232.375 205412 at (acetoacetyl Coenzyme A thiolase) acetyl-Coenzyme A acetyltransferase 2 ACAT2 S.363 137 209608 s a (acetoacetyl Coenzyme A thiolase) acheron FLJ11196 S.416755 236565 s a acid phosphatase 1, Soluble ACP1 S.130873 215227 x a Acidic (leucine-rich) nuclear phosphoprotein 32 ANP32A S.458747 201051 at family, member A acidic (leucine-rich) nuclear phosphoprotein 32 ANP32B S.494-604 2013.05 x a family, member B Acidic (leucine-rich) nuclear phosphoprotein 32 ANP32E 229128 s a family, member E acrosin binding protein ACRBP S.123239 223717 s a acrosomal vesicle protein 1 ACRV1 S.169222 207969 x a acrosomal vesicle protein 1 ACRV1 S.169222 207973 X a acrosomal vesicle protein 1 ACRV1 S.169222 208013 s a actin related protein 2/3 complex, subunit 2, 34 kDa ARPC2 S.S29303 207988 s a actin related protein 2/3 complex, subunit 2, 34 kDa ARPC2 S.S29303 208.679 S a actin related protein 2/3 complex, subunit 2, 34 kDa ARPC2 S.S29303 213513 X a actin related protein 2/3 complex, subunit 5-like ARPCSL S.132499 223101 s a Actin related protein 2/3 complex, Subunit 5-like ARPCSL S.132499 236780 at actin, beta ACTB S.S2O640 200801 x a actin, beta ACTB S.S2O640 3867 x a actin, beta ACTB S.S2O640 24594 x a actin, gamma 1 ACTG1 S.514581 1550 x a actin, gamma 1 ACTG1 S.514581 1970 x a actin, gamma 1 ACTG1 S.514581 1983 x a actin, gamma 1 ACTG1 S.514581 1995 X a actin, gamma 1 ACTG1 S.514581 2363 x a actin, gamma 1 ACTG1 S.514581 2988 x a actin, gamma 1 ACTG1 S.514581 3214 X a actin, gamma 1 ACTG1 S.514581 1607 X a actin, gamma 1 ACTG1 S.514581 24585 x a Activated leukocyte cell adhesion molecule ALCAM S.150693 40655 at activated RNA polymerase II transcription cofactor 4 PC4 S.229641 212857 X a activating signal cointegrator 1 complex subunit 1 ASCC1 S.SOOOO7 1554627 a. at Activating signal cointegrator 1 complex subunit 3 ASCC3L1 S.246112 232931 at like 1 activating signal cointegrator 1 complex subunit 3 ASCC3L1 S.246112 200058 s a like 1 if activating signal cointegrator 1 complex subunit 3-like 1 activating transcription factor 2 ATF2 S.425.104 205446 s a activating transcription factor 3 ATF3 S.460 202672 s a activating transcription factor 4 (tax-responsive ATF4 S.496487 200779 at enhancer element B67) activating transcription factor 5 ATF5 S.9754 204998 s a activating transcription factor 7 interacting protein ATF7IP S.5464O6 21.8987 at activating transcription factor 7 interacting protein ATF7IP S.5464O6 231825 x a Activating transcription factor 7 interacting protein 2 ATF7IP2 S.513343 228381 at activin A receptor, type IB ACVR1B S.438918 213198 at activity-dependent neuroprotector ADNP S.293736 201773 at Activity-dependent neuroprotector ADNP S.293736 222366 at Activity-dependent neuroprotector ADNP S.293736 226426 at acyl-CoA synthetase long-chain family member 3 ACSL3 S.471461 201661 s at acyl-CoA synthetase long-chain family member 6 ACSL6 S.14945 211207 s at Acyl-CoA synthetase long-chain family member 6 ACSL6 S.14945 216409 at acyl-Coenzyme A dehydrogenase family, member 9 ACAD9 S.541841 224160 s at acyl-malonyl condensing enzyme 1 AMAC1 S.514814 1553471 at acyl-malonyl condensing enzyme 1-like 2 if acyl AMAC1L2 S.514814 1553340 s at malonyl condensing enzyme 1 AMAC1 acylphosphatase 2, muscle type ACYP2 S.S16173 206833 s at US 2006/01992.04 A1 Sep. 7, 2006

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID DAM-like, decysin 1 DAMDEC1 S.521459 206134 at DAMTS-like 3 DAMTSL3 S.45916.2 213974 at daptin-ear-binding coat-associated protein 1 ECAP1 S.S27839 1559495 at aptin-ear-binding coat-associated protein 2 ECAP2 S.437385 2301.23 at daptor-related protein complex 1, sigma 2 subunit P1S2 S.121592 228415 at aptor-related protein complex 3, sigma 1 subunit P3S1 S.406,191 202442 at aptor-related protein complex 3, sigma 2 subunit P3S2 S.546,334 202399 s at aptor-related protein complex 4, beta 1 subunit P4B1 S.51504.8 231714 S at ditional sex combs like 1 (Drosophila) SXL1 S.374O43 212237 at ditional sex combs like 1 (Drosophila) SXL1 S.374O43 212238 at ditional sex combs like 2 (Drosophila) SXL2 S.119815 218659 at ducin 1 (alpha) i? adducin 1 (alpha) DD1 S.183706 208030 S at ducin 2 (beta) DD2 S.188528 206807 s at ducin 3 (gamma) DD3 S.5O1012 201752 s at ducin 3 (gamma) DD3 S.5O1012 201753 S at enosylmethionine decarboxylase 1 MD1 S.1591.18 201196 s at enosylmethionine decarboxylase 1 MD1 S.1591.18 201197 at enylate cyclase 2 (brain) DCY2 S.481545 217687 at enylate cyclase 3 DCY3 S.467898 209320 at denylate kinase 3 K3 S.10862 225342 at enyloSuccinate synthase DSS S.4983.13 221761 at P-ribosylation factor 1 F1 S.286221 208750 s at -ribosylation factor 4 S.14833O 201097 s at -ribosylation factor 4-like S.183153 203586 s at -ribosylation factor 6 S.S2S330 203312 x at -ribosylation factor 6 S.S2S330 214182 at -ribosylation factor 6 F6 S.S2S330 224788 at -ribosylation factor GTPase activating protein 1 FGAP1 S.25584 217888s at -ribosylation factor guanine nucleotide FGEF1 S.411848 216266 s at hange factor 1 (brefeldin A-inhibited) 5 P-ribosylation factor guanine nucleotide RFGEF1 S.411848 236742 at hange factor 1 (brefeldin A-inhibited) 5 P-ribosylation factor guanine nucleotide RFGEF2 S.62578 222518 at hange factor 2 (brefeldin A-inhibited) P-ribosylation factor-like L O C5 1 3 2 6 S.S491.59 210718 S at -ribosylation factor-like 10C S.2SOOO9 217852 s at -ribosylation factor-like 2 binding protein S.S13631 202092 s at -ribosylation factor-like 3 S.182215 202641 a - ibosylation factor-like 4A S.245540 205020 S at -ribosylation factor-like 5 S.47O233 218150 a -ribosylation factor-like 6 interacting protein S.75249 211935 a. -ribosylation factor-like 8 S.25362 226345 a. -ribosylation-like factor 6 interacting protein 5 S.518060 200761 s at P-ribosylhydrolase like 2 S.18021 223097 a renergic, beta, receptor kinase 2 S.S.17493 204183 s at renomedullin S.441047 202912 a renomedullin receptor S.483909 1552440 at renomedullin receptor DMR S.483909 214506 a ult retina protein OC153222 S.484.195 1554229 at ult retina protein OC153222 S.484.195 225956 a iphilin protein FTIPHILIN S.468760 217939 S at iphilin protein FTIPHILIN S.468760 222472 a AG1 protein EO1 S.44508O 237,917 a alanyl-tRNA synthetase AA RS S.315137 201000 a alcohol dehydrogenase 4 (class II), pi polypeptide H4 S.1219 223781 X at alcohol dehydrogenase 5 (class III), chi H5 S.78989 208847 s at polypeptide Aldehyde dehydrogenase 6 family, member A1 S.293970 221589 s at aldehyde dehydrogenase 7 family, member A1 S.483.239 208950 S at Aldehyde dehydrogenase 7 family, member A1 S.483.239 208951 at aldo-keto reductase family 1, member C1 S.46O260 204151 X at (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)- hydroxysteroid dehydrogenase) aldo-keto reductase family 7, member A2 (aflatoxin S.S12807 214259 s at aldehyde reductase) Aldolase A, fructose-bisphosphate pseudogene 2 S.148259 1556133 s at ALL1 fused gene from 5q31 S.S1931.3 219199 at ALL1 fused gene from 5q31 S.S1931.3 232865 at ALL1-fused gene from chromosome 1 q if ALL1 S.75823 211071 s at fused gene from chromosome 1 q all-trans-13, 14-dihydroretinol saturase RetSat S.440401 218124 at US 2006/01992.04 A1 Sep. 7, 2006

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID alpha thalassemiamental retardation syndrome X ATRX S.S33526 2088.61 s at linked (RAD54 homolog, S. cerevisiae) alpha-1,3(6)-mannosylglycoprotein beta-1,6-N- LOC90693 S.232296 228061 at acetyl-glucosaminyltransferase-like alpha-2-macroglobulin A2M S.212838 15584.50 at alpha-kinase 2 ALPK2 S.388.674 228367 at alpha-methylacyl-CoA racemase AMACR S.SO8343 209426 s at Alport syndrome, mental retardation, midface AMMECR1 S.211021 204976 s at hypoplasia and elliptocytosis chromosomal region, gene 1 Alstrom Syndrome 1 ALMS1 S.18472O 214220 S at Alstrom Syndrome 1 ALMS1 S.18472O 214707 x at Alstrom Syndrome 1 ALMS1 S.18472O 233788 at amelogenin (amelogenesis imperfecta 1, X-linked) AMELX S.46329 208410 x at amiloride binding protein 1 (amine oxidase ABP1 S.S21296 203559 s at (copper-containing)) amine oxidase, copper containing 2 (retina AOC2 S.1431 O2 207064 S at specific) amino acid transporter FLJ10815 S.10499 218727 at Amino acid transporter FLJ10815 S.10499 228951 at amino acid transporter FLJ10815 S.10499 56821 at aminoacylase 1-like 2 ACY1L2 S.356247 225431 x at aminoadipate-semialdehyde dehydrogenase AASDHPPT S.524OO9 202169 s at phosphopantetheinyl transferase aminoadipate-semialdehyde dehydrogenase AASDHPPT S.524OO9 202170 s at phosphopantetheinyl transferase ( AMT S.102 204294 at protein T) amplified in osteosarcoma OS-9 S.S27861 200714 x at amylase, alpha 1A: Salivary if f amylase, alpha 1B: AMY1A S.514463 208498 s at salivary amylase, alpha 1C: salivary amylase, alpha 2A; pancreatic amylase, alpha 2B: AMY1B pancreatic AMY1C

AMY2A

AMY2B amylo-1,6-glucosidase, 4-alpha AGL S.904 203566 s at glucanotransferase (glycogen debranching enzyme, glycogen storage disease type III) amyloid beta (A4) precursor protein-binding, family PBB2 S.4796O2 40148 at B, member 2 (Fe(65-like) amyloid beta (A4) precursor protein-binding, family PBB3 S.529449 204650 s at B, member 3 amyloid beta (A4) precursor-like protein 2 PLP2 S.370247 208.248 x at amyloid beta precursor protein (cytoplasmic tail) PPBP2 S.84084 202631 s at binding protein 2 amyotrophic lateral sclerosis 2 (juvenile) S.335788 1553260 s at chromosome region, candidate 11 amyotrophic lateral sclerosis 2 (juvenile) S.335788 1554831 x at chromosome region, candidate 11 amyotrophic lateral sclerosis 2 (juvenile) S.471130 1553220 at chromosome region, candidate 13 amyotrophic lateral sclerosis 2 (juvenile) S.54648O 1554106 at chromosome region, candidate 16 Amyotrophic lateral sclerosis 2 (juvenile) S.152774 235983 at chromosome region, candidate 3 amyotrophic lateral sclerosis 2 (juvenile) S.12319 1553956 at chromosome region, candidate 4 AN1, ubiquitin-like, homolog (Xenopus laevis) ANUBL1 S.89029 242650 at AN1, ubiquitin-like, homolog (Xenopus laevis) ANUBL1 S.89029 244206 at Anaphase promoting complex subunit 1 ANAPC1 S.436527 229267 at anaphase promoting complex subunit 1 ANAPC1 S.436527 231973 s at anaphase promoting complex subunit 13 ANAPC13 S.106909 209001 s at anaphase promoting complex subunit 5 ANAPCS S.71O1 208721 S at anaplastic lymphoma kinase (Ki-1) ALK S.196534 208.212 s at Angiomotin like 1 AMOTL1 S.SO3594 240877 x at angiotensin II receptor, type 1 AGTR1 S.477887 205357 s at anillin, actin binding protein (scraps homolog, ANLN S.6218O 1552619 a. at Drosophila) US 2006/01992.04 A1 Sep. 7, 2006

TABLE 1-continued

Gene Title and Probe Set ID

tle Gene Title Symbol UniGene ID Probe Set ID Ankyrin 1, erythrocytic ANK1 HS.491558 240363 at and KH domain containing 1 ANKHD1 HS.4342.19 219081 at ankyrin repeat and KH domain containing 1 if ANKHD1 HS.4342.19 208773 s at MASK-4E-BP3 alternate reading frame gene MASK BP3 ankyrin repeat and MYND domain containing 2 ANKMY2 HS.157378 212798 s at ankyrin repeat and SOCS box-containing 12 ASB12 HS.S6281 236033 at ankyrin repeat and SOCS box-containing 17 ASB17 HS.125423 231622 at Ankyrin repeat domain 12 ANKRD12 HS.464585 23.9450 at ankyrin repeat domain 15 ANKRD15 HS.493272 213005 s at ankyrin repeat domain 15 ANKRD15 HS.493272 238789 at ankyrin repeat domain 20A chromosome 21 ANKRD2OA HS.S221.78 1569607 S. at open reading frame 81 similar to ankyrin repeat domain 20A OTTHUMPOOOOOO15360 OTTHUMPOOOOOO6458O LOC440841

LOC441425

LOC441430 ankyrin repeat domain 28 ANKRD28 S.33S239 2293.07 a ankyrin repeat domain 29 ANKRD29 S.374774 238332 a ankyrin repeat domain 5 ANKRDS S.70903 222951 s at ankyrin repeat domain 7 ANKRD7 S.371820 206112 a ankyrin repeat domain 9 ANKRD9 S.432945 230972 a. annexin A1 ANXA1 S.494.173 201012 a annexin A2 ANXA2 S.S116OS 1568126 at annexin A2 ANXA2 S.S116OS 201590 x at annexin A2 ANXA2 S.S116OS 210427 X at annexin A5 ANXAS S.480653 200782 a anterior pharynx defective 1 homolog A (C. elegans) A. S.1084.08 218389 s at anterior pharynx defective 1 homolog B (C. elegans) A. S.S11703 221036 s at // anterior pharynx defective 1 homolog B (C. elegans) Anthrax toxin receptor 1 ANTXR1 S.165859 232808 a antizyme inhibitor 1 AZIN1 S.4591 O6 201772 a. AP1 gamma Subunit binding protein 1 AP1GBP1 S.101480 222715 S at AP1 gamma Subunit binding protein 1 AP1GBP1 S.101480 239678 a AP2 associated kinase 1 AAK1 S.SS2584 205434 S at APG12 autophagy 12-like (S. cerevisiae) S.264482 213026 a APG3 autophagy 3-like (S. cerevisiae) S.477126 221492 s at APG4 autophagy 4 homolog A (S. cerevisiae) HS.8763 213115 a. APG5 autophagy 5-like (S. cerevisiae) S.486063 210639 s at APG7 autophagy 7-like (S. cerevisiae) S.38032 1569827 at apobec-1 complementation factor CF S.499643 220951 s at apolipoprotein B mRNA editing enzyme, catalytic POBE S.441124 209584 X at polypeptide-like 3C Apollipoprotein E POE S.S1546S 212884 x at apolipoprotein M POM S.534468 205682 x at apoptosis inhibitor 5 PI5 S.435771 201686 X at apoptosis-related protein PNAS-1 FLJ39616 S.33312O 1553987 at aprataxin S.2O158 218527 a aquaporin 3 S.234.642 39248 at aquarius homolog (mouse) QR SS10958 212584 a Arachidonate 12-lipoxygenase LOX12 S.422967 229833 a vasopressin-induced 1 S.23918 2186.31 a Arginine-glutamic acid dipeptide (RE) repeats S.463O41 232877 a Arginine-glutamic acid dipeptide (RE) repeats s S.463O41 244.625 a. arginyl-tRNA synthetase-like S.48591O 225264 a ariadne homolog, ubiquitin-conjugating enzyme E2 A. RI H1 S.268787 201881 s at binding protein, 1 (Drosophila) Ariadne homolog, ubiquitin-conjugating enzyme E2 S.268787 242431 a binding protein, 1 (Drosophila) armadillo repeat containing 1 S.269.542 222550 a armadillo repeat containing 2 S.282925 223866 a armadillo repeat containing 8 S.266826 2034.86 s at armadillo repeat containing, X-linked 1 HS.9728 218694 a armadillo repeat containing, X-linked 6 S.83S30 214749 s at ARP2 actin-related protein 2 homolog (yeast) S.3932O1 1554390 s. at US 2006/01992.04 A1 Sep. 7, 2006

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID ARP2 actin-related protein 2 homolog (yeast) ACTR2 S.3932O1 1558015 S. at ARP2 actin-related protein 2 homolog (yeast) ACTR2 S.3932O1 2007 27 S at ARP2 actin-related protein 2 homolog (yeast) ACTR2 S.3932O1 200729 s at ARP3 actin-related protein 3 homolog (yeast) ACTR3 S.433512 200996 at ARP3 actin-related protein 3 homolog (yeast) ACTR3 S.433512 213101 s at ARP3 actin-related protein 3 homolog (yeast) ACTR3 S.433512 213102 at ARP3 actin-related protein 3 homolog (yeast) ACTR3 S.433512 228.603 at ARP6 actin-related protein 6 homolog (yeast) ACTR6 S.115088 239679 at ARP8 actin-related protein 8 homolog (yeast) ACTR8 S.412186 222707 s at arrestin domain containing 4 ARRDC4 HS.6093 225283 at Arrestin, beta 2 S.435811 1559436 X at arsenate resistance protein ARS2 S.111801 222047 s at Aryl hydrocarbon receptor nuclear translocator S.131494 231016 s at ASF1 anti-Silencing function 1 homolog A (S. cerevisiae) S.292316 203428 s at Ashl (absent, Small, or homeotic)-like (Drosophila) S.491O60 1554057 at h1 (absent, Small, or homeotic)-like (Drosophila) ASH1L. S.491O60 222667 s at paraginase like 1 ASRGL1 S.S35326 218857 s at paragine-linked glycosylation 5 homolog (yeast, ALGS S.SOf 769 218203 a dolichyl-phosphate beta-glucosyltransferase) paragine-linked glycosylation 8 homolog (yeast, ALG8 S.SO3368 203545 a. alpha-1,3-glucosyltransferase) partyl aminopeptidase DNPEP S.258551 215135 a. partyl aminopeptidase DNPEP S.258551 38703 at partylglucosaminidase AGA S.2O7776 204332 S at Erotactin 2 ASTN2 S.2O9217 215407 s at rich interactive domain 1B (SWI1-like) ARID1B S.291587 238.043 a rich interactive domain 4B (RBP1-like) fif AT ARID4B S.S33633 221230 s at rich interactive domain 4B (RBP1-like) Trich interactive domain 5B (MRF1-like) ARIDSB S.S467SS 1563469 at Trich interactive domain 5B (MAF1-like) ARIDSB S.S467SS 241837 a axin 1 ATXN1 S.434961 1559249 at ATXN10 S.47512S 208832 a ATXN10 S.47512S 208833 s at ATXN2 S.76253 2371.84 a ATXN2 S.76253 23.8589 S at ataxin 7 ATXN7 S476,595 204516 a onal homolog 8 (Drosophila) ATOH8 S.135569 15587O6 a. at A TP citrate ACLY S.387567 201127 s at A Psynthase, H+ transporting, mitochondrial FO ATP5F1 S.S.14870 211755 S at CO mplex, subunit b, isoform 1 if ATP synthase, H+ transporting, mitochondrial FO complex, Subunit b, isoform A TP synthase, H+ transporting, mitochondrial FO ATPSI S.85539 207335 x at CO mplex, Subunite A TP synthase, H+ transporting, mitochondrial FO ATPSI S.85539 209492 x at CO mplex, Subunite A TP synthase, H+ transporting, mitochondrial FO ATP5 S.246,310 202325 s at CO mplex, subunit F6 A TP synthase, H+ transporting, mitochondrial FO ATP5S S.438489 206993 at CO mplex, subunits (factor B) A TP synthase, H+ transporting, mitochondrial FO ATP5S S.438489 213995 at CO mplex, subunits (factor B) A TP synthase, H+ transporting, mitochondrial F1 ATPSA1 S.298.28O 213738 s a CO mplex, alpha Subunit, isoform 1, cardiac muscle A TP synthase, H+ transporting, mitochondrial F1 ATP5D S.418668 203926 x a CO mplex, delta Subunit A TP synthase, H+ transporting, mitochondrial F1 ATP5E S.546238 217801 at CO mplex, epsilon Subunit A TP synthase, H+ transporting, mitochondrial F1 S.27113S 208870 x a CO mplex, gamma polypeptide 1 A CP/GTP binding protein 1 AGTPBP1 S.494,321 204500 s a A CP/GTP binding protein 1 AGTPBP1 S.494,321 242008 at A TP/GTP-binding protein HEAB S.S23687 204370 at A TPase family, AAA domain containing 2 ATAD2 S.370834 21878.2 s a A Pase inhibitory factor 1 ATPIF1 S.241336 218671 s a A Pase inhibitory factor 1 ATPIF1 S.241336 223338 s a A Pase type 13 A5 ATP13AS 1553567 s at A Pase, Ca++ transporting, cardiac muscle, slow ATP2A2 S.S.06759 20918.6 at twitch 2 A Pase, Ca++ transporting, type 2C, member 1 ATP2C1 S.546.361 212255 s a A Pase, Ca++ transporting, type 2C, member 1 ATP2C1 S.546.361 230387 at US 2006/01992.04 A1 Sep. 7, 2006 10

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID ATPase, Class I, type 8B, member 1 S.216623 214594 x at ATPase, Class II, type 9B S.465475 243615 at ATPase, Class VI, type 11B S.478429 1564064 a at ATPase, Class VI, type 11B S.478429 212536 at ATPase, Class VI, type 11B S.478429 238811 at ATPase, H+ transporting, ysosomal 13 kDa, V S.388654 208737 at subunit G isoform 1 ATPase, H+ transporting, ysosomal 13 kDa, V S.388654 238765 at subunit G isoform 1 ATPase, H+ transporting, ysosomal 31 kDa, V S.S34515 1552286 at subunit E isoform 2 ATPase, H+ transporting, ysosomal 34 kDa, V S.272630 208899 X at subunit D ATPase, H+ transporting, ysosomal 34 kDa, V S.272630 214923 at subunit D ATPase, H+ transporting, ysosomal 38 kDa, VO S.106876 239633 at subunit d isoform 1 ATPase, H+ transporting, ysosomal 42 kDa, V S.86905 202874 S at Subunit C, isoform, 1 ATPase, H+ transporting, ysosoma 50/57 kDa, V1 S.491737 1557586 s at subunit H ATPase, H+ transporting, ysosomal 70 kDa, V S.4771 SS 201971 s at Subunit A ATPase, H+ transporting, ysosomal 70 kDa, V S.4771 SS 201972 at Subunit A ATPase, H+ transporting, ysosomal 9 k Da, VO S.484.188 201172 X at subunite ATPase, H+ transporting, ysosomal 9 k Da, VO S.484.188 200096 s. at Subunit e if ATPase, H+ transporting, lysosomal 9 kDa, VO subunite ATPase, H+ transporting, ysosomal VO Subunit a S.463074 212383 at isoform ATPase, Na+/K+ transporting, beta 1 po ypeptide S.291196 201242 S at ATPase, Na+/K+ transporting, beta 3 po ypeptide S.477789 208836 at ATPase, Na+/K+ transporting, beta 3 po ypeptide A S.477789 2297.09 at ATP-binding cassette, Sub ami y A (ABC1), S.429294 203504 S at lele ATP-binding cassette, Sub 8.ily A (ABC1), BCA1 S.429294 203505 at lele ATP-binding cassette, Sub 8.ily C (CFTR/MRP), BCC1 S.391464 202804 at lele ATP-binding cassette, Sub 8.ily C (CFTR/MRP), BCC5 S.368563 209380 S at member 5 ATP-binding cassette, Sub 8.ily C (CFTR/MRP), BCC9 S.446OSO 1557374 at member 9 ATP-binding cassette, Sub 8.ily D (ALD), BCD3 S.76781 202850 at member 3 ATP-binding cassette, Sub 8.ily E (OABP), BCE1 S.12013 201872 S at lele ATP-binding cassette, Sub 8.ily G (WHITE), BCG1 S.124649 204567 S at lele ATP-binding cassette, Sub 8.ily G (WHITE), S.4802.18 209735 a. member 2 ATP-binding cassette, Sub 8.ily G (WHITE), S.126378 207593 a member 4 Atrophin 1 RPLA S.143766 236961 a A. U RNA binding protein enoyl-Coenzyme A UH S.17590S 205052 a hydratase aurora-A kinase interacting protein S.472S35 225.552 x at autism susceptibility candidate 2 S.21631 212599 a AXIN1 up-regulated 1 AXUD1 S.3709SO 225557 a AYP1 protein AYP1 S.397010 226453 a bA255A11.10 (putative novel T cell receptor beta bA255A11.1 S.521441 234686 a chain V region protein) baculoviral IAP repeat-containing 6 (apollon) BIRC6 S.15O107 224635 S at baculoviral IAP repeat-containing 6 (apollon) BIRC6 S.15O107 233093 S at Baculoviral IAP repeat-containing 6 (apollon) BIRC6 S.15O107 242068 a BAI1-associated protein 1 BAIAP1 S.169441 1559256 at BAI1-associated protein 1 BAIAP1 S.169441 1559257 a. at BAI1-associated protein 1 BAIAP1 S.169441 206144 a BAI1-associated protein 2-like 1 BAIAP2L1 S.489237 227372 S at US 2006/01992.04 A1 Sep. 7, 2006 11

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Bardet-Biedl syndrome 2 BBS2 S.333738 223227 at Bardet-Biedl syndrome 4 BBS4 S.2O8681 212744 at Bardet-Biedl syndrome 7 BBS7 S.S8974 235.007 at basic leucine Zipper and W2 domains 1 BZW1 S355983 200777 s at basic leucine Zipper and W2 domains 2 BZW2 S.48763S 217809 at basic transcription factor 3 BTF3 S.S29798 211939 x at basic transcription factor 3 similar to BTF3 S.S29798 214800 x at Transcription factor BTF3 (RNA polymerase B LOC345829 transcription factor 3) BAT2 domain containing 1 BAT2D1 S.494.614 211946 s at BAT2 domain containing 1 BAT2D1 S.494.614 211948 x at BAT2 domain containing 1 BAT2D1 S.494.614 214055 x at B-box and SPRY domain containing BSPRY S.494870 22274.6 s at BBP-like protein 2 // BBP-like protein 2 BLP2 S.288912 221702 s at B-cell CLL/lymphoma 10 BCL10 S.549082 1557257 at B-cell CLL/lymphoma 10 BCL10 S.549082 1557258 a. at B-cell CLL/lymphoma 9 BCL9 S.415209 222350 at B-cell receptor-associated protein 29 BCAP29 S.3O3787 225674 at B-cell receptor-associated protein 29 BCAP29 S.3O3787 241646 s a B-cell translocation gene 1, anti-proliferative BTG1 S.255935 200920 S a B-cell translocation gene 1, anti-proliferative BTG1 S.255935 200921 s a BCL2/adenovirus E1B 19 kDa interacting protein 3 BNIP3 S.144873 201849 at BCL2/adenovirus E1B 19 kDa interacting protein 3 BNIP3L S.131226 221479 s a ike // BCL2/adenovirus E1B 19 kDa interacting protein 3-like BCL2-associated athanogene BAG1 S.377484 211475 s a BCL2-associated athanogene BCL2-associated BAG1 S.377484 202387 at athanogene BCL2-associated athanogene 3 BAG3 S.S23.309 217911 s 8. BCL2-associated athanogene 5 BAGS S.5443 202984 S 8. BCL2-associated athanogene 5 BAGS S.5443 202985 S a BCL2-associated transcription factor 1 BCLAF1 S.486542 201083 s a BCL2-associated transcription factor 1 BCLAF1 S.486542 201084 S a BCL2-associated transcription factor 1 BCLAF1 S.486542 214499 s a BCL2-like 11 (apoptosis facilitator) BCL2L11 S.469658 1553O88 a. at BCL2-like 11 (apoptosis facilitator) BCL2L11 S.469658 1553.096 S. at BCL2-like 11 (apoptosis facilitator) BCL2L11 S.469658 1555372 at BCL2-like 11 (apoptosis facilitator) BCL2L11 S.469658 222343 at BCL2-like 14 (apoptosis facilitator) if BCL2-like 14 BCL2L14 S.5491.94 221241 s a (apoptosis facilitator) beclin 1 (coiled-coil, myosin-like BCL2 interacting BECN1 S.12272 208945 s a protein) beta-2-microglobulin 2 M S.S342SS 201891 s a beta-amyloid binding protein precursor BP S.276876 213883 s a beta-site APP-cleaving enzyme 2 ACE2 S.5294.08 217867 x a beta-transducin repeat containing TRC S.500812 216091 s a bicaudal Chomolog 1 (Drosophila) CC1 S.158745 220580 at biglycan S.821 201261 x a Bladder cancer associated protein LCAP S.472651 1557521 a. at bladder cancer associated protein LCAP S.472651 201032 at blood vessel epicardial Substance VES S.221 660 22.3853 at BMS1-like, ribosome assembly protein (yeast) MS1L, S.10848 203082 at Bobby sox homolog (Drosophila) BX S.124366 1557240 a. at bobby Sox homolog (Drosophila) BX S.124366 223135 s at bobby Sox homolog (Drosophila) BX S.124366 232008 s at bol, boule-like (Drosophila) OLL S.169797 236954 at bone morphogenetic protein receptor, type IA MPR1A S.S24477 213578 at brain abundant, membrane attached signal protein 1 ASP1 S.2O1641 202391 at brain acyl-CoA hydrolase ACH S.126137 208002 s at brain and reproductive organ-expressed RE S.258.314 205550 s at (TNFRSF1A modulator) brain protein 16 LOCS1236 S.30O224 219071 x at brain protein 44-like BRP44L S.172755 218024 at brain protein I3 BRI3 S.410497 223376 s at branched chain aminotransferase 1, cytosolic BCAT1 S.438993 2265.17 at breakpoint cluster region i? similar to breakpoint BCR if S.S31306 226602 s at cluster region isoform 1 LOC44082O breast carcinoma amplified sequence 1 BCAS1 S.400556 204378 at breast carcinoma amplified sequence 2 BCAS2 S.22960 203053 at BRF2, subunit of RNA polymerase III transcription BRF2 S.274136 218955 at initiation factor, BRF1-like US 2006/01992.04 A1 Sep. 7, 2006 12

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID bromodomain adjacent to Zinc finger domain, 1A BAZ1A S. SO9140 217985 S at Bromodomain adjacent to Zinc finger domain, 1B BAZ1B S. 488671 1569444 at bromodomain containing 2 BRD2 S. 75243 208685 X at bromodomain containing 2 BRD2 S. 75243 214911 s at bromodomain containing 3 BRD3 S. 522472 203825 a. Bromodomain containing 3 BRD3 S. 522472 212547 a bromodomain containing 4 BRD4. S. 202102 s at Bromodomain containing 4 BRD4. 232551 a bromodomain containing 8 BRD8 202227 s at bruno-like 5, RNA binding protein (Drosophila) BRUNOLS 230497 a bruno-like 6, RNA binding protein (Drosophila) BRUNOL6 227775 a BS 3076 1555823 at BS 3076 1555824 a at BTAF1 RNA polymerase II, B-TFIID transcription BTAF1 2094.30 a. actor-associated, 170 kDa (Mot1 homolog, S. cerevisiae) BTB (POZ) domain containing 14B BTBD14B 215587 X at BTB (POZ) domain containing 15 BTBD15 1554469 at BTB (POZ) domain containing 15 BTBD15 226148 a BTB (POZ) domain containing 5 BTBDS 235727 a BTB (POZ) domain containing 6 BTBD6 225389 a BTB (POZ) domain containing 9 BTBD9 233041 x at BTB and CNC homology 1, basic leucine zipper BACH1 210818 S at transcription factor 1 BTB and CNC homology 1, basic leucine zipper BACH1 S. 54276 234315 a. transcription factor 1 BTB and CNC homology 1, basic leucine zipper BACH2 S. 269764 236796 a transcription factor 2 BUB3 budding uninhibited by benzimidazoles 3 BUB3 S. 418533 201456 S at homolog (yeast) BUB3 budding uninhibited by benzimidazoles 3 BUB3 S. 418533 209974 S at homolog (yeast) bubblegum related protein BGR S. 46572O 221716 s at Butyryl Coenzyme A synthetase 1 S. 306812 234643 x at C114 SLIT-like testicular protein S. 463264 1569180 at C114 SLIT-like testicular protein S. 463264 1569181 X at C114 SLIT-like testicular protein LOC474170 S. 463264 233519 a C1q and tumor necrosis factor related protein 3 fif C1OTNF3 S. 171929 220988 s at C1q and tumor necrosis factor related protein 3 Cadherin 11, type 2, OB-cadherin (osteoblast) DH11 S. 116471 239286 a cadherin, EGF LAG seven-pass G-type receptor 2 ELSR2 S. 57652 204029 a (flamingo homolog, Drosophila) cadherin-like 26 S. 54973 233391 a calcitonin gene-related peptide-receptor S. 3OO684 203898 a component protein calcium and integrin binding family member 2 S. 129867 2050.07 s at calcium binding protein 39-like S. 871.59 225914 S at calcium channel, voltage-dependent, P/O type, S. 4084,49 214933 a alpha 1A subunit calcium homeostasis endoplasmic reticulum S. 38646S 1568.704 a at protein calcium modulating ligand S. 52.9846 203538 a calcium calmodulin-dependent protein kinase II S. 197922 218309 a calcium calmodulin-dependent protein kinase IV S. 22O629 241871 a calcium calmodulin-dependent serine protein S. 495984 211208 s at kinase (MAGUK family) calcium-binding tyrosine-(Y)-phosphorylation S. S11983 219928 s at regulated (fibrousheathin 2) calcium-binding tyrosine-(Y)-phosphorylation CABYR S. S11983 224279 s at regulated (fibrousheathin 2) caldesmon 1 CALD1 S. 4902O3 205525 at caldesmon 1 CALD1 S. 4902O3 212077 at calmin (calponin-like, transmembrane) CLMN S. 301.478 221042 s at calmodulin 1 (phosphorylase kinase, delta) CALM1 S. 282410 209563 x at calmodulin 2 (phosphorylase kinase, delta) CALM2 S. 468442 207243 s at Calmodulin 2 (phosphorylase kinase, delta) CALM2 S. 468442 229571 at Calmodulin 2 (phosphorylase kinase, delta) CALM2 S. 468442 235190 at calmodulin binding transcription activator 1 CAMTA1 S. 3977.05 1555370 a. at calmodulin binding transcription activator 1 CAMTA1 S. 3977.05 225692 at calmodulin binding transcription activator 2 CAMTA2 S. 373952 212948 at calmodulin regulated spectrin-associated protein 1 CAMSAP1 S. S22493 212710 at US 2006/01992.04 A1 Sep. 7, 2006 13

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID calnexin CANX S.S29890 208852 s at calnexin CANX S.S29890 208853 S at calnexin calnexin CANX S.S29890 200068 s at calpain 2, (mII) large subunit CAPN2 S.350899 214888 at calpain 3, (p94) CAPN3 S.143261 210944 S at Calpain 7 CAPN7 S.7145 239778 X at calpastatin CAST S.44O961 207467 X at calsequestrin 1 (fas -twitch, skeletal muscle) CASQ1 S.SS2568 219645 at cAMP responsive e ement binding protein 1 CREB1 S.S16646 204313 s at cAMP responsive e ement binding protein 1 CREB1 S.S16646 204314 S at cAMP responsive e ement binding protein 3-like 2 CREB3L2 S.490273 212345 s at cAMP responsive e ement modulator CRE S.2OO2SO 228.092 at cancer Susceptibility candidate 1 CASC1 S4O7771 2201.68 at cancer Susceptibility candidate 2 CASC2 S.89387 1564372 s at cancer Susceptibility candidate 5 CASCS S.181855 228323 at CAP, adenylate cyclase-associated protein 1 CAP1 S.370581 213798. S. at (yeast) CAP-binding protein complex interacting protein 1 FLU23588 S.368507 1562815 at capping protein (actin filament) muscle Z-line, CAPZA1 S.514934 208.374 S at alpha 1 capping protein (actin filament) muscle Z-line, CAPZA2 S.44.6123 201238 s at alpha 2 capping protein (actin filament) muscle Z-line, CAPZA3 S.131288 236888 a alpha 3 capping protein (actin filament) muscle Z-line, beta CAPZB S.432760 37012 at carbamoyl-phosphate synthetase 1, mitochondrial CPS1 S.149252 204920 a carbohydrate (chondroitin) synthase 1 CHSY1 S.110488 203044 a carbohydrate (N-acetylglucosamine 6-O) CHSTS S.42O796 64900 at Sulfotransferase 5 i? hypothetical protein MGC15429 MGC15429 carbonic anhydrase II A2 S.155097 209301 a carbonic anhydrase XII A12 S.210995 203963 a carbonic reductase 4 BR4 S.481166 1553693 s at Carbonic reductase 4 BR4 S.481166 2323.47 x at carboxylesterase 2 (intestine, liver) ES2 S.282975 209668 x at carcinoembryonic antigen-related cell adhesion EACAMS S.220529 201884 a molecule 5 carcinoembryonic antigen-related cell adhesion EACAM6 S.466814 211657 a molecule 6 (non-specific cross reacting antigen) if carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) carcinoembryonic antigen-related cell adhesion CEACAM7 S.74466 206199 a molecule 7 Cardiotrophin-like cytokine factor 1 LC S.SO2977 1556385 at carnitine acetyltransferase RAT S.12O68 209522 s at carnitine deficiency-associated, expressed in DV1 S.S28382 219372 a. ventricle 1 carnitine O-octanoyltransferase CROT 204573 a carnitine palmitoyltransferase 1A (liver) CPT1A 203634 S. at Cas-Br-M (murine) ecotropic retroviral transforming CBLB 209682 a sequence b casein kinase 1, alpha 1 S.442592 208865 a. casein kinase 1, alpha 1 S.442592 208866 a casein kinase 1, alpha 1 S.442592 21308.6 s at casein kinase 1, alpha 1 S.442592 2138.60 x at casein kinase 1, gamma 1 S.25433S 221673 s at casein kinase 1, gamma 2 S.181390 202573 a casein kinase 1, gamma 3 S.1292O6 22O768 s at Casein kinase 1, gamma 3 S.1292O6 227767 a casein kinase 2, alpha prime polypeptide S.822O1 203575 a Casein kinase 2, alpha prime polypeptide 224922 a CASP2 and RIPK1 domain containing adaptor with S.38533 1563706 at death domain CASP2 and RIPK1 domain containing adaptor with CRADD S.38533 209833 a death domain CASP8 and FADD-like apoptosis regulator CFLAR S.390.736 211316 x at CASP8 and FADD-like apoptosis regulator CFLAR S.390.736 2396.29 a CASP8 and FADD-like apoptosis regulator fif CFLAR S.390.736 209508 X at CASP8 and FADD-like apoptosis regulator US 2006/01992.04 A1 Sep. 7, 2006 14

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID caspase 2, apoptosis-related cysteine protease CASP2 S.368,982 208050 s at (neural precursor cell expressed, developmentally down-regulated 2) caspase 2, apoptosis-related cysteine protease CASP2 S.368,982 226032 at (neural precursor cell expressed, developmentally down-regulated 2) caspase 6, apoptosis-related cysteine protease CASP6 S.328O 211464 X at caspase 9, apoptosis-related cysteine protease CASP9 S.3295O2 203984 S at caspase 9, apoptosis-related cysteine protease CASP9 S.3295O2 210775 X at caspase recruitment domain family, member 10 CARD10 S.57973 210026 s at cat eye syndrome chromosome region, candidate 5 CECR5 S.26890 218592 s at catalase CAT S.SO23O2 2014.32 at Catenin (cadherin-associated protein), alpha 1, CTNNA1 S.445981 24O262 at 102 kDa catenin (cadherin-associated protein), alpha 2 CTNNA2 S.167368 205373 at catenin (cadherin-associated protein), alpha-like 1 CTNNAL1 S.S8488 202468 s a Catenin (cadherin-associated protein), beta 1, CTNNB1 S.476O18 223679 at 88 kDa catenin (cadherin-associated protein), delta 2 CTNND2 S.314543 209617 s a (neural plakophilin-related arm-repeat protein) cathepsin B CTSB S.S2O898 213274 S a cathepsin K (pycnodysostosis) CTSK S.S23594 202450 s a cathepsin O CTSO S.75262 2O3758 at cation channel, sperm associated 2 CATSPER2 S.389181 217588 at CCAAT enhancer binding protein(C/EBP), beta CEBPB S.S17106 212501 at CCAAT enhancer binding protein zeta CEBPZ. S.1354O6 229746 x a CCR4-NOT transcription complex, subunit 1 CNOT1 S.460923 2008.60 S a CCR4-NOT transcription complex, subunit 2 CNOT2 S.1333 SO 222182 S a CCR4-NOT transcription complex, subunit 2 CNOT2 S.1333 SO 244197 x a CCR4-NOT transcription complex, subunit 3 CNOT3 S.343571 229143 at CCR4-NOT transcription complex, subunit 6-like CNOT6L S.183O85 226153 s a CCR4-NOT transcription complex, subunit 7 CNOTT S.17OSS3 218250 s a CCR4-NOT transcription complex, subunit 8 CNOT8 S.26703 202162 s a CD109 antigen (Gov platelet alloantigens) D109 2299.00 at CD164 antigen, sialomucin D164 2084.05 s a CD164 antigen, sialomucin D164 208653 s a C D164 antigen, sialomucin D164 208654 S a C D2 antigen (p50), sheep red blood cell receptor D2 205831 at // CD2 antigen (p50), sheep red blood cell receptor CD24 antigen (Small cell lung carcinoma cluster 4 D24 S.37S108 208.650 s a antigen) CD24 antigen (Small cell lung carcinoma cluster 4 CD24 S.37S108 209771 x a antigen) CD24 antigen (Small cell lung carcinoma cluster 4 CD24 S.37S108 216379 x a antigen) CD24 antigen (Small cell lung carcinoma cluster 4 CD24 S.37S108 266 s at antigen) D274 antigen CD274 S.S21989 223834 at D27-binding (Siva) protein SIVA S.112058 222030 at D36 antigen (collagen type I receptor, CD36 S.120949 236923 x at rombospondin receptor D40 antigen (TNF receptor Superfamily member CD40 S.4728.60 35150 at D47 antigen (Rh-related antigen, integrin CD47 S.446414 213857 s at associated signal transducer) CD47 antigen (Rh-related antigen, integrin CD47 S.446414 211075 s at associated signal transducer) if CD47 antigen (Rh-related antigen, integrin-associated signal transducer) CD53 antigen CD53 S.443.057 203416 at CD58 antigen, (lymphocyte function-associated CD58 S.34341 243931 at antigen 3) CD59 antigen p18–20 (antigen identified by CD59 S.278573 200983 x at monoclonal antibodies 16.3A5, EJ16, E.J30, EL32 and G344) CD59 antigen p18–20 (antigen identified by CD59 S.278573 200984 S at monoclonal antibodies 16.3A5, EJ16, E.J30, EL32 and G344) CD80 antigen (CD28 antigen ligand 1, B7-1 S.838 20717.6 s at antigen) US 2006/01992.04 A1 Sep. 7, 2006 15

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID D9 antigen (p24) S.114286 201005 at D99 antigen S.49560S 201029 s a DC14 cell division cycle 14 homolog A (S. cerevisiae) S.S33582 243640 x a DC14 cell division cycle 14 homolog B (S. cerevisiae) S.40582 221555 x a DC14 cell division cycle 14 homolog B (S. cerevisiae) S.40582 221556 at DC14 cell division cycle 14 homolog B (S. cerevisiae) S.40582 234605 at DC14 cell division cycle 14 homolog B (S. cerevisiae) S.40582 208022 s a fit CDC14 cell division cycle 14 homolog B (S. cerevisiae) DC16 cell division cycle 16 homolog (S. cerevisiae) S.374127 202717 s a DC23 (cell division cycle 23, yeast, homolog) S.153546 202892 at DC28 protein kinase regulatory subunit 1B S.374378 201897 s a DC28 protein kinase regulatory subunit 2 S.837.58 204170 s a DC2-relate protein kinase 7 S.416108 213557 at DC2-relate protein kinase 7 S.416108 219226 at DC42 binding protein kinase alpha (DMPK-like) S.3S433 214464 at DC42 effector protein (Rho GTPase binding) 3 S.369574 225685 at DC42 smal effector 1 S.22O65 222537 s a DC42 smal effector 1 S.22O65 229120 s a DC5 cell division cycle 5-like (S. pombe) S.4854.71 209056 S a DC5 cell division cycle 5-like (S. pombe) S.4854.71 209057 X a DC-like kinase 1 CDC-like kinase 4 S.433732 210346 s a

DC-like kinase 4 S.406557 241403 at DK2-associated protein 1 S.4332O1 201938 at DNA clone MAG : 2988896 S.158545 566228 a DNA clone MAG : 3346533, containing frame S.478854 ift errors DNA clone MAG : 354272O S.S47037 DNA clone MAG : 3895112, containing frame S.SS2683 57016s a hift errors DNA clone MAG : 3944752, partia S.437283 555206 a DNA clone MAG : 4151535, partia S.S35917 560826 a DNA clone MAG : 4288461, partia S.27OO98 DNA clone MAG : 4333O81, partia S.336989 DNA clone MAG :4557810, partia S.98587 DNA clone MAG : 4620359, partia S.418.285 568813 a DNA clone MAG : 4698949, partia S.551727 234020 x at DNA clone MAG : 4753178, contai S.SS2097 570567 a ift errors DNA clone MAG : 4791593, partia S.1478.78 5591.02 a DNA clone MAG : 4792502, partia S.283396 DNA clone MAG : 4795866, partia S.S13661 DNA clone MAG : 4796102, partia S.S39926 561604 a DNA clone MAG : 4797120, partia S.S37004 226671 at DNA clone MAG : 4815736, partia S.21816 2284.94 at DNA clone MAG : 4829245, S.130189 231485 at DNA clone MAG : 4841343, S.86508 230672 at DNA clone MAG : 5169389, S.380689 237794 at etained intron DNA clone MAG : 5206119, S.318639 238953 at s DNA clone MAG : 52.17021, S.SSO698 221973 at etained intron DNA clone MAG : 5243069, S.S3SSOO 212049 at DNA clone MAG : 5259778, S.97129 236349 at DNA clone MAG : 5263531, S.399763 224778 s at DNA clone MAG : 52651.99, S.S38599 15665.04 at DNA clone MAG : 5265356, S.180330 1556976 S. at DNA clone MAG : 5265747, S.1264.05 1555995 a. at DNA clone MAG : 5266242, S.1870.18 238.559 at DNA clone MAG : 5266307, S.S2O453 1557891 S. at DNA clone MAG : 5266689, S.140444 241.144 at DNA clone MAG : 5268125, S.461412 1560957 at DNA clone MAG : 5272727, S.379472 1566.809 a. at DNA clone MAG : 5277089, S.S471SO 238244 at DNA clone MAG : 5277680, S.38.1993 1566,763 at DNA clone MAG : 5286005, S.S.49531 2423.64 x at DNA clone MAG : 5286843, S.3O2631 235174 S at DNA clone MAG : 5287121, S.37S744 243904 at DNA clone MAG : 5295.357, S.382O12 1560954 at DNA clone MAG : 5296106, S.5483O1 1556834 at

US 2006/01992.04 A1 Sep. 7, 2006 17

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set DNA FLJ40764 fis, clone TRACH2002954 S.482589 1562009 a. at DNA FLJ40901 fis, clone UTERU2003704 S.44898 227663 a DNA FLJ41270 fis, clone BRAMY2036387 S.445414 228528 a DNA FLJ41452 fis, clone BRSTN2010363 S.S30543 227922 x at DNA FLJ42077 fis, clone SYNOV201928O S.444521 236776 a DNA FLJ42310 fis, clone TRACH2007733 S.444400 239718 a DNA FLJ42313 fis, clone TRACH2O19425 S.386O42 235028 a DNA FLJ42357 fis, clone UTERU2022773 S.S47723 216527 a DNA FLJ43181 fis, clone FCBBF3016134 S.98SS3 243.007 a DNA FLJ45384 fis, clone BRHIP3021987 S. 61558 229699 a DNA FLJ46224 fis, clone TESTI4014262 S.542318 240507 a DNA FLJ90571 fis, clone OVARC1001725, highly S.23754 227745 a. milar to Homo sapiens patched related protein RC8 (TRC8) gene. DNA sequence BCO22357 BCO22357 224957 a DNA: FLJ20874 fis, clone ADKAO2818 S.S39236 216739 a DNA: FLJ20891 fis, clone ADKAO3345 S.S37488 1566954 at DNA: FLJ20892 fis, clone ADKAO3430 S.386421 230683 a DNA: FLJ20908 fis, clone ADSE00417 S.S.45857 216730 a. DNA: FLJ20946 fis, clone ADSEO1819 S.3066.96 233702 X at DNA: FLJ20949 fis, clone ADSEO1902 S.380443 222207 x at DNA: FLJ21226 fis, clone COLOO721 S.SSO156 216751 a DNA: FLJ21228 fis, clone COLOO739 S.306716 234723 x at DNA: FLJ21452 fis, clone COLO4505 S.502812 232476 a DNA: FLJ21881 fis, clone HEPO2746 S.SSO197 232876 a DNA: FLJ22144 fis, clone HEP21732 S.413944 233428 a DNA: FLJ22256 fis, clone HRCO2860 S.288741 214036 a DNA: FLJ22539 fis, clone HRC13227 S.17519 227491 a DNA: FLJ22769 fis, clone KAIA1316 232781 a DNA: FLJ22994 fis, clone KAT11918 227792 a. DNA: FLJ23566 fis, clone LNG10880 S.S32596 234675 X at DP-diacylglycerol synthase (phosphatidate S.444924 2261.85 a cytidylyltransferase) 1 CDP-diacylglycerol-inositol 3 DIPT S.121549 2012.53 s at phosphatidyltransferase (phosphatidylinositol synthase) cell death-regulatory protein GRIM19 RIM19 S.S34453 2208.64 S at cell division cycle 25A DC25A HS.1634 1555.772 a. at cell division cycle 26 DC26 S.53O284 225422 at cell division cycle 27 DC27 S.463295 217879 at cell division cycle 2-like 1 (PITSLRE ) f/ DC2L1 S.192316 212401 S. at cell division cycle 2-like 2 (PITSLRE proteins) Cell division cycle 2-like 5 (cholinesterase-related S.233552 232266 x at cell division controller) cell division cycle 2-like 6 (CDK8-like) DC2L6 S.193251 212899 a cell division cycle 2-like 6 (CDK8-like) DC2L6 S.193251 235.226 a cell division cycle 37 homolog (S. cerevisiae)-like 1 DC37L1 S.493.361 219343 a cell division cycle 40 homolog (yeast) DC4O S.428147 203377 s at cell division cycle and apoptosis regulator 1 CAR1 S.49853 224736 a cell division cycle associated 3 DCA3 S.524216 223307 a cell growth regulator with ring finger domain 1 GRRF1 S.591O6 204605 a Centaurin, beta ENTB1 S.337242 242081 a Centaurin, beta 2 ENTB2 S.478.746 240759 a centaurin, gamma 2 ENTG2 S.43SO39 204066 s at Centaurin, gamma-like family, member 1 TGLF1 S.4994.96 1565620 at centaurin, gamma-like family, member 1 TGLF1 S.4994.96 221850 x at protein J ENPJ S.S33828 2235.13 a centrosome protein cep290 S.150444 205250 S at centrosome protein Cep63 S.4433O1 222151 s at centrosome spindle pole associated protein S.3701.47 220072 a centrosome spindle pole associated protein S.3701.47 242041 a centrosome-associated protein 350 CAP3SO S.413045 204373 s at centrosome-associated protein 350 CAP3SO S.413045 213956 a cerebellin 1 precursor CBLN1 S.458423 205747 a cereblon CRBN S.18925 222533 a ceroid-lipofuscinosis, neuronal 5 CLNS 20408.4 S at CGO16 LOC88523 214748 a CG10806-like LOC15O159 S.445.192 1553633 S at CG10806-like LOC15O159 S.445.192 1555141 a. at CGG triplet repeat binding protein 1 CGGBP1 S.444818 224600 a US 2006/01992.04 A1 Sep. 7, 2006 18

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID CGI-119 protein CGI-119 S.SOS934 219206 x at CGI-119 protein CGI-119 S.SOS934 222845 x at CGI-119 protein CGI-119 S.SOS934 223892 s at CGI-146 protein PNAS-4 S.498.317 1558914 at CGI-146 protein PNAS-4 S.498.317 212371 at CGI-146 protein PNAS-4 S.498.317 221648 s at CGI-146 protein PNAS-4 S.498.317 22215.8 s at CGI-96 protein it? similar to CGI-96 CGI-96 S.550515 202938 x at J222E13.2 CHS400 S.32S100 2374.75 X at chaperonin containing TCP1, Subunit 2 (beta) CCT2 S.189772 201947 s at chaperonin containing TCP1, subunit 6B (Zeta 2) CCT6B S.73072 206587 a chaperonin containing TCP1, subunit 8 (theta) CCT8 S.1251.13 200873 s at Chaperonin containing TCP1, subunit 8 (theta) CCT8 S.1251.13 242380 a Chemokine (C-C motif) ligand 27 CCL27 S.459590 230327 a chemokine (C-X-C motif) ligand 1 (melanoma CXCL1 S.789 204470 a rowth stimulating activity, alpha) hemokine (C- X-C motif) ligand 10 CXCL10 S.413924 204533 a hemokine (C- X-C motif) ligand 12 (Stromal cell CXCL12 S.522891 203666 a erived factor 1) hemokine orphan receptor 1 CMKOR1 S.471751 212977 a hemokine-like factor Super family 1 CKLFSF1 S.549232 231219 a hemokine-like factor Super family 2 CKLFSF2 S.195685 229967 a hemokine-like factor Super family 6 CKLFSF6 S.380627 217947 a chemokine-like factor Super family 6 CKLFSF6 S.380627 223047 a CHK1 checkpoint homolog (S. pombe) CHEK1 S.24529 205394 a Chloride channel 3 CLCN3 S.481186 201734 a hloride channel, nucleotide-sensitive, 1A CLNS1A S.107393 209143 s at hromosome 3 open reading frame 4 C3orfA. holine dehydrogenase CHDH S.126688 1559591 S. at holine kinase beta i? carnitine CHKB S.439777 210069 a almitoyltransferase 1B (muscle) CPT1B holine kinase beta i? carnitine CHKB S.439777 210070 s at almitoyltransferase 1B (muscle) CPT1B holine phosphotransferase CHPT1 S.293.077 221675 s at hondroitin sulfate GalNAcT-2 GALNACT-2 S.180758 218871 x at hondroitin Sulfate proteoglycan 2 (versican) CSPG2 S.443681 204620 S at hondroitin Sulfate proteoglycan 2 (versican) CSPG2 S.443681 221731 x at hondroitin Sulfate proteoglycan 6 CSPG6 S.24485 209259 S at hromobox homolog 1 (HP1 beta homolog CBX1 S.772S4 201518 at Drosophila) chromobox homolog 3 (HP1 gamma homolog, S.381189 201091 s at Drosophila) chromobox homolog 3 (HP1 gamma homolog, S.381189 200037 s at Drosophila) i? chromobox homolog 3 (HP1 gamma homolog, Drosophila) chromobox homolog 4 (Pc class homolog, S.405046 227558 at Drosophila) chromobox homolog 5 (HP1 alpha homolog, S.349283 209715 at Drosophila) chromobox homolog 6 BX6 S.S11952 202047 s at chromodomain helicase DNA binding protein 1 HD S.5.19474 204258 at Chromodomain helicase DNA binding protein 1 HD S.5.19474 235791 X at chromodomain helicase DNA binding protein 1-like HD1 L, S.191164 212539 at chromodomain helicase DNA binding protein 2 HD2 S.546244 1554014 at chromodomain helicase DNA binding protein 5 HDS S.522898 217250 s at C hromodomain helicase DNA binding protein 9 HD9 S.S30936 212616 at C hromodomain helicase DNA binding protein 9 HD9 S.S30936 229586 at Chromodomain protein, Y-like DYL S.269092 240594 at hromodomain protein, Y-like 2 DYL2 S.373908 1553647 at hromosome 1 open reading frame 16 orf16 s. 270775 201794 S at hromosome 1 open reading frame 16 orf16 s. 270775 21718.9 s at hromosome 1 open reading frame 22 orf22 S.523811 223243 s at hromosome 1 open reading frame 24 orf24 S.518662 217967 s at hromosome 1 open reading frame 25 orf25 S.1071.49 223404 S at hromosome 1 open reading frame 34 orf34 S.112949 210652 s at hromosome 1 open reading frame 37 orf37 S.497443 212165 at chromosome 1 open reading frame 43 orf243 S.287.471 223034 S at Chromosome 1 open reading frame 43 orf243 S.287.471 233248 at chromosome 1 open reading frame 48 orf248 S.497692 2094.84 S at US 2006/01992.04 A1 Sep. 7, 2006 19

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Chromosome 1 open reading frame 48 orfA8 S.497692 235799 a C OOSOc open reading frame 8 orf3 S.S23262 200620 a C OOSOc open reading frame 9 orf S.204559 203429 s at C OOSOc el (8 ing rame 103 Oorf103 1557827 at C OOSOc el (8 ing rame 104 Oorf104 S.426296 224664 a C OOSOc el (8 ing rame 104 Oorf104 S.426296 224667 x at C OOSOc el (8 ing rame 104 Oorf104 S.426296 229145 a. Chromosome 10 open reading frame 116 Oorf116 S.7412O 232300 a OOSOc el (8 ing rame 118 Oorf118 S.159066 219844 a OOSOc el (8 ing rame 12 Oorf12 S.14SSS 226892 a OOSOc el (8 ing rame 128 Oorf128 S385493 1561890 at OOSOc el (8 ing rame 137 Oorf137 S.468688 213410 a OOSOc el (8 ing rame 22 0orf22 S.998.21 212500 a OOSOc el (8 ing rame 22 0orf22 S.998.21 212502 a OOSOc el (8 ing rame 35 Oorf3S S.S22992 226313 a OOSOc el (8 ing rame 45 Oorf245 S.446315 223.058 a OOSOc el (8 ing rame 45 Oorf245 S.446315 223059 is at OOSOc el (8 ing rame 51 Oorf51 S.S2996S 231196 X at OOSOc el (8 ing rame 53 Oorf53 S.131287 239998 a OOSOc el (8 ing rame 58 Oorf58 S.SOO333 22815S a OOSOc el (8 ing rame 59 Oorf59 S.149849 223824 a Chromosome 10 open reading frame 61 Oorf61 S.438991 244347 a OOSOc el (8 ing rame 65 Oorf6S S.18O346 239093 a OOSOc el (8 ing rame 68 Oorf68 220749 a OOSOc el (8 ing rame 70 Oorf70 S.3701 O2 218597 s a OOSOc el (8 ing rame 78 Oorf78 S.93667 236027 a OOSOc el (8 ing rame 82 Oorf&2 S.121347 231609 a OOSOc el (8 ing rame 84 Oorf&4 S.372309 222617 s a OOSOc el (8 ing rame 9 0orf S.14745 224651 a OOSOc el (8 ing rame 9 0orf S.14745 224652 a OOSOc el (8 ing rame 17 1orf7 S.13118O 220987 s a OOSOc el (8 ing rame 17 i? likely rtholog of ra P-activated protein kinase S NARK fit likely ortholog of rat SNF1, AMP-activated rotein kinase OOSOc el (8 ing 2Orf11 S.505.077 221652 s a OOSOc el (8 ing 2Orf2 S.26994.1 235996 a OOSOc el (8 ing 2Or S.3O2977 21837.4 S a OOSOc el (8 ing 2Or S.3O2977 22613 a OOSOc el (8 ing 3orf10 S.131715 8422 S a OOSOc el (8 ing 3orf10 S.131715 22626 a Chromosome 13 open reading 3Sorf10 S.131715 29433 a C OOSOc el (8 ing 3orf11 S.317593 20241 a C OOSOc el (8 ing 3orf12 S.268742 7769 s a C OOSOc el (8 ing 3orf22 S.S33831 O4190 a C OOSOc el (8 ing 3orf S.88523 27165 a C OOSOc el (8 ing 4orf101 S.S49170 9757 is a C OOSOc el (8 ing 4orf101 S.S49170 25675 a. Chromosome 14 open reading 4orf103 S.168241 26684 a C OOSOc 4 o el (8 ing 4orf108 S.S28653 8139 s a C OOSOc 4 o el (8 ing 4orf111 S.343173 5567 a Chromosome 14 open reading 4orf112 S.1371.08 7645 a. C OOSOc 4 o el (8 ing 4orf118 S.410231 29520 s a Chromosome 14 open reading 4orf119 S.S2S238 43249 a C OOSOc el (8 ing 4orf131 S.106OOS 9086 a C OOSOc el (8 ing 4orf143 S.123232 214264 S a C OOSOc el (8 ing 4orf148 S.97.556 231566 a C OOSOc el (8 ing 4orf150 S.4973O1 238,650 x a Chromosome 14 open reading 4orf153 S.116O29 232814 x a C OOSOc el (8 ing 4orf154 S.S104O7 229940 a OOSOc el (8 ing 4orf156 S.324521 221434 S a OOSOc el (8 ing OOSOc el (8 ing S.1317SS 220293 a OOSOc el (8 ing S.S34457 217768 a OOSOc el (8 ing S.509916 219526 a OOSOc el (8 ing S.298.227 232316 a OOSOc el (8 ing S.437831 212643 a OOSOc el (8 ing S.165465 225679 a OOSOc el (8 ing S.17926O 223474 a OOSOc el (8 ing S.SO9923 225980 a OOSOc el (8 ing S.26OSSS 220173 a US 2006/01992.04 A1 Sep. 7, 2006 20

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Chromosome 14 open reading frame 46 4or 246 S.S13392 242409 a hromosome 14 o el (8 ing rame 48 4or 248 S.14384.5 15701 11 at hromosome 14 o el (8 ing rame 49 4or 249 S.354645 1553644 at hromosome 14 o el (8 ing rame SO 4or SO S.144696 237654 a hromosome 14 o el (8 ing rame 58 4or S8 S.509966 2228.66 s at hromosome 14 o el (8 ing rame 8 4or S.406,966 231140 a hromosome 14 o el (8 ing rame 92 4or 92 S.194035 201684 S at hromosome 15 o el (8 ing rame 23 Sor 23 S.S2S796 225300 a hromosome 15 o el (8 ing rame 25 Sor 25 S.14347 220071 x at hromosome 15 o el (8 ing rame 27 Sor 27 S.458.96S 1552400 a. at hromosome 15 o el (8 ing rame 29 Sor 29 SS10938 1559658 at hromosome 16 o el (8 ing rame 34 6or 34 S.513261 212109 a hromosome 16 o el (8 ing rame 34 6or 34 S.513261 212115 a. hromosome 16 o el (8 ing rame 45 6or A5 S.46OO95 212736 a hromosome 16 o el (8 ing rame 46 6or 246 S.2O3594 230281 a hromosome 16 open reading frame 46 LJ32702 S.2O3594 232696 a hromosome 16 o el (8 ing rame 5 S S.7765 223960 S at hromosome 16 o el (8 ing rame 52 52 S.549248 230721 a hromosome 16 o el (8 ing rame 55 55 S.43S398 230811 a hromosome 17 o el (8 ing rame 39 39 S.187422 220058 a hromosome 17 o el (8 ing rame 39 39 S.187422 2284.52 a hromosome 18 o el (8 ing rame 10 O S.22981 212055 a. hromosome 18 open reading frame 11 1 S.444314 237262 a hromosome 18 o el (8 ing rame 2 2 S.464442 223977 S at hromosome 18 o el (8 ing rame 22 22 S.S32987 243001 a hromosome 18 o el (8 ing rame 23 23 S.5O1114 1557545 s at hromosome 18 o el (8 ing rame 23 23 S.5O1114 23.0143 a hromosome 18 o el (8 ing rame 37 37 S.464903 1559716 at hromosome 18 o el (8 ing rame 45 A5 S.137562 244495 x at hromosome 18 o el (8 ing rame 45 A5 S.137562 224493 x at hromosome 18 o el (8 ing rame 45 hromosome 18 o el (8 ing rame 54 S 4 S.208701 229442 at hromosome 18 o el (8 ing rame 8 S.529OO6 221190 s. at hromosome 18 o el (8 ing rame 9 S.236940 52285 f at hromosome 19 open reading frame 2 S.466391 222266 at hromosome 19 o el (8 ing rame 22 2 S388.956 55705 at hromosome 19 o el (8 ing rame 6 S.S1SOO3 213986 s at hromosome 19 o el (8 ing rame 7 S.104661 213390 at hromosome 2 open reading frame 11 S.3SO388 238,955 at hromosome 2 open reading frame 16 S.131021 224000 at hromosome 2 open reading frame 17 S.S16707 221983 at hromosome 2 open reading frame 17 S.S16707 221984 S at hromosome 2 open reading frame 29 S.3O819 224695 at hromosome 2 open reading frame 3 S.3O38O8 216305 S at hromosome 2 open reading frame 33 S.471528 219137 s at hromosome 2 open reading frame 33 S.471528 222832 S at hromosome 2 open reading frame 33 S.471528 223091 x at hromosome 2 open reading frame 33 S.471528 223354 x at hromosome 2 open reading frame 4 S.444969 219065 s at hromosome 2 open reading frame 4 S.444969 243O88 a hromosome 20 o el (8 ing O S.4O1982 207482 a hromosome 20 o el (8 ing O6 S.SO4907 233O86 a hromosome 20 o el (8 ing O8 S.143736 224690 a hromosome 20 o el (8 ing 1 S.3S3013 218448 a hromosome 20 o el (8 ing 11 11 S.7S798 209020 a hromosome 20 open reading 111 11 221954 a hromosome 20 o el (8 ing 12 12 S.S16977 225224 a hromosome 20 o el (8 ing 28 28 S.SS2605 1556793 a at hromosome 20 o el (8 ing 29 29 S.472716 225687 a hromosome 20 o el (8 ing 41 41 S.3521.87 1554042 s at hromosome 20 o el (8 ing 55 55 S.224764 223978 S at hromosome 20 o el (8 ing 60 60 S.3821.51 1570070 at hromosome 20 open reading 17 S473117 235815 a. hromosome 20 o el (8 ing 73 73 S.15868O 233143 a hromosome 20 o el (8 ing 8 S.24728O 221827 a hromosome 20 o el (8 ing 9 S.18763S 228291 s at hromosome 20 o el (8 ing 94 94 S.S16853 225825 a. hromosome 20 o el (8 ing rame 22 22 S.441.5SO 2281.23 s at hromosome 20 o el (8 ing rame 24 24 S.184O62 217835 X at hromosome 20 o el (8 ing rame 24 24 S.184O62 223880 x at Chromosome 20 open reading frame 26 26 S.176O13 1564758 at US 2006/01992.04 A1 Sep. 7, 2006 21

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID

hromosome 20 Oeil (8 ing rame 3 S.472330 206656 S at hromosome 20 Oeil (8 ing rame 30 S.472O24 224.584 at hromosome 20 Oeil (8 ing rame 43 S.S17134 217737 x at hromosome 20 Oeil (8 ing rame 43 S.S17134 233842 x at hromosome 20 Oeil (8 ing rame 59 S.512686 232922 s at hromosome 20 Oeil (8 ing rame 6 S.369284 218859 S at hromosome 20 Oeil (8 ing rame 65 S.447626 232820 s at hromosome 20 Oeil (8 ing rame 65 S.447626 232821 a hromosome 20 Oeil (8 ing rame 7 S.4721.65 222894 x at hromosome 20 Oeil (8 ing rame 7 S.4721.65 227160 s at hromosome 20 Oeil (8 ing rame 71 S.360989 240359 a hromosome 20 Oeil (8 ing rame 77 S.278839 225.024 a hromosome 20 Oeil (8 ing rame 79 S.112794 231134 a hromosome 2 Oeil (8 ing rame 106 S.18958S 1555301 a. at hromosome 2 O el (8 ing rame 106 S.18958S 1561286 a. at hromosome 2 O el (8 ing rame 106 S.18958S 215529 X at hromosome 2 O el (8 ing rame 114 1555373 at hromosome 2 O el (8 ing rame 121 S.1438.33 240809 a hromosome 2 Oeil (8 ing rame 13 S.517284 2321.96 a hromosome 21 open reading frame 34 S.473394 23.9999 a hromosome 2 Oeil (8 ing rame 4 S.433668 222907 X at hromosome 2 O el (8 ing rame 42 S.234O16 231303 a hromosome 2 O el (8 ing rame 45 S.190518 219004 S at hromosome 2 O el (8 ing rame 51 S.3O3798 228239 a hromosome 2 O el (8 ing rame 57 S.58668 227421 a hromosome 2 Oeil (8 ing rame 59 HS.5811 218123 a hromosome 21 open reading frame 66 S47363S 1556789 a. at hromosome 2 Oeil (8 ing rame 66 S47363S 221158 a hromosome 21 open reading frame 66 S47363S 2394.07 a hromosome 2 Oeil (8 ing rame 77 S.272236 220826 a hromosome 21 open reading frame 87 S.190548 23.9602 a hromosome 2 Oeil (8 ing rame 91 S.293811 220941 s at hromosome 22 Oeil (8 ing rame 13 HS.98SO 223.039 a hromosome 22 Oeil (8 ing rame 23 S.S17612 22.3706 a hromosome 22 open reading frame 23 S.S17612 243515 a. hromosome 22 Oeil (8 ing rame 9 S.369682 217118 s at hromosome 3 o el 8 ing rame 10 S.S17792 224.575 a. hromosome 3 o el 8 ing rame 14 S.47166 219288 a hromosome 3 o el 8 ing rame 15 S.341906 1561430 s at hromosome 3 o el 8 ing rame 18 S.S17860 219114 a hromosome 3 o el 8 ing rame 22 S.178210 237894 a hromosome 3 o el 8 ing rame 4 S.107393 1554149 at hromosome 3 o el 8 ing rame 6 : S.478.682 225331 a hromosome 4 o el 8 ing rame 8 S.125348 203600 s at hromosome 5 o el 8 ing rame 13 S.483O67 201310 s at hromosome 5 open reading frame 15 S.355.177 243350 a hromosome 5 o el 8 ling rame 3 S.166551 218588 S at hromosome 5 o el 8 ing rame 3 S.166551 222682 s at hromosome 5 o el 8 ing rame 5 S.483473 218518 a hromosome 6 o el 8 ing rame 105 S.1264.09 215100 a hromosome 6 o el 8 ing rame 105 S.1264.09 229070 a hromosome 6 o el 8 ing rame 111 S.S2O287 212179 a hromosome 6 o el 8 ing rame 12 S.302O37 234445 a. hromosome 6 o el 8 ing rame 130 S.549281 213322 a hromosome 6 o el 8 ing rame 130 S.549281 238860 a hromosome 6 o el 8 ing rame 142 S.485588 235377 a hromosome 6 o el 8 ing rame 146 S.546521 237619 a hromosome 6 open reading frame 153 S.309231 1569516 at hromosome 6 o el 8 ling rame 160 225155 a hromosome 6 o el 8 ing rame 163 S.485902 233787 a hromosome 6 o el 8 ing rame 192 S.347144 226301 a hromosome 6 o el 8 ing rame 201 2O1 S.S1985S 231642 a hromosome 6 o el 8 ing rame 209 209 S.271643 218191 s at hromosome 6 o el 8 ing rame 33 33 S.239388 227626 a Chromosome 6 open reading frame 49 A9 S.S2S899 229351 a chromosome 6 o el 8 ling rame 55 55 S.431367 224437 S at chromosome 6 o el 8 ing rame 55 chromosome 6 o el 8 ing rame 62 62 S.S19930 208809 s at Chromosome 6 open reading frame 62 62 S.S19930 213872 a chromosome 6 o el 8 ling rame 64 64 S.S8382 222741 s at chromosome 6 o el 8 ing rame 72 72 S.438872 225576 a US 2006/01992.04 A1 Sep. 7, 2006 22

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID chromosome 6 open reading frame 74 C6orf74 S.32826 203259 S at chromosome 6 open reading frame 82 C6orf2 S.S20070 221488 s at chromosome 6 open reading frame 83 C6orf33 S.4871.43 225849 s at chromosome 6 open reading frame 85 C6orf3S S.132340 223194 S at chromosome 6 open reading frame 85 C6orf3S S.132340 233206 a chromosome 7 open reading frame 11 C7orf11 S.1291.59 225419 a chromosome 7 open reading frame 19 C7orf19 S.3633O8 1558426 X at chromosome 7 open reading frame 24 C7orf24 S.53OO24 21538.0 s at Chromosome 7 open reading frame 24 C7orf24 S.53OO24 2398.41 a chromosome 7 open reading frame 30 C7orf O S.87385 226385 S at chromosome 7 open reading frame 30 C7orf O S.87385 226386 a chromosome 7 open reading frame 31 C7orf1 S.1220SS 229146 a chromosome 7 open reading frame 34 C7orf4 S.239676 231435 a. chromosome 7 open reading frame 35 C7orf35 S.19025 223396 a chromosome 7 open reading frame 6 C7orf6 S.489.118 226603 a Chromosome 7 unknown mRNA S.489.556 1556306 at chromosome 8 open reading frame 1 C8or S.436445 1554414 a at open reading frame 10 C9Crf10 S.372003 200774 a chromosome 9 open reading frame 11 C9orf11 S.163070 1554981 at chromosome 9 open reading frame 11 C9orf11 S.163070 1554982 a. at chromosome 9 open reading frame 11 C9orf11 S.163070 232868 a chromosome 9 open reading frame 116 C9orf116 S.414O28 594.37 at chromosome 9 open reading frame 117 C9Crf117 S.362949 231172 a Chromosome 9 open reading frame 126 C9orf126 S.S9504 233246 a chromosome 9 open reading frame 156 C9Crf156 S.91.96 475.30 at Chromosome 9 open reading frame 3 C9Crf3 S.434253 237716 a chromosome 9 open reading frame 36 C9Crf36 S.123004 215935 a. chromosome 9 open reading frame 36 / similar to C9Crf36 S.123004 215320 a hypothetical protein fit hypothetical LOC441452 LOC441448 DKFZp4 34M131 chromosome 9 open reading frame 41 C9orf241 S.257556 241781 at chromosome 9 open reading frame 45 C9CrfaS S.21379 223522 at chromosome 9 open reading frame 5 C9Crfs S.3O8.074 223005 s at chromosome 9 open reading frame 5 C9Crfs S.3O8.074 223006 s at chromosome 9 open reading frame 58 C9Crf58 S.4944 223.075 S. at chromosome 9 open reading frame 64 C9orf64 S.2O8914 223697 X at chromosome 9 open reading frame 64 C9orf64 S.2O8914 235940 at chromosome 9 open reading frame 68 C9orf68 S.1796.15 1554,707 at chromosome 9 open reading frame 7 C9Crf7 S.62OO3 61874 at chromosome 9 open reading frame 80 C9Crf30 S.4948.54 223559 s at chromosome 9 open reading frame 9 C9Crf S.62595 220050 at chromosome 9 open reading frame 95 C9CrfS S.494-186 219147 s at chromosome 9 open reading frame 97 fif C9Crf7 S.494-595 213161 at chromosome 9 open reading frame 97 Chromosome 9 open reading frame 98 C9Crf8 S.421340 1557666 S. at chromosome condensation 1 CHC1 S.469723 215747 s at chromosome condensation-related SMC- CNAP1 S.S719 201774 S at associated protein 1 Chromosome X open reading frame 15 CXorf15 S.534464 1557954 at chromosome X open reading frame 33 CXorf33 S.512181 235433 at Chromosome X open reading frame 40 CXorf240 S.4253.83 228809 at chromosome X open reading frame 40 CXorf240 S.S49718 214112 s at hypothetical LOC541578 protein LOCS41578 chromosome X open reading frame 44 similar to CXorf244 S.415414 227869 at LOC90736 protein LOC440474 cisplatin resistance-associated overexpressed CROP S.130293 208835 S. at protein clathrin, heavy polypeptide (HC) CLTC S.491351 200614 at Clathrin, heavy polypeptide (He) CLTC S.491351 238646 at clathrin, light polypeptide (Lca) CLTA S.522114 200960 x at clathrin, light polypeptide (Lca) CLTA S.522114 216295 S at claudin 1 CLDN1 S.43906O 222549 at Claudin 1 CLDN1 S.43906O 238967 at claudin 10 CLDN10 S.S34377 205328 at cleavage and polyadenylation specific factor 2, CPSF2 S.435675 225986 X at 100 kDa US 2006/01992.04 A1 Sep. 7, 2006 23

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Cleavage and polyadenylation specific factor 6, CPSF6 S.369606 238913 a 68 kDa cleavage stimulation factor, 3' pre-RNA, subunit 3, CSTF3 S.444.02 203947 a 77 kDa cleavage stimulation factor, 3' pre-RNA, subunit 3, CSTF3 S.444.02 229666 s at 77 kDa clock homolog (mouse) CLOCK S.436975 204980 a Clone 114 tumor rejection antigen mRNA, S.S47549 226886 a complete cols one 23641 mRNA sequence S.S35382 214148 a one 23728 mRNA sequence S.467866 213567 a one 23948 mRNA sequence S.159264 215304 a one 24487 mRNA sequence S.2838.19 215825 a. one A9A2BRB5 (CAC)n (GTG)n repeat S.524171 211994 a containing mRNA. If Clone A9A2BRB5 (CAC)n (GTG)n repeat-containing mRNA. Clone DT1P1A11 mRNA, CAG repeat region S.98834 222072 a Clone FLB2932 mRNA sequence S.2744.05 233037 a Clone IMAGE: 111714 mRNA sequence S.15671 2284.66 a ClpX caseinolytic protease X homolog (E. coli) CLPX S.113823 204809 a clusterin (complement lysis inhibitor, SP-40, 40, CLU S.436657 208792 s a Sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) Clusterin (complement lysis inhibitor, SP-40, 40, CLU S.436657 231499 s a Sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) clusterin associated protein 1 CLUAP1 S.155995 204576 s a c-Maf-inducing protein CMIP S.461510 224992 S a c-Mplbinding protein LOC113251 S.266.13 212714 at c-myc binding protein MYCBP S.370040 203360 s a coactivator-associated arginine methyltransferase1 CARM1 S.371416 212512 s a coagulation factor VIII, procoagulant component S.413O83 205756 S a (hemophilia A) coagulation factor XIII, A1 polypeptide F13A1 S.33SS13 203305 a coatomer protein complex, Subunit beta COPB S.339278 201358 s a Coatomer protein complex, Subunit beta COPB S.339278 233308 a COBW domain containing 1 CBWD1 S.S31330 226193 x a cofactor required for Sp1 transcriptional activation, CRSP7 S.466117 227538 a subunit 7, 70 kDa cofilin 1 (non-muscle) if cofilin 1 (non-muscle) CFL1 S.17O622 200021 a coiled-coil domain containing 13 CCDC13 S.191036 1553397 at coiled-coil domain containing 15 CCDC15 S.512748 220466 a coiled-coil domain containing 16 CCDC16 S.413678 226315 a. coiled-coil domain containing 7 CCDC7 S.436242 1553214 a at coiled-coil domain containing 7 CCDC7 S.436242 1553215 s at coilin COIL S.S32795 203654 S a cold shock domain protein A CSDA S.221889 201160 s a collaborates, cooperates with ARF (alternate CARF S.32922 218929 a reading frame) protein collagen, type I, alpha 2 COL1A2 S.489142 2024.03 s a collagen, type II, alpha 1 (primary osteoarthritis, COL2A1 S.408182 213492 a spondyloepiphyseal dysplasia, congenital) collagen, type III, alpha 1 (Ehlers-Danlos syndrome S.443625 201852 x a type IV, autosomal dominant) collagen, type III, alpha 1 (Ehlers-Danlos syndrome S.443625 215076 s a type IV, autosomal dominant) collagen, type IV, alpha 3 (Goodpasture antigen) S.27.0437 223466 x a binding protein Collagen, type IV, alpha 3 (Goodpasture antigen) S.27.0437 238,279 x a binding protein collagen, type IX, alpha 1 S.1498.09 1555527 at collagen, type XI, alpha 2 S.3901.71 216993 s a collagen, type XXV, alpha 1 if collagen, type XXV, COL25A1 S.112925 224388 s a alpha 1 collagen, type XXV, alpha 1 if collagen, type XXV, COL25A1 S.112925 224389 s a alpha 1 collagen, type XXVII, alpha 1 S.494.892 225293 at colony stimulating factor 2 receptor, beta, low S.2854(O1 205159 at affinity (granulocyte-macrophage) i? colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) US 2006/01992.04 A1 Sep. 7, 2006 24

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID COMM domain containing 3 COMMD3 218048 at complement component 1, q. Subcomponent C1OBP 214214 S a binding protein complement component 4A complement S.534847 214428 X a component 4B i? complement component 4B, telomeric component of oligomeric golgi complex 2 COG2 S.211800 203073 at component of oligomeric golgi complex 5 COGS S.239631 203630 s a congenital dyserythropoietic anemia, type I CDAN1 S.4378.19 228516 at conserved helix-loop-helix ubiquitous kinase CHUK S.198.998 209666 s a COP9 constitutive photomorphogenic homolog COPS5 S.491912 201652 at subunit 5 (Arabidopsis) COP9 constitutive photomorphogenic homolog COPS6 S.15591 201405 s a subunit 6 (Arabidopsis) copine III CPNE3 S.1912.19 202118 s a copine VIII CPNE8 S.4O910 243727 at core 1 synthase, glycoprotein-N- C1GALT1 S.239666 219439 at acetylgalactosamine 3-beta-galactosyltransferase, 1 core-binding factor, beta subunit S.460988 202370 s a core-binding factor, runt domain, alpha Subunit 2: S.153934 238,549 at translocated to, 2 cornichon homolog (Drosophila) CNIH 201653 at coronin 6 CORO6 1552301 a. at coronin, actin binding protein, 1C CORO1C 221676 s a COX11 homolog, cytochrome c oxidase assembly COX11 203551 S a protein (yeast) COX11 homolog, cytochrome c oxidase assembly COX11 211727 s a protein (yeast) / COX11 homolog, cytochrome c oxidase assembly protein (yeast) COX15 homolog, cytochrome c oxidase assembly COX15 S.28326 219547 at protein (yeast) COX15 homolog, cytochrome c oxidase assembly COX15 S.28326 235204 at protein (yeast) coxsackie virus and adenovirus receptor CXADR S.473417 203917 at CPX chromosome region, candidate 1 CPXCR1 S.458292 1560493 a at creatine kinase, brain CKB S.173724 2008.84 at Crm, cramped-like (Drosophila) CRAMP1L, 225172 at crystallin, mu CRYM HS.924 205489 at crystallin, Zeta (quinone reductase)-like 1 CRYZL.1 S.352671 1552347 at CSE1 chromosome segregation 1-like (yeast) CS S.90O73 201111 at CSE1 chromosome segregation 1-like (yeast) CS S.90O73 201112 s at CSE1 chromosome segregation 1-like (yeast) CS S.90O73 210766 s at CTAGE family, member 5 CTAGES S.SO92OO 204055 s at CTD (carboxy-terminal domain, RNA polymerase CT DSP2 S.S24530 203445 s at II, polypeptide A) Small phosphatase 2 CTD (carboxy-terminal domain, RNA polymerase CT DSP2 S.S24530 208735 S. at II, polypeptide A) Small phosphatase 2 C-terminal binding protein 1 CT S.2O8597 203392 s at C-terminal binding protein 1 CT S.2O8597 212863 x at C-terminal binding protein 2 CT S.SO1345 201220 x at C-terminal binding protein 2 CT S.SO1345 210835 S. at C-terminal binding protein 2 || | LOC440008 CT S.SO1345 201219 at

LOC44OOO8 C-terminal modulator protein CTMP S.164O70 229253 at CTL2 protein CT S.515134 224609 at CTP synthase CT S473O87 202613 at C-type lectin domain family 4, member A CL S.SO4657 219947 at C-type lectin domain family 7, member A / C-type CL S.143929 221 698 s at lectin domain family 7, member A CUB and Sushi multiple domains 2 CSMD2 S.127736 242933 at CUG triplet repeat, RNA binding protein 1 CUGBP1 S.5.30727 2094.89 at CUG triplet repeat, RNA binding protein 2 CUGBP2 S.309.288 1560049 at CUG triplet repeat, RNA binding protein 2 CUGBP2 S.309.288 202157 s at CUG triplet repeat, RNA binding protein 2 CUGBP2 S.309.288 2271 78 at cullin 1 CUL1 S.146806 207614 S at cullin 2 CUL2 S.82919 203079 S at cullin 3 CUL3 S.372.286 201370 s at cullin 3 CUL3 S.372.286 201371 s at Cullin 3 CUL3 S.372.286 242362 at cullin 4B CUL4B S.102914 210257 X at US 2006/01992.04 A1 Sep. 7, 2006 25

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Cullin 5 CUL5 S.44032O 203531 at cutaneous T-cell lymphoma-associated antigen 1 CTAGE1 S.406709 220957 at cut-like 1, CCAAT displacement protein CUTL1 S.438.974 214743 at (Drosophila) CXXC finger 1 (PHD domain) CXXC1 S.180933 48580 at CXXC finger 5 CXXC5 S.1891.19 222996 s at CXXC finger 5 CXXC5 S.1891.19 23395S X at CXXC finger 5 // CXXC finger 5 CXXC5 S.1891.19 224.516 s at CXYorf1-related protein FLJ25222 S.459573 236841 at cyclic AMP phosphoprotein, 19 kD ARPP S.512908 214553 s at 19 cyclic AMP phosphoprotein, 19 kD ARPP S.512908 221482 s at 19 cyclic AMP phosphoprotein, 19 kD ARPP S.512908 221483 s at 19 cyclic AMP-regulated phosphoprotein, 21 kD ARPP 231935 a. 21 cyclin A1 CCNA1 S.417 OSO 205899 a Cyclin A2 CCNA2 S.851.37 213226 a cyclin B1 interacting protein 1 CCNB1|P1 S.107003 217988 a cyclin B2 CCNB2 S.194698 202705 a cyclin E2 CCNE2 S.408658 205034 a cyclin E2 CCNE2 S.408658 211814 S at cyclin G associated kinase GAK S.3696O7 202281 a cyclin G associated kinase GAK S.3696O7 40225 at cyclin H CCNH S.1466O7 204093 a Cyclin H CCNH S.1466O7 238243 a Cyclin J CCNJ S.281348 1557830 at cyclin M1 CNNM1 S.274579 22O166 a cyclin M3 CNNM3 S.150895 220739 s at Cyclin M3 CNNM3 S.150895 229031 a Cyclin-dependent kinase 8 CDK8 S.382306 204831 a Cyclin-dependent kinase inhibitor 1C (p57, Kip2) CDKN1C S.106O70 213348 a cyclin-dependent kinase inhibitor 3 (CDK2 CDKN3 S.841.13 209714 S at associated dual specificity phosphatase) Cyclin-dependent kinase-like 1 (CDC2-related CDKL1 241928 a kinase) cylicin, basic protein of sperm head cytoskeleton 1 CYLC1 S.444230 216778. S. at cylicin, basic protein of sperm head cytoskeleton 1 CYLC1 S.444230 216809 a cylicin, basic protein of sperm head cytoskeleton 2 CYLC2 S.3232 2O7780 a cystathionase (cystathionine gamma-lyase) CTH S.19904 217127 a cystathionine-beta-synthase CBS S.S33013 1553972 a. at cystatin pseudogene LOC16438O S.4OOOO7 1558493 at cysteine and glycine-rich protein 2 CSRP2 S.530904 207030 S at cysteine and histidine-rich domain (CHORD)- CHORDC1 S.22857 218566 s at containing, Zinc binding protein 1 cysteine-rich hydrophobic domain 2 CHIC2 S.33S393 219492 a cysteine-rich secretory protein 1 CRISP1 S.10962O 207032 S at cysteine-rich secretory protein 1 CRISP1 S.10962O 216314 a cysteine-rich secretory protein 2 CRISP2 S.2042 210262 a cysteine-rich, angiogenic inducer, 61 CYR61 S.8867 201289 a cysteinyl-tRNA synthetase CARS S.274873 212971 a cystinosis, nephropathic CTNS S.1876.67 36566 at cytidine and dcMP deaminase domain containing 1 CDADC1 S.38822O 223527 s a cytidine and dcMP deaminase domain containing 1 CDADC1 S.38822O 233647 s a cytochrome b, ascorbate dependent 3 CYBASC3 S.22546 224735 a. cytochrome b-5 CYB5 S.465413 207843 x a cytochrome b-5 CYB5 S.465413 209366 x a cytochrome b5 reductase b5R.2 CYB5R2 S.414362 220230 s a cytochrome c oxidase subunit 8C COX8C S.128935 231487 a cytochrome c oxidase subunit IV isoform 1 COX41 S.433419 202698 x a cytochrome c oxidase subunit IV isoform 1 COX41 S.433419 213758 a cytochrome c oxidase subunit IV isoform 1 if COX41 S.433419 20008.6 s a cytochrome c oxidase subunit IV isoform 1 cytochrome c oxidase subunit Vb COXSB S.1342 202343 x a cytochrome c oxidase subunit Vb COXSB S.1342 21373.5 S a cytochrome c oxidase subunit VIc COX6C S.351875 201754 at cytochrome c oxidase subunit VIIa polypeptide 2 COX7A2 S.70312 201597 at (liver) cytochrome c oxidase subunit VIIc COX7C S.430075 217491 x a cytochrome c, somatic CYCS S.437O60 208905 at US 2006/01992.04 A1 Sep. 7, 2006 26

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID cytochrome P450, fami y 1, Subfamily A, HS.1361 2O7608 X at polypeptide 2 cytochrome P450, fami y 1, subfamily B, HS.154654 202435 S. at polypeptide cytochrome P450, fami y 1, subfamily B, HS.154654 202436 s at polypeptide cytochrome P450, fami y 2, Subfamily A, 207718 X at polypeptide 6 cytochrome P450, family 2, Subfamily A, polypepti e 7 // cytochrome P450, amily 2, Subfamily A, polypeptide 7 pseudogene 1 fit cytoc hrome P450, family 2, Subfamily A, polypeptide 13 cytochrome P450, fami y 2, subfamily C, S.282871 208147 s at polypeptide 8 cytochrome P450, family 2, Subfamily C, polypepti e 8 cytochrome P450, fami y 2, subfamily C, S.282624 214421 X at polypeptide 9 ochrome P450, fami y 2, subfamily R, S.371427 227109 at polyp OC o l P450, fami y 2, subfamily U, S.109087 226393 at poly O l ily 4, Subfamily V. S.237642 226745 at polype OC l ily 51, Subfamily A, S.417.077 216607 s at ypepti okine induced apop osis inhibitor 1 S.4900 208968 s at cytokine receptor-like actor 3 S.3701.68 205474 a O kine-like nuclear factor n-pac S.3872SS 218506 x at O plasmic FMR1 interacting protein 1 S.26704 208923 a O plasmic linker associated protein 1 S.46984O 212752 a cytoplasmic polyadeny ation element binding S.546423 222903 s at protein 1 cytoplasmic polyadeny ation element binding S.374216 226939 a protein 2 cytoplasmic polyadeny ation element binding S.374216 235479 a protein 2 cytoplasmic polyadeny ation element binding CPEB3 S.131683 1555.250 a. at protein 3 cytoplasmic polyadeny ation element binding CPEB4 S.127126 224829 a protein 4 cytoskeleton-associate protein 4 CKAP4 S.74368 200999 S at DALR anticodon binding domain containing 3 DALRD3 S.280978 2188.08 a DAZ associated protein 2 i? similar to DAZ DAZAP2 S.369761 214334 x at associated protein 2 (Deleted in azoospermia associated protein 2) LOC4O1029 DAZ interacting protein 1 DZIP1 S.1570O2 204556 S at DC13 protein DC13 S3882SS 218447 a DC2 protein DC2 S.445803 223.001 a DCP1 decapping enzyme homolog B (S. cerevisiae) DCP1B S.130934 226093 a DCP2 decapping enzyme homolog (S. cerevisiae) DCP2 S.443875 244777 a DHD domain containing DHD1 S.513260 225965 a DHD domain containing DHD1 S.513260 231165 a. DHD domain containing DHD1 S.513260 244154 a DHD domain containing 2 DHD2 S.434966 212690 a EAD (Asp-Glu-Ala-Asp) box polypeptide 10 DX10 S.S2S115 204977 a EAD (Asp-Glu-Ala-Asp) box polypeptide 17 DX17 S.S283OS 208718 a EAD (Asp-Glu-Ala-Asp) box polypeptide 18 DX18 S.3634.92 208895 S at EAD (Asp-Glu-Ala-Asp) box polypeptide 20 DX20 S.4858.10 223331 s at EAD (Asp-Glu-Ala-Asp) box polypeptide 21 fff DX21 S.223141 208152 s at EAD (Asp-Glu-Ala-Asp) box polypeptide 21 EAD (Asp-Glu-Ala-Asp) box polypeptide 21 fff DX21 S.223141 224654 at Zinc finger protein 596 NF596 EAD (Asp-Glu-Ala-Asp) box polypeptide 24 DX24 S.S10328 200694 S at EAD (Asp-Glu-Ala-Asp) box polypeptide 25 DX25 S.42O263 219945 at EAD (Asp-Glu-Ala-Asp) box polypeptide 27 DX27 S.65234 215693 x at EAD (Asp-Glu-Ala-Asp) box polypeptide 3, X DX3X S.380774 201210 at inked DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X D S.380774 2O7617 at inked US 2006/01992.04 A1 Sep. 7, 2006 27

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X S.380774 212514 x at inked DEAD (Asp-Glu-Ala-Asp) box po peptide 3, Y D S.9912O 205001 s at inked EAD (Asp-Glu-Ala-Asp) box po e DX31 S.49S410 1553181 at EAD (Asp-Glu-Ala-Asp) box po e DX4 S.223581 221 630 s at EAD (Asp-Glu-Ala-Asp) box po e DX42 HS.876S 201788 a EAD (Asp-Glu-Ala-Asp) box po e DX48 S.389649 201303 a EAD (Asp-Glu-Ala-Asp) box po e DX5 S.279806 243206 a EAD (Asp-Glu-Ala-Asp) box po e DX5 S.279806 200033 a EAD (Asp-Glu-Ala-Asp) box po e EAD (Asp-Glu-Ala-Asp) box po e DX50 S.522984 1568815 a. at EAD (Asp-Glu-Ala-Asp) box po e DX52 S.408452 210320 s at EAD (Asp-Glu-Ala-Asp) box po e DX52 S.408452 212834 a EAD (Asp-Glu-Ala-Asp) box po e DX58 S.190622 242961 x at EAD (Asp-Glu-Ala-Asp) box po e DX6 S.408461 225549 a ad end homolog 1 (zebrafish) ND1 S.SS2623 222070 a ad end homolog 1 (zebrafish) ND1 S.SS2623 57739 at EAD/H (Asp-Glu-Ala-Asp (His) box polypeptide 26 DX26 S.4394.40 218819 a EAD/H (Asp-Glu-Ala-Asp (His) box polypeptide 26 DX26 S.4394.40 222239 s at EAD/H (Asp-Glu-Ala-Asp (His) box polypeptide 26 DX26 S.4394.40 235283 a EAH (Asp-Glu-Ala-Asp (His) box polypeptide 57 HX57 S.468,226 239311 a EAH (Asp-Glu-Ala-His) box polypeptide 16 HX16 S.485060 203694 S at EAH (Asp-Glu-Ala-His) box polypeptide 29 HX29 S.444208 212648 a EAH (Asp-Glu-Ala-His) box polypeptide 30 HX30 S.S17948 1556144 at EAH (Asp-Glu-Ala-His) box polypeptide 30 HX30 S.S17948 230871 a EAH (Asp-Glu-Ala-His) box polypeptide 32 HX32 S.SO1379 218198 a EAH (Asp-Glu-Ala-His) box polypeptide 33 HX33 S.250456 222875 a. EAH (Asp-Glu-Ala-His) box polypeptide 36 HX36 S.446270 223138 s at EAH (Asp-Glu-Ala-His) box polypeptide 36 HX36 S.446270 223139 s at EAH (Asp-Glu-Ala-His) box polypeptide 40 HX40 S.29403 222574 S at EAH (Asp-Glu-Ala-His) box polypeptide 8 HX8 S.4631 OS 227079 a EAH (Asp-Glu-Ala-His) box polypeptide 9 S.1915.18 202420 S at EAH (Asp-Glu-Ala-His) box polypeptide 9 S.1915.18 212107 s at EAH (Asp-Glu-Ala-His) box polypeptide 9 S.1915.18 215467 x at eath associated transcription factor 1 DATF1 S.551527 213213 a eath-associated protein kinase 1 DAPK1 S.380277 2031.39 a ecay accelerating factor for complement (CD55, DAF S.S27653 201926 s at Cromer blood group system) edicator of cytokinesis 5 DOCKS S.195403 1569590 at efender against cell death 1 defender against DAD1 S.82890 200046 a cell death efensin, beta 106A DEFB106A S.S11958 1552411 at ehydrodolichyl diphosphate synthase DHDDS S.36938S 218547 a ehydrogenase/reductase (SDR family) member 2 DHRS2 S.2724.99 214079 a ehydrogenase/reductase (SDR family) member 9 DHRS9 S.1796.08 219799 S a Deleted in lymphocytic leukemia, 2 DLEU2 S.508041 1556820 a. at eleted in lymphocytic leukemia, 2 fit BCMS DLEU2 S.508041 215629 s a upstream neighbor-like BCMSUNL eleted in lymphocytic leukemia, 2 fit BCMS DLEU2 S.508041 216870 x a upstream neighbor-like BCMSUNL eleted in malignant brain tumors 1 DMBT1 S.2796.11 O8250 s a Dendritic cell protein GA17 S.5O2244 5190 at Dendritic cell-derived ubiquitin-like protein DC-UbP S.179852 24827 at DEP domain containing 1 DEPDC1 S.445098 20295 x a DEP domain containing 6 DEPDC6 S.3O3788 8858 at Derl-like domain family, member 3 DERL3 S.159971 28897 at desmuslin DMN S.207106 2730 at destrin-2 pseudogene LOC171220 211325 X a development and differentiation enhancing factor 1 DDEF1 S.106O15 224790 at development and differentiation enhancing factor 1 DDEF1 S.106O15 224791 at development and differentiation enhancing factor 1 DDEF1 S.106O15 224796 at development and differentiation enhancing factor 1 DDEF1 S.106O15 2365.33 at development and differentiation enhancing factor 2 DDEF2 S.467662 206414 S at diablo homolog (Drosophila) DIABLO S.1696.11 219350 s at diacylglycerol O-acyltransferase homolog 2 DGAT2 S.334305 226064 S at (mouse) Diaphanous homolog 1 (Drosophila) DIAPH1 S.5294-51 1560080 at diaphanous homolog 2 (Drosophila) DIAPH2 S.226483 205603 s at US 2006/01992.04 A1 Sep. 7, 2006 28

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Dicer1, Dcr-1 homolog (Drosophila) DICER1 S.87889 213229 at dickkopf homolog 1 (Xenopus laevis) DKK1 S.40499 204602 at dickkopf homolog 3 (Xenopus laevis) DKK3 S.2921.56 214247 s a DiGeorge syndrome critical region gene 5 (non DGCRS S.SS1533 215244 at coding) DiGeorge syndrome critical region gene 6 DGCR6 S.410965 208024 S a DiGeorge syndrome critical region gene 6-like DGCR6L ihydrofolate reductase DHFR S.83765 202534 x a ihydrolipoamide branched chain transacylase E2 DBT S.270570 205370 x a ihydropyrimidinase-like 5 DPYSL5 S.299.315 224100 s a ipeptidylpeptidase 8 DPP8 S.458.609 220939 s a isabled homolog 2, mitogen-responsive DAB2 S.48198O 201280 s a phosphoprotein (Drosophila) iscoidin domain receptor family, member 1 DDR1 210749 x a Discoidin domain receptor family, member 2 DDR2 227561 a iscs, large (Drosophila) homolog-associated DLGAP4 233056 X a protein 4 iscs, large homolog 1 (Drosophila) S.292549 202515 a. iscs, large homolog 5 (Drosophila) S.SOO245 201681 s a Dishevelled associated activator of morphogenesis 1 S.19156 1555989 at Dishevelled associated activator of morphogenesis 1 S.19156 226666 a Dishevelled associated activator of morphogenesis 1 S.19156 244O62 a J39G22.2 (novel protein) S.406265 231264 a DKFZp434AO131 protein S.535037 221191 a DKFZp434AO131 protein S.SSO749 229949 a DKFZP434B0335 protein S.S11979 227580 S at DKFZP434B0335 protein S.S11979 227581 a DKFZP434B061 protein S.448.583 233092 s at DKFZP434H132 protein S.17936 215087 a DKFZP564B167 protein S.S17768 202427 s at DKFZP564C152 protein S.184216 216028 a DKFZP564C196 protein S.127384 222384 a DKFZP564G2022 protein S.51.1138 212202 s at DKFZP586 AO522 protein S.288771 2097.03 X at Dmx-like 1 S.181042 241472 a DNA (cytosine-5-)- 3 beta S.251673 220668 s at DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) S.524156 2196.78 x at DNA damage repair and recombination protein S.179697 215312 a RAD52 pseudogene DNA polymerase-transactivated protein 6 DNAPTP6 S.12O323 241812 a DNA polymerase-transactivated protein 6 DNAPTP6 S.12O323 244597 a DNA segment on (unique) 234 D4S234E S.S18595 209569 x a expressed sequence DNA-damage inducible protein DDI1 239299 a DnaJ (Hsp40) homolog, subfamily A, member 1 DNAJA1 S.4452O3 200880 a DnaJ (Hsp40) homolog, subfamily A, member 1 DNAJA1 S.4452O3 200881 s a DnaJ (Hsp40) homolog, subfamily A, member 2 DNAJA2 S.368078 226994 a DnaJ (Hsp40) homolog, subfamily A, member 3 DNAJA3 S.459.779 1554078 s at DnaJ (Hsp40) homolog, subfamily A, member 3 DNAJA3 S.459.779 205963 s a DnaJ (Hsp40) homolog, subfamily A, member 4 DNAJA4 S.S13053 1554334 a at DnaJ (Hsp40) homolog, subfamily B, member 1 DNATB1 S.S15210 200666 s a DnaJ (Hsp40) homolog, subfamily B, member 4 DNAB4 S.380282 203811 s a DnaJ (Hsp40) homolog, subfamily B, member 6 DNATB6 S.490745 208810 at DnaJ (Hsp40) homolog, subfamily B, member 6 DNATB6 S.490745 20881.1 s a DnaJ (Hsp40) homolog, subfamily B, member 6 DNATB6 S.490745 209015 s a DnaJ (Hsp40) homolog, subfamily B, member 8 DNAB8 S.518241 237284 at DnaJ (Hsp40) homolog, subfamily B, member 9 DNATB9 HS.6790 202842 s a DnaJ (Hsp40) homolog, subfamily C, member 1 DNAJC1 S.499OOO 222620 S a DnaJ (Hsp40) homolog, subfamily C, member 1 DNAJC1 S.499OOO 222621 at DnaJ (Hsp40) homolog, subfamily C, member 1 DNAJC1 S.499OOO 242216 at DnaJ (Hsp40) homolog, subfamily C, member 12 DNAJC12 S.26O72O 223722 at DnaJ (Hsp40) homolog, subfamily C, member 4 DNAJC4 S.172847 213919 at DnaJ (Hsp40) homolog, subfamily C, member 9 DNAJC9 S.S23O37 21308.8 s at DnaJ homology subfamily A member 5 DNAJAS S.131887 238337 S at docking protein 5 DOKS S4731.33 21484.4 S at dolichyl-diphosphooligosaccharide-protein DDOST S.S231.45 208.674 x at glycosyltransferase dolichyl-phosphate (UDP-N-acetylglucosamine) N DPAGT1 S.S24081 209509 S at acetylglucosaminephosphotransferase 1 (GlcNAc 1-P transferase) US 2006/01992.04 A1 Sep. 7, 2006 29

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID dolichyl-phosphate mannosyltransferase DPM1 S.54908O 202673 at polypeptide 1, catalytic Subunit Dolichyl-phosphate mannosyltransferase DPM1 S.54908O 237213 at polypeptide 1, catalytic Subunit dom-3 homolog Z (C. elegans) DOM3Z S.153299 38157 at dopachrome tautomerase (dopachrome delta DCT S.3O1865 205338 s at , tyrosine-related protein 2) dopamine receptor D5 DRDS S.380681 208486 a doublecortin and CaM kinase-like 1 DCAMKL1 S.507755 205399 a Down syndrome critical region gene 1 DSCR1 S.282326 208370 s at Down syndrome critical region gene 2 DSCR2 S473838 203405 a Down syndrome critical region gene 3 DSCR3 S.369488 233.108 a Down syndrome critical region gene 8 DSCR8 S.1923.71 241224 X at down-regulated by Ctnnb1, a DRCTNNB1A S.856O3 231396 s at downregulated in ovarian cancer 1 DOC1 S.104672 1554965 at downregulated in ovarian cancer 1 DOC1 S.104672 204135 a. down-regulator of transcription 1, TBP-binding DR1 S.348418 209188 x at (negative cofactor 2) DPH2-like 1 (S. cerevisiae) i? candidate tumor S.S13856 222041 a Suppressor in ovarian cancer 2 fD. WCA2 DRE1 protein RE1 206551 X at DRE1 protein E1 221985 a ual adaptor of phosphotyrosine and 3 PP1 219290 x at phosphoinositides ual specificity phosphatase 1 USP1 S.171695 201041 s at ual specificity phosphatase 10 USP10 S.497822 215501 s at ual specificity phosphatase 10 USP10 S.497822 221563 a ual specificity phosphatase 19 USP19 S.132237 1555598 a. at ual specificity phosphatase 21 USP21 S.534478 220515 a. Dual specificity phosphatase 22 USP22 S.29106 226440 a ual specificity phosphatase 6 USP6 S.298654 208892 s at UTP pyrophosphatase UT S.S2798O 20895S a UTP pyrophosphatase UT S.S2798O 208956 X at UTP pyrophosphatase UT S.S2798O 209932 S at ymeclin YM S.162996 223171 a Dynamin 1-like if CGI-04 protein DNM1L, S.SOS231 if 226154 a fif CGIO)4 S.SSO499 ynamin 3 DNM3 S.494751 209839 a Dynein light chain 2 Dlc2 S.514368 225494 a ynein light chain 2 Dlc2 S.514368 229106 a ynein, axonemal, heavy polypeptide 7 DNAH7 S.974O3 214222 a ynein, axonemal, heavy polypeptide 7 DNAH7 S.974O3 234476 a ynein, axonemal, intermediate polypeptide 1 DNAI1 S.112667 233195 a ynein, cytoplasmic, intermediate polypeptide 1 DNCI1 S.440364 20534.8 s a ynein, cytoplasmic, intermediate polypeptide 2 DNCI2 S.5462SO 211684 S a ynein, cytoplasmic, intermediate polypeptide 2 ynein, cytoplasmic, light intermediate polypeptide 2 DNCLI2 S.369068 2246.16 a ynein, cytoplasmic, light polypeptide 1 DNCL1 S.512O 200703 a ynein, cytoplasmic, light polypeptide 2A DNCL2A S.S31876 217917 s a ynein, cytoplasmic, light polypeptide 2A DNCL2A S.S31876 217918 a Dystonin DST S.485 616 215810 x a yStrobrevin, alpha DTNA S.58919 205741 s a Dystrobrevin, alpha S.58919 24.0125 a. E1A binding protein p300 S.517517 202221 S a E2a-Pbx1-associated protein S.SO6458 227439 a E2F transcription factor 2 S.194333 228,361 a E3 identified by differential display S.4924.45 208882 s a E3 identified by differential display S.4924.45 232264 a E74-like factor 2 (ets domain transcription factor) S.260903 203822 s a Early B-cell factor S.3O8048 227646 a Early endosome antigen 1, 162 kD EA1 S.S.06309 1564798 at early growth response 1 GR1 S.326O3S 201694 S a Early growth response 1 GR1 S.326O3S 2274.04 S a early growth response 3 S.534313 206115 a. EBNA1 binding protein 2 BNA1BP2 S.346868 201323 a echinoderm microtubule associated protein like 2 ML2 S.241.78 204398 s a Echinoderm microtubule associated protein like 5 MLS S.549263 242443 a ecotropic viral integration site 1 VI1 S.165830 226420 a ectodysplasin A receptor DAR S.171971 220048 a ectonucleoside triphosphate diphosphohydrolase 1 E NT P D 1 S.SSO467 209473 a US 2006/01992.04 A1 Sep. 7, 2006 30

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID ectonucleoside triphosphate diphosphohydrolase 4 ENTPD4 S.444389 204077 X at ectonucleotide ENPP2 S190977 209392 a pyrophosphatase/phosphodiesterase 2 (autotaxin) EF hand domain family, member D2 EFEHD2 S.465374 222483 a -hand domain (C-terminal) containing 1 EFEHC1 S.403171 225656 a -hand domain (C-terminal) containing 2 EFEHC2 S.S21953 220591 s at domain binding protein 1 EHBP1 S.271667 212650 a H-domain containing 1 EHD1 S.S23774 209037 S at LAV (embryonic lethal, abnormal vision, ELAVL2 S.166109 228260 a rosophila)-like 2 (Huantigen B) LAV (embryonic lethal, abnormal vision, ELAVL3 S.1701 227612 a rosophila)-like 3 (Huantigen C) LAV (embryonic lethal, abnormal vision, ELAVL4 S.213 OSO 206051 a rosophila)-like 4 (Huantigen D) LAV (embryonic lethal, abnormal vision, ELAVL4 S.213 OSO 241424 a rosophila)-like 4 (Huantigen D) LG protein HSA277841 S.120963 218896 s at S.128434 215287 a S.128434 244354 a L associated factor 1 EA. F 1 S.474479 226952 a

MO domain containing 2 LMOD2 S.4501(OS 226502 a ELMO domain containing 2 LMOD2 S.4501(OS 233912 x at elongation factor RNA polymerase II-like 3 LL3 S.171466 219518 S at elongation factor Tu GTP binding domain FTUD1 S.459114 218973 a containing 1 elongation factor, RNA polymerase II, 2 LL2 S.192221 226099 a ongation factor, RNA polymerase II, 2 LL2 S.192221 240038 a LOVL family member 5, elongation of long chain LOVL5 S.S2O189 1566079 at y acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LOVL family member 5, elongation of long chain E LOVL5 214153 a y acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LOVL family member 5, elongation of long chain E LOVL5 215082 a y acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LYS transcription factor-like protein TMBS62 LYS S.30O887 226115 a. endo-beta-N-acetylglucosaminidase 21865 S.29288 65635 at Endothelial PAS domain protein 1 PAS1 S.468410 242868 a endothelin receptor type B DNRB S.82002 204271 s a Enhancer of polycomb homolog 1 (Drosophila) PC S.1678OS 216437 a enhancer of polycomb homolog 1 (Drosophila) PC S.1678OS 225417 a enhancer of polycomb homolog 1 (Drosophila) PC S.1678OS 234969 s a Enhancer of Zeste homolog 2 (Drosophila) ZH 2 S.444082 215006 a enolase 1, (alpha) S.S17145 201231 s a enoyl Coenzyme A hydratase domain containing 1 S.4864-10 233124 S a Enoyl Coenzyme A hydratase domain containing 1 S.4864-10 243303 a EPH receptor A10 S.129435 243717 a EPH receptor A5 S.479853 1557697 at EPH receptor A5 S.479853 215664 S a epidermal growth factor receptor (erythroblastic S.488293 211551 a eukemia viral (v-erb-b) oncogene homolog, avian) epidermal growth factor receptor pathway E C S 5 S.83722 217887 s a Substrate 15 epidermal growth factor receptor pathway E 222113 s a Substrate 15-like 1 epididymal sperm binding protein 1 LSPBP1 S.104894 220366 a epithelial protein lost in neoplasm beta PLIN S.525419 217892 s a Epithelial stromal interaction 1 (breast) PSTI1 S.546467 1556297 a. at epithelial stromal interaction 1 (breast) PSTI1 S.546467 227609 a EPM2A (laforin) interacting protein 1 PM2AIP1 S.28O2O 202909 a EPM2A (laforin) interacting protein 1 PM2AIP1 S.28O2O 227847 a Era G-protein-like 1 (E. coli) RAL.1 S.3426 212087 s at ERO1-like (S. cerevisiae) RO1L, S.S2S339 222646 s at Erythrocyte membrane protein band 4.1-like 2 PB41L2 S.486470 242652 a erythrocyte membrane protein band 4.1-like 3 PB41L3 S.213394 212681 a erythrocyte membrane protein band 4.1-like 3 if PB41L3 S.213394 211776 s at erythrocyte membrane protein band 4.1-like 3 esophageal cancer related gene 4 protein ECRG4 S.431.25 223623 a Espin ESPN S.147953 242327 x at essential meiotic endonuclease 1 homolog 1 (S. pombe) EME1 S.51433O 234465 a. esterase D formylglutathione hydrolase ESD S.432491 215096 s at estrogen receptor binding protein ERBP S.85769 202776 a estrogen receptor associated, antigen, 9 EBAG9 S.4O9368 204278 s at US 2006/01992.04 A1 Sep. 7, 2006 31

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID estrogen-related receptor beta like 1 ESRRBL1 HS.4121.96 218100 s at ethanolamine kinase 1 ETNK1 HS.24.0056 219017 at ethanolamine kinase 2 ETNK2 HS.497469 219268 at etoposide induced 2.4 mRNA EI24 HS.343911 216396 s at ets variant gene 1 ETV1 HS.22634 206501 x at ets variant gene 6 (TEL oncogene) ETV6 HSSO476S 225764 at euchromatic histone methyltransferase 1 EHMT1 HS.49SS11 225461 at eukaryotic elongation factor-2 kinase EEF2K HS.S49151 225545 at eukaryotic elongation factor-2 kinase EEF2K HS.S49151 225546 at eukaryotic translation elongation factor 1 alpha 1 EEF1A1 HS.439552 204892 x at eukaryotic translation elongation factor 1 alpha 1 EEF1A1 HS.439552 206,559 X at eukaryotic translation elongation factor 1 alpha 1 F1A1 HS.439552 213477 x at eukaryotic translation elongation factor 1 alpha 1 F1A1 HS.439552 213614 x at eukaryotic translation elongation factor 1 beta 2 F1B2 HS.421608 200705 s at eukaryotic translation elongation factor 1 delta EEF1D HS.333388 203113 s at (guanine nucleotide exchange protein) Eukaryotic translation elongation factor 1 delta EEF1D HS.333388 214395 x at (guanine nucleotide exchange protein) eukaryotic translation elongation factor 1 epsilon 1 HS.88977 204905 s at Eukaryotic translation elongation factor 1 epsilon 1 HS.88977 213907 at eukaryotic translation initiation factor 1A, X-linked HS.S22590 201019 s at eukaryotic translation initiation factor 2, Subunit 1 Hs...151777 201143 s at alpha, 35 kDa eukaryotic translation initiation factor 2, Subunit 2 EIF2S2 HS.42918O 208726 s at beta, 38 kDa Eukaryotic translation initiation factor 2, Subunit 3 EIF2S3 HS.S39684 224935 at gamma, 52 kDa eukaryotic translation initiation factor 2, Subunit 3 EIF2S3 HS.S39684 224936 at gamma, 52 kDa eukaryotic translation initiation factor 2-alpha EIF2AK1 HS.S2O2OS 217736 s at kinase 1 eukaryotic translation initiation factor 2B, subunit 2 EIF2B2 HS.4091.37 202461 at beta, 39 kDa eukaryotic translation initiation factor 2C, 3 EIF2C3 HS.S3O333 219426 at eukaryotic translation initiation factor 3, Subunit 10 EIF3S10 HS.S23299 200595 S at theta, 150/170 kDa eukaryotic translation initiation factor 3 subunit 10 EIF3S10 HS.S23299 200596 s at theta, 150/170 kDa eukaryotic translation initiation factor 3, Subunit 6 EIF3S6 HS.405590 208697 s at 48 kDa Eukaryotic translation initiation factor 3, Subunit 6 EIF3S6 HS.405590 235429 at 48 kDa Eukaryotic translation initiation factor 3, Subunit 6 EIF3S6 HS.405590 236989 at 48 kDa eukaryotic translation initiation factor 3, Subunit 6 EIF3S6IP HS.446852 217719 at interacting protein eukaryotic translation initiation factor 3, Subunit 9 EIF3S9 HS.371 OO1 203462 x a eta, 116 kDa eukaryotic translation initiation factor 3, Subunit 9 EIF3S9 HS.371 OO1 208688 x a eta, 116 kDa eukaryotic translation initiation factor 4 gamma, 1 EIF4G1 HS.4337SO 208.624 S a eukaryotic translation initiation factor 4 gamma, 1 EIF4G1 HS.4337SO 208.625 s a eukaryotic translation initiation factor 4 gamma, 2 EIF4G2 HS.183684 200004 a

... eu otic translation initiation factor 4 gamma, 2 eukaryotic translation initiation factor 4 gamma, 3 E HS.467084 1554.309 at eukaryotic translation initiation factor 4 gamma, 3 E HS.467084 201935 s a Eukaryotic translation initiation factor 4 gamma, 3 E HS.467084 243149 a eukaryotic translation initiation factor 4A, isoform 1 E HS.129673 201530 x a Eukaryotic translation initiation factor 4A, isoform 1 E HS.129673 214805 a eukaryotic translation initiation factor 4A, isoform 2 E HS.478SS3 1556350 a. at eukaryotic translation initiation factor 4A, isoform 2 E HS.478SS3 200912 s a eukaryotic translation initiation factor 4B E HS.S12629 211938 a eukaryotic translation initiation factor 4E E HS.249718 201435 s a eukaryotic translation initiation factor 4E E HS.249718 201437 s a eukaryotic translation initiation factor 4E E HS.249718 237718 a eukaryotic translation initiation factor 4E binding E HS.S22995 20877O S a protein 2 Eukaryotic translation initiation factor 4E binding EIF4EBP2 HS.S22995 224653 a protein 2 eukaryotic translation initiation factor 4E member 2 EIF4E2 HS.292026 213571 s a Eukaryotic translation initiation factor 4E member 2 EIF4E2 HS.292026 226734 a US 2006/01992.04 A1 Sep. 7, 2006 32

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID eukaryotic translation initiation factor 5 EIF5 HS.433702 208290 s at eukaryotic translation initiation factor 5 EIF5 HS.433702 208705 S at eukaryotic translation initiation factor 5 EIF5 HS.433702 208706 s at eukaryotic translation initiation factor 5 EIF5 HS.433702 208707 a eukaryotic translation initiation factor 5 EIF5 HS.433702 2087.08 X at eukaryotic translation initiation factor 5A EIFSA HS.534314 201123 s at eukaryotic translation initiation factor 5A2 EIFSA2 HS.164144 235296 a Ewing sarcoma breakpoint region 1 EWSR1 HS.374477 209214 S at Ewing sarcoma breakpoint region 1 EWSR1 HS.374477 210011 s at Ewing sarcoma breakpoint region 1 EWSR1 HS.374477 229966 a excision repair cross-complementing rodent repair ERCC5 HS.258429 202414 a deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)) excision repair cross-complementing rodent repair ERCC6 207347 a deficiency, complementation group 6 exosome component 3 EXOSC3 S.54.9154 227916 x at exosome component 3 EXOSC3 S.54.9154 233495 a exosome component 8 EXOSC8 S.294O41 215136 s at Exostoses (multiple) 1 EXT1 S.4926.18 15643781 a. at Exostoses (multiple) 1 EXT1 S.4926.18 215206 a Exostoses (multiple) 1 EXT1 S.4926.18 232174 a Exostoses (multiple) 1 EXT1 S.4926.18 234634 a Exostoses (multiple) 1 EXT1 S.4926.18 239227 a exostoses (multiple)-like 2 EXTL2 S.357637 209537 a Exportin 7 XPO7 S.172685 235796 a exportin, tRNA (nuclear export receptor for tRNAs) XPOT S.85951 212160 a F11 receptor F11R S.S17293 223000 S at Factor for adipocyte differentiation 158 FAD158 S.412836 1570007 at actor for adipocyte differentiation 158 FAD158 S.412836 223533 a amily with sequence similarity 13, member A1 FAM13A1 S.97270 202973 X at amily with sequence similarity 18, member B FAM18B S.87295 21844.6 s at amily with sequence similarity 20, member A FAM2OA S.268.874 24.1981 a amily with sequence similarity 20, member A FAM2OA S.268.874 242945 a. Family with sequence similarity 20, member C FAM20C S.3703S4 244457 a amily with sequence similarity 21, member C fif FAM21C S.365286 211068 x at amily with sequence similarity 21, member C amily with sequence similarity 26, member C FAM26C S.S3O398 1554367 at amily with sequence similarity 3, member C FAM3C S.434053 201889 a amily with sequence similarity 32, member A FAM32A HS.4766 201863 a amily with sequence similarity 33, member A FAM33A S.4636O7 225.684 a amily with sequence similarity 35, member A FAM3SA S.500419 220547 s at amily with sequence similarity 36, member A FAM36A S.411490 224824 a amily with sequence similarity 40, member A FAM40A S.169577 225226 a Family with sequence similarity 40, member A FAM40A S.169577 228944 a amily with sequence similarity 41, member C fif FAM41C S.449006 232899 a similar to RPL23AP7 protein MGCfO863 amily with sequence similarity 44, member C FAM44C S.127882 231368 a amily with sequence similarity 45, member B if FAM4SB S.434241 221804 S at amily with sequence similarity 45, member A FAM45A amily with sequence similarity 46, member C FAM46C S.356216 220306 a amily with sequence similarity 46, member C FAM46C S.356216 226811 a amily with sequence similarity 48, member A FAM48A S.435815 216682 s a amily with sequence similarity 48, member A FAM48A S.435815 220408 x a amily with sequence similarity 48, member A FAM48A S.435815 221774 x a amily with sequence similarity 49, member B FAM49B S.492869 217916 s a amily with sequence similarity 53, member C FAMS3C S.54.056 218023 s a amily with sequence similarity 54, member A FAM54A S.121536 228069 at amily with sequence similarity 59, member A FAMS9A S.444314 219377 at amily with sequence similarity 60, member A FAM60A S.SOS154 22O147 s a amily with sequence similarity 60, member A FAM60A S.SOS154 223.038 s a amily with sequence similarity 61, member A FAM61A S.4O7368 212132 at amily with sequence similarity 61, member A FAM61A S.4O7368 222099 s a amily with sequence similarity 8, member A1 FAM8A1 S.95260 203420 at Fanconi anemia, complementation group C EANCC 205189 s a Fanconi anemia, complementation group D2 EANCD2 1568889 at Fanconi anemia, complementation group F FANCF 222713 s a US 2006/01992.04 A1 Sep. 7, 2006 33

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID airnesyl diphosphate synthase (farnesyl FDPS S.335918 201275 a pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) airnesyl-diphosphate farnesyltransferase 1 FDFT1 S.S46253 2O8647 a Farnesyl-diphosphate farnesyltransferase 1 FDFT1 S.S46253 238666 a Farnesyl-diphosphate farnesyltransferase 1 FDFT1 S.S46253 241954 a arnesyltransferase, CAAX box, alpha fif FNTA S.370312 200090 a airnesyltransferase, CAAXbox, alpha Fas (TNF receptor Superfamily, member 6) FAS S.244.139 204780 s at asciculation and elongation protein zeta 1 (Zygin I) FEZ1 S.2240O8 203562 a ascin homolog 3, actin-bundling protein, testicular FSCN3 S.1284O2 220379 a (Strongylocentrotus purpuratus) asting-inducible integral membrane protein TM6P1 S.3561.87 226239 a FAT tumor Suppressor homolog 1 (Drosophila) S.481371 201579 a FAT tumor suppressor homolog 3 (Drosophila) S.98523 236029 a atty acid 2-hydroxylase S.461329 219429 a atty acid binding protein 5 (psoriasis-associated) S.408061 202345 s at atty acid binding protein 5 (psoriasis-associated) S.408061 236271 a -box and leucine-rich repeat protein 11 S.124147 208988 a -box and leucine-rich repeat protein 12 S.12439 22O127 s at -box and leucine-rich repeat protein 13 S.434284 1553798 a. at -box and leucine-rich repeat protein 14 S.367956 213145 a. -box and leucine-rich repeat protein 17 S.112143 227203 a -box and leucine-rich repeat protein 20 S.462946 235089 a -box and WD-40 domain protein 12 S.288793 215600 x at -box and WD-40 domain protein 2 S.494985 218941 a -box and WD-40 domain protein 9 S.S15154 223419 a box protein 10 S.130774 227222 a box protein 11 S.5492O1 203255 a. box protein 15 S.465411 231472 a box protein 21 S.159699 212229 s at box protein 28 S.64691 1555971 S. at box protein 33 S.324342 226970 a box protein 34 S.S2S348 218539 a box protein 38 fit F-box protein 38 S.483772 221257 x at box protein 45 S.S18526 225,099 a box protein 45 S.S18526 225100 a box protein 7 S.5912 1554.423 a at box protein 7 S.5912 201178 a box protein 8 S.769.17 1554806 a. at -box protein 9 S.216653 1566509 S at -box protein 9 S.216653 210638 s at -box protein 9 S.216653 212991 a Fc fragment of IgE, high affinity I, receptor for; S.4333OO 204232 a gamma polypeptide Fc receptor-like protein 3 FCRH3 S.2924.49 231093 a FCH and double SH3 domains 2 FCHSD2 S.445748 242563 a FCH domain only 2 FCHO2 S.165762 228220 a er (fps/fes related) tyrosine kinase FER S.221472 206412 a (phosphoprotein NCP94) er-1-like 3, myoferlin (C. elegans) FER1L3 S.SOOS72 201798 s at FERM and PDZ domain containing 2 FRMPD2 S.S32437 239275 a. FERM domain containing 3 FRMD3 S.12753S 2298.93 a FERM domain containing 3 FRMD3 S.12753S 230645 a. FERM domain containing 4A FRMD4A S.SS2599 1554034 a at FERM domain containing 4A FRMD4A S.SS2599 225167 a FERM, RhoGEF (ARHGEF) and pleckstrin domain FARP1 S.403917 239246 a protein 1 (chondrocyte-derived) erredoxin 1 FDX1 S.744 203647 s at erritin, heavy polypeptide 1 FTH1 S.446.345 200748 s at erritin, heavy polypeptide pseudogene 1 ferritin, FTHP1 S.453.583 211628 x at heavy polypeptide pseudogene 1 etal Alzheimer antigen FALZ S.444200 20718.6 s at etal Alzheimer antigen FALZ S.444200 231953 at etal Alzheimer antigen FALZ S.444200 232909 s at Fetuin B FETUB S.8.1073 214417 s at FGFR1 oncogene partner FGFR1OP S.487175 1568678 s at FGFR1 oncogene partner FGFR1OP S.487175 205588. S. at FGFR1 oncogene partner 2 FGFR1OP2 S.406184 1556283 s at fibrillarin fibrillarin FBL S.299OO2 211623 s at US 2006/01992.04 A1 Sep. 7, 2006 34

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID brinogen-like 1 S.491143 2O5305 at ibroblast growth factor 12 S.185577 1562794 at broblast growth factor 13 S.6540 205110 s. at ibroblast growth factor 18 S.87191 231382 at broblast growth factor 9 (glia-activating factor) S.111 2064.04 at broblast growth factor receptor 1 (fms-related S.549O34 215404 x at tyrosine kinase 2, Pfeiffer syndrome) Fibroblast growth factor receptor 1 (fms-related 241724 x at tyrosine kinase 2, Pfeiffer syndrome) bromodulin FMOD S.519168 202709 at bronectin type III and ankyrin repeat domains 1 FANK1 S.352591 232968 at ibronectin type III domain containing 3A FNDC3A S.508O1O 228534 S at bronectin type III domain containing 3B FNDC3B S.15943O 2186.18 s at ibronectin type III domain containing 3B FNDC3B S.15943O 244022 at bronectin type III domain containing 5 FNDC5 S.524234 226097 at amin C, gamma (actin binding protein 280) FLNC S.58414 207876 s at Finkel-Biskis-Reilly murine sarcoma virus (FBR FAU 200019 s at MuSV) ubiquitously expressed (fox derived): ribosomal protein S30 if Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30 S S.8373 239380 a K506 binding protein 1A, 12 kDa S.47 1933 200709 a K506 binding protein 1A, 12 kDa S.47 1933 210187 a K506 binding protein 3, 25 kDa S.509226 218003 s at K506 binding protein 5 S.407190 224840 a K506 binding protein 7 S.410378 224002 s at KSG17 S.4584OO 211445 X at KSG44 gene S.362974 227964 a avin containing monooxygenase 5 S.3O3476 205776 a LJOO290 protein S.535044 236467 a LJ10378 protein S.480712 1554038 at LJ10378 protein S.480712 231011 a LJ10378 protein S.480712 231824 a LJ10378 protein S.480712 242153 a LJ16287 protein S.529141 1569077 X at LJ20160 protein S.418581 225325 a. LJ20259 protein S.297389 20917.4 S at LJ20859 gene S.512693 218366 x at LJ20859 gene S.512693 223528 s at LJ20859 gene S.512693 223988 x at LJ25323 protein S.S34649 239977 a LJ27505 protein S.177983 237428 a LJ30851 protein S.4678.68 230435 a. LJ34306 protein S.SOO495 229962 a LJ34870 protein S.27OO83 1561135 at LJ37099 protein S.127350 233294 a LJ41131 protein S.S9839 222052 a LJ41603 protein S.2562O6 22.7717 a LJ44216 protein S.348516 228805 a LJ45235 protein S.130054 236421 a LJ45803 protein S.125166 238701 x at LJ46072 protein S.67776 226129 a LN29 gene product S.5148 35254 at olate receptor 1 (adult) fit folate receptor 1 (adult) S.73769 211074 a ollicular lymphoma variant translocation 1 S.74OSO 202419 a Follistatin-like 4 S.483390 1565909 at orkhead box C1 S.348883 213260 a orkhead box C2 (MFH-1, mesenchyme forkhead S.436448 239058 a ) orkhead box J3 217310 s at orkhead box K2 S.132161 203064 S at Forkhead box O3A S.2209SO 1569477 at orkhead box O3A S.2209SO 204131 s at orkhead box O3A S.2209SO 224891 at Forkhead box O3A S.2209SO 242320 at Forkhead box P1 S.431.498 21.5221 at orkhead box P1 S.431.498 223937 at orkhead box P1 S.431.498 224837 at orkhead box P1 S.431.498 224838 at Forkhead box P1 S.431.498 244845 at US 2006/01992.04 A1 Sep. 7, 2006 35

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID orkhead box protein O6 239657 X at orkhead box Q1 S.297452 227475 a ormin binding protein 1-like S.134060 215017 s at Formin binding protein 1-like S.134060 242310 a ormin binding protein 3 S.298.735 213729 a ormin binding protein 3 S.298.735 218053 a Formin-like 3 S.179838 230850 a our and a half LIM domains 1 S.435369 214505 s at our and a half LIM domains 2 S.443687 202949 s at our and a half LIM domains 5 S.283.689 1555191 a. at FP6778 S.191482 225935 a. FP6778 S.191482 227O69 a racture callus 1 homolog (rat) FXC1 S.54943 217981 s at racture callus 1 homolog (rat) FXC1 S.54943 222481 a ragile X mental retardation, autosomal homolog 1 FXR1 S.4784O7 201635 S. at ragile X mental retardation, autosomal homolog 1 FXR1 S.4784O7 201637 S at requently rearranged in advanced T-cell FRAT1 S.126057 2198.89 a ymphomas lucosyltransferase 10 (alpha (1,3) FUT10 S.458713 235472 a lucosyltransferase) lucosyltransferase 11 (alpha (1,3) FUT11 S.SOOO82 238551 a lucosyltransferase) lucosyltransferase 2 (secretor status included) FUT2 S.44316O 210608 s at lucosyltransferase 3 (galactoside 3(4)-L- FUT3 S.169238 214088 s at lucosyltransferase, Lewis blood group included) lucosyltransferase 8 (alpha (1,6) FUT8 S.118722 242889 x at lucosyltransferase) Full length insert cDNA clone YSO2G11 S.S35341 242841 at Full length insert cDNA clone YT8SD04 S.38.4648 1561926 at Full length insert cDNA clone ZB55F04 S.142505 1557149 at Full length insert cDNA clone ZD69D05 S.3792S3 229994 at Full length insert cDNA clone ZD73HO4 S.126397 240539 at Full length insert cDNA clone ZD79H10 S.2238O 226272 at Full length insert cDNA YU10E03 S.SO8829 229026 at Full open reading frame cDNA clone S.55468 230795 at RZPDo834CO824D for gene HIST2H4, histone 2, H4; complete cols, incl. stopcodon Full-length cDNA clone CSODCOO1YL20 of 238833 at Neuroblastoma Cot 25-normalized of Homo Sapiens (human) Full-length cDNA clone CSODE002YJ16 of S.287759 232513 x at Placenta of Homo sapiens (human) Full-length oDNA clone CSODF027YF 17 of Fetal S.389452 242323 at brain of Homo sapiens (human) Full-length cDNA clone CSODFO38YJ21 of Fetal S.SS1805 222361 at brain of Homo sapiens (human) Full-length cDNA clone CSODIO53YO09 of S.151692 239017 at Placenta Cot 25-normalized of Homo sapiens Full-length cDNA clone CSODIO62YF05 of S.S36889 235829 at Placenta Cot 25-normalized of Homo sapiens Full-length cDNA clone CSODM002YA18 of Fetal S.436379 228240 at iver of Homo sapiens (human) umarylacetoacetate hydrolase domain containing 1 FAHD1 226767 s at umarylacetoacetate hydrolase domain containing 1 FAHD1 227960 S at FUN14 domain containing 2 FUNDC2 223.042 s at FUS interacting pro ein (serine-arginine rich) 1 FUSIP1 213594 x at used toes homolog (mouse) FTS 223894 S at usion (involved in (12; 16) in malignant FUS 200959 at iposarcoma) FXYD domain containing ion transport regulator 3 FXYD3 S.3013 SO 2024.88 s at FYN oncogene related to SRC, FGR, YES FYN S.390S67 2101.05 s at FYN oncogene related to SRC, FGR, YES FYN S.390S67 243006 at FYVE and coiled-coil domain containing 1 FYCO1 S.200227 244145 at FYVE, RhoGEF and PH domain containing 4 FGD4 S.117835 227948 at G kinase anchoring protein 1 GKAP1 S.S2225S 229311 at G kinase anchoring protein 1 GKAP1 S.S2225S 229312 s at G kinase anchoring protein 1 GKAP1 S.S2225S 234.192 s at G patch domain containing 2 GPATC2 S.42O757 1556126 s at G protein-coupled receptor 18 GPR18 S.549036 210279 at US 2006/01992.04 A1 Sep. 7, 2006 36

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID G protein-coupled receptor 56 GPRS6 S.S13633 212070 at G protein-coupled receptor 61 GPR61 S.514690 244618 at G protein-coupled receptor 89 GPR89 S.3193O1 220642 x at G protein-coupled receptor kinase 4 GRK4 S.32959 210600 s at G1 to S phase transition 1 GSPT1 S.S2878O 240452 at G1 to S phase transition 2 i? G1 to S phase GSPT2 S.S9523 205541 s at transition 2 G-2 and S-phase expressed 1 ff G-2 and S-phase GTSE1 S.386189 211040 x at expressed 1 GA binding protein transcription factor, alpha GABPA S473470 227428 at subunit 60 kDa GABA(A) receptor-associated protein GABARAP S.84359 200645 at GABA(A) receptor-associated protein like 1 GABARAPL1 S.S242SO 2088.68 s at GABA(A) receptor-associated protein like 1 GABARAPL1 S.S242SO 208869 s at GABA(A) receptor-associated protein-like 2 GABARAPL2 S.461379 20904.6 s at galactosamine (N-acetyl)-6-sulfate Sulfatase GALNS S.271383 206335 at (Morquio syndrome, mucopolysaccharidosis type IVA) galactosylceramidase (Krabbe disease) GALC S.513439 211810 s at gamma tubulin ring complex protein (76p gene) 76P S.S4913S 211337 s at gamma-aminobutyric acid (GABA) A receptor, beta 3 S.3O2352 229724 at gamma-glutamyl hydrolase (conjugase, S.78619 203560 at folylpolygammaglutamyl hydrolase) gamma-glutamyltransferase S.287SOS 207131 x at gamma-glutamyltransferase S.287SOS 208284 x at gamma-glutamyltransferase-like activity 4 S.3SS394 211416 X at GATA binding protein 3 S.524134 209604 S at Gem (nuclear organelle) associated protein 4 S.49962O 223783 sat Gene differentially expressed in prostate S.104215 1554591 at gene model 83 S.S32265 22567.6 s at gene model 83 S.S32265 231784 S at general transcription factor II, if general S.S2O459 201065 s at transcription factor II, i, pseudogene 1 general transcription factor II, if general 210891 s at transcription factor II, i, pseudogene 1 General transcription factor IIA, 1, 19/37 kDa S.51OO68 1559009 at general transcription factor IIA, 2, 12 kDa S.512934 202678 a General transcription factor IIA, 2, 12 kDa S.512934 230376 a General transcription factor IIA, 2, 12 kDa S.512934 243985 a general transcription factor IIE, polypeptide 1, S.445272 205930 a. alpha 56 kDa general transcription factor IIE, polypeptide 2, beta S.771 OO 202680 a 34 kDa general transcription factor IIF, polypeptide 1, S.68257 202356 s a 74 kDa general transcription factor IIH, polypeptide 1, 202451 a 62 kDa general transcription factor IIH, polypeptide 2, S.1913.56 221540 x a 44 kDa general transcription factor IIH, polypeptide 5 S.356224 213357 a geranylgeranyl diphosphate synthase 1 S.SS498 202321 a geranylgeranyl diphosphate synthase 1 S.SS498 202322 s a germ cell associated S.240053 241553 a germ cell associated 1 if germ cell associated 1 S.240053 221252 s a germ cell associated 2 (haspin) S.S34059 223759 S a germ cell-less homolog 1 (Drosophila) i? germ cell S.4843.13 234488 s a less homolog 1 (Drosophila)-like GLI-Kruppel family member HKR1 S.1291.65 227603 at Glioma amplified sequence 64 S.416155 238853 at glioma tumor Suppressor candidate region gene 2 S.421907 217807 s a glucocorticoid induced transcript 1 S.131673 225706 at glucosamine (UDP-N-acetyl)-2-epimerase/N- S.592O 205042 at acetylmannosamine kinase glucosamine-phosphate N-acetyltransferase 1 GNPNAT1 S.478O2S 225853 at glucosaminyl (N-acetyl) transferase 3, mucin type GCNT3 S.19471O 219508 at glucose phosphate isomerase GPI S.466471 208308 s at glucosidase, alpha; neutral AB GANAB S.76847 214626 s at Glucosidase, beta (bile acid) 2 GBA2 S.443134 228292 at glutamate dehydrogenase 2 GLUD2 S.368538 215794 X at glutamate receptor, ionotropic, N-methyl D GRINL1A S.4372S6 212241 at aspartate-like 1A US 2006/01992.04 A1 Sep. 7, 2006 37

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set amate receptor, metabotropic 6 GRM6 S.248.131 208035 a. amate- ligase (glutamine synthase) GLUL S.S1852S 200648 s at amate-ammonia ligase (glutamine synthase) GLUL S.S1852S 215001 s at amate-ammonia ligase (glutamine synthase) GLUL S.S1852S 217202 s at amate-cysteine ligase, catalytic Subunit GCLC S.271264 aminase GLS S.116448 203159 a utamine-fructose-6-phosphate transaminase 1 GFPT1 S.468864 1560596 at aminyl-tRNA synthetase QARS S.79322 217846 a amyl-prolyl-tRNA synthetase EPRS S.497788 2 O0842 s at aredoxin 2 GLRX2 S.458283 219933 a athione peroxidase 4 (phospholipid GPX4 S.433951 201106 a roperoxidase) utathione S-transferase A1 GSTA1 S.446309 5766 a athione S-transferase kappa 1 GSTK1 S.390667 7751 a athione S-transferase M1 GSTM1 S.3O1961 5333 x at athione S-transferase M2 (muscle) GSTM2 S.279837 O4418 x at athione S-transferase M3 (brain) GSTM3 S.2006 O2554 S at athione S-transferase M3 (brain) GSTM3 S.2006 35867 a athione S-transferase M4 GSTM4 S.348387 O912 x at athione S-transferase M5 GSTMS S.75652 05752 S at athione S-transferase omega 1 GSTO1 S.190O28 O1470 a athione synthetase GSS S.82327 O1415 a. athione synthetase if glutathione synthetase GSS S.82327 1630 s at ycerol kinase 2 GK2 S.980O8 5430 a. ycerol-3-phosphate dehydrogenase 2 GPD2 S.148266 O007 s at (mitochondrial) Glycerol-3-phosphate dehydrogenase 2 GPD2 S.148266 243598 a (mitochondrial) glycerophosphodiester phosphodiesterase domain GDPD1 S.1534.85 1555606 a at containing 1 glycerophosphodiester phosphodiesterase domain GDPD3 S.289015 219722 s at containing 3 glycine cleavage system protein H (aminomethyl GCSEH S.546256 213129 s at carrier) glycine cleavage system protein H (aminomethyl GCSEH S.546256 213133 s at carrier) Glycine cleavage system protein H (aminomethyl IQWD1 S.435741 235613 at carrier) glycogen synthase kinase 3 alpha GSK3A S.466828 632 at Glycogen synthase kinase 3 beta GSK3B S.445733 2261.91 at glycogenin GYG S.477892 211275 s at ycolipid transfer protein GLTP S.381.256 226177 at ycoprotein (transmembrane) nmb GPNMB S.190495 2011.41 at ycoprotein VI (platelet) GP6 S.272,216 220336 s at ycosyltransferase 25 domain containing 2 GLT2SD2 S.387995 209883 at ycosyltransferase-like domain containing 1 GTDC1 S.4478O 220853 at glypican 2 (cerebroglycan) GPC2 S.211.701 239422 at GNAS complex GNAS S.125898 200780 x at GNAS complex locus GNAS S.125898 200981 X at GNAS complex locus GNAS S.125898 211858 x at GNAS complex locus GNAS S.125898 212273 x at GNAS complex locus GNAS S.125898 214157 at GNAS complex locus GNAS S.125898 228173 at golgi apparatus protein 1 GLG1 S.2O1712 214730 s at golgi associated PDZ and coiled-coil motif GOPC S.191539 227214 at containing Golgi associated PDZ and coiled-coil motif GOPC S.191539 236862 at containing golgi associated, gamma adaptin ear containing, GGA1 S.499158 45572 s at ARF binding protein 1 golgi associated, gamma adaptin ear containing, GGA1 S.499158 50277 at ARF binding protein 1 golgi associated, gamma adaptin ear containing, GGA2 S.460336 208913 at ARF binding protein 2 golgi associated, gamma adaptin ear containing, GGA2 S.460336 210658 s at ARF binding protein 2 golgi associated, gamma adaptin ear containing, GGA3 S.87726 211815 s at ARF binding protein 3 golgi autoantigen, golgin subfamily a, 3 GOLGA3 S.SOf333 1554987 at golgi autoantigen, golgin subfamily a 5 GOLGAS S.104320 218241 at US 2006/01992.04 A1 Sep. 7, 2006 38

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID golgi autoantigen, golgin subfamily a member 6 if GO LGA6 S.326.276 207575 at similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like LOC388137 protein) i? similar to COMM domain containing 4 golgi autoantigen, golgin subfamily b, macrogolgin GO S.213389 201057 s at (with transmembrane signal), 1 golgi phosphoprotein 3 (coat-protein) GO LPH3 S.408909 217803 at golgi phosphoprotein 4 GO LPH4 S.1436OO 238002 at golgi reassembly stacking protein 2, 55 kDa GO RASP2 S.431.317 207812 s at golgi reassembly stacking protein 2, 55 kDa GO RASP2 S.431.317 208842 s at golgi reassembly stacking protein 2, 55 kDa GO RASP2 S.431.317 208.843 s at golgi SNAP receptor complex member 1 GOSR1 S.46268O 204630 s at golgi SNAP receptor complex member 2 GOSR2 S.463278 213180 s at golgin-67 GO LGIN S.182982 208797 s at 67 golgin-67 GO LGIN S.182982 208798 X at 67 golgin-67 GO LGIN S.182982 213650 at 67 GPI deacylase PGAP1 S.229988 220576 at GPI7 protein GPIT S.7099 218652 s at grancalcin, EF-hand calcium binding protein GCA S.377894 203765 at grancalcin, EF-hand calcium binding protein GRINL1A complex upstream protein Gup1 S.SO841 228568 at GRIP and coiled-coil domain containing 1 GCC1 S.5211.68 218912 at growth arrest-specific 5 GASS S.S31856 228238 at growth factor receptor-bound protein 10 GR B10 S.164060 2094.09 at growth factor receptor-bound protein 10 GR B10 S.164060 210999 s a growth hormone inducible transmembrane protein GH TM S.352656 1554510 s. at Growth hormone inducible transmembrane protein GH TM S.352656 1564148 at growth hormone inducible transmembrane protein GH TM S.352656 209249 s a GTF2I repeat domain containing 2 GT F2IRD2 S.270962 228765 at GTP binding protein 4 GT PBP4. S.215766 218239 s a GTPase activating protein and VPS9 domains 1 GA PVD1 S.495134 212802 s a GTPase activating protein and VPS9 domains 1 GA PVD1 S.495134 214869 x a GTPase activating Rap/RangAP domain-like 1 GA RNL1 S.113150 234923 at GTP-binding protein PTD004 PTDOO4 S.157351 219293 s a guanine monphosphate synthetase GMPS S.546.324 214431 at guanine nucleotide binding protein (G protein) GNA12 S.487.341 224681 at alpha 12 guanine nucleotide binding protein (G protein), GNA11 S.S1SOS6 213766 x a alpha 11 (Gq class) guanine nucleotide binding protein (G protein), GNA11 S.S1SOS6 213944 x a alpha 11 (Gq class) guanine nucleotide binding protein (G protein), GNA11 S.S1SOS6 40562 at alpha 11 (Gq class) guanine nucleotide binding protein (G protein), GNA13 S.S15018 224761 at alpha 13 guanine nucleotide binding protein (G protein), GNB1 S.43O425 200745 s at beta polypeptide 1 Guanine nucleotide binding protein (G protein), GNB1 S.43O425 241865 at beta polypeptide 1 Guanine nucleotide binding protein (G protein), GNG10 S.SO1879 240326 at gamma 10 Guanine nucleotide binding protein (G protein), GNG2 S.187772 243819 at gamma 2 guanine nucleotide binding protein (G protein), GNG3 S.17991S 222005 s at gamma 3 Guanine nucleotide binding protein (G protein), GNG4 S.159711 1566512 at gamma 4 guanine nucleotide binding protein-like 1 GNL1 S.83147 203307 at Guanine nucleotide binding protein-like 1 GNL1 S.83147 233544 at guanylate binding protein 2, interferon-inducible GBP2 S.386567 242907 at guanylate cyclase activator 1A (retina) GUCA1A S.92858 1255 g at guanylate cyclase activator 1A (retina) GUCA1A S.92858 206062 at GULP, engulfment adaptor PTB domain containing 1 GULP1 S.470887 204235 S. at H19, imprinted maternally expressed untranslated H19 S.SS1588 224997 X at mRNA H2A histone family, member X S.477879 213344 S at H2A histone family, member Z S.119.192 213911 s at US 2006/01992.04 A1 Sep. 7, 2006 39

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID H3 histone, family 3A S.533624 20875S X at H3 histone, family 3A S.533624 211940 x at H3 histone, family 3A S.533624 213828 x at H3 histone, family 3A i? H3 histone, family 3A S.533624 200080 s at H3 histone, family 3B (H3.3B) S.18O877 209069 s at H3 histone, family 3B (H3.3B) S.18O877 211997 X at H3 histone, family 3B (H3.3B) S.18O877 211998 a H3 histone, family 3B (H3.3B) S.18O877 211999 a hairyienhancer-of-split related with YRPW motif. S.472566 226828 s at ike HBS1-like (S. cerevisiae) HBS1L S.378532 209316 s at headcase homolog (Drosophila) HECA S.197644 218603 a heat shock 10 kDa protein 1 (chaperonin 10) PE1 S.1197 205133 s at heat shock 60 kDa protein 1 (chaperonin) PD1 S.113684 200807 s at heat shock 70 kDa protein 1A PA1A S.520O28 200799 a heat shock 70 kDa protein 1B PA1B S.2744O2 202581 a heat shock 70 kDa protein 1-like PA1L, S.80288 210189 a heat shock 70 kDa protein 4-like PA4L S.13SSS4 205543 a heat shock 70 kDa protein 8 PA8 S.180414 221891 x at heat shock 90 kDa protein 1, alpha PCA S.S23S60 210211 s at heat shock 90 kDa protein 1, alpha PCA S.S23S60 211968 s at heat shock 90 kDa protein 1, alpha PCA S.S23S60 211969 a heat shock 90 kDa protein 1, alpha PCA S.S23S60 214328 s at heat shock factor binding protein 1 BP1 S.2SO899 200941 a heat shock transcription factor 2 binding protein F2BP S.406157 207020 a heat shock transcription factor, Y-linked 1 ff heat FY1 S.448418 224007 a shock transcription factor, Y linked 2 hect (homologous to the E6-AP (UBE3A) carboxyl s S.210385 218306 s at erminus) domain and RCC1 (CHC1)-like domain (RLD) 1 hect domain and RLD 4 S.51891 25988 at hect domain and RLD 5 S.26663 98.63 at HECT domain containing 2 S. 66378 27568 at HECT, UBA and WWE domain containing 1 S.1369 OS O8598 is a hematopoietic stem progenitor cells 176 C 1 7 6 S.461722 8354 at hemochromatosis S.23332S O6087 x a hemochromatosis S.23332S 1328 x a hemogen HEMGN S.176626 23670 s a heparan Sulfate (glucosamine) 3-O- HS3ST2 S.11583.0 9697 at Sulfotransferase 2 hepatitis B virus X associated protein S.42O229 218166 s a hepatitis B virus X associated protein S.42O229 222540 S a hepatitis B virus X interacting protein S.439815 202299 s a hepatitis B virus X interacting protein S.439815 202300 at hepatocellularcarcinoma-associated antigen S.S28351 213861 s a HCASS7a hepatocyte growth factor-regulated tyrosine kinase. HGS S.S14590 210428 s a Substrate hepatoma derived growth factor-like 1 S.97124 232680 at hepatoma-derived growth factor (high-mobility S.SO6748 200896 x a group protein 1-like) hepatoma-derived growth factor, related protein 3 HDGFRP3 S.S13954 209524 at hepatoma-derived growth factor, related protein 3 HDGFRP3 S.S13954 209526 s a hepatoma-derived growth factor, related protein 3 HDGFRP3 S.S13954 216693 x a Hepatoma-derived growth factor-related protein 2 HDGF2 S.43071 207730 X a Hermansky-Pudlak syndrome 5 PS5 S.437599 204544 at HERV-H LTR-associating 2 HHLA2 S.252351 234624 at HERV-H LTR-associating 3 HHLA3 S.14224.5 234665 x a HESB like domain containing 2 HBLD2 S.449291 209273 s a HESB like domain containing 2 HBLD2 S.449291 209274 S a HESB like domain containing 2 HESB like HBLD2 S.449291 221425 s a domain containing 2 heterogeneous nuclear ribonucleoprotein AB HNRPAB S.248746 201277 s a heterogeneous nuclear ribonucleoprotein AO HNRPAO S.96996 20105.5 s a Heterogeneous nuclear ribonucleoprotein AO HNRPAO S.96996 229083 at heterogeneous nuclear ribonucleoprotein A1 HNRPA1 S.546.261 214280 x a heterogeneous nuclear ribonucleoprotein A1 HNRPA1 S.546.261 200016 x a heterogeneous nuclear ribonucleoprotein A1 heterogeneous nuclear ribonucleoprotein A1 HNRPA1 S.S34833 213356 x a similar to Heterogeneous nuclear ribonucleoprotein US 2006/01992.04 A1 Sep. 7, 2006 40

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID A1 (He ix-destabilizing pro ein) (Single-strand LOC344741 binding protein) (hnRNP core protein A1) (HDP) f/ similar o Heterogeneous nuclear ribonucleopro ein LOC389674 A1 (He ix-destabilizing pro ein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) LOC391670 (Topoisomerase-inhi bitor suppressed) i? similar to Heterog eneous nuclear ribonucleoprotein A1 LOC4O2112 (Helix estabilizing protein) (Single-strand bin ing protein) (hnRNP core protein A1) (HDP) i? similar LOC4O2S62 o Heterogeneous nuclear ribonucleoprotein A1 (Helix estabilizing protein) (Single-strand bin ing LOC439963 protein) (hnRNP core protein A1) ( o Heterogeneous nuclear ribonucleoprotein A1 LOC44O12S (Helix estabilizing protein) (Single-strand bin ing protein) (hnRNP core protein A1) (HDP-1) LOC441SOf (Topoisomerase-inhibitor Suppressed) i? similar to heterogeneous nuclear ribonucleoprotein A1 similar o Heterogeneous nuclear ribonucleopro ein A1 (He ix-destabilizing pro ein) (Single-strand binding protein) (hnRNP core protein A1) (HD similar o Heterogeneous nuclear ribonucleopro ein A1 (He ix-destabilizing pro ein) (Single-strand binding protein) (hnRNP core protein A1) (HD P) heterogeneous nuclear ribonucleoprotein A1 HNRPA1 HSS34833 216559 X at similar o Hinirpal protein i? similar to Heterog eneous nuclear ribonucleoprotein A LOC12O364 (Helix estabilizing protein) (Single-strand bin ing protein) (hnRNP core protein A1) (HDP) / similar LOC344741 o Heterogeneous nuclear ri bonucleoprotein A1 (Helixix-destabilizing protein) (Single-strand bin ing LOC389674 protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor Suppressed) i? similar to LOC391670 Heterog eneous nuclear ribonucleoprotein A (Helix estabilizing protein) (Single-strand bin ing LOC4O2112 protein) (hnRNP core protein A1) (HDP) i? similar o Heterogeneous nuclear ri bonucleoprotein A1 LOC4O2S62 (H elix-destabilizing protein) (Single-strand bin ing protein) (hnRNP core protein A1) (HDP) i? similar LOC439963 o Heterogeneous nuclear ri bonucleoprotein A1 (Helixelix-destabilizing protein) (Single-strand bin ing LOC44O12S protein) (hnRNP core protein A1) (HDP-1) (Topoisom erase-inhibitor Suppressed) i? similar to heterogeneous nuclear ribonucleoprotein A1 similar o Heterogeneous nuclear ribonucleopro ein A1 (He ix-destabilizing pro ein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) heterogeneous nuclear ribonucleoprotein A1 HNRPA1 HSS34833 216497 at similar o Hinirpal protein i? similar to Heterog eneous nucleair ribonucleoprotein A LOC12O364 (Helix estabilizing protein) (Single-strand bin ing protein) (hnRNP core protein A1) (HDP) i? similar LOC344741 o Heterogeneous nuclear ri bonucleoprotein A1 (Helixix-destabilizing protein) (Single-strand bin ing LOC389674 protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor Suppressed) i? similar to LOC391670 Heterog eneous nucleair ribonucleoprotein A (Helix estabilizing protein) (Single-strand bin ing LOC4O2112 protein) (hnRNP core (HDP) /?/ similar o Heterogeneous nuclear ribonucleoprotein A1 LOC4O2S62 (Helix estabilizing protein) (Single-strand bin ing protein) (hnRNP core proteiin A1) (HDP) i? similar LOC439963 o Heterogeneous nuclear ribonucleoprotein A1 (Helix estabilizing protein) (Single-strand bin ing LOC44O12S protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor Suppressed) i? similar to LOC441507 heterogeneous nuclear ribonucleoprotein A1 similar o Heterogeneous nuclear ribonucleopro ein A1 (He ix-destabilizing pro ein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) f/ US 2006/01992.04 A1 Sep. 7, 2006 41

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) heterogeneous nuclear ribonucleoprotein A2, B1 HNRPA2B1 S.487774 205292 s at Heterogeneous nuclear ribonucleoprotein A2, B1 HNRPA2B1 S.487774 225932 S at heterogeneous nuclear ribonucleoprotein A3 HNRPA3 S.S16539 211932 at heterogeneous nuclear ribonucleoprotein A3 HNRPA3P1 S.524276 211931 s at pseudogene 1 if heterogeneous nuclear ribonucleoprotein A3 HNRPA3 heterogeneous nuclear ribonucleoprotein C HNRPC S.449114 212626 x a (C1/C2) heterogeneous nuclear ribonucleoprotein C HNRPC S.449114 214737 x a (C1/C2) heterogeneous nuclear ribonucleoprotein C HNRPC S.449114 200014 S a (C1/C2) if heterogeneous nuclear ribonucleoprotein C (C1/C2) heterogeneous nuclear ribonucleoprotein D-like HNRPDL S.S271 OS 201993 x a heterogeneous nuclear ribonucleoprotein D-like HNRPDL S.S271 OS 209067 s a Heterogeneous nuclear ribonucleoprotein D-like HNRPDL S.S271 OS 212454 X a heterogeneous nuclear ribonucleoprotein H1 (H) HNRPH1 S.202166 201031 s a heterogeneous nuclear ribonucleoprotein H3 (2H9) HNRPH3 S.4998.91 207127 s a heterogeneous nuclear ribonucleoprotein H3 (2H9) HNRPH3 S.4998.91 208990 s a heterogeneous nuclear ribonucleoprotein H3 (2H9) HNRPH3 S.4998.91 210110 x a heterogeneous nuclear ribonucleoprotein H3 (2H9) HNRPH3 S.4998.91 210588 x a heterogeneous nuclear ribonucleoprotein K if HNRPK S.S22257 200097 s a heterogeneous nuclear ribonucleoprotein K heterogeneous nuclear ribonucleoprotein L. HNRPL S.446623 35201 at Heterogeneous nuclear ribonucleoprotein M HNRPM S.4658O8 1555843 at heterogeneous nuclear ribonucleoprotein M HNRPM S.4658O8 1556084 at heterogeneous nuclear ribonucleoprotein R HNRPR S.373763 208766 s at heterogeneous nuclear ribonucleoprotein U HNRPU S.1664.63 200593 s at (scaffold attachment factor A) heterogeneous nuclear ribonucleoprotein U HNRPU S.1664.63 200594 x at (scaffold attachment factor A) hexokinase 2 HK2 S.406266 202934 at high density lipoprotein binding protein (vigilin) HDLBP S.47 1851 221767 X at high mobility group nucleosomal binding domain 3 HMGN3 S. 77558 209377 s at high-mobility group box 1 HMGB1 S.434102 200680 x at high-mobility group box 1 HMGB1 S.434102 214938 x at high-mobility group box 1 HMGB1 S.434102 224731 at high-mobility group nucleosomal binding domain 2 HMGN2 S.181163 208668 x at high-mobility group nucleosome binding domain 1 HMGN1 S.35628S 200943 at high-mobility group nucleosome binding domain 1 HMGN1 S.35628S 200944 S at hippocalcin-like 1 HPCAL1 S.467696 212552 at HIR histone cell cycle regulation defective homolog HIRA S.4742O6 240451 at A (S. cerevisiae) HIRA interacting protein 5 HIRIP5 S.43O439 218946 at histamine receptor H3 HRH3 S.251.399 1555715 a. at histidine triad nucleotide binding protein 1 HINT1 S.483305 1555961 a. at histidine triad nucleotide binding protein 2 fif HINT2 S.7.0573 224415 S a histidine triad nucleotide binding protein 2 histone 1, H2bc HIST1H2BC S.546314 236193 a histone 1, H2bd HIST1H2BD S.130853 209911 X a histone 1, H4d HIST1H4D S.248179 208076 a histone 2, H2aa HIST2H2AA S.53O461 218280 x a histone 2, H2be HIST2H2BE S.2178 202708 s a histone acetyltransferase 1 HAT1 S.47O611 2031.38 a histone deacetylase 2 HDAC2 S.3352 201833 a histone deacetylase 3 HDAC3 S.519632 216326 s a Histone deacetylase 3 HDAC3 S.519632 240482 a histone deacetylase 9 HDAC9 S.196054 234393 a HIV TAT specific factor 1 HTATSF1 S.204475 202602 s a HIV-1 induced protein HIN-1 HSHIN1 S.270851 203480 s a HIV-1 Rev binding protein HRB S.443507 218091 a HIV-1 Rev binding protein HRB S.443507 218092 s a HIV-1 rev binding protein 2 HRB2 S.2698.57 232441 a HIV-1 Tat interactive protein 2, 30 kDa HTATIP2 S.907S3 209448 a HIV-1 Tat interactive protein 2, 30 kDa HTATIP2 S.907S3 2102.53 a HLA class II region expressed gene KE2 HKE S.446.374 242048 a HLA complex group 18 HCG18 S.3O1985 242812 a HLA complex group 2 pseudogene 7 HCG2P7 S.S12758 216229 x at US 2006/01992.04 A1 Sep. 7, 2006 42

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID HLA complex group 8 215985 a HLA-B associated transcript 3 BAT3 S.44O900 210208 x at HLA-G histocompatibility antigen, class I, G HLA-G S.S12152 211528 x at HMG2 like LOC127540 S.4O93O7 230473 s at HMT1 hnRNP methyltransferase-like 4 (S. cerevisiae) HRMT1L4 S.S.04530 230839 a Holocarboxylase Synthetase (biotin-proprionyl HLCS S.371350 241726 a Coenzyme A-carboxylase (ATP-hydrolysing) igase) Homeo box A13 HOXA13 S.414467 238,571 a homeo box A3 HOXA3 S.533357 23.5521 a homeo box B9 HOXB9 S.463350 226461 a homeo box C4 i? hypothetical gene Supported by HOXC4 S.3SO378 206194 a AKO22887: AKO56417 FLJ1282S homeo box C6 HOXC6 S.820 206858 s at Homeo box D8 HOXD8 S.3O1963 231906 a Homeobox C14 LOC360O3O S.484779 232744 x at homeodomain interacting protein kinase 1 HIPK1 S.S323.63 1552515 at homeodomain interacting protein kinase 1 HIPK1 S.S323.63 212291 a Homeodomain interac ing protein kinase 2 HIPK2 S.39746S 2251.16 a homeodomain interacting protein kinase 3 HIPK3 S.2O1918 207764 S at homer homolog (Drosophila) HOMER1 S.129051 226651 a Homo sapiens, clone IMAGE: 2900578, m. RNA, S.37S766 227710 S at partial cols Homo sapiens, clone IMAG 3604678, m RNA S.S27697 227484 a Homo sapiens, clone IMAG 3930408, m RNA S.34O68 235.010 a Homo sapiens, clone IMAG : 4044872, m RNA S.205745 569344 a at Homo sapiens, clone IMAG : 4096273, m RNA S.4055 555832 sat Homo sapiens, clone IMAG : 4096273, m RNA S.4055 Homo sapiens, clone IMAG : 4214313, m RNA S.288478 Homo sapiens, clone IMAG : 4214654, m RNA S.161.93 Homo sapiens, clone IMAG : 4214654, m RNA S.161.93 Homo sapiens, clone IMAG : 4246459, m RNA S.S16739 Homo sapiens, clone IMAG : 440 1608, m RNA S.1621 OS Homo sapiens, clone IMAG : 4523945, m RNA S.128770 Homo sapiens, clone IMAG : 4700331, m RNA S.S41578 570269 a Homo sapiens, clone IMAG : 4723407, m RNA S.374729 563138 a partial cols Homo sapiens, clone IMAG : 4747087, m. RNA S.4873.93 226715 a. Homo sapiens, clone IMAG : 4798168, m RNA S.SSO817 568799 a Homo sapiens, clone IMAG : 4819956, m RNA S.127043 563367 a partial cols Homo sapiens, clone IMAG : 4822139, m RNA S.456065 556.263 s at Homo sapiens, clone IMAG : 4822266, m RNA S385810 568887 a Homo sapiens, clone IMAG : 4822684, m RNA S.S.06258 568915 a. Homo sapiens, clone IMAG : 4822830, m RNA S.33O376 560135 a. Homo sapiens, clone IMAG : 4822875, m RNA S.S3S410 215504 x at Homo sapiens, clone IMAG : 4823092, m RNA S.145221 557838 a Homo sapiens, clone IMAG : 4823221, m RNA S.99503 568872 a. Homo sapiens, clone IMAG : 4823340, m RNA S.144492 563103 a Homo sapiens, clone IMAG : 4825762, m RNA S.27S746 561877 a Homo sapiens, clone IMAG : 4825783, m RNA S.SS3019 561618 a Homo sapiens, clone IMAG : 4826526, m RNA S.191814 557645 a. Homo sapiens, clone IMAG : 4827386, m RNA S.S27876 570372 a. Homo sapiens, clone IMAG : 4828652, m RNA S.319053 569646 a. at Homo sapiens, clone IMAG : 4828738, m RNA S.S19887 560070 a Homo sapiens, clone IMAG : 4829423, m RNA S.122199 240685 at Homo sapiens, clone IMAG : 4829846, m RNA S.156898 568711 a. at Homo sapiens, clone IMAG : 4830945, m RNA S.401404 556.850 a Homo sapiens, clone IMAG : 4831083, m RNA S.3856.30 569786 a Homo sapiens, clone IMAG : 4837645, m RNA, S.1497.62 560634 a at partial cols Homo sapiens, clone IMAG : 4837650, m RNA, S.363.526 23.5696 at partial cols Homo sapiens, clone IMAG : 4837974, m RNA S.4O7594 561598 at Homo sapiens, clone IMAG : 483.8968, m RNA S.549478 237260 at Homo sapiens, clone IMAG : 4839037, m RNA S.515075 562276 at Homo sapiens, clone IMAG 5O19307, m RNA S.445239 Homo sapiens, clone IMAG 5103171, m RNA, S.408584 partial cols Homo sapiens, clone IMAG : 5165176, m RNA S.504540 562674 at US 2006/01992.04 A1 Sep. 7, 2006 43

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID

Homo sapiens, c Ole MAG 5166236, m RNA S.479288 241432 at Homo sapiens, c Ole MAG 5166543, m RNA S.4O7621 559806 a Homo sapiens, c Ole MAG 5167446, m RNA S.1OS323 556183 a Homo sapiens, c Ole MAG 5167600, m RNA S.178144 235736 at Homo sapiens, c Ole MAG 5168221, m RNA S.254230 564685 a. at Homo sapiens, c Ole MAG 5169759, m RNA S.S25499 570234 a Homo sapiens, c Ole MAG 5170410, m RNA S.434359 563.039 a Homo sapiens, c Ole MAG 5170855, m RNA S.257807 563115 a. Homo sapiens, c Ole MAG 5171618, m RNA S.11206S 560282 a Homo sapiens, c Ole MAG 5215917, m RNA S.549.543 228826 at Homo sapiens, c Ole MAG 5218705, m RNA S.334269 559220 a Homo sapiens, c Ole MAG 5222445, m RNA S.434728 560517 s at Homo sapiens, c Ole MAG 5225645, m RNA S.S35921 559870 a Homo sapiens, c Ole MAG 5244076, m RNA S.S28.230 560225 a. Homo sapiens, c Ole MAG 5260583, m RNA S.311402 55835.4 S at Topoisomerase ( DNA) I S.472737 Homo sapiens, c Ole MAG 5261213, m RNA S.371.609 228315 at Homo sapiens, c Ole MAG 5261865, m RNA S.S47136 56O131 a Homo sapiens, c Ole MAG 5265638, m RNA S.129283 56.9996 a Homo sapiens, c Ole MAG 5266257, m RNA S.146285 56.8791 s at Homo sapiens, c Ole MAG 5266772, m RNA S.126OOS 568663 a at Homo sapiens, c Ole MAG 5267277, m RNA S.407613 557875 a. Homo sapiens, c Ole MAG 5267398, m RNA S.40289 Homo sapiens, c Ole MAG 5267398, m RNA S.40289 Homo sapiens, c Ole MAG 5267453, m RNA S.88594 Homo sapiens, c Ole MAG 5267606, m RNA S.371732 556518 a Homo sapiens, c Ole MAG 5268616, m RNA S.12SSO3 559344 a Homo sapiens, c Ole MAG 5268696, m RNA S.90286 226546 at Homo sapiens, c Ole MAG 5269228, m RNA S.125983 556617 a. at Homo sapiens, c Ole MAG 5269899, m RNA S.21965 237365 at Homo sapiens, c Ole MAG 5270538, m RNA S.292105 55.7491 a Homo sapiens, c Ole MAG 5271876, m RNA S.125923 559540 a Homo sapiens, c Ole MAG 5272062, m RNA S.2O2419 556913 a at Homo sapiens, c Ole MAG 5272174, m RNA S.4O9982 568784 a Homo sapiens, c Ole MAG 5272174, m RNA S.4O9982 568785 a. at Homo sapiens, c Ole MAG 5272626, m RNA S.S11837 561705 a. Homo sapiens, c Ole MAG 5273537, m RNA S.97740 244325 at Homo sapiens, c Ole MAG 5273707, m RNA S.541333 566689 a Homo sapiens, c Ole MAG 5274897, m RNA S.351,680 225225 at Homo sapiens, c Ole MAG 5276804, m RNA S.S35008 242305 at Homo sapiens, c Ole MAG 5278284, m RNA S.4386.23 231992 x at Homo sapiens, c Ole MAG 5278517, m RNA S.S17821 224644 at Homo sapiens, c Ole MAG 5285282, m RNA S.370O49 227917 at MRNA, cDNA DKFZp434N2116 (from clone S.448067 CDNA FLJ39459 fis, clone S.491069 PROST2O11439. Homo sapiens, c Ole MAG 5288537, m RNA S.451353 226137 at Homo sapiens, c Ole MAG 5288946, m RNA S.375804 1561560 at Homo sapiens, c Ole MAG 5295612, m RNA S.SS2762 1568615 a. at Homo sapiens, c Ole MAG 5296329, m RNA S.178067 231191 at Homo sapiens, c Ole MAG 5297356, m RNA S.382O14 240828 at Homo sapiens, c Ole MAG 5298.702, m RNA S.407545 1568908 at Homo sapiens, c Ole MAG 53.12078, m RNA S.327170 1569416 at Homo sapiens, c Ole MAG 5480271, m RNA S.427.902 1560290 at Homo sapiens, c Ole MAG 5742085, m RNA S4O7533 1562943 at Homo sapiens, c Ole MAG 5742629, m RNA S.546998 1562052 at Homo sapiens, c Ole MAG 576.0143, m RNA S.S.45915 1560794 at Homo sapiens, c Ole MAG 6152133, m RNA S.S47728 232975 at Homo sapiens, Similar to carnitine deficiency S.128454 1569453 a at associated gene expressed in Ventricle 1, clone IMAGE: 4837775, mRNA Homo sapiens, Similar to deafness, autosomal S.87734 235365 at dominant 5 homolog (human), clone IMAGE:4551670, mRNA Homo sapiens, Similar to diaphanous homolog 3 S.444351 229097 at (Drosophila), clone IMAGE: 52.77415, mRNA Homo sapiens, Similar to hypothetical protein S.4068.10 1569482 at FLJ20378, clone IMAGE: 5262617, mRNA Homo sapiens, Similar to hypothetical protein S.252866 1568876 a. at FLJ21394, clone IMAGE: 4820924, mRNA US 2006/01992.04 A1 Sep. 7, 2006 44

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Homo sapiens, Similar to hypothetical protein 1569680 at FLJ21463, clone IMAGE: 4288701, mRNA Homo sapiens, Similar to hypothetical protein 224752 at MGC10526, clone IMAGE: 4133906, mRNA Homo sapiens, Similar to likely ortholog of yeast S.397886 1570503 at ARV1, clone IMAGE: 4576306, mRNA Homo sapiens, Similar to likely ortholog of yeast 213929 at ARV1, clone IMAGE: 4733238, mRNA Homo sapiens, Similar to Rho-associated, coiled S.1782O 213044 at coil containing protein kinase 1, clone MAGE: 5269982, mRNA Homo sapiens, Similar to unnamed HERV-H S.S15223 227919 at protein, clone IMAGE: 3996.038, mRNA -inducible, endoplasmic reticulum HERPUD1 S.146393 217168 s at stress-inducible, ubiquitin-like domain member 1 homolog of yeast INO80 NO8O S.292949 229356 X at homolog of yeast TIM14 TIM14 S.2306O1 225.358 a homolog of yeast TIM14 TIM14 S.2306O1 225359 a HOM-TES-103 tumor antigen-like HOM S.15243 36030 at TES-103 hook homolog 1 (Drosophila) HOOK1 S.378836 219976 a hook homolog 3 (Drosophila) HOOK3 S.162852 235114 X at hook homolog 3 (Drosophila) i? hook homolog 3 HOOK3 S.162852 224359 s at (Drosophila) host cell factor C2 HCFC2 S.S.06S58 HP S.142442 224,592 x at BP74 RAS-like suppressor HRASLS S.36761 -rev 107-like protein 5 HRLPS S.410316 -rev 107-like protein 5 HRLPS S.410316 S1 binding protein HAX1 S.199625 SPCO09 protein HSPCOO9 S.16059 SPCO38 protein LOCS1123 S.374485 SPC049 protein SPCO49 S.371722 SPC103 S.317051 1557817 a. at SPC103 S.317051 1557818. X at SPC128 protein PC128 S.90527 21893.6 s at HSPC128 protein PC128 S.90527 222792 s at HSPC135 protein PC135 S.1274.96 221046 s at HSPC163 protein PC163 S.445890 223993 s at HSPC182 protein PC182 S.30O26 223051 a human immunodeficiency virus type I enhancer HIVEP1 S.S49037 204512 a binding protein 1 uman immunodeficiency virus type I enhancer HIVEP3 244764 a inding protein 3 untingtin interacting protein 2 HIP2 202347 s at untingtin interacting protein B HYPE S.S17941 215038 s at Huntingtin interacting protein B HYPE S.S17941 241458 a untingtin interacting protein E HYPE S.549110 219910 a untingtin interacting protein K HYPK S.S11978 218680 x at hyaluronan and proteoglycan link protein 3 HAPLN3 S.44753O 227262 a hyaluronan binding protein 4 HABP4 S.494567 2098.18 s at yaluronan synthase 2 HAS2 S.159226 206432 a Hyaluronan-mediated motility receptor (RHAMM) HMMR S.72SSO 1557029 at hyaluronan-mediated motility receptor (RHAMM) HMMR S.72SSO 207165 a hydroxyacyl-Coenzyme A dehydrogenase 3 HADHB S.515848 2010.07 a ketoacyl-Coenzyme A thiolase enoyl-Coenzyme A hydratase (trifunctional protein), beta Subunit hydroxysteroid (17-beta) dehydrogenase 12 HSD17B12 S.132S13 217869 a hypermethylated in cancer 2 HIC2 S.517434 212964 a Hyperparathyroidism 2 (with jaw tumor) HRPT2 S.378996 222320 a Hypothetical 55.1 kDa protein F09G8.5 in LOC220074 S.317243 217706 a chromosome III Hypothetical 55.1 kDa protein F09G8.5 in LOC220074 S.317243 226717 a chromosome III hypothetical BC042079 locus LOC474358 237425 a. Hypothetical gene LOC130063 S.437426 244728 a hypothetical gene LOC132870 LOC132870 S.122O53 237769 a Hypothetical gene LOC133874 S.551577 1569417 at hypothetical gene LOC133874 LOC133874 S.551577 237956 S at US 2006/01992.04 A1 Sep. 7, 2006 45

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Hypothetical gene Supported by AF086559: S.367856 233399 x at 5734 Hypothetical gene Supported by AF275804 S.237396 238,022 at hypothetical gene supported by AK055666: FLJ31104 S.482141 1557466 at BCO3 9324 hypothetical gene supported by AKO75484; LOC339804 S.140617 1568658 at BCO14578 hypothetical gene supported by AKO75564: S.27373 51158 at BCO6 Hypo hetical gene Supported by AK091527 S4O7087 242853 at Hypo hetical gene Supported by AK091718 S.446271 226635 at Hypo hetical gene Supported by AKO92637 S.220931 237484 at hypothetical gene supported by AKO93266 LOC400238 S.131037 1557657 a. at Hypo hetical gene Supported by AK093334: LOC2S5326 S.314437 2391.51 at AL83 3330; BC020871; BCO32492 // Homo S.4995.34 Sapiens Similar to ARF GTPase-activating protein, S.531181 clone MAGE: 5245118, mRNA / Hypothetical protein LOC255326 hetical gene supported by AK094796 S.297988 230433 a hetical gene Supported by AKO94957 S.131718 244564 a hetical gene Supported by AKO94963 S.381996 1561389 at hetical gene supported by AK097381: S.S31627 156.2348 at BCO40 866 hetical gene supported by AK123449; LOC4O115S 244395 a BX64 014 hypothetical gene Supported by AK123449; BX641014 FLJ41455 hypo hetical gene supported by AK124699 FLJ42709 S.171132 229014 a hypo hetical gene supported by AK128660 LOC4OOS66 S.4996O7 229238 a hypo hetical gene supported by AL449243 LOC91689 S.306.083 225794 S at Hypo hetical gene Supported by AL713796 S.3896.38 225,046 a Hypo hetical gene Supported by BC013438 LOC375295 S.126OO7 234826 a hypo hetical gene supported by BCO15790; LOC400573 S.306721 23.6001 a BCO)4 1634 Hypo hetical gene Supported by BC017229 S.102276 235938 a Hypo hetical gene Supported by BC028.186 S.3856SO 1557754 at hypo hetical gene supported by BCO29568 MGC39584 S.130535 240814 a Hypo hetical gene Supported by BC029568 MGC39584 S.130535 242822 a hypo hetical gene supported by BC032913; LOC389023 S.97540 236351 a BCO)4 8425 hypo hetical gene supported by BC032955 LOC4O1530 S.S21524 1570388 a. at hypo hetical gene supported by BC032955 f// LOC4O1530 S.S21524 1556378 a. at hypo hetical gene supported by AK127288; AY34 3901 LOC440896 hypo hetical gene supported by BC033316 fif LOC4OO742 S.465825 1556.195 a. at hypo hetical gene supported by BC033316 LOC440572 hypo hetical gene supported by BC037858 LOC44O117 S.127100 240268 a hypo hetical gene supported by BC039313 LOC284861 S.546531 233338 a hypo hetical gene supported by BC040576 LOC4OO920 S.434698 239558 a Hypo hetical gene Supported by BC042734 S.434230 1568660 a. at hypo hetical gene supported by BC044741 LOC38.7872 S.434392 244429 a hypo hetical gene supported by BX248251 LOC387978 S.92SS6 243061 a Hypo hetical gene Supported by BX647608 S.411391 232113 a hypo hetical gene supported by NM 173604 LOC4399.19 S.166754 1553614 a at hypo hetical gene supported by NM 173604 LOC4399.19 S.166754 241953 a Hypo hetical LOC 441046 S.S18857 213251 a hypo hetical LOC129881 LOC129881 S.3701 11 236909 a hypo hetical LOC131076 LOC131076 S.220594 241943 a hypo hetical LOC149018 LOC149018 S.125785 231363 a Hypo hetical LOC151363 S.350698 237982 a hypo hetical LOC158813 LOC158813 S.98197 231159 a Hypo hetical LOC203413 LOC2O3413 S.97892 1559258 a. at Hypo hetical LOC253.662 S.190267 237343 a hypo hetical LOC283677 LOC283677 S.9761O 240689 a hypo hetical LOC283768 LOC283768 S.169639 222149 x at hypo hetical LOC283768 i? golgi autoantigen, LOC283768 S.169639 213737 X at golgin family member similar to hypothetical protein LOC390S35

LOC44O234 US 2006/01992.04 A1 Sep. 7, 2006 46

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical LOC284.067 LOC284O67 S.252707 231453 at Hypothetical LOC387905 S.147563 1561.221 x at Hypothetical LOC387937 S.458461 217332 at Hypothetical LOC388134 S.33333 225270 at hypothetical LOC388381 LOC388381 S.25O182 244316 at Hypothetical LOC388397 S.S28473 227227 at Hypothetical LOC388572 S.S34673 231886 at Hypothetical LOC388650 LOC3886SO S.180946 213689 x at hypothetical LOC388650 LOC3886SO S.180946 216044 x at hypothetical LOC388684 LOC388684 S.263424 244843 x at Hypothetical LOC388727 S.23459 1556274 at hypothetical LOC388727 LOC388,727 S.23459 231233 at hypothetical LOC388.882 LOC388.882 S.126178 1554940 a. at hypothetical LOC389048 LOC389.048 S.S46579 242881 X at hypothetical LOC389177 FLJ23172 S.30688S 217016 x at bothetical LOC389232 S.126428 237758 at l bothetical LOC389440 LOC38944O S.32804 230487 at l bothetical LOC389624 LOC389624 S.1298OO 244135 at ical LOC389634 S.491073 1560001 at bothetical LOC389715 LOC38971S S.S22093 216084 at bothetical LOC389715 LOC38971S S.S22093 241690 at bothetical LOC399933 S.SO3429 228612 at ny ical LOC400236 LOC400236 227887 at bothetical LOC400590 LOC4OO590 S.406,166 241910 x at bothetical LOC40O843 LOC40O843 HS.S215 225860 at ical LOC4O1022 LOC4O1022 S.98661 242042 s at bothetical LOC4O1074 LOC4O1074 S.S285.40 1559826 a. at bothetical LOC4O1131 S.45828S 1566144 at ical LOC4.01131 S.45828S 1566146 x at bothetical LOC4O2532 S.4.18231 243009 a bothetical LOC4O2563 S.489(O28 236282 a ical LOC79954 FLJ14O75 S.2224.94 222684 S at bothetical LOC83640 MGC2560 S.80624 22521.0 s at bothetical locus FLJ25758 FLJ25758 S.36793O 1554286 at bothetical locus FLJ35487 FLJ35487 S.4O7054 1563743 at hypothetical locus LOC494558 LOC494558 S.130722 236071 a Hypothetical protein S.369455 1560818 at Hypothetical protein S.369455 1560819 a. at Hypothetical protein S.369455 231440 a hypothetical protein A-211C6.1 LOCS7149 S.185489 203897 a Hypothetical protein BC001096 LOC92689 S476517 213455 a. hypothetical protein BC004360 LOC87769 S.350868 232422 a hypothetical protein BC007899 LOC148898 S.61884 229086 a hypothetical protein BC008207 LOC92345 S.332844 244828 x at hypothetical protein BC008322 MGC15763 S.4756O2 227686 a hypothetical protein BC009467 LOC158960 S.111407 1558685 a. at hypothetical protein BC009514 LOC127253 S.3484.11 227141 a hypothetical protein BC009518 LOC90799 S.S15009 225705 a hypothetical protein BC011880 LOC113444 S.27160 225404 a hypothetical protein BC011880 LOC113444 S.27160 2395.10 a hypothetical protein BCO15148 LOC93O81 S.398111 213346 a hypothetical protein BC017169 LOC911.37 S.75639 212833 a hypothetical protein BC019238 LOC12O379 S.42O662 235062 a hypothetical protein C8orf) LOC157740 239877 a hypothetical protein DJ328E19.C1.1 /// DJ328E1 S.S15947 212854 x at hypothetical protein FLJ20719 ft AG1 protein 9.C1.1 FLJ2O719 AG1 hypothetical protein DJ328E19.C1.1 /// DJ328E1 S.546664 226740 x at hypothetical protein FLJ20719 ft hypothetical 9.C1.1 protein LOC200030 fill hypothetical protein FLJ2O719 MGC8902 / AG1 protein / hypothetical LOC44O675 LOC2OOO3O

MGC8902 AG1 hypothetical protein DJ971N18.2 HS.169358 201580 s at hypothetical protein DKFZp313A2432 HS.349096 226278 at hypothetical protein DKFZp434F142 HS.307081 224123 at US 2006/01992.04 A1 Sep. 7, 2006 47

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein DKFZp434G156 NAG6 HS.S211.78 226972 s at hypothetical protein DKFZp434HO115 DKFZP434HO115 HS.2O1134 223924 a hypothetical protein DKFZP434IO714 DKFZP434O714 HS142307 231954 a hypothetical protein DKFZp434K191 DKFZ434K191 HS.318898 1557633 at hypothetical protein DKFZp434L142 DKFZ434L142 HS.323583 223204 a hypothetical protein DKFZp434M202 DKFZ434M2O2 HS.387671 231371 a hypothetical protein DKFZp434O0320 DKFZ434OO32O Hs.194995 234925 a. hypothetical protein DKFZp434P055 DKFZ434POSS HS.132519 232398 a Hypothetical protein DKFZp547A023 DKFZS47AO23 HS.485899 226000 a Hypothetical protein DKFZp547B1713 DKFZS47B1713 HS.S49239 240803 a hypothetical protein DKFZp547E052 DKFZS47EOS2 HS.471514 2331.64 x a Hypothetical protein DKFZp547K1113 DKFZS47K1113 HS.459311 213658 a hypothetical protein DKFZp564D172 DKFZPS64D172 HS.127788 212936 a Hypothetical protein DKFZp564IO422 DKFZPS64O422 HS.245798 23O380 a hypothetical protein DKFZp564KO822 fif DKFZPS64KO822 HS.488.307 208091 s a hypothetical protein DKFZp564KO822 hypothetical protein DKFZp566M1046 DKFZPS66M1046 HSSO1793 223637 S a Hypothetical protein DKFZp566M114 DKFZPS66M114 HS.146.162 235143 a Hypothetical protein DKFZp566NO34 DKFZPS66NO34 HS.3694.71 217713 x a Hypothetical protein DKFZp667M2411 DKFZ667M2411 HS.462684 23.0099 a hypothetical protein DKFZp727G131 DKFZ727G131 HS.S46S2O 238609 a hypothetical protein DKFZp761I2123 DKFZ7612123 HS.77978 54970 at hypothetical protein DKFZp762F0713 DKFZ762FOf13 HS.416214 242592 a hypothetical protein DKFZp779O175 DKFZb779O175 HS.124.047 238952 x a hypothetical protein ET ET HS.4641 66 221192 x a hypothetical protein ET ET HS.4641 66 223242 S a hypothetical protein FLJ10081 FLJ10081 HS.516341 224318 s a hypothetical protein FLJ10094 FLJ10094 HS.128258 2195O1 at Hypothetical protein FLJ10156 FLJ101S6 HS.404323 230076 at hypothetical protein FLJ10159 FLJ101.59 HS.445244 218974 at hypothetical protein FLJ10199 FLJ101.99 HS.4653OS 218815 s a hypothetical protein FLJ10276 FLJ10276 HS.353.454 218004 at hypothetical protein FLJ10357 FLJ10357 HS.3512S 241627 x a hypothetical protein FLJ10385 FLJ10385 HS.437460 44563 at hypothetical protein FLJ10534 FLJ10534 HS.38817O 21815.5 x a hypothetical protein FLJ10534 FLJ10534 HS.38817O 21815.6 s a hypothetical protein FLJ10534 FLJ10534 HS.38817O 221987 s a Hypothetical protein FLJ10618 FLJ10618 HS.144130 201918 at Hypothetical protein FLJ10618 FLJ10618 HS.144130 201919 at hypothetical protein FLJ10652 FLJ10652 HS.445129 218614 at Hypothetical protein FLJ10656 P15RS HS.464912 228566 at hypothetical protein FLJ10700 FLJ10700 HS.232197 218464 S at hypothetical protein FLJ10726 FLJ10726 Hs.195060 218314 S at hypothetical protein FLJ10769 FLJ10769 HS.408324 21794.0 s at hypothetical protein FLJ10808 FLJ10808 HS.212774 222600 s at hypothetical protein FLJ10826 FLJ10826 HS.231883 225106 s at hypothetical protein FLJ10901 FLJ10901 HS.S18997 219010 a hypothetical protein FLJ10979 fill hypothetical FLJ10979 HS.461819 221707 s at protein FLJ10979 hypothetical protein FLJ10996 FLJ10996 HS.107845 219774 a Hypothetical protein FLJ11000 FLJ11OOO HS.S21215 243465 a hypothetical protein FLJ11011 FLJ11011 HS.492O31 1562458 at Hypothetical protein FLJ11016 FLJ11016 HS.139053 243673 a hypothetical protein FLJ11029 FLJ11029 HS.274448 219392 x at hypothetical protein FLJ11029 FLJ11029 HS.274448 232215 x at Hypothetical protein FLJ11155 FLJ11155 Hs.176227 1562608 at hypothetical protein FLJ11236 FLJ11236 2284.33 a hypothetical protein FLJ11280 FLJ11280 HS.3346 226062 x at hypothetical protein FLJ11301 FLJ11301 HS.S18SOS 221536 s at hypothetical protein FLJ11305 FLJ1130S HSSO8769 21994.0 s at hypothetical protein FLJ11795 FLJ11795 HS.436214 22O112 a Hypothetical protein FLJ11795 FLJ11795 HS.436214 240456 a hypothetical protein FLJ11800 FLJ11800 HS.287.456 220575 a hypothetical protein FLJ11848 FLJ11848 HS.S2SO17 218957 s at hypothetical protein FLJ11850 FLJ11850 HS.7966 222941 a Hypothetical protein FLJ11996 FLJ11996 HS.131173 242664 a hypothetical protein FLJ12118 FLJ12118 HSSO872S 218153 a hypothetical protein FLJ12118 FLJ12118 HSSO872S 231023 a hypothetical protein FLJ12151 FLJ12151 215373 X at hypothetical protein FLJ12355 FLJ12355 HS287S21 220465 a hypothetical protein FLJ12476 FLJ12476 HS.444535 2398.13 a US 2006/01992.04 A1 Sep. 7, 2006 48

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein FLJ12505 LJ12SOS S.96885 1555092 at hypothetical protein FLJ12666 LJ12666 S.293.563 2224.58 s at hypothetical protein FLJ12671 fill hypothetical L12671 S.3O1904 208114 s at protein FLJ12671 hypothetical protein FLJ13089 LJ13O89 S.530941 236816 at hypothetical protein FLJ13236 LJ13236 S.170298 244193 at hypothetical protein FLJ13273 LJ13273 S.161429 1554518 at hypothetical protein FLJ13456 3456 S.47628O 225350 S at hypothetical protein FLJ13511 l 3 S.S28.701 44702 at Hypothetical protein FLJ13611 LJ13611 S.4823O1 234788 x at Hypothetical protein FLJ13710 LJ13710 S.387.057 222835 at hypothetical protein FLJ13840 LJ13840 S.1235.15 220283 at hypothetical protein FLJ13984 LJ13984 HS.1351.46 1554667 s at hypothetical protein FLJ14001 L14001 S.479612 238983 at hypothetical protein FLJ14154 L14154 HS.513296 218661 at hypothetical protein FLJ14154 L14154 HS.513296 45526 g at hypothetical protein FLJ14346 LJ14346 S.469925 220720 x a hypothetical protein FLJ14451 L14451 S.528696 227430 at hypothetical protein FLJ14624 LJ14624 HS190983 225666 at hypothetical protein FLJ14721 L14721 S.144655 226487 at hypothetical protein FLJ14775 LJ14775 S.1O3SSS 225319 s a hypothetical protein FLJ14904 LJ14904 HS.18O191 2294.75 at hypothetical protein FLJ14966 LJ14966 S.1281.96 243611 at hypothetical protein FLJ20152 LJ2O152 S.481704 218532 s a hypothetical protein FLJ20232 LJ2O232 S.148677 204593 s a hypothetical protein FLJ20232 LJ2O232 S.148677 221516 s a hypothetical protein FLJ20291 LJ2O291 S.406223 218655 s a hypothetical protein FLJ20294 LJ2O294 HS.546404 52731 at hypothetical protein FLJ20308 LJ2O3O8 S.462392 1553101 a. at hypothetical protein FLJ20308 LJ2O3O8 S.462392 234302 s a Hypothetical protein FLJ20309 20309 S.471205 227837 a hypothetical protein 20323 fill hypothetical LJ2O323 S.S2O215 211724 X a protein FLJ20323 hypothetical protein FLJ20340 AX S.272794 207734 a hypothetical protein FLJ20345 S.408,843 1555820 a. at hypothetical protein FLJ20366 S.390.738 218692 a hypothetical protein FLJ20399 S.534460 47105 at hypothetical protein FLJ20425 S.425427 2234-13 s at Hypothetical protein FLJ20444 HS.459.704 1557584 at hypothetical protein FLJ20449 S.124519 22O129 a hypothetical protein FLJ20531 S.377705 220661 s at Hypothetical protein FLJ20533 S.1066SO 226083 a hypothetical protein FLJ20558 S.413123 219128 a hypothetical protein FLJ20604 S S.SS781 219133 a hypothetical protein FLJ20618 S.120446 222244 S at hypothetical protein FLJ20674 HS.187624 22O137 a Hypothetical protein FLJ20701 S.4O9352 1559910 at hypothetical protein FLJ20719 ft hypothetical S.546664 201103 X at protein LOC200030 fill hypothetical protein MGC8902 / AG1 protein / hypothetical

LOC44O675 hypothetical protein FLJ20719 ft hypothetical FL2O719 HS.546664 213612 x at protein MGC8902 AG1 protein i? hypothetical LOC44O675 MGC8902 AG1

LOC44O675 hypothetical protein FLJ20772 FLJ2O772 HS.992S 219299 at hypothetical protein FLJ21106 FL21106 HS.445817 219980 at hypothetical protein FLJ21168 FL211.68 HS.248O8 204665 at hypothetical protein FLJ21272 FL21272 220467 at hypothetical protein FLJ21415 FL21415 HS.S28681 2188.67 s at hypothetical protein FLJ21616 FL21616 HS.194225 219269 at Hypothetical protein FLJ21742 FL21742 HS.306809 232730 at hypothetical protein FLJ21918 FL21918 HS.436585 219395 at Hypothetical protein FLJ21924 FL21924 HS.369368 244188 at hypothetical protein FLJ22028 FLJ22O28 HS.546437 219802 at US 2006/01992.04 A1 Sep. 7, 2006 49

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein FLJ22318 L22318 S.519804 218262 a hypothetical protein FLJ22531 LJ22531 S.292088 238,593 a hypothetical protein FLJ22639 22639 S.351445 220399 a hypothetical protein FLJ22662 LJ22662 HS.131933 218454 a Hypothetical protein FLJ22662 LJ22662 31933 236422 a hypothetical protein FLJ23129 LJ23129 220769 s at hypothetical protein FLJ23191 23.191 219747 a hypothetical protein FLJ23323 LJ23323 1554082 a. at hypothetical protein FLJ23323 LJ23323 218754 a hypothetical protein FLJ23441 LU23441 219217 a hypothetical protein FLJ23518 23S18 223300 s at hypothetical protein FLJ23598 LJ23598 220390 a hypothetical protein FLJ23790 LJ23790 226294 x at hypothetical protein FLJ23825 LJ238.25 1555866 a. at hypothetical protein FLJ23861 LJ23861 22 9 3 4 1554791 a. at hypothetical protein FLJ23861 LJ23861 215046 a hypothetical protein FLJ23861 LJ23861 231252 a hypothetical protein FLJ23878 23878 1553315 at hypothetical protein FLJ23878 23878 1554074 S at Hypothetical protein FLJ25006 LJ2SOO6 244547 a hypothetical protein FLJ25059 LT25059 229025 s at hypothetical protein FLJ25168 LJ251.68 1553400 a. at hypothetical protein FLJ25333 LJ2S333 240065 a hypothetical protein FLJ25371 LT253.71 1553.838 at hypothetical protein FLJ25555 LJ25555 227720 a hypothetical protein FLJ25660 LJ2S660 HS.128069 242259 a hypothetical protein FLJ25770 LJ25770 HS.S2968O 243875 a hypothetical protein FLJ25955 LJ25955 HS.424,594 242162 a hypothetical protein FLJ30430 LJ3O430 1552942 at hypothetical protein FLJ30525 LJ30525 HS.7962 225841 a Hypothetical protein FLJ31153 LJ31153 S.514179 240529 a hypothetical protein FLJ31295 LJ31295 S.23492 226509 a hypothetical protein FLJ31340 LJ31340 S.2O8093 244317 a Hypothetical protein FLJ31810 LJ31810 S.145642 232720 a Hypothetical protein FLJ31951 LJ31951 S.349306 236322 a hypothetical protein FLJ31978 LJ31978 S.12381 22977O a hypothetical protein FLJ32115 LJ32115 S.162143 227450 a hypothetical protein FLJ32440 LJ32440 S388.297 226536 a hypothetical protein FLJ32499 LJ32499 S.2747S 226833 a hypothetical protein FLJ32658 LJ32658 S.S11847 240950 s at hypothetical protein FLJ32786 LJ32786 S.149774 244710 a hypothetical protein FLJ32796 LJ32796 S.129293 1552384 a at hypothetical protein FLJ32915 LJ32915 S.981.33 227687 a hypothetical protein FLJ32926 LJ32926 S.112645 233157 X at hypothetical protein FLJ32940 KFZp686H1423 S.496400 1552870 s at hypothetical protein FLJ32942 LJ32942 S.524476 227711 a hypothetical protein FLJ32949 LJ32949 S.533644 238784 a hypothetical protein FLJ32954 LJ32954 HS.S32901 1553232 at hypothetical protein FLJ32978 LJ32978 S.975.27 1553373 at Hypothetical protein FLJ33708 LJ33708 S.17OO81 242399 a hypothetical protein FLJ34443 LJ34443 S.26410 228318 s at hypothetical protein FLJ34658 LJ34658 S.254699 235904 a hypothetical protein FLJ34969 LJ34969 S.91085 226965 a. hypothetical protein FLJ35382 LJ3538.2 S.520192 244103 a hypothetical protein FLJ35390 LJ35390 S.448456 1564207 at hypothetical protein FLJ35630 LJ35630 S.400698 229603 a hypothetical protein FLJ35802 LJ358O2 S.246284 1552587 at hypothetical protein FLJ35867 LJ35867 S.4.18287 226562 a hypothetical protein FLJ36144 LJ36144 HS.372394 1560790 at Hypothetical protein FLJ36166 LJ36166 S.148768 215143 a hypothetical protein FLJ36754 LJ36754 HS.S19343 1553581 s at hypothetical protein FLJ38281 LJ38281 S.306478 1570366 x at hypothetical protein FLJ38288 LJ38288 S.10954O 2286.52 a Hypothetical protein FLJ38348 LJ38348 S.S46523 213294 a Hypothetical protein FLJ38374 LJ38374 HS.44906S 216053 x at hypothetical protein FLJ38964 LJ38964 HS.444911 235699 a hypothetical protein FLJ38973 LJ38973 S.47 1040 227973 a hypothetical protein FLJ38973 LJ38973 S.47 1040 238974 a hypothetical protein FLJ38984 LJ38984 HS.112023 212791 a hypothetical protein FLJ39599 LJ39599 S.4O1798 1559167 x at hypothetical protein FLJ40176 LJ4O176 S.368.382 1561846 s at US 2006/01992.04 A1 Sep. 7, 2006 50

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein FLJ40201 FLJ4O2O1 S.376O18 1557016 a. at hypothetical protein FLJ40235 FLJ4O235 S.381087 1553887 at hypothetical protein FLJ40243 FLJ40243 S.97714 240411 at hypothetical protein FLJ40244 FLJ40244 HS.434123 233462 at hypothetical protein FLJ40342 FLJ40342 S.463303 1553626 a. at hypothetical protein FLJ40342 FLJ40342 S.463303 1553627 S at hypothetical protein FLJ40342 FLJ40342 S.463303 1554772 at Hypothetical protein FLJ40342 FLJ40342 S.463303 1558,854 a at Hypothetical protein FLJ40342 FLJ40342 S.463303 231651 a hypothetical protein FLJ40427 FLJ40427 S.2O1378 243802 a hypothetical protein FLJ40432 FLJ40432 S.471234 228810 a hypothetical protein FLJ40473 FLJ40473 155.8987 at hypothetical protein FLJ90575 FLJ90575 S.381181 238,682 a hypothetical protein FLJ90709 FLJ90709 S.128696 243709 a hypothetical protein H4 H4 S.S18265 212010 s at hypothetical protein H4 H4 S.S18265 213548 s at Hypothetical protein H41 H4 S.S18265 2287.46 s at hypothetical protein HS747E2A HS747E2A HSSO891 2068.39 a hypothetical protein HSPCO16 HSPCO16 S.546394 221791 s at hypothetical protein HSPC129 HSPC129 S.497967 1555106 a at hypothetical protein HSPC148 HSPC148 S.SO3597 223067 a hypothetical protein HSPC196 HSPC196 S.40653O 223113 a hypothetical protein HSPC268 HSPC268 S.370475 226780 s at hypothetical protein KIAA1434 KIAA1434 S.472040 224826 a hypothetical protein LOC115749 LOC115749 S.287OO 236840 a hypothetical protein LOC120376 LOC12O376 S.31409 228338 a Hypothetical protein LOC123722 LOC123722 S.S13091 228930 a. Hypothetical protein LOC124512 LOC124512 S.746SS 225808 a hypothetical protein LOC128344 LOC128344 228100 a hypothetical protein LOC144438 LOC144438 225493 a hypothetical protein LOC144571 LOC144571 1564139 at hypothetical protein LOC144997 LOC144997 227289 a Hypothetical protein LOC146174 LOC146174 S.549248 230296 a hypothetical protein LOC147004 LOC147004 S.434122 1564203 at hypothetical protein LOC148145 LOC148,145 S.112651 1557.550 at hypothetical protein LOC148189 LOC148,189 S.190O90 235191 a hypothetical protein LOC148203 LOC1482O3 S.35953S 2297.00 a Hypothetical protein LOC1494.01 LOC1494O1 S.191475 242232 a hypothetical protein LOC149832 LOC149832 S.126857 228456 S at hypothetical protein LOC149837 LOC149837 S.123.609 229992 a hypothetical protein LOC150271 LOC150271 228.658 a hypothetical protein LOC150297 LOC150297 S.426551 1555990 at hypothetical protein LOC150297 LOC150297 S.426551 1555.991 S. at hypothetical protein LOC151121 LOC151121 S.S31687 1560750 at hypothetical protein LOC151300 LOC151300 S.42O716 239506 s at hypothetical protein LOC151300 LOC151300 S.42O716 239507 a hypothetical protein LOC151658 LOC151658 S.159043 238283 a Hypothetical protein LOC152485 LOC152485 S.133916 228.046 a Hypothetical protein LOC152485 LOC152485 S.133916 231902 a Hypothetical protein LOC152485 LOC152485 S.133916 243618 S at Hypothetical protein LOC152519 LOC152519 S.134190 1562792 at hypothetical protein LOC153546 LOC153S46 236124 a hypothetical protein LOC153561 LOC153561 S.S4SS78 213089 a hypothetical protein LOC153561 LOC153561 S.S4SS78 232889 a hypothetical protein LOC157693 LOC157693 S.S21342 1559140 at hypothetical protein LOC157697 LOC157697 S.128130 1563315 S. at hypothetical protein LOC157697 LOC157697 S.128130 227017 a Hypothetical protein LOC1581 60 LOC1581 60 S.380900 244075 a hypothetical protein LOC161527 LOC161527 S.S34573 213212 x at hypothetical protein LOC162427 LOC162427 S.463O79 212697 a hypothetical protein LOC169355 LOC169355 S.122077 1568.638 a. at hypothetical protein LOC196913 LOC1969.13 S.406934 1564785 at hypothetical protein LOC199899 LOC199899 S.116210 242284 a hypothetical protein LOC200030 LOC2OOO3O S.S15837 2294.47 x at hypothetical protein LOC200030 ft hypothetical LOC2OOO3O S.S15947 242191 a LOC400781 / AG1 protein LOC4OO781

AG1 hypothetical protein LOC200205 LOC2002OS HS.237017 231983 at hypothetical protein LOC201243 LOC2O1243 HS.380704 240082 s at US 2006/01992.04 A1 Sep. 7, 2006 51

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein LOC201895 LOC2O1895 S.2O5952 224990 at hypothetical protein LOC202051 LOC2O2OS1 S.373612 1558641 at hypothetical protein LOC202051 LOC2O2OS1 S.373612 238,027 at hypothetical protein LOC220930 LOC220930 S.372654 229090 at hypothetical protein LOC221122 LOC221122 S.SS1656 1560279 a. at hypothetical protein LOC221442 LOC221442 S.374O76 236832 at hypothetical protein LOC221810 LOC221810 S.363292 221910 at hypothetical protein LOC222070 LOC222070 51774 S at hypothetical protein LOC222070 LOC222070 58900 at hypothetical protein LOC222967 fill hypothetical LOC222967 S.510465 1557417 s at protein LOC285927 LOC28S927 Hypothetical protein LOC254128 LOC2S4128 S.S35621 1557059 at hypothetical protein LOC254128 LOC2S4128 S.S35621 235132 a hypothetical protein LOC255326 LOC2S5326 S.314437 231106 a hypothetical protein LOC255330 LOC2SS330 S.145435 244681 a hypothetical protein LOC255480 LOC2SS.480 S.363O81 239919 a hypothetical protein LOC255783 LOC255783 S.128690 227325 a. Hypothetical protein LOC256021 LOC2S6021 S.209203 2435.09 a hypothetical protein LOC256273 LOC2S6273 S.99626 2294.66 a hypothetical protein LOC257407 LOC2574O7 S.S26596 556464 a at hypothetical protein LOC282980 LOC28298O 564209 at hypothetical protein LOC283377 LOC283377 S.128676 225616 a hypothetical protein LOC283403 LOC2834O3 S.14288O 560277 a. at hypothetical protein LOC2834.04 LOC2834.04 S.SSO 633 558195 at hypothetical protein LOC283480 LOC283480 S.5493OO hypothetical protein LOC283481 LOC283481 hypothetical protein LOC283666 LOC2836.66 S.512943 hypothetical protein LOC283680 LOC28368O S.22O864 hypothetical protein LOC283854 LOC283854 S.266768 hypothetical protein LOC283914 LOC283914 S385772 Hypothetical protein LOC283970 LOC28.3970 S.165328 Hypothetical protein LOC284.009 LOC284.009 S.2241.87 hypothetical protein LOC284.058 LOC284.058 S.405514 hypothetical protein LOC284.058 LOC284.058 S.405514 hypothetical protein LOC284242 LOC284242 560250 S at hypothetical protein LOC284267 LOC284267 S.514843 228453 a hypothetical protein LOC284356 LOC284356 S.S47S30 555842 at Hypothetical protein LOC2843.71 LOC2843.71 S.178471 229279 a hypothetical protein LOC284591 LOC284591 S.1331.83 55.7055 s at Hypothetical protein LOC284701 // CDNA LOC2847O1 S.S12176 231821 x at FLJ41452 fis, clone BRSTN2O10363 1// S.S30543 Hypothetical gene Supported by AK128780 S.546653 hypothetical protein LOC284701 fill hypothetical LOC2847O1 S.546.654 225899 X at gene Supported by AK128780 i? FLJ45445 protein fit hypothetical gene supported by AKO93729; LOC388312 BX647918 i? similar to hypothetical protein LOC349114 i? hypothetical gene supported by FLJ45445 AKO97080; AL117642; BC047304; BC054485 LOC440470

LOC440740

LOC441OOO hypothetical protein LOC284701 i? hypothetical LOC2847O1 HSS46653 227129 x at gene Supported by AK128780 i? FLJ45445 protein fit hypothetical gene supported by AKO97080; LOC388312 AL117642; BC047304; BC054485 FLJ45445

LOC441OOO hypothetical protein LOC284757 LOC2847S7 HS.126778 236846 at hypothetical protein LOC284837 LOC284837 HS.313689 1563.088 a. at Hypothetical protein LOC284958 LOC284958 HS.4342SO 1560204 at hypothetical protein LOC284958 LOC284958 HS.4342SO 1562020 S at hypothetical protein LOC285.147 LOC285.147 HS.467627 2361.66 at hypothetical protein LOC285148 LOC285148 HS.509314 225908 at hypothetical protein LOC285148 LOC285148 HS.509314 230621 at hypothetical protein LOC285.194 LOC285.194 HS.12O364 1558602 a at hypothetical protein LOC285331 LOC285331 HS.476399 2281.22 at Hypothetical protein LOC285389 LOC28S389 HS.1571 O2 244668 at US 2006/01992.04 A1 Sep. 7, 2006 52

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein LOC285.429 LOC285.429 HS.213307 1562209 at Hypothetical protein LOC2855.05 LOC285.505 HS.S35739 231557 a hypothetical protein LOC285550 LOC285550 HS.39998O 2274.66 a hypothetical protein LOC285636 LOC28S636 HS.298.99 226159 a hypothetical protein LOC285638 LOC28S638 HS.532104 1563489 at hypothetical protein LOC285735 LOC285735 HS.407549 1561691 at hypothetical protein LOC285740 LOC28S740 HS.432656 237614 a hypothetical protein LOC286009 LOC286009 1562664 at hypothetical protein LOC286052 LOC286052 241370 a hypothetical protein LOC286109 LOC286.109 243304 a hypothetical protein LOC28.6114 LOC28.6114 HS.357242 244255 a Hypothetical protein LOC286144 LOC286144 HS.44O643 225600 a hypothetical protein LOC286254 LOC286254 HS.17OO3S 1559765 a. at hypothetical protein LOC338579 LOC338.579 HS.434365 1561225 at hypothetical protein LOC338653 LOC3386S3 1562960 at hypothetical protein LOC338758 LOC338.758 HS.136888 238893 a hypothetical protein LOC339287 LOC339.287 HS.S32786 224765 a hypothetical protein LOC3394.48 LOC3394.48 HS.103939 222000 a hypothetical protein LOC3394.48 LOC3394.48 HS.103939 238010 a Hypothetical protein LOC339524 LOC339524 HS.306423 215039 a hypothetical protein LOC339524 LOC339524 HS.306423 235870 a hypothetical protein LOC339666 LOC339666 HS.S31913 234385 a. hypothetical protein LOC339803 LOC3398O3 HS.2S2433 227941 a hypothetical protein LOC339834 LOC339834 HS.383.008 1569690 at hypothetical protein LOC339894 LOC339894 HS.478OSO 1561723 at hypothetical protein LOC339903 LOC339903 HS.146346 228721 a hypothetical protein LOC339988 LOC339988 HS.434746 1562697 at hypothetical protein LOC339988 LOC339988 HS.434746 1562698 xat hypothetical protein LOC340085 LOC340O85 232455 x at hypothetical protein LOC340239 LOC34O239 HS.S2O877 1557664 at hypothetical protein LOC340529 LOC340529 HS.45032O 15572O3 at hypothetical protein LOC346653 LOC346653 HS.445236 237320 a hypothetical protein LOC348801 LOC3488O1 HS.SSOS66 227181 a hypothetical protein LOC374768 LOC374768 HS.4997O7 240878 a hypothetical protein LOC375035 LOC375035 HS.S46SS7 214838 a hypothetical protein LOC51057 LOC51057 HS.414952 2241.80 x at hypothetical protein LOC51057 LOC51057 HS.414952 231770 x at hypothetical protein LOC51233 LOCS1233 HS.S17466 221108 a hypothetical protein LOC51233 LOCS1233 HS.S17466 237325 a. Hypothetical protein LOC51234 LOCS1234 HS.2SO90S 226741 a hypothetical protein LOC51321 LOCS1321 HS.268122 218167 a hypothetical protein LOC56757 LOC56757 225509 a hypothetical protein LOC57821 LOCS7821 HS.130746 1555112 a. at hypothetical protein LOC57821 LOCS7821 HS.130746 206721 a hypothetical protein LOC901 10 LOC901.10 HS.S47488 226842 a hypothetical protein LOC90321 LOC90321 HS.439662 227284 a hypothetical protein LOC90520 LOC90S2O HS.SS2781 233342 a hypothetical protein LOC91548 LOC91548 HS.367839 234341 x a hypothetical protein LOC92482 LOC92482 HS.192249 213220 a hypothetical protein LOC92912 LOC92912 HS.23O33 224747 a hypothetical protein MAC30 MAC30 HS.19969S 212279 a hypothetical protein MAC30 MAC30 HS.19969S 212281 s a hypothetical protein MAC30 MAC30 HS.19969S 212282 a hypothetical protein MDS025 MDSO2S HS.368866 218288 s a Hypothetical protein MGC10067 MGC1 OO67 HS.190447 2394.89 a hypothetical protein MGC100.67 MGC1 OO67 HS.190447 243916 x a hypothetical protein MGC10198 MGC101.98 HS.133337 225574 a hypothetical protein MGC10850 MGC10850 223707 a hypothetical protein MGC10986 MGC10986 HS-5144O2 242117 a hypothetical protein MGC11324 fill hypothetical MGC11324 HS.991.96 224480 s a protein MGC11324 Hypothetical protein MGC12458 MGC12458 HS.134857 1557674 is at hypothetical protein MGC12760 MGC12760 HS.S22876 1569293 X at hypothetical protein MGC12966 it hypothetical MGC12966 HS.798O 224452 s a protein MGC12966 hypothetical protein MGC12981 MGC12981 HS.1042O3 224946 s a hypothetical protein MGC13008 MGC13008 224132 at Hypothetical protein MGC13057 MGC13057 HS.389.311 232773 at hypothetical protein MGC14128 BJ-TSA-9 HS.3798.21 239586 at hypothetical protein MGC14151 MGC14151 HS.333414 225441 X a US 2006/01992.04 A1 Sep. 7, 2006 53

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein MGC14151 ff hypothetical MGC14151 HS.333414 224.512 s at protein MGC14151 hypothetical protein MGC14156 MGC14156 HS.261.36 224660 a Hypothetical protein MGC14161 MGC14161 HS.368399 240502 a hypothetical protein MGC14425 MGC1442S 1552665 at hypothetical protein MGC14436 MGC14436 HS.33452S 1553811 at hypothetical protein MGC14801 / hypothetical MGC148O1 HS.S23932 224443 a protein MGC14801 hypothetical protein MGC14801 / hypothetical MGC148O1 HS.S23932 224444 S at protein MGC14801 hypothetical protein MGC15882 MGC15882 HS.194610 231514 a hypothetical protein MGC16169 MGC16169 HS.292986 226126 a hypothetical protein MGC16207 MGC162O7 225211 a hypothetical protein MGC17791 MGC17791 HS.465643 227420 a Hypothetical protein MGC19780 MGC1978O HS.408,927 1560533 at hypothetical protein MGC20481 MGC2O481 HS.14652O 1558.648 at hypothetical protein MGC20481 MGC2O481 HS.14652O 225397 a hypothetical protein MGC21416 MGC21416 HS.82719 212340 a hypothetical protein MGC21416 MGC21416 HS.82719 212341 a hypothetical protein MGC21518 MGC21518 HS.3531.63 226565 a hypothetical protein MGC22014 MGC22O14 HS.S16107 235542 a Hypothetical protein MGC22265 MGC22265 HS.374448 556742 at Hypothetical protein MGC22265 fit Similar to MGC22265 HS.374448 213605 S at bA11OH4.2 (similar to membrane protein) HS.482414 hypothetical protein MGC22773 MGC22773 HS.1511.93 5.53674 at hypothetical protein MGC23401 MGC234O1 HS.S27874 213065 a. hypothetical protein MGC23909 MGC23909 HS.355606 226276 a hypothetical protein MGC24103 MGC24103 232568 a hypothetical protein MGC24132 MGC241.32 HS.1494.87 553689 s at hypothetical protein MGC2574 MGC2S74 HS.4253 203119 a hypothetical protein MGC2654 MGC2654 HS.30638O 218945 a. hypothetical protein MGC26594 MGC26594 HS.97335 554545 at hypothetical protein MGC26733 MGC26733 HS.269977 555,298 a. at hypothetical protein MGC26733 MGC26733 HS.269977 562371 S. at hypothetical protein MGC26856 MGC26856 HS.SS1586 23.8296 a hypothetical protein MGC26989 MGC26989 HS.514662 558,834 S. at hypothetical protein MGC27069 LOC151649 HS.SS2611 552747 a. at hypothetical protein MGC27277 MGC27277 HS.133977 242283 a hypothetical protein MGC2744 MGC2744 HS.317403 222064 S at hypothetical protein MGC2744 MGC2744 HS.317403 238740 a hypothetical protein MGC2747 MGC2747 HS.356467 224712 x at hypothetical protein MGC29463 MGC294.63 HS.483537 227166 a hypothetical protein MGC2963 i? hypothetical MGC2963 HS.30011 221255 s at protein MGC2963 hypothetical protein MGC29875 MGC29875 Hs.1947S4 220251 a hypothetical protein MGC29898 MGC29898 HS.479.298 235259 a hypothetical protein MGC29898 MGC29898 HS.479.298 235260 S at hypothetical protein MGC30208 MGC30208 HS.13S215 229736 a hypothetical protein MGC3123 MGC3123 HS.181391 218419 s at hypothetical protein MGC3234 MGC3234 HS.144468 223.061 a hypothetical protein MGC33212 MGC33212 228.606 a hypothetical protein MGC3329 MGC3329 HS.S.13862 226744 a hypothetical protein MGC33371 MGC33371 HS.2883O4 232048 a hypothetical protein MGC33407 MGC334O7 HS.2092O6 243208 x at hypothetical protein MGC33648 MGC33648 HS.8S950 238465 a hypothetical protein MGC33839 MGC33839 HS.348531 231162 a hypothetical protein MGC33867 MGC33867 HS.S2O094 224708 a hypothetical protein MGC33887 MGC33887 HS.408676 213644 a hypothetical protein MGC33948 MGC33948 HS.367437 1552988 at hypothetical protein MGC34034 MGC34034 HS.1261.65 1552900 a. at hypothetical protein MGC34732 MGC34732 HS.129284 237160 a Hypothetical protein MGC35048 MGC3SO48 HS.460217 216135 a. hypothetical protein MGC35097 MGC35097 Hs.13781 225755 a hypothetical protein MGC35118 MGC3S118 HS.179646 156O184 at hypothetical protein MGC35274 MGC35274 HS-134045 226748 a Hypothetical protein MGC39325 MGC3932S HS.154652 232668 a hypothetical protein MGC39389 HEXIM2 HS.S6382 238,547 a hypothetical protein MGC39518 MGC39518 HS.482656 1554178 a. at hypothetical protein MGC39520 MGC39520 HS.549268 1552526 at hypothetical protein MGC39606 MGC39606 HS.374414 2279.09 a hypothetical protein MGC39633 MGC396.33 HS.4361.21 235208 a US 2006/01992.04 A1 Sep. 7, 2006 54

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID hypothetical protein MGC40178 MGC4O178 S.124463 243884 a Hypothetical protein MGC40222 MGC4O222 S.173337 244829 a hypothetical protein MGC40405 MGC40405 S.18564 226332 a Hypothetical protein MGC40405 MGC40405 S.18564 233204 a Hypothetical protein MGC40405 MGC40405 S.18564 233867 a hypothetical protein MGC42174 MGC42174 S.471637 238602 a hypothetical protein MGC42630 MGC42630 S.31240 227563 a hypothetical protein MGC4268 MGC4268 S.546449 223297 a hypothetical protein MGC42718 MGC42718 S.98660 231266 a hypothetical protein MGC4278 MGC4278 220352 x at hypothetical protein MGC4308 i? hypothetical MGC4308 HS.SS1567 224.523 s at protein MGC4308 hypothetical protein MGC43690 MGC43690 HS.131903 235298 a hypothetical protein MGC45477 MGC4S477 HS.S1101S 1554250 s at hypothetical protein MGC45731 MGC45731 HS.3811 OS 227080 a hypothetical protein MGC46336 MGC46336 HS.381893 1555078 at hypothetical protein MGC46336 MGC46336 HS.381893 1564362 x at Hypothetical protein MGC4692 MGC4692 HS.442634 222622 a hypothetical protein MGC4771 MGC4771 210723 x a hypothetical protein MGC48972 MGC48972 HS.101.007 239648 a hypothetical protein MGC5139 MGCS139 HS.1276.10 202365 a Hypothetical protein MGC5178 MGCS178 HS.460558 209836 x a hypothetical protein MGC52057 MGC52057 HS.21929 239028 a hypothetical protein MGC5242 MGCS242 HS.S21213 220949 s a hypothetical protein MGC5306 MGCS306 Hs.355750 218750 a hypothetical protein MGC5306 MGCS306 Hs.355750 222728 s a hypothetical protein MGC5590 MGCS590 220931 a hypothetical protein MGC8721 MGC8721 HS.S21487 200847 s a hypothetical protein MGC9913 MGC9913 HS.231.33 244740 a hypothetical protein MGC9913 MGC9913 HS.231.33 244741 s a hypothetical protein PRO1855 PRO1855 S.370927 222231 s a Hypothetical protein PRO2730 PRO2730 S.194110 201934 a hypothetical protein PRO2852 PRO2852 223797 a hypothetical protein RP4-622L5 RP4 S.272.299 22365.6 s a 622LS hypothetical protein TI-227H TI-227H 212337 a hypothetical protein TI-227H TI-227H 212725 s a hypoxia-inducible factor 1, alpha subunit (basic HIF1A S.SO9554 200989 a helix-loop-helix transcription factor) hypoxia-inducible factor prolyl 4-hydroxylase PH-4 S.271224 222125 s a BR domain containing 2 BRDC2 S.148741 228153 a GF-II mRNA-binding protein 2 MP-2 S.353S4 218847 a GF-II mRNA-binding protein 3 MP-3 S.432616 20381.9 s a GF-II mRNA-binding protein 3 MP-3 S.432616 203820 s a L2-inducible T-cell kinase TK S.483938 211339 s a MAGE: 729984 clone, mRNA S.SS3160 1560920 S. at immediate early response 2 ER2 S.5O1629 202081 at immediate early response 3 ER3 S.76095 201631 s a immediate early response 5 ERS S.15725 218611 at mmunoglobulin (CD79A) binding protein 1 GBP1 S.496.267 242337 at immunoglobulin Superfamily, member 3 GSF3 S.17105.7 202421 at immunoglobulin Superfamily, member 4 GSF4 S.370510 209030 S a mmunoglobulin Superfamily, member 4 GSF4 S.370510 232793 at 11 PO11 S.482269 234304 S a importin 7 PO7 S.S23470 200992 at importin 8 PO8 S.SOS136 225.528 at importin 9 PO9 S.497384 217885 at importin 9 PO9 S.497384 225728 at influenza virus NS1A binding protein WNS1ABP S.4971.83 206245 s at Inhibin, alpha NHA S4O7SO6 1569409 x at inhibin, beta C NHBC S.374664 2O7688. S. at inhibitor of DNA binding 2, dominant negative D2 S.180919 201565 s at helix-loop-helix protein inhibitor of DNA binding 2, dominant negative S.180919 201566 x at helix-loop-helix protein fit inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein inhibitor of DNA binding 2, dominant negative S.180919 213931 at helix-loop-helix protein fit inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein inhibitor of DNA binding 4., dominant negative S.5196O1 209291 at helix-loop-helix protein US 2006/01992.04 A1 Sep. 7, 2006 55

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID inhibitor of DNA binding 4., dominant negative S.5196O1 209293 X at helix-loop-helix protein inhibitor of growth family, member 3 NG3 S.489811 205070 at inner membrane protein, mitochondrial (mitofilin) MMT S.148559 200955 at Inner membrane protein, mitochondrial (mitofilin) MMT S.148559 242361 at inorganic pyrophosphatase 2 PPA2 S.480452 220741 s at inositol hexaphosphate kinase 2 HPK2 S.476221 2231.65 s at inositol polyphosphate-1-phosphatase NPP1 S.32309 202794 at inositol polyphosphate-4-phosphatase, type II, NPP4B S.480837 205376 at 105 kDa inositol polyphosphate-4-phosphatase, type II, S.480837 223878 at 105 kDa inositol polyphosphate-5-phosphatase, 40 kDa S.S23360 203006 at insulin receptor S.465744 213792 s at Insulin receptor NSR S.465744 227432 S at insulin receptor Substrate 2 RS2 S.442344 20918.4 S at insulin-degrading enzyme DE S.SOOS46 203328 x at integral membrane glycoprotein-like similar to LOC166994 S.S31427 1558O11 at bA11 OH4.2 (similar to membrane protein) i? similar to bA11OH4.2 (similar to membrane protein) f/ LOC340O89 similar to bA11OH4.2 (similar to membrane protein) LOC441081

LOC441098 integral membrane protein 2B TM2B S.44645O 217732 s at integrin beta 3 binding protein (beta,3-endonexin) TGB3BP S.166539 205176 s at integrin beta 4 binding protein TGB4BP S.534326 210213 s at integrin, alpha 10 TGA10 S.158237 2O6766 at integrin, alpha2b (platelet glycoprotein IIb of TGA2B S.411312 206493 at IIb.IIIa complex, antigen CD41B) integrin, beta 1 (fibronectin receptor, beta TGB1 211945 s at polypeptide, antigen CD29 includes MDF2, MSK12) integrin, beta 3 (platelet glycoprotein IIIa, antigen TGB3 S.218040 216261 a CD61) Integrin, beta-like 1 (with EGF-like repeat domains) TGBL1 S.SO8597 233185 a inter-alpha (globulin) inhibitor H3 TIEH3 S.76716 205755 a. inter-alpha (globulin) inhibitor H4 (plasma TIEH4 S.518OOO 242720 a Kallikrein-sensitive glycoprotein) interferon induced transmembrane protein 1 (9–27) FITM1 S.458414 214022 S at interferon regulatory factor 1 S.436061 202531 a interferon regulatory factor 6 RF6 S.3SS827 202597 a interferon-induced protein with tetratricopeptide FIT3 S.549041 2294.50 a repeats 3 interleukin 1 receptor antagonist S.81134 212657 s at interleukin 13 receptor, alpha 2 S.336O46 206172 a Interleukin 24 S.411311 239122 a Interleukin 4 receptor S.S13457 242743 a interleukin 6 receptor S.135087 226333 a interleukin 6 receptor fit interleukin 6 receptor S.135087 205945 a. interleukin 6 signal transducer (gp130, oncostatin S.S32O82 204864 S at M receptor) interleukin 7 S.536926 206693 a interleukin enhancer binding factor 3, 90 kDa S.465885 211375 s at intersectin 1 (SH3 domain protein) S.160324 35776 at intersectin 2 S.432562 209898 X at intracisternal Aparticle-promoted polypeptide S.15718O 1554740 a. at IQ motif and WD repeats 1 S.435741 217908 s at IQ motif and WD repeats 1 S.435741 232349 x at IQ motif containing F1 S.381854 1552997 a. at IQ motif containing F3 S.2548O8 1555235 S. at IQ motif containing F3 S.2548O8 236871 s at IQ motif containing G S.S18536 221185 S at IQ motif containing GTPase activating protein 1 S.43OSS1 210840 S at IQ motif containing GTPase activating protein 3 S.133294 229538 s at IQ motif containing with AAA domain S.1291.74 238584 at ISL1 transcription factor, LIM homeodomain, (islet S.SOS 206104 at 1) islet cell autoantigen 1, 69 kDa i? islet cell CA1 S.487561 211740 at autoantigen 1, 69 kDa isocitrate dehydrogenase 1 (NADP+), soluble DH1 S.11223 1555037 a. at US 2006/01992.04 A1 Sep. 7, 2006 56

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID isocitrate dehydrogenase 3 (NAD+) alpha DH3A S.250616 202069 s 8. isoleucine-tRNA synthetase ARS S.445403 204744 s 8. soleucine-tRNA synthetase ARS S.445403 239794 at Sopentenyl-diphosphate delta isomerase DI1 S.283652 242255 at itchy homolog E3 ubiquitin protein ligase (mouse) TCH S.472SO9 209744 x a itchy homolog E3 ubiquitin protein ligase (mouse) TCH S.472SO9 217094 S 8. anus kinase 1 (a protein tyrosine kinase) AK1 S.551505 201648 at jumonji domain containing 1A MD1A S.531819 212689 s 8. jumonji domain containing 1C MD1 C S.413416 224933 s 8. jumonji domain containing 1C MD1 C S.413416 228793 at jumonji domain containing 2A MD2A S.155983 203204 s 8. jumonji domain containing 2C MD2C S.157106 214861 at umonji domain containing 2C MD2C S.157106 239285 at umonji, AT rich interactive domain 1A (RBBP2 ARID1A S.76272 202040 S 8. ike) umonji, AT rich interactive domain 1B (RBP2-like) ARID1B S.443650 201548 s 8. umonji, AT rich interactive domain 1B (RBP2-like) ARID1B S.443650 201549 x a umonji, AT rich interactive domain 1B (RBP2-like) ARID1B S.443650 211202 s 8. umonji, AT rich interactive domain 2 ARID2 S.269059 203297 S 8. jumping translocation breakpoint TB S.6396 210434 X a jumping translocation breakpoint TB S.6396 210927 x a jun D proto-oncogene 203752 s 8. junction-mediating and regulatory protein S.482605 24.1985 at junctophilin 1 S.160574 1553533 at KARP-1-binding protein S.S3363S 207719 x a KARP-1-binding protein i? hypothetical protein S.S3363S 1552717 s at MGC26143 karyopherin (importin) beta 1 S.S32793 208974 x a karyopherin (importin) beta 1 S.S32793 213507 S 8. Karyopherin (importin) beta 1 S.S32793 213574 s 8. Karyopherin (importin) beta 1 S.S32793 213803 at karyopherin alpha 1 (importin alpha 5) S.161008 213741 s 8. karyopherin alpha 2 (RAG cohort 1, importin alpha S.1595.57 201088 at karyopherin alpha 2 (RAG cohort 1, importin alpha KP NA. 2 S.1595.57 211762 s 8. ) i? karyopherin alpha 2 (RAG cohort 1, importin alpha 1) karyopherin alpha 3 (importin alpha 4) PNA3 S.S27919 221502 at karyopherin alpha 3 (importin alpha 4) PNA3 S.S27919 221503 s 8. Karyopherin alpha 3 (importin alpha 4) PNA3 S.S27919 233224 at karyopherin alpha 4 (importin alpha 3) PNA4 S.288.193 225268 at Karyopherin alpha 5 (importin alpha 6) PNA5 S.182971 227934 at karyopherin alpha 6 (importin alpha 7) PNA6 S.470588 212101 at karyopherin alpha 6 (importin alpha 7) PNA6 S.470588 212102 s at Karyopherin alpha 6 (importin alpha 7) PNA6 S.470588 226976 at katanin péO (ATPase-containing) subunit A 1 TNA1 S.131838 205526 S. at katanin pé0 subunit A-like 1 TNAL1 S.119672 223790 at Katanin p60 subunit A-like 1 TNAL1 S.119672 243828 at katanin p80 (WD repeat containing) subunit B 1 B1 S.275675 203162 s at KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum E S.520210 200698 at protein retention receptor 2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum K D E R2 S.520210 200700 S at protein retention receptor 2 kelch domain containing 3 S.412468 214383 x at kelchC domain containing 4 S.461688 2321.71 x at kelchC domain containing 5 S.505104 225961 a kelchC repeat and BTB (POZ) domain containing 2 S.372541 212447 a kelchC repeat and BTB (POZ) domain containing 2 S.372541 223584 S at kelchC repeat and BTB (POZ) domain containing 3 S.1O1949 228777 a kelchC repeat and BTB (POZ) domain containing 4 S.44O695 21857O a kelchC repeat and BTB (POZ) domain containing 7 S.63841 223412 a kelchC ankyrin repeat containing cyclin A1 S.SOf290 227582 a interacting protein kelch-like 10 (Drosophila) S.127510 1552425 a. at Kelch-like 11 (Drosophila) S.13268 226883 a kelch-like 12 (Drosophila) S.282878 225068 a kelch-like 18 (Drosophila) S.S17946 212882 a kelch-like 20 (Drosophila) S.49SO3S 204177 s at kelch-like 7 (Drosophila) S.385.861 220238 s at kelch-likeC 7 (Drosophila) S.385.861 220239 a kelch-likeC 7 (Drosophila) S.385.861 223250 a

US 2006/01992.04 A1 Sep. 7, 2006 58

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID AAO907 protein KIAAO907 S.24656 202220 at AA0912 protein Cep 152 S.443OOS 215170 s at AA0912 protein Cep 152 S.443OOS 237129 at AA0934 AA0934 S.432397 1560763 at AA0980 protein AAO980 S.472347 20770S S at AAO998 AAO998 S.200747 214672 at S.200747 215898 at S.200747 243988 at AAO998 KIAA0998 S.200747 208099 X at AAO999 O el S.167451 1554929 at AAO999 O ein S.167451 1563455 at AAO999 O ein S.167451 204157 s at AAO999 O ein S.167451 242920 a OO2 O ein S.443673 203831 a O08 S.S31 O29 222607 s at O12 S.2O2OO1 207305 S at O26 O ein S.368823 213478 a O43 O ein S.387856 21514.6 s at O49 O ein S.415342 213311 s at 052 O ein e 6 4 S.504009 1558953 S at O76 O ein S.S.Of 122 213153 a 102 O ein S.33S163 212325 a. 102 O ein S.33S163 212327 a 102 O ein S.33S163 212328 a 109 S.408142 212779 a 109 S.408142 216294 S at 115 S.S15610 209229 s at 126 O ein S.3724.92 225598 a 128 S.461988 209378. S. at 128 S.461988 240499 a 143 S.476082 226816 s at 191 O ein KIAA1191 protein S.S19783 224.502 s at 193 S.1O1891 44822 S at 211 O ein S.479783 1564828 at 211 O ein S.479783 227230 s at 212 S.292925 23.9233 a 217 S.445.885 231807 a 219 O ein S.4367OS 224678 a 219 O ein S.4367OS 242233 a 238 O ein S.S.04670 225999 a 238 O ein S.S.04670 2261.64 x at 238 O ein S.S.04670 229344 x at 238 O ein S.S.04670 242870 a 257 S.518247 1554.852 a. at 272 O ein S.47228S 232500 a 327 O ein S.106204 225821 s at 333 S.SO9008 223254 S at 333 S.SO9008 223256 a 344 S.S32609 226747 a 345 O ein S.30382O 234936 s at 377 O ein S.156352 235956 a 387 O ein S.S16182 222270 a 393 S.38O159 221952 x at 393 S.38O159 227653 a 430 S.S35734 226254 S at 432 S.211520 226222 a 447 protein S.51458O 1559.048 at 450 protein S.377588 225924 a 450 protein S.377588 226460 a 458 protein S.4796.77 224844 a 458 protein S.4796.77 22484.5 s at 530 protein S.380475 233893 s at 536 protein S.1566.67 209002 s at 596 S.SO9229 234.733 s at 596 S.SO9229 242711 X at 600 S.192619 226155 at 608 S.435064 226849 at 632 S.546416 227638 at 632 S.546416 232030 at 641 S.516348 220940 at 666 protein S.115429 23.0062 at US 2006/01992.04 A1 Sep. 7, 2006 59

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID KIAA1698 protein KIAA1698 S.458.390 53968 at KIAA1704 KIAA1704 S.SOf 922 229078 S at KIAA1706 protein KIAA17O6 S.487994 1563621 at KIAA1712 KIAA1712 S.SS1562 241426 a KIAA1713 KIAA1713 S.464876 233536 a KIAA1718 protein KIAA1718 S.308710 221778 a KIAA1727 protein KIAA1727 S.132629 226599 a KIAA1731 protein KIAA1731 S.458418 1569302 at KIAA1754-like KIAA1754L S.65009 240037 a KIAA1772 KIAA1772 S.54838 233977 a KIAA1815 KIAA1815 S.87128 222603 a KIAA1856 protein KIAA1856 S.S2O638 229257 a KIAA1904 protein KIAA1904 S.2SO726 1559.072 a. at KIAA1935 protein KIAA1935 S.438851 226720 a KIAA1949 KIAA1949 S.1O1150 224927 a KIAA1950 protein KIAA1950 S.42221 1561179 s at KIAA1958 KIAA1958 S.533491 235112 a KIAA1961 gene KIAA1961 S.483329 239646 a KIAA1972 protein KIAA1972 S.460885 225770 a KIAA1972 protein KIAA1972 S.460885 225773 a KIAA2010 KIAA2010 S.S33887 220368 s at KIAA2026 KIAA2026 S.2SS430 2284.46 a kinectin 1 (kinesin receptor) KTN1 S.509414 200914 x at kinectin 1 (kinesin receptor) i? protein disulfide KTN1 S.509414 200915 X at isomerase-associated 6 PDIA6 kinectin 1 (kinesin receptor) i? protein disulfide KTN1 S.509414 214709 s at isomerase-associated 6 PDIA6 Kinesin 2 6070 kDa KNS2 S.2O107 21618.7 X at kinesin family member 14 KIF14 S.3104 206364 at kinesin family member 15 KIF15 S.307529 219306 at kinesin family member 18A i? kinesin family KIF18A S.3O1052 221258 s at member 18A Kinesin family member 1B KIF1B S.97858 225878 at kinesin family member 1B KIF1B S.97858 226968 at Kinesin family member 27 KIF27 S.546403 240547 at kinesin family member 2C KIF2C S.69360 2094.08 at kinesin family member 2C KIF2C S.69360 211519 s a kinesin family member 3A KIF3A S.43670 213623 at kinesin family member 3B KIF3B S.36967O 203943 at kinesin family member 5B KIFSB S.327736 201991 s a kinesin family member 5B KIFSB S.327736 201992 s a kinesin family member 5B KIFSB S.327736 224662 at Kruppel-like factor 10 KLF10 S.435OO1 202393 s a Kruppel-like factor 11 KLF11 S.12229 1553137 S at Kruppel-like factor 4 (gut) KLF4 S.3762O6 221841 s a Kruppel-like factor 5 (intestinal) KLFS S.508234 209212 s a Kruppel-like factor 7 (ubiquitous) KLF7 S.471221 1555420 a. at Kruppel-like factor 7 (ubiquitous) KLF7 S.471221 204334 at Kruppel-like factor 9 KLF9 s.150557 230636 s a Ku70-binding protein 3 KUB3 S. 61.188 227678 at kynureninase (L-kynurenine hydrolase) KYNU S.47O126 21738.8 s a kynurenine 3-monooxygenase (kynurenine 3- KMO S.409081 205306 X a hydroxylase) kynurenine 3-monooxygenase (kynurenine 3- KMO S.409081 205307 s a hydroxylase) actamase, beta LACTB S.410388 226354 at actamase, beta 2 LACTB2 S.118554 222714 S a actate dehydrogenase A LDHA S.2795 200650 s a actate dehydrogenase B LDHB S.446149 201030 x a actate dehydrogenase C LDHC S.99881 207022 s a LAG1 longevity assurance homolog 3 (S. cerevisiae) LASS3 S.416099 1554253 a at LAG1 longevity assurance homolog 6 (S. cerevisiae) LASS6 S.SO6829 235463 s a amina-associated polypeptide 1B LAP1B S.496459 212409 s a aminin, alpha 4 LAMA4 S.213861 2022.02 s a Laminin, beta 1 LAMB1 S.489646 236437 at aminin, beta 4 LAMB4 S.62022 215516 at Lanc lantibiotic synthetase component C-like 2 LANCL2 S.224282 218219 s a (bacterial) LAT1-3TM protein LAT1 S.444600 210396 s a US 2006/01992.04 A1 Sep. 7, 2006 60

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID atent transforming growth factor beta binding LTBP1 S.4978.7 202729 s a protein 1 atent transforming growth factor beta binding LTBP2 S.S12776 204682 at protein 2 LATS, large tumor Suppressor, homolog 2 LATS2 S.78960 223380 s a (Drosophila) LCHN protein LCHN S.233O44 223162 s a ectin, galactoside-binding, soluble, 3 (galectin 3) LGALS3 S.531081 208949 s a galectin-3 internal gene GALIG ectin, galactoside-binding, soluble, 8 (galectin 8) LGALS8 HS.4082 208934 S a LEM domain containing 1 LEMD1 S.181245 229927 at eptin receptor overlapping transcript PROT 202378 s a eptin receptor overlapping transcript-like 1 E PROTL1 S.146585 202594 at eptin receptor overlapping transcript-like 1 PROTL1 S.146585 202595 S a eucine proline-enriched proteoglycan (leprecan) 1 PRE1 S.437656 220750 S a eucine rich repeat (in FLII) interacting protein 1 RFIP1 S.471779 201861 s a eucine rich repeat (in FLII) interacting protein 1 RFIP1 S.471779 211452 X a eucine rich repeat (in FLII) interacting protein 1 RFIP1 S.471779 223492 s a eucine rich repeat (in FLII) interacting protein 2 RFIP2 S.47S319 220610 s a Leucine rich repeat (in FLII) interacting protein 2 RFIP2 S.47S319 230082 a Leucine rich repeat containing 16 RC16 S.116470 230793 a eucine rich repeat containing 27 RC27 S.119897 228886 a eucine rich repeat containing 6 RC6 S.1792.38 206483 a Leucine rich repeat containing 7 RC7 S.479658 242050 a Leucine rich repeat neuronal 3 LRRN3 HS.3781 243512 x at eucine Zipper protein LUZP1 S.257900 1558173 a at eucine Zipper protein LUZP1 S.257900 225831 a eucine Zipper, down-regulated in cancer 1 LDOC1 S.45231 204454 a eucine Zipper-EF-hand containing transmembrane LETM2 S.264887 1552546 a. at protein 2 eucine-rich PPR-motif containing LRPPRC S.368O84 211971 s a eucine-rich repeats and immunoglobulin-like LRIG2 S.448.972 205953 a domains 2 eucyl-tRNA synthetase LARS S.432674 222427 s a eukocyte receptor cluster (LRC) member 10 LENG10 1564776 at eukocyte receptor cluster (LRC) member 8 LENG8 S.SO2378 224673 a Leukotriene B4 12-hydroxydehydrogenase LTB4DH S.546348 242775 a eupaxin LPXN S.125474 216250 s a eupaxin LPXN S.125474 242778 a ikely ortholog of chicken chondrocyte protein with C HPPR S.521608 203208 s a 8. poly-proline region ikely ortholog of mouse gene trap locus 3 GTL3 S.532755 217957 a ikely ortholog of mouse hypoxia induced gene 1 HIG1 HS.7917 217845 x a kely ortholog of mouse immediate early response, LEREPO4 S.368598 201593 s a rythropoietin 4 kely ortholog of mouse immediate early response, LEREPO4 S.368598 201595 S a rythropoietin 4 ikely ortholog of mouse la related protein LARP S.292O78 212137 a ikely ortholog of mouse limb-bud and heart gene LBH S.468044 221011 s a fit likely ortholog of mouse limb-bud and heart gene ikely ortholog of mouse neighbor of Punc E11 S.4586O7 227870 a ikely ortholog of mouse Sds3 S.41663.O 224974 a ikely ortholog of mouse spermatogenic Zip 1 S.5.19403 224167 a ikely ortholog of mouse TORC2-specific protein S.4O7926 228248 a AVO3 (S. cerevisiae) LIM and Senescent cell antigen-like domains 3 MS3 S.469633 223800 s at LIM and SH3 protein 1 ASP1 S.334851 200618 a LIM domain binding 3 DB3 S.49998 213371 a LIM domain containing preferred translocation PP S.444362 202822 a partner in lipoma LIM domains containing 1 MD1 S.193370 234687 x at LIM homeobox2 HX2 S.445265 2061.40 a LIM homeobox 4 HX4 S.4965.45 1553157 at Limkain beta 2 LJ22471 S.114111 1556624 at imkain beta 2 LJ22471 S.114111 218175 a in-28 homolog (C. elegans) N28 S.86154 2198.23 a ipin 1 PIN1 S.467740 212272 a ipin 1 PIN1 S.467740 212274 a ipin 1 PIN1 S.467740 212276 a US 2006/01992.04 A1 Sep. 7, 2006 61

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID ipin 2 LPIN2 S.268581 202459 s at ipocalin 6 LCN6 S.98132 238071 at Lipoma HMGIC fusion partner LHFP S.SOf798 232935 at LOC132671 LOC132671 S.S27090 229331 at LOC132671 LOC132671 S.S27090 230723 at LOC136263 LOC136263 S.351816 1553329 at LOC150368 protein LOC1 SO368 S.368312 2265.04 at LOC3994.91 protein LOC3994.91 214035 x at LOC43998.7 S.164298 229318 at LOC43998.7 S.164298 2326O1 at LOC44O13S S.S4.9373 234.056 at LOC44O135 Homo sapiens, clone S.37S766 228913 at MAGE: 2900578, mRNA, partial cols S.S4.9373 LOC440286 LOC44O286 S.419760 237017 s at LOC440309 S.459403 225951 S. at LOC440441 S.463231 23.0388 s at LOC440448 S.S28952 224806 at LOC440460 SH3GLP3 S.293560 227567 at LOC44.0570 S.308060 241835 at LOC44.0570 LOC44.0570 S.308060 242884 at LOC44.0667 LOC44.0667 S.549388 22.9872 s at LOC440701 LOC440701 S.550597 225722 at LOC440806 S.474303 224621 at LOC440918 S.74921 230203 at LOC441297 LOC441297 S.S35040 228899 at LOC441423 LOC441423 S.S35066 241803 s at LOC441434 S.3S1215 1554516 at LOC441434 S.3S1215 1554517 xat LOC441699 S.S3S102 1566887 X at oss of heterozygosity, 3, chromosomal region 2, S.4331.51 220244 at gene A ow molecular mass ubiquinone-binding protein S.1466O2 201568 at (9.5 kD) LPS-responsive vesicle trafficking, beach and S.480938 212692 s at anchor containing LPS-responsive vesicle trafficking, beach and S.480938 214109 at anchor containing LUC7-like (S. cerevisiae) 223295 S at LUC7-like 2 (S. cerevisiae) S.530118 220099 s at ung cancer-related protein 8 S.12929 223352 s at ymphocyte adaptor protein S.SO6784 203320 at ymphocyte antigen 6 complex, locus G5C S.25738 219860 at ymphocyte antigen 6 complex, locus G6C S.241586 207114 at ymphoid enhancer-binding factor 1 S.125132 243362 s at ymphoid enhancer-binding factor 1 S.125132 243363 at LYRIC3D3 S.377155 212250 at LYRIC3D3 S.377155 212251 at ySophosphatidylglycerol acyltransferase 1 S.497674 1555.058 a. at ySophospholipase I S.435850 203007 X at ySophospholipase II similar to Acyl-protein S.S34O75 202292 x at hioesterase 2 (Lysophospholipase II) (LPL-I) LOC388499 ysosomal associated protein transmembrane 4 LAPTM4B S.492314 214039 s at beta ysosomal trafficking regulator LYST S.532411 210943 s at ysosomal-associated membrane protein 1 LAMP1 S.494419 201552 at ysosomal-associated membrane protein 1 LAMP1 S.494419 201553 S at ysosomal-associated membrane protein 3 LAMP3 S.518448 205569 at ysosomal-associated protein transmembrane 4 LAPTM4A S.467807 200673 at alpha ysyl-tRNA synthetase KARS HS-3100 200840 at M8 protein LOC149830 S.126516 233975 at macrophage erythroblast attacher MAEA S.1398.96 207922 s at MAD1 mitotic arrest deficient-like 1 (yeast) MAD1L1 S.209128 233921 s at MADS box transcription enhancer factor 2, MEF2A S.268675 239571 at polypeptide A (myocyte enhancer factor 2A) Major histocompatibility complex, class I, A HLA-A S.549038 213932 x at major histocompatibility complex, class II, DM HLA S.3S1279 217478 s at alpha DMA US 2006/01992.04 A1 Sep. 7, 2006 62

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID major histocompatibility complex, class II, DM beta HLA S.1162 203932 at if major histocompatibility complex, class II, DM DMB beta major histocompatibility complex, class II, DR beta HLA S.520049 209312 x at 1 major histocompatibility complex, class II, DR DRB1 beta 1 Major histocompatibility complex, class II, DR beta 4 HLA S.520049 208306 x at DRB1 Mak3 homolog (S. cerevisiae) MAK3 S.269528 231199 at Mak3 homolog (S. cerevisiae) MAK3 S.269528 244341 at makorin, ring finger protein, 1 MKRN1 S.49.0347 209845 at makorin, ring finger protein, 1 makorin, ring MKRN1 S.49.0347 201285 at finger protein, 1 makorin, ring finger protein, 2 MKRN2 S.279474 22251.0 s at mal, T-cell differentiation protein MAL S.8O395 204777 s at malic enzyme 1, NADP(+)-dependent, cytosolic ME1 S.21160 204059 s at Mannose receptor, C type 2 MRC2 S.783S 244788 a MAP kinase interacting serine threonine kinase 1 MKNK1 S.371594 209467 s at MAP kinase interacting serine threonine kinase 1 MKNK1 S.371594 243256 a MAP kinase interacting serine threonine kinase 2 MKNK2 S.S1SO32 218205 s at MAP microtubule affinity-regulating kinase 1 MARK1 S.497806 221047 s at MAP microtubule affinity-regulating kinase 1 MARK1 S.497806 226653 a MARCKS-like 1 MARCKSL1 S.7SO61 200644 a Mariner-like element-containing mRNA, clone S.546722 239409 a pcHMT2. mastermind-like 2 (Drosophila) MAML2 S.428214 235457 a Mastermind-like 2 (Drosophila) MAML2 S.428214 244414 a Mastermind-like 3 (Drosophila) MAML3 S.444627 242794 a maternally expressed 3 MEG3 S.S2SS89 212732 a matrin 3 MATR3 S.268939 214363 s at matrix metalloproteinase 12 (macrophage MMP12 S.1695 204580 a elastase) matrix metalloproteinase 19 MMP19 S.154057 204574 S at matrix metalloproteinase 9 (gelatinase B, 92 kDa MMP9 S.297413 203936 s at gelatinase, 92 kDa type IV collagenase) MAX dimerization protein 1 MAD S.468,908 226275 a MAX-like protein X MLX S.383019 213708 s at MBC32OS UNQ501 S.8O36 225003 a Mbt domain containing 1 BTD1 S.369586 226797 a MCF.2 cell line derived transforming sequence-like CF2L S.170422 243983 a McKusick-Kaufman syndrome KKS S.472119 222530 s at MCM3 minichromosome maintenance deficient 3 CM3APAS S.S17368 220459 a (S. cerevisiae) associated protein antisense Mdm4, transformed 3T3 cell double minute 1, p53 DM1 S.171265 213761 a binding protein (mouse) Mdm4, transformed 3T3 cell double minute 4, p53 DM4 S.497492 225740 x at binding protein (mouse) Mdm4, transformed 3T3 cell double minute 4, p53 DM4 S.497492 235589 S at binding protein (mouse) mediator of DNA damage checkpoint 1 DC1 S.433653 203062 s at mediator of RNA polymerase II transcription, ED19 S.43619 226293 at Subunit 19 homolog (yeast) mediator of RNA polymerase II transcription, ED19 S.43619 226300 at Subunit 19 homolog (yeast) Mediator of RNA polymerase II transcription, ED31 S.43566 236241 at Subunit 31 homolog (yeast) mediator of RNA polymerase II transcription, ED9 S.244595 218372 at Subunit 9 homolog (yeast) meiosis-specific nuclear structural protein 1 S.444483 219703 at Meis1, myeloid ecotropic viral integration site 1 EIS1 S.S26754 204069 at homolog (mouse) Meis1, myeloid ecotropic viral integration site 1 EIS2 SS10989 207480 s at homolog 2 (mouse) mel transforming oncogene-like 1 ELL1 S.546429 1552.930 at melanoma antigen family B, 2 AGEB2 S.113824 206218 at melanoma associated antigen (mutated) 1 UM1 S.S15O16 221290 s at melanoma associated antigen (mutated) 1 UM1 S.S15O16 223347 at Melanoma associated gene D2S448 S.332197 212012 at melanophilin LPH S.1024O6 218211 s at membrane cofactor protein (CD46, trophoblast S.5104O2 207549 X at lymphocyte cross-reactive antigen) US 2006/01992.04 A1 Sep. 7, 2006 63

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID membrane component, chromosome 11, Surface M11 S1 S.47 1818 200722 s at marker 1 Membrane component, chromosome 11, Surface M11 S1 S.47 1818 226990 a marker 1 Membrane component, chromosome 11, Surface M11 S1 S.47 1818 244778 x at marker 1 membrane frizzled-related protein MFRP S.S12769 224286 a membrane progestin receptor alpha MPRA S.S23652 2421.23 a membrane-associated guanylate kinase-related MAGI-3 S.486189 226770 a (MAGI-3) membrane-associated ring finger (C3HC4) 5 5-Mar S.5491.65 218582 a membrane-associated ring finger (C3HC4) 6 6-Mar S.432862 201737 S a membrane-associated ring finger (C3HC4) 7 7-Mar S.S29272 202654 x a membrane-associated ring finger (C3HC4) 8 8-Mar S.499489 231933 a membrane-spanning 4-domains, subfamily A, MS4A6E S.12658O 231,335 a. member 6E meningioma expressed antigen 5 (hyaluronidase) MGEAS S.SOO842 200898 s a meningioma expressed antigen 5 (hyaluronidase) MGEAS S.SOO842 223494 a mesenchymal stem cell protein DSC92 NEUGRIN S.S13145 217722 s a Mesenchymal stem cell protein DSC92 NEUGRIN S.S13145 228541 x a mesoderm development candidate 2 MESDC2 S.S13070 224675 a mesoderm posterior 2 MESP2 S.37311 1556O15 a. at metallothionein-like 5, testis-specific (tesmin) MTL5 S.145932 219786 a metal-regulatory transcription factor 1 MTF1 S.47 1991 205323 s a metastasis associated 1 if metastasis associated 1 MTA1 S.S2S629 211783 s a metastasis associated lung adenocarcinoma MALAT1 S.1871.99 1558678 s at transcript 1 (non-coding RNA) metastasis associated lung adenocarcinoma MALAT1 S.1871.99 224.558 s a transcript 1 (non-coding RNA) Metastasis associated lung adenocarcinoma MALAT1 S.1871.99 228582 x a transcript 1 (non-coding RNA) methionine adenosyltransferase II, alpha MAT2A S.S16157 200768 s a methionine adenosyltransferase II, alpha MAT2A S.S16157 200769 s a Methionine adenosyltransferase II, alpha MAT2A S.S16157 213705 at methionine adenosyltransferase II, beta MAT2B S.54642 217993 s a Methionine sulfoxide reductase A MSRA S.490981 237798 at methionyl aminopeptidase 2 METAP2 S.444986 213899 at Methionyl aminopeptidase 2 METAP2 S.444986 244.185 at methyl-CpG binding domain protein 4 S.35947 209579 is a methyl-CpG binding domain protein 5 S.458312 2201.95 at Methylcrotonoyl-Coenzyme A carboxylase 2 (beta) S.167531 1556345 s at methylcrotonoyl-Coenzyme A carboxylase 2 (beta) S.167531 209623 at methylenetetrahydrofolate dehydrogenase S.268698 225520 at (NADP+ dependent) 1-like Methylmalonic aciduria (cobalamin deficiency) type A 242750 at Methylosome protein 50 242398 x at methylthioadenosine phosphorylase TAP 211364 at Methyltransferase 5 domain containing 1 33 243736 at methyltransferase like 4 s 2 6 8 8 8 219698 s at methyltransferase like 5 221570 s at mevalonate kinase (mevalonic aciduria) 36907 at MHC class II transactivator A 241520 x at MICAL-like 1 55081 at 1 microfibrillar-associated protein 1 FAP 203406 at microfibrillar-associated protein 3-like FAP3L 210493 s at microfibrillar-associated protein 3-like FAP3L 7 8 1 2 1 210843 s at microseminoprotein, beta 210297 s at microtubule associated monoxygenase, calponin CAL2 212473 s at and LIM domain containing 2 microtubule associated monoxygenase, calponin MICAL3 229474 at and LIM domain containing 3 microtubule associated serine/threonine kinase MAST4 S.133539 225613 at family member 4 microtubule-associated protein 1 light chain 3 MAP1LC3A S.472513 227219 x at alpha microtubule-associated protein 1 light chain 3 beta MAP1LC3B S.356061 208785 S at Microtubule-associated protein 1B MAP1B S.S35786 212233 at microtubule-associated protein 4 MAP4 S.S17949 212566 at microtubule-associated protein 4 MAP4 S.S17949 243 g at US 2006/01992.04 A1 Sep. 7, 2006 64

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbo UniGene ID Probe Set ID microtubule-associated protein, RP/EB family, MAPRE1 S.472437 200712 s a member 1 microtubule-associated protein, RP/EB family, MAPRE1 S.472437 200713 s a member 1 microtubule-associated protein, RP/EB family, MAPRE2 S.532824 2025O1 at member 2 midline 1 (Opitz/BBB syndrome) MID1 S.27695 203637 S a midline 2 MID2 S.12256 208,384 S a misato MST S.279763 218296 x a misato MST S.279763 224233 s a mitochondrial capsule selenoprotein MCSP S.111850 2064.06 at mitochondrial carrier homolog 1 (C. elegans) MTCH1 S.485262 221619 s a mitochondrial carrier homolog 2 (C. elegans) MTCH2 S.269944 222403 at mitochondrial carrier protein MGC4399 S.443826 223296 at mitochondrial carrier triple repeat 1 MCART1 S.46791 232092 at mitochondrial ribosomal protein 63 MRP63 S.458367 204386 s a mitochondrial ribosomal protein 63 MRP63 S.458367 20438.7 x a mitochondrial ribosomal protein L15 MRPL15 S.18349 218027 at mitochondrial ribosomal protein L3 MRPL3 S.2O5163 208787 at mitochondrial ribosomal protein L30 MRPL30 S.346736 224971 at Mitochondrial ribosomal protein L30 MRPL30 S.346736 243801 x a mitochondrial ribosomal protein L32 MRPL32 S.SO2S2 225260 s a mitochondrial ribosomal protein L33 MRPL33 S.S15879 203781 at mitochondrial ribosomal protein L36 MRPL36 S.321.96 224331 s a mitochondrial ribosomal protein L36 mitochondrial ribosomal protein L39 MRPL39 S.420696 218558 s a Mitochondrial ribosomal protein L43 MRPL43 S.421848 1556078 at mitochondrial ribosomal protein L51 MRPLS1 S.SS847 22308.6 X a mitochondrial ribosomal protein L9 MRPL9 S.288936 O9609 s a mitochondrial ribosomal protein S10 MRPS10 S.38O887 8106 s a mitochondrial ribosomal protein S14 MRPS1.4 S.247324 O3800 s a mitochondrial ribosomal protein S17 MRPS17 S.44298 8982 s a mitochondrial ribosomal protein S18B MRPS18B S.274417 7408 at mitochondrial ribosomal protein S21 MRPS21 S.40588O 22997 s a mitochondrial ribosomal protein S24 MRPS24 S.284286 24948 at mitochondrial ribosomal protein S28 MRPS28 S.521124 98.19 s a Mitochondrial ribosomal protein S6 MRPS6 S.3O2742 2944 at mitochondrial ribosomal protein S6 MRPS6 S.3O2742 24919 at mitochondrial ribosomal protein S7 MRPS7 S.71 787 7932 at mitochondrial ribosome recycling factor MRRF S.368O11 25126 at mitochondrial Solute carrier protein MSCP S.122514 8136 s a Mitochondrial solute carrier protein MSCP S.122514 21155 x a mitochondrial Solute carrier protein MSCP S.122514 22529 at Mitochondrial solute carrier protein MSCP S.122514 237568 at mitochondrial translation optimization 1 homolog MTO1 S.347614 218716 x a (S. cerevisiae) mitochondrial translation optimization 1 homolog MTO1 S.347614 23366S X a (S. cerevisiae) mitochondrial translational initiation factor 2 MTIF2 S.1498.94 203095 a mitochondrial translational initiation factor 3 MTIF3 S.S34582 223356 s a mitofusin 2 MFN2 S.376.681 216205 s a mitogen-activated protein kinase 10 MAPK10 S.25209 204813 a mitogen-activated protein kinase 13 MAPK13 S.178695 2100.58 a mitogen-activated protein kinase 13 MAPK13 S.178695 210059 s a mitogen-activated protein kinase 8 MAPK8 S.522924 226048 a Mitogen-activated protein kinase 8 MAPK8 S.522924 229664 a mitogen-activated protein kinase kinase 4 MAP2K4 S.514681 203265 s a mitogen-activated protein kinase kinase 4 MAP2K4 S.514681 203266 s a Mitogen-activated protein kinase kinase 5 MAP2KS S.1141.98 235.601 a mitogen-activated protein kinase kinase kinase 1 MAP3K1 S.508461 225927 a mitogen-activated protein kinase kinase kinase 2 MAP3K2 S.145605 226979 a mitogen-activated protein kinase kinase kinase MAP4K4 S.431SSO 206571 s a kinase 4 Mitogen-activated protein kinase kinase kinase MAP4K4 S.431SSO 244846 a kinase 4 mitogen-activated protein kinase kinase kinase MAP4KS S.130491 203553 S a kinase 5 mixed lineage kinase 4 KIAA1804 S.S4645S 228565 a. MLF1 interacting protein MILF1IP S.481307 218883 s a MLF1 interacting protein MILF1IP S.481307 2293.05 a Mix interactor MONDOA S.437153 2251.57 a

US 2006/01992.04 A1 Sep. 7, 2006 66

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID MRNA, cDNA DKFZp686.JO929 (from clone S.37.6849 566.032 at DKFZp686.JO929) MRNA, cDNA DKFZp686N1136 (from clone S.S48588 557589 a. at DKFZp686N1136) MRNA, cDNA DKFZp761 B0221 (from clone S.S4.1755 563715 at DKFZp761B0221) MRNA, cDNA DKFZp761I2317 (from clone S.442983 558142 at DKFZp761I2317) MRNA, cDNA DKFZp761I2317 (from clone S.442983 238468 at DKFZp761I2317) MRNA, cDNA DKFZp762C074 (from clone S.S46985 560661 x at DKFZp762C074) mSin3A-associated protein 130 SAP130 S.32995 mucin 17 MUC17 S.271819 mucin 19 MUC19 S.244O17 553436 at mucin 3A, intestina MUC3A S.S33959 217117 x at mucin 4, tracheobronchial MUC4 S.369646 217109 at mucosa associated lymphoid tissue lymphoma MALT1 S.180566 210017 at translocation gene 1 multimerin 2 MMRN2 S.524479 219091 s at multiple C2-domains with two transmembrane MCTP2 S.33368 220603 s at regions 2 Multiple C2-domains with two transmembrane MCTP2 S.33368 2398.93 at regions 2 Multiple C2-domains with two transmembrane MCTP2 S.33368 243109 at regions 2 multiple PDZ domain protein S.169378 205079 S at MUS81 endonuclease homolog (yeast) S.288798 218463 s at musashi homolog 2 (Drosophila) S.134470 225240 S at Muscleblind-like (Drosophila) S.478OOO 1556658 a. at Muscleblind-like (Drosophila) S.478OOO 235879 at Muscleblind-like (Drosophila) S.478OOO 241681 at Muscleblind-like 2 (Drosophila) S.125715 232138 at muted homolog (mouse) 226544 x at MYC associated factor X S.285354 209332 S at MYC induced nuclear antigen S476.972 213188 s at myelin expression factor 2 S.SS2594 222771 s at myelin expression factor 2 S.SS2594 232676 x at myelin protein zero-like 1 S.493919 210210 at myelin transcription factor 1 S.279562 1556269 at myelin-associated oligodendrocyte basic protein S.121333 2O7659 s at myelin-associated oligodendrocyte basic protein S.121333 242765 at myeloid cell leukemia sequence 1 (BCL2-related) S.532826 200797 s at myeloid cell leukemia sequence 1 (BCL2-related) S.532826 200798 X at Myeloid cell leukemia sequence 1 (BCL2-related) S.532826 214057 at myeloid differentiation primary response gene (88) MYD88 S.82116 209124 at myeloid leukemia factor 1 S.851.95 204784 S at myeloid lymphoid or mixed-lineage leukemia M LL S.2588SS 156525.4 S at (trithorax homolog, Drosophila) i? elongation factor RNA polymerase II myeloid lymphoid or mixed-lineage leukemia 1563321 S at (trithorax homolog, Drosophila); translocated to, 10 Myeloid lymphoid or mixed-lineage leukemia 237600 at (trithorax homolog, Drosophila); translocated to, 10 Myeloid lymphoid or mixed-lineage leukemia 243003 at (trithorax homolog, Drosophila); translocated to, 10 myeloid lymphoid or mixed-lineage leukemia LLT2 S.4801.90 201924 at (trithorax homolog, Drosophila); translocated to, 2 Myeloid lymphoid or mixed-lineage leukemia 2 S.4801.90 237006 at (trithorax homolog, Drosophila); translocated to, 2 myeloid lymphoid or mixed-lineage leukemia 3 LL3 S.2704.92 222413 s at myeloid lymphoid or mixed-lineage leukemia 5 LLS S.SS1548 223190 s at (trithorax homolog, Drosophila) myeloid-associated differentiation marker YADM S.380906 2256.73 at myoglobin B S.S17586 2041 79 at myo-inositol monophosphatase A3 IMPA3 S.438689 224743 at Myomesin family, member 3 MYOM3 S.523413 23.8124 at myoneurin MYNN SSOTO2S 224206 x at myosin head domain containing 1 MYOHD1 S.302051 219320 at myosin head domain containing 1 MYOHD1 S.302051 225947 at myosin IG MYO1G S.37617 244654 at US 2006/01992.04 A1 Sep. 7, 2006 67

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID myosin IIIA S.131367 244364 at myosin IXA S.546268 219027 s at Myosin DXA S.546268 242512 at myosin light chain 1 slow a S.S24500 204173 at myosin phosphatase-Rho interacting protein S.462341 214771 x at myosin regulatory light chain MRCL3 if myosin S.464,472 201318 s at regulatory light chain MRLC2 MR myosin regulatory light chain MRLC2 MR S.464,472 221474 a myosin VB MYOSB S.5SO481 225299 a myosin XVA MYO15A S.462390 220288 a myosin, heavy polypeptide 10, non-muscle MY S.16355 212372 a myosin, light polypeptide 4, alkali; atrial, embryonic MY S.4633OO 216054 x at myosin, light polypeptide 6, alkali, Smooth muscle MY S.505705 21208.2 s at and non-muscle myosin, light polypeptide kinase MY S.477375 224823 a myotubularin related protein 12 MTMR12 S.481836 220953 S at myotubularin related protein 2 MTMR2 S.181326 203211 s at myotubularin related protein 2 MTMR2 S.181326 214649 s at Myotubularin related protein 3 MTMR3 S.47453.6 240271 a myotubularin related protein 4 MTMR4 S.S14373 214268 s at myotubularin related protein 9 MTMR9 S.S28673 204837 a myotubularin related protein 9 MTMR9 S.S28673 213278 a myristoylated alanine-rich protein kinase C MARCKS S.S19909 201669 s at Substrate Myristoylated alanine-rich protein kinase C MARCKS S.S19909 213002 a Substrate MYST histone acetyltransferase (monocytic MYST3 S.491577 202423 a leukemia) 3 MYST histone acetyltransferase 2 / MYST histone MYST2 S.21907 200049 a acetyltransferase 2 N-acetylated alpha-linked acidic dipeptidase 2 NAALAD2 S.SO3S60 233815 a. N-acetylated alpha-linked acidic dipeptidase 2 NAALADL2 S.86024 236818 a N-acetylgalactosaminidase, alpha NAGA S.75372 202943 s at N-acetylneuraminate pyruvate lyase NPL S.496969 240440 a (dihydrodipicolinate synthase) N-acetylneuraminic acid synthase (sialic acid NANS S.5223.10 21818.9 s at synthase) N-acetyltransferase 1 (arylamine N NAT S.155956 214440 a acetyltransferase) N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) NATS S.368783 223040 a N-acetyltransferase-like protein FLJ10774 S.S23598 217884 a NACHT, leucine rich repeat and PYD (pyrin NALP1 S.104305 1562256 at domain) containing 1 if NACHT, leucine rich S.S13902 repeat and PYD (pyrin domain) containing 1 NACHT, leucine rich repeat and PYD (pyrin NALP1 S.104305 1562257 X at domain) containing 1 if NACHT, leucine rich S.S13902 repeat and PYD (pyrin domain) containing 1 N-acyl-phosphatidylethanolamine-hydrolyzing NAPEPLD S.324271 233539 at phospholipase D N-acyl-phosphatidylethanolamine-hydrolyzing NAPEPLD S.324271 238722 x at phospholipase D N-acyl-phosphatidylethanolamine-hydrolyzing NAPEPLD S.324271 242635 S. at phospholipase D N-acylsphingosine amidohydrolase (aci ASAH1 S.S27412 210980 S at ceramidase) 1 N-acylsphingosine amidohydrolase (aci ASAH1 S.S27412 213702 x at ceramidase) 1 N-acylsphingosine amidohydrolase (aci ASAH1 S.S27412 213902 at ceramidase)8. 1 N-acylsphingosine amidohydrolase (aci ASAHL S.43736S 215178 X at ceramidase)-like NAD kinase FLJ13052 S.456572 208918 s at NADH dehydrogenase (ubiquinone) 1 alpha NDUFA10 S.277677 217860 at Subcomplex, 10, 42 kDa NADH dehydrogenase (ubiquinone) 1 alpha NDUFAS S.83916 201304 at Subcomplex, 5, 13 kDa NADH dehydrogenase (ubiquinone) 1 alpha NDUFA9 S.75227 208969 at Subcomplex, 9, 39 kDa NADH dehydrogenase (ubiquinone) 1 beta NDUFB1 S.1834-35 206790 S at Subcomplex, 1, 7 kDa US 2006/01992.04 A1 Sep. 7, 2006 68

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID NADH dehydrogenase (ubiquinone) 1 beta DUFB2 S.3242SO 218200 s at Subcomplex, 2, 8 kDa NADH dehydrogenase (ubiquinone) 1 beta DUFB2 S.3242SO 218201 at Subcomplex, 2, 8 kDa NADH dehydrogenase (ubiquinone) 1 beta DUFB6 S.493668 1559.042 at Subcomplex, 6, 17 kDa NADH dehydrogenase (ubiquinone) 1 beta DUFB6 S.493668 2036.13 s a Subcomplex, 6, 17 kDa H dehydrogenase (ubiquinone) 1 beta DUFB8 S.S23215 201227 s a Subcomplex, 8, 19 kDa H dehydrogenase (ubiquinone) 1 beta DUFB9 S.15977 222992 s a Subcomplex, 9, 22 kDa DH dehydrogenase (ubiquinone) Fe—S protein S.408257 203606 at 3 kDa (NADH-coenzyme Q reductase) NADH dehydrogenase (ubiquinone) Fe—S protein FS 8 S.90443 232169 x a 3 kDa (NADH-coenzyme Q reductase) NADPHD cytochrome B5 S.5741 219079 at napsin Baspartic peptidase pseudogene S.322854 228.056 S a nardilysin (N-arginine dibasic convertase) DU S.SS1509 208709 S a Nardilysin (N-arginine dibasic convertase) S.SS1509 229422 at Nardilysin (N-arginine dibasic convertase) S.SS1509 242235 x a nasal embryonic LHRH factor S.455336 221214 S a nascent-polypeptide-associated complex alpha A.C A. S.505735 20073S X a polypeptide nascent-polypeptide-associated complex alpha NA. C A. S.505735 208635 X a polypeptide natural killer-tumor recognition sequence S.S29 SO9 1557737 s at NCK adaptor protein 1 CK1 S.477693 2298.95 s a NCK adaptor protein 1 CK1 S.477693 233274 at NCK adaptor protein 1 / NCK adaptor protein 1 S.477693 211063 s a Nedd4 binding protein 1 S.S11839 48612 at Nedd4 family interacting protein 2 S.S2SO93 224799 at Nedd4 family interacting protein 2 D IP 2 S.S2SO93 224801 at Neighbor of BRCA1 gene 1 S S.SSOS89 1568857 a. at neighbor of BRCA1 gene 1 S.277721 201383 s at Nemo like kinase S.2O8759 1556568 a at nemo like kinase S.2O8759 222589 at Nemo like kinase S.2O8759 238624 at nephrosis 2, idiopathic, steroid-resistant (podocin) S.412710 220424 at N-ethylmaleimide-sensitive factor S.431279 1566785 X at Neural cell adhesion molecule 1 S.SO3878 227394 at neural precursor cell expressed, developmentally S.27OO84 156O116 a. at down-regulated 1 neural precursor cell expressed, developmentally E D D4 L S.185677 212445 S at down-regulated 4-like Neural precursor cell expressed, developmentally E D D4 L S.185677 226974 a down-regulated 4-like neurobeachin S.491172 221207 s at neurobeachin E S.491172 226439 s at neuroepithelial cell transforming gene 1 S.25155 201829 a neurofibromin 1 (neurofibromatosis, von S.435956 204325 s at Recklinghausen disease, Watson disease) neurofilament 3 (150 kDa medium) S.458657 205113 a neurofilament, heavy polypeptide 200 kDa S.19876O 33767 at neuroligin 2 LG 2 S.26229 1554428 s at Neurolysin (metallopeptidase M3 family) S.247460 234762 x at neuron navigator 1 S.497369 224772 a. neuron navigator 2 sS. S.502116 1556.606 at Neuronal PAS domain protein 3 S.S.09113 239611 a neuro-oncological ventral antigen 1 S.211225 205794 S at neuropeptide Y S.1832 206001 a neuropeptide Y receptor Y5 S.S19058 207400 a neurotrophic tyrosine kinase, receptor, type 3 S.410969 206462 s at neurotrophic tyrosine kinase, receptor, type 3 S.410969 217033 x at neurotrophic tyrosine kinase, receptor, type 3 NTRK3 S.410969 217377 X at Neutral sphingomyelinase (N-SMase) activation NSMAF S.372OOO 232148 a associated factor Nexilin (F actin binding protein) NEXN S.22370 212847 a NFS1 nitrogen fixation 1 (S. cerevisiae) NES1 S.194692 21.8455 a NGFI-A binding protein 1 (EGR1 binding protein 1) NAB1 S.107474 211139 s at Ngg1 interacting factor 3 like 1 binding protein 1 NIF3L1BP1 S.288.151 218334 a US 2006/01992.04 A1 Sep. 7, 2006 69

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID N-glycanase 1 NGLY1 S.368,960 2 20742 s at NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) NHP2L1 S.1822SS 2 01.077 s at nicotinamide nucleotide adenylyltransferase 2 NMNAT2 S.497.123 1 552712 a. at nicotinamide nucleotide adenylyltransferase 2 NMNAT2 S.497.123 1 556029 S. at nicotinamide nucleotide transhydrogenase NNT S.482O43 2 38530 at NiflJ-like N-terminal domain containing FUN S350702 2 O9075 S. at Nijmegen breakage syndrome 1 (nibrin) BS1 S.4922O8 2 O2907 s at NIMA (never in mitosis gene a)-related kinase 11 EK11 S.200813 2 95.42 at NIMA (never in mitosis gene a)-related kinase 1 EK1 S.481181 1 564093 at NIMA (never in mitosis gene a)-related kinase 1 EK1 S.481181 2 3328 at NIMA (never in mitosis gene a)-related kinase 2 EK2 S.153704 2 04641 at NIMA (never in mitosis gene a)-related kinase 2 // EK2 S.153704 2 NIMA (never in mitosis gene a)-related kinase 2 NIMA (never in mitosis gene a)-related kinase 3 if 2 NIMA (never in mitosis gene a)-related kinase 3 NIMA (never in mitosis gene a)-related kinase 6 EK6 S.197071 2315.9 s at Nipped-B homolog (Drosophila) PBL S.481927 3918 s at nischarin SCH S.435290 O1591 s at nitric oxide synthase 3 antisense OS3AS S.S46535 29252 at nitric oxide synthase interacting protein OSIP S.7236 7950 at NK3 transcription factor related, locus 1 KX3-1 S.SS999 09706 at (Drosophila) NMD3 homolog (S. cerevisiae) S.4928OS 2 8036 x at NMD3 homolog (S. cerevisiae) S.4928OS 2 22497 X at N-myc downstream regulated gene 1 S.372914 2 O0632 s at NODAL modulator 2 S.227823 2 7225 X at NOL1/NOP2 Sun domain family, member 3 S.4O1062 2 9458 s at NOL1/NOP2/Sun domain family, member 4 S.163424 2 26351a. NOL1/NOP2 Sun domain family, member 4 S.163424 2 36247 a NOL1/NOP2 Sun domain family, member 4 S.163424 242741 X at NOL1/NOP2 Sun domain family, member 6 S.3961.75 2 30200 a NOL1/NOP2 Sun domain family, member 6 S.3961.75 2 42239 a non-metastatic cells 5, protein expressed in S.5196O2 2 O6197 a (nucleoside-diphosphate kinase) normal mucosa of esophagus specific 1 NMES1 S.112242 2 23484 a Notch homolog 2 (Drosophila) NOTCH2 S.S490S6 2 O2443 X a Notch homolog 2 (Drosophila) N-terminal like NOTCH2NL S.5O2564 2 14722 a NSE1 NSE S.2608SS 2 34331 s a N-terminal asparagine amidase NTAN1 S.351573 2 13061 s a nuclear autoantigenic sperm protein (histone NASP S.319334 2 O1969 a binding) nuclear cap binding protein subunit 2, 20 kDa BP2 S.240770 2 O1517 a nuclear cap binding protein subunit 2, 20 kDa BP2 S.240770 2 O1521 S a nuclear distribution gene C homolog (A. nidulans) N. DC S.263812 2 10574 s a nuclear domain 10 protein P52 S.514920 1 560631 at nuclear domain 10 protein P5 2 S.514920 2 38560 a nuclear factor (erythroid-derived 2)-like 1 E2 L 1 S.514284 2 00759 X a nuclear factor (erythroid-derived 2)-like 2 S.155396 2 O1146 a nuclear factor (erythroid-derived 2)-like 3 S.404741 2 04702 s a Nuclear factor IB S.370359 2 O9289 a nuclear factor IB S.370359 2 O9290 s a Nuclear factor IB S.370359 2 30791 a Nuclear factor IC (CCAAT-binding transcription S.1701.31 2 26895 a factor) nuclear factor of activated T-cells, cytoplasmic, FATC3 S.341716 2 10556 a calcineurin-dependent 3 Nuclear factor of kappa light polypeptide gene FKB1 S.431926 2 39876 a enhancer in B-cells 1 (p105) nuclear factor of kappa light polypeptide gene FKBIZ. S.319171 2 23217 s at enhancer in B-cells inhibitor, Zeta nuclear factor of kappa light polypeptide gene FKBIZ. S.319171 2 23218 s at enhancer in B-cells inhibitor, Zeta nuclear factor, interleukin 3 regulated FIL3 2 O3574 at nuclear fragile X mental retardation protein NUFIP1 2 O5134 S. at interacting protein 1 nuclear phosphoprotein similar to S. Cerevisiae PWP1 S.S.06652 2 O1606 s at PWP1 nuclear pore complex interacting protein if NPIP S.S28782 2 O4538 x at hypothetical protein LOC339047 i? similar to LOC339047 hypothetical protein LOC339047 LOC440341 US 2006/01992.04 A1 Sep. 7, 2006 70

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID nuclear pore complex interacting protein if NPIP S.S28782 214870 x a hypothetical protein LOC339047 i? similar to LOC339047 hypothetical protein LOC339047 LOC440341 nuclear protein UKp68 FLJ11806 S.325846 204216 s a nuclear protein UKp68 FLJ11806 S.325846 213064 at Nuclear receptor coactivator 2 NCOA2 S.446678 242369 x a Nuclear receptor coactivator 2 / Nuclear receptor NCOA2 S.446678 212867 at coactivator 2 nuclear receptor coactivator 3 NCOA3 S.3821.68 207700 s a nuclear receptor coactivator 4 NCOA4 S.S22932 210774 S a nuclear receptor coactivator 6 NCOA6 S.368,971 208979 at nuclear receptor coactivator 6 interacting protein NCOA6IP S.335068 23834.6 s a nuclear receptor coactivator 7 NCOA7 S.171426 225344 at nuclear receptor co-repressor 1 S.462323 200854 at nuclear receptor interacting protein 1 S.1SSO17 202600 s a nuclear receptor interacting protein 3 S.S23467 219557 is a nuclear receptor subfamily 2, group C, member 2 S.549074 206038 s a nuclear receptor subfamily 3, group C, member 1 S.122926 201865 x a (glucocorticoid receptor) Nuclear receptor subfamily 3, group C, member 1 S.122926 232431 at (glucocorticoid receptor) nuclear receptor subfamily 3, group C, member 1 S.122926 211671 s at (glucocorticoid receptor) i? nuclear receptor Subfamily 3, group C, member 1 (glucocorticoid receptor) Nuclear receptor subfamily 3, group C, member 2 S.163924 239673 at Nuclear receptor subfamily 4, group A, member 2 S.165258 235.739 at nuclear RNA export factor 1 S.S23739 208922 s a nuclear RNA export factor 2 S.S3O358 220981 X a nuclear transcription factor Y, alpha S.10441 204109 s a Nuclear transcription factor Y. gamma S.233458 241630 at nuclear transport factor 2 S.356,630 202397 at nuclear ubiquitous casein kinase and cyclin S.213061 217802 s a dependent kinase substrate nuclear ubiquitous casein kinase and cyclin NUCKS S.213061 229353 S a dependent kinase substrate nucleobindin 2 NUCB2 S.128,686 203675 at nucleolar and coiled-body phosphoprotein 1 NOLC1 S.S23238 205895 S a nucleolar and coiled-body phosphoprotein 1 NOLC1 S.S23238 211951 at nucleolar and spindle associated protein 1 NUSAP1 S.S11093 218039 at Nucleolar protein 4 NOL4 S.546,322 238605 at nucleolin NCL S.7911O 200610 s a nucleophosmin (nucleolar phosphoprotein B23, NPM1 S.5.19452 200063 s a numatrin) i? nucleophosmin (nucleolar phosphoprotein B23, numatrin) nucleophosmin (nucleolar phosphoprotein B23, NPM1 S.5.19452 221691 x a numatrin) i? nucleophosmin (nucleolar phosphoprotein B23, numatrin) nucleoporin 133 kDa NUP133 S.12457 202184 S a nucleoporin 153 kDa NUP153 S.121088 1559064 at nucleoporin 153 kDa NUP153 S.121088 202097 at nucleoporin 155 kDa NUP155 S.481.942 206550 S a nucleoporin 210 kDa-like NUP21OL S.67639 232598 at nucleoporin 214 kDa NUP214 S.461860 202155 s a nucleoporin 35 kDa NUP35 S.180591 225470 at nucleoporin 50 kDa NUPSO S.475103 213682 at nucleoporin 50 kDa NUPSO S.475103 218294 S a nucleoporin 98 kDa NUP98 S.S247SO 203194 s a nucleoporin like 2 NUPL2 S.408241 204003 s a nucleoredoxin NXN S.S2.7989 21948.9 s a nucleosome assembly protein 1-like 1 NAP1L1 S.S24599 204528 s a nucleosome assembly protein 1-like 1 NAP1L1 S.S24599 208752 x a nucleosome assembly protein 1-like 1 NAP1L1 S.S24599 208753 s a nucleosome assembly protein 1-like 1 NAP1L1 S.S24599 208754 S a nucleosome assembly protein 1-like 1 NAP1L1 S.S24599 212967 x a nucleosome assembly protein 1-like 1 NAP1L1 S.S24599 213864 S a NudC domain containing 3 NUDCD3 S.488171 201270 x a NudC domain containing 3 KIAA1068 S.488171 242696 at US 2006/01992.04 A1 Sep. 7, 2006 71

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID nudE nuclear distribution gene E homolog like 1 NDEL1 S.372123 208093 s at (A. nidulans) i? nudE nuclear distribution gene E homolog like 1 (A. nidians) nudix (nucleoside diphosphate linked moiety X)- NUDT10 S.375178 241596 at type motif 10 nudix (nucleoside diphosphate linked moiety X)- NUDT4 S.S.0632S 206302 s at type motif 4 nudix (nucleoside diphosphate linked moiety X)- NUDT4 S.S.0632S 212181s at type motif 4 Numb homolog (Drosophila)-like NUMBL S.326953 242.195 x at nurim (nuclear envelope membrane protein) S.S19993 225592 at NYD-SP11 protein S.326745 224135 at NY-REN-58 antigen S.2792.09 213241 at 58 OCIA domain containing 1 S.S187SO 232644 x at OCIA domain containing 1 S.S187SO 239748 x at olfactomedin-like 2B S.507515 213125 at olfactory receptor, family 2, subfamily H, member 1 S.434715 1556986 at olfactory receptor, family 2, subfamily H, member 1 S.434715 1556987 s at Olfactory receptor, family 2, Subfamily H, member 1 S.434715 1567656 at olfactory receptor, family 2, subfamily H, member 1 S.434715 1567657 at olfactory receptor, family 4, subfamily N, member 4 S.S2S666 1560735 S. at Olfactory receptor, family 4, Subfamily N, member 4 S.S2S666 1564855 at Olfactory receptor, family 4, Subfamily N, member 4 S.S2S666 1564856 S at olfactory receptor, family 4, subfamily N, member 4 S.S2S666 1560734 at if olfactory receptor, family 4, Subfamily Q, member 3 olfactory receptor, family 7, Subfamily E, member S.363054 222327 x at 156 pseudogene olfactory receptor, family 7, Subfamily E, member S.404129 216698 x at 47 pseudogene if olfactory receptor, family 7, Subfamily E, member 18 pseudogene i? olfactory receptor, family 7, subfamily E, member 35 pseudogene i? similar to olfactory receptor, family 7, Subfamily A, member 17 OC441453 Oligonucleotidefoligosaccharide-binding fold BFC1 S.134491 240824 a containing 1 oligophrenin 1 PHN1 S.128824 206323 x a OMA1 homolog, Zinc metallopeptidase (S. cerevisiae) MA1 S.425769 226019 a opsin 3 (encephalopsin, panopsin) S.S34399 219032 x a opsin 5 S.213717 233657 a optic atrophy 1 (autosomal dominant) S.4787.08 212213 X a optineurin S.3327O6 202074 s a organic solute transporter alpha S.155932 229230 a. origin recognition complex, Subunit 6 homolog-like S.49760 219105 x a (yeast) ORM1-like 1 (S. cerevisiae) DL1 S.5126OO 2231.87 s a ornithine aminotransferase (gyrate atrophy) S.S23332 201599 a ornithine decarboxylase 1 S.4677O1 200790 a ornithine decarboxylase antizyme 3 O R. S.4O7882 222075 s a Ornithine decarboxylase antizyme inhibitor OAZIN S.4591 O6 240231 a osteopetrosis associated transmembrane protein 1 OSTM1 S.22678O 218196 a OTU domain, ubiquitin aldehyde binding 1 OTUB1 S473788 201245 s a OTU domain, ubiquitin aldehyde binding 1 OTUB1 S473788 38710 at outer dense fiber of sperm tails 1 ODF S.1592.74 214485 a outer dense fiber of sperm tails 2 ODF2 S.1290SS 210415 s a ovostatin 2 OVOS2 S.S243.31 22824.5 s a oxidation resistance 1 OXR S.148778 218197 s a oxidation resistance 1 OXR S.148778 223879 s a oxidised low density lipoprotein (lectin-like) OLR S.412484 21.0004 at receptor 1 oxysterol binding protein OSBP S.SO2688 1563051 at oxysterol binding protein OSBP S.SO2688 201800 s a Oxysterol binding protein 2 OSBP2 S.S17546 23.9872 at oxysterol binding protein-like 8 OSBPL8 S.43O849 212582 at oxysterol binding protein-like 9 OSBPL9 S.21938 218047 at oxytocin receptor OXTR S.282O 206825 at p10-binding protein Cep70 S.531962 224150 s at p21 (CDKN1A)-activated kinase 2 PAK2 S.S18530 244268 x at US 2006/01992.04 A1 Sep. 7, 2006 72

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID p21/Cdc42, Rac1-activated kinase 1 (STE20 PAK1 S.435714 230100 x at homolog, yeast) p53-inducible cell-survival factor S.69499 21.8403 a p8 protein (candidate of metastasis 1) S.513463 209230 s at PAI-1 mRNA-binding protein PAI S.53O412 20966.9 s at RBP1 PAI-1 mRNA-binding protein PAI 217724 a RBP1 paired box gene 2 PAX2 S.155644 206228 a paired box gene 8 PAX8 S.469.728 121 at palladin KIAAO992 S.151220 200897 s at Palladin KIAAO992 S.151220 234135 x at pallidin homolog (mouse) PLDN S.7037 224892 a Pantothenate kinase 1 PANK1 S.465933 228717 a PAP associated domain containing 1 PAPD1 S.173946 233873 X at pappalysin 2 pappalysin 2 PAPPA2 S.187284 211918 x at Par-3 partitioning defective 3 homolog (C. elegans) PARD3 S.131489 1556105 at par-6 partitioning defective 6 homolog alpha PARD6A S.112933 205245 a. (C. elegans) paraneoplastic antigen MA1 PNMA1 S.194709 218224 a paraspeckle component 1 PSPC1 S.213 198 218371 s at PARK2 co-regulated PACRG S.25791 243122 a Parkinson disease (autosomal recessive, early PARK7 S.41964O 200006 a onset) 7 Parkinson disease (autosomal recessive, early onset) 7 patched homolog (Drosophila) PTCH S.494.538 1555520 at paternally expressed 3 PEG3 S.2O1776 209242 a PAX interacting (with transcription-activation S.443881 212825 a. domain) protein 1 PBX knotted 1 homeobox2 KNOX2 S.278564 63305 at PCTAIRE protein kinase 2 K2 S.506415 243993 a PDZ and LIM domain 1 (elfin) S.36852S 208.690 s at PDZ and LIM domain 5 S.480311 212412 a PDZ binding kinase S.104741 219148 a PDZ domain containing 3 S.481819 209493 a PDZ domain containing 8 K 8 S.5O1149 225829 a PDZ domain containing 8 ; KK83 S.5O1149 225830 a. pecanex homolog (Drosophila) S.158722 215175 a PEF protein with a long N-terminal hydrophobic EFCNXLIN S.470417 217923 a domain Pellino homolog 1 (Drosophila) S.7886 232213 a peptidylprolyl isomerase (cyclophilin)-like 1 S.27693 222500 a peptidylprolyl isomerase (cyclophilin)-like 5 : S.451O90 235113 a peptidylprolyl isomerase A (cyclophilin A) S.356331 201293 x a peptidylprolyl isomerase A (cyclophilin A) S.356331 211378 x a peptidylprolyl isomerase A (cyclophilin A) S.356331 211978 x a peptidylprolyl isomerase A (cyclophilin A) S.356331 212661 X a peptidylprolyl isomerase A (cyclophilin A) S.356331 211765 x a peptidylprolyl isomerase A (cyclophilin A) peptidylprolyl isomerase C (cyclophilin C) S.110364 204517 at peptidylprolyl isomerase D (cyclophilin D) S.183958 20418.5 x a pericentriolar material 1 S.491.148 209997 X a Pericentriolar material 1 S.491.148 233270 x a period homolog 1 (Drosophila) S.445534 36829 at period homolog 2 (Drosophila) S.S8756 205251 a peroxiredoxin 2 S.4321.21 215067 x a peroxiredoxin 3 S.S233O2 209766 a peroxiredoxin 4 D X4 S.83383 201923 a peroxiredoxin 6 S.120 200845 s a Peroxisomal acyl-CoA thioesterase S.444,776 236514 a peroxisomal biogenesis factor 11B S.SO4284 202658 a peroxisomal biogenesis factor 16 S.100915 49878 at peroxisomal biogenesis factor 3 s.7277 203972 s a peroxisomal biogenesis factor 5 S.479944 203244 a peroxisomal biogenesis factor 7 if peroxisomal S.280932 211033 s a biogenesis factor 7 peroxisomal D3, D2-enoyl-CoA isomerase S.152SO 218025 s a Peroxisomal Ion protease S.SS1565 221834 a peroxisomal trans-2-enoyl-CoA reductase S.281 68O 223619 x a peroxisomal, testis specific 1 S.S2O097 1552599 at peroxisome biogenesis factor 13 S.336219 205246 a US 2006/01992.04 A1 Sep. 7, 2006 73

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID ERP, TP53 apoptosis effector ERP S.520421 222392 x at FTAIRE protein kinase 1 FTK1 S.430742 204604 at FTAIRE protein kinase 1 FTK1 S.430742 211502 s at HD finger protein 1 HF1 S.166204 40446 at HD finger protein 10 HF10 S.435933 219126 at HD finger protein 10 HF10 S.435933 221786 at HD finger protein 13 HF13 S.S16079 22500S at HD finger protein 2 F2 S.211441 212726 at HD finger protein 20 HF2O S.517044 206,567 s a HD finger protein 20-like 1 HF2OL1 S.3O4362 222133 s a HD finger protein 20-like 1 HF2OL1 S.3O4362 227523 s a HD finger protein 7 HF7 S.372719 215622 x a HD finger protein 7 HF7 S.372719 221611 s a HD finger protein 7 HF7 S.372719 221930 at hosducin-like 3 i? hypothetical protein FLJ12205 DCL3 S.4492O6 219043 s a

LOC285359 phosphatase and actin regulator 2 PHACTR2 S.1O2471 204049 s a Phosphatase and actin regulator 4 PHACTR4 S.225641 233319 x a phosphatase and tensin homolog (mutated in PTEN S.500466 204053 x a multiple advanced cancers 1) Phosphatase and tensin homolog (mutated in PTEN S.500466 225363 at multiple advanced cancers 1) phosphatase and tensin homolog (mutated in PTENP1 S.493716 217492 s a multiple advanced cancers 1), pseudogene 1 phosphatidic acid phosphatase type 2 domain LOC4O3313 S.107510 227385 at containing 2 phosphatidic acid phosphatase type 2A PPAP2A S.435122 210946 at Phosphatidic acid phosphatase type 2B PPAP2B S.405156 232324 x at hosphatidylinositol 4-kinase, catalytic, alpha PIK4CA S.448225 213408 s at polypeptide i? hypothetical protein LOC220686 LOC22O686 Phosphatidylinositol binding clathrin assembly PICALM S.163893 239102 s at rotein hosphatidylinositol glycan, class A (paroxysmal PIGA S.1371.54 205281 s at OC tu l 8. hemoglobinuria) phosphatidylinositol ycan, class A (paroxysmal nocturnal emoglobinuria) 8. inosi glycan, class B GB S.126115 205452 a 8. inosi glycan, class B GB S.126115 214152 a l O S 8. inosi glycan, class C GC S.188456 20284.6 s at 8. inosi glycan, class C GC S.188456 216593 s at 8. inosi glycan, class F GF S.468415 205077 s at 8. inosi glycan, class F GF S.468415 205078 a 8. inosi glycan, class L GL S.167559 205873 a 8. inosi glycan, class V GV S.259605 51146 at 8. inosi transfer protein, alpha TPNA S.4298.19 201192 s at 8. inosi transfer protein, beta TPNB S.7370 202522 a 8. inosi transfer protein, beta TPNB S.7370 244826 a 8. inosi -4-phosphate 5-kinase, type I, PSK1B S.S34371 205632 s at

hosphatidylinositol-4-phosphate 5-kinase, type II, C 205570 a

phatidylserine receptor TDSR S.S14SOS 212723 a l O S phatidylserine synthase 1 TDSS1 S.292579 201433 s at phodiesterase 10A DE10A S.487129 211171 s at phodiesterase 1A, calmodulin-dependent DE1A S.416061 208396 s at hosphodiesterase 1C, calmodulin-dependent DE1C S.487897 207303 a 0 kDaD hodiesterase 4B, cAMP-specific PDE4B S.198072 211302 s at (phosphodiesterase E4 dunce homolog, Drosophila) phosphodiesterase 4C, cAMP-specific S.437211 206792 x at (phosphodiesterase E1 dunce homolog, Drosophila) Phosphodiesterase 4D interacting protein PDE4DIP S.48792S 244511 at (myomegalin) hosphofructokinase, muscle S.75160 210976 s at hosphofructokinase, platelet S.26010 201037 at hosphofurin acidic cluster sorting protein 1 PACS1 S.S36275 224658 x at hosphoglucomutase 2 PGM2 S.23363 225.366 at US 2006/01992.04 A1 Sep. 7, 2006 74

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID

OS) hoglucomutase 2-like 1 S.26612 229553 at OS) hoglycerate kinase 1 S.78771 200738 S at OS) hoglycerate kinase 2 S.367727 217009 at OS) hoglycerate mutase 1 (brain) S.447492 20088.6 s at OS) hohistidine phosphatase 1 S.4O9834 223207 x at PhoSp hoinositide-3-kinase, class 2, alpha S.175343 241905 at polypeptide OS) hoinositide-3-kinase, regulatory Subunit 1 S.132225 212239 at (p85 alpha) OS) hoinositide-3-kinase, regulatory Subunit 1 S.132225 212240 S at (p85 alpha) OS) hoinositide-3-kinase, regulatory Subunit 5, S.2789.01 220566 at holamban PLN S.170839 204938 s at holipase A2, group VI (cytosolic, calcium PLA2G6 S.170479 210647 x at independent) holipase C, beta 1 (phosphoinositide PLCB1 S.310537 244726 a

holipase C, beta 4 PLCB4 S.472101 203895 a holipase C, beta 4 S.472101 240728 a holipase C, gamma 2 (phosphatidylinositol S.413111 204613 a specific) holipase C, Zeta 1 LCZ1 S.97S42 231425 a. holipid scramblase 2 LSCR2 S.1473OS 207374 a honoformate immuno-associated protein 5 FAAPS S.SOf 680 221899 a hoprotein enriched in astrocytes 15 EA15 S.S17216 200787 s at hoprotein enriched in astrocytes 15 EA15 S.S17216 200788 S at horibosyl pyrophosphate synthetase 1 RPS1 S.56 2094.40 a horibosyl pyrophosphate synthetase RPSAP1 S.77498 202529 a associated protein 1 horibosylglycinamide formyltransferase, GART S.473648 230097 a horibosylglycinamide synthetase, horibosylaminoimidazole synthetase horylase kinase, beta PHKB S.78060 202738 s at hoserine aminotransferase 1 PSAT1 S.494.261 223.062 s at hytanoyl-CoA hydroxylase (Refsum disease) PHYH S.498.732 203335 a. hytanoyl-CoA hydroxylase interacting protein-like PHYHIPL S.499.704 226623 a hytoceramidase, alkaline PHCA S.23862 222688 a -3-kinase-related kinase SMG-1 PI-3-kinase SMG1 S.46O179 244766 a related kinase SMG-1-like hLAT1-3TM similar KIAAO220 o PI-3-kinase-related kinase SMG-1 isoform 1: ambd aiota protein kinase C-interacting protein; MAA phosphatidylinositol 3-kinase-related protein LOC440345 kinase i? hypothetica protein LOC440354 LOC440354 PI-3-kinase-related kinase SMG-1-like KIAAO220 S.528462 211996 s at pinin, desmosome associated protein PNN S.409965 1567213 at pinin, desmosome associated protein PNN S.409965 1567214 a at piwi-like 1 (Drosophila) PIWIL1 S.405659 214868 at PLAC 8-like 1 PLAC8L1 S.162369 237783 at Placental growth factor, vascular endothelial PG S.25282O 215179 X at growth factor-related protein plakophilin 4 S.407580 201928 at Plakophilin 4 S.407580 236752 at plasminogen-like B1 S.4241.84 205871 at platelet-activating factor acetylhydrolase, isoform S.77318 200815 s at b, alpha subunit 45 kDa platelet-activating factor acetylhydrolase, isoform S.1885O1 224777 s at b, beta subunit 30 kDa plecks rin and Sect domain containing 3 PSD3 S.434255 203355 S at plecks rin homology domain containing, family A PLEKHA3 S.41086 223370 at (phosphoinositide binding specific) member 3 plecks rin homology domain containing, family A PLEKHA3 S.41086 227658 s at (phosphoinositide binding specific) member 3 plecks rin homology domain containing, family A PLEKHAS S.188.614 220952 s at memb er 5 Pleckstrin homology domain containing, family A PLEKHAS S.188.614 237483 at memb er 5 Pleckstrin homology domain containing, family A PLEKHA6 S.253.146 238134 at memb er 6 US 2006/01992.04 A1 Sep. 7, 2006 75

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID pleckstrin homology domain containing, family B PLEKHB1 S.445489 2095.04 S at (evectins) member 1 Pleckstrin homology domain containing, family B PLEKHB2 S.469944 201410 at (evectins) member 2 pleckstrin homology domain containing, family J PLEKHJ1 S.SO1353 218290 at member 1 pleckstrin homology, Sect and coiled-coil domains PSCD2 S.8517 209158 s a 2 (cytohesin-2) pleckstrin homology-like domain, family A, member 2 PHILDA2 S.14036 209802 at pleckstrin homology-like domain, family A, member 2 PHILDA2 S.154036 2098.03 s a pleiomorphic adenoma gene-like 2 PLAGL2 S.154104 202924 S a PMS1 postmeiotic segregation increased 1 (S. cerevisiae) PMS1 S.111749 213677 s a PNAS-13 LOC441212 S.292O57 22394.5 x a Poliovirus receptor-related 3 PVRL3 S.2939.17 222167 at Poliovirus receptor-related 3 PVRL3 S.2939.17 241970 at poly (ADP-ribose) polymerase family, member 1 PARP1 S.177766 208.644 at poly (ADP-ribose) polymerase family, member 2 PARP2 S.4O9412 215773 X a poly (ADP-ribose) polymerase family, member 6 PARP6 S.270244 2196.39 x a Poly (ADP-ribose) polymerase family, member 9 PARP9 S.5182OO 227807 at poly(A) binding protein interacting protein 2 PAIP2 S.396644 222983 s a poly(A) binding protein, cytoplasmic 1 PABPC1 S.387804 21515.7 x a poly(A) binding protein, cytoplasmic 3 if poly(A) PABPC3 S.387804 215823 x a binding protein, cytoplasmic 1 if similar to Polyadenylate-binding protein 1 (Poly(A)-binding PABPC1 protein 1) (PABP 1) LOC341315 poly(A) binding protein, cytoplasmic 3 if poly(A) PABPC3 S.45828O 208113 x at binding protein, cytoplasmic 3 poly(A) binding protein, nuclear 1 PABPN1 S.1171.76 201544 x at poly(A) binding protein, nuclear 1 PABPN1 S.1171.76 213046 a poly(A) polymerase alpha PAPOLA S.253726 209388 a poly(A) polymerase alpha PAPOLA S.253726 212718 a poly(A) polymerase alpha PAPOLA S.253726 228569 a poly(A) polymerase beta (testis specific) PAPOLB S.4874O9 2421.58 a poly(A) polymerase gamma PAPOLG S.146123 222839 s at poly(A)-specific ribonuclease (deadenylation PARN S.2531.97 203905 a nuclease) Poly(rC) binding protein 2 PCBP2 S.546271 213517 a polyamine oxidase (exo-N4-amino) PAOX S.532469 221941 a polyamine oxidase (exo-N4-amino) PAOX S.532469 50400 at polybromo 1 PB S.18992O 220355 s at Polycomb group ring finger 3 PCGF3 S.144309 243329 a polycomb group ring finger 4 PCGF4 S.380403 202265 a polycomb group ring finger 5 PCGF5 S.SOOS12 227935 S. at polycomb group ring finger 6 if polycomb group PCGF6 S.335808 224326 s at ring finger 6 Polycystic kidney disease 1 (autosomal dominant) PKD S.75813 241090 a polyhomeotic-like 1 (Drosophila) PHC S.305985 225958 a polyhomeotic-like 2 (Drosophila) PHC2 S.524271 200919 a polymerase (DNA directed) sigma POLS S.481542 202466 a polymerase (DNA directed), beta POL S.S21 S63 2036.16 a Polymerase (DNA directed), epsilon POL S.524871 15605.09 at polymerase (DNA directed), epsilon 3 (p17 POL S.108112 208.828 a Subunit) Polymerase (DNA directed), eta POLH S.439153 1557700 at polymerase (DNA directed), eta POLH S.439153 219380 x at polymerase (DNA-directed), delta interacting POLDIP2 S.241543 217806 s at protein 2 polymerase (RNA) I polypeptide B, 128 kDa POLR1B S.86337 22O113 x at polymerase (RNA) I polypeptide B, 128 kDa POLR1B S.86337 223403 s at polymerase (RNA) I polypeptide B, 128 kDa POLR1B S.86337 233341 s at polymerase (RNA) I polypeptide C, 30 kDa POLR1C S.52014.6 209317 at polymerase (RNA) II (DNA directed) polypeptide B, POLR2B S.479814 1555837 S at 140 kDa polymerase (RNA) II (DNA directed) polypeptide B, POLR2B S.479814 201803 at 140 kDa polymerase (RNA) II (DNA directed) polypeptide C, POLR2C 216282 x at 33 kDa polymerase (RNA) II (DNA directed) polypeptide D POLR2D S.444887 203664 S at polymerase (RNA) II (DNA directed) polypeptide H POLR2EH S.432574 209302 at US 2006/01 99204 A1 Sep. 7, 2006 76

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID polymerase (RNA) III (DNA directed) polypeptide C POLR3C S.SSOSO1 2105.73 s at (62 kD) polymerase (RNA) III (DNA directed) polypeptide E POLR3E 218016 s at (80 kD) polymerase (RNA) III (DNA directed) polypeptide G POLR3GL HS.9088 223269 at (32 kD) like Polypyrimidine tract binding protein 2 PTBP2 S.269895 1560271 at POM121 membrane glycoprotein (rat) f/f nuclear POM121 S.488.624 212178 s at envelope pore membrane LOC340318 LOC34.0318 POM121-like protein DKFZP434P211 S.328458 222253 s at postmeiotic segregation increased 2-like 1 PMS2L1 S.520575 214756 x at postmeiotic segregation increased 2-like 1 PMS2L1 S.520575 216843 x at postmeiotic segregation increased 2-like 1 PMS2L1 S.520575 217485 x at postmeiotic segregation increased 2-like 2 PMS2L2 S.292996 215412 x at Postmeiotic segregation increased 2-like 3 PMS2L3 S.S49057 214473 x at Postmeiotic segregation increased 2-like 3 PMS2L3 S.S49057 216525 x at postmeiotic segregation increased 2-like 5 PMS2L5 S.397073 213893 x at potassium channel modulatory factor 1 KCMF1 S.345 694 21793.8 s at potassium channel regulator KCNRG S.S.08O3S 240288 a potassium channel tetramerisation domain KCTD10 S.S24731 223208 a containing 10 Potassium channel tetramerisation domain KCTD13 S.S34590 238142 a containing 13 potassium channel, Subfamily K, member 4 KCNK4 S.971.74 219883 a potassium channel, Subfamily V, member 2 KCNV2 S.131130 217522 a. potassium inwardly-rectifying channel, Subfamily J, KCN14 S.144011 220776 a member 14 potassium large conductance calcium-activated KCNMB4 219287 a channel, subfamily M, beta member 4 potassium voltage-gated channel, Subfamily H KCNH7 S.470445 224099 a (eag-related), member 7 POU domain, class 3, transcription factor 3 POU3F3 S.248.158 228780 a PPAR binding protein PPARBP S.462956 203497 a PQ loop repeat containing 1 PQLC1 S.288284 218208 a PR domain containing 10 PRDM10 S.27SO86 219515 a. PR domain containing 2, with ZNF domain PRDM2 S.371823 205277 a PR domain containing 4 PRDM4 S.S.066SS 494.85 at PR domain containing 5 PRDMS S.132593 220792 a Prader-Willi/Angelman region-1 PAR1 S.546847 226587 a praja 1 PJA1 S.S22679 218667 a praja 2, RING-H2 motif containing PJA2 S.483O36 201133 s a pre-B-cell colony enhancing factor 1 PBEF1 S.4896.15 217738 a pre-B-cell colony enhancing factor 1 PBEF1 S.4896.15 217739 S a Pre-B-cell leukemia transcription factor 1 PBX1 S.493.096 1562235 s at Pre-B-cell leukemia transcription factor 1 PBX1 S.493.096 212151 a pre-B-cell leukemia transcription factor 3 PBX3 S.428O27 204082 a pre-B-cell leukemia transcription factor interacting PBXIP1 S.SOS806 212259 s a protein 1 PREDICTED: Homo sapiens olfactory receptor, S.SOf861 217499 x a amily 7, Subfamily E, member 31 pseudogene (OR7E31P), mRNA pregnancy specific beta-1-glycoprotein 3 if PSG3 S.466843 211741 X a pregnancy specific beta-1-glycoprotein 3 pregnancy specific beta-1-glycoprotein 6 PSG6 S.466849 208106 X a pregnancy-associated plasma protein A, PAPPA S.494928 224940 S a pappalysin 1 pregnancy-associated plasma protein A, PAPPA S.494928 228128 x a pappalysin 1 pregnancy-Zone protein PZP S.480.143 207330 at pre-mRNA cleavage complex II protein Pcf11 PCF11 S.128959 227622 at presenilin 1 (Alzheimer disease 3) PSEN1 HS.3260 203460 S a prickle-like 1 (Drosophila) PRICKLE1 S.S24348 226065 at PROO149 protein PROO149 S.221497 1568954 s at PROO149 protein PROO149 S.221497 2251.83 at PROO149 protein PROO149 S.221497 225197 at PROO611 protein PUM1 S.281707 241079 at PRO1073 protein PRO1073 223577 x at PRO1073 protein PRO1073 231735 S. at PRO1550 S.371588 1556543 at PRO1550 S.371588 230332 at US 2006/01992.04 A1 Sep. 7, 2006 77

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID PRO1550 S.371588 234032 at procollagen (type III) N-endopeptidase PCOLN3 S.461777 201933 at procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 PLOD3 S.153357 202185 at profilin 2 PFN2 S.91747 204992 s at Profilin 2 PFN2 S.91747 2371.16 at profilin family, member 4 PFN4 S.442718 235627 at progestin and adipoCR receptor family member III PAQR3 S.3683OS 1557576 at progestin and adipoCR receptor family member III PAQR3 S.3683OS 21.3372 at programmed cell death 10 PDCD10 S.4781SO 210907 s at programmed cell death 2 PDCD2 S.367900 228420 at programmed cell death 4 (neoplastic PDCD4 S.232543 202731 at transformation inhibitor) programmed cell death 6 ft, aryl-hydrocarbon PDCD6 S.S.08.23 229354 at receptor repressor if AHRR programmed cell death 6 hypothetical gene PDCD6 S.51841O 1568763 s at supported by AKO55127: BC053586; BC06.7863 LOC44O997 programmed cell death 6 interacting protein PDCD6IP S.475896 217746 s at projection protein PF6 PF6 S.5288.21 233516 s at prokineticin 1 PROK1 S.S.14793 229124 at prolactin PRL S.1905 205445 at proliferating cell nuclear antigen PCNA S.147433 201202 at Proline rich Gla (G-carboxyglutamic acid) 4 PRRG4 S.471695 238,513 at (transmembrane) proline-rich cyclin A1-interacting protein PROCA1 S.207471 232647 at proline-rich nuclear receptor coactivator 2 PNRC2 S.7862 217779 s a proline-rich protein BstNI subfamily 1 i? proline-rich PRB1 if S.283658 210597 X a protein BstNI subfamily 2 PRB2 pro-melanin-concentrating hormone-like 1 if pro- PMCHL1 S.247975 224418. X a melanin-concentrating hormone-like 1 pro-melanin-concentrating hormone-like 1 if pro- PMCHL1 S.247975 224419 x a melanin-concentrating hormone-like 1 prominin 1 PROM1 S.479220 204304 S a pro-oncosis receptor inducing membrane injury PORIMIN S.SO3709 211967 at gene propionyl Coenzyme A carboxylase, beta PCCB S.63788 212694 S a polypeptide proprotein convertase subtilisin?kexin type 5 PCSKS S.368542 205559 is a Prostate tumor overexpressed gene 1 PTOV1 S.S15540 240615 at prostatic binding protein PBP S.43.3863 210825 s a protamine 1 PRM1 S.2909 206358 at protamine 2 PRM2 S.2324 21.0122 at protease, serine, 22 PRSS22 S.459709 205847 at proteasome (prosome, macropain) 26S subunit, PSMC2 S.437366 201068 s a ATPase, 2 proteasome (prosome, macropain) 26S subunit, PSMD1 S.3887 201198 s a non-ATPase, 1 proteasome (prosome, macropain) 26S subunit, PSMD12 S.4295 202352 s a non-ATPase, 12 proteasome (prosome, macropain) activator PSME4 S.4138O1 212220 a subunit 4 proteasome (prosome, macropain) activator PSME4 S.4138O1 212222 a subunit 4 Proteasome (prosome, macropain) activator PSME4 237180 a subunit 4 proteasome (prosome, macropain) inhibitor Subunit PSMF1 S.471917 201053 s at (PI31) Proteasome (prosome, macropain) inhibitor PSMF1 S.471917 235993 a subunit 1 (PI31) proteasome (prosome, macropain) subunit, alpha PSMA4 S.251531 203396 a type, 4 proteasome (prosome, macropain) subunit, alpha PSMA6 S.446260 208805 a type, 6 proteasome (prosome, macropain) subunit, beta PSMB1 S.352768 214288 s at type, 1 proteasome (prosome, macropain) subunit, beta PSMB5 S.422990 208799 a type, 5 proteasome regulatory particle subunit p44S10 44S10 S.152536 202753 a. protein (peptidyl-prolyl cis/trans isomerase) NIMA- PIN4 S.118076 204571 x at interacting, 4 (parvulin) US 2006/01992.04 A1 Sep. 7, 2006 78

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID protein (peptidyl-prolyl cis/trans isomerase) NIMA- PIN4 S.118076 204572 s at interacting, 4 (parvulin) protein (peptidyl-prolyl cis/trans isomerase) NIMA- PIN4 S.118076 214224 S at interacting, 4 (parvulin) protein 7 transactivated by hepatitis B virus X XTP7 s.337557 15.52889 a. at antigen (HBXAg) protein disulfide isomerase-associated 5 PDIAS S.477352 203857 s at protein disulfide isomerase-associated 6 PDIA6 S.2121 O2 2O7668 X at protein disulfide isomerase-associated 6 PDIA6 S.2121 O2 208.639 X at Protein geranylgeranyltransferase type I, beta PGGT1B S.254OO6 242844 at Subunit Protein inhibitor of activated STAT, 1 PIAS1 S.162458 222371 at protein inhibitor of activated STAT, 2 PIAS2 S.514846 1555514 a at Protein inhibitor of activated STAT, 2 PIAS2 S.514846 244633 at protein kinase C and casein kinase Substrate in PACSIN2 S.162877 1554691 a. at neurons 2 protein kinase C binding protein 1 PRKCBP1 S.446240 230533 at protein kinase C, beta 1 PRKCB1 S.4603SS 209685 s at Protein kinase C, eta PRKCH S.333907 1559425 at protein kinase C, iota PRKCI S.3998.73 209678 s at protein kinase D3 i? protein kinase D3 PRKD3 S.173536 211084 x at protein kinase LYK5 LYK5 S.549229 52169 at protein kinase N2 PKN2 S.44.0833 212629 s at protein kinase NYD-SP25 NYD S.3S1815 231554 at SP25 protein kinase NYD-SP25 NYD S.3S1815 240051 at SP25 protein kinase, AMP-activated, gamma 2 non- PRKAG2 S.549162 218292 S at catalytic subunit protein kinase, AMP-activated, gamma 2 non- PRKAG2 S.549162 233748 x at catalytic subunit protein kinase, cAMP-dependent, regulatory, type PRKAR1A S.28O342 200604 S at , alpha (tissue specific extinguisher 1) protein kinase, cAMP-dependent, regulatory, type PRKAR1A S.28O342 200605 s at , alpha (tissue specific extinguisher 1) protein kinase, cAMP-dependent, regulatory, type PRKAR2A S.517841 204842 x at I, alpha Protein kinase, cAMP-dependent, regulatory, type PRKAR2A S.517841 225O11 a I, alpha Protein kinase, interferon-inducible double PRKRA S4OSS37 244047 a stranded RNA dependent activator protein O-fucosyltransferase 2 POFUT2 S.S17345 209578. S. at protein phosphatase 1, catalytic subunit, beta PPP1CB S.468O18 201408 a isoform protein phosphatase 1, catalytic subunit, gamma PPP1CC S.79081 200726 a isoform protein phosphatase 1, regulatory (inhibitor) PPP1R11 S.82887 201500 s at subunit 11 protein phosphatase 1, regulatory (inhibitor) PPP1R2 S.184840 20216S a subunit 2 protein phosphatase 1, regulatory (inhibitor) PPP1R2 S.184840 202166 s at subunit 2 protein phosphatase 1, regulatory (inhibitor) PPP1R2P9 S.127689 207377 a Subunit 2 pseudogene 9 protein phosphatase 1, regulatory (inhibitor) PPP1R9A S.48916O 221088 s at subunit 9A Protein phosphatase 1, regulatory subunit 7 PPP1Rf S.36587 1559054 a at protein phosphatase 1, regulatory subunit 7 PPP1Rf S.36587 201214 S at Protein phosphatase 1A (formerly 2C), PPM1A 231370 at magnesium-dependent, alpha isoform protein phosphatase 1A (formerly 2C), PPM1A S.130O36 203966 s at magnesium-dependent, alpha isoform protein phosphatase 1A (formerly 2C), magnesium dependent, alpha isoform protein phosphatase 1B (formerly 2C), PPM1B S.416769 209296 at magnesium-dependent, beta isoform protein phosphatase 1G (formerly 2C), PPM1G S.17883 200913 at magnesium-dependent, gamma isoform protein phosphatase 1-J (PP2C domain containing) PPM1.J. s.179735 229484 at Protein phosphatase 2 (formerly 2A), catalytic PPP2CA S.4834.08 215628 x at Subunit, alpha isoform US 2006/01992.04 A1 Sep. 7, 2006 79

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID protein phosphatase 2 (formerly 2A), regulatory PPP2R2A HS.146339 202313 at subunit B (PR 52), alpha isoform protein phosphatase 2 (formerly 2A), regulatory PPP2R2A HS.146339 236492 at subunit B (PR 52), alpha isoform protein phosphatase 2 (formerly 2A), regulatory PPP2R2B HS.1938.25 213849 s at subunit B (PR 52), beta isoform protein phosphatase 2 (formerly 2A), regulatory PPP2R3A HS.S1815S 2077.49 s at subunit B", alpha protein phosphatase 2, regulatory subunit B (B56), PPP2RSD HS.S333O8 202513 s at delta isoform protein phosphatase 2, regulatory subunit B (B56), PPP2RSD HS.S333O8 211159 s at delta isoform protein phosphatase 2, regulatory subunit B (B56), PPP2RSE HS.334.868 203338 at epsilon isoform Protein phosphatase 2, regulatory subunit B (B56), PPP2RSE HS.334.868 228070 at epsilon isoform protein phosphatase 2, regulatory subunit B (B56), PPP2RSE HS.334.868 229322 at epsilon isoform protein phosphatase 2, regulatory subunit B (B56), PPP2RSC HS.368,264 1557718 at gamma isoform protein phosphatase 2, regulatory subunit B (B56), PPP2RSC HS.368,264 201877 s at gamma isoform Protein phosphatase 3 (formerly 2B), catalytic PPP3CA HS.435512 2296.06 at Subunit, alpha isoform (calcineurin Aalpha) protein phosphatase 3 (formerly 2B), regulatory PPP3R1 HS.280604 204506 at subunit B, 19 kDa, alpha isoform (calcineurin B, type I) Protein phosphatase 3 (formerly 2B), regulatory PPP3R1 HS.280604 241786 at subunit B, 19 kDa, alpha isoform (calcineurin B, type I) protein phosphatase 3 (formerly 2B), regulatory PPP3R2 HS.151167 231304 at subunit B, 19 kDa, beta isoform (calcineurin B, type I) protein phosphatase 4, regulatory subunit PPP4R1 HS.464595 201594 S a protein phosphatase 6, catalytic subunit PPP6C HS.495128 203529 at protein predicted by clone 23733 HSU79274 HS.4366.18 204521 at protein regulator of cytokinesis 1 PRC1 HS.4593.62 218009 s a Protein tyrosine phosphatase type IVA, member 1 PTP4A1 Hs.227777 1559322 at protein tyrosine phosphatase type IVA, member 1 PTP4A1 Hs.227777 200730 s a protein tyrosine phosphatase type IVA, member 1 PTP4A1 Hs.227777 200733 s a protein tyrosine phosphatase type IVA, member 2 PTP4A2 HS.470477 208.616 s a protein tyrosine phosphatase type IVA, member 2 PTP4A2 HS.470477 208.617 s a protein tyrosine phosphatase type IVA, member 3 PTP4A3 HS.436.66 209695 at protein tyrosine phosphatase, mitochondrial 1 PTPMT1 HS.4295O6 2238.08 s a protein tyrosine phosphatase, non-receptor type 1 PTPN1 HS.417549 202716 at protein tyrosine phosphatase, non-receptor type 11 PTPN11 HSSO6852 205868 s a (Noonan syndrome 1) Protein tyrosine phosphatase, non-receptor type PTPN13 HS.436142 243792 x a 3 (APO-1/CD95 (Fas)-associated phosphatase) protein tyrosine phosphatase, non-receptor type 6 PTPN6 HS.63489 206687 s a protein tyrosine phosphatase, non-receptor type PTPNS1L2 HS.339789 232891 at Substrate 1-like 2 Protein tyrosine phosphatase, receptor type, A VPS16 HS.269577 233313 at protein tyrosine phosphatase, receptor type, f PPFIA1 HS.S30749 210235 s a polypeptide (PTPRF), interacting protein (liprin), alpha 1 protein tyrosine phosphatase, receptor type, f PPFIA1 HS.S30749 210236 at polypeptide (PTPRF), interacting protein (liprin), alpha 1 protein tyrosine phosphatase, receptor type, M PTPRM HS.49774 1555579 s at proteoglycan 1, secretory granule PRG1 HS.1908 201859 at prothymosin, alpha (gene sequence 28) PTMA HS.459927 200772 X at prothymosin, alpha (gene sequence 28) i? PTMA HS.45992S 216515 x at hypothetical gene supported by BCO13859 LOC441454 prothymosin, alpha (gene sequence 28) i? similar PTMA HS.45992S 200773 X at o prothymosin alpha i? hypothetical gene LOC440O85 supported by BCO13859 LOC441454 protocadherin 17 PCDH17 HS.106511 205656 at protocadherin 18 PCDH18 HS.S18989 225975 at protocadherin alpha 9 PCDHA9 208.205 at US 2006/01992.04 A1 Sep. 7, 2006 80

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID protocadherin gamma Subfamily A, 4 PCDHGA4 1552735 at protocadherin LKC PC-LKC S.4205 22O186 s at protoporphyrinogen oxidase PPOX S.517373 238117 at PRP18 pre-mRNA processing factor 18 homolog PRPF18 S.161181 223685 S at (yeast) PRP18 pre-mRNA processing factor 18 homolog PRPF18 S.161181 232473 at (yeast) PRP4 pre-mRNA processing factor 4 homolog B PRPF4B S.159014 202127 at (yeast) prune homolog (Drosophila) PRUNE S.78524 209586 s at prune homolog (Drosophila) PRUNE S.78524 210988 s at PTD012 protein PTDO12 S.836O 229851 s at PTD015 protein S.503357 221600 s at PTEN induced putative kinase 1 S.389171 209019 s at PTK2 protein tyrosine kinase 2 S.395482 1559529 at PTK2 protein tyrosine kinase 2 S.395482 241453 a PTK2 protein tyrosine kinase 2 S.395482 242240 a PTK7 protein tyrosine kinase 7 S.90572 207011 s at PTK9 protein tyrosine kinase 9 S.1890.75 201745 a. PTPRF interacting protein, binding protein 1 (liprin S.172445 1569464 at beta 1) PTX1 protein S.339453 226422 a pumilio homolog 1 (Drosophila) S.281707 201166 s at pumilio homolog 2 (Drosophila) S.467824 216221 S at purinergic receptor P2Y, G-protein coupled, 5 S.123464 218589 a purine-rich element binding protein A S.443121 204020 a purine-rich element binding protein B S.3491SO 226762 a purine-rich element binding protein B S.3491SO 227718 a purine-rich element binding protein G S.373778 235634 a putative acyl-CoA dehydrogenase S.441378 225573 a putative homeodomain transcription factor 1 S.486246 205702 a putative homeodomain transcription factor 1 S.486246 210191 s at putative MAPK activating protein S.209431 1553677 a. at putative membrane protein S.938.32 208716 S at putative neuronal cell adhesion molecule S.512847 232037 a putative nuclear protein ORF1-FL49 S.483.561 224707 a Putative olfactory receptor (clone ht2) S.1298.32 215463 a putative Small membrane protein NID67 S.29444 223276 a putative translation initiation factor S.15058O 211956 S at pyridoxal (pyridoxine, vitamin B6) kinase S.284491 202671 s at pyridoxal (pyridoxine, vitamin B6) kinase S.284491 218018 a pyridoxine 5'-phosphate oxidase S.514278 218511 s at pyruvate dehydrogenase kinase, isoenzyme 1 S.47O633 226452 a Pyruvate dehydrogenase kinase, isoenzyme 3 S.444422 221957 a pyruvate dehydrogenase phosphatase regulatory S.4611.83 220236 a Subunit pyruvate dehydrogenase phosphatase regulatory S.4611.83 224902 a Subunit Pyruvate kinase, muscle S.198.281 213700 S at QIL1 protein S.356626 225823 a Quaking homolog, KH domain RNA binding S.510324 241938 a (mouse) quiescin Q6 S.S18374 2014.82 a Quinolinate phosphoribosyltransferase (nicotinate S.513484 1564129 a. at nucleotide pyrophosphorylase (carboxylating)) R3H domain (binds single-stranded nucleic acids) S.412462 202754 a containing Rab geranylgeranyltransferase, beta subunit RABGGTB S.78948 209180 a RAB GTPase activating protein 1 RABGAP1 S.271341 204028 s at RAB GTPase activating protein 1 RABGAP1 S.271341 213313 a RAB GTPase activating protein 1-like RABGAP1L, S.495391 213982 s at RAB guanine nucleotide exchange factor (GEF) 1 RABGEF1 S.S3OOS3 218310 a RAB interacting factor RABIF S. 90875 204478 s at RAB11 family interacting protein 1 (class I) RAB11FIP1 S.191179 225177 a RAB11 family interacting protein 2 (class I) RAB11FIP2 S.173656 203883 S at RAB11 family interacting protein 3 (class II) RAB11FIP3 S.531642 228613 a RAB11 family interacting protein 5 (class I) RAB11 FIPS S.24557 210879 s at RAB13, member RAS oncogene family RAB13 S.151536 202252 a RAB14, member RAS oncogene family RAB14 S.371 S63 211503 s at RAB18, member RAS oncogene family RAB18 S.406799 229398 a US 2006/01992.04 A1 Sep. 7, 2006 81

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID RA B18, member RAS oncogene family if RAB18, RA B18 S.406799 224377 s at member RAS oncogene family B1A, member RAS oncogene family S.310645 207791 s at B1A, member RAS oncogene family S.310645 208724 S at B1A, member RAS oncogene family S.310645 213440 a B22A, member RAS oncogene family S.529044 237864 a B27A, member RAS oncogene family S.298651 209514 S at B3 GTPase-activating protein S.306327 213530 a. B3 GTPase-activating protein S.306327 213531 s at Ra b 3 GTPase-activating protein, non-catalytic S.549128 202372 a. subunit (150 kD) B31, member RAS oncogene family S.99528 217762 s at B3A interacting protein (rabin3) S.258209 223471 a B40C, member RAS oncogene family S.45963O 1569396 at B5A, member RAS oncogene family S.47S663 209089 a B5B, member RAS oncogene family S.77690 201276 a B6 interacting protein 2 S.400431 1552663 a at B6A, member RAS oncogene family S.SO3222 201047 x at B7, member RAS oncogene family S.15738 211961 s at B8A, member RAS oncogene family HS.S947 208819 a B8E3, member RAS oncogene family S.389733 219210 s at GTPase activating protein 1 S.S.05469 222077 s at D17 homolog (S. pombe) S.16184 207405 s at D17 homolog (S. pombe) S.16184 211228 s at D21 homolog (S. pombe) S.81848 200607 s at D23 homolog B (S. cerevisiae) S.521640 201222 S at D51-like 3 (S. cerevisiae) S.125244 209965 S at D51-like 3 (S. cerevisiae) S.125244 37793 r at D9 homolog A (S. pombe) S.24O457 204.828 at radical S-adenosyl methionine and flavodoxin S.S20917 218347 at domains 1 Radical S-adenosyl methionine and flavodoxin SAFD1 S.S20917 240800 x at domains 1 radical S-adenosyl methionine domain containing 2 RSAD2 S.17518 242625 at RAE1 RNA export 1 homolog (S. pombe) RAE S.371 698 201558 at Ral GEF with PH domain and SH3 binding motif 2 RALGPS2 S.S49173 220338 at ralAbinding protein 1 RALBP1 S.S28993 20284.5 s at RAN binding protein 2 RANBP2 S.199561 201711 X at RAN binding protein 2 RANBP2 S.199561 201713 s at RAN binding protein 2-like 1 RANBP2L1 S.46963O 210676 x at RAN binding protein 2-like 1 RANBP2L1 S.46963O 211324 S at RAN binding protein 2-like 1 RANBP2L1 S.46963O 232511 at RAN binding protein 2-like 1 i? similar to Ran BP2L1 S.46963O 212842 x at binding protein 2 i? similar to RAN-binding protein 2-like 1

LOC375,258 RAN binding protein 5 BP5 S.S13057 211953 s at RAN binding protein 5 BP5 S.S13057 211955 at RAN binding protein 9 RANBP9 S.306.242 202582 s at RAN binding protein 9 BP9 S.306.242 202583 s at RAN binding protein 9 BP9 S.306.242 242143 at RAN binding protein 9 RANBP9 S.306.242 244474 at Ran GTPase activating protein 1 RANGAP1 S.1838OO 212125 at Rap guanine nucleotide exchange factor (GEF) 2 RAPGEF2 S.113912 203096 s at Rap guanine nucleotide exchange factor (GEF) 6 RAPGEF6 239438 at RAP1 interacting factor homolog (yeast) RIF1 S.S36537 241820 at RAP1, GTP-GDP dissociation stimulator 1 RA S.132858 2094.44 at RAP1B, member of RAS oncogene family RA S.36992O 200833 s at rap2 interacting protein X HS.7972 210251 s at RAP2A, member of RAS oncogene family S.50848O 225585 at RAP2B, member of RAS oncogene family S.98.643 213923 at RA-regulated nuclear matrix-associated protein S.126,774 218585 S at RA-regulated nuclear matrix-associated protein S.126,774 22268.0 s at RAR-related orphan receptor A S.S11626 210426 x at RAR-related orphan receptor A S.S11626 210479 s at RAS and EF hand domain containing S.1291.36 1553185 at RAS and EF hand domain containing S.1291.36 1553186 X at Ras association (RalGDSAF-6) and pleckstrin S.471.162 243012 at homology domains 1 Ras homolog enriched in brain S.283521 201453 x at US 2006/01992.04 A1 Sep. 7, 2006 82

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Ras homolog enriched in brain RHEB S.283521 213404 S at Ras homolog enriched in brain RHEB S.283521 213409 s at ras homolog gene family, member A if ras RHOA S.247.077 200059 s at homolog gene family, member A ras homolog gene family, member F (in filopodia) RHOF S.223617 1554538 at ras homolog gene family, member G (rho G) RHOG S.SO1728 203175 at ras homolog gene family, member Q RHOQ S.54912S 212117 at ras homolog gene family, member Q RHOQ S.54912S 212119 at Ras homolog gene family, member Q RHOQ S.54912S 212120 at ras homolog gene family, member T1 RHOT1 S.462742 218323 at ras responsive element binding protein 1 RREB1 S.298.248 215032 at ras responsive element binding protein 1 RREB1 S.298.248 242297 at Ras-associated protein Rap1 RBJ S.434993 223504 at Ras-GTPase activating protein SH3 domain G3BP2 S.3O3676 206383 s at binding protein 2 Ras-GTPase activating protein SH3 domain 208840 S at binding protein 2 Ras-GTPase activating protein SH3 domain 208841 s at binding protein 2 Ras-GTPase-activating protein SH3-domain S.3353 225.007 at binding protein RAS-like, family 11, member A S.1921.31 238353 at Ras-related GTP binding C S.532461 218088 s at RB1-inducible coiled-coil 1 S.1961O2 202033 s at RB1-inducible coiled-coil 1 S.1961O2 237626 at RCD1 required for cell differentiation1 homolog (S. pombe) S.148767 213179 at rearranged L-myc fusion sequence S.205627 204243 at receptor associated protein 80 S.232721 220746 s at recombining binding protein suppressor of hairless S.479396 211974 x at (Drosophila) RecQ protein-like (DNA helicase Q1-like) ECQL S.235.069 212917 x at reelin ELN S.132439 205923 a regenerating islet-derived 3 alpha EG3A S.423 205815 a. regucalcin gene promotor region related protein GPR S.451846 1555289 at regulator of G-protein signalling 22 GS22 S.12OO21 223691 a regulatory factor X, 1 (influences HLA class II FX1 s.73677 226786 a expression) regulatory factor X, 3 (influences HLA class II S.136829 207234 a expression) Regulatory factor X, 3 (influences HLA class II S.136829 217671 a expression) Regulatory factor X, 3 (influences HLA class II S.136829 240867 a expression) regulatory solute carrier protein, family 1, member 1 SC1A1 S.239459 214583 a related RAS viral (r-ras) oncogene homolog 2 RAS2 S.5O2004 212590 a replication protein A1, 70 kDa PA1 S.461925 201529 s at replication protein A2, 32 kDa PA2 S.79411 201756 a Replication protein A3, 14 kDa PA3 S.487540 240601 a RER1 retention in endoplasmic reticulum 1 ER1 S.525527 202296 s at homolog (S. cerevisiae) REST corepressor 1 RCOR1 S.S10521 212612 a REST corepressor 3 RCOR3 S.356399 218344 S at restin (Reed-Steinberg cell-expressed intermediate RSN S.524809 201975 a. filament-associated protein) Restin (Reed-Steinberg cell-expressed RSN S.524809 242287 a intermediate filament-associated protein) restin-like 2 S.122927 219944 a Restin-like 2 S.122927 242710 a ret finger protein 2 S.436922 203659 S at ret finger protein-like 3 S.1677S1 207936 x at ret finger protein-like 3 antisense S.27428S 214409 a ret finger protein-like 3 antisense i? ret finger S.27428S 214408 s at protein-like 1 antisense reticulocalbin 1, EF-hand calcium binding domain S.97887 201063 a reticulocalbin 2, EF-hand calcium binding domain S.79088 201485 S at reticulon 3 S473761 224.564 S at reticulon 4 S.429581 210968 s at reticulon 4 S.429581 211509 s at reticulon 4 S.429581 214629 x at Retinitis pigmentosa 9 (autosomal dominant) S.326805 227849 at US 2006/01992.04 A1 Sep. 7, 2006 83

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID retinitis pigmentosa GTPase regulator RPGR S.61438 207624 S at retinitis pigmentosa GTPase regulator interacting RPGRIP1 S.126035 206608 s at protein 1 retinoblastoma binding protein 4 S.16003 210371 s at retinoblastoma binding protein 6 S.188553 1552329 at retinoblastoma binding protein 6 S.188553 212781 a retinoblastoma binding protein 6 S 223802 s at retinoblastoma binding protein 7 C 7 S 201092 a retinoblastoma binding protein 8 203344 S at retinoblastoma-associated factor 600 211950 a Retinoblastoma-associated factor 600 24O108 a retinoblastoma-associated protein 140 C 4 O 209284 S at retinoblastoma-like 2 (p130) 212331 a retinoic acid induced 1 1 226143 a Retinoic acid receptor responder (tazaroteine 240936 a induced) retinoic acid receptor responder (tazaroteine R R E S 3 204070 a induced) 3 Retinoic acid receptor, alpha S.S35499 228037 a retinoid X receptor, beta S.388O34 209148 a retinol dehydrogenase 10 (all-trans) S.244940 2274.67 a retinol dehydrogenase 14 (all-trans and 9-cis) S.28888O 222203 s at EV3-like, catalytic subunit of DNA polymerase s S.232O21 238736 a a (yeast) ho family GTPase 3 D3 S.6838 212724 a ho GTPase activating protein 10 RSRHGAP10 S.368631 239567 a ho GTPase activating protein 22 RHGAP22 S.435063 1556460 a. at ho GTPase activating protein 23 RHGAP23 S.3744.46 230196. X a ho GTPase activating protein 26 RHGAP26 S.293593 1557688 at ho GTPase activating protein 28 RHGAP28 S.183114 227911 a ho GTPase activating protein 5 RHGAPS S.S2S287 242110 a ho guanine nucleotide exchange factor (GEF) 15 RHGEF15 S.443109 217348 x a ho guanine nucleotide exchange factor (GEF) 7 RHGEF7 S.SO8738 1562271 x at ho guanine nucleotide exchange factor (GEF) 7 RHGEF7 S.SO8738 202547 s a ho guanine nucleotide exchange factor (GEF) 7 RHGEF7 S.SO8738 20254.8 s a omboid, veinlet-like 7 (Drosophila) HBDL7 S.488827 222995 s a ho-related BTB domain containing 3 HOBTB3 S.445O3O 225202 at ribonuclease H1 ASEH1 S.SO2765 218497 s a ribonuclease, RNase A family, 11 (non-active) ASE11 S.112761 231603 at ribonucleasef angiogenin inhibitor S H S.S30687 1555529 at ribonucleotide reductase M1 polypeptide RM1 S.38.3396 201476 s a ribonucleotide reductase M1 polypeptide RM1 S.38.3396 201477 s a ribonucleotide reductase M2 B (TP53 inducible) RM2B S.S12592 223342 at ribonucleotide reductase M2 polypeptide RM2 S.226390 209773 s a ribophorin II PN2 S.370895 208689 s a ribosomal protein L10a L10A S.148340 229563 s a Ribosomal protein L10a L10A S.148340 2421.88 at ribosomal protein L12 ribosomal protein L12 L12 S.408054 200088 x a ribosomal protein L13 L13 S.410817 212933 x a ribosomal protein L14 L14 S.446522 213588 x a ribosomal protein L15 L15 S.381,219 221476 s a ribosomal protein L15 similar to ribosomal L15 S.381,219 217266 at protein L15 f ribosomal protein L17 S.374588 212270 x a ribosomal protein L21 ribosomal protein L21 S.381.123 200012 x a ribosomal protein L22 S.S15329 208768 x a ribosomal protein L22 S.S15329 214042 s a ribosomal protein L22 S.S15329 220960 x a ribosomal protein L22 S.S15329 221775 X a ribosomal protein L23 S.4063OO 200888 s a ribosomal protein L23a S.419463 203012 x a ribosomal protein L23a S.419463 208.825 X a ribosomal protein L23a S.419463 208834 x a ribosomal protein L23a S.419463 213084 x a ribosomal protein L26-like 1 S.546,390 218830 at ribosomal protein L27 i? ribosomal protein L27 S.5141.96 200025 s a ribosomal protein L30 ribosomal protein L30 S.400295 200062 s a ribosomal protein L31 S.469473 200963 x a ribosomal protein L34 i? ribosomal protein L34 f// S.512199 200026 at similar to ribosomal protein L34; 60S ribosomal US 2006/01992.04 A1 Sep. 7, 2006 84

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID protein L34 i? similar to ribosomal protein L34; 60S LOC342994 ribosomal protein L34 ribosomal protein L35 ribosomal protein L35 RPL35 S.182825 200002 at ribosomal protein L35a RPL3SA S.529631 213687 s a Ribosomal protein L35a RPL3SA S.529631 215208 x a ribosomal protein L35a RPL3SA S.529631 225190 x a ribosomal protein L37 ribosomal protein L37 RPL37 S.80545 200092 s a ribosomal protein L37a RPL37A S.433701 201429 s a ribosomal protein L38 RPL38 S.380953 202029 x a ribosomal protein L39 RPL39 S.300141 2O8695 s a Ribosomal protein L4 RPL4 S.432898 226190 at Ribosomal protein L4 RPL4 S.432898 226556 at ribosomal protein L4 ribosomal protein L4 RPL4 S.1863SO 20008.9 s a ribosomal protein L41 RPL41 S.381172 201492 s a ribosomal protein L5 RPL5 S.S32359 200937 S a ribosomal protein L5 RPL5 S.S32359 213080 x a ribosomal protein L6 ribosomal protein L6 RPL6 S.528668 200034 S a ribosomal protein L7 RPL7 S.421257 200717 x a ribosomal protein L7 RPL7 S.421257 212042 x a ribosomal protein L7a RPL7A S.499839 224930 x a ribosomal protein L7-like 1 similar to RPL7L1 RPL7L1 S.SSOS64 233013 x a protein LOC4O1197 ribosomal protein L9 ribosomal protein L9 RPL9 S.412370 200032 S a ribosomal protein S10 RPS10 S.406620 200817 x a ribosomal protein S10 RPS10 S.406620 211542 X a Ribosomal protein S10 RPS10 S.406620 237703 at ribosomal protein S10 / ribosomal protein S10 RPS10 S.406620 200095 x a ribosomal protein S13 fit ribosomal protein S13 RPS13 S.446588 200018 at ribosomal protein S14 RPS1.4 S.381126 208.645 s a ribosomal protein S15a i? ADP-ribosylation factor- RPS1SA S.370504 200781 s a like 6 interacting protein RL6IP ribosomal protein S16 PS16 S.397609 226131 s a ribosomal protein S20 PS2O S.8102 20094.9 x a ribosomal protein S20 PS2O S.8102 214003 x a ribosomal protein S21 PS21 S.190968 200834 S a ribosomal protein S23 PS23 S.386.384 200926 at ribosomal protein S25 ft, ribosomal protein S25 PS25 S.S12676 200091 s a ribosomal protein S26 PS26 S.355957 217753 S a ribosomal protein S27 (metallopansitimulin 1) PS27 S.546291 200741 s a ribosomal protein S27-like PS27L S.108957 218007 s a ribosomal protein S27-like PS27L S.108957 222487 s a ribosomal protein S28 PS28 S.153177 208904 S a ribosomal protein S29 PS29 S.156367 201094 at ribosomal protein S3 PS3 S.546286 208692 at ribosomal protein S3A PS3A S.356572 201257 x a ribosomal protein S3A PS3A S.356572 212391 x a ribosomal protein S3A i? ribosomal protein S3A PS3A S.356572 200099 s a ribosomal protein S4, X-linked PS4X S.446628 200933 x a ribosomal protein S4, X-linked PS4X S.446628 213347 x a ribosomal protein S6 PS6 S.408073 201254 x a ribosomal protein S6 PS6 S.408073 209134 S a Ribosomal protein S6 PS6 S.408073 238156 at ribosomal protein S6 i? ribosomal protein S6 PS6 S.408073 200081 s a ribosomal protein S6 kinase, 52 kDa, polypeptide 1 PS6KC1 S.3O352 218909 at ribosomal protein S6 kinase, 90 kDa, polypeptide 2 PS6KA2 S.147119 204906 at ribosomal protein S6 kinase, 90 kDa, polypeptide 5 PS6KAS S.S10225 204635 at ribosomal protein S7 PS7 S.534346 213941 x at ribosomal protein S8 PS8 S.S12675 200858 s at ribosomal protein, large, PO PLPO S.448226 201033 x at ribosomal protein, large, P1 PLP1 S.356SO2 200763 s at ribosome binding protein 1 homolog 180 kDa (dog) RBP1 S.472213 201205 at rififylin FFL S.1368O 1552649 a. at rififylin FFL S.1368O 228980 at ring finger and CHY Zinc finger domain containing 1 S.48297 214281 s at ring finger and KH domain containing 1 S.436495 91816 f at ring finger and KH domain containing 2 S.465144 1556874 a at ring finger and KH domain containing 2 S.465144 222567 s at ring finger and KH domain containing 3 S.104744 223627 at ring finger protein 11 RNF11 S.309641 208924 at US 2006/01992.04 A1 Sep. 7, 2006 85

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Ring finger protein 12 F12 S.1221.21 24.2121 a ring finger protein 13 F13 S.12333 201779 S at Ring finger protein 13 F13 S.12333 237264 a Ring finger protein 130 F130 S.484363 239886 a ring finger protein 133 F133 S.S49267 231373 a Ring finger protein 138 pseudogene 1 F138P1 S.SS1596 243442 X at ring finger protein 139 F139 S.492751 209510 a ring finger protein 14 F14 S.SO8993 201823 s at ring finger protein 141 F141 S.44685 219104 a ring finger protein 146 F146 S.26712O 223886 s at ring finger protein 148 F148 S.S29656 242925 a. ring finger protein 168 F168 S.S18396 1553127 a. at ring finger protein 170 F170 S.491626 1554.312 at ring finger protein 19 F19 S.292.882 223085 a. Ring finger protein 19 F19 S.292.882 230599 a ring finger protein 20 F2O S.168.095 222683 a ring finger protein 32 ring finger protein 32 F32 S.490715 220991 s a ring finger protein 34 F34 S.292804 219035 s a ring finger protein 38 F38 S.333S03 218528 s a ring finger protein 38 F38 S.333S03 222660 S a ring finger protein 7 F7 S.134623 218286 s a ring finger protein 7 ring finger protein 7 F7 S.134623 224394 at ring finger protein 7 ring finger protein 7 F7 S.134623 224395 s a ring finger protein 7 ring finger protein 7 F7 S.134623 224439 x a RING1 and YY1 binding protein BP HS.7910 201844 S a RING1 and YY1 binding protein BP HS.7910 201846 s a RING1 and YY1 binding protein BP HS.7910 237456 a ring-box BX1 S.474949 218117 a RIO kinase 3 (yeast) i? RIO kinase 3 (yeast) OK3 S.445511 202129 s a RIO kinase 3 (yeast) i? RIO kinase 3 (yeast) OK3 S.445511 2021.30 a. RNA binding motif protein 12 BM12 S.246413 212168 a RNA binding motif protein 15 BM15 S.435947 1555762 s at RNA binding motif protein 15 BM15 S.435947 219286 s a RNA binding motif protein 15B BM1SB S.476291 202689 a RNA binding motif protein 15B BM1SB S.476291 226987 a RNA binding motif protein 16 BM16 S.2276O2 203250 a RNA binding motif protein 17 BM17 S.498.548 224780 a RNA binding motif protein 25 BM2S S.531106 1557081 at RNA binding motif protein 25 BM2S S.531106 212027 a RNA binding motif protein 27 BM27 S.61441 225326 a RNA binding motif protein 4 BM4 S.S33712 200997 a RNA binding motifi protein 5 BMS S.43948O 201395 a RNA binding motifi protein 6 BM6 S.188879 1556672 a. at RNA binding motifi protein 6 BM6 S.188879 228030 a. RNA binding motifi protein 8A BM8A S.SS2581 214113 s a RNA binding motifi protein 8A BM8A S.SS2581 222443 s a RNA binding motifi protein, X-linked BMX S.380118 225310 a RNA binding motif,i single stranded interacting BMS3 S.221436 206767 a protein RNA binding motif, single stranded interacting BMS1 S.470412 215127 s a protein 1 RNA binding motif, single stranded interacting RBMS1 S.470412 225265 a protein 1 RNA binding protein S1, serine-rich domain fif RNPS1 S.355643 200060 S a RNA binding protein S1, serine-rich domain RNA binding protein with multiple splicing RBPMS S.334587 1557223 at RNA binding protein with multiple splicing RBPMS S.334587 2094.87 at RNA guanylyltransferase and 5'-phosphatase RNGTT S.127219 204207 s a RNA guanylyltransferase and 5'-phosphatase RNGTT S.127219 211387 x a RNA methyltransferase like 1 RNMTL1 S.182729 218993 at RNA processing factor 1 RPF1 S.4812O2 218462 at RNA, U17D small nucleolar RNU17D 215011 at RNA-binding region (RNP1, RRM) containing 2 RNPC2 S.2829O1 208720 s a ROD1 regulator of differentiation 1 (S. pombe) ROD1 S.269988 207223 s a ropporin, rhophilin associated protein 1 ROPN1 S.4583O4 224191 x a ropporin, rhophilin associated protein 1 ROPN1 S.4583O4 231535 X a ropporin, rhophilin associated protein 1 ROPN1 S.4583O4 233203 at ropporin, rhophilin associated protein 1B ROPN1B S.S282O3 220425 x a rotatin RTTN S.31931 1557388 at rotavirus X protein associated with NSP3 ROXaN S.474970 206169 x a round spermatid basic protein 1 RSBN1 S.486.285 222789 at US 2006/01992.04 A1 Sep. 7, 2006 86

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID RP42 homolog P42 S.104613 218583 s a RP42 homolog P42 S.104613 222679 s a RP42 homolog P42 S.104613 24O150 a RP42 homolog P42 S.104613 242428 a RPA interacting protein S.SSOS38 1556088 at RPA interacting protein P S.SSOS38 2281.83 s a RPE-spondin PESP S.439040 235209 a RPE-spondin PESP S.439040 23521.0 s a RRN3 RNA polymerase I transcription factor RN3 S.46OO78 216902 s a homolog (yeast) RUN and FYVE domain containing 2 UFY2 S.S49177 233.191 a RUN and TBC1 domain containing 1 UTBC1 S.513861 217538 a RUN and TBC1 domain containing 3 UTBC3 S.474.914 214779 s a runt-related transcription factor 3 3 S.170019 204197 s 8. RWD domain containing 1 S.S321.64 219598 s a ryanodine receptor 3 S.549061 206306 a RYK receptor-like tyrosine kinase YUNXK S.245869 214172 X a S100 calcium binding protein A10 (annexin II OOA10 S.143873 200872 a. igand, calpactin I, light polypeptide (p11)) S100 calcium binding protein A10 (annexin II S OOA10 S.143873 238909 a igand, calpactin I, light polypeptide (p11)) S100 calcium binding protein A8 (calgranulin A) S100A8 S.416O73 202917 s at S-adenosylhomocysteine hydrolase AHCY S.388OO)4 200903 s at S-adenosylhomocysteine hydrolase-like 1 AHCYL1 S.485365 200850 s at SAM and SH3 domain containing 1 SASH1 S.1931.33 24.0113 a SAR1a gene homolog 1 (S. cerevisiae) SARA1 S.4.99960 201542 a. sarcoglycan, beta (43 kDa dystrophin-associated SGCB S.438.953 205120 s at glycoprotein) sarcolipin SLN S.3346.29 205374 a Sarcoma antigen NY-SAR-27 FLJ10330 S.342307 230270 a sarcoma antigen NY-SAR-91 FLJ11730 S.17118 21816S a Scavenger receptor class B, member 2 SCARB2 S.349656 201647 s at Scavenger receptor class B, member 2 SCARB2 S.349656 215754 a Scavenger receptor class B, member 2 SCARB2 S.349656 224983 a Scm-like with four mbt domains 1 SFMBT1 S.343679 213370 s at Scotin SCOTIN S.414579 222986 s at scrapie responsive protein 1 SCRG S.7122 205475 a. SCRL protein SCRL S.414175 240559 a SCY1-like 2 (S. cerevisiae) SCYL2 S.506481 224960 a SCY1-like 3 (S. cerevisiae) PACE S.435560 231111 at SDA1 domain containing 1 S.27O107 218607 s at SDA1 domain containing 1 S.27O107 2284.08 s at Sec1 family domain containing 1 S.3691.68 241775 a Sec1 family domain containing 2 S.302287 226923 a SEC10-like 1 (S. cerevisiae) S.365863 225.084 a EC11-like 1 (S. cerevisiae) S.9534 201290 a EC14 and spectrin domains 1 S.370668 226763 a EC14-like 1 (S. cerevisiae) S.464184 20208.2 s at EC14-like 1 (S. cerevisiae) S.464184 202083 s at EC15-like 2 (S. cerevisiae) s : S.3O3454 1569200 at EC15-like 2 (S. cerevisiae) 5 2 S.3O3454 1569202 X at EC22 vesicle trafficking protein-like 1 (S. cerevisiae) S.534212 214257 s at EC22 vesicle trafficking protein-like 2 (S. cerevisiae) E : : : S.477361 218703 at EC22 vesicle trafficking protein-like 3 (S. cerevisiae) EC22L3 S.445892 225460 at ec23 homolog B (S. cerevisiae) EC23B S.369373 210293 s at EC23 interacting protein EC23IP S.435OO)4 209175 at EC24 related gene family, member B (S. cerevisiae) EC24B S.292.472 1569713 at EC24 related gene family, member C (S. cerevisiae) EC24C S.81964 202361 at EC31-like 1 (S. cerevisiae) EC31L1 S.370O24 210616 s at EC31-like 1 (S. cerevisiae) EC31L1 S.370O24 215009 s at EC3-like 1 (S. cerevisiae) EC3L1 S.269665 222127 s at ecó1 alpha 2 subunit (S. cerevisiae) EC61A2 S.11295S 2287.47 at ecó1 alpha 2 subunit (S. cerevisiae) EC61A2 S.11295S 230215 at eco1 beta subunit EC61B S.191887 2031.33 at EC63-like (S. cerevisiae) EC63 S.S29957 201916 s at EC8-like 1 (S. cerevisiae) EC8L1 S.321,273 224926 at EC8-like 1 (S. cerevisiae) EC8L1 S.321,273 239264 at ECIS binding protein 2 ECISBP2 S.598.04 218265 at ECIS binding protein 2 SECISBP2 S.598.04 224250 s at Secretory carrier membrane protein 1 SCAMP1 S.482S87 1552978 a. at Secretory carrier membrane protein 1 SCAMP1 S.482S87 212416 at US 2006/01992.04 A1 Sep. 7, 2006 87

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID Selenocysteine lyase SCLY S.512606 221575 at Selenocysteine lyase SCLY S.512606 59705 at Selenophosphate synthetase 1 SEPHS1 S.124O27 208939 at Selenophosphate synthetase 2 SEPHS2 S.118725 200961 at selenoprotein K SELK S.58471 223.070 at selenoprotein O SELO S.36S4OS 233168 s at selenoprotein W. 1 SEPW1 S.S291.32 1555851 S. at selenoprotein W. 1 SEPW1 S.S291.32 201194 at Sema domain, immunoglobulin domain (Ig), short SEMA3C S.269109 20378.8 s at basic domain, Secreted, (Semaphorin) 3C Sema domain, transmembrane domain (TM), and SEMA6A S.156967 215479 at cytoplasmic domain, (semaphorin) 6A septin 10 10-Sep S.4696.15 214720 x at Septin 2 2-Sep s.335057 200778 s at septin 2 i? septin 2 2-Sep s.335057 200015 s at septin 7 7-Sep S.191346 213151 s at serine (or cysteine) proteinase inhibitor, clade B SERPINB11 S.3SO958 1552463 at (ovalbumin), member 11 serine (or cysteine) proteinase inhibitor, clade B S E RPINB8 S.368.077 1554616 at (ovalbumin), member 8 serine (or cysteine) proteinase inhibitor, clade E S E RPINE2 S.38449 212190 at (nexin, plasminogen activator inhibitor type 1), member 2 Serine (or cysteine) proteinase inhibitor, clade E S E RPINE2 S.38449 23.6599 at (nexin, plasminogen activator inhibitor type 1), member 2 Serine hydroxymethyltransferase 1 (soluble) SHMT1 S.S13987 227305 S at serine palmitoyltransferase, long chain base SPTLC1 S. 90458 1554053 at subunit 1 serine PI Kazal type 5-like 3 S C S.483771 233340 at serine protease inhibitor-like, with Kunitz and WAP S C S.121084 206318 at domains 1 (eppin) serine racemase S.461954 219205 at serine threonine kinase 39 (STE20/SPS1 homolog, S.276.271 202786 at yeast) serinefarginine repetitive matrix 1 RM1 S.18.192 201224 S at serinefarginine repetitive matrix 1 RM1 S.18.192 201225 s at serinefarginine repetitive matrix 2 RM2 S.433343 207435 S. at serinefarginine repetitive matrix 2 RM2 S.433343 208.610 s at serine/threonine kinase 17a (apoptosis-inducing) STK17A S.268887 202693 s at serine/threonine kinase 19 STK19 S.4851 O2 36O19 at serine/threonine kinase 24 (STE20 homolog, STK24 S.SO8514 208855 S at yeast) Serine/threonine kinase 25 (STE20 homolog, STK2S S.S16807 242932 at yeast) Serine/threonine kinase 3 (STE20 homolog, yeast) STK3 S.492.333 233779 X at serine/threonine kinase 33 STK33 S.SO1833 228O86 at serine/threonine kinase 35 STK35 S.1OOOST 225648 at serine/threonine kinase 35 STK35 S.1OOOST 225649 s at serine/threonine kinase 38 like STK38L S.184523 212572 at serine/threonine kinase 4 STK4 S.472838 1569791 at serine/threonine kinase 4 STK4 S.472838 223746 at serine/threonine kinase 4 STK4 S.472838 236259 at serine/threonine kinase 4 STK4 S.472838 243981 at serine/threonine kinase receptor associated STRAP S.SO4895 200870 at protein Serologically defined breast cancer antigen 84 SDBCAG84 S.472558 216032 S at Serologically defined colon cancer antigen 1 SDCCAG1 S.388584 1569594 a at Serologically defined colon cancer antigen 10 SDCCAG10 S.371372 1555.495 a. at Serologically defined colon cancer antigen 8 SDCCAG8 S.549104 243772 at SERTA domain containing 1 SERTAD1 S.269898 223394 at SERTA domain containing 2 SERTAD2 S.77293 202656 S at SERTA domain containing 3 SERTAD3 S.515412 219382 at serum amyloid A4, constitutive SAA4 S.S12677 207096 at Sestrin 1 SESN1 S.S9554 1556287 a. at sestrin 3 SESN3 S.12O633 235683 at SET binding factor 2 SBF2 S.438794 233914 S at SET domain, bifurcated 2 SETDB2 S.446217 235338 s at SET translocation (myeloid leukemia-associated) SET S.436687 200630 x at SET translocation (myeloid leukemia-associated) SET S.436687 210231 x at Seven in absentia homolog 1 (Drosophila) SIAH1 S.295923 202981 X at US 2006/01992.04 A1 Sep. 7, 2006 88

TABLE 1-continued

Gene Title and Probe Set ID

Gene Gene Title Symbol UniGene ID Probe Set ID sex comb on midleg-like 1 (Drosophila) SCML.1 S.1096SS 222747 s at SFRS protein kinase 1 SRPK1 S.443861 202199 s at SFRS protein kinase 1 SRPK1 S.443861 202200 s at SFRS protein kinase 2 SRPK2 S.2851.97 1558254 S at SFRS protein kinase 2 SRPK2 S.2851.97 203181 X at SFRS protein kinase 2 SRPK2 S.2851.97 203182 s at SFRS protein kinase 2 SRPK2 S.2851.97 214931 s at SFRS protein kinase 2 SRPK2 S.2851.97 230091 a SFRS protein kinase 2 SRPK2 S.2851.97 239811 a SGT1, Suppressor of G2 allele of SKP1 (S. cerevisiae) SUGT1 S.281902 223329 x at SGT1, Suppressor of G2 allele of SKP1 (S. cerevisiae) SUGT1 S.281902 224309 s at SH2 domain containing 4B SH2D4B S.147643 1563849 at SH3 and multiple ankyrin repeat domains 2 SHANK2 S.268,726 213307 a SH3 multiple domains 1 SH3MD1 S.1593.68 224817 a SH3 multiple domains 2 SH3MD2 S.3O1804 225589 a SH3-domain GRB2-like 3 SH3GL3 S.27OOSS 205636 a SH3-domain GRB2-like 3 SH3GL3 S.27OOSS 205637 S at SH3-domain GRB2-like endophilin B1 SH3GLB1 S.136309 209090 s. at SH3-domain kinase binding protein 1 SH3KBP1 S.444770 1553.588 at SH3-domain kinase binding protein 1 SH3KBP1 S.444770 shugoshin-like 1 (S. pombe) SGOL1 S.105153 1553690 at shugoshin-like 2 (S. pombe) SGOL2 S.44269 235425 a. sialic acid binding Ig-like lectin 6 SIGLEC6 S.3972SS 210796 X at sialoadhesin SN S.31869 44673 at sialophorin (gpL115, leukosialin, CD43) SPN S.461934 1568964 X at SID1 transmembrane family, member 1 SIDT1 S.272416 219734 a SID1 transmembrane family, member 2 SIDT2 S.410977 56256 at sidekick homolog 1 (chicken) SDK1 S.155959 229912 a sideroflexin 4 SFXN4 S.397062 225143 a signal peptidase complex subunit 1 homolog (S. cerevisiae) SPCS1 S.11125 217927 a signal peptidase complex subunit 2 homolog (S. cerevisiae) SPCS2 S.2827OO 201240 S at signal peptidase complex subunit 3 homolog (S. cerevisiae) SPCS3 S.42194 218817 a signal peptide peptidase-like 2A SPPL2A 226353 a signal recognition particle 14 kDa (homologous Alu SRP14 200007 a RNA binding protein) i? signal recognition particle 14 kDa (homologous Alu RNA binding protein) signal recognition particle 19 kDa SRP19 S.483O90 205335 s at signal recognition particle 54 kDa SRPS4 S.167535 20360S a signal recognition particle 68 kDa SRP68 S.514495 224607 S at signal recognition particle 72 kDa SRP72 S.23782S 208801 a Signal recognition particle 72 kDa SRP72 S.23782S 235833 a signal recognition particle 9 kDa SRP9 S.S11425 201273 s at signal recognition particle receptor, B. Subunit SRPRB S.1215.2 218140 x at Signal recognition particle receptor, B Subunit SRPRB S.1215.2 227737 a signal sequence receptor, alpha (translocon- SSR S.114033 200891 s at associated protein alpha) Signal sequence receptor, alpha (translocon- SSR S.114033 225435 a. associated protein alpha) signal sequence receptor, gamma (translocon- SSR3 S.51.8346 222411 s at associated protein gamma) signal transducer and activator of transcription 2, STAT2 S.S30595 205170 a 113 kDa signal transducer and activator of transcription 3 STAT3 S.463059 208991 a (acute-phase response factor) signal transducer and activator of transcription 3 STAT3 S.463059 243213 a (acute-phase response factor) signal transducer and activator of transcription 4 STAT4 S.80642 206118 a signal-induced proliferation-associated 1 like 2 SIPA1L2 S.268774 233587 S at signal-transducing adaptor protein-2 STAP2 S.194385 221610 S at Similar to 40S ribosomal protein S3 S.461.453 1556595 at Similar to 60S ribosomal protein L23a S.440962 229420 a similar to 60S ribosomal protein L7a (Surfeit locus LOC441422 S.99081 236453 a protein 3) (PLA-X polypeptide) similar to Ab2-183 LOC158830 S.443936 231377 a Similar to amyloid beta (A4) precursor protein S.1781.86 243971 x at binding, family B, member 1 interacting protein; proline-rich protein 73; Rap1-interacting adaptor molecule Similar to ankyrin repeat domain 20A S.SS2629 242766 at Similar to ankyrin-repeat protein Nrarp MGC61598 S.5.35075 226499 at