Research publications of the Cluster of Excellence Macromolecular Complexes
(full list of original peer-reviewed papers 2007-2019, last update: 14 January 2020)
2019
Abhari BA, McCarthy N, Agostinis P, Fulda S (2019) NF-kappaB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis. Apoptosis: published online 24 January 2019. http://dx.doi.org/10.1007/s10495-018-1507-2
Abhari BA, McCarthy N, Le Berre M, Kilcoyne M, Joshi L, Agostinis P, Fulda S (2019) Smac mimetic suppresses tunicamycin- induced apoptosis via resolution of ER stress. Cell Death Dis 10: 155. http://dx.doi.org/10.1038/s41419-019-1381-z
Alriquet M, Martinez-Limon A, Hanspach G, Hengesbach M, Tartaglia GG, Calloni G, Vabulas RM (2019) Assembly of proteins by free RNA during the early phase of proteostasis stress. J Proteome Res: published online 5 June 2019. http://dx.doi.org/10.1021/acs.jproteome.9b00143
Alvarez-Castelao B, Schanzenbächer CT, Langer JD, Schuman EM (2019) Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo. Nat Protoc 14: 556–575. http://dx.doi.org/10.1038/s41596-018-0106-6
Asido M, Eberhardt P, Kriebel CN, Braun M, Glaubitz C, Wachtveitl J (2019) Time-resolved IR spectroscopy reveals mechanistic details of ion transport in the sodium pump Krokinobacter eikastus rhodopsin 2. Phys Chem Chem Phys: published online 1 February 2019. http://dx.doi.org/10.1039/c8cp07418f
Asquith CRM, Berger BT, Wan J, Bennett JM, Capuzzi SJ, Crona DJ, Drewry DH, East MP, Elkins JM, Fedorov O, Godoi PH, Hunter DM, Knapp S, Müller S, Torrice CD, Wells CI, Earp HS, Willson TM, Zuercher WJ (2019) SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK). J Med Chem: published online 15 February 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01213
Azimi Hashemi N, Bergs ACF, Schüler C, Scheiwe AR, Steuer Costa W, Bach M, Liewald JF, Gottschalk A (2019) Rhodopsin- based voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans. Proc Natl Acad Sci USA 116: 17051- 17060. http://dx.doi.org/10.1073/pnas.1902443116
Baldering TN, Bullerjahn JT, Hummer G, Heilemann M, Malkusch S (2019) Molecule counts in complex oligomers with single- molecule localization microscopy. J Phys D - Appl Phys 52: 474002. http://dx.doi.org/10.1088/1361-6463/ab3b65
Baldering TN, Dietz MS, Gatterdam K, Karathanasis C, Wieneke R, Tampé R, Heilemann M (2019) Synthetic and genetic dimers as quantification ruler for single-molecule counting with PALM. Mol Biol Cell: mbcE18100661. http://dx.doi.org/10.1091/mbc.E18-10-0661
Bausewein T, Nussberger S, Kühlbrandt W (2019) Cryo-EM structure of Neurospora crassa respiratory complex IV. IUCrJ 6: 773-780. http://dx.doi.org/10.1107/s2052252519007486
Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I (2019) AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting. Acta Physiol (Oxf): e13325. http://dx.doi.org/10.1111/apha.13325
Berz J, Simm S, Schuster S, Scharf KD, Schleiff E, Ebersberger I (2019) HEATSTER: A Database and Web Server for Identification and Classification of Heat Stress Transcription Factors in Plants. Bioinform Biol Insights 13: published online 7 January 2019. http://dx.doi.org/10.1177/1177932218821365
Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I, Hummer G (2019) Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy. Nat Commun 10: 2370. http://dx.doi.org/10.1038/s41467-019-10345-3
1 Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I (2019) Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin-catalysed glutamylation. Nature 572: 382–386. http://dx.doi.org/10.1038/s41586-019-1440-8
Blum TB, Hahn A, Meier T, Davies KM, Kühlbrandt W (2019) Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows. Proc Natl Acad Sci USA 116: 4250-4255. http://dx.doi.org/10.1073/pnas.1816556116
Bock C, Zollmann T, Lindt KA, Tampé R, Abele R (2019) Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy. Sci Rep 9: 11884. http://dx.doi.org/10.1038/s41598-019-48343-6
Bodensohn US, Simm S, Fischer K, Jaschke M, Gross LE, Kramer K, Ehmann C, Rensing SA, Ladig R, Schleiff E (2019) The intracellular distribution of the components of the GET system in vascular plants. Biochim Biophys Acta Mol Cell Res: published online 21 June 2019. http://dx.doi.org/10.1016/j.bbamcr.2019.06.012
Boger C, Hafner AS, Schlichtharle T, Strauss MT, Malkusch S, Endesfelder U, Jungmann R, Schuman EM, Heilemann M (2019) Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography. Neurophotonics 6: 035008. http://dx.doi.org/10.1117/1.NPh.6.3.035008
Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M (2019) Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization. Microbiology: published online 24 July 2019. http://dx.doi.org/10.1099/mic.0.000835
Braner M, Koller N, Knauer J, Herbring V, Hank S, Wieneke R, Tampé R (2019) Optical control of the antigen translocation by synthetic photo-conditional viral inhibitors. Chem Sci 10: 2001-2005. http://dx.doi.org/10.1039/c8sc04863k
Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, Yutin N, Rosselli R, Baeken C, Borshchevskiy V, Bourenkov G, Popov A, Balandin T, Buldt G, Manstein DJ, Rodriguez-Valera F, Fahlke C, Bamberg E, Koonin E, Gordeliy V (2019) Unique structure and function of viral rhodopsins. Nat Commun 10: 4939. http://dx.doi.org/10.1038/s41467-019-12718-0
Brouwer EM, Ngo G, Yadav S, Ladig R, Schleiff E (2019) Tic22 from Anabaena sp. PCC 7120 with holdase function involved in outer membrane protein biogenesis shuttles between plasma membrane and Omp85. Mol Microbiol: published online 11 February 2019. http://dx.doi.org/10.1111/mmi.14222
Bueno C, Calero-Nieto FJ, Wang X, Valdes-Mas R, Gutierrez-Aguera F, Roca-Ho H, Ayllon V, Real PJ, Arambile D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P (2019) Enhanced hemato- endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions. Haematologica: published online 27 January 2019. http://dx.doi.org/10.3324/haematol.2018.202044
Cetiner EC, Jonker HRA, Helmling C, Gophane DB, Grunewald C, Sigurdsson ST, Schwalbe H (2019) Paramagnetic-iterative relaxation matrix approach: extracting PRE-restraints from NOESY spectra for 3D structure elucidation of biomolecules. J Biomol NMR: http://dx.doi.org/10.1007/s10858-019-00282-0
Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S (2019) Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem J 476: 875-887. http://dx.doi.org/10.1042/bcj20190038
Chang YN, Jaumann EA, Reichel K, Hartmann J, Oliver D, Hummer G, Joseph B, Geertsma ER (2019) Structural basis for functional interactions in dimers of SLC26 transporters. Nat Commun 10: 2032. http://dx.doi.org/10.1038/s41467-019-10001- w
Cottilli P, Belda-Palazon B, Adkar-Purushothama CR, Perreault JP, Schleiff E, Rodrigo I, Ferrando A, Lison P (2019) Citrus exocortis viroid causes ribosomal stress in tomato plants. Nucleic Acids Res: published online 8 August 2019. http://dx.doi.org/10.1093/nar/gkz679
2 Covino R, Woodside MT, Hummer G, Szabo A, Cossio P (2019) Molecular free energy profiles from force spectroscopy experiments by inversion of observed committors. J Chem Phys 151: 154115. http://dx.doi.org/10.1063/1.5118362
Dachert J, Ehrenfeld V, Habermann K, Dolgikh N, Fulda S (2019) Targeting ferroptosis in rhabdomyosarcoma cells. Int J Cancer: published online 7 June 2019. http://dx.doi.org/10.1002/ijc.32496
Di Liddo A, de Oliveira Freitas Machado C, Fischer S, Ebersberger S, Heumuller AW, Weigand JE, Muller-McNicoll M, Zarnack K (2019) A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress. J Mol Cell Biol: published online 27 September 2019. http://dx.doi.org/10.1093/jmcb/mjz094
Diederichs T, Pugh G, Dorey A, Xing Y, Burns JR, Hung Nguyen Q, Tornow M, Tampé R, Howorka S (2019) Synthetic protein- conductive membrane nanopores built with DNA. Nat Commun 10: 5018. http://dx.doi.org/10.1038/s41467-019-12639-y
Dietz MS, Wehrheim SS, Harwardt MIE, Niemann HH, Heilemann M (2019) Competitive binding study revealing the influence of fluorophore labels on biomolecular interactions. Nano Lett: published online 17 October 2019. http://dx.doi.org/10.1021/acs.nanolett.9b03736
D'Imprima E, Floris D, Joppe M, Sanchez R, Grininger M, Kühlbrandt W (2019) Protein denaturation at the air-water interface and how to prevent it. eLlife 8: published online 1 April 2019. http://dx.doi.org/10.7554/eLife.42747
DiPrima M, Wang D, TrOster A, Maric D, Terrades-Garcia N, Ha T, Kwak H, Sanchez-Martin D, Kudlinzki D, Schwalbe H, Tosato G (2019) Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma. Mol Oncol: published online 23 September 2019. http://dx.doi.org/10.1002/1878-0261.12576
Dreis C, Ottenlinger FM, Putyrski M, Ernst A, Huhn M, Schmidt KG, Pfeilschifter JM, Radeke HH (2019) Tissue cytokine IL-33 modulates the cytotoxic CD8 T lymphocyte activity during nutrient deprivation by regulation of lineage-specific differentiation programs. Front Immunol 10: 1698. http://dx.doi.org/10.3389/fimmu.2019.01698
Duchatelet S, Russo C, Osterburg C, Mallet S, Bole-Feysot C, Nitschke P, Richard MA, Dötsch V, Missero C, Nassif A, Hovnanian A (2019) A TP63 mutation causes prominent alopecia with mild ectodermal dysplasia. J Invest Dermatol: http://dx.doi.org/10.1016/j.jid.2019.06.154
Dutta P, Odedra D, Pohl C (2019) Planar asymmetries in the C. elegans embryo emerge by differential retention of aPARs at cell-cell contacts. Front Cell Dev Biol 7: 209. http://dx.doi.org/10.3389/fcell.2019.00209
Ehrenfeld V, Fulda S (2019) Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells. Biol Chem: published online 29 July 2019. http://dx.doi.org/10.1515/hsz-2019-0160
Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshugel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR (2019) Activation of caspase-6 is promoted by a mutant Huntingtin fragment and blocked by an allosteric inhibitor compound. Cell Chem Biol: published online 25 July 2019. http://dx.doi.org/10.1016/j.chembiol.2019.07.001
El-Shershaby A, Ullrich S, Simm S, Scharf KD, Schleiff E, Fragkostefanakis S (2019) Functional diversification of tomato HsfA1 factors is based on DNA binding domain properties. Gene: 143985. http://dx.doi.org/10.1016/j.gene.2019.143985
Elwakeel E, Brüggemann M, Fink AF, Schulz MH, Schmid T, Savai R, Brüne B, Zarnack K, Weigert A (2019) Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development. Int J Mol Sci 20: http://dx.doi.org/10.3390/ijms20184438
Faelber K, Dietrich L, Noel JK, Wollweber F, Pfitzner AK, Mühleip A, Sanchez R, Kudryashev M, Chiaruttini N, Lilie H, Schlegel J, Rosenbaum E, Hessenberger M, Matthaeus C, Kunz S, von der Malsburg A, Noe F, Roux A, van der Laan M, Kühlbrandt W, Daumke O (2019) Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature 571: 429–433. http://dx.doi.org/10.1038/s41586-019-1372-3
3 Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I (2019) Myeloid-specific deletion of the AMPKalpha2 subunit alters monocyte protein expression and atherogenesis. Int J Mol Sci 20: published online 19 June 2019. http://dx.doi.org/10.3390/ijms20123005
Fonkeu Y, Kraynyukova N, Hafner A-S, Kochen L, Sartori F, Schuman EM, Tchumatchenko T (2019) How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics. Neuron: published online 23 July 2019. http://dx.doi.org/10.1016/j.neuron.2019.06.022
Foong WE, Tam HK, Crames JJ, Averhoff B, Pos KM (2019) The chloramphenicol/H+ antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity. J Antimicrob Chemother: published online 19 February 2019. http://dx.doi.org/10.1093/jac/dkz024
Fottner M, Brunner AD, Bittl V, Horn-Ghetko D, Jussupow A, Kaila VRI, Bremm A, Lang K (2019) Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase. Nat Chem Biol 15: 276-284. http://dx.doi.org/10.1038/s41589-019- 0227-4
Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk SJL, Fulda S (2019) Cell cycle arrest in mitosis promotes interferon-induced necroptosis. Cell Death Differ: published online 11 February 2019. http://dx.doi.org/10.1038/s41418-019-0298-5
Geiger C, Korn SM, Häsler M, Peetz O, Martin J, Kötter P, Morgner N, Entian KD (2019) Functional analysis of LanI mediated lantibiotic immunity in Bacillus subtilis. Appl Environ Microbiol: published online 5 April 2019. http://dx.doi.org/10.1128/aem.00534-19
Gouridis G, Hetzert B, Kiosze-Becker K, de Boer M, Heinemann H, Nürenberg-Goloub E, Cordes T, Tampé R (2019) ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium. Cell Reports 28: 723-734.e6. http://dx.doi.org/https://doi.org/10.1016/j.celrep.2019.06.052
Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R (2019) Lysosomal targeting of the ABC transporter TAPL is determined by membrane localized charged residues. J Biol Chem: published online 15 March 2019. http://dx.doi.org/10.1074/jbc.RA118.007071
Grammbitter GLC, Schmalhofer M, Karimi K, Shi Y-M, Schöner TA, Tobias NJ, Morgner N, Groll M, Bode HB (2019) An uncommon type II PKS catalyzes biosynthesis of aryl polyene pigments. J Am Chem Soc: published online 25 March 2019. http://dx.doi.org/10.1021/jacs.8b10776
Grebenovsky N, Luma L, Müller P, Heckel A (2019) Introducing LNAzo: more rigidity for improved photocontrol of oligonucleotide hybridization. Chemistry: published online 6 August 2019. http://dx.doi.org/10.1002/chem.201903240
Gustmann H, Segler AJ, Gophane DB, Reuss AJ, Grünewald C, Braun M, Weigand JE, Sigurdsson ST, Wachtveitl J (2019) Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer. Nucleic Acids Res 47: 15-28. http://dx.doi.org/10.1093/nar/gky1110
Hafner A-S, Donlin-Asp PG, Leitch B, Herzog E, Schuman EM (2019) Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments. Science 364: eaau3644. http://dx.doi.org/10.1126/science.aau3644
Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brune B, Weigert A (2019) IL-38 ameliorates skin inflammation and limits IL-17 production from gammadelta T Cells. Cell Rep 27: 835-846.e5. http://dx.doi.org/10.1016/j.celrep.2019.03.082
Hannig J, Schäfer H, Ackermann J, Hebel M, Schäfer T, Döring C, Hartmann S, Hansmann M-L, Koch I (2019) Bioinformatics analysis of whole slide images reveals significant neighborhood preferences of tumor cells in Hodgkin lymphoma. PLoS Computational Biology: in press. http://dx.doi.org/10/ not yet available
4 Harde E, Nicholson L, Furones Cuadrado B, Bissen D, Wigge S, Urban S, Segarra M, Ruiz de Almodovar C, Acker-Palmer A (2019) EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. eLife 8: e49819. http://dx.doi.org/10.7554/eLife.49819
He B, Buescher M, Farnworth MS, Strobl F, Stelzer EH, Koniszewski ND, Muehlen D, Bucher G (2019) An ancestral apical brain region contributes to the central complex under the control of foxQ2 in the beetle Tribolium. eLife 8: published online 18 October 2019. http://dx.doi.org/10.7554/eLife.49065
Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S (2019) Molecular recognition of M1-linked ubiquitin chains by native and phosphorylated UBAN domains. J Mol Biol: published online 24 June 2019. http://dx.doi.org/10.1016/j.jmb.2019.06.012
Hetzke T, Bowen AM, Vogel M, Gauger M, Suess B, Prisner TF (2019) Binding of tetracycline to its aptamer determined by 2D- correlated Mn(2+) hyperfine spectroscopy. J Magn Reson 303: 105-114. http://dx.doi.org/10.1016/j.jmr.2019.04.011
Heumüller M, Glock C, Rangaraju V, Biever A, Schuman EM (2019) A genetically encodable cell-type-specific protein synthesis inhibitor. Nat Methods: published online 15 July 2019. http://dx.doi.org/10.1038/s41592-019-0468-x
Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant JY, Zarnack K, König J, Beli P (2019) The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Genome Biol 20: 216. http://dx.doi.org/10.1186/s13059-019-1814-0
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, Moeller A (2019) Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature 571: 580–583. http://dx.doi.org/10.1038/s41586-019-1391-0
Holdgaard SG, Cianfanelli V, Pupo E, Lambrughi M, Lubas M, Nielsen JC, Eibes S, Maiani E, Harder LM, Wesch N, Foged MM, Maeda K, Nazio F, de la Ballina LR, Dötsch V, Brech A, Frankel LB, Jaattela M, Locatelli F, Barisic M, Andersen JS, Bekker-Jensen S, Lund AH, Rogov VV, Papaleo E, Lanzetti L, De Zio D, Cecconi F (2019) Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites. Nat Commun 10: 4176. http://dx.doi.org/10.1038/s41467-019-12094- 9
Hotte K, Koch M, Hof L, Tuppi M, Moreth T, Verstegen MMA, van der Laan LJW, Stelzer EHK, Pampaloni F (2019) Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens. Sci Rep 9: 17292. http://dx.doi.org/10.1038/s41598-019-53380-2
Hu Y, Mesihovic A, Jimenez-Gomez JM, Roth S, Gebhardt P, Bublak D, Bovy A, Scharf KD, Schleiff E, Fragkostefanakis S (2019) Natural variation in HsfA2 pre-mRNA splicing is associated with changes in thermotolerance during tomato domestication. New Phytol: published online 26 September 2019. http://dx.doi.org/10.1111/nph.16221
Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV (2019) An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5. Autophagy: published online 16 April 2019. http://dx.doi.org/10.1080/15548627.2019.1606637
Joseph B, Jaumann EA, Sikora A, Barth K, Prisner TF, Cafiso DS (2019) In situ observation of conformational dynamics and protein ligand-substrate interactions in outer-membrane proteins with DEER/PELDOR spectroscopy. Nat Protoc: http://dx.doi.org/10.1038/s41596-019-0182-2
Juretschke T, Beli P, Dikic I (2019) Quantitative phosphoproteomics of selective autophagy receptors. Methods Mol Biol 1880: 691-701. http://dx.doi.org/10.1007/978-1-4939-8873-0_46
5 Key J, Kohli A, Barcena C, Lopez-Otin C, Heidler J, Wittig I, Auburger G (2019) Global proteome of LonP1(+/-) mouse embryonal fibroblasts reveals impact on respiratory chain, but no interdependence between Eral1 and mitoribosomes. Int J Mol Sci 20: http://dx.doi.org/10.3390/ijms20184523
Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N, Auburger G (2019) Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol Dis: published online 11 February 2019. http://dx.doi.org/10.1016/j.nbd.2019.02.008
Khandelwal KD, van den Boogaard MH, Mehrem SL, Gebel J, Fagerberg C, van Beusekom E, van Binsbergen E, Topaloglu O, Steehouwer M, Gilissen C, Ishorst N, van Rooij I, Roeleveld N, Christensen K, Schoenaers J, Berge S, Murray JC, Hens G, Devriendt K, Ludwig KU, Mangold E, Hoischen A, Zhou H, Dötsch V, Carels CEL, van Bokhoven H (2019) Deletions and loss-of- function variants in TP63 associated with orofacial clefting. Eur J Hum Genet: published online 8 March 2019. http://dx.doi.org/10.1038/s41431-019-0370-0
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M (2019) Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains. ACS Chem Biol: published online 25 January 2019. http://dx.doi.org/10.1021/acschembio.8b01060
Klinger A, Gosch V, Bodensohn U, Ladig R, Schleiff E (2019) The signal distinguishing between targeting of outer membrane beta-barrel protein to plastids and mitochondria in plants. Biochim Biophys Acta Mol Cell Res 1866: 663-672. http://dx.doi.org/10.1016/j.bbamcr.2019.01.004
Köfinger J, Stelzl LS, Reuter K, Allande C, Reichel K, Hummer G (2019) Efficient Ensemble Refinement by Reweighting. J Chem Theory Comput: published online 2 April 2019. http://dx.doi.org/10.1021/acs.jctc.8b01231
Königs V, Machado CdOF, Arnold BL, Blümel N, Solovyeva A, Löbbert S, Schafranek M, Mozos IRDL, Wittig I, McNicoll F, Schulz MH, Müller-McNicoll M (2019) SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly. Nat Struct Mol Biol: in press. http://dx.doi.org/10. not yet available
Kovacevic J, Palm D, Jooss D, Bublak D, Simm S, Schleiff E (2019) Co-orthologues of ribosome biogenesis factors in A. thaliana are differentially regulated by transcription factors. Plant Cell Rep: published online 13 May 2019. http://dx.doi.org/10.1007/s00299-019-02416-y
Kovalev K, Polovinkin V, Gushchin I, Alekseev A, Shevchenko V, Borshchevskiy V, Astashkin R, Balandin T, Bratanov D, Vaganova S, Popov A, Chupin V, Buldt G, Bamberg E, Gordeliy V (2019) Structure and mechanisms of sodium-pumping KR2 rhodopsin. Sci Adv 5: eaav2671. http://dx.doi.org/10.1126/sciadv.aav2671
Krchňáková Z, Thakur PK, Krausová M, Bieberstein N, Haberman N, Müller-McNicoll M, Staněk D (2019) Splicing of long non- coding RNAs primarily depends on polypyrimidine tract and 5′ splice-site sequences due to weak interactions with SR proteins. Nucleic Acids Res 47: 911-928. http://dx.doi.org/10.1093/nar/gky1147
Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ (2019) ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Nat Commun 10: 486. http://dx.doi.org/10.1038/s41467-019-08420-w
Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H (2019) Solution structure and dynamics of the small protein HVO_2922 from Haloferax volcanii. Chembiochem: published online 4 June 2019. http://dx.doi.org/10.1002/cbic.201900085
Langebeck-Jensen K, Shahar OD, Schuman EM, Langer JD, Ryu S (2019) Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge. Proteomics: e1900028. http://dx.doi.org/10.1002/pmic.201900028
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Watts E, Heidenreich D, Tucker E, Raab M, Strebhardt K, Chesler L, Knapp S, Bellenie B, Hoelder S (2019) Designing dual inhibitors of anaplastic lymphoma kinase (ALK) and bromodomain-4 (BRD4) by tuning kinase selectivity. J Med Chem: published online 21 February 2019. http://dx.doi.org/10.1021/acs.jmedchem.8b01947
Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M (2019) Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. eLife 8: e42549. http://dx.doi.org/10.7554/eLife.42549
Wiesemann K, Simm S, Mirus O, Ladig R, Schleiff E (2019) Regulation of two GTPases Toc159 and Toc34 in the translocon of the outer envelope of chloroplasts. Biochim Biophys Acta Proteins Proteom: published online 3 January 2019. http://dx.doi.org/10.1016/j.bbapap.2019.01.002
Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S (2019) A chemical toolbox for the study of bromodomains and epigenetic signaling. Nat Commun 10: 1915. http://dx.doi.org/10.1038/s41467-019- 09672-2
Yoga EG, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V (2019) Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics. Biochim Biophys Acta Bioenerg 1860: 573-581. http://dx.doi.org/10.1016/j.bbabio.2019.06.006
12 Yuki KE, Marei H, Fiskin E, Eva MM, Gopal AA, Schwartzentruber JA, Majewski J, Cellier M, Mandl JN, Vidal SM, Malo D, Dikic I (2019) CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nat Microbiol: published online 8 July 2019. http://dx.doi.org/10.1038/s41564-019-0484-8
Zakrzewska S, Mehdipour AR, Malviya VN, Nonaka T, Koepke J, Muenke C, Hausner W, Hummer G, Safarian S, Michel H (2019) Inward-facing conformation of a multidrug resistance MATE family transporter. Proc Natl Acad Sci USA: published online 3 June 2019. http://dx.doi.org/10.1073/pnas.1904210116
Zerkalenkova E, Lebedeva S, Kazakova A, Tsaur G, Starichkova Y, Timofeeva N, Soldatkina O, Aprelova E, Popov A, Ponomareva N, Baidun L, Meyer C, Novichkova G, Maschan M, Maschan A, Marschalek R, Olshanskaya Y (2019) Acute myeloid leukemia with t(10;11)(p11-12;q23.3): results of Russian pediatric AML registration study. Int J Lab Hematol: published online 9 January 2019. http://dx.doi.org/10.1111/ijlh.12969
Zhu G, Zeng H, Zhang S, Juli J, Pang X, Hoffmann J, Zhang Y, Morgner N, Zhu Y, Peng G, Michel H, Sun F (2019) A 3.3 A- Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of its Thermal Stability. Angew Chem Int Ed Engl: Published online 28 November 2019. http://dx.doi.org/10.1002/anie.201911554
Zozulia O, Bachmann T, Deussner-Helfmann NS, Beierlein F, Heilemann M, Mokhir A (2019) Red light-triggered nucleic acid- templated reaction based on cyclic oligonucleotide substrates. Chem Commun published online 12 August 2019. http://dx.doi.org/10.1039/c9cc03587g
2018
Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, Bjornstad A, Henneke L, Gartner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW (2018) Biallelic mutations in NDUFA6 establish its role in early-onset isolated mitochondrial complex I deficiency. Am J Hum Genet: published online 20 September 2018. http://dx.doi.org/10.1016/j.ajhg.2018.08.013
Ardèvol A, Hummer G (2018) Retinal isomerization and water-pore formation in channelrhodopsin-2. Proc Natl Acad Sci USA 115: 3557-3562. http://dx.doi.org/10.1073/pnas.1700091115
Atzori A, Malviya VN, Malloci G, Dreier J, Pos KM, Vargiu AV, Ruggerone P (2018) Identification and characterization of carbapenem binding sites within the RND-transporter AcrB. BBA-Biomembr 1861: 62-74. http://dx.doi.org/10.1016/j.bbamem.2018.10.012
Bains JK, Blechar J, de Jesus V, Meiser N, Zetzsche H, Fürtig B, Schwalbe H, Hengesbach M (2018) Combined smFRET and NMR analysis of riboswitch structural dynamics. Methods 153: 22-34. http://dx.doi.org/10.1016/j.ymeth.2018.10.004
Bartelt SM, Chervyachkova E, Steinkühler J, Ricken J, Wieneke R, Tampé R, Dimova R, Wegner SV (2018) Dynamic blue light- switchable protein patterns on giant unilamellar vesicles. Chem Commun: published online 10 January 2018. http://dx.doi.org/10.1039/c7cc08758f
Barth K, Hank S, Spindler PE, Prisner TF, Tampé R, Joseph B (2018) Conformational coupling and trans-inhibition in the human antigen transporter ortholog TmrAB resolved with dipolar EPR spectroscopy. J Am Chem Soc 140: 4527-4533. http://dx.doi.org/10.1021/jacs.7b12409
Becker Y, Unger E, Fichte MAH, Gacek DA, Dreuw A, Wachtveitl J, Walla PJ, Heckel A (2018) A red-shifted two-photon-only caging group for three-dimensional photorelease. Chem Sci 9: 2797-2802. http://dx.doi.org/10.1039/c7sc05182d
13 Beckert B, Acker-Palmer A, Volknandt W (2018) Abeta42 oligomers impair the bioenergetic activity in hippocampal synaptosomes derived from APP-KO mice. Biol Chem: published online 1 February 2018. http://dx.doi.org/10.1515/hsz-2017- 0238
Bergs A, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A, Liewald JF (2018) Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans. PLoS One 13: e0191802. http://dx.doi.org/10.1371/journal.pone.0191802
Betzer C, Lassen LB, Olsen A, Kofoed RH, Reimer L, Gregersen E, Zheng J, Cali T, Gai WP, Chen T, Moeller A, Brini M, Fu Y, Halliday G, Brudek T, Aznar S, Pakkenberg B, Andersen JP, Jensen PH (2018) Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation. EMBO Rep 19: http://dx.doi.org/10.15252/embr.201744617
Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schurmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I (2018) Cystathionine gamma lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis. Circulation: published online 3 July 2018. http://dx.doi.org/10.1161/circulationaha.118.034757
Bock C, Löhr F, Tumulka F, Reichel K, Würz J, Hummer G, Schäfer L, Tampé R, Joseph B, Bernhard F, Dötsch V, Abele R (2018) Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL. Sci Rep 8: 15662. http://dx.doi.org/10.1038/s41598-018-33841-w
Boeckel JN, Palapies L, Klotsche J, Zeller T, von Jeinsen B, Perret MF, Kleinhaus SL, Pieper L, Tzikas S, Leistner D, Bickel C, Stalla GK, Lehnert H, Lindahl B, Wittchen HU, Silber S, Baldus S, Maerz W, Dimmeler S, Blankenberg S, Münzel T, Zeiher AM, Keller T (2018) Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain. Sci Rep 8: 8087. http://dx.doi.org/10.1038/s41598-018-26120-1
Boeckel JN, Perret MF, Glaser SF, Seeger T, Heumuller AW, Chen W, John D, Kokot KE, Katus HA, Haas J, Lackner MK, Kayvanpour E, Grabe N, Dieterich C, von Haehling S, Ebner N, Hunecke S, Leuschner F, Fichtlscherer S, Meder B, Zeiher AM, Dimmeler S, Keller T (2018) Identification and regulation of the long non-coding RNA Heat2 in heart failure. J Mol Cell Cardiol 126: 13-22. http://dx.doi.org/10.1016/j.yjmcc.2018.11.004
Borisova ME, Voigt A, Tollenaere MAX, Sahu SK, Juretschke T, Kreim N, Mailand N, Choudhary C, Bekker-Jensen S, Akutsu M, Wagner SA, Beli P (2018) p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun 9: 1017. http://dx.doi.org/10.1038/s41467-018-03417-3
Bourdeaux F, Hammer CA, Vogt S, Schweighofer F, Noll G, Wachtveitl J, Grininger M (2018) Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin. ACS Infect Dis: published 2 April 2018. http://dx.doi.org/10.1021/acsinfecdis.7b00237
Bowkett D, Talon R, Tallant C, Schofield C, von Delft F, Knapp S, Bruton G, Brennan PE (2018) Identifying small-molecule binding sites for epigenetic proteins at domain-domain interfaces. ChemMedChem: published online 17 April 2018. http://dx.doi.org/10.1002/cmdc.201800030
Brassesco MS, Valera ET, Meyer C, Marschalek R, Lopes BA, Queiroz RGP, Calado RT, Scrideli CA, Tone LG (2018) A new complex rearrangement in infant ALL: t(X;11;17)(p11.2;q23;q12). Cancer Genet 228-229: 110-114. http://dx.doi.org/10.1016/j.cancergen.2018.10.006
Braun S, Enculescu M, Setty ST, Cortes-Lopez M, de Almeida BP, Sutandy FXR, Schulz L, Busch A, Seiler M, Ebersberger S, Barbosa-Morais NL, Legewie S, König J, Zarnack K (2018) Decoding a cancer-relevant splicing decision in the RON proto- oncogene using high-throughput mutagenesis. Nat Commun 9: 3315. http://dx.doi.org/10.1038/s41467-018-05748-7
Brown J, Behnam R, Coddington L, Tervo DGR, Martin K, Proskurin M, Kuleshova E, Park J, Phillips J, Bergs ACF, Gottschalk A, Dudman JT, Karpova AY (2018) Expanding the optogenetics toolkit by topological inversion of rhodopsins. Cell: published online 18 October 2018. http://dx.doi.org/10.1016/j.cell.2018.09.026
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Brzozowska E, Lesniewski A, Sek S, Wieneke R, Tampe R, Gorska S, Jönsson-Niedziolka M, Niedziolka-Jönsson J (2018) Interactions of bacteriophage T4 adhesin with selected lipopolysaccharides studied using atomic force microscopy. Sci Rep 8: 10935. http://dx.doi.org/10.1038/s41598-018-29383-w
Cabrera-Orefice A, Yoga EG, Wirth C, Siegmund K, Zwicker K, Guerrero-Castillo S, Zickermann V, Hunte C, Brandt U (2018) Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps. Nat Commun 9: 4500. http://dx.doi.org/10.1038/s41467-018-06955-y
Camgoz A, Paszkowski-Rogacz M, Satpathy S, Wermke M, Hamann MV, von Bonin M, Choudhary C, Knapp S, Buchholz F (2018) STK3 is a therapeutic target for a subset of acute myeloid leukemias. Oncotarget 9: 25458-25473. http://dx.doi.org/10.18632/oncotarget.25238
Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ (2018) Targeting Pim Kinases and DAPK3 to control hypertension. Cell Chem Biol: published online 19 July 2018. http://dx.doi.org/10.1016/j.chembiol.2018.06.006
Chang C, Young LN, Morris KL, von Bulow S, Schoneberg J, Yamamoto-Imoto H, Oe Y, Yamamoto K, Nakamura S, Stjepanovic G, Hummer G, Yoshimori T, Hurley JH (2018) Bidirectional control of autophagy by BECN1 BARA domain dynamics. Mol Cell: published online 20 December 2018. http://dx.doi.org/10.1016/j.molcel.2018.10.035
Cossio P, Allegretti M, Mayer F, Müller V, Vonck J, Hummer G (2018) Bayesian inference of rotor ring stoichiometry from electron microscopy images of archaeal ATP synthase. Microscopy: published online 19 July 2018. http://dx.doi.org/10.1093/jmicro/dfy033
Cossio P, Hummer G (2018) Likelihood-based structural analysis of electron microscopy images. Curr Opin Struct Biol 49: 162-168. http://dx.doi.org/10.1016/j.sbi.2018.03.004
Cossio P, Hummer G, Szabo A (2018) Transition paths in single-molecule force spectroscopy. J Chem Phys 148: 123309. http://dx.doi.org/10.1063/1.5004767
Coutinho ID, Henning LMM, Dopp SA, Nepomuceno A, Moraes LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA (2018) Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia. Data Brief 21: 1089-1100. http://dx.doi.org/10.1016/j.dib.2018.09.122
Cremer S, Michalik KM, Fischer A, Pfisterer L, Jaé N, Winter C, Boon RA, Muhly-Reinholz M, John D, Uchida S, Weber C, Poller W, Günther S, Braun T, Li DY, Maegdefessel L, Matic Perisic L, Hedin U, Soehnlein O, Zeiher A, Dimmeler S (2018) Hematopoietic deficiency of the long non-coding RNA MALAT1 promotes atherosclerosis and plaque inflammation. Circulation: published online 28 November 2018. http://dx.doi.org/10.1161/circulationaha.117.029015
Cruz-Leon S, Vazquez-Mayagoitia A, Melchionna S, Schwierz N, Fyta M (2018) Coarse-grained double-stranded RNA model from quantum-mechanical calculations. J Phys Chem B 122: 7915-7928. http://dx.doi.org/10.1021/acs.jpcb.8b03566
Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D (2018) BAG3 overexpression and cytoprotective autophagy mediate apoptosis resistance in chemoresistant breast cancer cells. Neoplasia 20: 263-279. http://dx.doi.org/10.1016/j.neo.2018.01.001
D'Ascenzio M, Pugh KM, Konietzny R, Berridge G, Tallant C, Hashem S, Monteiro O, Thomas JR, Schirle M, Knapp S, Marsden B, Fedorov O, Bountra C, Kessler BM, Brennan PE (2018) An activity-based probe targeting non-catalytic, highly conserved amino acid residues within bromodomains. Angew Chem Int Ed: published online 27 December 2018. http://dx.doi.org/10.1002/anie.201807825
Davies KM, Blum TB, Kühlbrandt W (2018) Conserved in situ arrangement of complex I and III2 in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants. P Natl Acad Sci USA 115: 3024-3029. http://dx.doi.org/10.1073/pnas.1720702115
15
De Vos O, Venable RM, Van Hecke T, Hummer G, Pastor RW, Ghysels A (2018) Membrane permeability: Characteristic times and lengths for oxygen and a simulation-based test of the inhomogeneous solubility-diffusion model. J Chem Theory Comput: published online 12 June 2018. http://dx.doi.org/10.1021/acs.jctc.8b00115
Deussner-Helfmann NS, Auer A, Strauss MT, Malkusch S, Dietz MS, Barth HD, Jungmann R, Heilemann M (2018) Correlative single-molecule FRET and DNA-PAINT imaging. Nano Lett 18: 4626-4630. http://dx.doi.org/10.1021/acs.nanolett.8b02185
Di Rita A, Peschiaroli A, P DA, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F (2018) HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKalpha. Nat Commun 9: 3755. http://dx.doi.org/10.1038/s41467-018- 05722-3
Diederichs T, Nguyen QH, Urban M, Tampé R, Tornow M (2018) Transparent nanopore cavity arrays enable highly parallelized optical studies of single membrane proteins on chip. Nano Lett 18: 3901-3910. http://dx.doi.org/10.1021/acs.nanolett.8b01252
Dong F, Rues RB, Kazemi S, Dötsch V, Bernhard F (2018) Molecular determinants for ligand selectivity of the cell-free synthesized human endothelin B receptor. J Mol Biol: published online 18 October 2018. http://dx.doi.org/10.1016/j.jmb.2018.10.006
Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T (2018) PHD3 controls lung cancer metastasis and resistance to EGFR inhibitors through TGFalpha. Cancer Res: published online 16 January 2018. http://dx.doi.org/10.1158/0008-5472.can-17-1346
Dörraum AR, Kochen L, Langer JD, Schuman EM (2018) Local and global influences on protein turnover in neurons and glia. eLife 7: e34202. http://dx.doi.org/10.7554/eLife.34202
Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Ecke A, Abou-El-Ardat K, Schmid T, Brune B, Wagner S, Serve H, Hoffmann J, Seeger F, Dimmeler S, Zeiher AM, Rieger MA (2018) Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure. JAMA Cardiol: published online 19 December 2018. http://dx.doi.org/10.1001/jamacardio.2018.3965
Dutta D, Debnath M, Muller D, Paul R, Das T, Bessi I, Schwalbe H, Dash J (2018) Cell penetrating thiazole peptides inhibit c- MYC expression via site-specific targeting of c-MYC G-quadruplex. Nucleic Acids Res: published online 14 May 2018. http://dx.doi.org/10.1093/nar/gky385
Dworak L, Roth S, Scheffer MP, Frangakis AS, Wachtveitl J (2018) A thin CdSe shell boosts the electron transfer from CdTe quantum dots to methylene blue. Nanoscale: http://dx.doi.org/10.1039/c7nr08287h
Eisinger ML, Nie L, Dörrbaum AR, Langer JD, Michel H (2018) The xenobiotic extrusion mechanism of the MATE transporter NorM_PS from Pseudomonas stutzeri. J Mol Biol: published online 16 March 2018. http://dx.doi.org/10.1016/j.jmb.2018.03.012
Elamri I, Heumuller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E, Schwalbe H (2018) A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons. Chembiochem: published online 12 October 2018. http://dx.doi.org/10.1002/cbic.201800408
Eltsov M, Grewe D, Lemercier N, Frangakis A, Livolant F, Leforestier A (2018) Nucleosome conformational variability in solution and in interphase nuclei evidenced by cryo-electron microscopy of vitreous sections. Nucleic Acids Res: published online 25 July 2018. http://dx.doi.org/10.1093/nar/gky670
Enßle JC, Boedicker C, Wanior M, Vogler M, Knapp S, Fulda S (2018) Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells. Cancer Lett: published online 27 April 2018. http://dx.doi.org/10.1016/j.canlet.2018.04.032
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Faqar-Uz-Zaman SF, Heinicke U, Meister M, Vogler M, Fulda S (2018) BCL-xL-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis. Cancer Lett 412: 131-142. http://dx.doi.org/10.1016/j.canlet.2017.09.025
Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C (2018) A selective ER- phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J: published online 17 December 2018. http://dx.doi.org/10.15252/embj.201899847
Forster M, Chaikuad A, Dimitrov T, Döring E, Holstein J, Berger BT, Gehringer M, Ghoreschi K, Müller S, Knapp S, Laufer SA (2018) Development, optimization, and structure-activity relationships of covalent-reversible JAK3 inhibitors based on a tricyclic imidazo[5,4- d]pyrrolo[2,3- b]pyridine scaffold. J Med Chem: http://dx.doi.org/10.1021/acs.jmedchem.8b00571
Fragkostefanakis S, Simm S, El-Shershaby A, Hu Y, Bublak D, Mesihovic A, Darm K, Mishra SK, Tschiersch B, Theres K, Scharf C, Schleiff E, Scharf KD (2018) The repressor and co-activator HsfB1 regulates the major heat stress transcription factors in tomato. Plant Cell Environ: published online 6 September 2018. http://dx.doi.org/10.1111/pce.13434
Fuhrmann DC, Wittig I, Brüne B (2018) TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF- 1alpha stabilization and IL-1beta expression. Redox Biol 20: 204-216. http://dx.doi.org/10.1016/j.redox.2018.10.007
Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci: published online 20 February 2018. http://dx.doi.org/10.1007/s00018-018-2779-y
Gao Y, Spahn C, Heilemann M, Kenney LJ (2018) The pearling transition provides evidence of force-driven endosomal tubulation during Salmonella infection. mBio 9: e01083-18. http://dx.doi.org/10.1128/mBio.01083-18
Garcia-Lopez A, Tessaro F, Jonker HRA, Wacker A, Richter C, Comte A, Berntenis N, Schmucki R, Hatje K, Petermann O, Chiriano G, Perozzo R, Sciarra D, Konieczny P, Faustino I, Fournet G, Orozco M, Artero R, Metzger F, Ebeling M, Goekjian P, Joseph B, Schwalbe H, Scapozza L (2018) Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat Commun 9: 2032. http://dx.doi.org/10.1038/s41467-018-04110-1
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Gatterdam K, Joest EF, Gatterdam V, Tampé R (2018) Scaffold design of trivalent chelator heads dictates high-affinity and stable His-tagged protein labeling in vitro and in cellulo. Angew Chem Int Ed: published online 29 May 2018. http://dx.doi.org/10.1002/anie.201802746
Georgi V, Schiele F, Berger BT, Steffen A, Marin Zapata PA, Briem H, Menz S, Preusse C, Vasta JD, Robers MB, Brands M, Knapp S, Fernandez-Montalvan A (2018) Binding kinetics survey of the drugged kinome. J Am Chem Soc: published online 26 October 2018. http://dx.doi.org/10.1021/jacs.8b08048
Gewering T, Januliene D, Ries AB, Moeller A (2018) Know your detergents: A case study on detergent background in negative stain electron microscopy. J Struct Biol: published online 29 May 2018. http://dx.doi.org/10.1016/j.jsb.2018.05.008
Geyer N, Ridzewski R, Bauer J, Kuzyakova M, Dittmann K, Dullin C, Rosenberger A, Schildhaus HU, Uhmann A, Fulda S, Hahn H (2018) Different response of Ptch mutant and Ptch wildtype rhabdomyosarcoma toward SMO and PI3K inhibitors. Front Oncol 8: 396. http://dx.doi.org/10.3389/fonc.2018.00396
Giannoulis A, Ackermann K, Spindler PE, Higgins C, Cordes DB, Slawin AMZ, Prisner TF, Bode BE (2018) Nitroxide-nitroxide and nitroxide-metal distance measurements in transition metal complexes with two or three paramagnetic centres give access to
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