The Destinies and Destinations Meeting Review of Rnas
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Cell, Vol. 95, 451±460, November 13, 1998, Copyright 1998 by Cell Press The Destinies and Destinations Meeting Review of RNAs Tulle Hazelrigg GMC. Since Prospero is independently localized to the Department of Biological Sciences GMC, is prospero mRNA localization gratuitous? The Columbia University answer is no. While staufen mutants alone are not defec- New York, New York 10027 tive in GMC differentation, staufen is important for GMC fate, since staufen mutations enhance defects in GMC fate caused by hypomorphic prospero alleles. Thus, this The third biennial FASEB Summer Research Confer- binary cell fate decision appears to be controlled redun- ence, ªIntracellular RNA Sorting, Transport, and Local- dantly by localization of both prospero mRNA and Pros- ization,º was held June 6±11 in Snowmass, Colorado. pero to the GMC daughter cell. Topics included the biological functions of localized Early Embryonic Development RNAs, the nature of nuclear±cytoplasmic RNA transport, Several mRNAs are localized to the animal or vegetal the role of signaling pathways in RNA localization, the poles of the Xenopus oocyte, and some are implicated nature of cis-acting localization elements within RNAs, in axial patterning of the embryo (reviewed in Schnapp the proteins that bind these elements, and the cellular et al., 1997). Mary Lou King (University of Miami Medical mechanisms that achieve cytoplasmic transport and an- School) presented definitive evidence for an essential choring of RNAs to specific domains within cells. role of one vegetally localized mRNA, VegT mRNA, in early embryogenesis.
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