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WO 2018/118197 Al 28 June 2018 (28.06.2018) W !P O PCT

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WO 2018/118197 Al 28 June 2018 (28.06.2018) W !P O PCT (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/118197 Al 28 June 2018 (28.06.2018) W !P O PCT (51) International Patent Classification: Published: A23K 20/116 (2016.01) A61K 31/568 (2006.01) — with international search report (Art. 21(3)) A61K 31/352 (2006.01) (21) International Application Number: PCT/US20 17/056685 (22) International Filing Date: 14 October 2017 (14.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/437,239 2 1 December 20 16 (2 1. 12.20 16) US 62/482,196 26 July 2017 (26.07.2017) US (72) Inventor; and (71) Applicant: POSTREL, Richard [US/US]; 5244 N. Bay Rd, Miami Beach, FL 33 140 (US). (74) Agent: JONES, George; 11761 North Shore Dr, Reston, VA 20190 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (54) Title: HEALTHIER AGING IN DOMESTICATED ANIMALS (57) Abstract: This invention provides compositions, systems and methods that improve and/or optimize the health and performance of animals, especially mammals including humans, canines, equines, felines, etc. Key aspects of the principle invention and its parts include the monitoring, management and modulation of the body's natural cannabinoid systems through its native mechanisms thereby optimizing its processes by supplementation with endogenously occurring components and/or by administering synthetic compounds. — The invention selects from multiple available resources to modify and/or rebalance an individual system or it may be applied across interconnected systems. The encompassing system that is intricately involved in the operations and intensities, e.g., the balancing of most other systems of our bodies, relates to cannabinoid compounds and their receptors. The cannabinoid pathways can be coordinated in rebalancing multiple and various metabolic pathways. Extending Life and Its Vitality BACKGROU ND Qua lity of life, especia lly in mam mals, is extended using thera pies relating to aging, food allergies, pain and reduced vigor. These thera pies as set forth in describing the invention reba la nce molecu la r, cel lu lar and subcel lular biochemica l requirements of mitochondria and other organel le processes Mam mals are large com plex organisms made of tril lions of cel ls. These cel ls com prise high ly specia lized differentiated cel ls and less differentiated cel ls that might act as stem cel ls to produce one or more high ly specia lized differentiated cell. The cells differentiate t o maximize their abilities for assigned tasks while leaving other essentia l functions to other specia lized cel ls. The cel ls specia lize by emphasizing certain activities and eschewing others. They do this by selective induction of the proteins the individua l cel l makes and uses. We categorize cel ls, tissues, enzymes, etc. by assigning by designating them as belonging to one of more systems - i.e., groups interacting t o perform related functions. For exa mple, the respiratory system has the task of ha rvesting oxygen and disposing of carbon dioxide. The respiratory system has severa l su bsystems including the lu ngs and their alveoli that exchange gas molecu les in air with those dissolved in blood. It also includes a pa rt of the muscu lar system, the muscles that pu mp the air in and out of the alveoli. There is another subsystem, part of the respiratory system that provides the mucous and keeps the cell su rfaces healthy and damp. The cells of the lu ng each have ion excha nge systems that maintain cell volu me and are importa nt for muscle movement and secretions. The respiratory system is but one "system" of the com plex mam malia n body. Animals also need a circulatory system, a lym phatic system, a digestive system, an immu ne system, an integu menta ry system, a skeleta l system, a muscular system, a nervous system, a urina ry system, an endocrine system and a reproductive system. Each of these systems com prises multiple layers of su bsystems. Specia lized grou ping of cel ls performing related tasks are assem bled into structures ca lled orga ns. Many orga ns and their cel ls ca n be pa rticipa nts in more than one system. Coordinating the various systems t o act in concert for the survival of the orga nism is a complicated task requiring consta nt monitoring and rebala ncing activities of the numerous su bsystems and their su bsystems and the individua l cel ls that perform the systemic tasks. Each cel l itself is required t o accom plish several functions. The plasma membra ne sepa rates the cell from the outside; regions withi n the cel l, e.g., nucleus, golgi, endoplasmic reticulum, mitochond ria, etc. have specia lized functions that they perform. Nutrients must be internalized, while harmfu l or unnecessa ry compounds must be excluded. The right proteins must be made at the right time and delivered to the right place. Every reaction involves chemica l and physical energy which must be available. The intracellu lar systems or activities like those of the la rger orga nism, also involve com plicated bala ncings and rebalancings t o meet im mediate needs of the cel l, the orga n and the animal. This system of consta nt reba la ncings has t o be almost insta nta neously flexible for ra pid response t o the thousa nds of chemica l reactions occu rring every second. One importa nt vector system for the control and reba la ncing tasks uses several compou nds, such as ana nda mide, 2- arachidonoylglycerol and their receptors. These were the first two com pou nds identified as players in our endoca nna binoid system. There are severa l other cannabinoids now identified that bind these receptors or one of severa l other receptors now identified as active in the can na binolic systems. Mam malia n cel ls are eukaryotic cel ls and therefore, like in euka ryotic organisms genera lly, these cells and their host orga nisms rely on their mitochondria t o produce adenosine triphosphate (ATP). Mitochondria (a nd chloroplasts in plants) have their own genomes, DNA genes, that replicate independently from DNA of a cel l's nucleus. But the mitochondrial genome only provides coding instruction for 1% of the proteins that are active in a mitochond rion. This is another illustration of the interdependence between the meta bolic pathways in a cel l. Virtua lly all processes of the orga nisms and of each of the cel ls of each organism require numerous overlapping pathways for continuing life and function of the organism. The overlapping pathways ca nnot be considered in isolation. All pathways require severa l inputs of energy. At a minimu m, every protein involved in a pathway required energy from high energy phosphate molecules for its synthesis. The energy source most often is mitochond ria lly derived ATP. Enzymatic reactions are genera lly cou pled with ATPase or GTPase activities that drive the biochemica l reactions. The mitochondria themselves can not exist in isolation. The majority of the proteins and lipids constituting the mitochondrial meta bolic machinery, its transport protei ns, enzymes and membra nes, are provided by the hea lthy operation of numerous cel l pathways that themselves are reliant on mitochond rial ATP production. The systems must coordinate to provide the pa rts t o the other systems o n demand. When one system malfunctions one o r more back-up systems must alter their operations to meet the new needs. Aging is a progression of seria l brea kdown events, general ly commencing with one of the cells in a system failing t o meet the needs of other cells. Each breakdown requires opportu nistic remedies t o add ress each minor failing. Cumu latively, the agi ng process is a gradua l decline, as back-up after back-up is activated. But each back-u p is less efficient tha n the previous with the result that performa nce conti nuously declines, the decline accelerates and vitality eva porates. When remaining back-ups are insufficient, death of cel ls, their tissues/orga ns, and eventual ly of the organism itself, results.
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