The Academic Centre for Dentistry Amsterdam

ANNUAL RESEARCH REPORT 2015

Annual Research Report 2015

Edited by : T.J.M. van Steenbergen, H.S. Brand and F.M. Meijer, ACTA Design cover : Facilitaire dienst, ACTA Cover : Department of Dental Materials Sciences, ACTA

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CONTENTS page

INTRODUCTION 4

REPORT OF THE DEAN 5

The Research Institute ACTA 5 Evaluation of the research program 5 Summary of research output and input 6 Societal impact 9 Management 10 PhD students 11 Points of attention 13 Conclusion 13

DESCRIPTION OF PROGRAMS AND RESULTS

Oral Infections and Inflammation 14

Oral Regenerative Medicine 59

Other research, including education related research 103

APPENDIX: Impact factors of SCI journals for ACTA publications 106 Name Index 107

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INTRODUCTION

ACTA is the combined Faculty of Dentistry of the University of Amsterdam (UvA) and the VU University Amsterdam. ACTA has a unique position in the Netherlands, being a combined faculty of two universities since 1984. The boards of both the University of Amsterdam and the Vrije Universiteit Amsterdam share the responsibility for the research at ACTA. Research at ACTA is organized in the ACTA Dental Research Institute.

The annual report starts with chapters containing the annual survey of the dean, and overviews of the scientific activities. As in preceding years the scientific performance is subsequently presented for each programme. Detailed information is given of dissertations, scientific publications in refereed journals, other scientific publications, professional publications, indicators of esteem, collaborations and societal impact.

In 2014 an international review committee evaluated the two research programs of ACTA. Both programmes“Oral Infections and Inflammation” and “Oral Regenerative Medicine” received a very good to excellent rating.

An overview of the scientific output in 2015 is presented in Table 1. We are pleased to note that the output in 2015 was high. The number of publications in refereed scientific journals and the IF-sum have considerably increased during the last years. In 2015 the highest number of scientific publications and a very high impact factor sum was accomplished. In 2015 a total of 15 PhD theses were published and defended.

Research Institute ACTA prof.dr. A.J. Feilzer dean dr. T.J.M. van Steenbergen co-ordinator of research dr. H.S. Brand co-ordinator of research

Address ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam The Netherlands

tel: +31-20-5980641 e-mail: [email protected]

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REPORT OF THE DEAN

The Research Institute ACTA  mission statement Dental research at ACTA focuses on the study of health and diseases of essentially all tissues of the oral cavity, the masticatory system and of oral fluids. Besides infectious diseases like dental caries, periodontal and periapical inflammatory processes, and inflammatory processes around dental implants, attention is paid to the development, function and regenerative capacities of the hard tissues, pain and dysfunction of the masticatory system, and diseases of salivary glands and oral mucosa. It is the general aim to improve strategies for diagnosis, treatment indication and treatment planning as well as prevention of diseases, functional repair of the affected tissues in and around the oral cavity and evaluation of therapies developed to treat patients. Moreover, we aim to gain insight in the aetiology and pathology as well as the risk factors involved in these diseases. In our attempts to fulfil this mission we aim to establish: - integration of the clinical sciences with fundamental disciplines - education and further academic training of post-graduate and PhD-students - knowledge transfer and improvement of the quality of the research in ACTA with special attention to the translation of the results into applications in clinical dentistry. To this end there is a vivid interaction with professional dental organizations and industries.

 positioning of the research institute National position. ACTA comprises the combined Faculties of Dentistry of the University of Amsterdam and the Vrije Universiteit Amsterdam. The ACTA Research Institute is the only institute for research of the faculty. Research programs. From 2011, ACTA research has been organized into the two research programmes (see below). Next to these two major programmes, some limited other research is performed, which is mainly education-related. The programme “Oral Infections and Inflammation” (OII) focuses on (i) the aetiology, prevention and therapy of oral infections such as caries, periodontal and endodontic infections, on (ii) oral inflammatory processes, protective functions of saliva, oral cancer and on (iii) the definition of a normal, healthy oral cavity including psychosocial factors. The programme “Oral Regenerative Medicine” (ORM) focuses on (i) the biological process of adaptation and repair of teeth, bone, mucosa and periodontium, on (ii) the biocompatibility of dental materials, and on (iii) regenerating damaged oral tissue by means of stem cell therapy and/or tissue engineering techniques, taking into account the mechanical threats of the masticatory system. ACTA research on oral regenerative medicine is also included in the interfaculty MOVE Research Institute Amsterdam, a collaboration between the faculty of Behavioural and Movement Sciences, the VU University Medical Centre (VUmc) and ACTA.

 description of output, leading scientific journals in the field Within both research programmes considerable differences exist in the approaches used; yet, both range from fundamental medical-biological to clinical-applied science. This is reflected by the type of scientific journals in which ACTA researchers publish. Some groups primarily present their findings in journals read in the dental research community, while others also aim for the general medical-biological literature.

Evaluation of the research program  external evaluation SEP external evaluation. In 2014 an external evaluation of dental research of ACTA was completed according to the Standard Evaluation Protocol designed by the VSNU. Also on behalf of the Board of the Vrije Universiteit Amsterdam, the Board of the University of Amsterdam has appointed as members of the assessment committee: Hans Marchen den Boer (Cavex Holland B.V.), Christopher McCulloch (University of Toronto), Jukka Meurman, chair (University of Helsinki), Mutlu Özcan (University of Zürich), William Wade (Queen Mary University of London). Jan Heijn (BetaText, Bergen NH) served as secretary of the assessment committee. The two research programs of ACTA, “Oral Infections and Inflammation” and “Oral Regenerative Medicine” were evaluated separately with respect to quality of the research, relevance to society and viability. The committee concluded about the program Oral Infections and Inflammation: “The quality of research in this programme was considered excellent. Many strong publications from the OII group have had a considerable impact in the field of dental research and have influenced opinion development on these topics in the broader

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scientific community. The relevance of the group’s research to society was considered to be very good. Collectively the future of the programme was considered to be very good.“ The committee concluded about the program Oral Regenerative Medicine: “Because of the future trajectory and promise provided in particular by the increased integration of cell biology approaches into scaffold development and prosthodontics/ implantology research, the research quality of the ORM programme was considered to be excellent. The ORM programme’s impact on society is considered to be very good. While there are some structural organizational issues that need to be resolved to ensure further integration, research success and ongoing productivity, the group’s viability is considered to be very good.“ The committee gave a number of valuable recommendations that will be elaborated in the next years. to further strengthen the research at ACTA. For more details about this evaluation we refer to the assessment report of the committee. Citation analysis. In 2013, the CWTS in Leiden has performed a bibliometric analysis of the ACTA scientific publications over the years 2001-2011. One of the goals of this study was to identify possible benchmarks. These benchmark candidates were investigated in more detail and compared with the performance of ACTA. The conclusions of this study are as follows: “In this study we developed and applied a method to identify benchmark candidates for institutes with a non- mainstream research profile. These benchmarks are used to position the performance of ACTA. The outcome of this study shows an important role of ACTA in terms of output. ACTA has published an impressive amount of papers during the period studied (1,142 papers). Also the amount of number of citations received is very high (4,667) as well as the number of publications in the top 10% most highly cited (P_top10). It should be noted, however, that the latter two are size-depended: the more you publish, the more citations you will receive. If we look at the impact (MNCS and PP_top10, citations per publication normalized by field), ACTA is among the middle group. Still the impact is well above world average (10%).”

Summary of research output and input

Table 1. Comparison of research indicators 2003-2015

Year 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Dissertations 6 12 11 11 12 13 6 18 15 13 18 13 15

Refereed publications 152 170 166 189 185 214 216 196 199 208 250 255 286 First author from ACTA 106 111 130 131 117 159 132 105 103 117 127 126 161 Other scientific publications 12 8 17 13 6 24 12 18 15 14 16 18 31 Professional publications 93 91 99 114 113 98 168 164 169 132 159 167 175 Publications for general public 8 14 9 12 9 13 31 Impact factor sum 238 273 322 344 354 435 509 434 503 493 696 656 745

Personnel WP 1 47.9 49.4 46.0 46.5 50.3 43.4 40.8 36.7 36.2 39.5 42.2 40.6 38.6 WP2 6.2 6.6 4.8 7.9 7.8 9.6 7.0 7.8 10.1 9.4 6.3 5.9 4.9 WP3 10.3 7.7 6.7 7.4 6.5 5.4 12.9 13.5 14.4 17.6 19.6 19.6 28.1 Guests 2.6 1.9 2.2 4.2 4.3 3.6 pm pm pm pm pm pm pm Total personnel 66.9 65.6 59.8 66.1 68.7 62.1 61.6 57.9 60.7 66.5 68.1 66.1 71.6 wp1 = academic personnel funded by 1st source in fte; this includes direct funding by the university wp2 = academic personnel funded by 2nd source in fte; this includes research grants obtained in national competition from NWO, STW and KNAW wp3 = academic personnel funded by 3rd source in fte; this includes research contracts for specific projects obtained from external organizations, such as industry, governmental ministries, European Commission and charity organizations

 long time performance Dissertations (PhD theses). The performance of the research institute over a longer period is shown in Table 1. These data show that the number of dissertations per year has fluctuated between 6 and 18. This reflects

6 Academic Centre for Dentistry Amsterdam variations in external collaborations, such as non-ACTA employees receiving a PhD from our universities and tenure staff members finishing their PhD. In 2015 15 dissertations were accomplished. PhD performance. The percentage of PhD students that finished their thesis averages at 90 % over the last 20 years, and the mean time period between start of employment and defending the thesis is 4.6 years. This figure is corrected for the 0.6 to 0.8 fte employment of several PhD students and for long leave of absence (e.g. maternity and illness) of some PhD students. Scientific publications. The main attention in the research assessment at the individual and program level is given to publications in scientific journals with a peer review referee system. This category shows a slightly increasing number over the last 20 years, despite a relatively stable input in fte of scientific personnel. The average quality of the publications has significantly improved over the 20-year period, as indicated by the increase of the impact factor sum (Figure 1). In 2015 the highest number of 286 refereed publications and a very high IF sum were obtained. Professional publications. ACTA scientists are very active in communicating their research findings not only to the scientific community, but also to professionals. The number of professional publications in 2015 was 175.

Figure 1. Impact factor sum of ACTA publications, scientific publications in refereed journals, professional publications and total scientific personnel in fte. 800

700

600

IF sum 500 ref publ 400 total fte 300 prof publ

200

100

 notable events in 2015 Publications in high ranking journals. Outstanding contributions for the year 2015 were publications in high ranking biomedical journals, i.e. Lancet Infectious Diseases (impact factor 22.4), JAMA Psychiatry (impact factor 12.1), Clinical Infectious Diseases (impact factor 8.8), and Clinical Cancer Research (impact factor 8.7). ACTA scientists also published many papers in the top 10% journals in dentistry, i.e. 34 papers in the 6 journals with the highest impact factor in this field, among which 6 in the Journal of Dental Research. Impact factors. In addition to the output indicators given, the percentage of papers in high impact journals in the field gives valuable information. ACTA published in total 286 scientific papers in refereed journals, of which 267 in journals with an impact factor (SCI journals). 51% of these 267 papers appeared in journals belonging to the field “Dentistry, Oral Surgery and Medicine”. 24% of all publications were in the top 10% of the journals, 47% in the top 25% and 78% in the top 50% (Table 2). This means that, as in previous years, a relatively large

7 Annual Research Report 2015 number of publications were published in the top journals in the field, both in dental and in non-dental journals. Indicators of esteem. On a personal level a number of ACTA employees rank in the top of the international dental community, as determined by the various indicators of esteem, such as editorships, invited lectures, and congresses organized. In 2015 a total of 20 awards were received by ACTA scientists for their achievements. For more details we refer to the description of the two research programs. Grants. As in previous years ACTA scientists obtained several importants grants. An example of a successful grant is the participation of ACTA in the nationally funded and oriented Top Institute Food and Nutrition (TIFN) in 2011, where a new theme “Oral Health” has been initiated. In this theme, world players in the oral care industry, the chewing gum industry, flavour industry, food industry and (oral) care appliances industry collaborate with ACTA and with the Netherlands Organization for Applied Scientific Research (TNO). Another example is the large EU-MUNDUS project: MOVE-AGE, in which ACTA participates. At this moment two ACTA PhD students are funded by this EU-project. In 2013 a large Marie Curie ITN EU project was granted by the EU. This project, named Euroclast, is coordinated by ACTA and involves participation of seven academies and two industrial partners and a total of 11 PhD students. In 2015, the EU Horizon 2020 Research Program awarded 6 million Euro’s for the project ADVOCATE – Adding value to oral care.

Table 2. Percentage of publications in different quartiles of dentistry and non-dental journals in 2015

dentistry journals non-dental journals all journals

numbers percentage numbers percentage numbers percentage top 10% 39 29 % 24 18 % 63 24 %

Quartile 1 66 49 % 60 46 % 126 47 %

Quartile 2 45 33 % 37 28 % 82 31 %

Quartile 3 23 17 % 26 20 % 49 18%

Quartile 4 2 1 % 8 6 % 10 4 % total 136 100% 131 100% 267 100%

 assessment at the program level When the research at the program level is considered, both programs perform over the last years in general equally well in terms of parameters like input and output (personnel, PhD students, publications, dissertations etc). In 2015 the OII output of the OII programme was higher than the ORM programme, in particuiar with respect to professional publications, see Table 3. Other research (OWI), not related to the two programs, is limited both in terms of input (personnel and budget), and of output. Despite the very limited financial input by ACTA, the education related research is considered valuable.

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Table 3. Summary of the number of publications, impact factor sum and academic personnel in fte

Program Dis Ref publ OSP PP PGP IF wp1 wp2 wp3 wp tot OII 9 161 (66) 22 118 11 451 20,00 0,70 11,25 31,95

ORM 5 140 (83) 10 63 - 315 18,60 4,25 16,00 38,85

OWI - 2 - 2 - 2 - - 0,85 0,85

ACTA* 13 286 (161) 9 175 11 745 38,60 4,95 28,10 71,65

This table summarises the number of scientific publications in refereed journals, the number of other scientific publications, and the number of professional publications. Also the personnel involved in full time equivalent (fte) and the impact factor-sum (IF-sum) are included in this table. The IF-sum was calculated for each program by adding together the impact factor values of all 2015 publications. Dis = number of dissertations Ref publ = number of scientific papers in refereed journals. Between parentheses is the number of first authors belonging to the program in question OSP = other scientific publications (international, refereed) PP = professional publications PGP = publications for the general public IF = sum of impact factors as indexed by ISI. wp1 = academic personnel funded by 1st source in fte wp2 = academic personnel funded by 2nd source in fte wp3 = academic personnel funded by 3rd source in fte wp tot = all academic personnel in fte OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other research * ACTA = the total number of dissertations and papers reflects the total for ACTA; a dissertation or paper was counted only once; the total impact factor sum is not a summation of the data from each program

Table 4: fte of staff and PhD students (see table 2) by type of position

Program Staff PhD students Total 1st 2nd 3rd 1st 2nd 3rd OII 14,75 0,20 5,40 5,25 0,50 5,85 31,95

ORM 11,10 1,65 9,95 7,50 2,60 6,05 38,85

OWI - - 0,10 - - 0,75 0,85

Total 25,85 1,85 15,55 12,75 3,10 12,45 71,65 OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other Research

Societal impact  impact on teaching and dental care The prime societal values of a strong research program in a dental discipline are the effect on teaching and on dental care. The research improves the quality of teaching given at ACTA, both for undergraduate students, graduate students, students participating in the post-initial specialist courses, and for PhD students. New findings and concepts are included in the curriculum at ACTA, but are also presented to dental practitioners at frequently held education activities, e.g. Quality Practice. The Research Institute participates in the ACTA curriculum by offering scientific training to all ACTA dental students. The societal impact of the research of ACTA is also focussed on the influence on patient care, both within ACTA and externally. Research on different

9 Annual Research Report 2015 main areas of interest contributes to improved prevention, diagnosis and treatment of relevant patient groups. The high number of professional publications contributes to this societal impact. In this annual report the societal impact of each research program is described in more detail in the respective chapters.

 functions in the scientific and professional community ACTA employees take an active role as executives in international scientific organizations (86 international functions), as members of editorial boards of scientific journals (78) and in being leading in 'wetenschappelijke verenigingen' of researchers and dental practitioners in the Netherlands. Furthermore, the societal impact is evident from the organization of symposia and conferences in the Netherlands and abroad, presentations for dentists, medical specialists and patient groups, memberships of advisory councils, and frequent contacts with the industry. In addition many scientists are also practising as dentists in specialized clinics at ACTA or in the Amsterdam region. Obviously the societal impact of their activities, individually as clinically active professionals and leading among their peers, should be acknowledged. The societal impact is also evident from the relatively large number of 175 professional publications. Some ACTA researchers also wrote popularising publications aimed at a more general audience. Several research findings were high lightened in the general press.

 invited lectures and congresses organized In 2015 ACTA researchers have again contributed actively in internationally held meetings, workshops and symposiums, both as organizers and participants. A total of 124 lectures were given as ‘invited speaker’ at international congresses and symposia. In addition a large number of presentations were given at international congresses after selection on submission of abstracts and during congresses and symposia for a Dutch or international audience. Due to this large number, congress abstracts are not listed in this annual report. A total of 16 international meetings were organized by ACTA scientists.

Management  finances The overall budget of the research institute is divided into a part controlled directly by the directorate and another part that is allocated to the departments. The institute budget (senso stricto) of k€ 877 is used for the management of the institute, salaries of PhD students, for travel allowances of PhD students, for the organization of courses for PhD students and for printing PhD theses. The research budgets for the departments (in total being k€ 3298) are distributed based on a model containing several parameters, such as external peer review, bibliometric data over the last 5 years, education, PhD theses and external funding. In addition, standard bench fees are issued for PhD students appointed by the research institute. In addition to the university budget (1st source) ACTA scientists were involved in many research projects with external funding. The total amount of research grants (2nd source) was k€ 517, and the total amount of research contracts (3rd source) was k€ 2241.

 personnel The directorate of the institute comprises: prof.dr. A.J. Feilzer, dean and director of research ad interim p.m. dr. T.J.M. van Steenbergen, co-ordinator of research 0.55 fte mrs. F.M. Meijer, secretary 0.60 fte dr. J.A.M. Korfage, research technician (started June 2014) 0.15 fte

The activities of the research institute directorate consist of organizing scientific meetings with presentations of PhD students, the screening of new research projects, the day-to-day interaction with graduate students on practical matters regarding their position, compiling the annual research report, the planning of graduate courses, allocating budgets for research to the departments, controlling the institutes budget and dealing with general correspondence on research issues with UvA, VU etc.

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PhD students The ACTA PhD training program is organized in the ACTA Graduate School of Dentistry (AGSD). As ACTA has no research master training, the AGSD is at the moment limited to the PhD program.

 PhD student appointments In Figure 2 the number of new PhD students at ACTA is shown in the years 1990 to 2015. Over the years, about 23% of all PhD students had a foreign nationality, about half of them from Europe, the rest from other continents. A mean number of about 9 new PhD students were appointed per year. Due to budget restrictions only 8 new PhD students could be appointed in 2015. About 40 % of the PhD students have a dental background (see Table 5). Of all PhD students about 70% is female. The research institute has started a procedure for allocation new PhD positions for the two main research themes. This procedure resulted in 4 grants for new PhD projects in 2015. Two PhD-students started their project within 2015, the other two will begin in 2016.

Figure 2. Numbers of new ACTA PhD students from the Netherlands and other countries

14 12 10 Foreign 8 Dutch

6 numbers of PhD students PhD of numbers 4 2 0

year of entry

Table 5: PhD students by type of undergraduate training program dentistry dentistry biology / psychology medicine other total Dutch other chemistry OII 36 13 10 3 6 8 76

ORM 25 22 15 - 8 4 74

OWI 2 1 - - - - 3

Total 63 36 21 3 14 12 153 OII = Oral Infections and Inflammation ORM = Oral Regenerative Medicine OWI = Education Institute and other research

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 PhD Courses The following courses are organized for PhD students: “Dentistry for non-dentist PhD students”, “Writing and Presenting in English”, “Methodology and Statistics” and “Oral Biology”. Dentistry is a multidisciplinary science and the background of the PhD students of ACTA is diverse. Therefore, most PhD students follow external courses on specific research areas, organized by research schools in other disciplines.

 PhD thesis duration and completion rate Attention has been paid to the problems related to the social security benefits of PhD students and the time that PhD students need to finish their thesis. The mean time between start of the PhD project and the defence of the thesis within ACTA amounts 4.6 years.

Figure 3. Mean duration of completing the thesis of ACTA PhD students related to the year of entry

6,5

5,5

years 4,5

3,5

year of entry

Over the last 20 years, about 90 % of all PhD students in ACTA completed their thesis (Figure 4). The external review committee evaluated the PhD programme in 2014. They concluded: “Following queries about the infrastructure and core facilities, there was strong and unanimous agreement on the effectiveness of the ACTA programme to provide excellent PhD training. The students indicated that their programmes were well- organized and were well-supported to enable fulfilment of their research goals.”

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Figure 4. Percentage of ACTA PhD students completing their thesis related to the year of entry

120

100

40 percenatge 20

year of entry

Points of attention  HRM and retirement In the coming years eight full professors who were active in 2015 will retire, thus giving the opportunity to appoint highly qualified researchers with a focus on one of the two programmes. Due to budget restrictions the number of persons involved in research on university budget (1st source) had to be reduced slightly, despite the fact that both research priority areas receive a substantial grant from the UvA. Fortunately, the fte scientific personnel on grants (in particular 3rd source) increased.

 PhD training The duration of the PhD programme is, like elsewhere in The Netherlands, in general 4 years full time. PhD students with an employee status are generally employed for 4 years full time or for 5 years during 4 days a week. PhD students funded by EU grants are appointed for 3 years. Recently, it has been decided that future PhD students funded by ACTA will also be appointed for 3 years. The research institute has started a procedure for the allocation of new PhD positions for high quality projects which focus at the integration of fundamental and clinical science. This strategy will be continued further, concentrating on the two main research programmes. According to the PhD regulations of both universities the course programme will be formalized with 30 ECTS points and examinations. The integration between the PhD training programme and the post-graduate clinical training programmes for dental specializations, which is limited now to the courses on statistics and oral biology, will be intensified.

Conclusion The research at ACTA has always been characterized by a wide range of different topics that covered most dental disciplines. The present policy is to focus on the two specific research areas with an excellent performance. The analysis of the various parameters of performance shows that the research at ACTA is, despite of budget restrictions, increasingly improving. Future performance will be dependent among others from the success in obtaining 2nd and 3rd source grants.

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Oral Infections and Inflammation

Program Leaders

Prof.dr. B.G. Loos ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980558 E-mail: [email protected]

Prof.dr. W. Crielaard ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980558 E-mail: [email protected]

Full professors

E. Bloemena J.J.M. Bruers J.M. ten Cate T. Forouzanfar

G.J.M.G. v.d. Heijden A. de Jongh B.J.F. Keijser J. de Lange

C. van Loveren F.R. Rozema E.A.J.M. Schulten L.E. Smeele

E.C.I. Veerman G.H.W. Verrips I. van der Waal G.A. van der Weijden

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Introduction

Oral Infections and Inflammation The oral cavity is one of the most infected parts of man. We hardly understand why most people are completely healthy with at least a thousand different species of microorganisms in billions of numbers present in the mouth, while other individuals develop oral infectious diseases, chronic inflammatory processes and other pathologies, including oral cancers. The central research theme “Oral Infections and Inflammation” (OII) focusses on the pathophysiology, epidemiology and (psycho)social aspects of oral infections and inflammation and prevention and treatment of those, as well as defining and understanding the health of the mouth as a complex ecosystem, with applications far beyond the mouth alone. The four topics in this program interact with each other and can be depicted in the schematic diagram below.

Research objectives 1) The healthy oral cavity and good systemic health. Oral health is an essential part of the general health of each person during his or her life. Poor oral health, oral infections and inflammation, oral cancer and other oral pathology, can lead to major health risks and might affect the progression of cardiovascular diseases, diabetes, cancer and cancer dissemination, systemic chronic and acute infections and vital organ failure. Poor oral health leads to a lower quality of life and economic hardship. In collaboration with several industrial partners, the Netherlands Organization for Applied Scientific Research (TNO) and the Top Institute of Food and Nutrition (TIFN), we work on defining “normal” oral health using a molecular biology approach (-omics). At the same time, we investigate the systemic effects of oral infectious processes in relation to atherosclerotic cardiovascular disease and diabetes, both by literature review and with an intervention trial (focus is mainly on changes in the microbiome and in biomarkers of the named systemic diseases). 2) Innate immunity (cells/saliva), and susceptibility for caries and periodontal diseases. Studies into the role of saliva and innate immune cells (oral PMN) in the maintenance of oral health have a prominent place. Several salivary proteins have strong antimicrobial capabilities and have important proteinase inhibitory actions. Synthetic peptide analogues of salivary histatins are tested as broad spectrum antibiotics. The influence of saliva on the interaction of oral microorganisms with oral epithelial cells and the in vitro wound healing capacities of salivary components are also being investigated. We find PMN in rinsing samples and they have antimicrobial functionality and are thought to have an essential role in maintaining oral health. For periodontal diseases, we collaborate in a self-supported European consortium to identify genetic variations, and we model periodontal disease as a complex system (environmental, life style factors, systemic factors, randomness). 3) Epidemiology and pathophysiology of oral cancer. Forms of oral cancer, precursor lesions of oral cancer, particularly leukoplakia, and salivary tumours are studied. Amongst others, the prognostic value of molecular markers is examined with regard to the malignant transformation of leukoplakia, and the role of the human papilloma virus (HPV) has been studied. Poor oral

15 Annual Research Report 2015 health with its concomitant increase in the oral bacterial load, can predispose for oral cancer. Oral infections are independently associated with oral (pre)cancers. Therefore, not only the traditional risk factors smoking and alcohol usage play a role in oral cancer, but also oral bacteria, yeast and virus. Laboratory and clinical studies are ongoing. Intervention in the precursor lesions of oral cancer, particularly leukoplakia, may prevent the development of frank malignancies. Also other odontogenic tumours are studied, with emphasis on ameloblastomas and keratocystic odontogenic tumours. Characterization is also included of salivary gland tumours at the genomic and protein level. 4) Prevention and therapy of oral infections and inflammation. The knowledge that oral infections may have systemic effects, provides a fundamental basis for new cost- effective prevention programs as well as economic and social spin-off product-innovations in the food and oral care products and dental restorative materials. The dental and medical profession is (re)educated with new knowledge on the fundamentals of normal oral health and the risks of having chronic oral inflammatory processes. The formation, structure and properties of oral and dental biofilms are studied, also in relation to tooth and implant structures. In addition, new antimicrobials and peptides have come into focus as caries and periodontitis preventive agents. Studies into the most effective clinical measures to prevent inflammation of the gingiva and mucosa and to control oral health are being conducted, including substantial efforts to reach clinical standards for evidence based dentistry. Part of successful prevention measures is to improve and to maintain the well-being of both regular dental patients and subgroups of patients suffering from (extreme forms of) anxiety or (anticipated) pain or from physical/mental handicaps.

The researchers within the theme “Oral Infections and Inflammation” have an international prominence in the field of oral health and have acquired a global leadership role in the emerging field of complex ecosystems such as the oral cavity; thus understanding of oral infections, inflammatory processes, oral cancer and the definition of a normal, healthy oral cavity including psychosocial factors. We have been awarded a grant from the University of Amsterdam (UvA) (starting date 1-1-2011) and we demonstrated the multiplier effect (both on the academic as well as the economic aspects) by participating in the Top Institute of Food and Nutrition (TIFN) (contract signed December 2011, first year research in 2012, ending date December 2016).

Results obtained Preclinical studies • Several novel machine learning and bioinformatics approaches to tackle “big data”-problems and to extract useful information from large data-sets were implemented. We developed “NGS-eval” a next generation sequencing error analysis and novel sequence variant detection tool, and used co-regularized spectral clustering to get insights in how oral microbial network function. • The molecular biology of oral microorganisms as well as model systems for several oral infections and in vitro analyses of health promoting microbial activity were further studied, developed and exploited. It was shown that supplementation with arginine serves a health-promoting function; it enhances oral microcosm resilience towards acidification and suppresses outgrowth of the opportunistic pathogen Candida. Arginine facilitates stability of oral microbial communities and prevents them from becoming cariogenic. • Also other preventive strategies were studied in model systems; a novel tea polyphenol-modified calcium phosphate nanoparticle and its remineralization potential were studied and importantly it was shown that biofilm layers affect the treatment outcomes of NaF and Nano-hydroxyapatite. • We were able to get a better understanding of how (in vitro) phenotypic differentiation towards commensal and pathogenic oral biofilms progresses and showed in mixed biofilms that the pathogen Enterococcus faecalis benefits from a calcium hydroxide challenge. These insights were translated to treatment protocols and we were able to show that a modified salt solution prevents regrowth in dental root canals and can eliminate persistent bacteria. We obtained a better insight in the mechanisms of fluoride-resistance in oral pathogens by functional genome analyses of Streptococcus mutans and showed that, in vitro Streptococcus oligofermentans can inhibits Streptococcus mutans both neutral pH and cariogenic conditions. • We showed that systemic Staphylococcus aureus infections are mediated by Candida albicans hyphal invasion of mucosal tissue. • During the past couple of years, we have studied the role of tooth-associated fibroblasts in the formation of osteoclasts. These cells were cultured from teeth from healthy subjects and from periodontitis patients, either or not after infections with periodontal pathogens. We have summarized the role of periodontal ligament fibroblasts in osteoclast formation.

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• Monocytes that enter the periodontium have to make the decision whether they differentiate toward macrophages – beneficial for clearing an infection – or towards osteoclasts, the bone-degrading cells that are mobilized during periodontitis. We described that under defined circumstances, osteoclastogenesis insensitivity can be induced, that is overcome in the presence and on bone surfaces. • A recurrent problem in dental practice is peri-implantitis, an inflammatory condition that causes implant loosening. Knowledge on the characteristics of multinucleated giant cells, the cell type that surrounds implants is needed in order to be able to interfere with this process. It turned out that multinucleated giant cells are capable to lyse calcium-phosphate. • Virtual teeth with and without tooth pathology have been developed for use in a virtual learning environment in dental education to evaluate the appearance of these virtual teeth for use in dental education and to compare them with contemporary educational models, such as plastic teeth and extracted human teeth. The results show that the appearance of the virtual teeth was considered more realistic than the appearance of the plastic teeth. The expectation is that the learning opportunities of the virtual teeth are better than of the plastic teeth.

Clinical studies • The oral (microbial) ecology of the healthy oral cavity as well as several oral diseases and preventive strategies were studied by combining expert clinical evaluations and next-generation-sequencing microbial profiling techniques. We determined the long-term effect of antibiotic administration on the human normal oral and intestinal microbiota and found that the same exposure leads to two radically different responses in these human ecosystems. The oral ecosystem is remarkably resilient, whereas there are long- term (sometimes up to a year) microbial shifts in the gut. • We established the inter-individual variation, correlations, and sex-related differences in the salivary biochemistry of young healthy adults. • In a randomized controlled clinical trial, the effect of fixed orthodontic appliances and fluoride mouthwash on the oral microbiome of adolescents was studied. We concluded that, when provided proper oral hygiene is maintained, changes in the oral microbiome composition resulting from orthodontic treatment are minimal and do not negatively affect oral health. We fine-tuned our methodologies by evaluating the effect of propidium monoazide treatment on the measured bacterial composition of clinical samples (after the use of a mouthwash). • We also studied the methicillin-resistant Staphylococcus aureus carriage rate among Italian dental students. • Multi-disciplinary studies within Top Institute Food and Nutrition (TIFN studies) were performed in 2014 and 2015. These showed among 268 systemically healthy young adults interindividual variations, correlations, and sex-related differences in the salivary biochemistry. In addition, correlations between two different methods to score gingival bleeding and the relationship with dental plaque were evaluated. Probing to the bottom of the gingival pockets resulted in significantly more bleeding than running a probe along the gingival margin; this knowledge is important for future clinical trials for which now robust data is available to make the right choice for bleeding indexes. • For and based on the different consensus meetings invited by the National Center for Dental Hygiene Research & Practice, the International Academy of Periodontology and the European Federation of Periodontology papers were written regarding using the best evidence to enhance dental hygiene decision making. Meta reviews for plaque control-home remedies practiced in developing countries, efficacy of homecare regimens for mechanical tooth cleaning in general and inter-dental tooth cleaning for plaque removal in managing gingivitis were conducted. In this line also mouthwashes were evaluated; the results of which were translated into patient brochures. • Several papers based on clinical trials and systematic reviews were published in the scope of prevention of gingival and periodontal and peri-implant diseases. These include, the effect of CPC mouthrinses, CHX gels/mouthrinses, SLS containing dentifrices and the influence of mechanical instruments on the biocompatibility of titanium dental implants surfaces. • We continued our collaborations with the Bandung University in various projects. In one study we tested vitamin C/calcium threonate/citrus flavonoids supplementations in a cohort of well documented periodontally diseased tea plantation workers. The results showed reductions of CRP, HbA1c and after such supplementation, indicating that a healthy diet may be helpful in fortifying host responses to with stand progression of periodontal disease. • Several projects were related to the link between periodontitis and systemic diseases, (cardiovascular diseases and diabetes). To better understand why there is a lack of interdisciplinary care for patients, we

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collaborated with the Slotervaart Hospital, and found that there is a great lack of unconscious willingness to exchange patient data between dentists and internists. Each professional is too much focused within their own professional world, but patients could much more benefit from proper interdisciplinary exchange for better oral ánd metabolic health. Using the ACTA Axium database year a study was initiated to establish the association between periodontitis and cardiovascular diseases in the Netherlands. • There was a continuation of genetic studies in periodontitis: based on pleitropy we found the gene PLASMINOGEN to be associated with both CVD and periodontitis. In a functional study it was shown that certain genotypes for the ANRIL gene were associated with blood plasma levels of CRP. The implications are not clear but give more weight to the associations of periodontist and CVD. • Previous mathematical modeling of periodontitis, was in this report year continued with modeling of peri- implantitis. Also for peri- implantitis it can be concluded that this is a complex condition with non-linear characteristics. • Seven research projects of the section Social Dentistry have been conducted of which three concern intensive international collaborative projects. • Existing extensive network of national and international cooperation in research has been expanded in 2015. Three foreign guest workers were welcomed: England (48 months), Brazil (12 months) and China (24 months). • The project Research Agenda Oral health was launched in 2015. This project is focused on designing a national research agenda through collaboration with practitioners in the oral health and dental care field. • In 2015 the ORA-STEM/H-OME study was started, with the goal to determine the relationship between several oral complications (like oral mucositis and oral graft-versus-host disease), oral health (caries and periodontitis) and biological determinants like the oral microbiome and proteome in stem cell transplant patients. In total 50 autologous and allogeneic stem cell transplant patients are now being followed for a period of 12-18 months after stem cell transplantations. • Systemic diseases and their treatment could lead to consequences for conditions in oral region and vice versa. An user friendly clinical quality tool for the dental professional has been developed and tested, in which data from relevant literature regarding systemic diseases and their oral manifestations can be disclosed. The tool has been validated. • A clinical guideline on the need for antibiotic prophylaxis during dental treatment in patients having orthopedic implants has been developed; this will be a concerted action with dental associations and orthopedic associations. • Patient centered adverse events to cancer treatment were studied in a multicenter design including sepsis, graft versus host disease and stomatitis. The first-line topical treatment for oral mucosal cGVHD was predominantly steroids (91.7 %), and the second preferred treatment was tacrolimus (41.7 %). The preferred treatment for hyposalivation was pilocarpine (41.7 %). The recommended frequency of oral cancer screening varied; half of the providers suggest a follow-up every 6 months. • The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV- related oropharyngeal squamous cell carcinoma was evaluated. The study does not appear to support that HPV is the main contributor to a rising incidence of OPSCC as the effects of changes in smoking and alcohol use cannot be discounted. • Sepsis in head and neck cancer patients treated with chemotherapy and radiation was studied in the literature and a consensus meeting. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics. • Clinical studies investigating optimal root canal fillings and techniques are ongoing. Significantly less porosity was observed in root canals filled with the single cone technique compared to lateral compaction. Root fillings made by a single-cone technique with epoxy or methacrylate-based sealers were as effective in sealing the root canal as a cold lateral technique with epoxy sealer. The bond strength of calcium silicate cements in root canals is differentially influenced by the irrigation protocol and time. Disinfection of the infected root canal system is a crucial step in root canal treatments. Different aspects of irrigation with hypochlorite have been investigated in order to improve the cleaning of the root canal. A dissertation on this subject was successfully defended. As a result of this study an innovative irrigation solution was patented. This will be subject for future research. • Continuing our program on family functioning and dental caries we further investigated the role of the family factors determining the amount of dental caries of children. Better organization of the family, positive involvement, encouragement were positively related to better oral health but the relationship between coercion and dental caries was inverse. The expectation that overweight and caries would be

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related as both may be determined by an inadequate diet was not confirmed. The findings strongly suggest that preventive programs addressing family functioning may contribute to effective dissemination of the preventive message to prevent dental caries. • In an in situ study it was shown that hesperidin significantly protects the dentin collagen matrix against degradation. • Early detection of caries is important for prevention of larges lesions and possibilities to restore with noninvasive manners. Unfortunately, two fluorescence-based intraoral devices (Soprolife and Diagnodent) did not contribute to a better detection of early carious lesions, than conventional inspection. • Based on a relative simple and reproducible histological feature, adenoid cystic carcinomas of the salivary glands can be identified with a relatively poor prognosis. • Based on miRNA profiling in saliva, benign and malignant tumors of the salivary glands can be identified. • A prognostic model for patients with head-and neck squamous cell carcinoma was validates, by which, based upon HPV status, co-morbidity and nodal status groups with relatively favorable, intermediate and poor prognosis are identified.

Academic personnel in 2015 and 2016 Research staff ACTA – OII (Oral Infections and Inflammation) (in full time equivalents) Position Name fte 2015 plan 2016 Funding Bloemena, prof.dr. E. 0,20 0,20 1 Bruers, prof.dr. J.J.M. 0,40 0,40 3 Cate, prof.dr. J.M. ten pm pm guest Crielaard, prof.dr. W. 0,20 0,40 1 Crielaard, prof.dr. W. 0,40 0,20 3 Eijkman, prof. dr. M.A.J. pm pm guest Forouzanfar, prof.dr. T. 0,05 0,05 1 Heijden, prof.dr.G. J.M.G. van der 0,50 0,10 1 Heijden, prof.dr.G. J.M.G. van der 0,20 0,50 3 Jongh, prof.dr. A. de 0,40 0,20 1 Keijser, prof.dr.ir. B.J.F. 0,15 0,20 3 Lange prof.dr. J. de 0,10 0,10 1 Full professors Loos, prof.dr. B.G. 0,40 0,40 1 Loveren, prof.dr. C. van 0,45 0,45 1 Loveren, prof.dr. C. van 0,05 0,05 3 Rozema, prof.dr. F.R. 0,30 0,30 3 Schulten, prof.dr. E.A.J.M. 0,10 0,10 1 Smeele, prof.dr. L.E. 0,10 0,10 3 Veerman, prof.dr. E.C.I. 0,60 0,75 1 Veerman, prof.dr. E.C.I. 0,10 -- 3 Velden, prof.dr. U. van der pm pm guest Verrips, prof.dr. G.H.W. 0,20 0,20 3 Waal, prof.dr. I. van der 0,10 0,10 1 Weijden, prof.dr. G.A. van der 0,20 0,20 1 Weijden, prof.dr. G.A. van der 0,30 0,30 3 Bikker, dr. F.J. 0,70 0,70 1 Gorter dr. R.C. 0,20 0,10 1 Krom, dr. B.P. 0,70 0,70 1 Krom, dr. B.P. 0,10 0,10 3 Senior lecturers Laine, dr. M.L. 0,30 0,30 1 Laine, dr. M.L. 0,05 0,05 3 Soet, dr. J.J. de 0,25 0,25 1 Soet, dr. J.J. de 0,10 0,10 3

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Position Name fte 2015 plan 2016 funding Shemesh, dr. H. 0,30 0,30 1 Steenbergen, dr. T.J.M. van 0,05 0,05 1 Strijp, dr. A.J.P. van 0,15 0,20 1 Strijp, dr. A.J.P. van 0,05 -- 3 Senior lecturers Veen, dr.ir. M.H. van der 0,50 0,50 1 Wijk, dr. A.J. van 0,40 0,20 1 Wijk, dr. A.J. van 0,30 0,40 3 Zaura, dr. E. 0,40 0,40 1 Zaura, dr. E. 0,40 0,40 3 Aartman, dr. I.H.A. 0,50 0,50 1 Bizzarro, dr. S. 0,40 0,40 1 Bolscher, dr. J.G.M. 0,70 0,70 1 Bonifacio, dr. C.C. 0,30 0,20 1 Brand, dr. H.S. 0,35 0,35 1 Brand, dr. H.S. 0,05 0,05 3 Brandt, dr. B.W. 0,50 0,50 1 Brandt, dr. B.W. 0,30 0,30 3 Dekker, dr. J. den 0,05 -- 1 Other lecturers and tenured Deng, dr. D.M. 0,80 0,80 1 research staff Diermen, dr. D.E. van 0,10 0,10 1 Karagozoglu, drs. K.H. 0,10 0,10 1 Ligtenberg, dr. A.J.M. 0,55 0,55 1 Lindeboom, dr. J.A.H. 0,05 0,05 1 Nicu, dr. E.A. 0,70 0,70 1 Özok, dr. A.R. 0,40 0,40 1 Slot, dr. D.E. 0,70 0,70 3 Vries, dr. T.J. de 0,60 0,60 1 Vries, dr. T.J. de 0,20 0,20 2 Total tenured staff 17,80 17,25 Anssari Moin, drs. D. 0,20 0,20 3 Baaij, drs. A. -- 0,40 1 Bots, dr. C.P. pm pm guest Boutsioukis, dr. C. 0,20 0,20 1 Duijster, dr. D. 0,25 1,00 3 Gambon, dr. D.L. pm pm guest Hesse, dr. D. -- 0,10 1 Laheij, dr. A.M.G.A. -- 0,10 1 Non tenured staff Laheij, dr. A.M.G.A. 0,30 0,40 3 Liu, dds. H. 0,40 0,75 3 Milstein, dr. D.M.J. 0,20 0,20 1 Maskrey, MD. N. pm pm guest Nes, drs. K.A. van -- 0,20 1 Özen, dr. B. 0,50 0,40 1 Raber-Durlacher, dr. J.E. 0,40 0,40 1 Visscher, dr. J.G.A.M. de 0,10 0,10 1 Akveld, MSc. N.A.E. pm pm guest Al Hothali, dds. M.M. pm pm guest Baâdoudi, MSc. F. 0,45 1,00 3 PhD students Bai, dds. X. 0,10 0,75 3 Boink, MSc. M.A. pm pm 2 Bots- van 't Spijker, drs. P.C. pm pm guest

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Position Name fte 2015 plan 2016 funding Broers, drs. D.L.M. pm pm guest Castro Morais Machado, G. de pm pm guest Dekker, drs. H. pm pm 3 Dijk, MSc. I.A., van 0,05 -- 2 Dijk, drs. S., van 0,10 0,10 1 Donders, drs. H.C.M. 0,10 0,10 1 Elkerbout, MSc. T.A. pm pm guest Esposito, dds. S.A. pm pm guest Geurs, MSc. N.C. pm pm guest Gunput, MSc. S.T.G. 0,75 -- 1 Haverman, MSc. T.M. 0,20 0,20 1 Helmers, drs. R. 0,20 0,20 3 Hertog, drs. D. pm pm guest Ho, MSc. J.P.T.F. pm pm guest Hol, drs. M.L.F. pm pm guest Houtem, drs. C.M.H.H. van pm pm 3 Hummel, drs. G.I. pm pm guest Imangaliyev MSc. S. 0,75 0,75 3 Janus, ir. M.M. 0,75 0,75 3 Jong, MSc. B.G. de 0,75 0,75 1 Jong-Lenters, drs. M. de pm pm guest Koopman, drs. J.E. 0,15 -- 1 Koopman, drs. J.E 0,05 -- 3 Kraaij, MSc. S. pm pm guest Krikken, drs. J.B. pm pm 1 PhD students Liao, dds. Y. 0,75 0,75 3 Louropoulou, dds. A. pm pm guest Matse, drs. J.H. pm pm guest May, MSc. A. 0,35 0,35 1 May, MSc. A. 0,40 0,40 3 Mevissen-Renckens, drs. E.H.M. pm pm guest Moghimi, drs. M. pm pm guest Moinzadeh, dds. A.T. pm pm guest Moonen, MSc. C.G.J. -- 0,70 1 Neelakantan, dds. P. pm pm guest Papantonopoulos, dds. G.H. pm pm guest Persoon, MSc. I.F. 0,45 0,45 1 Prodan, MSc. A. 0,75 0,75 3 Rademacher, MSc. W.M.H. 0,20 0,20 1 Raghav, dds. K. pm pm guest Rijkschroeff, MSc. P. 0,75 0,75 1 Roos, drs. C.J.A.M. de pm pm guest Roseboom, drs. H.J. 0,20 0,50 3 Sälzer, dr. S.A. pm pm guest Scheerman, MSc. J.F.M. pm pm guest Schreuder, drs. W.H. 0,10 0,10 3 Shang, MSc. L. 0,15 0,40 3 Sijbrandij, MSc. T. pm pm guest Sluijs, MSc. E. van der pm pm guest Steegman, drs. J. pm pm guest Steenen, drs. S.A. pm pm guest

21 Annual Research Report 2015

Position Name fte 2015 plan 2016 funding Su, dds. N. pm pm guest Sun, dds. W. pm pm guest Tan, drs. C.W.X. pm pm guest Teeuw, MSc. W.J. 0,40 0,40 1 Tuk, drs. J.C. pm pm guest Valstar, drs. M.H. pm pm guest Veerbeek, drs. H.J. pm pm guest Verhulst, MSc. J.M.L. 0,75 0,75 3 Volgenant, drs. C.M.C. 0,45 0,45 2 PhD students Voskuilen, MSc. L. -- 0,75 1 Vliet, drs. N.I. van pm pm guest Vogels, drs. M.P.J.M. pm pm guest Vries, MSc. M.W. de 0,05 0,15 1 Waal, drs. S.V. van der 0,45 0,45 1 Wouden, drs. P. van der 0,25 0,45 1 Zande, MSc. M.M. van der 0,30 0,30 1 Zecha, drs. J.A.E.M. pm pm guest Zemouri, MSc. C. pm pm guest Total non tenured staff 14,15 18,55 total 1st funding 20,00 21,30 1 total 2nd funding 0,70 0,65 2 total 3rd funding 11,25 13,85 3 Total research staff 31,95 35,80

Output

Dissertations Bizzarro, S. (2015, December 04). The clinical, microbiological and systemic characteristics of periodontitis and their changes after periodontal therapy. Universiteit van Amsterdam (233 pag.). Prom./coprom.: prof.dr. B.G. Loos & prof.dr. U. van der Velden. Duijster, D. (2015, February 06). Family Matters. The role of parental and family-related psychosocial factors in childhood dental caries. Universiteit van Amsterdam (219 pag.). Prom./coprom.: prof.dr. C. van Loveren & prof.dr. G.H.W. Verrips. Jansen, I.D.C. (2015, March 09). Functional differences between site-specific osteoclasts. VU University Amsterdam (190 pag.). Prom./coprom.: prof.dr. V. Everts & dr.ir. T.J. de Vries. Rosema, N.A.M. (2015, April 22). Toothbrushing efficacy. Universiteit van Amsterdam (169 pag.). Prom./coprom.: prof.dr. G.A. van der Weijden, prof.dr. W.H. van Palenstein Helderman & prof.dr. U. van der Velden. Slot, D.E. (2015, April 24). Prevention of gingivitis and treatment of periodontitis: Chlorhexidine gels and dental lasers. Universiteit van Amsterdam (290 pag.) ( DIDES). Prom./coprom.: prof.dr. G.A. van der Weijden & prof.dr. U. van der Velden. Theunissen, E.A.R. (2015, June 10). Treatment-induced hearing loss after (chemo)radiotherapy in patients with head and neck cancer. Universiteit van Amsterdam (183 pag.). Prom./coprom.: prof.dr. A.J.M. Balm, prof.dr.ir. W.A. Dreschler, dr. C.L. Zuur & prof.dr. C.R.N. Rasch. Timmermans, A.J. (2015, October 08). Advanced larynx cancer. Trends and treatment outcomes. Universiteit van Amsterdam (233 pag.). Prom./coprom.: prof.dr. M.W.M. van den Brekel & prof.dr. F.J.M. Hilgers. Van der Waal, S.V. (2015, June 24). A new strategy in root canal therapy: there is a lot going on in endodontic disinfection. Universiteit van Amsterdam (159 pag.) (’s-Hertogenbosch: BOXPress). Prom./coprom.: prof.dr. P.R. Wesselink, prof.dr. W. Crielaard & dr. J.J. de Soet.

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Van Monsjou, H. (2015, November 17). Epidemiological characteristics of oral and oropharyngeal squamous cell carcinoma. Universiteit van Amsterdam (207 pag.). Prom./coprom.: prof.dr. A.J.M. Balm, prof.dr. M.W.M. van den Brekel, M. Schaapveld & dr V.B. Wreesmann.

Scientific publications (refereed) Ahdi, M., Teeuw, W.J., Meeuwissen, H.G.T.A., Hoekstra, J.B.L., Gerdes, V.E.A., Loos, B.G. & Meesters, E.W. (2015). Oral health information from the dentist to the diabetologist. European Journal of Internal Medicine, 26 (7), 498-503. doi: 10.1016/j.ejim.2015.06.006 Al-Ansari, S., Zecha, J.A.E.M., Barasch, A., de Lange, J., Rozema, F.R. & Raber-Durlacher, J.E. (2015). Oral mucositis induced by anticancer therapies. Current Oral Health Reports, 2 (4), 202-211. doi: 10.1007/s40496-015-0069-4 Amaliya, A., Laine, M.L., Delanghe, J.R., Loos, B.G., van Wijk, A.J. & van der Velden, U. (2015). Java project on periodontal diseases: periodontal bone loss in relation to environmental and systemic conditions. Journal of Clinical Periodontology, 42 (4), 325-332. doi: 10.1111/jcpe.12381 Amaliya, A., Laine, M.L., Loos, B.G. & van der Velden, U. (2015). Java project on periodontal diseases: effect of vitamin C/calcium threonate/citrus flavonoids supplementation on periodontal pathogens, CRP and HbA1c. Journal of Clinical Periodontology, 42 (12), 1097-1104. doi: 10.1111/jcpe.12478 Andrault, P.M., Samsonov, S.A., Weber, G., Coquet, L., Nazmi, K., Bolscher, J.G.M., Lalmanach, A.C., Jouenne, T., Brömme, D., Pisabarro, M.T., Lalmanach, G. & Lecaille, F. (2015). Antimicrobial peptide LL-37 is both a substrate of Cathepsins S and K and a selective inhibitor of Cathepsin L. Biochemistry, 54 (17), 2785-2798. doi: 10.1021/acs.biochem.5b00231 Angwaravong, O., Pitiphat, W., Bolscher, J.G.M. & Chaiyarit, P. (2015). Evaluation of salivary mucins in children with deciduous and mixed dentition: comparative analysis between high and low caries-risk groups. Clinical Oral Investigations, 19 (8), 1931-1937. doi: 10.1007/s00784-015-1428-1 Armfield, J.M. & Ketting, M. (2015). Predictors of dental avoidance among Australian adults with different levels of dental anxiety. Health Psychology, 34 (9), 929-940. doi: 10.1037/hea0000186 Aznar Portoles, C., Moinzadeh, A.T. & Shemesh, H. (2015). A central incisor with 4 independent root canals: a case report. The Journal of Endodontics, 41 (11), 1903-1906. doi: 10.1016/j.joen.2015.08.001 Bao, X., de Soet, J.J., Tong, H., Gao, X., He, L., van Loveren, C. & Deng, D.M. (2015). Streptococcus oligofermentans inhibits Streptococcus mutans in biofilms at both neutral pH and cariogenic conditions. PLoS One, 10 (6):e0130962. doi: 10.1371/journal.pone.0130962 Barrera, M.J., Aguilera, S., Veerman, E., Quest, A.F.G., Díaz-Jiménez, D., Urzúa, U., Cortés, J., González, S., Castro, I., Molina, C., Bahamondes, V., Leyton, C., Hermoso, M.A. & González, M.J. (2015). Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren's syndrome? Rheumatology, 54 (8), 1518-1527. doi: 10.1093/rheumatology/kev026 Beerens, M.W., Boekitwetan, F., van der Veen, M.H. & ten Cate, J.M. (2015). White spot lesions after orthodontic treatment assessed by clinical photographs and by quantitative light-induced fluorescence imaging; a retrospective study. Acta Odontologica Scandinavica, 73 (6), 441-446. doi: 10.3109/00016357.2014.980846 Berti, G.O., Hesse, D., Bonifácio, C.C., Raggio, D.P. & Bonecker, M. (2015). Epidemiological study of traumatic dental injuries in 5- to 6-year‑old Brazilian children. Brazilian Oral Research, 29 (1), 1-6. doi: 10.1590/1807- 3107BOR-2015.vol29.0103 Bicanic, I.A.E., Hehenkamp, L.M., van de Putte, E.M., van Wijk, A.J. & de Jongh, A. (2015). Predictors of delayed disclosure of rape in female adolescents and young adults. European Journal of Psychotraumatology, 6, 25883. doi: 10.3402/ejpt.v6.25883 Brand, H.S., van der Cammen, C.C.J., Roorda, S.M.E. & Baart, J.A. (2015). Tooth extraction education at dental schools across Europe. British Dental Journal, 1:15002. doi: 10.1038/bdjopen.2015.2 Buch, F., Kaman, W.E., Bikker, F.J., Yilamujiang, A. & Mithöfer, A. (2015). Nepenthesin protease activity indicates digestive fluid dynamics in carnivorous Nepenthes plants. PLoS One, 10 (3):e0118853. doi: 10.1371/journal.pone.0118853 Carvalho, J.C., Mestrinho, H.D., Stevens, S. & van Wijk, A.J. (2015). Do oral health conditions adversely impact young adults? Caries Research, 49 (3), 266-274. doi: 10.1159/000375377 Chan, A., Cameron, M.C., Garden, B., Boers-Doets, C.B., Schindler, K., Epstein, J.B., Choi, J., Beamer, L., Roeland, E., Russi, E.G., Bensadoun, R.J., Teo, Y.L., Chan, R.J., Shih, V., Bryce, J., Raber-Durlacher, J., Gerber,

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P.A., Freytes, C.O., Rapoport, B., LeBoeuf, N., Sibaud, V. & Lacouture, M.E. (2015). A systematic review of patient-reported outcome instruments of dermatologic adverse events associated with targeted cancer therapies. Supportive Care in Cancer, 23 (8), 2231-2244. doi: 10.1007/s00520-014-2564-x Chapple, I.L.C., van der Weijden, F., Doerfer, C., Herrera, D., Shapira, L., Polak, D., Madianos, P., Louropoulou, A., Machtei, E., Donos, N., Greenwell, H., van Winkelhoff, A.J., Eren Kuru, B., Arweiler, N., Teughels, W., Aimetti, M., Molina, A., Montero, E. & Graziani, F. (2015). Primary prevention of periodontitis: managing gingivitis. Journal of Clinical Periodontology, 42 (S16), S71-S76. doi: 10.1111/jcpe.12366 Cioccari Oliveira, S., Slot, D.E., Celeste, R.K., Abegg, C., Keijser, B.J.F. & van der Weijden, F.A. (2015). Correlations between two different methods to score bleeding and the relationship with plaque in systemically healthy young adults. Journal of Clinical Periodontology, 42 (10), 908-913. doi: 10.1111/jcpe.12435 Clarkson, B.H. & Exterkate, R.A.M. (2015). Noninvasive dentistry: a dream or reality? Caries Research, 49 (Suppl 1), 11-17. doi: 10.1159/000380887 Cohenca, N. & Shemesh, H. (2015). Clinical applications of cone beam computed tomography in endodontics: a comprehensive review. Part 1: applications associated with endodontic treatment and diagnosis. Quintessence International, 46 (6), 465-480. doi: 10.3290/j.qi.a33990 Cohenca, N. & Shemesh, H. (2015). Clinical applications of cone beam computed tomography in endodontics: a comprehensive review. Part 2: applications associated with advanced endodontic problems and complications. Quintessence International, 46 (8), 657-668. doi: 10.3290/j.qi.a34396 Coorens, M., van Dijk, A., Bikker, F., Veldhuizen, E.J.A. & Haagsman, H.P. (2015). Importance of endosomal cathelicidin degradation to enhance DNA-induced chicken macrophage activation. The Journal of Immunology, 195 (8), 3970-3977. doi: 10.4049/jimmunol.1501242 Cukkemane, N., Bikker, F.J., Nazmi, K., Brand, H.S., Sotres, J., Lindh, L., Arnebrant, T. & Veerman, E.C.I. (2015). Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans. European Journal of Oral Sciences, 123 (4), 221-227. doi: 10.1111/eos.12200 Damaskos, S., Aartman, I.H.A., Tsiklakis, K., van der Stelt, P. & Berkhout, W.E.R. (2015). Association between extra- and intracranial calcifications of the internal carotid artery: a CBCT imaging study. Dentomaxillofacial Radiology, 44 (5):20140432. doi: 10.1259/dmfr.20140432 De Boer, I.R., Lagerweij, M.D., Wesselink, P.R. & Vervoorn, J.M. (2015). Evaluation of the appreciation of virtual teeth with and without pathology. European Journal of Dental Education, 19 (2), 87-94. doi: 10.1111/eje.12108 De Bont, P.A.J.M., van den Berg, D.P.G., van der Vleugel, B.M., de Roos, C., de Jongh, A., van der Gaag, M. & van Minnen, A. (2015). Predictive validity of the Trauma Screening Questionnaire in detecting posttraumatic stress disorder in patients with psychotic disorders. British Journal of Psychiatry, 206 (5), 408- 416. doi: 10.1192/bjp.bp.114.148486 De Jong, M.C., ten Hoeve, J.J., Grénman, R., Wessels, L.F., Kerkhoven, R., te Riele, H., van den Brekel, M.W.M., Verheij, M. & Begg, A.C. (2015). Pretreatment microRNA Expression Impacting on Epithelial-to- Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients. Clinical Cancer Research, 21 (4), 5630-5638. doi: 10.1158/1078-0432.CCR-15-0454 De Jong-Lenters, M., van Dommelen, P., Schuller, A.A. & Verrips, E.H.W. (2015). Body mass index and dental caries in children aged 5 to 8 years attending a dental paediatric referral practice in the Netherlands. BMC Research Notes, 8:738. doi: 10.1186/s13104-015-1715-6 De Vries, T.J., Schoenmaker, T., Aerts, D., Grevers, L.C., Souza, P.P.C., Nazmi, K., van de Wiel, M.A., Ylstra, B., van Lent, P.L., Leenen, P.J.M. & Everts, V. (2015). M-CSF priming of osteoclast precursors can cause osteoclastogenesis-insensitivity, which can be prevented and overcome on bone. Journal of Cellular Physiology, 230 (1), 210-225. doi: 10.1002/jcp.24702 Den Toom, I.J., Heuveling, D.A., Flach, G.B., van Weert, S., Karagozoglu, K.H., van Schie, A., Bloemena, E., Leemans, C.R. & de Bree, R. (2015). Sentinel node biopsy for early-stage oral cavity cancer: the VU University Medical Center experience. Head & Neck, 37 (4), 573-578. doi: 10.1002/hed.23632 Dirkes, M.C., Milstein, D.M.J., Heger, M. & van Gulik, T.M. (2015). Absence of hydrogen sulfide-induced hypometabolism in pigs: A mechanistic explanation in relation to small nonhibernating mammals. European Surgical Research, 54 (3-4), 178-191. doi: 10.1159/000369795 Duijster, D., de Jong-Lenters, M., de Ruiter, C., Thijssen, J., van Loveren, C. & Verrips, E. (2015). Parental and family-related influences on dental caries in children of Dutch, Moroccan and Turkish origin. Community Dentistry and Oral Epidemiology, 43 (2), 152-162. doi: 10.1111/cdoe.12134

24 Academic Centre for Dentistry Amsterdam

Duijster, D., de Jong-Lenters, M., Verrips, E. & van Loveren, C. (2015). Establishing oral health promoting behaviours in children: parents' views on barriers, facilitators and professional support: a qualitative study. BMC Oral Health, 15:157. doi: 10.1186/s12903-015-0145-0 Elad, S., Jensen, S.B., Raber-Durlacher, J.E., Mouradian, N., Correa, E.M.P., Schubert, M.M., Blijlevens, N.M.A., Epstein, J.B., Saunders, D.P., Waltimo, T., Yarom, N., Zadik, Y. & Brennan, M.T. (2015). Clinical approach in the management of oral chronic graft-versus-host disease (cGVHD) in a series of specialized medical centers. Supportive Care in Cancer, 23 (6), 1615-1622. doi: 10.1007/s00520-014-2503-x Elad, S., Raber-Durlacher, J.E., Brennan, M.T., Saunders, D.P., Mank, A.P., Zadik, Y., Quinn, B., Epstein, J.B., Blijlevens, N.M.A., Waltimo, T., Passweg, J.R., Correa, M.E.P., Dahllöf, G., Garming-Legert, K.U.E., Logan, R.M., Potting, C.M.J., Shapira, M.Y., Soga, Y., Stringer, J., Stokman, M.A., Vokurka, S., Wallhult, E., Yarom, N. & Jensen, S.B. (2015). Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Supportive Care in Cancer, 23 (1), 223-236. doi: 10.1007/s00520-014-2378-x Everaars, B., Jerkovic-Cosic, K., van der Putten, G.J. & van der Heijden, G.J.M.G. (2015). Probing problems and priorities in oral health (care) among community dwelling elderly in the Netherlands - A mixed method study. International Journal of Health Sciences and Research, 5 (9), 415-429. Exterkate, R.A.M., Zaura, E., Brandt, B.W., Buijs, M.J., Koopman, J.E., Crielaard, W. & ten Cate, J.M. (2015). The effect of propidium monoazide treatment on the measured bacterial composition of clinical samples after the use of a mouthwash. Clinical Oral Investigations, 19 (4), 813-822. doi: 10.1007/s00784-014-1297-z Frantsve-Hawley, J., Clarkson, J.E. & Slot, D.E. (2015). Using the best evidence to enhance dental hygiene decision making. Journal of Dental Hygiene, 89 (suppl 1), 39-42. Gómez-Molero, E., de Boer, A.D., Dekker, H.L., Moreno-Martínez, A., Kraneveld, E.A., Ichsan, Chauhan, N., Weig, M., de Soet, J.J., de Koster, C.G., Bader, O. & de Groot, P.W.J. (2015). Proteomic analysis of hyperadhesive Candida glabrata clinical isolates reveals a core wall proteome and differential incorporation of adhesins. FEMS Yeast Research, 15 (8):fov098. doi: 10.1093/femsyr/fov098 Groothuis-Oudshoorn, C.G.M., Chorus, A.M.J., Verrips, G.H.W. & Detmar, S.B. (2015). Development and validation of the Dutch version of the London Handicap Scale. Journal of Back and Musculoskeletal Rehabilitation, 28 (2), 401-408. doi: 10.3233/BMR-140534 Gunput, S.T.G., Ligtenberg, A.J.M., Terlouw, B., Brouwer, M., Veerman, E.C.I. & Wouters, D. (2015). Complement activation by salivary agglutinin is secretor status dependent. Biological Chemistry, 396 (1), 35-43. doi: 10.1515/hsz-2014-0200 He, L., Deng, D., Zhou, X., Cheng, L., ten Cate, J.M., Li, J., Li, X. & Crielaard, W. (2015). Novel tea polyphenol- modified calcium phosphate nanoparticle and its remineralization potential. Journal of Biomedical Materials Research. Part B Applied Biomaterials, 103 (8), 1525-1531. doi: 10.1002/jbm.b.33333 Hesse, D., Bonifácio, C.C., Guglielmi, C. de Almeida Brandao, da Franca, C., Mendes, F.M. & Raggio, D.P. (2015). Low-cost glass ionomer cement as ART sealant in permanent molars: a randomized clinical trial. Brazilian Oral Research, 29 (1). doi: 10.1590/1807-3107BOR-2015.vol29.0063 Heuveling, D.A., van Weert, S., Karagozoglu, K.H. & de Bree, R. (2015). Evaluation of the use of freehand SPECT for sentinel node biopsy in early stage oral carcinoma. Oral Oncology, 51 (3), 287-290. doi: 10.1016/j.oraloncology.2014.12.001 Hilgers, F.J.M., Dirven, R., Jacobi, I. & van den Brekel, M.W.M. (2015). Physiology and prospects of bimanual tracheoesophageal brass instrument play. Acta Otorhinolaryngologica Italica, 35 (3), 202-207. Hoogenkamp, M.A., Crielaard, W. & Krom, B.P. (2015). Uses and limitations of green fluorescent protein as a viability marker in Enterococcus faecalis: an observational investigation. Journal of Microbiological Methods, 115, 57-63. doi: 10.1016/j.mimet.2015.05.020 Imangaliyev, S., Keijser, B., Crielaard, W. & Tsivtsivadze, E. (2015). Personalized microbial network inference via co-regularized spectral clustering. Methods, 83, 28-35. doi: 10.1016/j.ymeth.2015.03.017 Janus, M.M., Keijser, B.J.F., Bikker, F.J., Exterkate, R.A.M., Crielaard, W. & Krom, B.P. (2015). In vitro phenotypic differentiation towards commensal and pathogenic oral biofilms. Biofouling, 31 (6), 503-510. doi: 10.1016/j.ymeth.2015.03.017 Kaper, N.M., Swennen, M.H.J., van Wijk, A.J., Kalkman, C.J., van Rheenen, N., van der Graaf, Y. & van der Heijden, G.J.M.G. (2015). The "evidence-based practice inventory": reliability and validity was demonstrated for a novel instrument to identify barriers and facilitators for Evidence Based Practice in health care. Journal of Clinical Epidemiology, 68 (11), 1261-1269. doi: 10.1016/j.jclinepi.2015.06.002

25 Annual Research Report 2015

Karssemakers, L.H.E., Forouzanfar, T., Schulten, E.A.J.M. & Karagozoglu, K.H. (2015). Bilateral conjunctival swelling after dental extraction. Lancet Infectious Diseases, 15 (6), 746. doi: 10.1016/S1473- 3099(15)00031-6 Khandan, A., Karamian, E., Mehdikhani-Nahrkhalaji, M., Mirmohammadi, H., Farzadi, A., Ozada, N., Heidarshenas, B. & Zamani, K. (2015). Influence of spark plasma sintering and baghdadite powder on mechanical properties of hydroxyapatite. Procedia Materials Science, 11, 183-189. doi: 10.1016/j.mspro.2015.11.087 Koop, G., van Werven, T., Roffel, S., Hogeveen, H., Nazmi, K. & Bikker, F.J. (2015). Short communication: protease activity measurement in milk as a diagnostic test for clinical mastitis in dairy cows. Journal of Dairy Science, 98 (7), 4613-4618. doi: 10.3168/jds.2014-8746 Koopman, J.E., van der Kaaij, N.C.W., Buijs, M.J., Elyassi, Y., van der Veen, M.H., Crielaard, W., ten Cate, J.M. & Zaura, E. (2015). The effect of fixed orthodontic appliances and fluoride mouthwash on the oral microbiome of adolescents: a randomized controlled clinical trial. PLoS One, 10 (9):e0137318. doi: 10.1371/journal.pone.0137318 Kraaij, S., Karagozoglu, K.H., Kenter, Y.A.G., Pijpe, J., Gilijamse, M. & Brand, H.S. (2015). Systemic diseases and the risk of developing salivary stones: a case control study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 119 (5), 539-543. doi: 10.1016/j.oooo.2015.01.010 Kraaijenga, S.A.C., Oskam, I.M., van der Molen, L., Hamming-Vrieze, O., Hilgers, F.J.M. & van den Brekel, M.W.M. (2015). Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral Oncology, 51 (8), 787-794. doi: 10.1016/j.oraloncology.2015.05.003 Kraaijenga, S.A.C., van der Molen, L., Jacobi, I., Hamming-Vrieze, O., Hilgers, F.J.M. & van den Brekel, M.W.M. (2015). Prospective clinical study on long term swallowing function and voice quality in advanced head and neck cancer patients treated with concurrent chemoradiotherapy and preventive swallowing exercises. European Archives of Oto-Rhino-Laryngology, 272 (11), 3521-3531. doi: 10.1007/s00405-014-3379-6 Kraaijenga, S.A.C., van der Molen, L., Stuiver, M.M., Teertstra, H.J., Hilgers, F.J.M. & van den Brekel, M.W.M. (2015). Effects of strengthening exercises on swallowing musculature and function in senior healthy subjects: a prospective effectiveness and feasibility study. Dysphagia, 30 (4), 392-403. doi: 10.1007/s00455- 015-9611-8 Krikken, J.B., de Jongh, A., Veerkamp, J.S.J., Vogels, W., ten Cate, J.M. & van Wijk, A.J. (2015). Longitudinal changes in dental fear and coping behavior in children, adolescents, and young adults with cleft lip and/or cleft palate. Cleft Palate-Craniofacial Journal, 52 (4), e73-e80. doi: 10.1597/12-262 Kuper, N.K., van de Sande, F.H., Opdam, N.J.M., Bronkhorst, E.M., de Soet, J.J., Cenci, M.S. & Huysmans, M.C.D.N.J.M. (2015). Restoration materials and secondary caries using an in vitro biofilm model. Journal of Dental Research, 94 (1), 62-68. doi: 10.1177/0022034514553245 Lagerweij, M.D. & van Loveren, C. (2015). Declining caries trends: are we satisfied? Current Oral Health Reports, 2 (4), 212-217. doi: 10.1007/s40496-015-0064-9 Laheij, A.M.G.A., Rasch, C.N., Brandt, B.W., de Soet, J.J., Schipper, R.G., Loof, A., Silletti, E. & van Loveren, C. (2015). Proteins and peptides in parotid saliva of irradiated patients compared to that of healthy controls using SELDI-TOF-MS. BMC Research Notes, 8:639. doi: 10.1186/s13104-015-1641-7 Laheij, A.M.G.A., van Loveren, C., Deng, D. & de Soet, J.J. (2015). The impact of virulence factors of Porphyromonas gingivalis on wound healing in vitro. Journal of Oral Microbiology, 7:27543. doi: 10.3402/jom.v7.27543 Liao, Y., Chen, J., Brandt, B.W., Zhu, Y., Li, J., van Loveren, C. & Deng, D.M. (2015). Identification and functional analysis of genome mutations in a fluoride-resistant Streptococcus mutans strain. PLoS One, 10 (4):e0122630. doi: 10.1371/journal.pone.0122630 Ligtenberg, A.J.M., Brand, H.S., van den Keijbus, P.A.M. & Veerman, E.C.I. (2015). The effect of physical exercise on salivary secretion of MUC5B, amylase and lysozyme. Archives of Oral Biology, 60 (11), 1639- 1644. doi: 10.1016/j.archoralbio.2015.07.012 Lindeboom, J.A. (2015). Pediatric cervicofacial lymphadenitis caused by Bartonella henselae. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 120 (4), 469-473. doi: 10.1016/j.oooo.2015.06.031 Lodder, W.L., Vogel, W.V., Lange, C.A., Hamming-Vrieze, O., van Velthuysen, M.L., Pameijer, F.A., Balm, A.J. & van den Brekel, M.W. (2015). Detection of extranodal spread in head and neck cancer with [18F]FDG PET and MRI: improved accuracy? The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 59, 327- 335. Lodders, J.N., Parmar, S., Stienen, N.L.M., Martin, T.J., Karagozoglu, K.H., Heymans, M.W., Nandra, B. & Forouzanfar, T. (2015). Incidence and types of complications after ablative oral cancer surgery with primary

26 Academic Centre for Dentistry Amsterdam

microvascular free flap reconstruction. Medicina Oral Patologia Oral y Cirurgia Bucal, 20 (6), e744-e750. doi: 10.4317/medoral.20657 Lodders, J.N., Parmar, S., Stienen, N.L.M., Martin, T.J., Karagozoglu, K.H., Heymans, M.W. & Forouzanfar, T. (2015). Incidence of symptomatic venous thromboembolism in oncological oral and maxillofacial operations: retrospective analysis. British Journal of Oral & Maxillofacial Surgery, 53 (3), 244-250. doi: 10.1016/j.bjoms.2014.12.001 Louropoulou, A., Slot, D.E. & van der Weijden, F. (2015). Influence of mechanical instruments on the biocompatibility of titanium dental implants surfaces: a systematic review. Clinical Oral Implants Research, 26 (7), 841-850. doi: 10.1111/clr.12365 Marques, M.S., Wesselink, P.R. & Shemesh, H. (2015). Outcome of direct pulp capping with mineral trioxide aggregate: a prospective study. The Journal of Endodontics, 41 (7), 1026-10231. doi: 10.1016/j.joen.2015.02.024 Matse, J.H., Yoshizawa, J., Wang, X., Elashoff, D., Bolscher, J.G.M., Veerman, E.C.I., Leemans, C.R., Pegtel, M.D., Wong, D.T.W. & Bloemena, E. (2015). Human salivary micro-RNA in patients with parotid salivary gland neoplasms. PLoS One, 10 (11):e0142264. doi: 10.1371/journal.pone.0142264 May, A., Abeln, S., Buijs, M.J., Heringa, J., Crielaard, W. & Brandt, B.W. (2015). NGS-eval: NGS Error analysis and novel sequence VAriant detection tooL. Nucleic Acids Research, 43 (W1), W301-W305. doi: 10.1093/nar/gkv346 Mirabile, A., Numico, G., Russi, E.G., Bossi, P., Crippa, F., Bacigalupo, A., de Sanctis, V., Musso, S., Merlotti, A., Ghi, M.G., Merlano, M.C., Licitra, L., Moretto, F., Denaro, N., Caspiani, O., Buglione, M., Pergolizzi, S., Cascio, A., Bernier, J., Raber-Durlacher, J., Vermorken, J.B., Murphy, B., Ranieri, M.V. & Dellinger, R.P. (2015). Sepsis in head and neck cancer patients treated with chemotherapy and radiation: literature review and consensus. Critical Reviews in Oncology/Hematology, 95 (2), 191-213. doi: 10.1016/j.critrevonc.2015.03.003 Mirmohammadi, H., Mahdi, L., Partovi, P., Khademi, A., Shemesh, H. & Hassan, B. (2015). Accuracy of conebeam computed tomography in the detection of a second mesiobuccal root canal in endodontically treated teeth: an ex vivo study. The Journal of Endodontics, 41 (10), 1678-1681. doi: 10.1016/j.joen.2015.06.011 Moinzadeh, A.T., Jongsma, L.A. & Wesselink, P.R. (2015). Considerations about the use of the "push-out" test in Endodontic research. International Endodontic Journal, 48 (5), 498-500. doi: 10.1111/iej.12416 Moinzadeh, A.T., Mirmohammadi, H., Hensbergen, I.A.M., Wesselink, P.R. & Shemesh, H. (2015). The correlation between fluid transport and push-out strength in root canals filled with a methacrylate-based filling material. International Endodontic Journal, 48 (2), 193-198. doi: 10.1111/iej.12300 Moinzadeh, A.T., Zerbst, W., Boutsioukis, C., Shemesh, H. & Zaslansky, P. (2015). Porosity distribution in root canals filled with gutta percha and calcium silicate cement. Dental Materials, 31 (9), 1100-1108. doi: 10.1016/j.dental.2015.06.009 Nagy, T., van Lien, R., Willemsen, G., Proctor, G., Effting, M., Fülöp, M., Bárdos, G., Veerman, E.C.I. & Bosch, J.A. (2015). A fluid response: alpha-amylase reactions to acute laboratory stress are related to sample timing and saliva flow rate. Biological Psychology, 109, 111-119. doi: 10.1016/j.biopsycho.2015.04.012 Neelakantan, P., Nandagopal, M., Shemesh, H. & Wesselink, P.R. (2015). The effect of root dentin conditioning protocols on the push-out bond strength of three calcium silicate sealers. International Journal of Adhesion and Adhesives, 60, 104-108. doi: 10.1016/j.ijadhadh.2015.04.006 Neelakantan, P., Sharma, S., Shemesh, H. & Wesselink, P.R. (2015). Influence of irrigation sequence on the adhesion of root canal sealers to dentin: a fourier transform infrared spectroscopy and push-out bond strength analysis. The Journal of Endodontics, 41 (7), 1108-1111. doi: 10.1016/j.joen.2015.02.001 O'Donnell, L.E., Robertson, D., Nile, C.J., Cross, L.J., Riggio, M., Sherriff, A., Bradshaw, D., Lambert, M., Malcolm, J., Buijs, M.J., Zaura, E., Crielaard, W., Brandt, B.W. & Ramage, G. (2015). The oral microbiome of denture wearers is influenced by levels of natural dentition. PLoS One, 10 (9):e0137717. doi: 10.1371/journal.pone.0137717 Papantonopoulos, G., Gogos, C., Housos, E., Bountis, T. & Loos, B.G. (2015). Peri-implantitis: a complex condition with non-linear characteristics. Journal of Clinical Periodontology, 42 (8), 789-798. doi: 10.1111/jcpe.12430 Patel, S., Durack, C., Abella, F., Shemesh, H., Roig, M. & Lemberg, K. (2015). Cone beam computed tomography in Endodontics - a review. International Endodontic Journal, 48 (1), 3-15. doi: 10.1111/iej.12270 Petti, S., Kakisina, N., Volgenant, C.M.C., Messano, G.A., Barbato, E., Passariello, C. & de Soet, J.J. (2015). Low methicillin-resistant Staphylococcus aureus carriage rate among Italian dental students. American Journal of Infection Control, 43 (12), e89-e91. doi: 10.1016/j.ajic.2015.08.008

27 Annual Research Report 2015

Prodan, A., Brand, H.S., Ligtenberg, A.J.M., Imangaliyev, S., Tsivtsivadze, E., van der Weijden, F., Crielaard, W., Keijser, B.J.F. & Veerman, E.C.I. (2015). Interindividual variation, correlations, and sex-related differences in the salivary biochemistry of young healthy adults. European Journal of Oral Sciences, 123 (3), 149-157. doi: 10.1111/eos.12182 Rashid, M.U., Zaura, E., Buijs, M.J., Keijser, B.J.F., Crielaard, W., Nord, C.E. & Weintraub, A. (2015). Determining the long-term effect of antibiotic administration on the human normal intestinal microbiota using culture and pyrosequencing methods. Clinical Infectious Diseases, 60 (Suppl 2), S77-S84. doi: 10.1159/000380870 Retèl, V.P., van den Boer, C., Steuten, L.M.G., Okła, S., Hilgers, F.J. & van den Brekel, M.W. (2015). Cost- effectiveness of heat and moisture exchangers compared to usual care for pulmonary rehabilitation after total laryngectomy in Poland. European Archives of Oto-Rhino-Laryngology, 272 (9), 2381-2388. doi: 10.2319/062414-453.1 Rietbergen, M.M., Witte, B.I., Velazquez, E.R., Snijders, P.J.F., Bloemena, E., Speel, E.J., Brakenhoff, R.H., Kremer, B., Lambin, P. & Leemans, C.R. (2015). Different prognostic models for different patient populations: validation of a new prognostic model for patients with oropharyngeal cancer in Western Europe. The British Journal of Cancer, 112 (11), 1733-1736. doi: 10.1038/bjc.2015.139 Ruslin, M., Wolff, J., Boffano, P., Brand, H.S. & Forouzanfar, T. (2015). Dental trauma in association with maxillofacial fractures: an epidemiological study. Dental Traumatology, 31 (4), 318-323. doi: 10.1111/edt.12176 Sälzer, S., Slot, D.E., Dörfer, C.E. & van der Weijden, G.A. (2015). Comparison of triclosan and stannous fluoride dentifrices on parameters of gingival inflammation and plaque scores: a systematic review and meta-analysis. International Journal of Dental Hygiene, 13 (1), 1-17. doi: 10.1111/idh.12072 Sälzer, S., Slot, D.E., van der Weijden, F.A. & Dörfer, C.E. (2015). Efficacy of inter-dental mechanical plaque control in managing gingivitis - a meta-review. Journal of Clinical Periodontology, 42 (S16), S92-S105. doi: 10.1111/jcpe.12363 Samimi, P., Hasankhani, A., Matinlinna, J.P. & Mirmohammadi, H. (2015). Effect of adhesive resin type for bonding to zirconia using two surface pretreatments. Journal of Adhesive Dentistry, 17 (4), 353-359. doi: 10.3290/j.jad.a34593 Sanz, M., Bäumer, A., Buduneli, N., Dommisch, H., Farina, R., Kononen, E., Linden, G., Meyle, J., Preshaw, P.M., Quirynen, M., Roldan, S., Sanchez, N., Sculean, A., Slot, D.E., Trombelli, L., West, N. & Winkel, E. (2015). Effect of professional mechanical plaque removal on secondary prevention of periodontitis and the complications of gingival and periodontal preventive measures: consensus report of group 4 of the 11th European Workshop on Periodontology on effective prevention of periodontal and peri-implant diseases. Journal of Clinical Periodontology, 42 (S16), S214-S220. doi: 10.1111/jcpe.12367 Schaefer, A.S., Bochenek, G., Jochens, A., Ellinghaus, D., Dommisch, H., Güzeldemir-Akçakanat, E., Graetz, C., Harks, I., Jockel-Schneider, Y., Weinspach, K., Meyle, J., Eickholz, P., Linden, G.J., Cine, N., Nohutcu, R., Weiss, E., Houri-Haddad, Y., Iraqi, F., Folwaczny, M., Noack, B., Strauch, K., Gieger, C., Waldenberger, M., Peters, A., Wijmenga, C., Yilmaz, E., Lieb, W., Rosenstiel, P., Doerfer, C., Bruckmann, C., Erdmann, J., König, I., Jepsen, S., Loos, B.G. & Schreiber, S. (2015). Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Circulation. Cardiovascular Genetics, 8 (1), 159-167. doi: 10.1161/CIRCGENETICS.114.000554 Scheres, N., Lamont, R.J., Crielaard, W. & Krom, B.P. (2015). LuxS signaling in Porphyromonas gingivalis-host interactions. Anaerobe, 35 (Part A), 3-9. doi: 10.1016/j.anaerobe.2014.11.011 Schilling, C., Stoeckli, S.J., Haerle, S.K., Broglie, M.A., Huber, G.F., Sorensen, J.A., Bakholdt, V., Kroghdal, A., Von Buchwald, C., Bilde, A., Sebbesen, L.R., Odell, E., Gurney, B., O'Doherty, M., de Bree, R., Bloemena, E., Flach, G.B., Villareal, P.M., Fresno Forcelledo, M.F., Junquera Gutierrez, L.M., Amézaga, J.A., Barbier, L., Santamaría-Zuazua, J., Moreira, A., Jacome, M., Vigili, M.G., Rahimi, S., Tartaglione, G., Lawson, G., Nollevaux, M.C., Grandi, C., Donner, D., Bragantini, E., Dequanter, D., Lothaire, P., Poli, T., Silini, E.M., Sesenna, E., Dolivet, G., Mastronicola, R., Leroux, A., Sassoon, I., Sloan, P. & McGurk, M. (2015). Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer. European Journal of Cancer, 51 (18), 2777-2784. doi: 10.1016/j.ejca.2015.08.023 Schlecht, L.M., Peters, B.M., Krom, B.P., Freiberg, J.A., Hänsch, G.M., Filler, S.G., Jabra-Rizk, M.A. & Shirtliff, M.E. (2015). Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue. Microbiology - SGM, 161, 168-181. doi: 10.1099/mic.0.083485-0 Schoot, R.A., Slater, O., Ronckers, C.M., Zwinderman, A.H., Balm, A.J.M., Hartley, B., van den Brekel, M.W., Gupta, S., Saeed, P., Gajdosova, E., Pieters, B.R., Gaze, M.N., Mandeville, H.C., Fajardo, R.D., Chang, Y.C., Gains, J.E., Strackee, S.D., Dunaway, D., Abela, C., Mason, C., Smeele, L.E., Chisholm, J.C., Levitt, G.A.,

28 Academic Centre for Dentistry Amsterdam

Kremer, L.C.M., Grootenhuis, M.A., Maurice-Stam, H., Stiller, C.A., Hammond, P., Caron, H.N. & Merks, J.H.M. (2015). Adverse events of local treatment in long term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. European Journal of Cancer, 51 (11), 1424-1434. doi: 10.1016/j.ejca.2015.02.010 Schouten, C.S., de Graaf, P., Alberts, F.M., Hoekstra, O.S., Comans, E.F.I., Bloemena, E., Witte, B.I., Sanchez, E., Leemans, C.R., Castelijns, J.A. & de Bree, R. (2015). Response evaluation after chemoradiotherapy for advanced nodal disease in head and neck cancer using diffusion-weighted MRI and 18F-FDG-PET-CT. Oral Oncology, 51 (5), 541-547. doi: 10.1016/j.oraloncology.2015.01.017 Schouten, C.S., de Graaf, P., Bloemena, E., Witte, B.I., Braakhuis, B.J.M., Brakenhoff, R.H., Leemans, C.R., Castelijns, J.A. & de Bree, R. (2015). Quantitative diffusion-weighted MRI parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma. American Journal of Neuroradiology, 36 (4), 763-767. doi: 10.3174/ajnr.A4271 Shemesh, H. (2015). Endodontic instrumentation and root filling procedures: effect on mechanical integrity of dentin. Endodontic Topics, 33 (1), 43-49. doi: 10.1111/etp.12084 Slot, D.E., van der Geest, S., van der Weijden, F.A. & Quirynen, M. (2015). Treatment of oral malodour. Medium-term efficacy of mechanical and/or chemical agents: a systematic review. Journal of Clinical Periodontology, 42 (SI6), S303-S316. doi: 10.1111/jcpe.12378 Sokos, D., Everts, V. & de Vries, T.J. (2015). Role of periodontal ligament fibroblasts in osteoclastogenesis: a review. Journal of Periodontal Research, 50 (2), 152-159. doi: 10.1111/jre.12197 Steenen, S.A., van Wijk, A.J., van der Heijden, G.J.M.G., van Westrhenen, R., de Lange, J. & de Jongh, A. (2015). Propranolol for treatment of anxiety disorders: Systematic review and meta-analysis. Journal of Psychopharmacology, 30 (2), 128-139. doi: 10.1177/0269881115612236 Steenen, S.A., van Wijk, A.J., van Westrhenen, R., de Lange, J. & de Jongh, A. (2015). Effects of propranolol on fear of dental extraction: study protocol for a randomized controlled trial. Trials, 16 (136). doi: 10.1186/s13063-015-1065-7 Stoker, S.D., Indrasari, S.R., Herdini, C., Hariwiyanto, B., Karrakullukcu, B., Dhamiyati, W., Widayati, K., Rhomdoni, A., Fles, R., Haryana, S.M., Wildeman, M.A.M. & Tan, I.B. (2015). Photodynamic therapy as salvage therapy for patients with nasopharyngeal carcinoma experiencing local failures following definitive radiotherapy. Photodiagnosis and Photodynamic Therapy, 12 (3), 519-525. doi: 10.1016/j.pdpdt.2015.04.005 Stoker, S.D., Novalić, Z., Wildeman, M.A., Huitema, A.D.R., Verkuijlen, S.A.W.M., Juwana, H., Greijer, A.E., Tan, I.B., Middeldorp, J.M. & de Boer, J.P. (2015). Epstein Barr virus targeted therapy in nasopharyngeal carcinoma. Journal of Cancer Research and Clinical Oncology, 141 (10), 1845-1857. doi: 10.1007/s00432- 015-1969-3 Supranoto, S.C., Slot, D.E., Addy, M. & van der Weijden, G.A. (2015). The effect of chlorhexidine dentifrice or gel versus chlorhexidine mouthwash on plaque, gingivitis, bleeding and tooth discoloration: a systematic review. International Journal of Dental Hygiene, 13 (2), 83-92. doi: 10.1111/idh.12078 Teeuw, W.J., Laine, M.L., Bizzarro, S. & Loos, B.G. (2015). A lead ANRIL polymorphism is associated with elevated CRP levels in periodontitis: a pilot case-control study. PLoS One, 10 (9):e0137335. doi: 10.1371/journal.pone.0137335 Ten Cate, J.M. (2015). Models and role models. Caries Research, 49 (Suppl 1), 3-10. doi: 10.1159/000380870 Ten Harkel, B., Schoenmaker, T., Picavet, D.I., Davison, N.L., de Vries, T.J. & Everts, V. (2015). The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts. PLoS One, 10 (10):e0139564. doi: 10.1371/journal.pone.0139564 Theocharopoulou, A., Lagerweij, M.D. & van Strijp, A.J. (2015). Use of the ICDAS system and two fluorescence-based intraoral devices for examination of occlusal surfaces. European Journal of Paediatric Dentistry, 16 (1), 51-55. Theunissen, E.A.R., Bosma, S.C.J., Zuur, C.L., Spijker, R., van der Baan, S., Dreschler, W.A., de Boer, J.P., Balm, A.J.M. & Rasch, C.R.N. (2015). Sensorineural hearing loss in patients with head and neck cancer after chemoradiotherapy and radiotherapy: a systematic review of the literature. Head & Neck, 37 (2), 282-292. doi: 10.1002/hed.23551 Theunissen, E.A.R., Zuur, C.L., Józwiak, K., Lopez-Yurda, M., Hauptmann, M., Rasch, C.R.N., van der Baan, S., de Boer, J.P., Dreschler, W.A. & Balm, A.J.M. (2015). Prediction of hearing loss due to cisplatin chemoradiotherapy. JAMA Otolaryngology-Head & Neck Surgery, 141 (9), 810-815. doi: 10.1001/jamaoto.2015.1515

29 Annual Research Report 2015

Timmermans, A.J., de Gooijer, C.J., Hamming-Vrieze, O., Hilgers, F.J.M. & van den Brekel, M.W.M. (2015). T3 T4 laryngeal cancer in The Netherlands Cancer Institute; 10 year results of the consistent application of an organ preserving/ sacrificing protocol. Head & Neck, 37 (10), 1495-1503. doi: 10.1002/hed.23789 Tjang, Y.S., Suarthana, E., Körfer, R., Tenderich, G., Grobbee, D.E. & van der Heijden, G.J.M.G. (2015). A prognostic model for the thirty-day mortality risk after adult heart transplantation. Majalah Kardiologi Indonesia, 36 (1), 3-13. Tonetti, M.S., Eickholz, P., Loos, B.G., Papapanou, P., van der Velden, U., Armirage, G., Bouchard, P., Deinzer, R., Dietrich, T., Hughes, F., Kocher, T., Lang, N.P., Lopez, R., Needleman, I., Newton, T., Nibali, L., Pretzl, B., Ramseier, C., Sanz-Sanchez, I., Schlagenhauf, U. & Suvan, J.E. (2015). Principles in prevention of periodontal diseases: consensus report of group 1 of the 11th European Workshop on Periodontology on effective prevention of periodontal and peri-implant diseases. Journal of Clinical Periodontology, 42 (SI6), S5-S11. doi: 10.1111/jcpe.12368 Tytgat, S.H.A.J., Stolwijk, L.J., Keunen, K., Milstein, D.M.J., Lemmers, P.M.A. & van der Zee, D.C. (2015). Brain oxygenation during laparoscopic correction of hypertrophic pyloric stenosis. Journal of Laparoendoscopic & Advanced Surgical Techniques Part A, 25 (4), 352-357. doi: 10.1089/lap.2014.0592 Valentijn-Benz, M., van ‘t Hof, W., Bikker, F.J., Nazmi, K., Brand, H.S., Sotres, J., Lindh, L., Arnebrant, T. & Veerman, E.C.I. (2015). Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite. Caries Research, 49 (1), 9-17. doi: 10.1159/000362096 Van Dam, B.A.F.M., van der Sanden, W.J.M. & Bruers, J.J.M. (2015). Recognizing and reporting domestic violence: attitudes, experiences and behavior of Dutch dentists. BMC Oral Health, 15, 159. doi: 10.1186/s12903-015-0141-4 Van de Loo, S., Thunissen, E., Postmus, P. & van der Waal, I. (2015). Granular cell tumor of the oral cavity; a case series including a case of metachronous occurrence in the tongue and the lung. Medicina Oral Patologia Oral y Cirurgia Bucal, 20 (1), e30-e33. doi: 10.4317/medoral.19867 Van den Berg, D.P.G., de Bont, P.A.J.M., van der Vleugel, B.M., de Roos, C., de Jongh, A. & van Minnen, A. (2015). Prolonged exposure vs eye movement desensitization and reprocessing vs waiting list for posttraumatic stress disorder in patients with a psychotic disorder: a randomized clinical trial. JAMA Psychiatry, 72 (3), 259-267. doi: 10.1001/jamapsychiatry.2014.2637 Van den Berg, D.P.G., de Jongh, A., Staring, A.B.P., de Bont, P.A.J. & van der Vleugel, B.M. (2015). EMDR y psicosis: pautas de conceptualización y tratamiento. Journal of EMDR Practice and Research, 9 (1), E29-E45. doi: 10.1891/1933-3196.9.1.E29 Van den Berg, N.S., Brouwer, O.R., Schaafsma, B.E., Mathéron, H.M., Klop, W.M.C., Balm, A.J.M., van Tinteren, H., Nieweg, O.E., van Leeuwen, F.W.B. & Valdés Olmos, R.A. (2015). Multimodal surgical guidance during sentinel node biopsy for melanoma: combined gamma tracing and fluorescence imaging of the sentinel node through use of the hybrid tracer indocyanine green (99m)Tc nanocolloid. Radiology, 275 (2), 521-529. doi: 10.1148/radiol.14140322 Van den Boer, C., Lansaat, L., Muller, S.H., van den Brekel, M.W.M. & Hilgers, F.J.M. (2015). Comparative ex vivo study on humidifying function of three speaking valves with integrated heat and moisture exchanger for tracheotomised patients. Clinical Otolaryngology, 40 (6), 616-621. doi: 10.1111/coa.12426 Van den Boer, C., Muller, S.H., van der Noort, V., Valdés Olmos, R.A., Minni, A., Parilla, C., Hilgers, F.J.M. & van den Brekel, M.W.M. (2015). Effects of heat and moisture exchangers on tracheal mucociliary clearance in laryngectomized patients: a multi center case control study. European Archives of Oto-Rhino-Laryngology, 272 (11), 3439-3450. doi: 10.1007/s00405-014-3336-4 Van der Kaaij, N.C.W., van der Veen, M.H., van der Kaaij, M.A.E. & ten Cate, J.M. (2015). A prospective, randomized placebo-controlled clinical trial on the effects of a fluoride rinse on white spot lesion development and bleeding in orthodontic patients. European Journal of Oral Sciences, 123 (3), 186-193. doi: 10.1111/eos.12186 Van der Veen, M.H. (2015). Detecting short-term changes in the activity of caries lesions with the aid of new technologies. Current Oral Health Reports, 2 (2), 102-109. doi: 10.1007/s40496-015-0050-2 Van der Velden, U., Amaliya, A., Loos, B.G., Timmerman, M.F., van der Weijden, F.A., Winkel, E.G. & Abbas, F. (2015). Java project on periodontal diseases: causes of tooth loss in a cohort of untreated individuals. Journal of Clinical Periodontology, 42 (9), 824-831. doi: 10.1111/jcpe.12446 Van der Velden, U., Koster, T.J.G., Feilzer, A.J., Timmerman, M.F. & van der Weijden, G.A. (2015). In vitro evaluation of temperature changes in the root canal induced by ultrasonic scalers. International Journal of Dental Hygiene, 13 (2), 132-137. doi: 10.1111/idh.12084 Van der Waal, I. (2015). Oral leukoplakia: the ongoing discussion on definition and terminology. Medicina Oral Patologia Oral y Cirurgia Bucal, 20 (6), e685-e692. doi: 10.4317/medoral.21007

30 Academic Centre for Dentistry Amsterdam

Van der Waal, S.V., Lappin, D.F. & Crielaard, W. (2015). Does apical periodontitis have systemic consequences? The need for well-planned and carefully conducted clinical studies. British Dental Journal, 218 (9), 513-516. doi: 10.1038/sj.bdj.2015.340 Van der Waal, S.V., Oonk, C.A.M., Nieman, S.H., Wesselink, P.R., de Soet, J.J. & Crielaard, W. (2015). Additional disinfection with a modified salt solution in a root canal model. Journal of Dentistry, 43 (10), 1280-1284. doi: 10.1016/j.jdent.2015.07.015 Van der Weijden, F.A. & Slot, D.E. (2015). Efficacy of homecare regimens for mechanical plaque removal in managing gingivitis: a meta review. Journal of Clinical Periodontology, 42 (S16), S77-S91. doi: 10.1111/jcpe.12359 Van der Zande, M.M., Gorter, R.C., Aartman, I.H.A. & Wismeijer, D. (2015). Adoption and use of digital technologies among general dental practitioners in the Netherlands. PLoS One, 10 (3):e0120725. doi: 10.1371/journal.pone.0120725 Van Dijk, I.A., Nazmi, K., Bolscher, J.G.M., Veerman, E.C.I. & Stap, I. (2015). Histatin-1, a histidine-rich peptide in human saliva, promotes cell-substrate and cell-cell adhesion. The FASEB Journal, 29 (8), 3124-3132. doi: 10.1096/fj.14-266825 Van Dongen, T.M.A., Schilder, A.G.M., Venekamp, R.P., de Wit, G.A. & van der Heijden, G.J.M.G. (2015). Cost- effectiveness of treatment of acute otorrhea in children with tympanostomy tubes. Pediatrics, 135 (5), e1182-e1189. doi: 10.1542/peds.2014-3141 Van Houtem, C.M.H.H., van Wijk, A.J. & de Jongh, A. (2015). Presence, content, and characteristics of memories of individuals with dental phobia. Applied Cognitive Psychology, 29 (4), 515-523. doi: 10.1002/acp.3127 Van Houtem, C.M.H.H., van Wijk, A.J., Boomsma, D.I., Ligthart, L., Visscher, C.M. & de Jongh, A. (2015). Self- reported gagging in dentistry: prevalence, psycho-social correlates and oral health. Journal of Oral Rehabilitation, 42 (7), 487-494. doi: 10.1111/joor.12289 Van Leeuwen, M.P.C., Rosema, N.A.M., Versteeg, P.A., Slot, D.E., van Winkelhoff, A.J. & van der Weijden, G.A. (2015). Long-term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6-month randomized, vehicle-controlled clinical trial. International Journal of Dental Hygiene, 13 (2), 93-103. doi: 10.1111/idh.12082 Van Loon, J.W.L., Smeele, L.E., Hilgers, F.J.M. & van den Brekel, M.W.M. (2015). Outcome of transoral robotic surgery for stage I-II oropharyngeal cancer. European Archives of Oto-Rhino-Laryngology, 272 (1), 175-183. doi: 10.1007/s00405-014-2939-0 Van Loveren, C., Exterkate, R. & Crielaard, W. (2015). Future and past of preventive dentistry. Preface. Caries Research, 49 (Suppl 1), 1-2. doi: 10.1159/000381167 Van Monsjou, H.S., Schaapveld, M., van den Brekel, M.W.M. & Balm, A.J.M. (2015). The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV-related oropharyngeal squamous cell carcinoma: Is there really evidence for a change? Oral Oncology, 51 (10), 901-907. doi: 10.1016/j.oraloncology.2015.06.011 Van Palenstein Helderman, W.H., Groeneveld, A., van der Heijden, G.J., van Loveren, C., Holmgren, C.J. & Benzian, H. (2015). Adequate evidence to challenge the paradigm of dental caries prevention in early age? American Journal of Public Health, 105 (4), e5-e6. doi: 10.2105/AJPH.2015.302601 Van Strijp, A.J.P., Takatsuka, T., Sono, R. & Iijima, Y. (2015). Inhibition of dentin collagen degradation by hesperidin: an in situ study. European Journal of Oral Sciences, 123 (6), 447-452. doi: 10.1111/eos.12225 Van 't Hof, W., Hansenová Maňásková, S., Veerman, E.C.I. & Bolscher, J.G.M. (2015). Sortase-mediated backbone cyclization of proteins and peptides. Biological Chemistry, 396 (4), 283-293. doi: 10.1515/hsz- 2014-0260 Van Weert, S., van der Waal, I., Witte, B.I., Leemans, C.R. & Bloemena, E. (2015). Histopathological grading of adenoid cystic carcinoma of the head and neck: analysis of currently used grading systems and proposal for a simplified grading scheme. Oral Oncology, 51 (1), 71-76. doi: 10.1016/j.oraloncology.2014.10.007 Verhagen, C.V.M., de Haan, R., Hageman, F., Oostendorp, T.P.D., Carli, A.L.E., O'Connor, M.J., Jonkers, J., Verheij, M., van den Brekel, M.W. & Vens, C. (2015). Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiotherapy and Oncology, 116 (3), 358-365. doi: 10.1016/j.radonc.2015.03.028 Visscher, C.M., Ligthart, L., Schuller, A.A., Lobbezoo, F., de Jongh, A., van Houtem, C.M.H.H. & Boomsma, D.I. (2015). Comorbid disorders and sociodemographic variables in temporomandibular pain in the general Dutch population. Journal of Oral & Facial Pain and Headache, 29 (1), 51-59. doi: 10.11607/ofph.1324 Wang, J. & van der Waal, I. (2015). Disease scoring systems for oral lichen planus; a critical appraisal. Medicina Oral Patologia Oral y Cirurgia Bucal, 20 (2), e199-e204. doi: 10.4317/medoral.20524

31 Annual Research Report 2015

Weber, M.A., Milstein, D.M.J., Ince, C., Oude Rengerink, K. & Roovers, J.P.W.R. (2015). Vaginal microcirculation: Non Invasive Anatomical Examination of the Micro Vessel Architecture, Tortuosity and Capillary Density. Neurourology and Urodynamics, 34 (8), 723-729. doi: 10.1016/j.oraloncology.2015.06.011 Wignarajah, S., Suaifan, G.A.R.Y., Bizzarro, S., Bikker, F.J., Kaman, W.E. & Zourob, M. (2015). Colorimetric assay for the detection of typical biomarkers for periodontitis using a magnetic nanoparticle biosensor. Analytical Chemistry, 87 (24), 12161-12168. doi: 10.1021/acs.analchem.5b03018 Wintermans, B.B., Brandt, B.W., Vandenbroucke-Grauls, C.M.J.E. & Budding, A.E. (2015). Correction: TreeSeq, a fast and intuitive tool for analysis of whole genome and metagenomic sequence data. PLoS One, 10 (6):e0131379. doi: 10.1371/journal.pone.0131379 Zaura, E. & Mira, A. (2015). Editorial: The oral microbiome in an ecological perspective. Frontiers in Cellular and Infection Microbiology, 5:39. doi: 10.3389/fcimb.2015.00039 Zaura, E. & ten Cate, J.M. (2015). Towards understanding oral health. Caries Research, 49 (Suppl 1), 55-61. doi: 10.1159/000377733 Zaura, E., Brandt, B.W., Teixeira de Mattos, M.J., Buijs, M.J., Caspers, M.P.M., Rashid, M.U., Weintraub, A., Nord, C.E., Savell, A., Hu, Y., Coates, A.R., Hubank, M., Spratt, D.A., Wilson, M., Keijser, B.J.F. & Crielaard, W. (2015). Same exposure but two radically different responses to antibiotics: resilience of the salivary microbiome versus long-term microbial shifts in feces. MBio, 6 (6):e01693-15. doi: 10.1128/mBio.01693-15 Zhang, J., Huang, X., Huang, S., Deng, M., Xie, X., Liu, M., Liu, H., Zhou, X., Li, J. & ten Cate, J.M. (2015). Changes in composition and enamel demineralization inhibition activities of gallic acid at different pH values. Acta Odontologica Scandinavica, 73 (8), 595-601. doi: 10.3109/00016357.2015.1007478 Zhang, M., He, L.B., Exterkate, R.A.M., Cheng, L., Li, J.Y., ten Cate, J.M., Crielaard, W. & Deng, D.M. (2015). Biofilm layers affect the treatment outcomes of NaF and nano-hydroxyapatite. Journal of Dental Research, 94 (4), 602-607. doi: 10.1177/0022034514565644 Ziesemer, K.A., Mann, A.E., Sankaranarayanan, K., Schroeder, H., Ozga, A.T., Brandt, B.W., Zaura, E., Waters- Rist, A., Hoogland, M., Salazar-García, D.C., Aldenderfer, M., Speller, C., Hendy, J., Weston, D.A., MacDonald, S.J., Thomas, G.H., Collins, M.J., Lewis, C.M., Hofman, C. & Warinner, C. (2015). Intrinsic challenges in ancient microbiome reconstruction using 16S rRNA gene amplification. Scientific Reports, 5:16498. doi: 10.1038/srep16498 Zweers, J., van Doornik, A., Hogendorf, E.A.H., Quirynen, M. & van der Weijden, G.A. (2015). Clinical and radiographic evaluation of narrow- vs. regular-diameter dental implants: a 3-year follow-up. A retrospective study. Clinical Oral Implants Research, 26 (2), 149-156. doi: 10.1111/clr.12309

Scientific publications (non-refereed) Boutsioukis, C. & van der Sluis, L.W.M. (2015). Syringe irrigation: blending endodontics and fluid dynamics. In B. Basrani (Ed.), Endodontic irrigation: chemical disinfection of the root canal system (pp. 45-64). Cham: Springer. Ciancio, S., Slot, D.E., van Dyke, T., Al Bayaty, F., Aswapati, N.W., Joshi, V., Kendall, K., Leung, K., Patel, N., Pradhan, S., Senevirante, C., Takashiba, S. & Vidhali, P. (2015). Group A: consensus paper: plaque control-- home remedies practiced in developing countries. Journal of the International Academy of Periodontology, 17 (Suppl 1), 17-20. De Jongh, A. (2016). EMDR therapy for specific fears and phobias: the phobia protocol. In M. Luber (Ed.), Eye movement desensitization and reprocessing: EMDR therapy: scripted protocols and summary sheets: treating anxiety, obsessive-compusive, and mood-related conditions (pp. 9-39). New York: Springer Publishing. Frantsve-Hawley, J., Clarkson, J.E. & Slot, D.E. (2014). Using the best evidence to enhance dental hygiene decision making. Canadian Journal of Dental Hygiene, 48 (4), 187-189. Güneri, P., Epstein, J.B., Raber-Durlacher, J.E., Çankaya, H., Boyacıoğlu, H. & Barasch, A. (2015). Patient- reported outcomes for immediate identification of dental care needs. Forum of Clinical Oncology, 6 (2), 1- 7. doi: 10.1515/fco-2015-0006 Horst, F. & de Jongh, A. (2016). EMDR therapy protocol for panic disorders with or without agoraphobia. In M. Luber (Ed.), Eye movement desensitization and reprocessing: EMDR therapy: scripted protocols and summary sheets: treating anxiety, obsessive-compusive, and mood-related conditions (pp. 51-69). New York: Springer Publishing.

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Jager, D.H.J. (2015). Dental erosion: prevalence, incidence, and distribution. In B.T. Amaechi (Ed.), Dental erosion and its clinical management (pp. 3-11). Cham: Springer International Publishing. Ligtenberg, A.J.M. & Almståhl, A. (2015). Xerostomia and the oral microflora. In G. Carpenter (Ed.), Dry mouth: a clinical guide on causes, effects and treatments (pp. 81-101). Heidelberg: Springer. Logie, R. & de Jongh, A. (2015). The Flashforward Procedure. In M. Luber (Ed.), Eye movement desensitization and reprocessing: EMDR therapy: scripted protocols and summary sheets: treating anxiety, obsessive- compusive, and mood-related conditions (pp. 81-90). New York: Springer Publishing. Loos, B.G., Papantonopoulos, G., Jepsen, S. & Laine, M.L. (2015). What is the contribution of genetics to periodontal risk? The Dental Clinics of North America, 59 (4), 761-780. doi: 10.1016/j.cden.2015.06.005 Özen, B. (2015). Dental erosion. Türkiye Klinikleri Pediatri Dergisi, 1 (1), 95-99. Pathak, J.L., Jansen, I.D.C., Bravenboer, N., Klein-Nulend, J. & Bakker, A.D. (2015). Biomechanics of bone cells. In H. Simpson & P. Augat (Eds.), Experimental research methods in orthopedics and trauma (pp. 300-308). Stuttgart: Thieme. Schäfer, A.S., van der Velden, U., Laine, M.L. & Loos, B.G. (2015). Genetic susceptibility to periodontal disease: new insights and challenges. In J. Lindhe & N.P. Lang (Eds.), Clinical periodontology and implant dentistry (6th ed.). - Volume 1: basic concepts (pp. 290-310). Chichester: John Wiley & Sons, Ltd. Slot, D.E. & van der Weijden, F. (2015). Citing the literature. The Journal of the American Dental Association, 146 (11), 796. doi: 10.1016/j.adaj.2015.09.006 Slot, D.E. & van der Weijden, F.A. (2015). Current evidence on chlorhexidine, toothpaste, gels, and mouthwashes. International Journal of Evidence-Based Practice for the Dental Hygienist, 1 (1), 32-37. doi: 10.11607/ebh.001506 Slot, D.E. & van der Weijden, F.A. (2015). Group A: initiator paper: plaque control: home remedies practiced in developing countries. Journal of the International Academy of Periodontology, 17 (Suppl 1), 4-15. doi: 10.1016/j.adaj.2015.09.006 Van der Sluis, L., Boutsioukis, C., Jiang, L.M., Macedo, R., Verhaagen, B. & Versluis, M. (2015). Root canal irrigation. In L.E. Chávez de Paz, C.M. Sedgley & A. Kishen (Eds.), The root canal biofilm (Springer Series on Biofilms, 9) (pp. 259-301). Berlin: Springer. Van der Vleugel, B., van der Berg, D., de Bont, P., Staring, T. & de Jongh, A. (2015). EMDR therapy for traumatized patients with psychosis. In M. Luber (Ed.), Eye movement desensitization and reprocessing: EMDR therapy: scripted protocols and summary sheets: treating anxiety, obsessive-compusive, and mood- related conditions (pp. 97-147). New York: Springer Publishing. Van der Weijden, F., Slot, D.E., Echeverría, J.J. & Lindhe, J. (2015). Mechanical supragingival plaque control. In N.P. Lang & J. Lindhe (Eds.), Clinical periodontology and implant dentistry (6th ed.). - Volume 2: clinical concepts (pp. 677-716). Chichester: John Wiley & Sons, Ltd. Van der Weijden, F.A., van der Sluijs, E., Ciancio, S.G. & Slot, D.E. (2015). Can chemical mouthwash agents achieve plaque/gingivitis control? The Dental Clinics of North America, 59 (4), 799-829. doi: 10.1016/j.cden.2015.06.002 Van Loveren, C. & Lingström, P. (2015). Diet and dental caries. In O. Fejerskov, B. Nyvad & E. Kidd (Eds.), Dental caries: the disease and its clinical management (3rd ed.) (pp. 133-154). Oxford: Wiley Blackwell. Van Loveren, C., Schmidlin, P.R., Martens, L.C. & Amaechi, B.T. (2015). Dentin hypersensitivity: prevalence, etiology, pathogenesis, and management. In B.T. Amaechi (Ed.), Dental erosion and its clinical management (pp. 275-302). Cham: Springer International Publishing.

Professional publications Bicanic, I., de Jongh, A. & ten Broeke, E. (2015). Kritische beschouwing van de ISTSS behandelrichtlijn voor complexe PTSS bij volwassenen. Cogiscope, 2 (15), 43-44. Bicanic, I., de Jongh, A. & ten Broeke, E. (2015). Stabilisatie in traumabehandeling bij complexe PTSS: noodzaak of mythe? Tijdschrift voor Psychiatrie, 57 (5), 332-339. Bijl, D. & Baart, J.A. (2015). Geneesmiddelenbulletin. Nederlands Tandartsenblad, 70 (15), 28-29. Bijl, D. & Baart, J.A. (2015). Geneesmiddelenbulletin. Nederlands Tandartsenblad, 70 (13), 26-27. Bots, C.P. (2015). Speeksel en speekselklieren [Bespreking van het boek Speeksel en speekselklieren: betekenis voor de mondgezondheid (3e geh. herz. ed.)]. Nederlands Tijdschrift voor Tandheelkunde, 122(7-8), 423. Brand, H. & Baart, J. (2015). Komt een zwangere vrouw bij de tandarts. In I.F. van Panhuizen, M.M.J. Snoeck, G.J. van Geffen & R.R. van der Hulst (Eds.), Probleemgeoriënteerd denken voor gebruikers van lokaal anesthetica: een praktijkboek voor de opleiding en de kliniek (pp. 131-136). Utrecht: De Tijdstroom.

33 Annual Research Report 2015

Brand, H.S. (2015). Afscheidscollege prof.dr. J.M. ten Cate. Nederlands Tijdschrift voor Tandheelkunde, 122 (4), 312. Brand, H.S. (2015). Coeliakie: orale manifestaties op jonge leeftijd. De Tandartspraktijk, 36 (5), 10-13. doi: 10.1007/s12496-015-0064-y Brand, H.S. (2015). Congres 'The wild side of life': de orale gevaren van druggebruik en risicovol seksueel gedrag. Nederlands Tijdschrift voor Tandheelkunde, 122 (11), 570. Brand, H.S. (2015). Helemaal gratis. Nederlands Tijdschrift voor Tandheelkunde, 122 (6), 307. Brand, H.S. (2015). Wintersymposium over lokale anesthesie. Nederlands Tijdschrift voor Tandheelkunde, 122, 73. Broers, D.L.M., Plat, J., de Jongh, A., Zuidgeest, T.G.M., Blom, H.C.C.M., Kraaijenhagen, A.E., Pieterse, C.M. & Bildt, M.M. (2015). Toediening van intraveneuze sedatie met midazolam door tandarts is onveilig. Nederlands Tijdschrift voor Tandheelkunde, 122 (3), 139-140. doi: 10.5177/ntvt.2015.03.15109 Bruers, J.J.M., van Dam, B.A.F.M., Gorter, R. & Eijkman, M.A.J. (2015). Het welbevinden van tandartsen na een klachtenprocedure. Nederlands Tijdschrift voor Tandheelkunde, 122 (1), 41-48. doi: 10.5177/ntvt.205.01.14152 Crielaard, W. & Crielaard, L. (2015). Hygiëne en infectiepreventie, constant voortschrijdende inzichten. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (3), 7-11. Crielaard, W. & Crielaard, L. (2015). Hygiëne en infectiepreventie, constant voortschrijdende inzichten. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (6), 7-11. De Jong, T.M.H. & Laine, M.L. (2015). Halitose - adem met een luchtje. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (4), 11-15. De Jongh, A. & de Roos, C. (2015). Vierjarige wil zijn zus niet meer zien. EMDR Magazine, 3 (7), 49-51. De Jongh, A. & Hornsveld, H. (2015). Behandeling van een moordgetuige. EMDR Magazine, 3 (7), 46-47. De Jongh, A. (2015). Als stabilisatie te ver doorschiet. EMDR Magazine, 3 (9), 5-6. De Jongh, A. (2015). Angst voor de ‘Heks Doornroosje’ bij achtjarige jongen. EMDR Magazine, 3 (8), 58-59. De Jongh, A. (2015). Angst voor medische ingrepen. EMDR Magazine, 3 (8), 52-53. De Jongh, A. (2015). Behandeling na roofoverval. EMDR Magazine, 3 (7), 52-55. De Jongh, A. (2015). Behandeling van het Restless Legs Syndroom. EMDR Magazine, 3 (9), 52-53. De Jongh, A. (2015). Een vluchteling met een ernstige depressie en complexe PTSS. EMDR Magazine, 3 (8), 47- 49. De Jongh, A. (2015). EMDR bij je eigen kind. EMDR Magazine, 3 (7), 48. De Jongh, A. (2015). EMDR bij vergevorderde dementie. EMDR Magazine, 3 (8), 50-51. De Jongh, A. (2015). EMDR gericht op flashforwards voor jaloersheid. EMDR Magazine, 3 (8), 56-57. De Jongh, A. (2015). Man op zolder gevonden na suïcide. Wat als de vermijding blijft. EMDR Magazine, 3 (8), 54-55. De Jongh, A. (2015). Niet kunnen spreken over verkrachting. EMDR Magazine, 3 (7), 58-60. De Jongh, A. (2015). Patiënt met evenwichtsproblemen. EMDR Magazine, 3 (9), 55. De Jongh, A. (2015). Vrouw met vogelfobie. Deel 1. EMDR Magazine, 3 (7), 42-45. De Jongh, A. (2015). Vrouw met vogelfobie. Deel 2. EMDR Magazine, 3 (8), 41-43. De Jongh, A. (2015). Zorgen over de scherp gevoerde stabilisatiediscussie. EMDR Magazine, 3 (9), 14-15. De Jongh, A., Bicanic, I. & de Roos, C. (2015). Vluchtelingen in de praktijk (vervolg). Reactie op Laban, C.J. Veerkrachtgerichte behandeling vluchtelingen. Nederlands Tijdschrift voor Geneeskunde https://www.ntvg.nl/artikelen/vluchtelingen-de-praktijk/reacties#comment-7005. De Jongh, A., Bicanic, I. & de Roos, C. (2015). Vluchtelingen zijn beter te helpen met PTSS-behandelingen. Reactie op Lamkaddem, M., van den Muijsenbergh, M. Laban, K. Vluchtelingen in de praktijk. Persoonsgerichte zorg en veerkracht-gericht werken. Persoonsgerichte zorg en veerkracht-gericht werken. Ned Tijdschr Geneeskd. 2015;159:A9447. https://www.ntvg.nl/artikelen/vluchtelingen-de-praktijk. De Jongh, A., Bicanic, I., van Minnen, A., ten Broeke, E. & van der Gaag, M. (2015). Complexe PTSS na vroegkinderlijk trauma: emotieregulatietraining als aanvulling op de PTSS richtlijn. Tijdschrift voor Psychiatrie, 57 (6), 471-473. De Jongh, A., Said Afellad, S. & Pieterse, C.M. (2015). Een patiënt met Somatisch Onvoldoende verklaarde Lichamelijke Klachten (SOLK). Quality Practice. Nascholingstijdschrift voor Tandartsen, 11 (2), 42-46. De Lange, J. (2015). Kankerbehandeling en mondgezondheid [Bespreking van het boek Factors influencing oral health during cancer treatment: emphasis on the relationshipbetween the oral microbiome and oral mucositis]. Nederlands Tijdschrift voor Tandheelkunde, 122(5), 299. De Soet, J.J. (2015). Proefschriften 25 jaar na dato 42. Tandcariës en de rol van specifieke bacteriën. Nederlands Tijdschrift voor Tandheelkunde, 122 (10), 525-531. doi: 10.5177/ntvt.2015.10.15177

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De Soet, J.J., Laheij, A.M.G.A. & Volgenant, C.M.C. (2015). Ontwikkeling van de richtlijn Infectiepreventie in mondzorgpraktijken. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (3), 15-20. De Soet, J.J., Laheij, A.M.G.A. & Volgenant, C.M.C. (2015). Ontwikkeling van de richtlijn Infectiepreventie in mondzorgpraktijken. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (6), 15-20. De Visscher, J.G.A.M. (2015). Mondafwijking: naar de huisarts? Nederlands Tijdschrift voor Tandheelkunde, 122 (7-8), 367. Den Dekker, J. (2015). Proefschriften 25 jaar na dato 40. Behandelingsplanning in de tandartspraktijk. Nederlands Tijdschrift voor Tandheelkunde, 122 (7-8), 378-382. doi: 10.5177/ntvt.2015.07/08.14263 Duijster, D. & de Jong-Lenters, M. (2015). De rol van het gezin in de preventie van cariës bij kinderen. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (2), 26-30. Eijkman, M.A.J. (2015). Buitenlandse tandartsen. Nederlands Tijdschrift voor Tandheelkunde, 122 (9), 431. Eijkman, M.A.J. (2015). Symposium evidence-based medicine. Nederlands Tijdschrift voor Tandheelkunde, 122 (11), 570. Eijkman, M.A.J. (2015). Tandarts-adviseurs en professioneel handelen. Nederlands Tijdschrift voor Tandheelkunde, 122 (2), 67. Elfrink, M.E.C. & Krikken, J.B. (2015). Kaasmolaren: nieuwe ontwikkeling op onderzoeksgebied. Nederlands Tandartsenblad, 8 (13), 24. Elkerbout, T.A., Slot, D.E. & van der Weijden, G.A. (2015). Chloorhexidine een tandpasta met SLS: kan dat nu wel of niet? Nederlands Tijdschrift voor Mondhygiëne, 5, 36. Gruythuysen, R.J.M., van Loveren, C., Wiggelendam, J.M., van Boven, J.A. & Burgersdijk, R.C.W. (2015). Verwaarlozing van de mondverzorging bij kinderen: een kwestie van integrale aanpak. Nederlands Tijdschrift voor Geneeskunde, 159 (7):A8071. Hopman, A.J.G., Baart, J.A. & Brand, H.S. (2015). Articaïne en neurotoxiciteit. In J.K.M. Aps, M. de Bruyne, R. Jacobs, M.E.L. Nienhuijs & W.J. van der Meer (Eds.), Het tandheelkundig jaar 2016 (pp. 109-122). Houten: Bohn Stafleu van Loghum. Janssen, M.J.E.J., Brand, H.S. & Bots, C.P. (2015). Elektrostimulatie voor de behandeling van een drogemondgevoel. Nederlands Tijdschrift voor Tandheelkunde, 122 (10), 517-520. doi: 10.5177/ntvt.2015.10.15130 Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 10: "Vander siecheit der tonghe". Nederlands Tijdschrift voor Tandheelkunde, 122 (11), 573. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 11: "Dat cacabeen uter stede" en het "wijf van Poperingen". Nederlands Tijdschrift voor Tandheelkunde, 122 (12), 661. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 1: "Een blom van surgien". Nederlands Tijdschrift voor Tandheelkunde, 122 (1), 19. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 2: "Daarom lieve kinder ontfaet dit werc blidelike". Nederlands Tijdschrift voor Tandheelkunde, 122 (2), 77. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 3: "Van die ghebreken der tanden". Nederlands Tijdschrift voor Tandheelkunde, 122 (3), 141. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 4: "Van den tanden die siin gegaet". Nederlands Tijdschrift voor Tandheelkunde, 122 (4), 188. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 5: "Van tanden uut te doene metter wortele". Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 251. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 6: "Van enen ontbonden tant ende van die vuyle verve der tanden". Nederlands Tijdschrift voor Tandheelkunde, 122 (6), 316. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 7: "Van den huve ende datter toe behoert". Nederlands Tijdschrift voor Tandheelkunde, 122 (7-8), 376. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 8: "Eenre vrouw die hadde squinantie". Nederlands Tijdschrift voor Tandheelkunde, 122 (9), 441. Jonkman, E.J. & Eijkman, M.A.J. (2015). Middeleeuwse tandheelkunde in de Lage Landen 9: "Dits van den tantvlesche". Nederlands Tijdschrift voor Tandheelkunde, 122 (10), 515. Kraaijenga, S.A.C., van den Brekel, M.W.M., Smeele, L.E. & Lapid, O. (2015). Herstel van slik- en stemfunctie met behulp van lipofilling in de mond of keelholte na behandeling voor hoofd- halskanker. Nederlands Tijdschrift voor Plastische Chirurgie, 6 (1), 31-36. Krom, B.P. (2015). Microbiële biofilms in tandheelkunde. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (6), 21-24.

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Krom, B.P. (2015). Microbiële biofilms in tandheelkunde. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (3), 21-24. Laine, M.L. (2015). Halitose in de tandartspraktijk. In J.K.M. Aps, M. de Bruyne, R. Jacobs, M.E.L. Nienhuijs & W.J. van der Meer (Eds.), Het tandheelkundig jaar 2016 (pp. 137-145). Houten: Bohn Stafleu van Loghum. Loos, B.G. (2015). Link mond- en algemene gezondheid [Bespreking van het boek The oral-systematic health connection: a guide to patient care]. Nederlands Tijdschrift voor Tandheelkunde, 122(5), 299. Loos, B.G. (2015). The heart and mouth connection. Dimensions of Dental Hygiene, 13 (2), 47-52. Louropoulou, A. (2015). Anna Louropoulou: 'Peri-implantitis vraagt om eenduidige behandelafspraken'. NVvP- Nieuwsbrief, 88, 6-7. Mettes, T.G., van Loveren, C., van Oirschot, B.A., van Maanen-Schakel, N.W.D., van der Weijden, G.A. & Bruers, J.J.M. (2015). Evidencebased klinische praktijkrichtlijnen in de mondzorg 2: proces en inhoud van evidencebased richtlijnontwikkeling. Nederlands Tijdschrift voor Tandheelkunde, 122 (1), 21-31. doi: 10.5177/ntvt.2015.01.14208 Moinzadeh, A.T., Jongsma, L., Groot-Kuin, D., Neirynck, N., Cristescu, R. & Camilleri, J. (2015). Endodontologie in beweging: nieuwe concepten, materialen en technieken 1. Hydraulische calciumsilicaatcementen. Nederlands Tijdschrift voor Tandheelkunde, 122 (7-8), 405-414. doi: 10.5177/ntvt.2015.07/08.15146 Özok, A.R. & Metska, M.E. (2015). Endodontologie in beweging: nieuwe concepten, materialen en technieken 2. Conebeamcomputertomografie in de endodontische diagnostiek en behandelplanning. Nederlands Tijdschrift voor Tandheelkunde, 122 (9), 465-472. doi: 10.5177/ntvt.2015.09.15148 Pull ter Gunne, L.P. & van der Weijden, F. (2015). Een gevoelloos onderwerp. Dentista, 12. Slot, D.E. (2014). Cuestionamiento de la evidencia. Oral Health Dialoque, 2014 (1), 9-10. Slot, D.E. (2014). Mettere in discussione le evidenze. Oral Health Dialoque, 2014, 9-10. Slot, D.E. (2015). Interroger la littérature scientifique et les preuves. Oral Health Dialoque, 2015 (1), 9-10. Slot, D.E., Suvan, J.E. & van der Weijden, F.A. (2015). [Bespreking van het boek Ultrasonic periodontal debridement: theory and technique]. International Journal of Dental Hygiene, 13(3), 236. Ten Broeke, E., Beer, R., de Jongh, A. & Lindauer, R. (2015). Vraagtekens bij de behandeling van psychogene niet-epileptische aanvallen. Gedragstherapie, 48 (1), 70-76. Thomas, R.Z., Loos, B.G., Teeuw, W., Kunnen, A., van Winkelhoff, A.J. & Abbas, F. (2015). Parodontitis en systemische ziekten - van wetenschap naar praktijk. Nederlands Tijdschrift voor Tandheelkunde, 122 (10), 542-548. doi: 10.5177/ntvt.2015.10.15134 Ting, J.W., Sheik Rashid, M., Dreschler, W.A. & Brand, H.S. (2015). Tandartsen en beroepsgerelateerde lawaaislechthorendheid. In J.K.M. Aps, M. de Bruyne, R. Jacobs, M.E.L. Nienhuijs & W.J. van der Meer (Eds.), Het tandheelkundig jaar 2016 (pp. 15-26). Houten: Bohn Stafleu van Loghum. Van Dam, B.A.F.M., Gorter, R.C., Eijkman, M.A.J. & Bruers, J.J.M. (2015). De KNMT-klachtenregeling beoordeeld door tandartsen. Nederlands Tijdschrift voor Tandheelkunde, 122 (2), 101-108. doi: 10.5177/ntvt.2015.02.14164 Van Dam, B.A.F.M., Oosterkamp, B.C.M., den Boer, J.C.L. & Bruers, J.J.M. (2015). Evidencebased klinische praktijkrichtlijnen in de mondzorg 3: draagvlak voor richtlijnontwikkeling in de mondzorg. Nederlands Tijdschrift voor Tandheelkunde, 122 (2), 85-92. doi: 10.5177/ntvt.2015.02.14232 Van der Heijden, G.J.M.G. (2015). Relevante richtlijnen: knelpunten en oplossingen. Nederlands Tandartsenblad, 70 (11), 34. Van der Sanden, W.J.M., Gorter, R. & Tams, J. (2015). Evidencebased klinische praktijkrichtlijnen in de mondzorg 6. Praktijkrichtlijnen in de opleiding tot tandarts. Nederlands Tijdschrift voor Tandheelkunde, 122 (9), 475-482. doi: 10.5177/ntvt.2015.09.15135 Van der Sluijs, E., Slot, D.E. & van der Weijden, G.A. (2015). Water en slechte ochtendadem. NVvP- Nieuwsbrief, 90 (12), 14. Van der Waal, I. (2015). Een geel knobbeltje in het mondslijmvlies: verwijzing naar kaakchirurg wordt aanbevolen. De Tandartspraktijk, 36 (6), 52-53. doi: 10.1007/s12496-015-0089-1 Van der Waal, I. (2015). Een mandibulaire radiolucentie met consequenties: verwijzing naar de kaakchirurg is geïndiceerd. De Tandartspraktijk, 36 (7), 46-47. doi: 10.1007/s12496-015-0104-6 Van der Waal, I. (2015). Gingivitisachtige aandoeningen: verwijzing naar de kaakchirurg is geïndiceerd. De Tandartspraktijk, 36 (8), 40-41. doi: 10.1007/s12496-015-0119-z Van der Waal, I. (2015). Melanoom van de mond: verwijzing naar de kaakchirurg wordt geadviseerd. De Tandartspraktijk, 36 (9), 39-41. doi: 10.1007/s12496-015-0133-1 Van der Waal, I. (2015). Mond- en kaakziekten: een atlas voor de dagelijkse praktijk (3e herz. druk). Houten: Bohn Stafleu van Loghum.

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Van der Waal, I. (2015). Ongewone laesie op de tongrug: verwijzing naar kaakchirurg is geïndiceerd. De Tandartspraktijk, 36 (4), 34-35. doi: 10.1007/s12496-015-0057-9 Van der Waal, I. (2015). Ongewone periapicale radiolucentie rond 37: verwijzing naar kaakchirurg wordt aanbevolen. De Tandartspraktijk, 36 (5), 46-47. doi: 10.1007/s12496-015-0072-y Van der Waal, I. (2015). Premaligne afwijkingen van het mondslijmvlies. Quality Practice Assistenten, 3 (1), 13- 21. Van der Waal, I. (2015). Witte veranderingen in de gingiva: wat te doen? De Tandartspraktijk, 36 (1), 56-57. doi: 10.1007/s12496-015-0013-8 Van der Waal, I. (2015). Zwelling van de bovenlip: verwijzing naar kaakchirurg is geïndiceerd. De Tandartspraktijk, 36 (3), 46-47. doi: 10.1007/s12496-015-0043-2 Van der Waal, I. (2015). Zwelling van de mondbodem: 'kikkergezwel' bij 11-jarig meisje. De Tandartspraktijk, 36 (2), 38-39. doi: 10.1007/s12496-015-0027-2 Van der Waal, S., Connert, T., Laheij, A., de Soet, J. & Wesselink, P. (2015). Vrij beschikbaar chloor in NaOCl- oplossingen voor endodontische irrigatie: kloppen de verwachtingen? Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (5), 23-29. Van der Waal, S.V. & de Soet, J.J. (2015). Endodontologie in beweging: nieuwe concepten, materialen en technieken 4. Wortelkanaaldesinfectie anno 2015. Nederlands Tijdschrift voor Tandheelkunde, 122 (12), 683-689. doi: 10.5177/ntvt.2015.12.15191 Van der Weijden, F. & Slot, D.E. (2015). Oil-pulling: hoax of heilzaam? Olie Trekken. Dentista, 2015 (5), 36-39. Van der Weijden, F. & Slot, D.E. (2015). Verslag symposium 23 april: 'The best evidence for dental hygiene practice'. NVvP-Nieuwsbrief, 89 (9), 8-9. Van der Weijden, F. (2015). Casus: behandeling in het buitenland. If you pay peanuts... Dentista, 2015 (2), 16- 19. Van der Weijden, F. (2015). Struisvogelimplantologie. Dentista, 2015 (3), 48-51. Van Diermen, D.E. (2015). Kleine kwalen in de mondzorgpraktijk: koortslip, aften, zweertjes en schimmels in de mond. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (4), 7-10. Van Houtem, C.M.H.H. & de Jongh, A. (2015). Kokhalzen bij de tandheelkundige behandeling: onbegrepen maakt onbehandelbaar? Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (4), 27-30. Van Lieshout, M. & Bonifácio, C. (2015). Diepte-infiltratie: zonder boren en anesthesie, en minimaal invasief. De Tandartspraktijk, 36 (9), 4-9. doi: 10.1007/s12496-015-0124-2 Van Loveren, C. & Stel, G. (2015). Risicoschatting bij cariësdiagnostiek en -behandeling: naslagwerk bij de onlinecursus (AccreDidact. Tandartsen, 1-2015). Houten: AccreDidact. Van Loveren, C. & van Palenstein Helderman, W.H. (2015). Regelmatig en zorgvuldig tandenpoetsen met fluoridetandpasta is de basis van preventie. Quality Practice Assistenten, 3 (1), 35-41. Van Loveren, C. (2015). Chloorhexidine en lasers in de parodontologie [Bespreking van het boek Prevention of gingivitis and treatment of periodontitis-chloorhexidine gels and dental lasers]. Nederlands Tijdschrift voor Tandheelkunde, 122(12), 703. Van Loveren, C., Bruers, J.J.M. & van der Heijden, G.J.M.G. (2015). Stand van zaken. Evidencebased richtlijnen voor de mondzorg. Nederlands Tijdschrift voor Geneeskunde, 159 (18):A7997. Van Palenstein Helderman, W.H., Gruythuysen, R.J.M., Bruers, J.J.M., van Strijp, A.J.P. & van Loveren, C. (2015). Een omslag in cariësbehandeling bij kinderen: 'Gewoon Gaaf'. Nederlands Tijdschrift voor Tandheelkunde, 122 (3), 132-138. doi: 10.5177/ntvt.2015.03.14221 Van Strijp, A.J.P., van Amerongen, J.P., de Kloet, H.J., van Loveren, C., Penning, C., Roeters, F.J.M. & Verhoef, A. (2015). Carieslaesies: diagnose en behandeling (6e geh. herz. druk). Houten: Prelum. Vermaire, J.H. & van Loveren, C. (2015). Cariëspreventieve strategieën bij 6-jarigen: een gerandomiseerd, gecontroleerd onderzoek. Nederlands Tijdschrift voor Tandheelkunde, 122 (4), 200-208. doi: 10.5177/ntvt.2015.04.14265 Vermaire, J.H., van Loveren, C., Brouwer, W.B.F. & Krol, M. (2015). Een economische evaluatie van 2 cariëspreventieve strategieën vergeleken met standaardzorg. Nederlands Tijdschrift voor Tandheelkunde, 122 (7-8), 392-401. doi: 10.5177/ntvt.2015.07/08.15144 Warnsinck, C.J., Koutris, M., Lobbezoo, F. & Shemesh, H. (2015). Persisterende pijn in het dento-alveolaire gebied. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 8 (1), 12-16. Warnsinck, C.J., Koutris, M., Shemesh, H. & Lobbezoo, F. (2015). Persisterende dentoalveolaire pijn (PDAP). Nederlands Tijdschrift voor Tandheelkunde, 122 (2), 95-100. doi: 10.5177/ntvt.2015.02.14189 Zaura, E. (2015). Resultaten van de QP-leden-enquête over infectiepreventie in de mondzorgpraktijk. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (3), 25-28.

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Zaura, E. (2015). Resultaten van de QP-leden-enquête over infectiepreventie in de mondzorgpraktijk. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (6), 25-28.

Publications for the general public Brand, H.S. (2015, September 14). Tandglazuur. Brief aan de redactie. Volkskrant. De Jongh, A. (2015). Boos, bezorgd, jaloers? Donkere emoties en hun zonnige kant. Psychologie Magazine, 34 (4), 53-57. De Jongh, A. (2015). Ik ben bang: 5 angstdeskundigen geven een kijkje in de ziel. Radar+, 16 (12), 66. De Jongh, A. (2015). Ik vind veel dingen eng. Psychologie Magazine, 34 (3). Eijkman, M.A.J. (2015, April 03). Gebit vegetariërs hebben meer gaatjes en tanderosie dan vleeseters. NRC Handelsblad. Eijkman, M.A.J. (2015, April 30). Impact van klachten groot. NRC Handelsblad. Opiniepagina. Eijkman, M.A.J. (2015, February 14). Ontstoken mond bedreigt zwangerschap. NRC Handelsblad. Eijkman, M.A.J. (2015, November 17). Boventand eruit geslagen? Trek een kies en laat die vastgroeien op de plek van de verloren voortand. NRC Next. Eijkman, M.A.J. (2015, October 17). Meer tandzorg nodig in verpleeghuis. NRC Handelsblad. Ligtenberg, A.J.M. (2015, June 20). Voor cariës is belangrijk hoe vaak je suiker eet, niet hoeveel. NRC Handelsblad. Van Hoften, R.L. & Brand, H.S. (2015). Polyposis en mondgezondheid. Lynch Polyposis Contactblad, 9, 15.

Patents Deng, D.M. & Crielaard, W. (2015) Compositions comprising anticariogenic bacteria and fermentable saccharides. Number: EP15170363. Janus, M.M., Krom, B.P., Crielaard, W. & Keijser, B.J.F. (2015) Inhibition of maturation of dental biofilm and cariogenic properties. Document number: P100157PC00. Application number: PCT/EP2015/070551.

Grants: current projects with external funding Bolscher, J.G.M. & Veerman, E.C.I. (2015). Co-investigators project on Applying histatin-1 to improve integration of dental implants. ITI research grant (International team for Implantology). Grant no. 1091- 2015, during six months 2015-2016, (€ 37607). Principal Investigator: Dr. J. Stap, Core facility Cellular Imaging / LCAM-AMC, Academic Medical Center, University of Amsterdam: (2015, January 01 - 2016, December 31). Bolscher, J.G.M. (2015). Co‐investigator of research project on Effect of lactoferrin chimera on periodontal pathogen and subgingival biofilm formation in vitro. Granted total 225,000 Thai baht by Khon Kaen University (Grant no. 560029), during 2014-2015: Principal Investigator: Prof.dr. S. Taweechaisupapong, Faculty of Dentistry, Department of Oral Diagnosis, Khon Kaen University, Thailand (2014, January 01 - 2015, December 31). Bolscher, J.G.M. (2015). Co‐investigator of research project on Starvation response, biofilm formation and drug tolerance in Burkholderia pseudomallei, granted by the Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (Grant no. PHD/0351/2551) during 6 years (2010-2016). Granted total 1,555,000 Thai baht; covering PhD‐student MSc. A. Chitchanok visits to ACTA and visits of co‐investigator to Khon Kaen University.: Principal Investigator: Prof. dr. S. Taweechaisupapong, Faculty of Dentistry, Department of Oral Diagnosis,Khon Kaen University, Thailand (2010, January 01 - 2016, December 31). Crielaard, W. Collaboration research on anti-caries biomaterials containing nanoparticles. International Science and Technology Cooperation Program of China (2014DFE30180). Granted 1.22 million RMB. Principal investigators: Xuedong Zhou (PI), Lei Cheng, Jiyao Li. Collaborators: ACTA, the Netherlands; Saarland University, Germany (2014, November 01, 2016, November 01). Crielaard, W., Laine, M.L. & Zaura, E. (2015). The effect of Glymur rinse on oral microbiological changes and changes in microbial activity related to halitosis. Glymur, granted €198.613 (excl. VAT): (2015, mei 06 - 2015, november 23). Crielaard, W. & Loos, B.G. (2015). Preventive Dentistry, Periodontology, Oral Biochemistry, Cariology, TIFN Oral Health. Public Private Partnership funded by the Dutch Ministry of Economic Affairs, Wrigley, Philips

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Research, Cargill, GlaxoSmithKline, TNO, WUR & ACTA (total investment 5.2 M€): (2012, January 01 - 2016, January 01). Crielaard, W. & Krom, B.P. (2015). Studying dynamics in complex microbial biofilms. NWO Middelgroot, granted €164.000: (2013, January 01 - 2017, January 01). Deng, D.M. & Wu, G. (2015). Application of a novel local antimicrobial delivery and osteconductive system on decontaminated implant surfaces to promote re-osseointegration. ITI Foundation research grant, 1034_2014 (Principal investigator) (01-07-2015 till 30-06-2017), granted 37,798 Euro: (2015, July 01 - 2017, June 30). Deng, D.M., Wesselink, P.R. & Crielaard, W. (2015). Novel molecular methods to rediscover the role of microorganisms in persistent apical periodontitis. KNAW Grant 12CDP05. Cooperation Guanghua school of Stomatology, Sun Yat-sen University Guangzhou, granted k€60: (2012, January 01 - 2016, January 01). De Soet, J.J., Crielaard, W. & Zaura, E. (2015). Biofilm composition and secondary caries in situ and in vivo. NIH grant 10504620. Radboud University Nijmegen Medical Centre, Federal University of Pelotas, School of Dentistry and Preventive Dentistry ACTA, granted $955,608: (2011, January 01 - 2015, July 01). De Soet, J.J. & Laheij, A.M.G.A. (2015). The influence of the oral microbiome and salivary proteome on oral complications in hematopoietic stem cell transplantation recipients. H-OME study. Granted 563.100 Euro. Principal investigators: J.E. Raber. F.R. Rozema & N.M.A. Blijlevens: (2015, May 01 - 2019, May 01). Exterkate, R.A.M. & Crielaard, W. (2015). Effect of S-PRG eluent on in-vitro biofilms. Commissioned Research Shofu Inc Japan, granted €22000: (2014, September 01 - 2015, February 01). Exterkate, R.A.M. & Crielaard, W. (2015). Effect of treatment start and frequency on efficacy of oral rinses in a polymicrobial biofilm model. Colgate-Palmolive Europe sàrl, granted €9000: (2014, September 01 - 2015, February 01). Exterkate, R.A.M. & Crielaard, W. (2015). Short report on the effect of experimental rinses and toothpastes on polymicrobial biofilms in an Active Attachment Biofilm model. Commissioned Research Colgate Palmolive Europe Sarl, granted €9000: (2015, January 01). Exterkate, R.A.M. & Crielaard, W. (2015). Standard test method for detecting seal leaks in porous medical packaging by dye penetration according to standard F1929-12. Commissioned Research DuxDental, the Netherlands granted €5000: (2015, January 01). Gorter, R.C. & Wismeijer, D. (2015). Digital dentistry in practice; On dentists' interaction with technological transformations. ITI research grant, to the amount of CHF 123.821: (2015, January 01 - 2015, December 31). Jager, D.H.J. (2015). A randomized, double blind (sponsor open), comparative, multi-center study to evaluate the safety and efficacy of subcutaneous belimumab (GSK1550188) and intravenous rituximab co- administration in subjects with primary Sjögren’s syndrome. GlaxoSmithKline plc Grant €114.000,-: (2015, January 01). Jager, D.H.J. & Karagozoglu, K.H. (2015). Endoscopic treatment of salivary glands affected by Sjogren’s Syndrome. Grant €45.000 (in kind): (2015, January 01). Krom, B.P. & Hoogenkamp, M.A. (2015). Effect of probiotic bacteria on biofilm formation Candida albicans. Winclove BV. granted 9075 euro: (2015, January 01 - 2015, December 31). Krom, B.P. (2015). Effect of quorum sensing inhibitors on biofilm formation in an ex vivo burn wound model. The National Institute for Biotechnology in the Negev Ltd. Be'er-Sheva, Israel, granted 2650 euro: (2015, January 01 - 2016, December 31). Krom, B.P., Brandt, B.W. & Exterkate, R.A.M. (2015). Plaque on white spots is different compared to plaque on dental enamel. GlaxoSmithKline, granted 15.000 euro: (2015, January 01 - 2016, December 31). Laine, M.L. & Loos, B.G. (2015). BioMet3i: The regeneration of peri-implantitis defects BEATRIX. Granted €39.900,-: (2014, January 01 - 2016, January 01). Loos, B.G. & Teeuw, W.J. (2015). The implementation of oral care ORADIA. Sunstar, granted €171.000,-: (2014, January 01 - 2017, January 01). Raber-Durlacher, J.E., Rozema, F.R. & Blijlevens, N.M.A. (2015). The influence of the oral microbiome and salivary proteome on oral complications in hematopoietic stem cells: the H-OME study. Dutch Cancer Society grant (KWF) 2014-6829: (2014, January 01). Smeele, L.E. (2015). Quantification of treatment-induced growth disruption using 3D photography in children with orbital rhabdomyosarcoma. Stichting ODAS, granted €87.827: (2016, January 01 - 2017, January 01). Ten Cate, J.M., Crielaard, W., de Soet, J.J., van Loveren, C., van der Veen, M.H. & Volgenant, C.M.C. (2015). Seeing is believing. STW project; granted € 500.000: (2010, October 01 - 2016, October 01).

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Van de Ven, R., Bloemena, E. & Leemans, C.R. (2015). Characterizing a new immune checkpoint in HPV negative head and neck cancers: exploring prognostic and therapeutic value. VUmc CCA grant €750000: (2014, December 31 - 2015, December 31). Van der Heijden, G.J.M.G. (2015). ADVOCATE -Adding value to oral care. Horizon 2020 Research Program, PHC-23-2014, European Union EU, granted 6M€: (2015, May 01 - 2019, June 01). Van Wijk, A.J. & van der Heijden, G.J.M.G. (2015). Responsiveness of the OHIP-14 in patients with dentures. Stichting Miletus, Zeist, granted 50K€: (2014, January 01 - 2015, December 31). Veerman, E.C.I. & Bikker, F.J. (2015). Comparison of inhibiting adhesion of Streptococcus mutans to Hydroxyapatite. Sunstar Suisse, granted 15 K€ (2015, September 01 - 2016, August 31). Veerman, E.C.I. & Bikker, F.J. (2015). Functional food mondspray met ovomucine-bevattende microdruppels te bestrijding van het droge mond syndroom. TKI-Agrifood, 150 k€: (2015, January 01 - 2019, December 31). Veerman, E.C.I. (2015). How histatin enhances wound closure: structural and cellular aspects. NWO-ALW, granted 280 K€: (2011, January 01 - 2015, December 31). Veerman, E.C.I. (2015). Novel strategies to enhance oral health. Top Institute Food and Nutrition, 1 AIO: (2012, January 01 - 2016, December 31). Wismeijer, D., Bruers, J.J.M. & Reijers, H. (2015). Data mining naar de kosten effectiviteit van implantaatgedragen overkappingsprotheses in bestanden van de zorgverzekeraars. NWO project, Post Doc voor 1 jaar, granted €30.000,-: (2015, January 01 - 2015, December 31). Zaura, E. (2015). The effect of Philips Sonicare AirFloss Ultra plus Listerine Cool Mint compared to dental floss on gingival bleeding, dental plaque and gingival abrasion in a healing of experimental gingivitis model. Commissioned research Philips Healthcare, granted €90.000 (total investment €300.000): (2015, January 01 - 2016, December 31). Zaura, E. (2015). Transversal skills in dentistry: content and language integrated learning approach. ERASMUS+ strategic partnership project AGREEMENT No – 2015-1-LV01-KA203-013401– P3, granted €12668: (2015, December 01 - 2017, November 30).

Indicators of Esteem

Scientific awards/honours De Jongh, A. (2015). Peter Makkesprijs 2015. Uitreiking 18-3-2016 op congres van de Vereniging tot Bevordering van de Tandheelkundige Gezondheidszorg voor Gehandicapten (VBTGG) en de Nederlandse Vereniging voor Kindertandheelkunde (NvVK): (2015, October 29 - 2016, March 18). Elkerbout, T.A. (2015). Mondhygiënist van het jaar 2015, award €1000. 14th VPM-congress, Vereniging ter Promotie van Mondhygiëne (VPM): Ede, the Netherlands (2015, September 18). Liao, Y. (2015). ORCA Nathan Cochrane Junior Scientist’s Award for the best poster on Identification and functional analysis of genome mutations in a fluoride-resistant Streptococcus mutans strain (co-authors J. Chen, B.W. Brandt, Y. Zhu, J. Li, C. van Loveren, D.M. Deng). 62nd ORCA Annual Congress: Brussels, Belgium (2015, July 01 - 2015, July 04). Mirmohammadi, H. (2015). Dr. Ahmad Hedayat Award. Granted for writing the book chapter: Advances in ceramic matrix composites: 14th Annual Dental Symposium, Isfahan, Iran (2015, March 20). Slot, D.E. (2015). NVvP-Preventieprijs 2015. Najaarscongres Nederlandse Vereniging voor Parodontologie (NVvP): Ede, the Netherlands (2015, November 27). Tan, J. & Stein Callenfels, D. (2015). Publieksprijs en 2e prijs NT-GSK Award. The role of the labial biopsy in Sjögren’s syndrome: Groningen, the Netherlands (2015, June 25). Van der Waal, I. (2015). Honorary member. Society of Medicine and Natural Sciences: University of Parma, Parma, Italy (2015, May 22). Van der Waal, S.V. (2015). WTA-Hamer Duyvenszprijs. Nederlandse Vereniging Tandheelkunde: Amsterdam, the Netherlands (2015, November 09).

Memberships editorial board Aartman, I.H.A.: European Journal of Dental Education. Bloemena, E.: ISRN Gastroenterology.

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Bloemena, E.: Scandinavian Journal of Gastroenterology. Bloemena, E.: World Journal of Gastrointestinal Oncology. Brand, H.S.: Nederlands Tijdschrift voor Tandheelkunde. Crielaard, W.: Critical Reviews in Microbiology. Crielaard, W.: Microbiology – SGM. De Jongh, A.: European Journal of Psychotraumatology. De Jongh, A.: Journal of EMDR Practice and Research. Gorter, R.C.: European Journal of Dental Education. Krom, B.P.: Odontology. Laheij, A.M.G.A.: ACTA Quality Practice. Van der Waal, I.: Acta Stomatologica Croatica. Van der Waal, I.: European Journal of Cancer. Van der Waal, I.: Journal of Dentistry University of Sao Paolo. Van der Waal, I.: Journal of Oral and Maxillofacial Surgery. Van der Waal, I.: Medicina Oral. Van der Waal, I.: Minerva Stomatologica. Van der Waal, I.: Nederlands Tijdschrift voor Geneeskunde. Van der Waal, I.: Oral Health and Preventive Dentistry. Van der Waal, I.: Oral Oncology. Van der Waal, I.: Padjadjaran Journal of Dentistry. Van der Waal, I.: STOMA. Veerman, E.C.I.: Odontology. Zaura, E.: Caries Research. Laine, M.L.: Current Oral Health Reports. Loos, B.G.: Journal of Clinical Periodontology. Loos, B.G.: Oral Health and Preventive Dentistry. Raber-Durlacher, J.E.: Mediterranean Oncology Journal. Raber-Durlacher, J.E: Periodontics and Prosthodontics. Slot, D.E.: International Journal of Dental Hygiene. Van der Weijden, G.A.: International Journal of Dental Hygiene.

Organization of (inter)national scientific congresses and symposia Crielaard, W. (2015). Organizer. Oral Microbiology and Immunology Group Postgraduate Prize Meeting: ACTA, Amsterdam, the Netherlands (2015, February 12). Crielaard, W. & Keijser, B.J.F. (2015). Organizing committee. TIFN & ACTA sponsored symposia. 47th Meeting CED-IADR: Antalya, Turkey (2015, October 15 - 2015, October 17). Jager, D.H.J. (2015). Member organizing committee. ISMR congres: Supportive care in head and neck rehabilitation: Groningen, the Netherlands (2015, June 18 - 2015, June 20). Krom, B.P. (2015). Organizer. Fall Meeting Section General and Molecular Microbiology, Royal Dutch Society for Microbiology: Utrecht, the Netherlands (2015, November 13). Raber-Durlacher, J.E. (2015). Organizing committee. NKI AVL, Orale complicaties bij patiënten die behandeld worden met chemotherapie en een stamceltransplantatie. AMC workshop om oral graft versus host disease: Amsterdam, the Netherlands (2016, June 22). Van der Veen, M.H. (2015). Organizer. Colgate young expert workshop on Biofilm models in oral health and disease: ACTA, Amsterdam, the Netherlands (2015, November 01 - 2015, November 02). Van Loveren, C., Crielaard, W. & Exterkate, R.A.M. (2015). Organizing committee. Symposium Future and Past of Preventive Dentistry: ACTA, Amsterdam, the Netherlands (2015, April 17).

Invited speakers at (inter)national scientific congresses or symposia Boutsioukis, C. (2015, June 04). Root canal irrigation: blending endodontics and fluid dynamics. Monterrey, Mexico, 2015 Annual meeting of the Mexican Endodontic Association. Boutsioukis, C. (2015, June 05). Irrigant extrusion during root canal irrigation. Monterrey, Mexico, 2015 Annual meeting of the Mexican Endodontic Association.

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Boutsioukis, C. (2015, June 26). 1. A critical appraisal of ultrasonic activation. 2. Irrigant extrusion during root canal irrigation. Toronto, Canada, 2015 Endodontic Alumni Day, Faculty of Dentistry, University of Toronto. Boutsioukis, C. (2015, August 29). Irrigation in minimally-shaped root canals. Banff, Canada, 51st Annual General Meeting, Canadian Academy of Endodontics 2015. Boutsioukis, C. (2015, November 14). Keynote on Root canal irrigation in Endodontics: 1. Irrigant delivery methods. 2. Irrigant activation methods. Brussels, Belgium, Cercle Universitaire Bruxellois d'Endodontie (CUBE). Boutsioukis, C. (2015, November 27). 1. Irrigant delivery methods. 2. Irrigant activation methods. 3. Irrigant extrusion during root canal irrigation. Vilnius, Lithuania, Endodontics 2015, Lithuanian Society of Endodontology. Brand, H.S. (2015, March 12). Saliva and wound healing. Boston, USA, 93rd General session IADR. Brandt, B.W. (2015, November 01). 6e. Bioinformatics for microbiome data analysis., Colgate Young expert workshop on Biofilm models in oral health and disease. ACTA, Amsterdam, the Netherlands. Brandt, B.W. (2015, October 15). Relation between salivary microbiome and host-related parameters in healthy adults. Antalya, Turkey, 47th Meeting of CED-IADR. Buijs, M.J. (2015, February 04). Methodology for determination of potentially available fluoride in toothpastes. Frankfurt, Germany, ORCA Workshop. Crielaard, W. (2015, April 16). Oral health. Brussels, Belgium, International Life Science Institute. Crielaard, W. (2015, December 03). The human microbiome and antibiotics used in dental clinics. Guangzhou, China, Symposium. De Vries, T.J. (2015, November 30). ACVR1 mutant periodontal ligament fibroblasts and their role in osteogenesis and osteoclastogenesis. Leiden, the Netherlands, International Lorentz Workshop. Hoogenkamp, M.A. (2015, November 01). Biofilm assay’s. Utrecht, the Netherlands, Colgate Young expert workshop on Biofilm models in oral health and disease. Hoogenkamp, M.A. (2015, November 01). 6e. Biofilm assay’s. Colgate Young expert workshop on Biofilm models in oral health and disease. ACTA, Amsterdam, the Netherlands. Keijser, B.J.F. (2015, September 14). A new oral health concept beyond the absence of disease. Cardiff, Wales, UK, British Society for Oral and Dental Research (BSODR) annual meeting. Keijser, B.J.F. (2015, May 18). Microbiome and immune responses: The maintenance of oral health. Utrecht, the Netherlands, RIVM symposium. Keijser, B.J.F. (2015, October 16). Resilience: A new oral health concept beyond the absence of disease. Antalya, Turkey, 47th Meeting CED-IADR. Keijser, B.J.F. (2015, March 17). The development of the infant oronasal microbiota. The Hague, the Netherlands, 4th Beneficial Microbes Conference. Keijser, B.J.F. (2015, December 10). The upper respiratory microbiome of infants - learnings from the MINOES cohort. Utrecht, the Netherlands, Eijkman Institute Seminar Series 2015 - Streptococcus pneumoniae and Bioinformatics. Krom, B.P. (2015, November 01). 6e. Fungi in the oral cavity. Colgate Young expert workshop on biofilm models in oral health and disease. ACTA, Amsterdam, the Netherlands. Krom, B.P. (2015, June 23). Fungus-bacterium interactions in the healthy oral cavity. Brno, Czech Republic, EUROBIOFILMS 2015, Symposium: Mixed species fungal and bacterial biofilm communities. University Campus, Masaryk University. Krom, B.P. (2015, September 04). Fungus-bacterium interactions: an oral perspective. Antwerpen, Belgium, 3rd Workshop on bacterial and fungal biofilms. Universiteit Antwerpen. Krom, B.P. (2015, May 16). Human fungal pathogens. La Colle-sur-Loup, France, 6th FEBS Advanced lecture course, HFP2015. Loos, B.G. (2015, March 27). Een gezonde mond is goed voor de cardiovasculaire patiënt. Soestduinen, the Netherlands, Voorjaarscongres Vereniging van Orthodontisten,. Loos, B.G. (2015, August 29). Gingivitis, periodontitis, peri-implantitis. Shanghai, China, Clinical symposium Periodontal health is the foundation to oral health and systemic health, Philips Oral Healthcare China. Loos, B.G. (2015, October 14). Immunobiology of the healthy periodontium. Antalya, Turkey, Symposium Resilience: a new oral health concept beyond the absence of disease, the 47th Meeting Continental European Divison (CED, 6e International Association for Dental Research (IADR). Loos, B.G. (2015, June 03). Key factors in the aetiology of peri-implantitis. London, United Kingdom, European Federation of Periodontology (EFP), EuroPerio VIII.

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Loos, B.G. (2015, August 29). Oral disease and the need for public health approaches. Shanghai, China, Better gum health, better oral health, Philips Sonicare Advisory Board Meeting on China consensus on gingival health review meeting. Loos, B.G. (2015, March 21). Oral infections are risk factors for general health. School of Dental Medicine University of Zagreb, Croatia, 1st International Congress. Loos, B.G. (2015, May 13). Oral infections are risk factors for general health. School of Dental Medicine University of Zagreb, Croatia, Student Symposium, e-lecture. Loos, B.G. (2015, February 06). Parodontitis en algemene gezondheid. Rai, Amsterdam, the Netherlands, Congres Paro 2015. Loos, B.G. (2015, August 21). Periodontitis and its associations. Dubrovnik, Croatia, European Dental Student Association (EDSA) Summer School 2015. Nicu, E.A. (2015, November 02). Host-pathogens interactions: the role of polymorphonuclear neutrophilic granulocytes in the oral cavity. ACTA, Amsterdam, the Netherlands, Symposium Young Expert workshop Biofilm models in oral health and disease. Raber-Durlacher, J.E. (2015, June 25). Bacteremia associated with periodontal and dental infections in immunocompromised cancer patients. Copenhagen, Denmark, ISOO CE Course MASCC/ISOO Annual Meeting. Rozema, F.R. (2015, October 26). International OMS data registry. Melbourne, Australia, ICOMS. Slot, D.E. (2015, June 03). International journal of dental hygiene research. London, United Kingdom, Symposium EuroPerio8. Slot, D.E. (2015, June 04). What can the patient do at home? London, United Kingdom, Hypersensitivity symposium EuroPerio8. Smeele, L.E. (2015, November 27). Towards virtual therapy for cancer of the head and neck. London, UK, BAOMS & IAOO - Controversies in the management of cancer and precancer of the oral cavity. Van der Heijden, G.J.M.G. (2015, March 12). Using dashboards to leverage improvements in oral health prevention. Boston, USA, IADR symposium: Extracting value from big data in oral health care services. Van der Veen, M.H. (2015, November 01). 6e. From plaque to biofilm. Colgate Young expert workshop on biofilm models in oral health and disease. ACTA, Amsterdam, the Netherlands. Van der Waal, I. (2015, May 22). Diseases of the jaws; diagnosis and management. Parma, Italy, Postgraduate course University of Parma. Van der Waal, I. (2015, June 26). Leukoplakia; some diagnostic aspects. Copenhagen, Denmark, International Society of Oral Oncology. Van der Waal, I. (2015, January 23). Lichen planus and lichenoid lesions; diagnosis and management. Granada, Spain, Oral Cancer meeting. Van der Waal, I. (2015, October 22). Odontogenic cysts; an overview with emphasis on the histological aspects. Gent, Belgium, Belgische Pathologen Week. Van der Waal, I. (2015, April 17). Oral lichen planus; diagnosis and management. Izmir, Turkye, Congres Oral diagnosis and Maxillofacial Radiology. Van der Weijden, G.A. (2015, June 04). Effective plaque control, mechanical plaque control. London, United Kingdom, EuroPerio8. Van der Weijden, G.A. (2015, June 03). Evidence-based prevention and behavior. The importance of prevention of gingivitis (for preventing periodontitis). London, United Kingdom, EuroPerio8. Van der Weijden, G.A. (2015, January 30). Nazorg bij implantaten. Antwerpen, Belgium, Dentmerk jubileum event. Van Loveren, C. (2015, February 04). Methodology for determination of potentially available fluoride in toothpastes. Frankfurt, Germany, ORCA Workshop. Van Strijp, A.J.P. (2015, November 03). Non Restorative Caries Treatment (NRCT). A useful treatment concept in pediatric dentistry. Kyrenia, Northern Cyprus, 22nd Congress of Turkish Society of Pedodontics. Veerman, E.C.I. (2015, October 15). Role of salivary mucins in the maintenance of microbial ecology of the oral cavity. Antalya, Turkey, 47th Meeting of CED-IADR 15-17- October. Zaura, E. (2015, April 20). On the mother-newborn microbiome connection. Berlin, Germany, Symposium. Emerging trends in oral healthcare. Zaura, E. (2015, November 19). Oral microbiome and general health. London, UK, European Congress for The Human Microbiome. Zaura, E. (2015, March 17). Potential role of arginine as prebiotics for the healthy oral ecosystem. The Hague, the Netherlands, Beneficial Microbes Conference.

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Zaura, E. (2015, October 15). The normal oral microbiome at health. Antalya, Turkey, Resilience: A new oral health concept beyond the absence of disease. 47th Meeting of CED-IADR. Zaura, E. (2015, November 01). The role of the microbiome in health. ACTA, Amsterdam, the Netherlands, Colgate Young expert workshop on Biofilm models in oral health and disease. Zaura, E. (2015, October 16). Towards understanding oral health. Antalya, Turkey, CED-IADR Colgate sponsored symposium. 47th Meeting of CED-IADR. Zaura, E. (2015, April 17). Towards understanding oral health. Amsterdam, the Netherlands, Symposium. Past and future of preventive dentistry.

Other (inter)national scientific functions Bolscher, J.G.M.: Advisory Board - Chiang Mai University Journal of Natural Sciences, 2013-heden. Brand, H.S.: President-Elect - Salivary Research Group, International Association of Dental Research (IADR). Crielaard, W.: Board member - Oral Microbiology and Immunology Group, British Society for Oral and and Dental Research. Crielaard, W.: Visiting professor - Oral BioSciences, Hong Kong University, Hong Kong, China. Crielaard, W.: Visiting professor - Oral Microbiology School of Stomatology, Sun Yat Sen University, Guangzhou, China. Deng, D.M.: Coordinator - International Summer camp for ACTA students, Chengdu, Sichuan, China July 3-17. Deng, D.M.: Guest professor - Oral Microbiology, School of Stomatology, Sun Yat Sen University, Guangzhou, China. De Soet, J.J.: Member working group to develop new guidelines for Infection Prevention in dentistry for the NMT - Nederlandse Vereniging voor Medische Microbiologie. September 2013-2015. De Soet, J.J.: Treasurer - Stichting Orale Biologie. Gorter, R.C.: Executive board member - Association for Dental Education in Europe (ADEE), since 2013. Gorter, R.C.: Member - Platform for better oral health in Europe. Laine, M.L.: Member - Decentralized selection of dentals students committee ACTA. Laine, M.L.: Member - Doctoral Education Committee ACTA (DECA). Laine, M.L.: Corresponding member - Finnish Dental Society Appolonia. Laine, M.L.: Member - MSc-Peridontology exam commission, C. Delatola, ACTA. Laine, M.L.: Opponent - PhD thesis: Vitamin D and Periodontal Infection, G. Antonoglou, University of Oulu, Finland, 2 October 2015. Laine, M.L.: Member - Structure committee section Periodontology ACTA. Loos, B.G.: Member scientific committee - 47th Meeting Continental European Division (CED), International Association for Dental Research (IADR), October 14-17, Antalya, Turkey. Loos, B.G.: Board member - International Association for Dental Research (IADR), Continental European Division (CED). Loos, B.G.: Opponent - PhD thesis: Periodontitis and rheumatoid arthritis; a search for causality and role of Porphyromonas gingivalis. M. de Smit, Faculty of Medicine, Dept. of Dentistry and Oral Care, Rijksuniversiteit Groningen, the Netherlands, 4 November 2015. Loos, B.G. Member - IADR Young Investigator Awards Committee. Loos, B.G. Board member Society for the Advancement of Natural Sciences, Medicine and Surgery, University of Amsterdam, the Netherlands. Raber-Durlacher, J.E.: Member Expert Panel - Mucositis Research Workshop MASCC/ISOO Annual meeting, Copenhagen, Denmark 25-27 June 2015. Slot, D.E.: Member - Global Dental Hygiene Advisory board. Slot, D.E.: Abstract reviewer - IADR Oral Health Group.

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Slot, D.E.: Member lustrum commissie 2016 - Nederlandse Vereniging voor Parodontologie (NVvP). Slot, D.E.: Member commissie richtlijn parodontale behandeling in de algemene praktijk - Nederlandse Vereniging voor Parodontologie (NVvP). Slot, D.E.: Member congres commissie - Nederlandse Vereniging voor Parodontologie (NVvP). Van der Veen, M.H.: Honorary lecturer - University of Liverpool, UK. Van der Veen, M.H.: Secretary general - European Organization for Caries Research (ORCA). Van der Waal, I.: Peer reviewer - Cancer Research UK; Peer review request on A phase III randomised trial of Lugol's Iodine in surgical management of epithelial dysplasia in the oral cavity and oropharynx. Van der Waal, I.: International expert - Evaluation of the thesis: Squamous cell carcinoma of the tongue by Nicola Sgaramella (University of Umea), April 2015. Van der Waal, S.V.: Member scientific committee - Nederlandse Vereniging voor Endodontologie (NVvE). Van der Weijden, G.A.: Member - Benoemingscommissie KIMO. Van der Weijden, G.A.: Member - EMEA Oral Health Advisory Council. Van der Weijden, G.A.: Board member - Nederlandse Vereniging voor Parodontologie (NVvP). Van der Weijden, G.A.: Chairman commissie richtlijn parodontale behandeling in de algemene praktijk - Nederlandse Vereniging voor Parodontologie (NVvP). Van der Weijden, G.A.: Member stuurgroep 2, kamer mondzorg - NMT & ACTA. Van der Weijden, G.A.: Chairman commissie richtlijn Peri-Implantitis - NVOI/NVvP. Van Diermen, D.E.: Chair - Special Interest Group Medically Complex Patients, Association Dental Education Europe, since August 2014. Van Diermen, D.E.: Consultant - World Workshops American Academy Oral Medicine, San Diego 2014-2015. Van Loveren, C.: Member advisory board - Sugar Bureau UK. Van Loveren, C.: Member advisory board - Tooth Friendly Society. Van Loveren, C.: Voorzitter Adviescollege preventie - Mond en Tandziekten Ivoren Kruis. Zaura, E.: Visiting professor - Oral Microbiology and Preventive Dentistry, Faculty of Medicine, University of Latvia, Riga, Latvia.

Supervisor of an external PhD student Milstein, D.M.J. (2015). Co-supervisor of external PhD student J.F. Ashruf with thesis: Myocardial microcirculation and mitochondrial energetics in the isolated rat heart. Supervisors: prof.dr. C. Ince; co- supervisors: dr. D.M.J. Milstein, dr. C.J. Zuurbier - Universiteit van Amsterdam (152 pag.), 4-11-2015.

Collaborations - ACHMEA BV NL, B Egberts, EU H2020 ADVOCATE project partner. - Aridhia Informatics Ltd UK, R. Bryce, K. O’Hanlon, EU H2020 ADVOCATE project partner. - Ben Gurion University of the Negev, Beer Sheva, Israel, Dr. M. Meijler. - Brigham and Womens’s Hospital, Harvard University, Boston. MA, USA Professor S.T. Sonis and Dr. N.S. Treister. - Carolinas Medical Center, Dept. of Oral Medicine, Michael Brennan. - Catharina Ziekenhuis, Eindhoven, the Netherlands. Department of Oral and Maxillofacial Surgery: Pijpe J. - Cedars-Sinai Medical Center, Los Angeles, CA, Professor J.B. Epstein. - Center for Advanced Research in Public Health, Valencia, Spain, Dr. Alex Mira. - Centre for Integrative Bioinformatics (IBIVU), VU Amsterdam, Prof. J. Heringa, Dr. S. Abeln. - Cipto Mangukusumo Hospital, Jakarta, Republic of Indonesia. - DeCare Dental Insurance Ireland IE, M Walsh, EU H2020 ADVOCATE project partner. - Department of Endodontics, School of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. - Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.

45 Annual Research Report 2015

- Department of Microbial Diseases, UCL Eastman Dental Institute, London, United Kingdom. - Department of Otorhinolaryngology, VUmc - Department of Pathology, VUmc - Department of Periodontology, Endodontology and Cariology, University of Basel, Basel, Switzerland. - Division of Otolaryngology and Head and Neck Surgery, City of Hope, Duarte, CA, USA, Joel B Epstein. - Faculty of Archeology, Leiden University, Drs. K.A. Ziesemer, prof.dr. Corinne Hofman. - Genetics and Genomic Medicine Programme, UCL Institute of Child Health, London, United Kingdom. - Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, United Kingdom. - Harvard University Brigham and Women’s Hospital, Boston MA, USA Dept. of Oral Medicine Stephen Sonis. - Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy, Paolo Bossi. - Helperby Therapeutics Limited, London, United Kingdom. - Keele University, UK, Neal Maskrey, EU H2020 ADVOCATE project partner. - Kindertandheelkundepraktijk Bambodino, Rotterdam, the Netherlands, Gambon DL. - Kobenhavns Universitet DK, Dental School, Prof L. Cristensen, EU H2020 ADVOCATE project partner. - Malmö University, Sweden, Faculty of Health and Society, Biomedical Sciences: Sotres J. Faculty of Odontology, Prosthetic Dentistry: Lindh L, Arnebrandt T. - Massachusetts General Hospital/Harvard University, Dept. of OMFS. - Molecular Cell Physiology, FALW, VU, Dr. Wilfred Röling. - National Institutes of Health Washington DC. - NHS England UK, C Bridgeman, EU H2020 ADVOCATE project partner. - Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. Department of Oral and Maxillofacial Surgery: Gilijamse M. - Radboud UMC, Radboud University Nijmegen, Professor N.M.A. Blijlevens and Professor M.C.D.N.J.M. Huysmans. - Regional Center for Biomedical Research, Albacete Science & Technology Park, University of Castilla-La Mancha, Albacete, Spanje, Dr. P.W.J. de Groot. - Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, The Netherlands. - School of Stomatology, Sun Yat Sen University, Guangzhou, China, Prof. Wei X. - Semmelweis Egyetem Hu, Dental School, Prof M Madlena, EU H2020 ADVOCATE project partner. - SpectrumK GmbH DE, J Bentz, EU H2020 ADVOCATE project partner. - Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. - Swammerdam Institute for Life Sciences, UvA, Dr. Joost Teixeira de Matos. - The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands, MSB Group: Imangaliyev S, Tsivtsivadse E. - Universitaetsklinikum Heidelberg DE, Dental School, Prof S Listl, EU H2020 ADVOCATE project partner. - Universitat International Catalunya, Barcelona, Spain. - Universiteit Zurich, MKG. - University College Cork, National University Of Ireland, CORK IE, Dental School, Prof N Woods, EU H2020 ADVOCATE project partner. - University of Gothenburg Sweden Dept. Oral Medicine Inger von Bultzinslowen. - University Of Leeds, UK, Dental school, Prof H Whelton, Prof G Douglas, EU H2020 ADVOCATE project partner. - University of Maryland Dental School, Baltimore, USA, Dr. M.A. Jabra-Rizk. - University of Nagasaki, Japan, Dr. Y. Iijima. - University of Washington Medical Center, Seattle. Dept. of OMSF. - VU University Medical Center, Amsterdam, the Netherlands, Department of Oral and Maxillofacial Surgery/Oral Pathology: Baart JA, Ruslin M, Wolff J, Boffano P, Forouzanfar T, Karagozoglu KH. - VUmc, Medische Microbiologie, A.E. Budding, B.B. Wintermans. - Weill Cornell Medical College, Dept. of Medicine New York, NY, USA Andrei Barasch. - West China School of Stomatology, Sichuan University, China, Prof. Li J., Dr. Cheng L. - A. Mithoefer. Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Hans Knöll Straße 8, D-07745, Jena, Germany. - BENECOMO, Flemish Netherlands Geriatric Oral Research Group and Zorgaccent, Amersfoort, the Netherlands, Dr. G.J. van der Putten

46 Academic Centre for Dentistry Amsterdam

- Catharina Ziekenhuis, Eindhoven, the Netherlands, Department of Oral and Maxillofacial Surgery: Pijpe J. - Clinic for Carolinas Health Care System Charlotte, North Carolina, USA Professor Michael Brennan - Clinic for Conservative Dentistry and Periodontology, Uniklinikum Schleswig-Holstein-Campus Kiel-Germany Christof Doerfer - College of Dentistry, New York University, USA, Richard Niederman - Common Wealth University, Virginia, Prof.dr. H.A. Schenkein - Conservative Dentistry and Periodontology, Uniklinikum Schleswig-Holstein-Campus, Kiel, Germany, Karim M. Fawzy El-Sayed - Department of Paediatric Dentistry, Faculty of Dentistry, Near East University, Nicosia, Cyprus. - Department of Periodontics, School of Dentistry, University of Missouri-Kansas City, USA, Charles Cobb - Dr. Annica Almstahl. Dept. of Oral Microbiology and Immunology, Sahlgrenska Academy, Institute of Odontology, University of Gothenburg, Sweden. - Erasmus Medisch Centrum, Dr. M. van Zelm - G. Koop. Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CL, the Netherlands. - H.P. Haagsman, E. Veldhuizen, A. van Dijk. Division of Molecular Host Defence, Faculty of Veterinary Medicine, Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, the Netherlands. - Health Science Research Center, Indiana University-Purdue University, Fort Wayne, IN, USA, Mark Putt - Interleukin Genetics, USA: Prof.dr. K. Kornman - J. Sotres, L. Lindh, T. Arnebrant. Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden. - Khon Kaen University, Thailand, Dept. of Oral Diagnosis. P. Chaiyarit, and S. Taweechaisupapong. - Kindertandheelkundepraktijk Bambodino, Rotterdam, the Netherlands, Gambon DL. - M. Zourob. Department of Chemistry, Alfasal University , Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Kingdom of Saudi Arabia. - Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands, Department of Oral and Maxillofacial Surgery: Gilijamse M. - Oral Diagnostic Sciences University of Adelaide, Adelaide Australia Professor Richard Logan - Prof.dr. Yvette van Kooyk. Dept. Molecular Cell Biology and Immunology, VU Medical Center. - Radboud University Medical Center Prof.dr. W.H. van Palenstein Helderman and Prof.dr Nicole Blijlevens - T. van Werven. Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CL, the Netherlands; University Farm Animal Practice, 3481 LZ Harmelen, the Netherlands. - The Netherlands Organization for Applied Scientific Research (TNO), Zeist, the Netherlands MSB Group: Imangaliyev S, Tsivtsivadse E. - Tigran, Malmö, Sweden, U. Lundgren - TNO, Zeist, Dr. E. Tsivtsivadze and Prof.dr.ir. B.J.F. Keijser, Preventive dentistry, ACTA-TNO Zeist - Université François Rabelais, France, Pathologies Respiratoires: protéolyse et aérosolthérapie, F. Lecaille. - Universiteit van Amsterdam, AMC, Dept. of Clinical Chemistry - Universiteit van Groningen, Dept. of Periodontology - University Federico II, Naples, Italy. Department of Periodontology, Andrea Blasi - University of Amsterdam, Core facility Cellular Imaging / LCAM-AMC. J. Stap. - University of Bandung, Indonesia, Amaliya - University of Bonn, Dept. of Periodontology, Prof.dr. S. Jepsen - University of Cairo, Oral Medicine and Periodontology Department- Faculty of Dentistry- Egypt Karim M. Fawzy El-Sayed - University of California Los Angeles, USA, School of Dentistry and Dental Research Institute. D.T.W. Wong. - University of Gothenburg Sweden Professor Inger von Bültzingslöwen - University of Kiel, Germany, Dept. of Gastro‐Enterology, Prof.dr. S. Schreiber - University of Kiel, Germany, Institute for Clinical Molecular Biology, Dr. A. Scheafer - University of Kristianstad, Sweden, Prof.dr. S. Renvert - University of Madrid, Spain, Prof.dr. M. Sanz - University of Malaya, Malaysia, Faculty of Dentistry, Dr. Rathna Devi Vaithilingam - University of Milan, Italy, Unit of Periodontology, Giulio Rasperini - University of Patras, Greece, Prof.dr. T. Bountis - University of Rome, Italy, Prof.dr. Pilloni - University of Wageningen, The Netherlands, Dr. S. Boesveldt

47 Annual Research Report 2015

- VU University Medical Center, Amsterdam, the Netherlands, Department of Oral and Maxillofacial Surgery/Oral Pathology: Baart JA, Ruslin M, Wolff J, Boffano P, Forouzanfar T, Karagozoglu KH. - W. van Wamel, W. Kaman-van Zanten, Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, the Netherlands

Current PhD projects Akveld NAE. Tailor-made transparency-intervention for dentists: using registry feedback to improve effectiveness of caries related oral healthcare. Supervisor: prof.dr. J.J.M. Bruers; co-supervisor: prof.dr. G.J.M.G. van der Heijden, start: 2015. Baâdoudi, F. Horizon 2020 (EU) ADVOCATE field studies. Supervisor: prof.dr. G.J.M.G. van der Heijden, co- supervisor: dr. D. Duijster, start: 2015. Baaij A. Curricular changes in undergraduate dental education. Supervisor: prof.dr. J.F.M. Roeters; co- supervisor: dr. A.R. Özok, start: 2014. Beerens MW. Aspects in the prevention of caries in patients undergoing orthodontic treatment with multi- bracket fixed appliances. Supervisor: prof.dr. J.M. ten Cate; co-supervisor: dr.ir. M.H. van der Veen, start: 2009. Boink, MA. Histatin peptides for treatment of chronic wounds. Supervisors: prof.dr. E.C.I. Veerman & prof.dr. S. Gibbs; co-supervisor: dr. J.G.M. Bolscher, start: November 2010. Broers DLM. Experienced-based dentistry in individuals with physical and/or mental limitations. Supervisor: prof.dr. A. de Jongh; co-supervisor: prof.dr. G.J.M.G. van der Heijden, start: 2012. Cao Y. Different osteoclasts and their response to cytokines. Supervisor: prof.dr. V. Everts, co-supervisor: dr.ir. T.J. de Vries, start 2014. De Jong BG. Local and systemic antibody responses for maintaining gingival health. Supervisors: prof.dr. W. Crielaard & prof.dr. B.G. Loos; co-supervisor: dr. M.C. van Zelm, start: April 2012. De Jong-Lenters M. Gebitsgezondheid van kinderen in relatie tot het gezin. Supervisor: prof.dr. G.H.W. Verrips & prof.dr. C. van Loveren; co-supervisor: dr. A.A. Schuller, start: June 2012. De Roos CJAM. Treatment of children following a potential traumatic incident. Supervisors: prof.dr. A. de Jongh & prof.dr. P.M.G. Emmelkamp, start: 2008. De Vries M.W. De wisselwerking tussen artritis en orofaciale weefsels. Supervisors: prof.dr. F. Lobbezoo & prof.dr. B.G. Loos, co-supervisors: prof.dr. D. van Schaardenburg & prof.dr. W. Crielaard, start: November 2015. Dekker, H. Peri-implantitis, implant loss and osteoradionecrosis in oral cancer patients. Supervisors: prof.dr. E.A.J.M. Schulten, prof.dr. C.M. ten Bruggenkate & prof.dr. E. Bloemena; co-supervisor: dr. N. Bravenboer, start: 2010. Donders HCM. The effects of periodontal therapy on systemic health of patients with cardiovascular disease. Supervisors: prof.dr. J. de Lange & prof.dr. B.G. Loos; co-supervisor: dr. A.W.J. van 't Hof, start: January 2011. Elkerbout TA. Oral hygiene. Supervisor: prof.dr. G.A. van der Weijden, co-supervisor: dr. D.E. Slot, start: May 2015. Esposito SA. Supervisor: prof.dr. P.R. Wesselink; co-supervisor: dr. H. Shemesh & prof. E. Cotti, start: 2015. Fernandez y Mostajo M. Novel methods for preventing and treating polymicrobial biofilm infections in the oral cavity. Supervisors: prof.dr. W. Crielaard, prof.dr. G.A. van der Weijden & prof.dr. W. Beertsen; co- supervisor: dr. E. Zaura, start: June 2011. Geurs N.C. Socket preservation after extraction for implant dentistry. Supervisors: prof.dr. B.G. Loos & prof.dr. U. van der Velden, start: 2010. Gunput, STG. The effect of saliva on the complement system. Supervisor: prof.dr. E.C.I. Veerman; co- supervisor: dr. A.J.M. Ligtenberg, start: January 2012. Hansenova Manaskova, S. Sortase as target for antimicrobial peptides. Supervisor: prof.dr. E.C.I. Veerman; co- supervisor: dr. F.J. Bikker, start: November 2010. Haverman T.M. Oral mucositis. Supervisors: prof.dr. F.R Rozema & prof.dr. J. de Lange; co-supervisor: dr. J.E. Raber-Durlacher. Start: January 2013. Helmers R. Hyperbaric oxygen therapy and micro vascularisation. Supervisor: prof.dr. J. de Lange; co- supervisor: dr. D.M.J. Milstein, start: September 2011. Hennequin-Hoenderdos NL. Piercings and abrasion. Supervisor: prof.dr. G.A. van der Weijden, co-supervisor: dr. D.E. Slot, start May 2015.

48 Academic Centre for Dentistry Amsterdam

Hertog, D. Treatment of ameloblastomas. Supervisor: prof.dr. E.A.J.M. Schulten; co-supervisor: prof.dr. I. van der Waal, start: September 2009. Hol MLF. Skull growth in oncological treatments in childhood. Supervisors: prof.dr. L.E. Smeele & prof.dr. A.G Becking, start: January 2013. Hummel GI. Van meten naar verbeteren? Hoe uitkomstindicatoren de behandelaanpak van de tandarts en de cariësincidentie bij de jeugd beïnvloeden. Supervisors: prof. dr. G.J.M.G. van der Heijden & prof. dr. J.J.M. Bruers, start: 2015. Imangaliyev S. Novel strategies to promote oral health. Supervisor: prof.dr. W. Crielaard; co-supervisor: prof.dr.ir. B.J.F. Keijser, start: September 2012. Janus MM. Microbial interactions in oral biofilms. Supervisor: prof.dr. W. Crielaard; co-supervisor: dr. B.P. Krom, start: June 2012. Koopman JE. Ecological dynamics of oral microbial communities. Supervisors: prof.dr.ir. B.J.F. Keijser & prof.dr. W. Crielaard; co-supervisor: dr. E. Zaura, start: April 2010. Liao Y. Fluoride resistance of Streptococcus mutans. Supervisors: prof.dr. C. van Loveren & prof.dr. W. Crielaard; co-supervisors: dr. B.W. Brandt & dr. D. Deng, start: 2014. Louropoulou A. Maintenance of peri-implant health, the evidence and guideline. Supervisor: prof.dr. G.A. van der Weijden, start: 2010. Matse, JH. The diagnostic role of mucin expression in tissue and saliva in patients with salivary gland tumors. Supervisors: prof.dr. E. Bloemena & prof.dr. E.C.I. Veerman; co-supervisor: dr. J.G.M. Bolscher, start: September 2008. May A. Bioinformatic analysis for oral metagenomics. Supervisors: prof.dr. W. Crielaard & prof.dr. J. Heringa; co-supervisors: dr. B.W. Brandt & dr. S. Abeln, start: August 2012. Mevissen-Renckens EHM. EMDR as a treatment of individuals with intellectual disabilities. Supervisor: prof.dr. A. de Jongh; co-supervisor: prof.dr. R. Didden, start: 2010. Moghimi, M. Head and neck infection. Supervisors: prof.dr. T. Forouzanfar & prof.dr. E.A.J.M. Schulten, start: 2011. Moinzadeh, AT. Quality assessment of root canal obturation. Supervisor: prof.dr. P.R. Wesselink; co- supervisor: dr. H. Shemesh, start: 2012. Neelakantan, P. Influence of irrigation solution on the root canal filling. Supervisor: prof.dr. P.R. Wesselink; co- supervisor: dr. H. Shemesh, start: 2012. Papantonopoulos GH. Mathematical modeling of periodontitis. Supervisor: prof.dr. B.G. Loos, start: 2012. Persoon IF. Molecular ecology and novel treatments in endodontic infections. Supervisor: prof.dr. W. Crielaard; co-supervisor: dr. A.R. Özok, start: 2010. Prodan, A. Saliva and oral health. Supervisors: prof. dr. E.C.I. Veerman; co-supervisors: dr. H.S. Brand & prof.dr.ir. B.J.F. Keijser, start: September 2012. Rademacher WMH. Oral complications in oncological treatment. Supervisors: prof.dr. F.R. Rozema & prof.dr. J. de Lange; co-supervisor: dr. D.E. van Diermen. Start: August 2013. Raghav K. The use of virtual reality technology for the treatment of dental fears. Supervisor: prof.dr. A. de Jongh, start: 2013. Rijkschroeff P. The oral polymorphonuclear neutrophils Supervisor: prof.dr. B.G. Loos, co-supervisor: dr. E.A. Nicu, start: January 2013. Roseboom HJ. Oral mucositis and graft versus host disease (GVHD) after stem cell transplant: the role of different host factors and oral pathogens. Supervisors: prof.dr. F.R. Rozema & prof.dr. W. Crielaard; co- supervisors: dr. D.M. Deng & dr. A.M.G.A. Laheij, start: 2015. Sälzer SA. Dentifrices and Oral Hygiene. Supervisors: prof.dr. G.A. van der Weijden & prof.dr. C.E. Doerfer, co- supervisor: dr. D.E. Slot, start: May 2015. Schreuder WH. Treatment options in central giant cell granuloma. Supervisor: prof.dr. J. de Lange; co- supervisors: dr. H. van den Berg & dr. J.A.M. Bramer, start: January 2010. Shang L. Host and microbe interaction. Supervisors: prof.dr. C. van Loveren & prof.dr. S. Gibbs; co-supervisors: dr. D.M. Deng & prof.dr. W. Crielaard, start: 2015. Sijbrandij, T. Application of antimicrobial peptides as anti-warfare therapeutics. Supervisors: prof. dr. E.C.I. Veerman; co-supervisors: dr. F.J. Bikker & dr. A.J.M. Ligtenberg,start: March 2010. Sprangers SL. Osteoclasts and their precursors. Supervisor: prof.dr. V. Everts, co-supervisor: dr.ir. T.J. de Vries, start: 2014. Steenen SA. The effects of propranolol on fear of wisdom tooth removal: A randomized, placebo-controlled. Double-blind parallel design trail. Supervisors: prof. dr. A. de Jongh & prof. dr. J. de Lange, start: 2013.

49 Annual Research Report 2015

Tabeian H. Arthritis models for the Temporo Mandibular Joint. Supervisors: prof.dr. V. Everts & prof.dr. F. Lobbezoo; co-supervisors: dr. A.D. Bakker & dr.ir. T.J. de Vries, start: 2012. Tan, CWX. Oral manifestations of inflammatory Bowel disease. Supervisor: prof.dr. T. Forouzanfar; co- supervisor: dr. H.S. Brand, start: September 2012. Teeuw W.J. Relationships between periodontitis an general health: focus on diabetes and cardiovascular disease. Supervisor: prof.dr. B.G. Loos, start: October 2010. Ten Harkel B. Multinucleated giant cells versus osteoclasts. Supervisor: prof.dr. V. Everts; co-supervisor: dr.ir. T.J. de Vries, start: December 2011. Valstar MH. Controversies in epidemiology, diagnosis and treatment of salivary gland tumors. Supervisors: prof.dr. L.E. Smeele & prof.dr. A.J.M. Balm, start: May 2013. Van der Kaaij NCW. Efficacy of fluoride rinse in the prevention of caries in patients undergoing orthodontic treatment with multi-bracket fixed appliances. Supervisor: prof.dr. J.M. ten Cate; co-supervisors: dr.ir. M.H. van der Veen & dr. E. Zaura, start: 2009. Van der Sluijs E. Mouthrinses and Bad Breath. Supervisor: prof.dr. G.A. van der Weijden, co-supervisor: dr. D.E. Slot, start: May 2015. Van der Waal SV. Novel strategies for endodontic treatments. Supervisors: prof.dr. P.R. Wesselink & prof.dr. W. Crielaard; co-supervisor: dr. J.J. de Soet, start 2009. Van der Wouden P. Agendering van onderzoek in de mondzorg: De kennisagenda mondgezondheid. Supervisor: prof.dr. G.J.M.G. van der Heijden; co-supervisor: dr. H. Shemesh, start: May 2015. Van der Zande MM. Digital dentistry in practice: On dentists’ interaction with technological transformation. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. R.C. Gorter, start: February 2012. Van Dijk, IA. How histatins enhances wound closure: structural and cellular aspects. Supervisor: prof.dr. E.C.I. Veerman; co-supervisor: dr. J.G.M. Bolscher, start: February 2011. Van Dijk S. Functional consequences of oral tongue carcinoma. Supervisors: prof.dr. L.E. Smeele & prof.dr. A.J.M. Balm, start: january 2013. Van Houtem CMMH. ADRA2B polymorphism as a putative biomarker for the acquisition of anxiety based on inadequate storage of emotional memories. Supervisor: prof.dr. A. de Jongh; co-supervisor: dr. A.J. van Wijk, start: 2009. Van Vliet NI. The necessity of stabilization in the treatment of complex PTSD. Supervisors: prof.dr. A. de Jongh & prof.dr. A. van Minnen, start: 2015. Verhulst J.L.M. The implementation of oral care in diabetic patients. Supervisor: prof.dr. B.G. Loos, co- supervisor: dr. V.E. Gerdes, start: January 2015. Vogels MPJM. Supervisor: prof.dr. J. de Lange; co-supervisor: H. Shemesh, start: 2015. Volgenant CMC. Red fluorescence in dental plaque. Supervisor: prof.dr. J.M. ten Cate; co-supervisor: dr.ir. M.H. van der Veen, start: 2010. Zecha JAEM. Effect van lage intensiteit laser behandeling (LLLT) op bestralingsmucositis van het mondslijmvlies. Supervisors: prof.dr. L.E. Smeele & prof.dr. J. de Lange; co-supervisor: dr. J.E. Durlacher, start: January 2013. Zemouri C. Hoe kunnen we de transmissie van potentieel schadelijke micro-organismen binnen de tandheelkundige praktijk verminderen? Supervisor: prof.dr. W. Crielaard; co-supervisors: dr. J.J. de Soet & dr. A.M.G.A. Laheij, start: December 2015.

Societal impact Oral infections and oral cancer have a substantial impact on the society. Oral infectious diseases are the most frequent infections in the western society and have important consequences, both medically and economically. Head and neck squamous cell carcinomas (HNSCC) and specifically oral squamous cell carcinomas (OSCC) are the most prevalent forms of head and neck cancer. The general aim of the program is to understand the normal healthy oral cavity and to understand links with general health, to study oral innate immunity and susceptibility to caries and periodontal diseases, to study prevention and treatment options for the oral infectious and inflammatory processes and to study the epidemiology and pathegnesis of oral cancers, in particular in relation to good/poor oral health. In addition, attention is paid to social and psychological aspects of dental treatment, such as dental anxiety. Through education, a new generation of dentists and researchers in the Netherlands, Europe and the world are trained to implement a radical shift from mechanistically and (invasive) treatment oriented professionals to 21st century oral physicians focused on diagnosis and prevention of dental and of oral infections and maintenance of the quality of life. Over the last 5 years it has become increasingly clear that oral infections are

50 Academic Centre for Dentistry Amsterdam having negative impact on cardiovascular health, diabetic status and quality of life. The researchers in this theme focus on this aspect. The members of our priority area have had a relative large number of invitations to give lectures at dental congresses, and to educate the dental profession on fundamental understanding of oral health. Moreover, we experienced increased interest from newspapers, magazines and radio programs on the above subjects, in which we participated. The link oral health - general health is actively communicated by the researchers. Important for the dental profession and the general public, is the substantial number of published and accessible systematic reviews (and meta-analyses) on the various modes of prevention and oral hygiene measures. These contribute to clinical protocols for the dental profession and form the basis for evidence based dentistry. Ongoing clinical research on oral and head/neck cancer contributes to improved prevention, diagnosis and treatment of relevant patient groups. New plans are developed to bring together knowledge on oral microbiomes and salivary innate immune peptides with oral cancer diagnosis and pathophysiology. The program has strong links with all players in the oral care industry; this not only results in “contract research”, but also in industrial co-funding of grants (STW) and has led to participation of ACTA in the Top Institute Food and Nutrition (TIFN), where the theme “Oral Health” has been initiated. In this theme, world players in the oral care industry, the chewing gum industry, flavour industry, food industry and (oral) care appliances industry collaborate with the University of Wageningen, TNO and ACTA. The societal impact of the research is evident from the impact on patient care and public dental health, and from collaborations with the industry, as is shown by for instance the grants obtained and the external reports. The societal impact of the clinical research contributes to improved prevention, diagnosis and treatment of relevant patient groups. The societal impact is evident from the items listed below.

I. Societal relevance for the dental professional in the Netherlands

Courses organized for Dutch dental and medical professionals Bizzarro, S. Parodontale chirurgie in de algemene praktijk. Acta-DE, Amsterdam, the Netherlands, 13 February 2015. Bizzarro, S. & Bussink, M. Paro workshop voor de Algemene - en Mondhygiëne praktijk. Acta-DE, Amsterdam, the Netherlands, 9 April 2015. Bloemena, E. Benecke nascholing: Oncologie in de tandheelkundige praktijk. Nascholing voor tandartsen en mondzorgkundigen, Amsterdam, 11 December 2015. Brand, H.S. Acute Medische Situaties in de Tandartspraktijk. 12 June 2015. PAOT-cursus, ACTA, Amsterdam. Brand, H.S. Acute Medical Situations in the dental office. 4 September 2015. Post graduate school, ACTA, Amsterdam. Brand, H.S. Acute Medische Situaties in de Tandartspraktijk. 6 November 2015. PAOT-cursus, Maastricht. Brand, H.S. Acute Medical Situations in the dental office. 2 December 2015. Department of orthodontics, ACTA, Amsterdam. Teeuw, W.J. Verwijzersavond. Moderator. Periodontic Clinic, ACTA, Amsterdam, the Netherlands, 14 October 2015. Van der Waal, I. Mondpathologie. Een nascholingscursus voor KNO-artsen en dermatologen. Amsterdam, 6 February 2015. Van der Waal, I. Mondziekten; een update voor tandartsen. Nascholingscursus voor tandartsen; voorjaar 2015. Samensteller van de cursus. Gepresenteerd door kaakchirurgen in 10 plaatsen in het land. Bohn Stafleu van Loghum, Houten, 2015. Van der Waal, I. Mondziekten; een update voor huisartsen. Nascholingscursus voor huisartsen; voorjaar 2015. Samensteller van de cursus. Gepresenteerd door kaakchirurgen in 2 plaatsen in het land. Bohn Stafleu van Loghum, Houten, 2015. Van der Waal, I. & Schulten, E.A.J.M. Nascholingscursus voor kaakchirurgen en pathologen. 3 en 4 September 2015, Amsterdam. Van Strijp, A.J.P. QP dag Kindertandheelkunde: rocket science of kinderspel. Lezing: Etiologie en pathogenese van cariës, 24 January & 11 April. Van Strijp, A.J.P. Wortelcariës en droge mond.QP Mondhygiëne; QP dag Mondzorg voor ouderen, 6 March. Van Strijp, A.J.P. Management van cariës en erosie. KNMT Afd. Utrecht Polderland, 20 November. Van Strijp, A.J.P. (19 November). Cariësdiagnostiek en minimaal invasieve behandelconcepten. Koninklijke Marine, Den Helder. (Nascholingscursus Tandheelkundige Dienst Kon. Marine).

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Lectures given during courses for Dutch dental and medical professionals A large number of lectures were given during courses for dentists, medical specialists and oral hygienists in the Netherlands by the following scientists: Bizzarro, S. Diabetes mellitus en mondgezondheid Iqual. KNMT, Arnhem, the Netherlands, 11 November 2015, Gilze, the Netherlands, 2 November 2015, Zwolle, the Netherlands, 29 October 2015. Bloemena, E. Cyto- en histopathologie van speekselkliertumoren; Mond- en Kaakziekten: een nascholingscursus voor kaakchirurgen en pathologen, 4-9-15, Trippenhuis, Amsterdam Bruers, J.J.M. (2015, October 03). Dossiervorming, een heet hangijzer! ACTA Dental Education (ADE). Symposium Regels, Risico's en Rumoer: de andere kant van de tandartspraktijk belicht. Symposium over regelgeving en handhaving inzake de tandartspraktijk. Amsterdam, the Netherlands. Crielaard, W. (13 & 20 June). Hygiëne en infectiepreventie: constant voortschrijdende inzichten. QP voor tandartsen. De Lange, J. Infecties in het Hoofd-Hals gebied. Voorjaarsvergadering NvVO 27/3. De Soet, J.J. (29 May). Infectiepreventie richtlijnen binnen de mondzorgpraktijk; boeien of boeiend? QP voor mondhygiënisten. De Soet, J.J. (13 & 20 June). Infectiepreventie richtlijnen binnen de mondzorgpraktijk; boeien of boeiend? QP voor tandartsen. De Visscher, J.G.A.M. Tumoren van de speekselklieren: diagnostiek en behandeling. Mond- en Kaakziekten: een nascholingscursus voor kaakchirurgen en pathologen. 4 September 2015, Amsterdam De Visscher, J.G.A.M. Herkennen van relevante afwijkingen in en rond de mond. Tandartsen en mondhygiënisten. 11 December 2015, Amsterdam Duijster, D. (2015, January 24). De rol van het gezin in de preventie van cariës bij kinderen. ACTA QP Kindertandheelkunde: Rocket science of kinderspel’? Amsterdam, the Netherlands. Eijkman, M.A.J. (2015, October 03). Enkele Casus. ACTA Dental Education (ADE). Symposium Regels, Risico's en Rumoer: de andere kant van de tandartspraktijk belicht. Symposium over regelgeving en handhaving inzake de tandartspraktijk. Amsterdam, the Netherlands. Hovens, R, van der Meij, E.H. Pijlman, M. & de Visscher, J.G.A.M. Mondafwijkingen: verwijzen naar de MKA- chirurg? BSL web tv. 19 May 2015, Hilversum. Karagozoglu K.H., De Visscher J.G.A.M. Mondziekten. Nascholing voor huisartsen. 26 March 2015 VUmc, Amsterdam. Krom, B. (29 May). Biofilms in tandheelkunde; vriend en vijand! QP voor mondhygiënisten. Krom, B. (13 & 20 June). Biofilms in tandheelkunde; vriend en vijand! QP voor tandartsen. Laheij, A.M.G.A. (29 May). Voorkomen van kruisbesmetting door het juist indelen en reinigen/desinfecteren van de praktijkruimtes. QP voor mondhygiënisten. Laheij, A.M.G.A. (13 & 20 June). Voorkomen van kruisbesmetting door het juist indelen en reinigen/desinfecteren van de praktijkruimtes. QP voor tandartsen. Loos, B.G. Parodontologie – Implantaat verlies – Peri-implantitis Masterclass Implantology, ACTA Dental Education, Amsterdam, the Netherlands, 15 April 2015. Loos, B.G. Een gezonde mond is goed voor de cardiovasculaire patiënt, NVvP-Philips Symposium De link tussen algemene gezondheid en parodontitis, Rijksmuseum, Amsterdam, the Netherlands, 13 March 2015. Loos, B.G. Een gezonde mond in een gezond lichaam. Rotterdamse Tandartsen Vereniging, Rotterdam, the Netherlands, 16 November 2015. Rademacher, W.M.H. Veilig werken in de tandheelkunde praktijk. QP, 28-01-15. Rozema, F.R. Veilig werken met medisch gecompromitteerde patiënten. Quality Practice, Utrecht, 31 January 2015. Rozema, F.R. Multifarmacie. Symposium Mondzorg voor Ouderen, Utrecht, 6 March 2015. Rozema, F.R. De mond openbaart. Vereniging Adviserend Geneeskundigen Zorgverzekeraars, Medisch Tandheelkundige Interactie, Zeist, 2015. Rozema, F.R. Implantologie bij medisch gecompromitteerde patiënten. Quality Practice, Amsterdam, 21 en 28 March 2015. Smeele, L.E. Kaakchirurgie in de algemene praktijk: mogelijkheden en beperkingen, ACTA Quality Practice: Utrecht; hoofd- hals oncologie, 31-1-2015. Smeele, L.E. Amsterdamse Hoofd- Hals Cursus: 1. Valkuilen bij het lymfklierbiopt in de hals. 2. Metastase van de onbekende primaire tumor, Amsterdam, 20-3-2015. Teeuw, W.J. Mondgezondheid & Diabetes mellitus. Regionale Organisatie Huisartsen Amsterdam, the Netherlands, 19 August 2015, 3 and 13 September 2015.

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Teeuw, W.J. De interactie. Parodontitis en welvaartsziekten?, Verwijzersavond paropraktijk Tilburg, the Netherlands, 25 June 2015. Teeuw, W.J. Diabetes mellitus & Mondgezondheid. Compact Clinics, Kliniek voor Parodontologie Amsterdam, the Netherlands, 20 May 2015. Teeuw, W.J. Parodontitis en algemene gezondheid: een link?, Verwijzersavond Ordentall, Rotterdam, the Netherlands, 4 March 2015. Van der Meij, E.H. & de Visscher, J.G.A.M. Mondziekten, Kaak- en Aangezichtschirurgie: een nascholingscursus voor huisartsen. 23 June 2015, Leeuwarden. Van der Waal, I. Leukoplakie; diagnostiek en behandeling. Nascholingscursus voor kaakchirurgen en pathologen. 3 & 4 September 2015, Amsterdam. Van der Waal, I. Lichen planus; diagnostiek en behandeling. Nascholingscursus voor kaakchirurgen en pathologen. 3 & 4 September 2015, Amsterdam. Van der Waal S.V. (11 December 2015). Wortelkanaaldesinfectie. Endodontische leergang van ACTA Dental Education. Van der Waal, S.V. (15 January 2015). Wortelkanaaldesinfectie anno 2015. Lezing voor tandartsenkring Alphen aan den Rijn. Van der Weijden, G.A. Workshop Hechten, ACTA Postgraduate opleiding, Amsterdam, the Netherlands, 26 February 2015. Van der Weijden, G.A. Seminar Paro-Restauratief, ACTA Postgraduate opleiding, Amsterdam, the Netherlands, 26 February 2015. Van der Weijden, G.A. Seminar Paro-Nazorg, ACTA Postgraduate opleiding, Amsterdam, the Netherlands, 26 March 2015. Van der Weijden, G.A. Workshop Air polisher, ACTA Postgraduate opleiding, Amsterdam, the Netherlands, 26 March 2015. Van der Weijden, G.A. Minisymposium Implantologie, ACTA Dept. of Implantology, Amsterdam, the Netherlands, 18 September 2015.

Organization of congresses and symposia for professionals in the Netherlands Danser, M.M. (2015). Organizing committee. Symposium: De link tussen algemene gezondheid en parodontitis. Nederlandse Vereniging voor Parodontologie (NVvP) & Philips Oral Healthcare: Rijksmuseum, Amsterdam, the Netherlands (2015, March 13). Rosema, N.A.M., Slot, D.E., Elkerbout, T.A., Hennequin-Hoenderdos, N.L., van der Sluijs, E. & van der Weijden, G.A. (2015). Organizing committee. Symposium: best evidence for dental hygiene practice: Middenbeemster, the Netherlands (2015, April 23). Slot, D.E. (2015). Organizing committee. Development congress program NVvP Perio up-to-date: Cinemec, Ede, the Netherlands (2015, November 27). Teeuw, W.J. (2015). Organizing committee. Parodontitis en een slechte gezondheid. Pre-congress NVM: Amersfoort, the Netherlands (2015, November 12). Teeuw, W.J. (2015). Organizing committee. Mondgezondheid versus diabetes mellitus: een link? Seminar NVM: Breukelen, the Netherlands (2015, November 16). Van der Weijden, G.A. (2015). Organizing committee. Paro 2015: Amsterdam, the Netherlands (2015, February 06).

Invited speakers at professional congresses or symposia in the Netherlands Bizzarro, S. (2015, November 27). Het effect van de behandeling van parodontitis zonder en met antibiotica; nieuwe inzichten. Ede, the Netherlands, NVvP congres Up to date, Cinemec. Bruers, J.J.M. (2015, September 19). Klinische praktijkrichtlijnen en onderzoek in de tandartspraktijk: het mes snijdt aan meer kanten! Utrecht, the Netherlands, Centrum voor Bijzondere Tandheelkunde (CBT), UMC Utrecht. Bruers, J.J.M. (2015, December 12). Meten van patiënttevredenheid in de tandartspraktijk. Utrecht, the Netherlands, Symposium Praktijkorganisatie Anno Nu, Medisch Ondernemen. Danser, M.M. (2015, February 06). Microbiologie wat weten we en wat kunnen we ermee? Amsterdam, the Netherlands, ANT congress.

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Duijster, D. (2015, November 06). Opvoeding en cariës: Family Matters! Oegstgeest, Leiden, the Netherlands, Nederlandse Vereniging voor Kindertandheelkunde, Najaarsvergadering NVvK – Voeding & Voorlichting: een hele mond vol. Duijster, D. (2015, November 13). Zoete ouders, gezond gebit? Oegstgeest, Leiden, the Netherlands, Nederlandse Vereniging voor Mondhygiënisten, NVM-najaarscongres: De jeugd niet vergeten. Duijster, D. (2015, November 21). Family Matters: De rol van het gezin in cariëspreventie bij kinderen uit sociaaleconomische en etnische risicogroepen. Amersfoort, the Netherlands, Het Ivoren Kruis congres: Succesvolle communicatie met uw patiënt. Eijkman, M.A.J. (2015, November 23). Juridische aspecten betreffende de implantologie. Den Haag/Leiden, the Netherlands, ITI Study Club. Elkerbout, T.A. (2015, October 08). Wetenschappelijk onderzoek: wat kun je ermee in de praktijk? Deventer, the Netherlands, NVM bijeenkomst. Laine, M.L. (2015, January 30). Biofilm op implantaatoppervlakken. Nazorg op implantaten. Amsterdam, the Netherlands, Oral Implantology QP ACTA. Laine, M.L. (2015, June 27). Halitose – adem met een luchtje. Kleine ongemakken. Amsterdam, the Netherlands, ACTA QP. Laine, M.L. (2015, March 27). Microbiologie van parodontale en peri-implantaire ontstekingen. Nazorg bij implantaten voor tandprothetici. Amsterdam, the Netherlands, Organisatie van Nederlandse Tandprothetici (ONT), 27 March, 10 April and 9 October. Laine, M.L. (2015, February 06). Wat vertelt je ademgeur? Amsterdam, the Netherlands, ANT congress. Nicu, E.A. (2015, November 19). Host-pathogens interactions: the role of polymorphonuclear neutrophilic granulocytes in the oral cavity. Utrecht, the Netherlands, Symposium: Dental Pharmacy organized by the Honours Programme of the Faculty of Pharmacology, UMC. Bloemena E. (2015, March 19). Speekselkliertumoren: pathologie diagnostiek. NH Hotel Sparrenbos, Nunspeet, the Netherlands, VAP congres Bloemena E. (2015, April 24). Speekselkliertumoren: inzichten in de moleculaire pathologie. FIGI, Zeist, the Netherlands, Pathologendagen. De Visscher, J.G.A.M. (2015, March 06). Aangezichtstrauma. Ede, the Netherlands, 29e LVO congres. De Visscher, J.G.A.M. (2015, November 18). Enkele aandoeningen van de speekselklieren. Sneek, the Netherlands, Huisartsen en specialisten Antonius ziekenhuis. De Visscher, J.G.A.M. (2015, May 29). Witte en rode veranderingen in het mondslijmvlies. Breukelen, the Netherlands, Voorjaarsvergadering NVMKA. Laheij, A.M.G.A. (2015, November 27). De nieuwe Richtlijn Infectiepreventie voor Mondzorgpraktijken, een update. Symposium voor tandartsassistenten. ACTA, Amsterdam. Meester, M. (2015, March 17). Mondzorg bij de oncologische patiënt. Amsterdam, the Netherlands, Klinische les afdeling VKNO VUmc. Rademacher, W.M.H. (2015, November 06). Digitale omsluiting van geneesmiddelenbijwerkingen, relevant voor het hoofd-halsgebied. De kwaliteit van een kwaliteitsmodule. Amersfoort, the Netherlands, NVMKA najaarsvergadering. Rosema, N.A.M. (2015, November 27). Mondhygiëne: een update. Amsterdam, the Netherlands, Assistenten symposium, ACTA. Rosema, N.A.M. (2015, October 15). Poetsen anno 2015. Amsterdam, the Netherlands, Verwijzersavond Parodontologie, ACTA. Rosema, N.A.M. (2015, November 27). Tandenpoetsen anno 2015. Ede, the Netherlands, NVvP-Congress Up to date, Cinemec. Rozema, F.R. (2015, November 20). 9d. Gezondheid door de mond gezien. Apeldoorn, the Netherlands, Nascholing symposium. Rozema, F.R. (2015, March 27). 9d. Ongezond, wat zien we in de mond? Soest, the Netherlands, Nederlandse Vereniging voor Orthodontie. Rozema, F.R. (2015, December 18). 9d. Richtlijnen antibiotica profylaxis. Amsterdam, the Netherlands, Rondetafelbijeenkomst. Slot, D.E. (2015, April 17). Het preventie ABC. Amersfoort, the Netherlands, Preventie Academie Ivoren Kruis. Slot, D.E. (2015, June 16). Listerine, wat is het wetenschappelijk bewijs? Amstelveen, the Netherlands, Porter Novelli. Smeele, L.E. (2015, June 22). Current treatment strategies for advanced cancer of the head and neck. Amsterdam, the Netherlands, Symposium Mondproblemen bij de oncologische patiënt, AVL/NKI.

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Teeuw, W.J. (2015, November 18). Diabetes en mondgezondheid. Hilversum, the Netherlands, Webinar KNMT. Van der Waal, I. (2015, January 09). De mondziekten als spiegel van de gezondheid. Leiden, the Netherlands, Afscheidssymposium prof.dr. C.M. ten Bruggenkate. Van der Waal, I. (2015, March 25). Mondziekten; een update. the Netherlands, Leiderdorp. Van der Weijden, G.A. (2015, March 06). De kracht en zwakte van het parodontium. Amsterdam, the Netherlands, Paro 2015, RAI. Van der Weijden, G.A. (2015, June 22). Esthetic risk profile & air polisher. Utrecht, the Netherlands, Paro Praktijk Utrecht, 22 June, 12 October, 12 and 18 November. Van der Weijden, G.A. (2015, March 24). Esthetic risk profile & air polisher. Groningen, the Netherlands, Paro Praktijk Groningen. Van der Weijden, G.A. (2015, October 15). Nazorg bij implantaten en air polisher. Utrecht, the Netherlands, Paro Praktijk Utrecht. Van der Weijden, G.A. (2015, December 18). Oral-systemic link, from science to daily practice part 2. Directe bacteriologische interactie. Amsterdam, the Netherlands, Philips Oral Healthcare - Round Table. Van der Weijden, G.A. (2015, November 16). The best evidence for dental hygiene. Utrecht, the Netherlands, Paro Praktijk Utrecht. Van der Weijden, G.A. (2015, January 21). Ultrasoon. Utrecht, the Netherlands, Workshop Paro Praktijk Utrecht. Van Diermen, D.E. (2015, May 13). Medisch Tandheelkundige Interactie. Rijksmuseum, Amsterdam, the Netherlands, Nederlandse Vereniging voor Parodontologen (NVvP). Van Diermen, D.E. (2015, November 13). Een doekje voor het bloeden of doen alsof je neus bloedt? Amsterdam, the Netherlands, NVOI Najaarscongres.

Professional functions in the Netherlands Bloemena, E.: Chair - Committee Bij- en Nascholing NVVP. Bloemena, E.: Member - Committee Kwaliteit en Beroepsuitoefening NVVP. Bloemena, E.: Member - Committee richtlijn Hoofd Hals Kanker. Bloemena, E.: Board member - NVVP. Bloemena, E.: Chair - Wetenschappelijke Raad PALGRA. Brand, H.S.: Member - Ondernemingsraad ACTA, start: 1 July. Danser, M.M.: Chair - Nederlandse Vereniging voor Parodontologie (NVvP), 2013-2015. De Soet, J.J.: Lid - KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken, KNMT Nieuwegein. Gorter, R.C.: Vervangend lid Algemene Interfacultaire Ethische Commissie - UvA. Laheij, A.M.G.A.: Lid - KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken, KNMT Nieuwegein. Laheij, A.M.G.A.: Lid KNMT Commissie OnderzoeksBegeleiding - KNMT Nieuwegein. Rosema, N.A.M.: Lid beoordelingscommissie KRM - Kwaliteitsregister Mondhygiënisten, Nieuwegein, the Netherlands. Rozema, F.R.: Member - Ad Hoc Committee, Toewijzingopleidingscapaciteit MKA, NVMKA. Rozema, F.R.: Chair - Consilium Chirurgicum Oris. Van Bruchem-Laheij, A.M.G.A.: Member - Commissie onderzoeksbegeleiding KNMT. Van Bruchem-Laheij, A.M.G.A.: Member - Commissie Richtlijn Infectiepreventie voor Mondzorgpraktijken KNMT. Van der Heijden, G.J.M.G.: Visiting Fellowship - NYU. Van der Weijden, G.A. & Slot, D.E.: Redactie - Folder mondspoelmiddelen NVvP. Volgenant, C.M.C.: Lid - KNMT commissie Richtlijn infectiepreventie voor mondzorgpraktijken, KNMT Nieuwegein.

II. Societal relevance for the dental professional internationally

Professional functions internationally Brand, H.S.: Co-opted member - Association of Basic Science Teachers in Dentistry.

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Brand, H.S.: President-Elect - Salivary Research Group, International Association of Dental Research (IADR). Danser, M.M.: Member committee - EuroPerio9, November 2015 - June 2018. Elkerbout, T.A.: Member - Dental project in orphanages, Jinotepe, Nicaragua, 16-20 November. Loos, B.G.: Member committee - EuroPerio9, November 2015 - June 2018. Raber-Durlacher, J.E.: Active member - EORTC Quality of Life Group. Raber-Durlacher, J.E.: Leadership - Mucositis Study Group MASSC/ISOO. Rozema, F.R.: Chair - IT advisory committee IAOMS. Van der Heijden, G.J.M.G.: Visiting fellowship NYU.

Organization of international congresses and symposia for (health care) professional Slot, D.E. (2015). Organizing committee. IADR congress: Effect of aging on gingival tissue and periodontal disease: Boston, USA (2015, March 13). Teeuw, W.J. (2015). Organizing committee. Course Non-surgical therapy, Surinaamse Tandheelkundige Vereniging: Paramaribo, Surinam (2015, October 23 - 2015, October 26).

Invited speakers at international professional congresses or symposia De Jongh, A. (2015, August 25). 1. Treatment of fears and other anxiety-related conditions with EMDR. 2. Advancing EMDR through research for EMDR therapists. Philadelphia, USA, EMDR International Association Conference, 25 August - 1 September 2015. De Jongh, A. (2015, November 05). Does 'Complex PTSD' need a phase-based treatment approach or not? New Orleans, USA, ISTSS Conference, 5-7 November 2015. Duijster, D. (2015, November 21). Family Matters: De rol van het gezin in cariëspreventie bij kinderen uit sociaaleconomische en etnische risicogroepen. Amersfoort, the Netherlands, Het Ivoren Kruis congres: Succesvolle communicatie met uw patiënt. Slot, D.E. (2015, October 24). Dental implant hygiene; what do we need to do and what can patients do? Lisbon, Portugal, Caramês Advanced Education Center (CAEC). Slot, D.E. (2015, November 07). Dental implants; how should they be cleaned by the DCP and their owner? Sydney, Australia, DHAA. Slot, D.E. (2015, October 23). Dentine hypersensitivity the options. Lisbon, Portugal, Caramês Advanced Education Center (CAEC). Slot, D.E. (2015, May 09). Dentine hypersensitivity what can we do? Rome, Italy, AIDI. Slot, D.E. (2015, March 14). Interdental cleaning. Boston, USA, Lunch and learn, IADR. Slot, D.E. (2015, June 12). Interproximal cleaning and periodontal diseases -evidence today-. Malmo, Sweden, Tepe 50 years. Slot, D.E. (2015, November 06). Lasers for non-surgical periodontal therapy? Sydney, Australia, DHAA. Slot, D.E. (2015, September 11). Let’s take care for the elderly. Rome, Italy, Most asked Dental Hygiene Questions, a Quiz. Slot, D.E. (2015, November 05). Making evidence based practice work for you: strategies for keeping up with your research and The envolving role of the hygienist in the future. Sydney, Australia, DHAA Workshop. Slot, D.E. (2015, December 07). Research methodology and systematic reviews. Kiel, Germany, Workshop 7-9 December. Slot, D.E. (2015, November 04). Should we rinse then? Sydney, Australia, Sydney University. Slot, D.E. (2015, October 15). The dental hygienist in the Netherlands. Munich/Seefelt, Germany, 3M European dental hygienists. Teeuw, W.J. (2015, October 28). Parodontitis en algemene gezondheid. Paramaribo, Surinam, Surinaamse Tandheelkundige Vereniging. Teeuw, W.J. (2015, April 17). De interactie. Parodontitis en welvaartsziekten? Henri Schein, Almere, the Netherlands, 17 & 18 April, Colgate Oral health network. Teeuw, W.J. (2015, October 28). Parodontitis en algemene gezondheid. Paramaribo, Surinam, Surinaamse Tandheelkundige Vereniging. Van der Weijden, G.A. (2015, April 17). Bone management. Dusseldorf, Germany, Workshop, Meisinger.

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Van der Weijden, G.A. (2015, May 29). Esthetic risk profile & safety and efficacy of powered toothbrushes. Belgium, Gent. Van der Weijden, G.A. (2015, July 14). Safety and efficacy of powered toothbrushes. Germany, Kronberg.

III. Contacts with the general public

Interactions with the press and the general public Bizzarro, S. (2015). Antibiotica werkt niet altijd bij ernstige tandvleesontsteking. Interview Nederlands Tijdschrift voor Tandheelkunde (online December, 4). www.ntvt.nl/nieuws/promotie-s-bizzarro (in print NTVT January 2016, 123: 9). Bruers, J.J.M. (2015). Tandartsen moeten laten zien hoe goed ze zijn. Interview Nederlands Tandartsenblad 2: 11-13. De Jongh, A. (2015). Een gaatje in je kies? Even de gebruiksaanwijzing lezen en smeer hem zelf dicht. Interview Algemeen Dagblad. De Jongh, A. (2015). Overigens. Beslissingen over euthanasie kun je beter aan de eigen arts overlaten. Die kent de situatie van de patiënt het beste. Interview Folia Magazine 18. Jaargang 4, pagina 38. De Jongh, A. (2015). Overigens. De beste docenten verdienen het om hoogleraar te worden. Interview Folia Magazine 27. Jaargang 4, pagina 47. De Jongh, A. (2015). Mondzorg bij ouderen. Meldpunt, Omroep MAX TV uitzending (vanaf 31:59) http://www.omroepmax.nl/meldpunt/uitzending/tv/tijd-voor-meldpunt-hallo-nederland-vrijdag-3-april- 2015/. Duijster, D. (2015). Gezinssituatie cruciaal voor mondgezondheid kinderen. Interview Dentz, vakblad voor tandartsen, 7 (1), 14-17. Een goed gezin is het halve werk door Liza Leijenhorst; illustraties Denise Duijster. Duijster, D. (2015). Gezondheid kindergebit hangt ook af van ouders. Interview Parool en New Scientist door Sarah Prins. Eijkman, M.A.J. (2015). Andere tijden; drinkwaterfluoridering (bron: proefschrift dr. H.A. Edeler). Bijdrage VPRO/NPO-2 uitzending (May,12). Elkerbout, T.A. (2015). Mondhygiënist van het jaar 2015. Interview Nederlands Tijdschrift voor Mondhygiëne 7: 33. 14th VPM-congress, Vereniging ter Promotie van Mondhygiëne (VPM): Ede, the Netherlands (September, 18). Krom, B.P. (2015). Zitten tandenborstels echt vol poepresten? Interview Volkskrant. Loos, B.G. (2015). Hoe meer we weten, hoe ingewikkelder het wordt. Interview Nederlands Tijdschrift voor Mondhygiëne, no. 1 January: 14-16. Loos, B.G. (2015). Niet de tanden trekken. Interview c2W Life Sciences, no. 4: 21 (March, 13). Rosema, N.A.M. (2015). BNR. Interview (December, 30). Rosema, N.A.M. (2015). Tandpasta maakt tandenborstel niet effectiever tegen plaque. Marieke Epping, Dental Tribune. Interview (June). Rosema, N.A.M. (2015). Editie NL. Interview (October, 19). Rosema, N.A.M. (2015). Wat je misschien verkeerd doet als je je tanden poetst. Francisca ten Brinke, Gezond.NU. Interview (December). Rosema, N.A.M. (2015). KASSA. Interview (September, 26). Rosema, N.A.M. (2015). Life is Beautiful. Interview (February, 22). Rosema, N.A.M. (2015). NOS op 3. Interview (April, 21). Rosema, N.A.M. (2015). Tijd is niet het juiste criterium. Sacha Eikenboom, NVvP Fundamenteel. Interview (October, 1). Rosema, N.A.M. (2015). Radio 1 België. Interview (April, 22). Rosema, N.A.M. (2015). Radio 1 NL. Interview (April, 30). Rosema, N.A.M. (2015). Radio 538, 10, BNR, 1 & 2. Interviews (April, 16). Rosema, N.A.M. (2015). RTV NH. Interview (May, 21). Rosema, N.A.M. (2015). The battle of the brushes. Renske Thomas, Tandartspraktijk nr. 5 Interview (May, 1). Rosema, N.A.M. (2015). Kieskeurig met tandenborstel. Thijs Rosken, Telegraaf. Interview (April, 16). Rosema, N.A.M. (2015). Parodontax of huismerk: merk tandpasta maakt niets uit. Margreet Vermeulen, Volkskrant. Interview (April, 18). Slot, D.E. (2015). Duur is niet altijd beter. Interview Tandartspraktijk, 36 (6), 42-43. Promotie van mevrouw D.E. Slot.

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Slot, D.E. (2015). Klinisch epidemioloog en mondhygiënist Dagmar Else Slot over haar promotie: Wetenschappelijk bewijs voor nut chloorhexidine gels en laser ontbreekt. Interview Fundamenteel 88, 10- 11. Promotie van mevrouw D.E. Slot. Van der Veen, M.H. (2015). Tandplak in een ander licht. Eureka festival. Amsterdam, (2015, November 29). Van der Veen, M.H. (2015). Poetslessen Hou je mond gezond i.s.m. het ivoren kruis op 20 basisscholen. Van Diermen, D.E. (2015). Spreken over kleine ongemakken. Interview Quality Practice Mondhygiëne 7 (4), 4- 6: (2015, June 01). Van Wijk, A.J. (2015). Bijdrage als pijnspecialist aan programma De Buitendienst, School TV NTR (March, 6) http://www.schooltv.nl/video/de-buitendienst-pijn/#q=pijn. Zaura, E. (2015). Procedures infectiepreventie zijn meer dan een tijdrovende verplichting. Interview Quality Practice Mondhygiëne 7 (3), 4-6: (2015, May 01).

Inaugural lectures professorship Forouzanfar, T. (2015). Kaakchirurgie naar een nieuwe dimensie. Benoeming hoogleraar Mondziekten, Kaak- en Aangezichtschirurgie (2015, February 05). Auditorium, Amsterdam, the Netherlands: Vrije Universiteit Amsterdam. Keijser, B.J.F. (2015, November 20). De mond vol (van) bacteriën. Universiteit van Amsterdam, the Netherlands, Benoeming bijzonder hoogleraar Oral Systems Biology.

Impact of the research on the general public or professionals Brand, H.S. Workshop Speeksel: een ingewikkelde vloeistof. Landelijke Contactdag Nederlandse Vereniging van Sjögren Patiënten. Ede. 3 October 2015. Oral and Maxillofacial Surgery AMC. Three standards have been drawn up for the Dutch association for Oral and Maxillofacial Surgery (Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie, NVMKA). Oral and Maxillofacial Surgery VUmc. The guidelines for diagnosis and treatment of patients have been adopted by the Dutch association for Oral and Maxillofacial Surgery (Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie, NVMKA). Preventive Dentistry. Patients referred to the cariology clinic by their dentist are seen and advised.

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Oral Regenerative Medicine

Program Leaders

Prof.dr. D. Wismeijer Department of Oral Implantology and Prosthodontics ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980297 E mail: [email protected]

Dr. C.J. Kleverlaan Department of Dental Materials Sciences ACTA Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980882 E mail: [email protected]

Full professors

A.G. Becking C.M. ten Bruggenkate V. Everts A.J. Feilzer T. Forouzanfar

S. Gibbs J. Klein-Nulend J. de Lange F. Lobbezoo F.J.M. Roeters

E.A.J.M. Schulten P.F. van der Stelt D.B. Tuinzing

Introduction The human masticatory system has several important functions that determine an individual’s general health and well-being, like biting, chewing, swallowing, talking, laughing, and yawning. Sometimes, patients are confronted with problems in performing these functions. This may have various causes. On the one hand, chemical and bacteriological factors may hamper a healthy functioning of the masticatory system by causing infection and inflammation. On the other hand, mechanical overloading as well as underloading or disuse of

59 Annual Research Report 2015 the constituent structures of the masticatory system (viz., teeth, bone, cartilage, muscles, and joints) may yield functional oromandibular impairments. Importantly, trauma or disease may result in damaged tissues which in turn result in functional oromandibular impairments. The research of ACTA’s research program “Oral Regenerative Medicine” (ORM) focuses on regenerating damaged oral tissue by means of stem cell therapy or tissue engineering techniques, taking into account the mechanical threats for the masticatory system and inflammatory reactions involved in tissue repair. Relevant clinical problems are used to guide the research aimed at developing novel solutions for these clinical problems. Groups that are involved in ORM-ACTA are Oral Kinesiology (OKI), Oral Implantology and Prosthodontics (IMP), Dental Materials Sciences (DMS), Oral Cell Biology and Functional Anatomy (OCB/FA), Oral Radiology (ORA), Orthodontics (ORT), and Oral and Maxillofacial Surgery (OMS), both of the Academic Medical Center (AMC) and of the VU University Medical Center (VUmc). The Interfaculty MOVE Research Institute Amsterdam has chosen “Regenerative Medicine” as one of its domains (i.e., a collaboration of researchers within the VU campus on a key topic). Likewise, ORM has been formulated as one of the two priority areas (“zwaartepunt”) of ACTA. As implied above, a healthy oral system is characterized not only by the absence of infection and/or inflammation of dental and periodontal tissues, but also by a healthy musculoskeletal system and oral mucosa. Musculoskeletal tissues (i.e., bone, cartilage, muscles, and joints) and mucosa (epithelium and underling connective tissue) can be damaged or even destroyed by, for example, mechanical overloading, disuse, disease or trauma. In case of tissue loss, the replacement or regeneration of degenerating/degenerated cells, tissues, or organs is needed to restore or establish normal function. ORM studies these processes both at a fundamental and translational level in multidisciplinary settings, in which dentistry/oral medicine closely collaborates with medical disciplines like orthopaedics, neurology and dermatology/ plastic surgery, both within and outside The Netherlands. The main objectives of ORM-related research are the degenerating/degenerated oral tissues and an improved ability to replace or regenerate these tissues, thereby restoring oral function and thus oral health-related quality of life. The ultimate goal of oral regenerative medicine is to regenerate parts of the masticatory system, e.g. teeth, jaw bone and/or mucosa. Since this dot on the horizon is far away, we now concentrate on: A. Regeneration of jaw bone and oral mucosa. B. Local tissue and systemic (immune) response of the host to implant materials and restoratives. C. Implementing new technologies in the repair and restoration of oral and maxillofacial structures D. Gaining in-depth knowledge of non-infectious diseases of the masticatory system.

Research objectives

A. Regeneration of jaw bone and oral mucosa Stem cells and smart substrates Adipose tissue derived stem cells have been used to heal bone defects in human jaws. The application of these cells proved to result in an improved healing of the bone defects. In the coming period this will be further explored making use of different types of biological and non-biological substrates (see B ). After we successfully determined the safety and efficacy of adipose stem cells together with a bone substitute material for bone regeneration in a clinical phase 1 study, we will continue to use maxillary sinus floor elevation as a valid model to test bone tissue engineering approaches.

3D printing and biomimetic coating - CAD/CAM By making use of 3D bioprinters and the biomimetic coating developed in this research program, scaffolds containing (stem) cells and proteins will be constructed that can be implanted. The biomimetic coating involves the use of different growth factors that modulate cell behaviour and activity. By combining these different modalities it will be possible to finely tune tissue formation at sites wished for. Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) of tooth replacement, crown and bridgework and guided implant placement devices used to insert both tooth root implants as well as implants used to substitute bone loss based on CBCT scans combined with planning and designing software also being developed in this research program. In a joint project with industry the technology used to 3D print composite, PMMA and ceramics in crown and bridgework is being refined.

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A project focussed on the milling / printing of full tooth implants has shown that we can print teeth in titanium and zirconium within the same dimensions as the tooth scanned with CBCT. This technology makes it possible to design and fabricate one off implants for the specific bone volume in the individual patient.

B. Tissue response of the host to implant materials and restoratives Tissue response of the host Tissue lost after trauma or surgical intervention should be replaced or, most preferably, regenerate. In this part of the programme regeneration is induced by making use of a wide variety of scaffold materials, different cell types (e.g. stem cells) and a variety of growth factors and cytokines. The collaboration between clinical and non-clinical scientists from different departments and backgrounds (dental material sciences, implantology, oral cell biology) ensures a multi-disciplinary approach. It becomes more and more clear that implant materials long thought being harmless are now found to evoke an immunological response. Since the use of implant material increases tremendously knowledge about the response of these materials is of crucial importance. Whereas in the majority of cases, implants remain inert in the host, in some cases adverse events are observed e.g. host responses can include bioreabsorption (breakdown) of the implant material resulting in leachables, entering the surrounding tissue and systemic circulation. The local tissue effects include an inflammatory response leading to adjacent mucosa and bone degradation, irritation to the surrounding tissues and sensitization of the host. Systemic effects are largely not yet investigated but do include allergic skin rash. It is of utmost importance to develop safe biomaterials and implants for oral regenerative medicine. For this topic scientists with different background join forces in order to tackle these issues. Two approaches to this research line are investigated: 1) Safety assessment of dental implants. For this the Adverse Outcome Pathway (AOP) approach is used to investigate potential inflammatory responses in full compliance with the 3Rs.. Toxicity, irritation and sensitization are the focus. Both organotypic in vitro tissue engineered oral mucosa and bone constructs are used as healthy and disease models with integrated immune cells (eg Langerhans Cells) as well as traditional cell cultures. 2) Improved diagnostic testing of questionable adverse events to dental materials. Currently the skin patch is used to identify an allergic response of the individual to a dental implant. Due to differences in skin and oral immunity as well as cutaneous penetration, often false negatives are diagnosed. Improved patch testing methods, (eg use of microneedles and different salts) as well as in vitro lymphocyte proliferation and cytokine tests are being investigated a alternatives.

Biological response to loading The maintenance and survival of tissues like bone and cartilage largely depend on mechanical loading exerted upon these tissues. The different cell types that harbour these tissues are mechanosensitive and respond to mechanical loading. Also the stiffness of the substrate the cells live on, has profound effects on their metabolic activities. A combination of substrate stiffness and mechanical loading will make it possible to direct the cells in such a way that they generate tissues wished for, such as bone and cartilage. Insight in the interaction between implanted material either being of biological non-biological origin and the surrounding tissues is of crucial importance for the understanding how the host respond to the implanted material. Special attention is paid to the response of the tissue under conditions of mechanical loading or unloading.

Response of oral mucosa to injury Oral mucosa in contrast to skin heals rapidly and with almost scar free healing. With the aid of physiologically relevant tissue engineered oral mucosa and skin constructs, mechanisms of healing are compared in vitro. In particular, differences in proliferation, migration and differentiation of the epithelium and the deposition of extracellular matrix by (myo-)fibroblasts is investigated. Trafficking of immune cells involved in determining the quality of scar formation is the focus as well as the impact of the environment e.g. air versus saliva. In addition to saliva, the role of the oral microbiome (oral healthy and pathogenic biofilm) is investigated with regards to oral mucosa homeostasis and wound healing. Once normal healing mechanisms are established, the models can be used to investigate the mode of action of novel therapeutic compounds in vitro.

C. Gaining in depth knowledge of non-infectious diseases of the masticatory system. Pain, trauma and dysfunction Overloading of the constituent tissues of the masticatory system, notably cartilage, bone, muscle tissue, periodontal tissues, and hard dental tissues due to bruxism (i.e., tooth grinding and clenching) and adverse

61 Annual Research Report 2015 oral habits (e.g., nail biting and excessive gum chewing) may lead to pain and dysfunction of the chewing apparatus. In turn, such conditions may yield risks for the individual’s general health and cognitive abilities. A threat to the success of dental implants is peri-implant disease which is characterized by bone loss around the individual implants. The secondary cause of this bone loss is infection. The primary cause of peri-implant bone loss can be overloading, immunological response to the implant material. Within the framework of ORM, the causes, consequences, and management of pain, trauma and dysfunction of the masticatory system are studied in multiple international and multidisciplinary settings. The following items are studied: - diagnosis, epidemiology, pathophysiology, and management of bruxism, obstructive sleep apnea and orofacial pain. - relationship between mastication and cognition in elderly institutionalized persons with different types of dementia - surgical treatment strategies for orthognatic defects - incidence and treatment of maxillofacial trauma - peri-implantitis

Results obtained A. Regeneration of jaw bone and oral mucosa Stem cells and smart substrates  Biomimetic calcium phosphate coating can be a carrier for bone morphogenetic protein (BMP). Six studies were published in which the release was investigated of bone morphogenetic protein (BMP) incorporated into Calcium Phosphate as a carrier. This technology known as biomimetic coating has been the basis for research at ACTA during the last 8 years. It has been shown to be an effective bone substitute in critical size defects promoting osteogenesis and enhancing bone growth.  Additive manufacturing is the process of joining materials to create objects from digital 3-dimensional (3D) model data, which is a promising technology in oral and maxillofacial surgery. We reviewed two of the current and emerging modalities for reconstruction of oral and maxillofacial bone defects, namely human maxillary sinus floor elevation as a valid model to test bone tissue engineering approaches enabling the application of 1-step surgical procedures and seeding of Good Manufacturing Practice-level adipose stem cells on computer-aided manufactured scaffolds to reconstruct large bone defects in a 2-step surgical procedure, in which cells are expanded ex vivo and seeded on resorbable scaffolds before implantation. The potential of tissue engineered constructs designed for the repair of large oral and maxillofacial bone defects in load-bearing situations in a 1-step surgical procedure combining these 2 innovative approaches is particularly emphasized.  Polypyrrole (PPy) is a conducting polymer that enables controlled drug release upon electrical stimulation. We characterized the biocompatibility of PPy with human primary osteoblasts, and the effect of dopants. conducting polymers doped with dodecylbenzenesulfonate are well tolerated by osteoblasts. Our results could provide a basis for the development of novel orthopaedic or dental implants with controlled release of antibiotics and pharmaceuticals that fight infections or focally enhance bone formation in a tightly controlled manner.  Biomimetic coatings to increase endothelialisation of blood-contacting materials in biomedical devices are promising to improve the biocompatibility of these devices. Although a stable extracellular matrix protein coating on a biomaterial’s surface is a prerequisite for endothelial cell attachment, it also stimulates platelet adhesion. Therefore antithrombotic additives, such a nitric oxide donors, to a stable protein coating might lead to successful endothelialisation of a material’s surface. We showed that sodium nitrite- collagen conjugate coating with 25-50 M sodium nitrite on silicone tubes increases the number of endothelial cells attached and inhibits platelet adhesion suggesting that this coating is highly promising for use in blood-contacting parts of biomedical devices.  Surface modification by functional groups promotes endothelialisation in biohybrid artificial lungs, but whether it affects endothelial cell stability under fluid shear stress, and the release of anti-thrombotic factors, e.g. nitric oxide (NO), is unknown. We found that silicone-surface modification of blood-contacting parts of artificial lungs with carboxyl and amine, but not peroxide-groups followed by collagen immobilization allows the formation of a stable functional endothelial cell layer. Amine-group-modification seems undesirable since it affected silicone’s physical properties.

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 Two of the current and emerging modalities for reconstruction of oral and maxillofacial bone defects were investigated, namely human maxillary sinus floor elevation as a valid model to test bone tissue- engineering approaches enabling the application of 1-step surgical procedures and seeding of Good Manufacturing Practice-level adipose stem cells on computer-aided manufactured scaffolds to reconstruct large bone defects in a 2-step surgical procedure, in which cells are expanded ex vivo and seeded on resorbable scaffolds before implantation. Furthermore, imaging-guided tissue-engineering technologies to predetermine the surgical location and to facilitate the manufacturing of custom-made implants that meet the specific patient's demands were discussed. The potential of tissue-engineered constructs designed for the repair of large oral and maxillofacial bone defects in load-bearing situations in a 1-step surgical procedure combining these 2 innovative approaches was particularly emphasized.  The indications, results and complications of patients with cranio and maxillofacial defects treated with porous polyethylene (Medpor®) implants were investigated. The main reason for implant surgery was post-traumatic functional impairment. Most implants were placed at the mandibular angle and the orbital floor. Unsatisfactory appearance scored the highest in postoperative complications (10.1%) followed by infection rate (7.2%).  In a multi-disciplinary team a customizable ear model was developed for 3D printing of ear implants. The results demonstrated that the parametric standard model could be used as a feasible method to generate custom implants based on existing ear images.

3D printing and biomimetic coating - CAD/CAM  A study on the precision of intraoral scanners using different software packages and different clinical parameters used in operative dentistry showed that the are several clinical circumstances that influence the clinical outcome.  Two studies on the adoption of digital technologies by dental practitioners in the Netherlands showed that there are many barriers to overcome before digital technologies will be accepted for use in the general dental practice. These factors are based on the individual dentists interest, trust in digital systems, behaviour of colleagues and friends, as well as economic factors.  A series of CAD/CAM materials were investigated with the focus on the influence of restoration thickness, strength of the total restoration.

B. Tissue response of the host to implant materials and restoratives Tissue response of the host  Experimental studies on the release of nickel and palladium from dental appliances and clinical studies on potential side effects of this type of appliances.  A study on the use of CBCT scanners for the transfer accuracy of guided surgery systems in dental implant surgery showed that different systems have different levels of accuracy and that when trusting on surgical guides when following an non-invasive flapless protocol one has to be aware of these limitations. We are now focussing our attention to various possible calibration approaches.  A novel immune competent gingiva equivalent model (reconstructed gingiva epithelium with integrated Langerhans Cells on a fibroblast populated lamina propria) has been developed to investigate inflammatory responses caused by contact sensitizers and irritants including medical device metals in vitro. It was found that initial innate tissue and dendritic cells responses to chemicals are clearly very different to those occurring in skin.  Our epidermal equivalent assay for identifying and labelling sensitizers is undergoing world-wide validation in an international multi-centre study.  A number of in vitro assays developed to identify sensitizers from non-sensitizers have been used to investigate potential adverse effects of metals and leachables released from dental implants.

Biological response to loading  Research on the use of 4 reduced diameter implants (1.8-2.4 mm) supporting an over denture in the lower jaw showed encouraging results when evaluating patients quality of life. The results are comparable to more invasive approaches with normal diameter implants leading to more predictable treatment options for patients with limited bone volume.  Aging reduces bone mass as well as the anabolic response of bone to mechanical stimuli, resulting in osteopenia. Endoplasmic reticulum (ER) stress impairs the response of myogenic cells to anabolic stimuli, and is involved in sarcopenia, but whether ER stress also contributes to osteopenia is unknown. We found

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that the expression of several ER stress markers was higher in osteocytes from bones of old compared to adult mice. Since ER stress altered the response of osteocytes to mechanical loading, it could be a novel factor contributing to osteopenia. Anabolic resistance reflects the inability of skeletal muscle to maintain protein mass by appropriate stimulation of protein synthesis. We hypothesized that ER stress contributes to anabolic resistance in skeletal muscle with aging, but we found that ER stress is probably not involved in anabolic resistance in skeletal muscle with aging.  Insulin-like growth factor 1 (IGF-1) and interleukin 6 (IL-6) play an important role in the adaptation of both muscle and bone to mechanical stimuli. We have provided an overview of the functions of IL-6 and IGF-1 in bone and muscle metabolism, and the intracellular pathways that are well known to mediate these functions.  Generalized osteoporosis is common in patients with inflammatory diseases, possibly because of circulating inflammatory factors that affect osteoblast and osteoclast formation and activity. We found that CXCL8 and CCL20 did not decrease osteoblast proliferation or gene expression of matrix proteins. CXCL8 and CCL20 did not directly affect osteoclastogenesis. However, CXCL8 and CCL20 enhanced osteoblast-mediated osteoclastogenesis, partly via IL-6 production, suggesting that CXCL8 and CCL20 may contribute to osteoporosis in rheumatoid arthritis by affecting bone cell communication.  Multiple factors contribute to bone loss in inflammatory diseases such as rheumatoid arthritis (RA), but circulating factors and immobilization play a crucial role. Mechanical loading prevents bone loss in the general population, but the effects of mechanical loading in patients with RA are less clear. We found that RA serum containing inflammatory factors, did not alter the intrinsic capacity of osteocytes to sense mechanical stimuli, but upregulated osteocyte-to-osteoclast communication. Mechanical loading nullified this upregulation, suggesting that mechanical stimuli could contribute to the prevention of osteoporosis in inflammatory disease.  There is considerable variation in the shape of osteocyte lacunae, which is likely to influence the function of osteocytes as the professional mechanosensors of bone. We have discussed how mechanical loading could affect the shape of osteocyte lacunae, and how the shape of osteocytes could influence their mechanosensation. Altered lacunar morphology has been associated with bone pathology. It is important to know whether osteocyte shape is part of the etiology.  Adaptation of bone to mechanical stresses normally produces a bone architecture that combines a proper resistance against failure with a minimal use of material. This adaptive response is governed by mechanosensitive osteocytes. We have discussed current insights on how osteocytes perceive mechanical stimuli placed on whole bones. Particular emphasis is placed on the role of estrogen in signaling pathway activation by mechanical stimuli, and on computer simulation with cell biology to unravel biological processes contributing to bone strength.

Response of oral mucosa to injury  Tissue engineered skin and mucosa equivalents have been established from TERT immortalized cell lines and validated against the primary cell counterparts. The models consist of reconstructed epithelium on a fibroblast populated dermis or lamina propria. Inflammatory responses during wound healing and scar formation were investigated. Preliminary experiments have been performed to introduce oral healthy and pathogenic biofilm onto these organotypic mucosa equivalents.

Gaining in depth knowledge of non-infectious diseases of the masticatory system Pain, trauma and dysfunction  The long-term research line on the management of orofacial pain and temporomandibular disorders results in a continuous number of scientific papers on this topic. Among these studies, a large-scale epidemiological study was published with prevalence data of temporomandibular pain in the Dutch population. Research of the heritability of temporomandibular disorders showed that genetic factors are partly responsible for the development of temporomandibular pain.  Studies on the recognition of pain in persons with impaired cognition (like people with dementia or Down syndrome) are ongoing. For example, an international roadmap was published sketching the development of a multidisciplinary pain observation tool.  In a series of experimental and clinical studies, a positive association between mastication and cognition was found. These results may have important consequences for daily care of elderly persons.  Several studies on bruxism have contributed to an improved insight into the pathophysiology, diagnosis, consequences, and management of sleep bruxism.

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 A series of articles describes the outcomes of studies on various aspects of tooth wear. For example, a longitudinal study showed that a recently developed tooth wear grading scale is sensitive enough to monitor the progress of tooth wear over time.  Ongoing studies on the different types of cartilage in the temporomandibular joint aim to explain the clinical observation that condylar cartilage is more vulnerable for remodelling than the cartilage of the disc and fossa. The role of mechanical loading in this process is being studied as well.  A review of published studies of the last 30 years on traumatology showed that in American, African and Asian studies road traffic crashes were the predominant cause. In European studies the aetiology varied, with assaults and road traffic crashes being the most important factors. In Oceania assaults were the most important.  We found that measurements of the height of the ramus on orthopantomographic (OPT) images cannot be relied on as an absolute indication for surgical intervention in patients with mandibular condyle fracture.

Academic personnel in 2015 and 2016 Research staff ACTA – ORM Oral Regenerative Medicine (in full time equivalents) position Name fte 2015 plan 2016 funding Becking, prof.dr. A.G. 0,10 0,10 1 Bruggenkate, prof.dr. C.M. ten pm pm 1 Everts, prof.dr. V. 0,10 0,10 3 Feilzer, prof.dr. A.J. 0,05 0,05 1 Forouzanfar, prof.dr. T. 0,20 0,20 1 Gibbs, prof.dr. S. 0,45 0,45 1 Klein Nulend, prof.dr. J. 0,70 0,70 1 Lange, prof.dr. J. de 0,10 0,10 1 Lobbezoo, prof.dr. F. 0,15 0,10 1 Lobbezoo, prof.dr. F. 0,05 0,05 3 Full professors Prahl-Andersen, prof.dr. B. pm pm guest Ravesloot, prof.dr. J.H. pm pm guest Roeters, prof.dr. F.J.M. pm pm guest Schulten, prof.dr. E.A.J.M. 0,10 0,10 1 Stelt, prof.dr. P.F. van der pm pm 1 Tuinzing, prof.dr. D.B. 0,10 0,10 1 Vries, prof.dr. N. de -- 0,20 3 Wismeijer, prof.dr. D. 0,15 0,15 1 Wismeijer, prof.dr. D. 0,05 0,10 2 Wismeijer, prof.dr. D. 0,10 0,10 3 Zentner, prof.dr. A. 0,10 0,20 1 Bakker, dr. A.D. 0,70 0,70 1 Bronckers, dr. A.L.J.J. 0,05 -- 1 Hoekema, dr. A. -- 0,25 3 Kleverlaan, dr. C.J. 0,50 0,50 1 Kleverlaan, dr. C.J. 0,05 0,05 3 Koolstra, dr.ir. J.H. 0,60 0,60 1 Senior lecturers Kuitert, dr. R.B. 0,20 0,20 1 Langenbach, dr. G.E.J. 0,30 0,30 1 Liu, dr. Y. 0,60 0,50 1 Liu, dr. Y. 0,20 0,30 2 Liu, dr. Y. 0,10 0,20 3 Sanderink, dr. G.C.H. 0,05 0,05 1 Tahmaseb, dr. A. 0,30 0,30 1

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Position Name fte 2015 plan 2016 funding Tahmaseb, dr. A. 0,05 0,05 3 Visscher, dr. C.M. 0,35 0,30 1 Visscher, dr. C.M. 0,05 0,05 3 Baart, drs. J.A. 0,10 0,05 1 Berkhout, dr. W.E.R. 0,40 0,40 1 Bos, dr. A. 0,40 0,40 1 Dubois, drs. L. 0,10 0,10 1 Geraets, dr. W.G.M. 0,40 0,40 1 Lecturers and other tenured Goené, drs. R.J. pm pm guest staff Hassan, dr. B.A. 0,40 0,40 3 Jongsma, dr. L.A. 0,15 0,15 1 Koutris, drs. M. 0,30 0,25 1 Prahl, dr. C. 0,05 0,05 1 Selms, dr. M.K.A. van 0,15 0,10 1 Verheij, dr. H.G.C. 0,30 0,30 1 Wu, dr. G. 0,60 0,40 1 Wu, dr. G. 0,30 0,50 2 Total tenured staff 10,45 10,65 Aarab, dr. G. 0,30 0,35 1 Apperloo, drs. R.C. 0,10 0,10 1 Ashton-James, dr. C.E. pm pm guest Baravordeh, F. pm pm guest Bollen, K. pm pm guest Bontkes, dr. H.J. -- 0,80 1 Bruggeman, dr. J. P. 1,00 0,20 2 Byraki, drs. A.A. pm pm guest Campos, dds. F. 0,30 -- 3 Chin Jem Sen, drs. J. pm pm guest Chen, dds. L. 0,80 0,80 3 Cioccari Oliveira, dds. S. 0,90 -- 3 Damaskos, dr. S. 0,50 0,05 3 Derksen, drs. W.D.C. 0,55 0,55 3 Disse, drs. M.A. 0,05 0,05 1 Elyassi, MSc. Y. 0,10 0,20 3 Non tenured staff Eekeren, drs. P.J.A. van pm pm guest Entezami Rad, drs. N. pm pm guest Farhanghi, R. pm pm guest Farré-Guasch, dr. E. 0,30 0,30 3 Fernands, drs. G. pm pm guest Flügge, dds. T.V. 0,15 0,35 3 Fraga, dds. S. 0,75 -- 3 Gimenez, dds. B. 0,20 0,40 1 Gimenez, dds. B. 0,60 -- 3 Hattem, A.B. pm pm guest Hermus, R.R. pm pm guest Hoogeveen, MSc. R.C. 0,20 0,10 1 Iskender, S.Y. pm pm guest Jager, dr.ir. N., de 0,05 0,05 3 Jager, dr. D.H.J. 0,20 0,20 1 Kapagiannidou, drs. D. pm pm guest Knibbe, drs. W. 0,05 -- 1

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Position Name fte 2015 plan 2016 funding Kok, drs. P. de pm pm guest Kramer, dr. G.J.C. 0,10 0,10 1 Lin, dds. X. 0,75 0,75 3 Liu, dds. Y. 0,20 0,55 3 Loon, dr. J.J.W.A. van 0,10 0,10 1 Loon, dr. J.J.W.A. van 0,10 -- 2 Loon, dr. J.J.W.A. van 0,70 0,80 3 Maarse, MSc. F. 0,25 0,25 3 Meijer, drs. B.A. 0,05 -- 1 Milbradt Dutra, dds. D.A. 0,70 -- 3 Nolte, F.M. pm pm guest Oosterhuis, M. pm pm guest Osman, dds. R.B. 0,35 -- 3 Non tenured staff Parvaneh, drs. H. pm pm guest Pereira, dds. G. 0,40 0,40 3 Reyes Sevilla, drs. M. pm pm guest Slot, dr. D.E. -- 0,05 1 Uijlenbroek, drs. H.J.J. pm pm guest Vahed, MSc. F. -- 0,75 3 Weijenberg, dr. R.A.F. 0,05 0,05 1 Wetselaar, drs. P. 0,10 0,20 1 Willems, dr. N.M.B.K. 0,05 -- 1 Wolff, dr. J.E.H. 0,10 0,10 1 Wolff, dr. J.E.H. 0,40 0,40 3 Zandieh Doulabi, dr.ing. B. 0,65 0,65 1 Zembic, dds. A. pm pm guest Zygogiannis, dds. K. 0,30 0,30 3 Abdel Aziz, dds. M.F.A. pm pm guest Alharbi, dds.N.M. 0,75 0,75 3 Anssari Moin, drs. D. pm pm guest Asikainen, drs. P.J. pm pm guest Baas, drs. E.M. pm pm guest Baggen, drs. J.H.M. pm pm guest Bastidas Coral, dds. A.P. 0,80 0,80 1 Beerens, drs. M.W. pm pm guest Bergh, drs. B. van den pm pm guest Betti, MSc. B.F. 0,40 0,80 1 Boffano, dds. P. pm pm guest Bouwman, drs. W.F. pm pm guest PhD students Buskermolen, MSc. J.K. 0,75 0,75 1 Cao, MSc. Y. 0,75 0,75 3 Chalil, dds. S. pm pm guest Chen, dds. H. 0,75 0,75 3 Daher, dds. R. pm pm guest Delwel, drs. S. 0,25 0,25 3 Eijnatten, MSc. M. van 0,15 0,15 1 Eijnatten, MSc. M. van 0,30 0,30 3 Esterik, MSc. F.A.S. van 0,75 0,75 1 Evans, dds. C. pm pm guest Fazaeli, MSc. S. 0,70 0,50 1 Gobel, drs. J. pm pm guest

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Position Name fte 2015 plan 2016 funding Graaf, MSc. N.P.J. de 0,75 0,75 2 Gregor, dds. L. pm pm guest Grootel, drs. R.J. van pm pm guest Harkel, MSc. B. ten 0,70 0,50 2 Heidsieck, drs. D.S.P. pm pm guest Hemmatian, dds. H. pm pm guest Houwing, drs. M. pm pm guest Jalali, dds. R. 0,25 0,50 1 Jansen, dr. D.C. pm pm guest Jong, MSc. T. de 0,75 0,75 1 Kaaij, drs. N.C.W. van der 0,10 0,10 1 Karssemakers, drs. L.H.E. pm pm guest Kommers, MSc. S.C. pm pm guest Kuik, drs. D. pm pm guest Lourenco, dds. A.L.R. 0,20 -- 1 Lourenco, dds. A.L.R. 0,20 0,20 3 Maningky, drs. M.S. pm pm guest Milheiro, dr. A. pm pm 1 Mirahmadi, MSc. F. 0,75 0,75 3 Mokhtari-Jafari, dds. F. pm pm guest Muris, dr. J. 0,30 0,20 1 Muzalev, drs. K.S. pm pm guest Nikolopoulou, drs. M. pm pm guest Nolte, drs. J.W. 0,20 0,20 1 Oomens, drs. M.A.E.M. pm pm guest PhD students Pathak, MSc. J.L. 0,30 -- 1 Renders, drs. G.A.P. pm pm 1 Restrepo Serna, drs. C.C. pm pm guest Ridwan, drs. A. 0,10 0,10 1 Rozeboom, drs. A.V.J. pm pm guest Ruiter, drs. M.H.T. de pm pm guest Ruiz Zapata, dds. A.M. 0,05 -- 1 Ruslin, dds. M. 0,20 0,20 3 Salentijn, drs. E. pm pm guest Scholtanus, drs. J.D. pm pm guest Shang, MSc. L. 0,10 0,35 3 Sprangers, MSC. S.L. 0,75 0,75 3 Sleen, drs. J.C. van der pm pm guest Tabeian, MSc. H. 0,75 0,15 1 Tastepe, dds. C.S. 0,60 0,40 1 Täubock, drs. T.T.K.J. pm pm guest Teng, dds. F. 0,20 0,75 3 Tuijt, drs. M. pm pm guest Tuk, drs. J.C. pm pm guest Thymi, drs. M. 0,30 0,30 3 Veldhuizen, MSc. R. 0,75 0,75 2 Velzen, drs. F.J.J. van pm pm guest Verlinden, drs. C.R.A. pm pm guest Vorselen, MSc. D. 0,40 -- 2 Vries, MSc. M.W. de 0,05 0,15 1 Wang, dds. D. 0,75 0,75 3

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Position Name fte 2015 plan 2016 funding Zhang, dds. X. pm pm guest PhD students Zamani, dds. Y. pm pm guest Zande, MSc. M.M. van der 0,30 0,30 1 Total non tenured staff 28,40 25,40 total 1st funding 18,60 18,65 1 total 2nd funding 4,25 2,60 2 total 3rd funding 16,00 14,80 3 Total research staff 38,85 36,05

Output Dissertations Baas, E.M. (2015, July 01). Bilateral sagittal split osteotomy versus distraction osteogenesis for mandibular advancements. Universiteit van Amsterdam (141 pag.). Prom./coprom.: prof.dr. J. de Lange, prof.dr. A.G. Becking & dr. D.M.J. Milstein. Jansen, I.D.C. (2015, March 09). Functional differences between site-specific osteoclasts. VU University Amsterdam (190 pag.). Prom./coprom.: prof.dr. V. Everts & dr.ir. T.J. de Vries. Muris, J. (2015, January 23). Palladium allergy in relation to dentistry. Universiteit van Amsterdam (238 pag.). Prom./coprom.: prof.dr. A.J. Feilzer, prof.dr. R.J. Scheper, dr. B.M.E. von Blomberg, dr. C.J. Kleverlaan & prof.dr. T. Rustemeyer. Overman, J.R. (2015, January 23). Adipose stem cells for bone tissue engineering in a human maxillary sinus floor elevation model: studies towards clinical applications. VU University Amsterdam (192 pag.). Prom./coprom.: prof.dr. J. Klein Nulend, prof.dr. E.A.J.M. Schulten, dr. M.N. Helder & prof.dr. C.M. ten Bruggenkate. Pathak, J.L. (2015, June 19). The etiology of generalized osteoporosis in rheumatoid arthritis. VU University Amsterdam and KU Leuven University (172 pag.). Prom./coprom.: prof.dr. J. Klein Nulend, prof.dr. F.P. Luyten, dr. N. Bravenboer, dr. A.D. Bakker & prof.dr. P. Verschueren. Salehi-Nik, N. (2015, December 14). Improved endothelialization by silicone surface modification and fluid hydrodynamics modulation: Implications for oxygenator biocompatibility. VU University Amsterdam (168 pag.). Prom./coprom.: prof.dr. J. Klein Nulend, prof.dr. G. Amoabediny, dr. B. Zandieh Doulabi & prof.dr. M.A. Shokrgozar. Ventura Da Cruz Rodrigues Milheiro, A.M. (2015, November 27). Exposure to nickel and palladium from dental appliances. Universiteit van Amsterdam (127 pag.). Prom./coprom.: prof.dr. A.J. Feilzer & dr. C.J. Kleverlaan.

Scientific publications (refereed) Aceto, J., Nourizadeh-Lillabadi, R., Marée, R., Dardenne, N., Jeanray, N., Wehenkel, L., Aleström, P., van Loon, J.J.W.A. & Muller, M. (2015). Zebrafish bone and general physiology are differently affected by hormones or changes in gravity. PLoS One, 10 (6), e0126928. doi: 10.1371/journal.pone.0126928 Asikainen, P., Sirviö, E., Mikkonen, J.J.W., Singh, S.P., Schulten, E.A.J.M., ten Bruggenkate, C.M., Koistinen, A.P. & Kullaa, A.M. (2015). Microplicae: specialized surface structure of epithelial cells of wet-surfaced oral mucosa. Ultrastructural Pathology, 39 (5), 299-305. doi: 10.3109/01913123.2015.1054015 Baas, E.M., Bierenbroodspot, F. & de Lange, J. (2015). Bilateral sagittal split osteotomy versus distraction osteogenesis of the mandible: a randomized clinical trial. International Journal of Oral and Maxillofacial Surgery, 44 (2), 180-188. doi: 10.1016/j.ijom.2014.10.010 Baas, E.M., Bierenbroodspot, F. & de Lange, J. (2015). Skeletal stability after bilateral sagittal split osteotomy or distraction osteogenesis of the mandible: a randomized clinical trial. International Journal of Oral and Maxillofacial Surgery, 44 (5), 615-620. doi: 10.1016/j.ijom.2014.12.011 Baas, E.M., van Gemert, B.P.H.M., Bierenbroodspot, F., Milstein, D.M.J. & de Lange, J. (2015). Patient discomfort and other side effects after bilateral sagittal split osteotomy or distraction osteogenesis of the mandible: a randomized clinical trial. International Journal of Oral and Maxillofacial Surgery, 44 (9), 1119- 1124. doi: 10.1016/j.ijom.2015.05.016

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Bakker, A.D. & Jaspers, R.T. (2015). IL-6 and IGF-1 signaling within and between muscle and bone: how important is the mTOR pathway for bone metabolism? Current Osteoporosis Report, 13 (3), 131-139. doi: 10.1007/s11914-015-0264-1 Beerens, M.W., Boekitwetan, F., van der Veen, M.H. & ten Cate, J.M. (2015). White spot lesions after orthodontic treatment assessed by clinical photographs and by quantitative light-induced fluorescence imaging; a retrospective study. Acta Odontologica Scandinavica, 73 (6), 441-446. doi: 10.3109/00016357.2014.980846 Berkhout, W.E.R., Suomalainen, A., Brüllmann, D., Jacobs, R., Horner, K. & Stamatakis, H.C. (2015). Justification and good practice in using handheld portable dental X-ray equipment: a position paper prepared by the European Academy of DentoMaxilloFacial Radiology (EADMFR). Dentomaxillofacial Radiology, 44 (6):20140343. doi: 10.1259/dmfr.20140343 Bins, A., Baart, J.A., Forouzanfar, T. & van Loon, J.J.W.A. (2015). A comparison of torque forces used to apply intermaxillary fixation screws. Journal of Oral and Maxillofacial Surgery, 73 (12), 2367-2374. doi: 10.1016/j.joms.2015.09.001 Bins, A., Oomens, M.A.E., Boffano, P. & Forouzanfar, T. (2015). Is there enough evidence to regularly apply bone screws for intermaxillary fixation in mandibular fractures? Journal of Oral and Maxillofacial Surgery, 73 (10), 1963-1969. doi: 10.1016/j.joms.2015.03.072 Bizzarri, M., Monici, M. & van Loon, J.J.W.A. (2015). How microgravity affects the biology of living systems. BioMed Research International, 2015:863075. doi: 10.1155/2015/863075 Boffano, P., Kommers, S.C., Karagozoglu, K.H., Gallesio, C. & Forouzanfar, T. (2015). Mandibular trauma: a two-centre study. International Journal of Oral and Maxillofacial Surgery, 44 (8), 998-1004. doi: 10.1016/j.ijom.2015.02.022 Boffano, P., Kommers, S.C., Roccia, F. & Forouzanfar, T. (2015). Mandibular trauma treatment: a comparison of two protocols. Medicina Oral Patologia Oral y Cirurgia Bucal, 20 (2), e218-e223. doi: 10.4317/medoral.20263 Boffano, P., Roccia, F., Zavattero, E., Dediol, E., Uglešić, V., Kovačič, Ž., Vesnaver, A., Konstantinović, V.S., Petrović, M., Stephens, J., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P.F., Bakardjiev, A.G., Malanchuk, V.A., Kopchak, A.V., Galteland, P., Mjøen, E., Skjelbred, P., Bertin, H., Marion, F., Guiol, J., Corre, P., Løes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, K.H., Kommers, S.C. & Forouzanfar, T. (2015). Assault-related maxillofacial injuries: the results from the European Maxillofacial Trauma (EURMAT) multicenter and prospective collaboration. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 119 (4), 385-391. doi: 10.1016/j.oooo.2014.12.012 Boffano, P., Roccia, F., Zavattero, E., Dediol, E., Uglešić, V., Kovačič, Ž., Vesnaver, A., Konstantinović, V.S., Petrović, M., Stephens, J., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P.F., Bakardjiev, A.G., Malanchuk, V.A., Kopchak, A.V., Galteland, P., Mjøen, E., Skjelbred, P., Grimaud, F., Fauvel, F., Longis, J., Corre, P., Løes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, K.H., Kommers, S.C., Meijer, B. & Forouzanfar, T. (2015). European Maxillofacial Trauma (EURMAT) in children: a multicenter and prospective study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 119 (5), 499-504. doi: 10.1016/j.oooo.2014.12.012 Boffano, P., Roccia, F., Zavattero, E., Dediol, E., Uglešić, V., Kovačič, Ž., Vesnaver, A., Konstantinović, V.S., Petrović, M., Stephens, M., Kanzaria, A., Bhatti, N., Holmes, S., Pechalova, P.F., Bakardjiev, A.G., Malanchuk, V.A., Kopchak, A.V., Galteland, P., Mjøen, E., Skjelbred, P., Koudougou, C., Mouallem, G., Corre, P., Løes, S., Lekven, N., Laverick, S., Gordon, P., Tamme, T., Akermann, S., Karagozoglu, K.H., Kommers, S.C. & Forouzanfar, T. (2015). European Maxillofacial Trauma (EURMAT) project: a multicentre and prospective study. Journal of Cranio-Maxillofacial Surgery, 43 (1), 62-70. doi: 10.1016/j.jcms.2014.10.011 Bos, E.J., Scholten, T., Song, Y., Verlinden, J.C., Wolff, J., Forouzanfar, T., Helder, M.N. & van Zuijlen, P. (2015). Developing a parametric ear model for auricular reconstruction: a new step towards patient-specific implants. Journal of Cranio-Maxillofacial Surgery, 43 (3), 390-395. doi: 10.1016/j.jcms.2014.12.016 Brand, H.S., van der Cammen, C.C.J., Roorda, S.M.E. & Baart, J.A. (2015). Tooth extraction education at dental schools across Europe. British Dental Journal, 1:15002. doi: 10.1038/bdjopen.2015.2 Bronckers, A.L.J.J., Lyaruu, D., Jalali, R., Medina, J.F., Zandieh-Doulabi, B. & DenBesten, P.K. (2015). Ameloblast modulation and transport of Cl-, Na+, and K+ during amelogenesis. Journal of Dental Research, 94 (12), 1740-1747. doi: 10.1177/0022034515606900 Bronckers, A.L.J.J., Lyaruu, D.M., Guo, J., Bijvelds, M.J.C., Bervoets, T.J.M., Zandieh-Doulabi, B., Medina, J.F., Li, Z., Zhang, Y. & DenBesten, P.K. (2015). Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice. European Journal of Oral Sciences, 123 (1), 9-16. doi: 10.1111/eos.12163

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Chalil, S., Jaspers, R.T., Manders, R.J., Klein-Nulend, J., Bakker, A.D. & Deldicque, L. (2015). Increased endoplasmic reticulum stress in mouse osteocytes with aging alters Cox-2 response to mechanical stimuli. Calcified Tissue International, 96 (2), 123-128. doi: 10.1007/s00223-014-9944-6 Chalil, S., Pierre, N., Bakker, A.D., Manders, R.J., Pletsers, A., Francaux, M., Klein-Nulend, J., Jaspers, R.T. & Deldique, L. (2015). Aging related ER stress is not responsible for anabolic resistance in mouse skeletal muscle. Biochemical and Biophysical Research Communications, 468 (4), 702-707. doi: 10.1016/j.bbrc.2015.11.019 Damaskos, S., Aartman, I.H.A., Tsiklakis, K., van der Stelt, P. & Berkhout, W.E.R. (2015). Association between extra- and intracranial calcifications of the internal carotid artery: a CBCT imaging study. Dentomaxillofacial Radiology, 44 (5):20140432. doi: 10.1259/dmfr.20140432 Damaskos, S., Tsiklakis, K., Syriopoulos, K. & van der Stelt, P. (2015). Extra- and intra-cranial arterial calcifications in adults depicted as incidental findings on cone beam CT images. Acta Odontologica Scandinavica, 73 (3), 202-209. doi: 10.3109/00016357.2014.979867 De Knegt, N., Defrin, R., Schuengel, C., Lobbezoo, F., Evenhuis, H. & Scherder, E. (2015). Quantitative sensory testing of temperature, pain, and touch in adults with Down syndrome. Research in Developmental Disabilities, 47, 306-317. doi: 10.1016/j.ridd.2015.08.016 De Kok, P., Kleverlaan, C.J., De Jager, N., Kuijs, R. & Feilzer, A.J. (2015). Mechanical performance of implant- supported posterior crowns. Journal of Prosthetic Dentistry, 114 (1), 59-66. doi: 10.1016/j.prosdent.2014.10.015 De Vries, T.J., Schoenmaker, T., Aerts, D., Grevers, L.C., Souza, P.P.C., Nazmi, K., van de Wiel, M.A., Ylstra, B., van Lent, P.L., Leenen, P.J.M. & Everts, V. (2015). M-CSF priming of osteoclast precursors can cause osteoclastogenesis-insensitivity, which can be prevented and overcome on bone. Journal of Cellular Physiology, 230 (1), 210-225. doi: 10.1002/jcp.24702 Deng, S., Wang, Y., Sun, W., Chen, H. & Wu, G. (2015). Scaling and root planning, and locally delivered minocycline reduces the load of Prevotella intermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial. Therapeutics and Clinical Risk Management, 11, 1795-1803. doi: 10.2147/TCRM.S93982 Dicker, G.J., Castelijns, J.A., Tuinzing, D.B. & Stoelinga, P.J.W. (2015). Do the changes in muscle mass, muscle direction, and rotations of the condyles that occur after sagittal split advancement osteotomies play a role in the aetiology of progressive condylar resorption? International Journal of Oral and Maxillofacial Surgery, 44 (5), 627-631. doi: 10.1016/j.ijom.2015.01.001 Dubois, L., Essig, H., Schreurs, R., Jansen, J., Maal, T.J.J., Gooris, P.J.J. & Becking, A.G. (2015). Predictability in orbital reconstruction. A human cadaver study, part III: Implant-oriented navigation for optimized reconstruction. Journal of Cranio-Maxillofacial Surgery, 43 (10), 2050-2056. doi: 10.1016/j.jcms.2015.08.014 Dubois, L., Jansen, J., Schreurs, R., Saeed, P., Beenen, L., Maal, T.J.J., Gooris, P.J.J. & Becking, A.G. (2015). Predictability in orbital reconstruction: A human cadaver study. Part I: Endoscopic assisted orbital reconstruction. Journal of Cranio-Maxillofacial Surgery, 43 (10), 2034-2041. doi: 10.1016/j.jcms.2015.07.019 Dubois, L., Schreurs, R., Jansen, J., Maal, T.J.J., Essig, H., Gooris, P.J.J. & Becking, A.G. (2015). Predictability in orbital reconstruction: A human cadaver study. Part II: Navigation assisted orbital reconstruction. Journal of Cranio-Maxillofacial Surgery, 43 (10), 2042-2049. doi: 10.1016/j.jcms.2015.07.020 Dubois, L., Steenen, S.A., Gooris, P.J.J., Mourits, M.P. & Becking, A.G. (2015). Controversies in orbital reconstruction I. Defect driven orbital reconstruction: a systematic review. International Journal of Oral and Maxillofacial Surgery, 44 (3), 308-315. doi: 10.1016/j.ijom.2014.12.002 Dubois, L., Steenen, S.A., Gooris, P.J.J., Mourits, M.P. & Becking, A.G. (2015). Controversies in orbital reconstruction II. Timing of post traumatic orbital reconstruction: a systematic review. International Journal of Oral and Maxillofacial Surgery, 44 (4), 433-440. doi: 10.1016/j.ijom.2014.12.003 Elmi, P., Reitsma, J.H., Buschang, P.H., Wolvius, E.B. & Ongkosuwito, E.M. (2015). Mandibular asymmetry in patients with the Crouzon or Apert Syndrome. Cleft Palate-Craniofacial Journal, 52 (3), 327-335. doi: 10.1597/13-143 Fahlgren, A., Bratengeier, C., Gelmi, A., Semeins, C.M., Klein-Nulend, J., de Jager, E.W.H. & Bakker, A.D. (2015). Biocompatibility of polypyrrole with human primary osteoblasts and the effect of dopants. PLoS One, 10 (7):e0134023. doi: 10.1371/journal.pone.0134023 Farré-Guasch, E., Wolff, J., Helder, M.N., Schulten, E.A.J.M., Forouzanfar, T. & Klein-Nulend, J. (2015). Application of additive manufacturing in oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery, 73 (12), 2408-2418. doi: 10.1016/j.joms.2015.04.019

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Fernandes, G., van Selms, M.K.A., Gonçalves, D.A.G., Lobbezoo, F. & Camparis, C.M. (2015). Factors associated with temporomandibular disorders pain in adolescents. Journal of Oral Rehabilitation, 42 (2), 113-119. doi: 10.1111/joor.12238 Frank, M.H., Ravesloot, M.J.L., van Maanen, J.P., de Lange, J., de Vries, N. & Verhagen, E. (2015). Positional OSA part 1: towards a clinical classification system for position dependent obstructive sleep apnoea. Sleep and Breathing, 19 (2), 473-480. doi: 10.1007/s11325-014-1022-9 Glim, J.E., Beelen, R.H.J., Niessen, F.B., Everts, V. & Ulrich, M.M.W. (2015). The number of immune cells is lower in healthy oral mucosa compared to skin and does not increase after scarring. Archives of Oral Biology, 60 (2), 272-281. doi: 10.1016/j.archoralbio.2014.10.008 Guo, J., Lyaruu, D.M., Takano, Y., Gibson, C.W., Denbesten, P.K. & Bronckers, A.L. (2015). Amelogenins as potential buffers during secretory-stage amelogenesis. Journal of Dental Research, 94 (3), 412-420. doi: 10.1177/0022034514564186 Hämmerle, C.H.F., Cordaro, L., van Assche, N., Benic, G.I., Bornstein, M., Gamper, F., Gotfredsen, K., Harris, D., Hürzeler, M., Jacobs, R., Kapos, T., Kohal, R.J., Patzelt, S.B., Sailer, I., Tahmaseb, A., Vercruyssen, M. & Wismeijer, D. (2015). Digital technologies to support planning, treatment, and fabrication processes and outcome assessments in implant dentistry: summary and consensus statements: the 4th EAO consensus conference 2015. Clinical Oral Implants Research, 26 (11), 97-101. doi: 10.1111/clr.12648 Hichijo, N., Tanaka, E., Kawai, N., van Ruijven, L.J. & Langenbach, G.E.J. (2015). Effects of decreased occlusal loading during growth on the mandibular bone characteristics. PLoS One, 10 (6):e0129290. doi: 10.1371/journal.pone.0129290 Hoogeveen, R.C., Martens, E.P., van der Stelt, P.F. & Berkhout, W.E.R. (2015). Assessment of random error in phantom dosimetry with the use of error simulation in statistical software. BioMed Research International, 2015:596858. doi: 10.1155/2015/596858 Hoogeveen, R.C., Rottke, D., van der Stelt, P.F. & Berkhout, W.E.R. (2015). Dose reduction in orthodontic lateral cephalography: dosimetric evaluation of a novel cephalographic thyroid protector (CTP) and anatomical cranial collimation (ACC). Dentomaxillofacial Radiology, 44 (4):20140260. doi: 10.1259/dmfr.20140260 Hoogeveen, R.C., Sanderink, G.C.H., van der Stelt, P.F. & Berkhout, W.E.R. (2015). Reducing an already low dental diagnostic X-ray dose: does it make sense? Comparison of three cost-utility analysis methods used to assess two dental dose-reduction measures. Dentomaxillofacial Radiology, 44 (9):20150158. doi: 10.1259/dmfr.20150158 Jalali, R., Zandieh-Doulabi, B., DenBesten, P.K., Seidler, U., Riederer, B., Wedenoja, S., Micha, D. & Bronckers, A.L.J.J. (2015). Slc26a3/Dra and Slc26a6 in murine ameloblasts. Journal of Dental Research, 94 (12), 1732- 1739. doi: 10.1016/j.joms.2015.04.019 Jongsma, L.A. & Kleverlaan, C.J. (2015). Influence of temperature on volumetric shrinkage and contraction stress of dental composites. Dental Materials, 31 (6), 721-725. doi: 10.1016/j.dental.7015.03.009 Keulemans, F., Shinya, A., Lassila, L.V.J., Vallittu, P.K., Kleverlaan, C.J., Feilzer, A.J. & de Moor, R.J.G. (2015). Three-dimensional finite element analysis of anterior two-unit cantilever resin-bonded fixed dental prostheses. The Scientific World Journal, 2015:864389. doi: 10.1155/2015/864389 Klein-Nulend, J., van Oers, R.F.M., Bakker, A.D. & Bacabac, R.G. (2015). Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis. Journal of Biomechanics, 48 (5), 855-865. doi: 10.1016/j.jbiomech.2014.12.007 Koivisto, J., Kiljunen, T., Kadesjö, N., Shi, X.Q. & Wolff, J. (2015). Effective radiation dose of a MSCT, two CBCT and one conventional radiography device in the ankle region. Journal of Foot and Ankle Research, 8:8. doi: 10.1186/s13047-015-0067-8 Koivisto, J.H., Wolff, J.E., Kiljunen, T., Schulze, D. & Kortesniemi, M. (2015). Characterization of MOSFET dosimeters for low-dose measurements in maxillofacial anthropomorphic phantoms. Journal of Applied Clinical Medical Physics, 16 (4), 266-278. doi: 10.1120/jacmp.v16i4.5433 Kommers, S.C., Boffano, P. & Forouzanfar, T. (2015). Consensus or controversy? The classification and treatment decision-making by 491 maxillofacial surgeons from around the world in three cases of a unilateral mandibular condyle fracture. Journal of Cranio-Maxillofacial Surgery, 43 (10), 1952-1960. doi: 10.1016/j.jcms.2015.08.031 Koopman, J.E., van der Kaaij, N.C.W., Buijs, M.J., Elyassi, Y., van der Veen, M.H., Crielaard, W., ten Cate, J.M. & Zaura, E. (2015). The effect of fixed orthodontic appliances and fluoride mouthwash on the oral microbiome of adolescents: a randomized controlled clinical trial. PLoS One, 10 (9):e0137318. doi: 10.1371/journal.pone.0137318

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Kosten, I.J., Buskermolen, J.K., Spiekstra, S.W., de Gruijl, T.D. & Gibbs, S. (2015). Gingiva equivalents secrete negligible amounts of key chemokines involved in Langerhans cell migration compared to skin equivalents. Journal of Immunology Research, 2015:627125. doi: 10.1155/2015/627125 Kosten, I.J., Spiekstra, S.W., de Gruijl, T.D. & Gibbs, S. (2015). MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure. Toxicology and Applied Pharmacology, 287 (1), 35-42. doi: 10.1016/j.taap.2015.05.017 Kroeze, R.J., Smit, T.H., Vergroesen, P.P., Bank, R.A., Stoop, R., van Rietbergen, B., van Royen, B.J. & Helder, M.N. (2015). Spinal fusion using adipose stem cells seeded on a radiolucent cage filler: a feasibility study of a single surgical procedure in goats. European Spine Journal, 24 (5), 1031-1042. doi: 10.1007/s00586-014- 3696-x Kumar, V.V., Ebenezer, S. & Lobbezoo, F. (2015). Long standing intra oral acid burn. Dental hygiene Oral Surgery, 14 (Suppl 1), S190-S194. doi: 10.1007/s12663-012-0411-5 Kumar, V.V., Malik, N.A., Visscher, C.M., Ebenezer, S., Sagheb, K. & Lobbezoo, F. (2015). Comparative evaluation of thickness of jaw-closing muscles in patients with long-standing bilateral temporomandibular joint ankylosis: a retrospective case-controlled study. Clinical Oral Investigations, 19 (2), 421-427. doi: 10.1007/s00784-014-1246-x Lin, X., de Groot, K., Wang, D., Hu, Q., Wismeijer, D. & Liu, Y. (2015). A review paper on biomimetic calcium phosphate coatings. The Open Biomedical Engineering Journal, 9 (Suppl 1-M4), 56-64. doi: 10.2174/1874120701509010056 Liu, J., Zhang, H., Dong, Y., Jin, Y., Hu, X., Cai, K., Ma, J. & Wu, G. (2014). Bi-directionally selective bone targeting delivery for anabolic and antiresorptive drugs: a novel combined therapy for osteoporosis? Medical Hypotheses, 83 (6), 694-696. doi: 10.1016/j.mehy.2014.09.020 Liu, T., Wu, G., Gu, Z., Wismeijer, D. & Liu, Y. (2014). A critical-sized bone defect. Bone, 68, 163-164. doi: 10.1016/j.bone.2014.07.016 Liu, T., Wu, G., Zheng, Y., Wismeijer, D., Everts, V. & Liu, Y. (2014). Cell-mediated BMP-2 release from a novel dual-drug delivery system promotes bone formation. Clinical Oral Implants Research, 25 (12), 1412-1421. doi: 10.1111/clr.12283 Liu, Y., Bao, C., Wismeijer, D. & Wu, G. (2015). The physicochemical/biological properties of porous tantalum and the potential surface modification techniques to improve its clinical application in dental implantology. Materials Science & Engineering C-Materials for Biological Applications, 49, 323-329. doi: 10.1016/j.msec.2015.01.007 Lou, W., Dong, Y., Zhang, H., Jin, Y., Hu, X., Ma, J., Liu, J. & Wu, G. (2015). Preparation and characterization of lanthanum-incorporated hydroxyapatite coatings on titanium substrates. International Journal of Molecular Sciences, 16 (9), 21070-21086. doi: 10.3390/ijms160921070 Ma, J., van den Beucken, J.J.J.P., Both, S.K., Prins, H-J., Helder, M.N., Yang, F. & Jansen, J.A. (2015). Osteogenic capacity of human BM-MSCs, AT-MSCs and their co-cultures using HUVECs in FBS and PL supplemented media. Journal of Tissue Engineering and Regenerative Medicine, 9 (7), 779-788. doi: 10.1002/term.1704 Ma, J., Yang, F., Both, S.K., Prins, H-J., Helder, M.N., Pan, J., Cui, F.Z., Jansen, J.A. & van den Beucken, J.J.J.P. (2015). Bone forming capacity of cell- and growth factor-based constructs at different ectopic implantation sites. Journal of Biomedical Materials Research Part A, 103 (2), 439-450. doi: 10.1002/jbm.a.35192 Manfredini, D., Ahlberg, J., Mura, R. & Lobbezoo, F. (2015). Bruxism is unlikely to cause damage to the periodontium: findings from a systematic literature assessment. Journal of Periodontology, 86 (4), 546-555. doi: 10.1902/jop.2014.140539 Manfredini, D., Ahlberg, J., Winocur, E. & Lobbezoo, F. (2015). Management of sleep bruxism in adults: a qualitative systematic literature review. Journal of Oral Rehabilitation, 42 (11), 862-874. doi: 10.1111/joor.12322 Manfredini, D., Guarda-Nardini, L., Marchese-Ragona, R. & Lobbezoo, F. (2015). Theories on possible temporal relationships between sleep bruxism and obstructive sleep apnea events: an expert opinion. Sleep and Breathing, 19 (4), 1459-1465. doi: 10.1007/s11325-015-1163-5 Manokawinchoke, J., Limjeerajarus, N., Limjeerajarus, C., Sastravaha, P., Everts, V. & Pavasant, P. (2015). Mechanical force-induced TGFBI increases expression of SOST/POSTN by hPDL cells. Journal of Dental Research, 94 (7), 983-989. doi: 10.1177/0022034515581372 Mensink, G., Gooris, P., Mulder, F., Gooris-Kuipers, C. & van Merkestyn, R. (2015). Experiencing your own orthognathic surgery: a personal case report. The Angle Orthodontist, 85 (5), 890-896. doi: 10.2319/062414-453.1

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Meursinge Reynders, R., Ladu, L., Ronchi, L., di Girolama, N., de Lange, J., Roberts, N. & Plüddemann, A. (2015). Insertion torque recordings for the diagnosis of contact between orthodontic mini implants and dental roots: protocol for a systematic review. Systematic Reviews, 4:39. doi: 10.1186/s13643-015-0014-6 Milheiro, A., de Jager, N., Feilzer, A.J. & Kleverlaan, C.J. (2015). In vitro debonding of orthodontic retainers analyzed with finite element analysis. European Journal of Orthodontics, 37 (5), 491-496. doi: 10.1093/ejo/cju074 Milheiro, A., Muris, J., Kleverlaan, C.J. & Feilzer, A.J. (2015). Influence of shape and finishing on the corrosion of palladium-based dental alloys. The Journal of Advanced Prosthodontics, 7 (1), 56-61. doi: 10.4047/jap.2015.7.1.56 Mirmohammadi, H., Mahdi, L., Partovi, P., Khademi, A., Shemesh, H. & Hassan, B. (2015). Accuracy of conebeam computed tomography in the detection of a second mesiobuccal root canal in endodontically treated teeth: an ex vivo study. The Journal of Endodontics, 41 (10), 1678-1681. doi: 10.1016/j.joen.2015.06.011 Moinzadeh, A.T., Jongsma, L.A. & Wesselink, P.R. (2015). Considerations about the use of the "push-out" test in Endodontic research. International Endodontic Journal, 48 (5), 498-500. doi: 10.1111/iej.12416 Mosmuller, D.G.M., Bijnen, C.L., Kramer, G.J.C., Disse, M.A., Prahl, C., Kuik, D.J., Niessen, F.B. & Don Griot, J.P.W. (2015). The Asher-McDade aesthetic index comparison with two scoring systems in nonsyndromic complete unilateral cleft lip and palate patients. The Journal of Craniofacial Surgery, 26 (4), 1242-1245. doi: 10.1097/SCS.0000000000001784 Mosnegutu, A., Wismeijer, D. & Geraets, W. (2015). Implant-supported mandibular overdentures can minimize mandibular bone resorption in edentulous patients: results of a long-term radiologic evaluation. International Journal of Oral & Maxillofacial Implants, 30 (6), 1378-1386. doi: 10.11607/jomi.4009 Muris, J., Goossens, A., Gonçalo, M., Bircher, A.J., Giménez-Arnau, A., Foti, C., Rustemeyer, T., Feilzer, A.J. & Kleverlaan, C.J. (2015). Sensitization to palladium and nickel in Europe and the relationship with oral disease and dental alloys. Contact Dermatitis, 72 (5), 286-296. doi: 10.1111/cod.12327 Muris, J., Goossens, A., Gonçalo, M., Bircher, A.J., Giménez-Arnau, A., Foti, C., Bruze, M., Andersen, K.E., Rustemeyer, T., Feilzer, A.J. & Kleverlaan, C.J. (2015). Sensitization to palladium in Europe. Contact Dermatitis, 72 (1), 11-19. doi: 10.1111/cod.12295 Narra, N., Antalainen, A.K., Zipprich, H., Sándor, G.K. & Wolff, J. (2015). Microcomputed tomography-based assessment of retrieved dental implants. International Journal of Oral & Maxillofacial Implants, 30 (2), 308- 314. doi: 10.11607/jomi.3756 Nolte, J.W., Karssemakers, L.H.E., Grootendorst, D.C., Tuinzing, D.B. & Becking, A.G. (2015). Panoramic imaging is not suitable for quantitative evaluation, classification, and follow up in unilateral condylar hyperplasia. British Journal of Oral & Maxillofacial Surgery, 53 (5), 446-450. doi: 10.1016/j.bjoms.2015.02.014 Noverraz, R.L.M., Disse, M.A., Ongkosuwito, E.M., Kuijpers-Jagtman, A.M. & Prahl, C. (2015). Transverse dental arch relationship at 9 and 12 years in children with unilateral cleft lip and palate treated with infant orthopedics: a randomized clinical trial (DUTCHCLEFT). Clinical Oral Investigations, 19 (9), 2255-2265. doi: 10.1007/s00784-015-1451-2 Oomens, M.A.E.M. & Forouzanfar, T. (2015). Pharmaceutical management of trigeminal neuralgia in the elderly. Drugs & Aging, 32 (9), 717-726. doi: 10.1007/s40266-015-0293-6 Osiewicz, M.A., Werner, A., Pytko-Polonczyk, J., Roeters, F.J.M. & Kleverlaan, C.J. (2015). Contact- and contact-free wear between various resin composites. Dental Materials, 31 (2), 134-140. doi: 10.1016/j.dental.2014.11.007 Osman, R.B. & Swain, M.V. (2015). A critical review of dental implant materials with an emphasis on titanium versus zirconia. Materials, 8 (3), 932-958. doi: 10.3390/ma8030932 Parsa, A., Ibrahim, N., Hassan, B., van der Stelt, P. & Wismeijer, D. (2015). Bone quality evaluation at dental implant site using multislice CT, micro-CT, and cone beam CT. Clinical Oral Implants Research, 26 (1), e1-e7. doi: 10.1111/clr.12315 Pathak, J.L., Bakker, A.D., Verschueren, P., Lems, W.F., Luyten, F.P., Klein-Nulend, J. & Bravenboer, N. (2015). CXCL8 and CCL20 enhance osteoclastogenesis via modulation of cytokine production by human primary osteoblasts. PLoS One, 10 (6):e0131041. doi: 10.1371/journal.pone.0131041 Pathak, J.L., Bravenboer, N., Luyten, F.P., Verschueren, P., Lems, W.F., Klein-Nulend, J. & Bakker, A.D. (2015). Mechanical loading reduces inflammation-induced human osteocyte-to-osteoclast communication. Calcified Tissue International, 97 (2), 169-178. doi: 10.1007/s00223-015-9999-z Pereira, G.K.R., Amaral, M., Cesar, P.F., Bottino, M.C., Kleverlaan, C.J. & Valandro, L.F. (2015). Effect of low- temperature aging on the mechanical behavior of ground Y-TZP. Journal of the Mechanical Behavior of Biomedical Materials, 45, 183-192. doi: 10.1016/j.jmbbm.2014.12.009

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Potočňáková, L., Šperka, J., Zikán, P., van Loon, J.J.W.A., Beckers, J. & Kudrle, V. (2015). Gravity effects on a gliding arc in four noble gases: from normal to hypergravity. Plasma Sources Science & Technology, 24 (2):022002. doi: 10.1088/0963-0252/24/2/022002 Rachmawati, D., Alsalem, I.W.A., Bontkes, H.J., Verstege, M.I., Gibbs, S., von Blomberg, B.M.E., Scheper, R.J. & van Hoogstraten, I.M.W. (2015). Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury). Toxicology in Vitro, 29 (2), 363-369. doi: 10.1016/j.tiv.2014.10.010 Rachmawati, D., Buskermolen, J.K., Scheper, R.J., Gibbs, S., von Blomberg, B.M.E. & van Hoogstraten, I.M.W. (2015). Dental metal-induced innate reactivity in keratinocytes. Toxicology in Vitro, 30 (1, Part B), 325-330. doi: 10.1016/j.tiv.2015.10.003 Rachmawati, D., Muris, J., Scheper, R.J., Rustemeyer, T., Kleverlaan, C.J., Feilzer, A.J.,vVon Blomberg, B.M.E. & van Hoogstraten, I.M.W. (2015). Continuing the quest for autoimmunity due to oral metal exposure. Autoimmunity, 48 (7), 494-501. doi: 10.3109/08916934.2015.1033688 Reijnders, C.M.A., van Lier, A., Roffel, S., Kramer, D., Scheper, R.J. & Gibbs, S. (2015). Development of a full- thickness human skin equivalent in vitro model derived from TERT-immortalized keratinocytes and fibroblasts. Tissue Engineering. Part A, 21 (17-18), 2448-2459. doi: 10.1089/ten.tea.2015.0139 Reisinger, K., Hoffmann, S., Alépée, N., Ashikaga, T., Barroso, J., Elcombe, C., Gellatly, N., Galbiati, V., Gibbs, S., Groux, H., Hibatallah, J., Keller, D., Kern, P., Klaric, M., Kolle, S., Kuehnl, J., Lambrechts, N., Lindstedt, M., Millet, M., Martinozzi-Teissier, S., Natsch, A., Petersohn, D., Pike, I., Sakaguchi, H., Schepky, A., Tailhardat, M., Templier, M., van Vliet, E & Maxwell, G. (2015). Systematic evaluation of non-animal test methods for skin sensitisation safety assessment. Toxicology in Vitro, 29 (1), 259-270. doi: 10.1016/j.tiv.2014.10.018 Ridwan-Pramana, A., Wolff, J., Raziei, A., Ashton-James, C.E. & Forouzanfar, T. (2015). Porous polyethylene implants in facial reconstruction: outcome and complications. Journal of Cranio-Maxillofacial Surgery, 43 (8), 1330-1334. doi: 10.1016/j.jcms.2015.06.022 Rocca, G.T., Saratti, C.M., Cattani-Lorente, M., Feilzer, A.J., Scherrer, S. & Krecji, I. (2015). The effect of a fiber reinforced cavity configuration on load bearing capacity and failure mode of endodontically treated molars restored with CAD/CAM resin composite overlay restorations. Journal of Dentistry, 43 (9), 1106-1115. doi: 10.1016/j.jdent.2015.06.012 Ruslin, M., Wolff, J., Boffano, P., Brand, H.S. & Forouzanfar, T. (2015). Dental trauma in association with maxillofacial fractures: an epidemiological study. Dental Traumatology, 31 (4), 318-323. doi: 10.1111/edt.12176 Salehi-Nik, N., Amoabediny, G., Shokrgozar, M.A., Mottaghy, K., Klein-Nulend, J. & Zandieh-Doulabi, B. (2015). Surface modification of silicone tubes by functional carboxyl and amine, but not peroxide groups followed by collagen immobilization improves endothelial cell stability and functionality. Biomedical Materials, 10 (1):015024. doi: 10.1088/1748-6041/10/1/015024 Santing, H.J., Kleverlaan, C.J., Werner, A., Feilzer, A.J., Raghoebar, G.M. & Meijer, H.J.A. (2015). Occlusal wear of provisional implant-supported restorations. Clinical Implant Dentistry and Related Research, 17 (1), 179- 185. doi: 10.1111/cid.12072 Scherder, E.J.A., Plooij, B., Achterberg, W.P., Pieper, M., Wiegersma, M., Lobbezoo, F. & Oosterman, J.M. (2015). Chronic pain in "probable" vascular dementia: preliminary findings. Pain Medicine, 16 (3), 442-450. doi: 10.1111/pme.12637 Sokos, D., Everts, V. & de Vries, T.J. (2015). Role of periodontal ligament fibroblasts in osteoclastogenesis: a review. Journal of Periodontal Research, 50 (2), 152-159. doi: 10.1111/jre.12197 Svensson, P., Michelotti, A., Lobbezoo, F. & List, T. (2015). The many faces of persistent orofacial muscle pain. Journal of Oral & Facial Pain and Headache, 29 (2), 207-208. Szulcek, R., van Bezu, J., Boonstra, J., van Loon, J.J.W.A. & van Nieuw Amerongen, G.P. (2015). Transient intervals of hyper-gravity enhance endothelial barrier integrity: impact of mechanical and gravitational forces measured electrically. PLoS One, 10 (12):e0144269. doi: 10.1371/journal.pone.0144269 Ten Harkel, B., Schoenmaker, T., Picavet, D.I., Davison, N.L., de Vries, T.J. & Everts, V. (2015). The foreign body giant cell cannot resorb bone, but dissolves hydroxyapatite like osteoclasts. PLoS One, 10 (10):e0139564. doi: 10.1371/journal.pone.0139564 Valiente López, M., van Selms, M.K.A., van der Zaag, J., Hamburger, H.L. & Lobbezoo, F. (2015). Do sleep hygiene measures and progressive muscle relaxation influence sleep bruxism? Report of a randomised controlled trial. Journal of Oral Rehabilitation, 42 (4), 259-265. doi: 10.1111/joor.12252 Van den Bergh, B., Blankestijn, J., van der Ploeg, T., Tuinzing, D.B. & Forouzanfar, T. (2015). Conservative treatment of a mandibular condyle fracture: comparing intermaxillary fixation with screws or arch bar. A randomised clinical trial. Journal of Cranio-Maxillofacial Surgery, 43 (5), 671-676. doi: 10.1016/j.jcms.2015.03.010

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Van den Bergh, B., de Mol van Otterloo, J.J., van der Ploeg, T., Tuinzing, D.B. & Forouzanfar, T. (2015). IMF- screws or arch bars as conservative treatment for mandibular condyle fractures: quality of life aspects. Journal of Cranio-Maxillofacial Surgery, 43 (7), 1004-1009. doi: 10.1016/j.jcms.2015.05.009 Van den Broek, L.J., van der Veer, W.M., de Jong, E.H., Gibbs, S. & Niessen, F.B. (2015). Suppressed inflammatory gene expression during human hypertrophic scar compared to normotrophic scar formation. Experimental Dermatology, 24 (8), 623-629. doi: 10.1111/exd.12739 Van der Kaaij, N.C.W., van der Veen, M.H., van der Kaaij, M.A.E. & ten Cate, J.M. (2015). A prospective, randomized placebo-controlled clinical trial on the effects of a fluoride rinse on white spot lesion development and bleeding in orthodontic patients. European Journal of Oral Sciences, 123 (3), 186-193. doi: 10.1111/eos.12186 Van der Velden, U., Koster, T.J.G., Feilzer, A.J., Timmerman, M.F. & van der Weijden, G.A. (2015). In vitro evaluation of temperature changes in the root canal induced by ultrasonic scalers. International Journal of Dental Hygiene, 13 (2), 132-137. doi: 10.1111/idh.12084 Van der Zande, M.M., Gorter, R.C., Aartman, I.H.A. & Wismeijer, D. (2015). Adoption and use of digital technologies among general dental practitioners in the Netherlands. PLoS One, 10 (3):e0120725. doi: 10.1371/journal.pone.0120725 Van Eekeren, P., Said, C., Tahmaseb, A. & Wismeijer, D. (2015). Resonance frequency analysis of thermal acid- etched, hydrophilic implants during first 3 months of healing and osseointegration in an early-loading protocol. International Journal of Oral & Maxillofacial Implants, 30 (4), 843-850. doi: 10.11607/jomi.3985 Van Houtem, C.M.H.H., van Wijk, A.J., Boomsma, D.I., Ligthart, L., Visscher, C.M. & de Jongh, A. (2015). Self- reported gagging in dentistry: prevalence, psycho-social correlates and oral health. Journal of Oral Rehabilitation, 42 (7), 487-494. doi: 10.1111/joor.12289 Van Kooten, J., Delwel, S., Binnekade, T.T., Smalbrugge, M., van der Wouden, J.C., Perez, R.S.G.M., Rhebergen, D., Zuurmond, W.W.A., Stek, M.L., Lobbezoo, F., Hertogh, C.M.P.M. & Scherder, E.J.A. (2015). Pain in dementia: prevalence and associated factors: protocol of a multidisciplinary study. BMC Geriatrics, 15 (1):29. doi: 10.1186/s12877-015-0025-0 Van Oers, R.F.M. & Feilzer, A.J. (2015). Abutment-to-fixture load transfer and peri-implant bone stress. American Journal of Dentistry, 28 (5), 247-250. Van Oers, R.F.M., Wang, H. & Bacabac, R.G. (2015). Osteocyte shape and mechanical loading. Current Osteoporosis Report, 13 (2), 61-66. doi: 10.1007/s11914-015-0256-1 Van Velzen, F.J.J., Ofec, R., Schulten, E.A.J.M. & ten Bruggenkate, C.M. (2015). 10-year survival rate and the incidence of peri-implant disease of 374 titanium dental implants with a SLA surface: a prospective cohort study in 177 fully and partially edentulous patients. Clinical Oral Implants Research, 26 (10), 1121-1128. doi: 10.1111/clr.12499 Van Wezel, N.A., Bos, A. & Prahl, C. (2015). Expectations of treatment and satisfaction with dentofacial appearance in patients applying for orthodontic treatment. American Journal of Orthodontics and Dentofacial Orthopedics, 147 (6), 698-703. doi: 10.1016/j.ajodo.2015.01.024 Verlinden, C.R.A., van de Vijfeijken, S.E.C.M., Jansma, E.P., Becking, A.G. & Swennen, G.R.J. (2015). Complications of mandibular distraction osteogenesis for congenital deformities: a systematic review of the literature and proposal of a new classification for complications. International Journal of Oral and Maxillofacial Surgery, 44 (1), 37-43. doi: 10.1016/j.ijom.2014.07.009 Verlinden, C.R.A., van de Vijfeijken, S.E.C.M., Tuinzing, D.B., Becking, A.G. & Swennen, G.R.J. (2015). Complications of mandibular distraction osteogenesis for acquired deformities: a systematic review of the literature. International Journal of Oral and Maxillofacial Surgery, 44 (8), 956-964. doi: 10.1016/j.ijom.2014.12.008 Verlinden, C.R.A., van de Vijfeijken, S.E.C.M., Tuinzing, D.B., Jansma, E.P., Becking, A.G. & Swennen, G.R.J. (2015). Complications of mandibular distraction osteogenesis for developmental deformities: a systematic review of the literature. International Journal of Oral and Maxillofacial Surgery, 44 (1), 44-49. doi: 10.1016/j.ijom.2014.09.007 Vervoorn-Vis, G.M.G.J., Wetselaar, P., Koutris, M., Visscher, C.M., Evälahti, M., Ahlberg, J. & Lobbezoo, F. (2015). Assessment of the progression of tooth wear on dental casts. Journal of Oral Rehabilitation, 42 (8), 600-604. doi: 10.1111/joor.12292 Visscher, C.M. & Lobbezoo, F. (2015). The evolution of thinking about temporomandibular pain. The Journal of the American Dental Association, 146 (12), 925-926. doi: 10.1016/j.adaj.2015.01.016 Visscher, C.M. & Lobbezoo, F. (2015). TMD pain is partly heritable: a systematic review of family studies and genetic association studies. Journal of Oral Rehabilitation, 42 (5), 386-399. doi: 10.1111/joor.12263

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Visscher, C.M., Ligthart, L., Schuller, A.A., Lobbezoo, F., de Jongh, A., van Houtem, C.M.H.H. & Boomsma, D.I. (2015). Comorbid disorders and sociodemographic variables in temporomandibular pain in the general Dutch population. Journal of Oral & Facial Pain and Headache, 29 (1), 51-59. doi: 10.11607/ofph.1324 Weijenberg, R.A.F. & Lobbezoo, F. (2015). Chew the pain away: oral habits to cope with pain and stress and to stimulate cognition. BioMed Research International, 2015:149431. doi: 10.1155/2015/149431 Weijenberg, R.A.F., Lobbezoo, F., Visscher, C.M. & Scherder, E.J.A. (2015). Oral mixing ability and cognition in elderly persons with dementia: a cross-sectional study. Journal of Oral Rehabilitation, 42 (7), 481-486. doi: 10.1111/joor.12283 Wetselaar, P., Koutris, M., Visscher, C.M., Larsson, P., John, M.T. & Lobbezoo, F. (2015). Psychometric properties of the Dutch version of the Orofacial Esthetic Scale (OES-NL) in dental patients with and without self-reported tooth wear. Journal of Oral Rehabilitation, 42 (11), 803-809. doi: 10.1111/joor.12314 Wolff, J., Pyysalo, M., Antalainen, A.K., Sándor, G.K. & Helminen, M. (2015). Removal rates of dental implants placed in conjunction with autologous bone and xenogeneic and synthetic alloplastic materials in Finland between 1994 and 2012. Implant Dentistry, 24 (5), 552-556. doi: 10.1097/ID.0000000000000320 Wolff, J., Sándor, G.K., Forouzanfar, T., Schulten, E.A.J.M. & Oikarinen, K.S. (2015). A 22-year follow-up of an endodontic implant. Dental Traumatology, 31 (5), 409-412. doi: 10.1111/edt.12174 Yu, N., Bronckers, A.L.J.J., Oortgiesen, D.A.W., Yan, X., Jansen, J.A., Yang, F. & Walboomers, X.F. (2015). Periodontal cell implantation contributes to the regeneration of the periodontium in an indirect way. Tissue Engineering. Part A, 21 (1-2), 166-173. doi: 10.1089/ten.tea.2014.0151 Zembic, A., Tahmaseb, A. & Wismeijer, D. (2015). Within-subject comparison of maxillary implant-supported overdentures with and without palatal coverage. Clinical Implant Dentistry and Related Research, 17 (3), 570-579. doi: 10.1111/cid.12125 Zhang, X., Guo, J., Wu, G. & Zhou, Y. (2015). Effects of heterodimeric bone morphogenetic protein-2/7 on osteogenesis of human adipose-derived stem cells. Cell Proliferation, 48 (6), 850-860. doi: 10.1111/cpr.12218 Zhang, X., Liu, T., Huang, Y., Zheng, Y., Liu, T., Wismeijer, D. & Liu, Y. (2015). Osteogenic potential of icariin compared with recombinant human bone morphogenetic protein 2 in vitro: a preliminary study. Journal of Biomaterials and Tissue Engineering, 5 (3), 226-233. doi: 10.1166/jbt.2015.1302 Zheng, Y., Wu, G., Liu, T., Liu, Y., Wismeijer, D. & Liu, Y. (2014). A novel BMP2-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particle: a biodegradable and highly efficient osteoinducer. Clinical Implant Dentistry and Related Research, 16 (5), 643-654. doi: 10.1111/cid.12050 Zou, J., Koivisto, J., Lähelmä, J., Aarnisalo, A., Wolff, J. & Pyykkö, I. (2015). Imaging optimization of temporal bones with cochlear implant using a high-resolution cone beam CT and the corresponding effective dose. The Annals of Otology Rhinology & Laryngology, 124 (6), 466-473. doi: 10.1177/0003489414565004 Zou, J., Lähelmä, J., Koivisto, J., Dhanasingh, A., Jolly, C., Aarnisalo, A., Wolff, J. & Pyykkö, I. (2015). Imaging cochlear implantation with round window insertion in human temporal bones and cochlear morphological variation using high-resolution cone beam CT. Acta Oto-Laryngologica, 135 (5), 466-472. doi: 10.3109/00016489.2014.993090

Scientific publications (non refereed) Aarab, G. & Lobbezoo, F. (2015). Dental changes in obstructive sleep apnea patients under oral appliance treatment are progressive in nature. Journal of Dental Sleep Medicine, 2 (2), 35-36. doi: 10.15331/jdsm.4628 Benoist, L.B.L., de Ruiter, M.H.T., de Lange, J. & de Vries, N. (2015). Residual POSA after maxillomandibular advancement in patients with severe OSA. In N. de Vries, M. Ravesloot & J.P. van Maanen (Eds.), Positional therapy in obstructive sleep apnea (pp. 321-329). Cham: Springer International Publishing. Beysens, D.A. & van Loon, J.J.W.A. (2015). The space gravity environment. In D.A. Beysens & J.J.W.A. van Loon (Eds.), Generation and applications of extra-terrestrial environments on earth (The River Publishers Series in Standardisation, 6) (pp. 5-9-1). Aalborg, Denmark: Rivers Publishing. Hasenstein, K.H. & van Loon, J.J.W.A. (2015). Clinostats and other rotating systems: design, function, and limitations. In D.A. Beysens & J.J.W.A. van Loon (Eds.), Generation and applications of extra-terrestrial environments on earth (River Publishers Series in Standardisation, 6) (pp. 147-156). Aalborg, Denmark: River Publishers. Juffer, P., Bakker, A.D., Jaspers, R.T. & Klein-Nulend, J. (2015). Fluid flow in strain and bone. In H. Simpson & P. Augat (Eds.), Experimental research methods in orthopedics and trauma (pp. 291-299). Stuttgart: Thieme.

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Pathak, J.L., Jansen, I.D.C., Bravenboer, N., Klein-Nulend, J. & Bakker, A.D. (2015). Biomechanics of bone cells. In H. Simpson & P. Augat (Eds.), Experimental research methods in orthopedics and trauma (pp. 300-308). Stuttgart: Thieme. Ravesloot, M., Frank, M.H., van Maanen, J.P., Verhagen, E.A., de Lange, J. & de Vries, N. (2015). Towards a clinical classification system for position-dependent obstructive sleep apnea. In N. de Vries, M. Ravesloot & J.P. van Maanen (Eds.), Positional therapy in obstructive sleep apnea (pp. 131-135). Cham: Springer International Publishing. Van Loon, J.J.W.A. (2015). Centrifuges. In D.A. Beysens & J.J.W.A. van Loon (Eds.), Generation and applications of extra-terrestrial environments on earth (River Publishers Series in Standardisation, 6) (pp. 109-119). Aalborg, Denmark: River Publishers. Wang, D., Wu, G., Lin, X. & Liu, Y. (2015). Coatings for osseointegration of metallic biomaterials. In C. Wen (Ed.), Surface coating and modification of metallic biomaterials (Woodhead Publishing Series in Biomaterials) (pp. 345-358). Cambridge: Woodhead Publishing. Wu, G., Guo, J., Hu, H. & Everts, V. (2015). Biological reactions to temporary anchorage devices. In V. Krishan & Z. Davidovitch (Eds.), Biological mechanisms of tooth movement (2nd ed.) (pp. 97-107). Chichester, West Sussex: John Wiley & Sons Inc.

Professional publications Aarab, G. & Lobbezoo, F. (2015). Slaapgerelateerde ademhalingsstoornissen. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 279-296). Houten: Bohn Stafleu van Loghum. Aarab, G., van Selms, M.K.A., Lobbezoo, F. & Visscher, C.M. (2015). Diagnostiek en behandeling van temporomandibulaire pijn: rol van de mondhygiënist. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 8 (1), 17-23. Aarab, G., Wetselaar, P. & Lobbezoo, F. (2015). Begrippen en definities. In F. Lobbezoo & C. de Baat (Eds.), Occlusie en articulatie: wetenschappelijk bewijs en klinisch handelen (pp. 48-61). Houten: Prelum. Akkerman, V., Ho, J.P.T.F., Baas, E.M. & de Lange, J. (2015). Verlenging van de onderkaak: bilaterale sagittale splijtingsosteotomie versus distractieosteogenese. Nederlands Tijdschrift voor Tandheelkunde, 122 (11), 603-608. doi: 10.5177/ntvt.2015.11.15158 Apperloo, R.C. & Rozeboom, A.V.J. (2015). Obstructief slaapapneusyndroom en het mandibulair repositieapparaat. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (3), 42-46. Bakker, A.D. (2015). Verschillen tussen osteoclasten afkomstig van het schedelbot en de lange beenderen [Bespreking van het boek Functional differences between site-specific osteoclasts]. Nederlands Tijdschrift voor Tandheelkunde, 122(7-8), 424. Bakx, S. & Syriopoulos, K. (2015). De tandheelkundige röntgenopname: valkuilen en verrassingen. Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 280-285. doi: 10.5177/ntvt.2015.5.14245 Berkhout, W.E.R. (2015). Het ALARA-principe: achtergronden en toepassing in de praktijk. Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 263-270. doi: 10.5177/ntvt.2015.5.14227 Bijl, D. & Baart, J.A. (2015). Geneesmiddelenbulletin. Nederlands Tandartsenblad, 70 (9), 33. Bijl, D. & Baart, J.A. (2015). Geneesmiddelenbulletin. Nederlands Tandartsenblad, 70 (2), 35. Bijl, D. & Baart, J.A. (2015). Geneesmiddelenbulletin. Nederlands Tandartsenblad, 70 (7), 27. Brand, H. & Baart, J. (2015). Komt een zwangere vrouw bij de tandarts. In I.F. van Panhuizen, M.M.J. Snoeck, G.J. van Geffen & R.R. van der Hulst (Eds.), Probleemgeoriënteerd denken voor gebruikers van lokaal anesthetica: een praktijkboek voor de opleiding en de kliniek (pp. 131-136). Utrecht: De Tijdstroom. Carlsson, G.E., Johansson, A.K., Lobbezoo, F., Roeters, F.J.M., Wetselaar, P. & Johansson, A. (2015). Occlusie en gebitsslijtage. In F. Lobbezoo & C. de Baat (Eds.), Occlusie en articulatie: wetenschappelijk bewijs en klinisch handelen (pp. 62-79). Houten: Prelum. Cossé, J.H.P. (2015). Dento-alveolaire botopbouwen. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (4), 29-35. De Lange, J. (2015). De derde molaar in de onderkaak: preventief verwijderen? Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (3), 17-22. De Lange, J. (2015). Endodontische herbehandeling of apexresectie, een lastige keuze. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (3), 12-16. Derksen, W., Wismeijer, D., Hanssen, S. & Tahmaseb, A. (2015). Dental technician of the future. Forum Implantologicum, 11 (1), 12-20.

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Derksen, W.D.C. (2015). De digitale workflow: welke materialen hebben we beschikbaar in CAD/CAM-kroon- en brugwerk op implantaten? Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (4), 8-15. Dubois, L., van Riet, T.C.T. & Kroon, F.H.M. (2015). Trauma van het aangezicht, meer dan tandletsel. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (3), 23-31. Everts, V. (2015). Basisboek medische celbiologie [Bespreking van het boek Basisboek medische celbiologie]. Nederlands Tijdschrift voor Tandheelkunde, 122(6), 359. Feilzer, A.J., Kleverlaan, C.J., Prahl, C. & Muris, J. (2015). Systemische reacties op metaallegeringen. In N.H.J. Creugers, D.J. Witter & C. de Baat (Eds.), Kronen en bruggen: theoretische uitgangspunten en praktische handreikingen (pp. 258-267). Houten: Prelum. Gibbs, S. (2015). Bijna zoals een echte huid. Linkedin-ZonMw Showcase Translational Research: from bench to bedside. Nederland: Linkedin-ZonMw. (last update: 26 Jan 2016). Gibbs, S., Blok, C.S., van den Broek, L.J., Weijers, E.M., Bergers, L.I.J.C., Limandjaja, G.C., Niessen, F.B., van Montfrans, C. & De Boer, E.M. (2015). Wondgenezing en tissue engineering. Nederlands Tijdschrift voor Dermatologie & Venereologie, 25 (6), 275-278. Hassan, B., Giménez Gonzáles, B., Tahmaseb, A., Jacobs, R. & Bornstein, M.M. (2014). Three-dimensional facial scanning technology: applications and future trends. Forum Implantologicum, 10 (1), 77-86. Hoogeveen, R. (2015). Cone Beam CT bij kaakchirurgische verwijdering verstandskiezen. Imago, 1 (1), 52-53. Hoogeveen, R.C. & van den Aardweg, G.J.M.J. (2015). Radiobiologische aspecten van tandheelkundige röntgendiagnostiek. Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 287-292. doi: 10.5177/ntvt.2015.05.14223 Hopman, A.J.G., Baart, J.A. & Brand, H.S. (2015). Articaïne en neurotoxiciteit. In J.K.M. Aps, M. De Bruyne, R. Jacobs, M.E.L. Nienhuijs & W.J. van der Meer (Eds.), Het tandheelkundig jaar 2016 (pp. 109-122). Houten: Bohn Stafleu van Loghum. Kleverlaan, C.J. & Jongsma, L.A. (2015). Het belang van krimp en krimpspanning. VVT Magazine - Verbond Vlaamse Tandartsen, 4 (3), 413. Kleverlaan, C.J. & Jongsma, L.A. (2015). Het belang van krimp en krimpspanning: effecten tijdens de verharding van composieten. De Tandartspraktijk, 36 (7), 24-27. doi: 10.1007/s12496-015-0099-z Koolstra, J.H. (2015). Anatomie van het kauwstelsel. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 1-15). Houten: Bohn Stafleu van Loghum. Koutris, M. & Linardakou, K. (2015). Vrygmos: mia prokleÌ„̄eÌ„ ̄ia teÌ„n ̄atheÌ„mern̄ eÌ„ klīikeÌ„ prax.̄ Ōontiatriko Vima, 106, 4-6. Koutris, M., Wetselaar, P. & Lobbezoo, F. (2015). Neuropathische pijn. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 8 (1), 25-28. Lobbezoo, F. & Perez, R.S.G.M. (2015). Neurofysiologie van pijn. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 105-128). Houten: Bohn Stafleu van Loghum. Lobbezoo, F. & Visscher, C.M. (2015). Behandeling van temporomandibulaire aandoeningen. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 191-227). Houten: Bohn Stafleu van Loghum. Lobbezoo, F. & Wetselaar, P. (2015). Het hoe en waarom van verwijzen bij aangezichtspijn. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 8 (1), 7-11. Lobbezoo, F. (2015). Bruxisme en andere orale bewegingsstoornissen. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 229-249). Houten: Bohn Stafleu van Loghum. Lobbezoo, F., Toxopeus, A.H., Delwel, S., Weijenberg, R.A.F. & Scherder, E.J.A. (2015). Orofaciale pijndiagnostiek bij ouderen met een dementie. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (2), 12-16. Lobbezoo, F., Wetselaar, P. & van Selms, M.K.A. (2015). De rol van occlusie bij bruxisme. In F. Lobbezoo & C. de Baat (Eds.), Occlusie en articulatie: wetenschappelijk bewijs en klinisch handelen (pp. 34-47). Houten: Prelum. Moinzadeh, A.T., Jongsma, L., Groot-Kuin, D., Neirynck, N., Cristescu, R. & Camilleri, J. (2015). Endodontologie in beweging: nieuwe concepten, materialen en technieken 1. Hydraulische calciumsilicaatcementen. Nederlands Tijdschrift voor Tandheelkunde, 122 (7-8), 405-414. doi: 10.5177/ntvt.2015.07/08.15146 Muris, J. (2015). Diagnostiek van metaalallergie geassocieerd met tandheelkundige restauraties. In J.K.M. Aps, M. de De Bruyne, R. Jacobs, M.E.L. Nienhuijs & W.J. van der Meer (Eds.), Het tandheelkundig jaar 2016 (pp. 147-156). Houten: Bohn Stafleu van Loghum.

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Nolte, J.W. & Becking, A.G. (2015). Eruptiestoornissen en het vrijleggen van geïmpacteerde incisieven, cuspidaten, premolaren en molaren. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (3), 7-11. Oomens, M.A.E.M., Booij, J.H.D. & Baart, J.A. (2015). Gevaar van algehele anesthesie en sedatie bij ouderen. Nederlands Tijdschrift voor Tandheelkunde, 122 (12), 674-679. doi: 10.5177/ntvt.2015.12.15160 Poorterman, J.H.G. (2015). Bedankt voor uw geduld. Nederlands Tijdschrift voor Tandheelkunde, 122 (10), 499. Poorterman, J.H.G. (2015). Indicatie voor en frequentie van intraorale röntgenopnamen. Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 272-278. doi: 10.5177/ntvt.2015.05.14241 Roeters, F.J.M. & Loomans, B.A.C. (2015). Intraorale reparaties en correcties. In N.H.J. Creugers, D.J. Witter & C. de Baat (Eds.), Kronen en bruggen: theoretische uitgangspunten en praktische handreikingen (pp. 246- 256). Houten: Prelum. Roeters, F.J.M. (2015). Tandheelkundige instrumenten [Bespreking van het boek Dental instruments: a pocket guide (5th ed.)]. Nederlands Tijdschrift voor Tandheelkunde, 122(3), 173. Tahmaseb, A., Wismeijer, D. & Derksen, W.D.C. (2015). Guided Surgery in de implantologie: een overzicht. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (4), 17-27. Van der Avoort, G. (2014). Nazorg bij implantaten (AccreDidact. Tandartsen, 3-2014). Houten: AccreDidact. Van der Avoort, P.G.G.L. (2015). Onderhoud van implantaten. Quality Practice. Nascholingstijdschrift voor Tandartsen, 10 (4), 37-44. Van der Maarel-Wierink, C., Lobbezoo, F., Delwel, S. & van der Putten, G.J. (2014). Het belang van een gezonde mond: betere mondzorg bij dementie. Denkbeeld, 27 (1), 26-29. doi: 10.1007/s12428-015-0021-3 Van der Stelt, P.F. (2015). Röntgendiagnostiek in de tandheelkunde. Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 239. Van der Stelt, P.F. (2015). Tandheelkundige radiologie: weten regelgeving. Nederlands Tijdschrift voor Tandheelkunde, 122 (5), 253-258. doi: 10.5177/ntvt.2015.05.14252 Van Doornmalen Gomez Hoyos, J.P.C.M., Rietmeijer, A.G.M., Feilzer, A.J. & Kopinga, K. (2015). Het monitoren van stoomsterilisatieprocessen in de mondzorgpraktijk. Nederlands Tijdschrift voor Tandheelkunde, 122 (4), 218-224. doi: 10.5177/ntvt.2015.04.14258 Van Selms, M.K.A., Attallah, M.M., Visscher, C.M., Ahlberg, J. & Lobbezoo, F. (2015). Does playing a musical instrument impose a risk for temporomandibular disorders? A review of literature: Stellt das Spielen eines Instruments ein Risiko für kraniomandibuläre Dysfunktionen dar? Eine Übersichtsarbeit. Journal of Craniomandibular Function, 7 (4), 293-314. Van Strijp, A.J.P., van Amerongen, J.P., de Kloet, H.J., van Loveren, C., Penning, C., Roeters, F.J.M. & Verhoef, A. (2015). Carieslaesies: diagnose en behandeling (6e geh. herz. druk). Houten: Prelum. Visscher, C.M. & Lobbezoo, F. (2015). Differentiële diagnostiek van orofaciale pijn. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 177-190). Houten: Bohn Stafleu van Loghum. Visscher, C.M. & Lobbezoo, F. (2015). Mondgewoonten - is dat erg? Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 7 (4), 23-26. Visscher, C.M. (2015). Fysiotherapeutische behandeling van kaakklachten. Quality Practice Assistenten, 2 (2), 43-47. Visscher, C.M. (2015). Hoofdpijn bij patiënten in de dagelijkse praktijk. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 8 (1), 29-32. Warnsinck, C.J., Koutris, M., Lobbezoo, F. & Shemesh, H. (2015). Persisterende pijn in het dento-alveolaire gebied. Quality Practice. Nascholingstijdschrift voor Mondhygiënisten, 8 (1), 12-16. Warnsinck, C.J., Koutris, M., Shemesh, H. & Lobbezoo, F. (2015). Persisterende dentoalveolaire pijn (PDAP). Nederlands Tijdschrift voor Tandheelkunde, 122 (2), 95-100. doi: 10.5177/ntvt.2015.02.14189 Wetselaar, P. & Lobbezoo, F. (2015). Diagnostiek van gebitsslijtage (naslagwerk bij online cursus, 44 pp.). Houten: AccreDidact, onafhankelijke geaccrediteerde nascholing. (available: 01 January 2014). Wetselaar, P. & Lobbezoo, F. (2015). Gebitsslijtage. In M. Naeije, F. Lobbezoo & C.M. Visscher (Eds.), Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu (pp. 251-277). Houten: Bohn Stafleu van Loghum.

Patents Wismeijer, D. (2015) Customized dent implant and associated tooling. Nr. 151167007.2-1658, 8 May 2015, VU Amsterdam.

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Grants: current projects with external funding Aarab, G. (2015). NVGPT Research grant (€5.000,-), for a study to the effects of oral appliance therapy on masseter muscle activity in obstructive sleep apnea patients: a randomized controlled trial. (2014, January 01 - 2018, December 31). Aarab, G. (2015). KNAW Project Grant, €26.700,-The role of race in the pathogenesis of obstructive sleep apnea: Asians versus Caucasians. China Exchange Programme: (2016, January 01 - 2018, December 31). Aarab, G. (2015). Research grant (€2.500,-), for a study to the effects of oral appliance therapy on masseter muscle activity in obstructive sleep apnea patients: a randomized controlled trial. American Equilibration Society: (2014, January 01 - 2017, December 31). Becking, A.G. & Kleverlaan, C.J. (2015). CRANIOSAFE: Optimized and innovative materials and customized treatment strategies for cranioplasty. NWO-STW, granted €750.000: (2016, January 01 - 2017, January 01). Benic, G.I., Wismeijer, D., Hassan, B.A., Tahmaseb, A. & Hämmerle, C.H.F. (2015). International Team of Implantologists grant number 1030_2014 for a multi-center study on ceramic implant restorations. ITI (together with Zurich), total amount 160,000 euro: (2015, January 01 - 2015, December 31). Chen, H. (2015). The role of race in the pathogenesis of obstructive sleep apnea: Asians versus Caucasians. KNAW: China Exchange Programme (CEP), Research project in collaboration with Shangdong University and ACTA Oral Kinesiology, Oral Radiology & Oral Maxillofacial Surgery AMC, project number: 530-5CDP12. PhD program during 4 years, financially supported by Grant China Scholarship Council (CSC), granted €26.700,00: (2013, October 01 - 2017, October 01). Deng, D.M. & Wu, G. (2015). Application of a novel local antimicrobial delivery and osteoconductive system on decontaminated implant surfaces to promote re-osseointegration. ITI Foundation research grant, 1034_2014 (Principal investigator) (01-07-2015 till 30-06-2017), granted 37,798 Euro: (2015, July 01 - 2017, July 30). De Lange, J. (2015). Ongoing research in OSA. 4Dental, granted €30.000: (2016, January 01 - 2017, January 01). De Lange, J., de Vries, N. & Lobbezoo, F. (2015). Reinforcing ACTA's focus on dental sleep medicine. SomnoMed Inc., granted €250.000 for 1 parttime AIO and 1 parttime UHD: (2016, January 01 - 2020, January 01). De Oliveira Gamba, T. (2015). Association of two craniometric methods for sexual prediction in CBCT scans. One year scholarship in the context of doctoral research of mr. De Oliveira Gamba, financially supported by the Brazilian coordination for the improvement of higher education personnel (CAPES; Process: 99999.010890/2014-09). Granted € 22.780. Brazilian coordination for the improvement of higher education personnel (CAPES; Process: 99999.010890/2014-09). Granted € 22.780: (2015, July 01 - 2016, July 01). Everts, V., Van Lenthe, G.H., Koolstra, J.H. & Lobbezoo, F. (2015). Biomechanical changes in articulation of the jaw joint due to aging. EU MOVE project. Granted 3 years full time: (2014, October 01 - 2017, October 01). Everts, V. (2015). Coordinator of FP7-PEOPLE-2013-Marie Curie ITN project EUROCLAST. Project with 7 academies and two private companies, 11 ESRs ( granted € 3.100.000): (2013, September 01 - 2017, September 01). Everts, V. (2015). NIRM grant on multinucleated giant cells. PhD student, granted € 280.000: (2011, September 01 - 2015, September 01). Feilzer, A.J., Klein Nulend, J., Kleverlaan, C.J. & Everts, V. (2015). Research priority grant. University of Amsterdam, € 1.650.000,-: (2012, January 01 - 2016, January 01). Feilzer, A.J. & Gibbs, S. (2015). Titanium implants and their emerging health problems: Development of a new accurate diagnostic test for titanium sensitivity in patients. Technology Foundation STW, € 560.000: (2014, January 01 - 2018, January 01). Forouzanfar, T. (2015). Klinische validatie van SPG-stimulatie in chronische clusterhoofdpijnpatiënten met het ATI-neurostimulatiesysteem. Innovatiefonds zorgverzekeraars, granted € 300.000,-: (2013, December 01 - 2016, December 01). Klein Nulend, J., ten Bruggenkate, C.M., Schulten, E.A.J.M. & Helder, M.N. (2015). ITI grant: Blood vessel formation and bone regeneration potential of the stromal vascular fraction containing adipose stem cells seeded on calcium phosphate scaffolds for bone augmentation in the human maxillary sinus floor elevation model. International Team for Implantology (ITI), granted € 36.158,-: (2015, August 01 - 2016, February 01). Klein Nulend, J., Helder, M.N. & Amoabediny, G. (2015). Skeletal tissue production using regenerative medicine and adipose stem cell technology for large bone defects. University of Tehran – Research Center for New Technologies in Life Sciences Engineering - sponsored project, granted € 200,000: (2013, January 01 - 2017, October 01).

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Van Lenthe, G.H. & Klein Nulend, J. (2015). European Union: MOVE-AGE Erasmus Mundus Joint Doctorate Program "Prevention of mobility loss with ageing". MOVE-AGE PhD project: Does the osteocyte lacuna affect bone adaptive response to aging? (PI: van Lenthe H, Co-PI: Klein-Nulend J) (1 fte PhD student, 3 yrs) granted € 180.000: (2013, January 01 - 2016, January 01). Gimenez, B., Hassan, B.A., Tahmaseb, A. & Wismeijer, D. (2015). Evaluation of a full digital workflow to fabricate CAD/CAM implant frameworks from digital impressions. In vivo and in vitro analysis. Scolarship, granted €52.000,-: (2013, January 01 - 2015, December 31). Gimenez, B., Hassan, B.A., Tahmaseb, A. & Wismeijer, D. (2015). Evaluation of a full digital workflow to fabricate CAD/CAM implant frameworks from digital impressions. In vivo and in vitro analysis (materials granted separately). granted €57.000,-: (2013, January 01 - 2015, December 31). Gorter, R.C. & Wismeijer, D. (2015). Digital dentistry in practice; On dentists' interaction with technological transformations. ITI research grant, to the amount of CHF 123.821: (2015, January 01 - 2015, December 31). Hespel, P. & Klein Nulend, J. (2015). European Union: MOVE-AGE Erasmus Mundus Joint Doctorate Program "Prevention of mobility loss with ageing": Understanding muscle and bone anabolic resistance in ageing: is ER involved?? MOVE-AGE project, granted € 180.000: (2012, January 01 - 2016, January 01). Jager, D.H.J. & Forouzanfar, T. (2015). Klinische inventarisatie van implantologie bij Sjögrenpatiënten in Nederland. NUTS OHRA, granted €150.000,-: (2013, December 01 - 2016, December 01). Jager, D.H.J. & Forouzanfar, T. (2015). Klinische inventarisatie van implantologie bij Sjögrenpatiënten in Nederland. BioHorizons inc., granted €118.000,-: (2013, December 01 - 2016, December 01). Klein Nulend, J., ten Bruggenkate, C.M., Schulten, E.A.J.M. & Helder, M.N. (2015). ITI grant: Blood vessel formation and bone regeneration potential of the stromal vascular fraction containing adipose stem cells seeded on calcium phosphate scaffolds for bone augmentation in the human maxillary sinus floor elevation model. International Team for Implantology (ITI), granted € 36.158,-: (2015, August 01 - 2016, February 01). Klein Nulend, J., Helder, M.N. & Amoabediny, G. (2015). Skeletal tissue production using regenerative medicine and adipose stem cell technology for large bone defects. University of Tehran – Research Center for New Technologies in Life Sciences Engineering - sponsored project, granted € 200,000: (2013, January 01 - 2017, October 01). Liu, Y. (2015). EMS grant. granted €48.700,-: (2013, January 01 - 2015, December 31). Liu, Y. & Wismeijer, D. (2015). ITI grant. ITI, granted €143.900,-: (2012, August 01 - 2015, August 01). Liu, Y. & Wismeijer, D. (2015). Peri-implantitis project. 46 Straumann implants, granted inkind: (2012, January 01 - 2015, December 31). Lobbezoo, F. (2015). Sunstar Suisse S.A.: Associations between sleep bruxism and peri-implant complications: a follow-up study. Project Grant, €150.000,-: (2014, January 01 - 2017, December 31). Muzalev, K.S., Yoshida, E., Wismeijer, D. & Lobbezoo, F. (2015). Associations between sleep bruxism and peri- implant complications: a follow-up study. NVGPT Onderzoekssubsidie, granted €5.000,-: (2012, January 01 - 2015, December 31). Scherder, E.J.A. & Lobbezoo, F. (2015). Diagnostiek en behandeling van pijn bij mensen met een dementia die thuis wonen of in het verpleeghuis zijn opgenomen. F. Lobbezoo responsible for the dental part of this project which equals approx. 1/3 of the total amount granted €126.667,-: NutsOHRA, RCOAK, SBOH, Henriëtte Hofje as sources for the funding of three PhD projects (NutsOHRA €150.000,-; RCAOK €160.000,-; Henriëtte Hofje €40.000,-; Alzheimer Nederland €30.000,-; total = €380.000,- (2012, January 01 - 2017, December 31). Scherder, E.J.A. & Lobbezoo, F. (2015). Pijn bij volwassenen met een verstandelijke beperking. F. Lobbezoo responsible for the dental part of this project which equals approx. 1/4 of the total amount granted €53.750,-: NutsOHRA, Fonds Verstandelijk Beperkten and Innovatiefonds as sources of funding for one PhD project (NutsOHRA, €150.000,-; Fonds Verstandelijk Gehandicapten €15.000,-; Innovatiefonds €50.000,-; Total €215.000,- (2010, January 01 - 2015, December 31). Schulten, E.A.J.M. & Forouzanfar, T. (2015). Straumann-instrumentarium. € 50.000,- in natura: (2015, January 01 - 2016, December 31). Tabassum, A., Tahmaseb, A., Liu, Y. & Wismeijer, D. (2015). A modified drilling protocol for implant site preparation and subsequent collection of bone autograft: a randomized controlled trial. CAMLOG Foundation, granted €73.210,-: (2012, September 01 - 2015, September 01). Tabassum, A., Wu, G., Liu, Y. & Wismeijer, D. (2015). ITI grant. ITI, granted €36.000,-: (2012, February 01 - 2015, February 01). Tahmaseb, A., Hassan, B.A. & Wismeijer, D. (2015). Immediate post extraction implant placement. granted inkind: (2013, January 01 - 2015, December 31).

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Tahmaseb, A., Hassan, B.A. & Wismeijer, D. (2015). One abutment versus multiple abutments. Nobel Biocare, Materials, granted €40.000,- inkind: (2014, January 01 - 2015, December 31). Van Eekeren, P.J.A. & Wismeijer, D. (2015). The comparison of osseointegration of Apliquiq implants with immediate vs delayed loading. A split mouth design. Thommen medical, granted €80.000,-: (2012, January 01 - 2015, December 31). Van Lenthe, G.H. & Klein Nulend, J. (2015). European Union: MOVE-AGE Erasmus Mundus Joint Doctorate Program "Prevention of mobility loss with ageing". MOVE-AGE PhD project: Does the osteocyte lacuna affect bone adaptive response to aging? (PI: van Lenthe H, Co-PI: Klein-Nulend J) (1 fte PhD student, 3 yrs) granted € 180.000: (2013, January 01 - 2016, January 01). Wismeijer, D. (2015). A pilot study looking at the treatment of edentulous patients with mini implants. granted €22.000,-: (2012, January 01 - 2015, December 31). Wismeijer, D. (2015). Comparing the immediate loading (within 48 hours) of two interconnected implants with an overdenture to the immediate loading of 4 mini dental implants and an overdenture in a randomized controlled clinical trial. granted €213.727,-: (2012, January 01 - 2015, December 31). Wismeijer, D., Bruers, J.J.M. & Reijers, H. (2015). Data mining naar de kosten effectiviteit van implantaatgedragen overkappingsprotheses in bestanden van de zorgverzekeraars. NWO project, Post Doc voor 1 jaar, granted €30.000,-: (2015, January 01 - 2015, December 31). Wismeijer, D. & Evans, C. (2015). Evaluating CAD CAM zirconium implant crowns. ITI grant (together with Chris Evans, Sydney, Australia), granted €30.000,-: (2015, January 01 - 2015, December 31). Wismeijer, D. (2015). This project aims to demonstrate a first-in-patient safety and clinical efficacy of BioCaP(- µconcentrations BMP2), a unique product for regenerative treatment of bone defects. ZonMw, granted 1033.509: (2014, January 01 - 2015, December 31). Wismeijer, D. & Tahmaseb, A. (2015). Evaluation of printed biomaterials in an animal model. Materials, granted €15.000,- inkind: (2015, January 01 - 2015, December 31). Wolff, J.E.H. & Forouzanfar, T. (2015). 3D-technology. DSM Grant 0,4 fte Phd student: Geleen, the Netherlands (2015, January 01 - 2016, December 31). Wu, G. (2015). ITI grant. ITI, granted €35.930,-: (2012, February 01 - 2015, February 01).

Indicators of Esteem

Editorship book Beysens, D.A. & Van Loon, J.J.W.A. (Eds.). (2015). Generation and applications of extra-terrestrial environments on earth (River Publishers Series in Standardisation, 6). Aalborg, Denmark: River Publishers. Chen, S., Buser, D. & Wismeijer, D. (2014). Alveolarkammaugmentationen bei Implantatpatienten (ITI Treatment Guide Series, 7). Berlin: Quintessenz Verlags-GmbH. Chen, S., Buser, D. & Wismeijer, D. (2015). İmplant hastalarında kemik artırım işlemler: aşamalı yaklaşım (ITI Treatment Guide Series, 7). Istanbul: Quintessence Yayincilik Tanıtım. Chen, S., Buser, D. & Wismeijer, D. (2015). Procedimentos de aumento de rebordo para a colocação de implantes (ITI Treatment Guide Series, 7). Sao Paulo: Quintessence Editora Ltda.. Chen, S., Buser, D. & Wismeijer, D. (2014). Procedure di aumento della cresta alveolare in pazienti con impianti dentali (ITI Treatment Guide Series, 7). Milan: Quintessenza Edizioni S.r.l. Chen, S., Buser, D. & Wismeijer, D. (2014). Procédures d'augmentation de la crête alvéolaire en implantologie (ITI Treatment Guide Series, 7). Paris: Quintessence International, Editeur. Chen, S., Buser, D. & Wismeijer, D. (2014). Ridge augmentation procedures in implant patients (in Japanese) (ITI Treatment Guide Series, 7). Tokyo: Quintessence Publishing Co. Ltd.. Chen, S., Buser, D. & Wismeijer, D. (2015). Ridge augmentation procedures in implant patients (in Russian) (ITI Treatment Guide Series, 7). Moscow: Quintessence Publishers. Chen, S., Buser, D. & Wismeijer, D. (2014). Ridge augmentation procedures in implant patients: a staged approach (ITI Treatment Guide Series, 7). Berlin: Quintessence Publishers. Chen, S., Buser, D. & Wismeijer, D. (2014). Técnicas de aumento del reborde alveolar en pacientes receptores de implantes (ITI Treatment Guide Series, 7). Barcelona: Editorial Quintessence, S.L. Feilzer, A.J. Praktijkboek Tandheelkunde. Member Editorial Board, since 2008.

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Laverman, J.V. (Ed.). (2014). Nazorg bij implantaten (AccreDidact. Tandartsen, 2014-3). Houten: AccreDidact. Lobbezoo, F. & De Baat, C. (Eds.). (2015). Occlusie en articulatie. wetenschappelijk bewijs en klinisch handelen. Houten: Prelum. Naeije, M., Lobbezoo, F. & Visscher, C.M. (Eds.). (2015). Orale kinesiologie: temporomandibulaire disfuncties, bruxisme, gebitsattritie en slaapapneu. Houten: Bohn Stafleu van Loghum. Wismeijer, D., Buser, D. & Chen, S. (2015). Biological and hardware complications in implant dentistry (ITI Treatment Guide Series, 8). Berlin: Quintessence Publ. Wismeijer, D., Buser, D. & Chen, S. (2015). Biological and hardware complications in implant dentistry (in Japanese) (ITI Treatment Guide Series, 8). Tokyo: Quintessence Publishing Co. Ltd. Wismeijer, D., Buser, D. & Chen, S. (2015). Biologische und materialbedingte Komplikationen in der zahnärztlichen Implantologie (ITI Treatment Guide Series, 8). Berlin: Quintessenz Verlags-GmbH. Wismeijer, D., Buser, D. & Chen, S. (2015). Complicaciones biológicas y complicaciones relacionadas con el material en implantología oral (ITI Treatment Guide Series, 8). Barcelona: Editorial Quintessence, S.L. Wismeijer, D., Buser, D. & Chen, S. (2015). Complicações biológicas e técnico-mecânicas na implantodontia (ITI Treatment Guide Series, 8). Sao Paulo: Quintessence Editora Ltda. Wismeijer, D., Buser, D. & Chen, S. (2015). Complicanze biologiche e implanto-protesiche in implantologia orale (ITI Treatment Guide Series, 8). Milan: Quintessenza Edizioni S.r.l. Wismeijer, D., Buser, D. & Chen, S. (2015). Complications biologiques et mécaniques en implantologie dentaire (ITI Treatment Guide Series, 8). Paris: Quintessence International, Editeur. Wismeijer, D., Buser, D. & Chen, S. (2015). İmplantolojide biyolojik ve donanımsal komplikasyonlar (ITI Treatment Guide Series, 8). Istanbul: Quintessence Yayincilik Tanıtım.

Memberships editorial board Aarab, G.: Journal of Dental Sleep Medicine. Bakker, A.D.: Odontology. De Lange, J.: ACTA Quality Practice. Everts, V.: International Journal of Dentistry. Everts, V.: International Journal of Oral Research. Everts, V.: The Open Bone Journal. Everts, V.: The Open Enzyme Inhibition Journal. Feilzer, A.J.: American Journal of Dentistry. Feilzer, A.J.: Odontology. Forouzanfar, T.: Journal of Surgical Case Reports. Forouzanfar, T.: Triple R. Goené, R.J.: European Journal of Oral Implantology. Goené, R.J.: Journal of Implant and Reconstructive Dentistry. Hassan, B.A.: BioMed Research International. Klein-Nulend, J.: Clinical Reviews in Bone and Mineral Metabolism. Klein-Nulend, J.: European Cells & Materials. Klein-Nulend, J.: Experimental and Clinical Endocrinology & Diabetes. Klein-Nulend, J.: Journal of Musculoskeletal Research. Klein-Nulend, J.: The Open Biology Journal. Klein-Nulend, J.: The Open Nitric Oxide Journal. Klein-Nulend, J.: The Open Tissue Engineering and Regenerative Medicine Journal. Koolstra, J.H.: Applied Bionics and Biomechanics. Koolstra, J.H.: Journal of Dental Biomechanics. Lobbezoo, F.: Journal of Craniomandibular Function. Lobbezoo, F.: Journal of Dental Sleep Medicine. Lobbezoo, F.: Journal of Oral Rehabilitation. Lobbezoo, F.: Quality Practice. Nascholingstijdschrift voor Tandartsen. Poorterman, J.H.G.: Nederlands Tijdschrift voor Tandheelkunde. Sanderink, G.C.H.: Dentomaxillofacial Radiology. Sanderink, G.C.H.: Oral Radiology. Tahmaseb, A.: Forum Implantologicum. Van Calcar, N.P.: DeTandartspraktijk.

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Van der Stelt, P.F.: Clinical Oral Implants Research. Van der Stelt, P.F.: Dentomaxillofacial Radiology. Van der Stelt, P.F.: Journal of Dentistry Shiraz University of Medical Sciences. Van der Stelt, P.F.: Odontology. Van Loon, J.J.W.A.: BioMed Research International. Visscher, C.M.: Journal of Craniomandibular Function. Wu, G.: Edorium TM Journal of Dentistry.

Scientific awards/honours Alharbi, N.W. (2015). First prize for the best poster: The influence of build orientation on accuracy of 3D- printed restorations. 16th Biennial Meeting International College of Prosthodontists (ICP): Seoul, South Korea (2015, September 17 - 2015, September 20). Bonn, C.E.H.M., van Selms, M.K.A., te Poel, F., Visscher, C.M., Lobbezoo, F. & Naeije, M. (2015). NTVT price Debute 2015 (young researcher publication price €1500,-): Onderscheid tussen temporomandibulaire pijn en andere vormen van orofaciale pijn op basis van een vragenlijst. Nederlands Tijdschrift voor Tandheelkunde 2013, 120, 28-33. NTVT-Auteursdag: Spoorwegmuseum, Utrecht, the Netherlands (2015, June 05). Chen, H. (2015). Finalist IADMFR Research Award. International Association of DentoMaxilloFacial Radiology: Santiago de Chile (2015, August 27). Gibbs, S. (2015). Lef in het Lab-prijs 2015 voor het huid-op-een-chip model. Dierenbeschermingscentrum; Wereldproefdierendag: Amersfoort, the Netherlands (2015, April 23 - 2015, April 24). Koutris, M. (2015). IADR Neuroscience Group Young Investigator award by Willey-Blackwell, Journal of Oral Rehabilitation 2015. First prize €1000 for the best poster presentation: Experimental DOMS does not influence the masticatory system's psychophysical properties, by R. Bucci, F. Lobbezoo, C. Arfanou, A. Michelotti and M. Koutris. IADR General Session: Boston, Mass., USA (2015, March 11 - 2015, March 14). Pathak, J.L. (2015). Dutch Society for Calcium and Bone Travel Grant 2015. 4th Joint Meeting ECTS & IBMS: Rotterdam, The Netherlands (2015, April 25 - 2015, April 28). Pathak, J.L. (2015). ECTS & IBMS New Investigator Award 2015. 4th Joint Meeting European Calcified Tissue Society (ECTS) & International Bone and Mineral Society (IBMS): Rotterdam, The Netherlands (2015, April 25 - 2015, April 28). Pathak, J.L. (2015). MOVE Award 2015 for the best publication: Inflammatory factors in the circulation of patients with rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts. 6th Annual MOVE Research Meeting 2015: Amsterdam, The Netherlands (2015, February 04). Sanderink, G.C.H. (2015). Honorary membership. International Association of DentoMaxilloFacial Radiology (IADMFR). Sprangers, S.L. (2015). NVCB-presentatieprijs voor jonge onderzoekers € 500. 25th Annual meeting Nederlandse Vereniging voor Calcium- en Botstofwisseling (NVCB): Zeist, the Netherlands (2015, November 18 - 2015, November 19). Wang, D. (2015). Heraeus Kulzer Travel Award for the best posterpresentation: Osteoinducer improves osteogenic efficacy of calcium phosphate bone substitute. IADR General Session: Boston, Mass., USA (2015, March 12).

Organization of (inter)national scientific congresses and symposia Bakker, A.D. (2015). Organizing committee. Postdoc Course European Calcified Tissue Society: Rotterdam, the Netherlands (2015, April 24 - 2015, April 25). Becking, A.G. (2015). Organizer. Biannual Symposium Surgical Orthodontics (BSSO): Haarlem, the Netherlands (2015, November 26 - 2015, November 27). Klein Nulend, J., Bakker, A.D., Bravenboer, N. & Pathak, J.L. (2015). Organizing committee. Symposium Bone cell communication and bone loss in rheumatoid arthritis: ACTA, Amsterdam, the Netherlands (2015, June 19). Koutris, M. (2015). Organizer. 2nd symposium of the Greek Association of Contemporary Dentistry: Intraoral devices used for the protection from the effects of bruxism: design, indications, and clinical application: Athens, Greece (2015, May 09).

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Lobbezoo, F. (2015). Organizer. Nationaal Aangezichtspijncongres: Amsterdam, the Netherlands (2015, March 27). Lobbezoo, F., Koutris, M. & Wetselaar, P. (2015). Organizing committee. Closed Annual Meeting European Academy of Craniomandibular Disorders (EACD): Amsterdam, the Netherlands (2015, September 24 - 2015, September 25). Lobbezoo, F., & Wetselaar, P. (2015). Organizing committee. Jaarcongres Nederlandse Vereniging voor Gnathologie en Prothetische Tandheelkunde (NVGPT) Kauwen op bruxisme - de nieuwste inzichten en praktische implicaties: Ermelo, the Netherlands (2015, December 10 - 2015, December 11).

Invited speakers at (inter)national congresses or symposia Aarab, G. (2015, September 25). Obstructive sleep apnea: an overview. Amsterdam, the Netherlands, Closed meeting of the European Academy of Craniomandibular Dysfunction (EACD). Aarab, G. (2015, December 05). The effects of titration on OSA. Germany, Annual congress of the German society of Dental Sleep Medicine (DGZS). Aarab, G. (2015, June 06). Treacher Collins syndrome patient with OSA. Seattle, USA, Annual congress of the American Academy of Dental Sleep Medicine (AADSM). Becking, A.G. (2015, October 27). 1. The value of endoscopic assisted orbital reconstruction. 2. Contemporary diagnosis and treatment of condylar hyperplasia. Melbourne, Australia, 22nd International Conference on Oral & Maxillofacial Surgery (ICOMS). Becking, A.G. (2015, October 28). One-stage resection and reconstruction of skull defects in cranioplasty. Melbourne, Australia, 22nd International Conference on Oral & Maxillofacial Surgery (ICOMS) 26-31 October. Berkhout, W.E.R. (2015, September 16). The limitations of CBCT. Barcelona, Spain, 17th Congress of the European Society of Endodontology 16-19 September. Dubois, L. (2015, October 27). 1. Can navigation assisted surgery raise the predictability of orbital reconstruction. 2. Implant oriented navigation, the new panacea for orbital reconstruction. Melbourne, Australia, 22nd International Conference on Oral & Maxillofacial Surgery (ICOMS). Everts, V. (2015, September 22). New developments in bone biology. Bangkok, Thailand, FDI-meeting. Everts, V. (2015, October 02). 1. New developments in bone biology. 2. How to write a good scientific paper. Bangkok, Thailand, Prince of Songkla University. Forouzanfar, T. (2015, September 28). 3D technologie. Makassar, Indonesia, Indonesian Dental Association Meeting. Forouzanfar, T. (2015, November 09). Stem cell and 3D technology. South Korea, Korean Meeting. Forouzanfar, T. (2015, September 29). Stem cell treatment and maxillofacial surgery. Makassar, Indonesia, Indonesian Dental Association Meeting. Gibbs, S. (2015, November 30). Invited participant. Amsterdam, the Netherlands, Workshop ZonMW TO. Gibbs, S. (2015, June 01). Progress towards immune competent skin on a chip. Berlin, Germany, Stakeholders meeting Berlin, Organ on a chip. Gibbs, S. (2015, November 30). Regenerative Medicine. Utrecht, the Netherlands, MSc workshop. Gibbs, S. (2015, November 07). Understanding the mechanistic differences between sensitization and irritation with the aid of tissue engineered skin models. Natal, Brazil, Congress of Toxicology for Developing Countries. Hassan, B.A. (2015, November 20). Digital facial scanning applications in prosthodontics. Madrid, Spain, Prosthodontics study group, Complutence University. Klein Nulend, J. (2015, June 22). Bone. Udine, Italy, Centre International des Sciences Méchaniques (CISM), Advanced School, Bone Cell and Tissue Mechanics. Klein Nulend, J. (2015, September 13). Bone cells: Osteocytes. Siena, Italy, European Calcified Tissue Society (ECTS) PhD Training Course. Klein Nulend, J. (2015, September 21). Bone tissue engineering: New developments. Tehran, Iran, Symposium Tissue Engineering organized by Research Center for New Technologies in Life Science Engineering, University of Tehran. Kleverlaan, C.J. (2015, October 15). Bulk Fill materials, bottom-up? IADR, Antalya, Turkey. Koutris, M. (2015, May 09). Bruxism: diagnosis and management. Athens, Greece, 2nd symposium Greek Association of Contemporary Dentistry. Koutris, M. (2015, June 05). Pijn, neurofysiologie, hoofdpijn, neuropathie, etc. Amsterdam, the Netherlands, Endo Leergang 2014-2015, ACTA.

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Koutris, M. (2015, October 10). Clinical approach of patients with temporomandibular disorders. Rhodes, Greece, 35th Panhellenic Dental Congress. Koutris, M. (2015, February 02). Is bruxism a contra-indication for implants? Ioannina, Greece, ITI Study Club of Western Greece. Koutris, M. (2015, September 26). Sleep and orofacial pain. Amsterdam, the Netherlands, Closed Meeting of the EACD. Koutris, M. (2015, November 30). Temporomandibular disorders. Athens, Greece, Hellenic Stomatologic Association, Webinar. Koutris, M. (2015, October 09). Treatment of patients with temporomandibular disorders. Rhodes, Greece, 35th Panhellenic Dental Congress. Liu, Y. (2015, July 03). Biobone: research, development and clinical applications. Interdisciplinary approach in treatment of dentistry & digital implantology. Shandong, China, Yanti. Lobbezoo, F. (2015, March 13). Assessment of Orofacial Pain in Dementia. Boston, MA, IADR Symposium Oral health and cognitive impairment in older adults. Lobbezoo, F. (2015, November 16). Associations between sleep bruxism and peri-implant complications: update of an ongoing follow-up study. Frankfurt, Germany, Sunstar Academic Advisory Board Meeting. Lobbezoo, F. (2015, January 30). Bruxism and TMD. Munich, Germany, IAAID International Congress on Bruxism 2015. Lobbezoo, F. (2015, June 12). Chewing over bruxism. Bergen, Norway, Scandinavian Society for Prosthetic Dentistry. Lobbezoo, F. (2015, April 17). Defining and grading of sleep bruxism. Amsterdam, the Netherlands, Academic Advisory Board Meeting Grindcare/Sunstar. Lobbezoo, F. (2015, September 25). Dental Sleep Medicine – Overview. Amsterdam, the Netherlands, EACD. Lobbezoo, F. (2015, March 10). Dissemination of diagnostic criteria for temporomandibular disorders. Welcome & Introduction lecture. Boston, MA, IADR Satellite Symposium. Lobbezoo, F. (2015, April 25). Orofacial pain in dementia. Bergen, Norway, 7th International Congress on Pain in Dementia. Lobbezoo, F. (2015, March 27). Tandarts: laatste redmiddel? Amsterdam, the Netherlands, Nationaal Aangezichtspijncongres 2015. Lobbezoo, F. (2015, March 04). The management of obstructive sleep apnea in dentistry. New York, USA, Seminar, New York University College of Dentistry. Lobbezoo, F. (2015, June 11). The management of OSA in dentistry. Bergen, Norway, Scandinavian Society for Prosthetic Dentistry. Tahmaseb, A. (2015, April 01). Computer technology applications in surgical implant dentistry. CAI Academy congress Imagina Dental. Tahmaseb, A. (2015, November 26). Innovations chirurgicales: chirurgie guidée/régénération osseuse sur mesure. Palais des Congres, Paris, France, R-Évolution Numérique, Association Dentaire Francais (ADF). Tahmaseb, A. (2015, November 26). Keynote speaker. Joint German and Austrian Osseointegration societies meeting. Tuinzing, D.B. (2015, February 16). Clinical demonstrations. Paramaribo, Surinam, University hospital. Tuinzing, D.B. (2015, February 12). Stability of surgical orthodontics. Leiden, the Netherlands, European Begg Society, LUMC. Tuinzing, D.B. (2015, February 10). Surgical Orthodontics course. Wales, UK, Wooley Course. Tuinzing, D.B. (2015, January 24). Surgical Orthodontics fur Anfanger/Geforderte. Spitzingsee, Germany, Bayerishe Zahnartz Verein. Van der Stelt, P.F. (2015, February 04). 1. Responsibility of the CBCT-user. 2. Justification as the most important factor for dose reduction. Tehran, Iran, 7th Oral and Maxillofacial Radiology Congress 4-6 February. Van der Stelt, P.F. (2015, April 17). Referral criteria for CBCT. What are the options and responsibilities of the clinician? Izmir, Turkey, Oral Diagnosis and Maxillofacial Radiology Society VI. National Scientific Symposium and I. International Congress 17-19 April. Van Loon, J.J.W.A. (2015, September 29). Life into Gravity Related Life Sciences. Corfu, Greece, ELGRA 22nd biannual Symposium and General Assembly. Van Loon, J.J.W.A. (2015, February 16). Sensing changes of the gravitational load. From cells to organisms and beyond. King’s College, London, United Kingdom, Master course: Human and Aerospace Physiological Sciences, Division of Applied Biomedical Research Department of Physiology.

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Van Loon, J.J.W.A. (2015, December 14). Moon as a stepping stone for Mars: Centrifuge on the moon! Noordwijk, the Netherlands, At: Moon 2020 - 2030 : A new era of coordinated human and robotic exploration / exploration technology showcase, ESTEC. Visscher, C.M. (2015, June 22). Temporomandibular disorders. Berlin, Germany, Teaching course: Facial pain; diagnosis and management. European Academy of Neurology. Visscher, C.M. (2015, September 25). Diagnostics of temporomandibular disorders. Amsterdam, the Netherlands, Closed meeting EACD. Wetselaar, P. (2015, September 26). Sleep disorders and their associations with tooth wear. Amsterdam, the Netherlands, Closed Meeting EACD. Wetselaar, P. (2015, November 04). The tooth wear evaluation system. Malmö, Sweden, Malmö University, section of Orofacial Pain & Jaw Function. Wismeijer, D. (2015, September 25). CAD/CAM in removable prosthodontics. Stockholm, Sweden, EAO Straumann Satellite Industry symposium. Wismeijer, D. (2015, May 07). Digital implant dentistry. Where is this all the taking us. Manchester, UK, British Dental conference 2015. Wismeijer, D. (2015, October 30). Layering, milling or printing dental restorations? Basel, Switzerland, Swiss Society of Restorative Dentistry. Wismeijer, D. (2015, May 09). Milling so 2014. Jermahia Hotel Dubai, 10th CAD CAM and Dentistry international conference. Wismeijer, D. (2015, November 13). Milling so 2014. Zurich, Switzerland, International Academy of Digital Dental Dentistry (IADDM), 1st Annual meeting. Future in Dental Medicine: The team approach. Wismeijer, D. (2015, December 04). Milling so 2014. Singapore, Indonesia, 10th CAD/CAM Digital Dentistry conference. Wismeijer, D. (2015, September 11). Technical decision making. 1. Abutment and material selection. 2. How to control the virtual treatment planning. Helsinki, Finland, ITI congress Clinical controversies. Wismeijer, D. (2015, May 14). The digital dental school. London, UK, CONSEURO together with Kings College London . Queen Elisabeth II conference center. Wismeijer, D. (2015, September 24). Treating the edentulous patient. Stockholm, Sweden, EAO Straumann Satellite Industry symposium.

Other (inter)national scientific functions Aarab, G.: Member research committee - American Academy of Dental Sleep Medicine (AADSM), since 2012. Bakker, A.D.: Reviewer project proposal - Croatian Science Foundation. Bakker, A.D.: Board member - Dutch Society for Calcium and Bone Metabolism. Bakker, A.D.: Chair training committee - European Calcified Tissue Society. Bakker, A.D.: Chair new investigators committee - European Calcified Tissue Society. Bakker, A.D.: Co-chair new investigator committee - European Calcified Tissue Society. Bakker, A.D.: Board member - European Calcified Tissue Society. Bakker, A.D.: Reviewer - FWO grant applications, Belgium. Bakker, A.D.: Member scientific program committee - Herbert Fleisch workshop II. Berkhout, W.E.R.: Member - Central Council European Academy of Dento-Maxillo-Facial Radiology (EADMFR). Berkhout, W.E.R.: Chairman Research and Scientific Committee - European Academy of Dento-Maxillo-Facial Radiology (EADMFR). Everts, V.: Visiting professor - Chulalongkorn University, Bangkok, Everts, V.: Member and principal investigator - NIRM. Gibbs, S.: Member - European Research Group for Experimental Contact Dermatitis (ERGECD). Gibbs, S.: Reviewer - Gingerelll Alfred Research Austria. Gibbs, S.: Member and principal investigator - NIRM. Gibbs, S.: Jury member - Project NC3Rs, London, UK. Gibbs, S.: Jury member - Project STW. Gibbs, S.: Reviewer - ZonMW.

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Klein-Nulend, J.: Board member - American society for Bone and Mineral Research (ASBMR) Women in Bone and Mineral Research Committee, USA, 2015- 2018. Klein-Nulend, J.: Member scientific board - Department of Regenerative Medicine, Research Centre for New Technologies in Life Science Engineering, University of Tehran, Iran. Klein-Nulend, J.: Member research assessment committee - Group Biomedical Sciences (Dept. Oral Health Sciences and Dept. Development and Regeneration), KU Leuven, Belgium. Klein-Nulend, J.: Outer board member - Irish Research Council Postdoctoral International Assessment 2015 (Fellowships in Science, Engineering and Technology), Royal Irish Academy. Klein-Nulend, J.: Founding member - Micro-mechanical Tissue Repair Society. Klein-Nulend, J.: VICI-Assessment committee member - Organisation for Scientific Research (NWO). Domain: Life Sciences, Utrecht, the Netherlands. Klein-Nulend, J.: External professor - San Carlos University, Dept. Physics, Cebu City, Philippines. Koutris, M.: Chair research committee - European Academy of Craniomandibular Disorders (EACD), since 2011. Koutris, M.: Board member - Greek Society of Orofacial Pain, since 2014. Koutris, M.: Member - RDC-TMD Consortium, Calibration Committee, since 2014. Koutris, M.: Member - RDC-TMD Consortium, Governance Committee, since 2015. Lobbezoo, F.: President - International RDC/TMD Consortium Network, IADR (2015- 2018). Lobbezoo, F.: Senior member - Society of Oral Physiology (Store Kro Club), since 2015. Lobbezoo, F.: NYU Visiting Guest Faculty Recipient 2014-2015 - College of Dentistry, New York University, New York, NY, USA. Sanderink, G.C.H.: Chairman - Trust Fund International Association of DentoMaxilloFacial Radiology. Schulten, E.A.J.M.: Fellow - International Team for Implantology (ITI), Basel, Switzerland. Tahmaseb, A.: Member - EAO consensus meeting Pfafficon Switzerland 14-02-2015. Tahmaseb, A.: Member - ITI Education deligate Dutch section 14-02-2015. Visscher, C.M.: Board member - Physical Therapy Board of Craniofacial and Cervical Therapeutics (PTBCCT), USA, since 2003. Van Loon, J.J.W.A.: Reviewer - European Commission: REA; EC-SPACE-CALL COMPET-4- 2015, Brussel, Belgium, 26 June-2 July 2015. Van Loon, J.J.W.A.: Vote-selected member - Governing board member, American Society for Gravitational and Space Biology (ASGSB), period 2015-2018. Van Loon, J.J.W.A.: External examiner - Limerick Institute of Technology. MSc. thesis from Adam Shinner: Microgravity induced phytohormones. Wismeijer, D.: Member - EAO consensus meeting Pfafficon Switzerland 14-02-2015. Zandieh Doulabi, B.: Visiting professor - Research Center for New Technologies in Life Sciences Engineering, University of Tehran, Iran. Zandieh Doulabi, B.: Head Department Regenerative Medicine - Research Centre for New Technologies in Life Science Engineering, University of Tehran, Iran.

Supervisor of an external PhD student Lobbezoo, F. (2015). Co-supervisor of external PhD student N.C. de Knegt with thesis: The down side of pain - Pain assessment and experience in adults with Down Syndrome and the relationship with cognition. Supervisors: prof.dr. E.J.A. Scherder & prof.dr. H.M. Evenhuis; co-supervisors: prof.dr. F. Lobbezoo & prof.dr. C. Schuengel - VU University Amsterdam, 22 September 2015. Wolff, J. Supervisor of external PhD student Juha Koivisto with thesis: The application and performance of MOSFET radiation dosimeters - University of Tampere, University of Helsinki, Finland, 16 October 2015.

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Collaborations - Amsterdam University of Applied Sciences, prof. dr. R. Engelbert, Amsterdam, the Netherlands. - Centre of Oral Rehabilitation, Norrköping, Sweden, Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmö University, Sweden, Scandinavian Center for Orofacial Neurosciences, dr. P Larsson. - Chulalongkorn University, Bangkok, Thailand, P. Pavasant. - Cipto Mangukusumo Hospital, Jakarta, Republic of Indonesia. - Department of Oral and Maxiillofacail Surgery, University of Torino, Italy. - Department of Orthopedics, VUmc. - Department of Radiology, University of Helsinky, Finland. - Ege University, Faculty of Medicine, Center for Brain Research & Department of Physiology, prof.dr. K. Türker, Bornova, Izmir, Turkey. - Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, dept. of Surgery and Orthopaedics, Da Silveira, L.D., guest researcher Sept. 2014-Sept. 2015. - Massachusetts General Hospital/Harvard University, Dept. of OMFS. - National Institutes of Health Washington DC. - Radboudumc, IQ-healthcare, prof.dr. R. Nijhuis, Nijmegen, the Netherlands. - Slotervaart General Hospital, Department of Clinical Neurophysiology and Brain Mapping Laboratory, dr. H.L. Hamburger, Amsterdam, the Netherlands. - State University of Campinas, Piracicaba Dental School, Piracicaba, Brazil. Prof. M. Lima de Oliveira and Prof. S.M. Almeida Boscolo. - TNO Life Style - Behavioral and Societal Sciences, dr. E. Vermaire and A. Schuller, Leiden, the Netherlands. - Universitat International Catalunya, Barcelona, Spain. - Universiteit Zurich, MKG. - University at Buffalo, Department of Oral Diagnostic Sciences, dr. R. Ohrbach, Buffalo (NY), USA. - University Estadual Paulista (UNESP), Department of Dental Materials and Prosthodontics, prof.dr. Daniela Aparecida de Godoi Gonçalves and prof.dr. Cinara M. Camparis, Araraquara School of Dentistry, Araraquara, Brazil. - University Medical Center (UMC) Utrecht and Radboudumc, IQ-healthcare, dr. CM Speksnijder, Nijmegen, the Netherlands. - University of Aarhus, Department of Orofacial Pain and Jaw Function, prof. dr. Peter Svensson, Aarhus, Denmark. - University of Helsinki, Department of Stomatognathic Physiology & Prosthetic Dentistry, dr. J. Ahlberg, Helsinki, Finland. - University of Minnesota, Department of Diagnostic and Biological Sciences and Division of Epidemiology and Community Health, Minneapolis, Minnesota, USA, dr. Mike T John. - University of Montreal. Faculty of Dentistry, prof.dr. Gilles Lavigne, Montreal, PQ, Canada. - University of Padova, TMD Clinic, prof. dr. D. Manfredini, Padova, Italy. - University of Tel Aviv, Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, prof. dr. Efraim Winocur, Tel Aviv, Israel. - University of Tokushima, E. Tanaka. - University of Umea, Faculty of Medicine, department of Clinical Oral Physiology, prof. dr. A. Wännman, Umea, Sweden. - University of Washington Medical Center, Seattle. Dept. of OMSF. - Vrije Universiteit, Department of Clinical Neuropsychology, prof.dr. E.J.A. Scherder, Amsterdam, the Netherlands. - Vrije Universiteit, Nederlands Tweelingen Register (NTR), prof.dr. D.I. Boomsma, Amsterdam, the Netherlands.

Current PhD projects Abdel Aziz, MFA. Diagnostic and therapeutic methods for small caries lesions in micro-invasive dentistry. Supervisors: prof.dr. A.J. Feilzer & prof.dr. I. Krejci, start: 2014. Alharbi NW. Printing dental restorations. Supervisor: prof.dr. D. Wismeijer; co-supervisors: dr. A. Tahmaseb & dr. R. Osman, start: 2013. Anssari Moin D. Printing / milling root analogue implants. Supervisor: prof.dr. D. Wismeijer; co-supervisors: dr. A. Tahmaseb & dr. B.A. Hassan, start: 2012.

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Asikainen PJ. Implantology. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten, start 2011. Baas EM. BSSO versus distraction osteogenesis of the mandible. Supervisors: prof.dr. J. de Lange & profd.r A.G. Becking; co-supervisor: dr. D.M.J. Milstein, promotion: 1-7-2015. Baggen JHM. Neuropathic pain and TMD pain. Supervisor: prof.dr. F. Lobbezoo; co-supervisors: dr. M. Koutris & dr. C.M. Visscher, start: 2014. Bastidas Coral AP. Osteogenic differentiation of mesenchymal stem cells by bioactive molecules and mechanical loading in a 3D environment: Implications for craniomaxillofacial bone defects. Supervisors: prof.dr. J. Klein-Nulend & prof.dr. T. Forouzanfar; co-supervisors: dr. C.J. Kleverlaan & dr. A.D. Bakker, start: December 2013. Beerens, MW. Treatment of incipient white spot lesions. Supervisor: prof.dr. J.M. ten Cate; co-supervisor: dr.ir. M.H. van der Veen, start: 2009. Betti BF. Effects of bruxism-like mechanical loading of TMJ cartilage of pigs. Supervisors: prof.dr. F. Lobbezoo & prof.dr. V. Everts; co-supervisors: dr. A.D. Bakker & dr. G.E.J. Langenbach, start: 2014. Boffano P. Mandibular trauma: epidemiology, management and imaging. Supervisors: prof.dr. T Forouzanfar & prof.dr. E.A.J.M. Schulten; start 2011. Boink MA. Novel saliva-derived peptides for state-of-the-art clinical wound-healing applications. Supervisors: prof.dr. S. Gibbs & prof.dr. E.C.I. Veerman, co-supervisor: dr. J.G.M. Bolscher, start: November 2010. Bouwman WF. Sinus floor elevation with bone and bone substitutes. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten; co-supervisor: dr. N. Bravenboer, start 2011. Buskermolen JK. Tissue engineering gingiva for in vitro assays and safety assessment of dental materials. Supervisors: prof.dr. S. Gibbs & prof.dr. A.J. Feilzer; co-supervisors: dr. C.J. Kleverlaan & dr. A.D. Bakker, start: June 2013. Cao Y. Different osteoclasts and their response to cytokines. Supervisor: prof.dr. V. Everts, co-supervisor: dr.ir. T.J. de Vries, start 2014. Chalil S. Understanding muscle and bone anabolic resistance in ageing: is ER stress involved? Supervisors: prof.dr. P. Hespel, prof.dr. L. Deldicque & prof.dr. J. Klein-Nulend; co-supervisors: dr. A.D. Bakker & dr. R. Manders, start: 2012. Chen H. The use of cone beam computed tomography images in the treatment planning of obstructive sleep apnea. Supervisors: prof.dr. P.F. van der Stelt, prof.dr. F. Lobbezoo & prof.dr. J. de Lange; co-supervisor: dr. G. Aarab, start: November 2013. Daher, R. Optimizing the restoration of endodontically treated posterior teeth. Supervisors: prof.dr. A.J. Feilzer & prof.dr. I. Krejci, start: 2014. De Graaf, NPJ. Development of a new accurate diagnostic test for titanium sensitivity in patients. Supervisors: prof.dr. A.J. Feilzer & prof.dr. T. Rustemeyer; co-supervisors: prof.dr. S. Gibbs & dr. C.J. Kleverlaan, start: 2014. De Jong T. Tissue engineering of the periodontal ligament. Supervisor: prof.dr.ir. T.H. Smit; co-supervisor: dr. A.D. Bakker, start: November 2012. De Ruiter MHT. Surgical treatment options for OSAS. Supervisor: prof.dr. J. de Lange; co-supervisor: prof. dr. N. de Vries, start: October 2012. De Vries MW. The association between artritis and oral tissues. Supervisors: prof.dr. F. Lobbezoo & prof.dr. D. van Schaardenburg; co-supervisors: prof.dr. B.G. Loos & prof.dr. W. Crielaard; daily supervision: dr. C.M. Visscher, start 2015. Delwel S. Oral health & orofacial pain in dementia. Supervisors: prof.dr. F. Lobbezoo & prof.dr. C.M.P.H. Hertogh; co-supervisors: prof.dr. E.J.A. Scherder & dr. R.S.G.M. Perez, start: 2012. Derksen WDC. The full digital workflow. Supervisor: prof.dr. D. Wismeijer; co-supervisors: dr. A. Tahmaseb & Tio, start: 2012. Dubois L. Unilateral condylar hyperplasia. Supervisors: prof.dr. A.G. Becking & prof.dr. J. de Lange, co- supervisor: dr. P.G. Raijmakers, start: September 2011. Evans C. Zirconia crowns and bridges on implants. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2014. Fazaeli S. Structure and function of the temporomandibular disk: new challenges for tissue engineering. Supervisors: prof.dr. V. Everts & prof.dr.ir. T.H. Smit; co-supervisor: dr.ir. J.H. Koolstra, start: 2011. Gobel JC. Combined therapy options for OSA patients. Supervisors: prof.dr. J. de Lange & prof.dr. N. de Vries, start: 2015. Gregor, L. Low shrinkage dental composites. Supervisors: prof.dr A.J. Feilzer & prof.dr. I. Krejci, start: September 2008.

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Heidsieck DSP. Management of obstructive sleep apnea in edentulous patients. Supervisors: prof.dr. J. de Lange & prof.dr. N. de Vries, start: 2014. Hemmatian H. Does the osteocyte lacuna affect bone adaptive response to aging? Supervisors: prof.dr.ir. G.H. van Lenthe & prof.dr. J. Klein-Nulend; co-supervisor: dr. A.D. Bakker, start: November 2015. Hoogeveen RC. Dose reduction in orthodontic radiography. Supervisor: prof.dr. P.F. van der Stelt; co- supervisors: dr. G.C.H. Sanderink & dr. W.E.R. Berkhout, start: 2012. Houwing M. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten, start 2014. Jalali R. The regulation of pH by ameloblasts during enamel mineralization. Supervisor: prof.dr. V. Everts, co- supervisors: dr. A.L.J.J. Bronckers & dr. B. Zandieh-Doulabi, start: September 2012. Jansen DC. Osteoclast heterogeneity. Supervisor: prof.dr. V. Everts, co-supervisor: dr.ir. T.J. de Vries, start: 2010. Karssemakers LHE. PET en SPEC scans in orofacial surgery. Supervisors: prof.dr. D.B. Tuinzing & prof.dr. A.G. Becking, start: 2009. Kommers SC. Etiology and treatment of malocclusion after trauma. Supervisor: prof.dr. T. Forouzanfar, start: 2011. Kuik K. Surgical results of MMO procedures in OSA patients. Supervisor: prof.dr. J. de Lange, start: 2015. Lin X. Biomaterials as a carrier for BMP-2: an in vivo study. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. Y. Liu, start: 2012. Liu Y. Signaling pathways accounting for the significantly higher efficiency of heterodimeric BMP. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. G. Wu, start: 2015. Mirahmadi F. Biomechanical changes in articulation of the jaw joint due to aging. Supervisors: prof.dr. V. Everts & prof.dr. H. van Lenthe; co-supervisors: dr.ir. J.H. Koolstra & prof.dr. F. Lobbezoo. start 2014. Mokhtari-Jafari F. Simulation of bone cell growth in 3D scaffolds for optimization of bone formation in a bioreactor. Supervisors: prof.dr.ir. G. Amoabediny (University of Tehran, Iran) & prof.dr. J. Klein-Nulend; co-supervisors: dr. B. Zandieh Doulabi & dr. M.N. Helder (Orthopaedics, Vumc), start: December 2014. Muzalev KS. The relation between the type of bruxism & temporomandibular disorders. Supervisor: prof.dr. F. Lobbezoo; co-supervisor: dr. C.M. Vissche, start 2011. Nikolopoulou M. Effects of comorbidities on OSAS and its treatment outcome. Supervisors: prof.dr. F. Lobbezoo & prof.dr. J. de Lange; co-supervisors: dr. G. Aarab & dr. J. Ahlberg, start: 2014. Nolte JW. Distraction osteogenesis in orofacial surgery. Supervisors: prof.dr. A.G. Becking & prof.dr. D.B. Tuinzing, start: 2011. Overman JR. Bone augmentation with autologous mesenchymal stem cells from adipose tissue, BMP-2, and calcium phosphate carrier materials in the sinusfloor elevation model. Supervisors: prof.dr J. Klein-Nulend, & prof.dr. E.A.J.M. Schulten; co-supervisors: prof.dr C.M. ten Bruggenkate & dr. M.N. Helder, start: November 2008. Pathak JL. The etiology of generalized osteoporosis in rheumatoid arthritis. Supervisors: prof.dr J. Klein-Nulend & prof.dr. F.P. Luyten; co-supervisors: dr. A.D. Bakker, dr. N. Bravenboer & prof.dr. P. Vanderschueren, start: October 2011. Renders G.A.P. Consequences of mechanical interaction between cartilage and bone for development of osteoarthrosis. Supervisor: prof.dr. V. Everts; co-supervisor: dr. G.E.J. Langenbach; start 2007. Restrepo Serna CMC. Bruxism in a stratified general population sample of children in Colombia. Supervisors: prof.dr. F. Lobbezoo & prof.dr. D. Manfredini, start: 2014. Rozeboom AVJ. Treatment of fractures of the condylar head. A randomized clinical trial. Supervisors: prof.dr. J. de Lange & prof. dr. R.R.M. Bos, start: September 2011. Ruslin M. Etiology of relapse after orthognatic surgery. Supervisors: prof.dr. T. Forouzanfar & prof.dr. D.B. Tuinzing, start: 2011. Saatchi A. Development and implementation of medical treatments for bone defects and bone disease. Supervisors: prof.dr.ir. G. Amoabediny (University of Tehran, Iran) & prof.dr. J. Klein-Nulend; co- supervisors: dr. M.N. Helder (VUmc) & dr. B. Zandieh Doulabi, start: 2013. Salehi-Nik S. Effects of surface modification and mechanical loading on the response of endothelial cells loaded in biohybrid lung bioreactors. Supervisors: prof.dr.ir. G. Amoabediny (University Tehran, Iran) & prof.dr. J. Klein-Nulend; co-supervisors: dr. B. Zandieh Doulabi & prof.dr. M.H. Shokrgozar, start: 2012. Scholtanus, JD. Bonding to carious dentin. Supervisors: prof.dr. A.J. Feilzer & prof.dr. M. Özcan; co-supervisor: dr. C.J. Kleverlaan, start: April 2009. Shang L. Different interactions between commensal and pathogen with host cells. Supervisors: prof.dr. C. van Loveren & prof.dr. S. Gibbs; co-supervisors: prof.dr. W Crielaard & dr. D.M. Deng, start: 2015.

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Sprangers SL. Osteoclasts and their precursors. Supervisor: prof. dr. V. Everts; co-supervisor: dr.ir. T.J. de Vries, start: 2014. Tabeian H. The role of cytokines and mechanical loading in the degeneration of the temporomandibular joint. Supervisors: prof.dr. V. Everts & prof.dr. F. Lobbezoo; co-supervisors: dr. A.D. Bakker & dr.ir. T.J. de Vries, start: 2012. Tastepe C.S. Peri-implantitis and implant cleaning methods. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. Y. Liu, start 2012. Tauböck TTKJ. Influence of light curing protocols on dental restorative resin composite material. prof.dr. A.J. Feilzer & prof.dr. T. Attin, start: September 2012. Ten Harkel B. Multinucleated giant cells versus osteoclasts. Supervisor: prof.dr. V. Everts; co-supervisor: dr.ir. T.J. de Vries, start: December 2011. Thymi M. Effects of mechanical loading on implant stability. Supervisors: prof.dr. F. Lobbezoo & prof.dr. D. Wismeijer; co-supervisor: dr. C.M. Visscher, start: 2014. Tuijt M. The role of muscle function in internal derangements of the temporomandibular joint. Supervisor: prof.dr. F. Lobbezoo; co-supervisor: dr.ir. J.H. Koolstra, start: 2004. Tuk JC. Anxiety and pain related to oral and maxillofacial surgery. Supervisor: prof.dr. J. de Lange; co- supervisors: dr. J.A.H. Lindeboom & dr. A.J. van Wijk, start: September 2012. Van den Bergh B. Epidemiology and treatment of mandibular trauma. Supervisors: prof.dr. T. Forouzanfar & prof.dr. D.B. Tuinzing; co-supervisor: dr. J.J. de Mol van Otterloo, start: 2009. Van der Kaaij, NCW. Prevention of white spot lesions. Supervisor: prof.dr. J.M. ten Cate; co-supervisors: dr.ir. M.H. van der Veen & dr. E. Zaura, start: 2009. Van der Sleen, J. Dento-alveolaire chirurgie. Supervisor: prof.dr. J. de Lange, start: April 2012. Van der Zande MM. What aspects play a role in Dentist’s decision making when looking at implementing digital tools into their practice. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. R.C. Gorter, start: 2013. Van Eekeren PJA. Het klinisch effect van de keuze voor bone of soft tissue level implantaten. Supervisor: prof.dr. D. Wismeijer; co-supervisors: dr. A. Tahmaseb & Tio, start: 2012. Van Esterik FAS. Bioresorbable materials for scaffolds in oral in oral regenerative medicine. Supervisors: prof.dr. J. Klein-Nulend & prof.dr. C.J. Kleverlaan, co-supervisor: dr. B. Zandieh Doulabi, start: October 2012. Van Grootel RJ. Vergelijken Fysiotherapie en splint bij TMD patienten. Supervisor: prof.dr. D. Wismeijer; co- supervisor: dr. H.W. van der Glas, start: 2014. Van Velzen FJJ. Risk factors and complications in oral and maxillofacial implantology. Supervisors: prof.dr. C.M. ten Bruggenkate & prof.dr. E.A.J.M. Schulten, start: 2010. Veldhuizen R. In vitro assessment of titanium allergy. Supervisors: prof. dr. S. Gibbs & prof.dr. A.J. Feilzer; co- supervisor: dr. C.J. Kleverlaan, start: 2014. Wang D. Osseoiductive membrane. Supervisor: D. Wismeijer; co-supervisor: dr. Y. Liu, start: 2012 end 2016. Wetselaar P. The tooth wear evaluation system. Development and applications. Supervisor: prof.dr. F. Lobbezoo; co-supervisors: dr. C.M. Visscher & dr. M. Koutris, start 2013. Zamani Y. Development of functional scaffolds for bone tissue engineering using 3D printing of cells and biomaterials. Supervisors: prof.dr.ir. G. Amoabediny (Tehran University, Iran) & prof.dr. J. Klein-Nulend (ACTA), co-supervisors: dr. B. Zandieh Doulabi (ACTA) & dr. M.N. Helder (Orthopaedics, Vumc), start: 2015. Zhang X. Icarin as an alternative for BMP-2. Supervisor: D. Wismeijer; co-supervisor: dr. Y. Liu, start: 2012. Zembic A. The 2 implant overdenture in the maxilla. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2012. Zygogiannis K. Mini dental implants versus narrow diameter implants: The implant retained mandibular overdenture. Supervisor: prof.dr. D. Wismeijer; co-supervisor: dr. A. Tahmaseb, start: 2012.

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Societal impact The societal impact of the programme is evident by, among others, the impact on patient care, interactions with the industry and other non-university groups, the impact on professionals, and relevant (inter-)national functions. The research program also contributes to the post-graduate training programs. The research on overloading and pain of the musculoskeletal structures of the masticatory system has direct impact on the quality of diagnostic procedures and of patient care, and extends its influence towards an improvement of the (oral-) health-related quality of life. The implications of this research are not only important for general orofacial pain patient groups, but also for more vulnerable populations like those suffering from dementias and otherwise impaired cognitive abilities. An ambitious future goal of the program is to improve health care and treatment of patients with juvenile idiopathic arthritis. Diagnosis of arthritis of the jaw joint is commonly missed by clinicians, eventually possibly leading to progressive pain and malfunctioning of the joint. Research started in 2012 is focused on learning the biological parameters of the three types of cartilage present in the jaw joint. Inflammation will be mimicked in vitro and it will be determined whether mechanical loading will lead to a decreased inflammation. Special focus is on orthodontic patients with cranio-facial deformities and/or related malocclusions. A program of quality of life related to this topic is carried out. During the last couple of years it became clear that implanted materials like metals can have adverse effects like inflammation, irritation, allergy. The local and systemic effects of leachables from dental implants is now an important issue of investigation. The safety assessment (hazard identification) resulting from an improved understanding how dental implants influence the local and systemic environment will have an enormous impact on the society. The development of physiologically relevant human models to replace or reduce the use of animals (3Rs) to investigate oral wound healing, healthy and pathogenic biofilm and adverse effects of dental materials has a huge societal and political impact in Europe . The societal impact of the research on oral and maxillofacial radiology is focused on the improvement of diagnostic imaging procedures. This relates to not only technical parameters, but also other factors that influence the diagnostic performance of radio-diagnostic procedures, such as the effect of viewing conditions and observer characteristics. Part of the activities includes continuing education courses on the safe use of radiation in dental practice and application of digital imaging in dentistry. Enamel fluorosis is an increasing aesthetic problem in several countries. The project on mechanism of enamel fluorosis adds to our understanding how these defects develop which will help to prevent these defects in future. The results of our research on bone adaptation and regeneration will offer multiple opportunities for the development of new therapeutic agents to prevent (inflammation-associated) unwanted clinical bone loss, thereby preventing among others mobility loss with aging. The design of dental implants differs between brands and indication areas. On the other hand de design van also have an influence on the reaction of bone and soft tissue surrounding the dental implant . Research in this area can help develop redesign the implant abutment interface but also influence the success of the present generation of implants. Research looking at a minimal invasive approach in the treatment of patients with over dentures using reduced diameter implants (1.8-2.4 mm in diameter) shows us that this approach opens new doors for the treatment of those patients that due to medical conditions or lack of bone volume were exempted from treatment. After years of in vitro study on calcium Phosphate and absorbed BMPs in bone regeneration an ZonMw grant has been gained with which together with industry it is now possible to take the final step and fine tune the product to take it to the clinic. The research is now focussed on getting the CE registration for this product making it one of the first bioactive bone regenerative products allowed to be used in patient treatment. 3D printing crown and bridge work in composite resins or ceramic materials is a future approach on the production of prosthetics in dentistry. Together with industry we are involved with the devolvement of both 3D printing processes. A novel approach in tooth replacement with dental implants is individually designing the implant based on the CBCT scan and the milling or printing it. The tooth root is then extracted and the individual implant is inserted into the alveolus. This approach is also part of a patent that ORM has acquired in which the individualisation of dental implant design tailored to the individual patient which is then printed in either titanium or a ceramic material including the individual drill guide and tooling. Using this approach there are a lot less limitations in shape or form of dental implants.

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The societal impact of the clinical research on oral and maxillofacial surgery is focussed on the influence on patient care, both within the department and externally. Research contributes to improved treatment of relevant patient groups.

I. Societal relevance for the dental professional in the Netherlands

Courses organized for Dutch dental and medical professionals Berkhout, W.E.R. Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar – tandheelkunde 19 March; 12 May; 15-16 October; 10 December. Berkhout, W.E.R. - Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT, March; 11-26 June; 1-16 October. Berkhout, W.E.R. Stralingshygiënisch Gekwalificeerd Beroepsbeoefenaar mbt CBCT, variant MKA, 5-19 June; 26 November; 4 December. De Lange, J. QP MKA-chirurgie, Utrecht: 31/1 and 14/2. De Lange, J. QP Edentate patiënt, Amsterdam: 28/11 and 12/12. Dubois, L. Refereeravond AMC: medicatiegebruik in de Tandheelkunde, 27 January, 2015. Dubois, L. Refereeravond St. Antonius ziekenhuis: Mentale Kracht, 13 October, 2015. Dubois, L. MKA 3D dag, 12 December, 2015. Gilijamse M. & Berkhout, W.E.R., Cursus Conebeam CT voor MKA-chirurgen. ACTA Dental Education BV, Amsterdam. Lobbezoo, F., Koutris, M. Organisatie QP Mondhygiëne themadag Pijn: van bron tot brein. (Amsterdam, 21 November 2015). Lobbezoo, F., Wetselaar, P. Organizing committee. Jaarcongres Nederlandse Vereniging voor Gnathologie en Prothetische Tandheelkunde (NVGPT) Kauwen op bruxisme - de nieuwste inzichten en praktische implicaties. Ermelo, 10-11 December 2015. Wetselaar P. Organisatie en moderatie Quality Practice-assistenten Update-dag, Utrecht, November 13, 2015 Wismeijer, D.: Congress Quality practice rondom orale implantologie 21/28 March 2015.

Lectures given during courses for Dutch dental and medical professionals Aarab G. TMD-pijn: de rol van de mondhygiënist. QP Mondhygiëne, Amsterdam, the Netherlands, November 21, 2015. Aarab, G. Een snurker in de stoel. QP Assistenten Update dag, Utrecht, the Netherlands, November 13, 2015. Baart, J.A. Lokale anesthesie voor assisterenden. VUmc/ACTA Amsterdam, 21-05-2015. Baart, J.A. Lokale anesthesie voor assisterenden. Garderen, 06-06-2015. Baart, J.A. Symptomen en Syndromen, ZLTV Maastricht,19-06-2015. Baart, J.A. Lokale anesthesie voor assisterenden. VUmc/ACTA Amsterdam, 25-06-2015. Baart, J.A. Dento-alveolaire chirurgie voor algemeen practici. ACTA Dental Education, Amsterdam, 26-06-2015. Baart, J.A. Lokale en algehele anesthesie voor kaakchirurgische behandelingen bij kinderen. VUmc afd. anesthesie, Amsterdam,29-06-2015. Baart, J.A. Lokale anesthesie voor assisterenden VUmc/ACTA Amsterdam, 24-09-2015. Baart, J.A. Dento-alveolaire chirurgie voor algemeen practici. ACTA Dental Education, Amsterdam, 25-09-2015. Baart, J.A. Lokale anesthesie voor assisterenden. Garderen, 03-10-2015. Baart, J.A. Kaakchirurgische geassisteerde orthodontie. ACTA afd. orthodontie AIO’s. Amsterdam 10-10-2015. Baart, J.A. Tandletsel, Bussum, 30-10-2015. Baart, J.A. Lokale anesthesie bij kinderen. ACTA-DE, Amsterdam, 13-11-2015. Baart, J.A. Pijnbestrijding tijdens en na MH behandeling. ACTA-DE, Amsterdam, 21-11-2015. Baart, J.A. Uitbreiding dentogene ontsteking en kleine verrichtingen in de algemene praktijk. Edudentaal, Den Haag, 26-11-2015. Baart, J.A. Dentoalveolaire chirurgie in de algemene praktijk. ACTA-DE, Amsterdam, 04-12-2015. Baart, J.A. Symptomen en syndromen, orthodontisten in opleiding. ACTA, 09-12-2015. Baart, J.A. Enkele aandoeningen van de kleine speekselklieren. Trippenhuis, Amsterdam, the Netherlands, Mond- en kaakziekten voor pathologen en kaakchirurgen. September 4, 2015. Baart, J.A. Pijn in het gebruik van pijnstillers. Nijmegen, the Netherlands, UMC Radboud PAOT. April 10, 2015

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Becking, A.G. Klinische avond voor MKA-chirurgen en orthodontisten Midden-Brabant. Laatste inzichten in diagnostiek en behandeling van condylaire hyperplasie. Breda, 15 September. Berkhout W.E.R. Intercongress, Radiologie en stralingshygiëne, Curaçao, 27 January 2015. Berkhout W.E.R. Dental Best Practice. Stralinghygiënisch Gekwalificeerd Beroepsbeoefenaar,15 January 2015. De Lange, J. Derde molaren en apexresecties; Indicatiestelling en behandeluitkomsten. Quality Practice Jaarbeurs Utrecht 31/1 and 14/2. De Lange, J. Apexresectie of herendo? Quality Practice Jaarbeurs Utrecht 31/1 en 14/2. De Lange, J. Reconstructie van de edentate bovenkaak. Quality Practice, ACTA Amsterdam 28/11 and 12/12. De Lange, J. Traumatologie bij de edentate patiënt. Quality Practice, ACTA Amsterdam 28/11 en 12/12. De Lange, J. Geïmpacteerde elementen; evidence based management? Voorjaarsvergadering NvVO 27/3. De Lange, J. Bimaxillaire osteotomie als therapie voor OSAS. KNO minisymposium. Olympus Zoeterwoude 16/10. Dubois, L. Aangezichtstraumatologie, ACTA Quality Practice, jaarbeurs Utrecht, 31 January 2015 and 14 February 2015. Dubois, L. Dento-alveolaire traumatologie, ACTA Quality Practice, 31 januari 2015 and 14 februari 2015, jaarbeurs Utrecht Dubois, L. Innovaties in de traumatologie, VMTI studentencongres, ACTA Amsterdam, 12 June 2015. Dubois, L. Traumatologie: face first!, Assistentendag St. Antonius ziekenhuis, Nieuwegein, 9 October 2015. Dubois, L. NOMA, parodontitis extravaganza, NVMKA, Amersfoort, 6 November 2015. Dubois, L. Computer assisted surgery, 3D dag, MKA 3D dag, AMC Amsterdam, 12 December. Dubois, L. Intra-operatieve navigatie, MKA 3D dag, AMC Amsterdam, 12 December. Dubois, L. Workshop navigatie, MKA 3D dag, AMC Amsterdam, 12 December. Koutris M. Workshop Verschillende soorten orofaciale pijn, QP Assistenten Updatedag, Utrecht, the Netherlands, November 13, 2015. Koutris M. Neuropathische pijn, QP Mondhygiëne, Amsterdam, the Netherlands, November 21, 2015. Lobbezoo F. Wat is pijn? QP Mondhygiëne themadag Pijn: van bron tot brein, Amsterdam, November 21, 2015. Lobbezoo F. Het hoe en waarom van verwijzen bij aangezichtspijn. QP Mondhygiëne themadag Pijn: van bron tot brein, Amsterdam, November 21, 2015. Rollman, A. Fysiotherapie in de tandheelkunde. QP Assistenten Update dag, ADE, Utrecht, the Netherlands, November 13, 2015. Schulten E.A.J.M. Dentogene tumoren: behandeling en reconstructie. Tijdens Mondpathologie: Nascholingscursus voor kaakchirurgen en pathologen. Het Trippenhuis, Amsterdam, 04-09-15. Schulten E.A.J.M. Docent NVOI-cursus De Verdieping (26-27 November 2015). Schulten E.A.J.M. Docent ACTA-DE cursus Dento-alveolaire chirurgie voor tandartsen (vanaf 2013). Schulten, E.A.J.M. Orale rehabilitatie na tumorbehandeling. Amsterdam, the Netherlands, Benecke-cursus Oncologie in de tandartsenpraktijk. Aristo. December 11, 2015. Tahmaseb, A. Creating the virtual patient: how to integrate facial, optical and radiological imaging components. Amsterdam, the Netherlands, ADE course The edentulous patient, 26 September 2015. Tahmaseb, A. ITI Cadaver Course, Rotterdam, the Netherlands, 21 January 2015. Tuinzing, D.B. De sagittale splijtingsosteotomie. SRO, Leiden. 15-5-2015. Van Daelen, A.C.L. Person to person, klinische cursus implantologie chirurgie en prothetiek (live surgery), Tendens tandartsen, Amsterdam, samen met R. Goené. 24 January 2015. Van Daelen, A.C.L. Person to person, klinische cursus implantologie chirurgie en prothetiek (live surgery), Tendens tandartsen, Amsterdam, samen met R. Goené. 21 March 2015. Van Daelen, A.C.L. De bovenbouw, cursus NVOI, Haarlem samen met R. Goené en H. Meijer. 18 June 2015 Van Daelen, A.C.L. Person to person, klinische cursus implantologie chirurgie en prothetiek (live surgery), Tendens tandartsen, Amsterdam, samen met R. Goené. 20 June 2015. Van Daelen, A.C.L. De bovenbouw, cursus NVOI, Eindhoven. Samen met R. Goené en Prof. H. Meijer. 23 June 2015. Van Daelen, A.C.L. De bovenbouw, cursus NVOI, Haarlem. Samen met R. Goené en Prof. H. Meijer. 10 September 2015. Van Daelen, A.C.L. Voordracht: Schoonheid in Tandheelkunde. Symposium Bijlmerparktheater, Amsterdam. Samen met S. van Teeseling en R. Goené. 11 September 2015. Van Daelen, A.C.L. Implantaten: 1e keus, VPM-congres, Ede. Samen met R. Goené, S. van Teeseling en Prof. G. Raghoebar. 18 September 2015.

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Van Daelen, A.C.L. De bovenbouw, cursus NVOI, Houten. Samen met R. Goené en Prof. H. Meijer. 29 September 2015. Van Daelen, A.C.L. Hands-on cursus, Delft: Immediaat tandvervanging in de esthetische zone. 14 October 2015. Van Daelen, A.C.L. Person to person, klinische cursus implantologie chirurgie en prothetiek (live surgery), Tendens tandartsen, Amsterdam, samen met R. Goené. 28 November 2015. Van Daelen, A.C.L. Hands-on cursus, Delft: Immediaat tandvervanging in de esthetische zone. 2 December 2015. Van der Kaaij, NCW. Orthodontie voor kindertandartsen. Postacademische opleiding pedodontologie, ACTA, 30 April and 11 June 2015. Van Loon, J.J.W.A. Sensing changes of the gravitational load (from cells to organisms and beyond): Technical and physiological aspects of plant life in space. Amsterdam, the Netherlands, VU, college@Extreme Biology course. November 27, 2015. Visscher, CM. Mondgewoonten – is dat erg? QP Mondhygiëne, Amsterdam, the Netherlands, June 27, 2015. Visscher CM. Hoofdpijn. QP Mondhygiëne, Amsterdam, the Netherlands, November 21, 2015. Wetselaar P. Gebitsslijtage van diagnostiek tot behandeling. Dental Studie Update Congres, Associatie Nederlandse Tandartsen, Amsterdam, February 07, 2015 Wetselaar P. Gebitsslijtage. Studiegroep ’t Gooi, Muiden, October 27, 2015 Wetselaar P. Gebitsslijtage, herkennen en een cijfer geven. QP Assistenten Update dag, Utrecht, November 13, 2015 Wetselaar P. Orofaciale Pijn. ADE Assistentendag, Amsterdam, November 21 & 27, 2015. Wismeijer, D. Implanteren in de algemene praktijk met het Straumann® Dental Implant System Hazerswoude – Rijndijk, Dagcursus, 9 January 2015. Wismeijer, D. ADE Cursus Nazorg in de orale implantologie : Periimplantitis Een chirurgische benadering, 30 January 2015. Wismeijer, D. QP lezing Periimplantitis A surgical approach, 6 March 2015. Wismeijer, D. Een implantaat de oplossing voor elk diasteem? Congress Quality practice, 21 March 2015. Wismeijer, D. Toekomstverwachtingen in de orale implantologie. QP dag Een implantaat de oplossing voor elk diasteem? 21 March 2015. Wismeijer, D. Een implantaat de oplossing voor elk diasteem? Congress Quality practice, 28 March 2015. Wismeijer, D. Game Changers in de Tandheelkunde. KNMT studenten congres, 2 October 2015. Wismeijer, D. Niet meer weg te denken 3D/Bot. KVPA Lustrum congress It´s showtime!, 16 October 2015. Wismeijer, D. Implantaten en de edentate patient. ADE course The edentulous patient, 12-13 November 2015. Wismeijer, D. Implantaten en de edentate patiënt. Amsterdam, the Netherlands, ADE course The edentulous patient, 12 November2015.

Organization of congresses and symposia for professionals in the Netherlands Schulten, E.A.J.M. Organizer. Implantologie à VU avondsymposium: Wikken en Wegen: Amstelzaal VUmc, Amsterdam, the Netherlands (2015, June 02). Schulten, E.A.J.M. Organizing committee. De geatrofieerde edentate kaak: nog niet het einde. Symposium voor tandprothetici i.s.m. Straumann Nederland: ACTA, Amsterdam the Netherlands (2015, June 12). Visscher, C.M.: Organizer. Symposium TMD-doedag voor fysiotherapeuten: ADE, Amsterdam, the Netherlands (2015, November 07). Wismeijer, D. (2015, November 06). Organizer symposium afscheid Joep Laverman.

Invited speakers at professional congresses or symposia in the Netherlands Aarab, G. (2015, November 07). 1. Slaapapneu: red alerts en consequenties voor de dagelijkse praktijk. 2. Workshop Diagnostiek. 3. Workshop Oefentherapie. Amsterdam, the Netherlands, Symposium TMD- doedag voor fysiotherapeuten, ADE. Aarab, G. (2015, December 11). Associaties van bruxisme met slaapapneu en andere slaapstoornissen. Ermelo, the Netherlands, Jaarcongres NVGPT. Baart, J.A. (2015, September 10). Tandheelkunde Up to date. Maastricht, the Netherlands, Congres. Berkhout, W.E.R. (2015, April 10). Röntgendiagnostiek met de panorama-opname. the Netherlands, Congres Nederlandse Vereniging Tandheelkundige Slaapgeneeskunde.

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Berkhout, W.E.R. (2015, February 07). Zin en onzin rond KEW en praktijkrichtlijn. the Netherlands, Jaarcongres ANT. Forouzanfar, T. (2015, April 16). 3D Innovatie Lab. Amsterdam, the Netherlands, Heilig VU-uur. Gilijamse, M. (2015, May 06). Aangezichtsletsel bij kinderen. Insperience Centre Vianen, the Netherlands, Congres Tandletsel bij kinderen – je kunt meer dan je denkt. Koutris, M. (2015, March 18). DC-TMD, Axis I. ACTA, Amsterdam, the Netherlands, Regular meeting Dutch Gnathologists. Koutris, M. (2015, November 07). 1. Neuropatische pijn. 2. Workshop Diagnostiek. 3. Workshop Oefentherapie. Amsterdam, the Netherlands, Symposium TMD-doedag voor fysiotherapeuten, ADE. Kuitert, R.B. (2015, September 24). Kwaliteit, corrosie, erosie, abfractie, slijtage, vervorming en porositeit en verval van klinisch gebruikte brackets en bogen. Dalfsen, the Netherlands, NVVO najaarscongres 24-25 September. Kuitert, R.B. (2015, May 15). Long term stability after surgical orthodontics. Leiden, the Netherlands, 26th EBSO congress 13-16 May. Lobbezoo, F. (2015, March 18). DC/TMD expandend. Amsterdam, the Netherlands, Sectie Tandarts- Gnatholoog, NVGPT. Lobbezoo, F. (2015, November 07). 1. Kauwen op bruxisme. 2. Workshop Diagnostiek. 3. Workshop Casuïstiek. Amsterdam, the Netherlands, Symposium TMD-doedag voor fysiotherapeuten, ADE. Lobbezoo, F. (2015, December 11). Definities en diagnostiek van bruxisme: state-of-the-art. Ermelo, the Netherlands, NVGPT-jaarcongres. Loomans, B. & Wetselaar, P. (2015, February 18). Gebitsslijtage, een strategie voor de algemene praktijk. Hilversum, the Netherlands, Webinar Koninklijke Nederlandse Maatschappij Tandheelkunde. Rollman, A. (2015, November 07). 1. Workshop Diagnostiek. 2. Workshop Oefentherapie. Amsterdam, the Netherlands, Symposium TMD-doedag voor fysiotherapeuten, ADE. Schulten, E.A.J.M. (2015, January 09). Bot, de bindende factor – Over bot(re)generatie, implantaten en passie. Leiden, the Netherlands, Symposium afscheid prof.dr. C.M. ten Bruggenkate (Rijnland Ziekenhuis Leiderdorp) Corpus. Schulten, E.A.J.M. (2015, December 17). Het gebruik van stamcellen bij bot(re)generatie in het cranio-maxillo- faciale gebied. Hotel de Ruwenberg, Sint-Michielsgestel, the Netherlands, Refereermiddag voor tandartsen; op uitnodiging van maatschap MKA in MC Jeroen Bosch, Den Bosch. Schulten, E.A.J.M. (2015, June 02). Wikken en wegen. Amsterdam, the Netherlands, 6e Implantologie à VU avondsymposium, Amstelzaal VUmc. Schulten E.A.J.M. (2015, June 12). De geatrofieerde edentate kaak: nog niet het einde. Amsterdam, the Netherlands, Symposium voor Tandprothetici i.s.m. Straumann Nederland. ACTA. Tuinzing, D.B. (2015, October 01). Chirurgische kaakorthopedie. Zonnestraal, Hilversum, the Netherlands, Afscheid Dorenbos. Van Daelen, A.C.L. (2015, June 02). Implantologie a VU, symposium VU Amsterdam met interdisciplinair team VUmc (i.s.m. met R. Goené, S. van Teeseling, Prof. B. Schulten, Prof.Ch. ten Bruggenkate). Van Daelen, A.C.L. (2015, September 03). Voordracht EPA congres, Praag voor examencommissie ter verkrijging titel: “EPA-prosthodontist”. Van der Stelt, P.F. (2015, January 30). Is meer altijd beter? Apeldoorn, the Netherlands, Hoytemastichting, Onder Professoren IX. Van Loon, J.J.W.A. (2015, July 22). Hypergravity for Life Sciences Research and Applications: The Human Hypergravity Habitat (H3) and Large Diameter Centrifuge (LDC). Universiteit Maastricht, the Netherlands. Van Loon, J.J.W.A. (2015, September 22). RPM for ‘beginners'. Leiden, the Netherlands, Hogeschool Leiden. Visscher, C.M. (2015, November 07). 1. Inleiding TMD diagnostiek. 2. Workshop Diagnostiek. 3. Workshop Oefentherapie. Amsterdam, the Netherlands, Symposium TMD-doedag voor fysiotherapeuten, ADE. Warnsinck, J. (2015, November 07). 1. Workshop Diagnostiek. 2. Workshop Oefentherapie. Amsterdam, the Netherlands, Symposium TMD-doedag voor fysiotherapeuten, ADE. Wetselaar, P. (2015, November 07). 1. Workshop Diagnostiek. 2. Workshop Casuïstiek. Amsterdam, the Netherlands, Symposium TMD-doedag voor fysiotherapeuten, ADE. Wetselaar, P. (2015, December 11). Bruxisme, de grootste schurk in de tandheelkunde? Ermelo, the Netherlands, NVGPT-jaarcongres.

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Professional functions in the Netherlands Baart, J.A.: Member redactieraad - Geneesmiddelenbulletin. Baart, J.A.: Board member - Nederlandse Vereniging van Tandartsen. Baart, J.A.: Chair - WTA. Becking, A.G.: Lid - Centrale Opleidingscommissie, Kennemer Gasthuis, Haarlem. Becking, A.G.: Lid - Commissie onderzoek en aanbeveling NVMKA. Becking, A.G.: Lid - Concilium Chirurgicum Oris (CCO). Becking, A.G.: Lid - Implementatie commissie competentiegericht opleiden MKA, Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie (NVMKA). Becking, A.G.: Voorzitter - Maatschap MKA Kennemerland. Becking, A.G.: Medisch manager - MKA, Kennemer Gasthuis, Haarlem. Becking, A.G.: Opleider - Perifere deelopleiding MKA, Kennemer Gasthuis, Haarlem. Becking, A.G.: Lid - Stipendium commissie BOOA research grant, NVMKA. Berkhout, W.E.R.: Member - College van Opleiders Stralingsopleidingen 2013-. Berkhout, W.E.R.: Advisor - KNMT inzake praktijkrichtlijn Radiologie 2015-. Berkhout, W.E.R.: Member - Raad van Commissarissen Nederlands Tijdschrift voor Tandheelkunde 2013-. Berkhout, W.E.R.: Member - Redactieadviesraad ACTA QP. Berkhout, W.E.R.: Coördinerend stralingsdeskundige - VU-ACTA Amsterdam 2013-. De Lange, J.: Lid - Capaciteitsorgaan. De Lange, J.: Lid - CKC KNMT. De Lange, J.: Lid - COK. De Lange, J.: Lid - Concilium Chirurgicum Oris (CCO). De Lange, J.: Voorzitter - CTS. De Lange, J.: Bestuurslid (inkomend voorzitter) - NVMKA. Disse, M.A.: Dutch representative (member) - Efosa. Disse, M.A.: Vice-president - RTS. Disse, M.A.: Member - The Amsterdam Cleft Lip and Palate team, location VUmc/ACTA. Dubois, L.: Secretaris - Bridge the Gap Foundation. Dubois, L.: Lid - Protocollen aangezichtsletsel NVMKA. Dubois, L.: Lid - Richtlijncommissie spoedoperaties, Nederlandse Vereniging voor Heelkunde en Kwaliteitsinstituut Medisch Specialisten. Kramer, G.J.C.: Member - Schisisteam MCA Alkmaar. Kramer, G.J.C.: Chair/secretary - Special Interest group ortodontics NVSCA. Kuitert, R.B.: Member - Centraal College. Kuitert, R.B.: Member - Concilium Orthodonticum. Kuitert, R.B.: Member - European Teachers' Forum. Kuitert, R.B.: Member - Nebeop/visiting assessment committee. Lobbezoo, F.: Chair - Curatorium Bijzondere Leerstoel Angst- en Gedragsstoornissen in de Tandheelkundige Praktijk, since 2014. Lobbezoo, F.: Chair - Curatorium Bijzondere Leerstoel Kwaliteit van Mondzorg, since 2015. Lobbezoo, F.: Chair - Curatorium Bijzondere Leerstoel Mondgezondheid en Kwaliteit van Leven, since 2015. Lobbezoo, F.: Member - Interim Management Team MOVE Research Institute Amsterdam. Lobbezoo, F.: Plaatsvervangend lid - Universitaire Onderzoekscommissie (UOC), Universiteit van Amsterdam, since 2013. Prahl, C.: Board member - Stichting ter bevordering van de orthodontie. Van Daelen, A.C.L.: Mondonderzoeker - Centrale klachtencommissie KNMT. Van Daelen, A.C.L.: Member visitatiecommissie tandarts-implantoloog - NVOI. Van Daelen, A.C.L.: Member opleidingscommissie - NVVRT (opleiding Restauratief tandarts). Van der Kaaij, N.C.W.: Member - Schisisteam Erasmus MC Sophia kinderziekenhuis. Van der Stelt, P.F.: Director - Nederlands Tijdschrift voor Tandheelkunde BV, Houten 2005-.

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Van der Stelt, P.F.: Chair - Stichting Bevordering Tandheelkundige Kennis, Houten 2005-. Van der Stelt, P.F.: Member - Werkgroep herziening Praktijkrichtlijn Radiologie, KNMT, Nieuwegein 2013-2015. Wismeijer, D.: Visitator - NVOI praktijk visitaties herregistratie.

II. Societal relevance for the dental professional internationally

Professional functions internationally Becking, A.G.: Visiting surgeon - CIPTO Mangukusomo Hospital, Jakarta, Indonesia. Becking, A.G.: President - SORG (Strasbourg Osteosynthesis Research Group). Becking, A.G.: Visiting Professor - Universitat International Catalunya, Spain. De Lange, J.: Faculty member - AOCMF. De Lange, J.: Faculty member - SORG. Wismeijer, D.: Board member responsible for training and education - International Team for Implantology (ITI). Wismeijer, D.: Chair - Training and Education committee International Team for Implantology (ITI).

Invited speakers at international professional congresses or symposia Becking, A.G. (2015, April 11). 1. Contemporary concepts in diagnosis and treatment of condylar hyperplasia. 2. Transoral zygoma sandwich osteotomy in orthognatic surgery. 3. Growth and interception in class 3 deformity. Barcelona, Spain, Universidad International Catalunya. Becking, A.G. (2015, May 15). 2D and 3D digital and virtual planning in orthognatic surgery. Boddlwyddn, UK, hands-on workshop on planning OGS. Becking, A.G. (2015, November 02). 2D and 3D digital virtual planning in orthognatic surgery. Sydney, Australia, Orthodontic department, Dental School. Becking, A.G. (2015, March 31). Case presentations syngnathia. Paris, France, Symposium on syngnathia, Necker Hospital. Becking, A.G. (2015, October 26). Computer-assisted planning and surgery, the basics. Melbourne, Australia, SORG pre-conference course on Patients specific solutions, ICOMS. Becking, A.G. (2015, November 12). Transoral zygoma osteotomy in reconstructive and aesthetic surgery. Ferrara, Italy, FACE 2015. Becking, A.G. (2015, 26 November). Zygoma sandwich osteotomy and orthognatic surgery. Haarlem, the Netherlands, Biannual Symposium Surgical Orthodontics (BSSO). Berkhout, W.E.R. (2015, September 04). Tandheelkundige radiologie. Brussel, Belgium, Nascholingsinstituut van de Vlaamse Vereniging voor Tandartsen (VVT). De Lange, J. (2015, September 26). Bimaxillary protrusion osteotomy for treatment of obstructive sleep-apnea. Amsterdam, the Netherlands, EACD, ACTA. De Lange, J. (2015, May 07). Updates in management of central giant cell lesions of the maxillofacial skeleton. Chicago, USA, AAOMS Research Summit. Dubois, L. (2015, March 25). 1. Predictability in orbital reconstruction. 2. Patient specific implants. Tuttlingen, Germany, KLS Martin. Dubois, L. (2015, November 02). CAS for orthognatic surgery. Sydney, Australia, University of Sydney. Dubois, L. (2015, October 26). New technological developments to raise the predictability of orbital reconstruction. Melbourne, Australia, SORG preconference course ICOMS. Dubois, L. (2015, November 11). Orbital floor repair with PSI vs 3D implants. Implants knowledge in CMF- experts in dialogue. Germany, Tuttlingen. Dubois, L. (2015, January 23). Orthognatic surgery. Vientiane, Laos, Dental School. Tahmaseb, A. (2015, December 11). 4 lectures. Lebanon, Lebanese ITI section. Tahmaseb, A. (2015, February 18). Lecture. Amsterdam, the Netherlands, French ITI meeting. Tahmaseb, A. (2015, April 17). Lezing voor Vlaamse wetenschappelijke organisatie. Knokke, Belgium, VWVT cursus Belgische tandartsen. Tuinzing, D.B. (2015, November 27). The generation, Wales in BSSO. Haarlem, the Netherlands, BSSO symposium.

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Van der Stelt, P.F. (2015, October 16). Digitale radiologie, theorie en praktijk. Antwerpen, Belgium, Nascholingsinstituut van de Vlaamse Vereniging voor Tandartsen (VVT). Wismeijer, D. (2015, April 17). 1. Esthetiek in de implantologie. 2. Periimplantitis. 3. Patiëntencasussen. Knokke, Belgium, VWVT cursus voor Belgische tandartsen. Wismeijer, D. (2015, October 21). Digital dentistry. Where is this all taking us. Hong Kong, World Dental forum. Wismeijer, D. (2015, March 19). The future of digital dentistry. Amsterdam, the Netherlands, QP 1,5 cursusdag voor Franse tandarts implantologen. Wismeijer, D. (2015, June 25). Treating periimplantitis. Belgrado, ITI studyclub. Wismeijer, D. (2015, June 4-6). Course on Digital dentistry. Druids Glen resort Newtown Mount Kennedy Wicklow, Ireland.

III. Contacts with the general public

Interactions with the press and the general public Aarab, G. (2015). Programma de buitendienst (angst voor de tandarts), Interview NPO 3. Baart, J.A. (2015). From 2,000 to 10,000 taste buds. In search of excellent flavor. Interview Prophyta Annual: 27. Baart, J.A. (2015). Wat is pijn? Interview Katja's body scan. De Lange, J. (2015). Kaakchirurgie in de algemene praktijk: mogelijkheden en beperkingen. Interview ACTA Quality Practice Tandheelkunde 10 (3), 4-6: (2015, January 01). Forouzanfar, T. (2015). 3D Innovatie Lab ontwikkeld meegroeiend oog. Interview Parool. Forouzanfar, T. (2015). 3D Innovationlab, Wint Rapidpro Award 2015. Interview 3D PrintMagazine. Forouzanfar, T. (2015). 3D maakt nieuw leven. Interview Telegraaf. Forouzanfar, T. (2015). 3D printen innovatie in de zorg. Interview BNR-Radio. Forouzanfar, T. (2015). 3D PrintMagazine. Interview Arburg en 3D Innovationlab; nominatie Rapidpro Award. Forouzanfar, T. (2015). Best practice: Nieuwe behandelmethodes met behulp van 3D printing. Interview MicroCentrum. Forouzanfar, T. (2015). Een kunstoog voor kinderen, dat meegroeit met de jonge patiënt en dat zich aanpast aan licht en donker. Interview Telegraaf. Forouzanfar, T. (2015). Kan 3D printen de kwaliteit van leven verbeteren. Interview Pensioen Pro. Gibbs, S. (2015). Bijna zoals een échte huid. Interview in VUmc de specialist, editie 2 http://vumc.instantmagazine.com/de-specialist/mei-2015/#!/gekweekte-huid. Gibbs, S. (2015). Hoge ogen gooien met dierproefvrij onderzoek. Interview by Puck Moll in C2W (Chemisch2Weekblad) Life Sciences nr. 20, 27 November. Gibbs, S. (2015). Meer nauwkeurigheid met minder dieren. Interview in ExperimentNL (2015), p. 88. http://www.nwo.nl/binaries/content/documents/nwo/algemeen/overnwo/publicaties/items/experimentnl/experiment-nl-wetenschap-in-nederland-2015/Experiment+NL-2015_12222015-pdf.pdf. Uitgave van NWO en Quest Gibbs, S. (2015). Het lichaam als bioreactor. Interview Vlaamse EOS Magazine 2015. Gibbs, S. (2015). Kennis van nu. Interview Radio 5 24 April 2015. Gibbs, S. (2015). Sue Gibbs. Interview Trouw 25 April 2015. Gibbs, S. (2015). Nieuw gezicht. Interview Volkskrant 2 May 2015. Lobbezoo, F. (2015). Kauwen op bruxisme. Interview Prof. Frank Lobbezoo over bruxisme: Bruxisme is geen stoornis. SDU Magazine 2015; 2(4) :17-18.

Inaugural lectures Forouzanfar, T. (2015). Kaakchirurgie naar een nieuwe dimensie. Benoeming hoogleraar Mondziekten, Kaak- en Aangezichtschirurgie (2015, February 05). Auditorium, Amsterdam, the Netherlands: Vrije Universiteit Amsterdam. Tuinzing, D.B. (2015, November 19). Chirurgische kaakorthopedie: meer dan op het eerste gezicht lijkt. Aula Vrije Universiteit Amsterdam, the Netherlands, Afscheidsrede hoogleraar Mondziekten, Kaak- en Aangezichtschirurgie VUmc/ACTA.

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Impact of the research on the general public or professionals Oral and Maxillofacial Surgery VUmc. The guidelines for diagnosis and treatment of patients have been adopted by the Dutch association for Oral and Maxillofacial Surgery (Nederlandse Vereniging voor Mondziekten, Kaak- en Aangezichtschirurgie, NVMKA). Berkhout W.E.R. Lead author Position Paper EADMFR: Justification and good practice in using handheld portable dental X-ray equipment: a position paper prepared by the European Academy of DentoMaxilloFacial Radiology (EADMFR). Louropoulou, A., de Waal, Y., Wismeijer, D. & van der Weijden, G.A. (2015). Richtlijn behandeling van Peri- implantaire Infecties. Van der Stelt, P.F. Lead-author Praktijkrichtlijn Tandheelkundige Radiologie, KNMT. Wismeijer, D. & Meijer, G.J. (2015). Gedragsregels betreffende behandeling van patiënten met tandheelkundige implantaten. Een richtlijn.

Functions in public committees Berkhout, W.E.R.: Advisor - RIVM / IGZ inzake onderzoek stralingsbelasting tandheelkunde NL March 2015-2016. Berkhout, W.E.R.: Member - MKA, werkgroep Eindtermen stralingshygiëne. From 24 March. Hoogeveen, R.C.: Chair - ANVS, werkgroep herziening Eindtermen stralingshygiëne tandheelkunde en CBCT April-December.

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Education related research, including other research

Research on Dental Education Associate dean of educational research and development Dr. J.M. Vervoorn Education Institute ACTA, Gustav Mahlerlaan 3004 1081 LA Amsterdam Tel: +31-20-5980438 E-mail: [email protected]

Research objectives In the ACTA faculty of Dentistry research is performed on several aspects of education in dentistry. This includes research on the evaluation of courses within the curriculum, research on new teaching methods, such as the Objective Structured Clinical Examination (OSCE), development and evaluation of a computer aided digital teaching system creating a virtual learning environment including the application of haptics (the Simodont Dental Trainer), the development of virtual teeth and jaws and comparison with biomedical education elsewhere in Europe. The input of academic personnel is limited to staff of the educational institute, and to some members of the various departments. The research should not be considered as a separate programme; however it is intended that this research will increase in the coming years.

Results In 2015 again several experiments have been carried out with respect to choices in the development of the virtual dental trainer. It appeared that availability of force feedback in a dental trainer is essential for good performance. Also the availability of sound seemed to have a positive effect on the appreciation and performance of students though further research is needed to confirm this. Data on inter and intra observer reliability of assessment showed that including calibration in the workflow of an assessment procedure improved the reliability of the assessments. Inter and intra observer reliability in reality as well as virtual reality are rather poor, further research aims to find ways to improve the reliability of assessments.

Academic personnel in 2015 and 2016 Research staff ACTA - OWI and other research (in full time equivalents)

Position Name fte 2015 plan 2016 funding Vervoorn, dr. J.M. 0,10 0,10 3 Staff members education institute Wesselink, prof.dr. P.R. pm pm guest Bakker, drs. D.R. 0,10 0,10 3 PhD students Boer, drs. I.R. de 0,20 0,20 3 Serrano Petrillo, dds. C.M. 0,45 0,45 3 total 3rd funding 0,85 0,85 3 Total research staff

Output Scientific publications (refereed) Brand, H.S., van der Cammen, C.C.J., Roorda, S.M.E. & Baart, J.A. (2015). Tooth extraction education at dental schools across Europe. British Dental Journal, 1:15002. doi: 10.1038/bdjopen.2015.2

103 Annual Research Report 2015

De Boer, I.R., Lagerweij, M.D., Wesselink, P.R. & Vervoorn, J.M. (2015). Evaluation of the appreciation of virtual teeth with and without pathology. European Journal of Dental Education, 19 (2), 87-94. doi: 10.1111/eje.12108

Professional publications Bruers, J.J.M., van Dam, B.A.F.M., Gorter, R. & Eijkman, M.A.J. (2015). Het welbevinden van tandartsen na een klachtenprocedure. Nederlands Tijdschrift voor Tandheelkunde, 122 (1), 41-48. doi: 10.5177/ntvt.205.01.14152 Van der Sanden, W.J.M., Gorter, R. & Tams, J. (2015). Evidencebased klinische praktijkrichtlijnen in de mondzorg 6. Praktijkrichtlijnen in de opleiding tot tandarts. Nederlands Tijdschrift voor Tandheelkunde, 122 (9), 475-482. doi: 10.5177/ntvt.2015.09.15135

Indicators of Esteem

Grants: current projects with external funding Gorter, R.C. & Wismeijer, D. (2015). Digital dentistry in practice; On dentists' interaction with technological transformations. ITI research grant, to the amount of CHF 123.821: (2015, January 01 - 2015, December 31).

Memberships editorial board Gorter, R.C.: European Journal of Dental Education.

Invited speakers at (inter)national congresses or symposia De Boer, I.R. (2015, August 28). Students' performance with and perception of variation of force feedback in a virtual learning environment. Szeged, Hungary, ADEE 41st meeting. Serrano, C. (2015, August 28). Transition to clinical training in dentistry. Szeged, Hungary, ADEE 41st meeting. Vervoorn, J.M. & Wesselink, P.R. (2015, March 11). A virtual learning environment between innovation and evidence. Boston, USA, IADR Symposium Technology Enhanced Learning to Enrich Dental Education 11-14 March. Vervoorn, J.M. (2015, August 11). Benefits of virtual training for all stakeholders in the educational process. Kuta, Indonesia, South East Asia Association for Dental Education (SEAADE) 11-14 August.

Other (inter)national scientific functions Gorter, R.C.: Executive board member - Association for Dental Education in Europe (ADEE), since 2013. Gorter, R.C.: Member - Platform for better oral health in Europe. Vervoorn, J.M.: Chair special interest group - ADEE: Virtual reality in dental education, since 2009. Vervoorn, J.M.: Chair - Simodont Users Meeting.

Collaborations - MOOG inc. Development of the Simodont dental trainer. - 3M – Development of real scans into virtual reality application.

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Current PhD projects Bakker, DR.: Transfer of skills between virtual reality and reality in dental education. Supervisor: prof.dr. P.R. Wesselink; co-supervisor: dr. J.M. Vervoorn. Start: 2010-11. Boer de, IR.: Acceptance of new technologies in dental education. Supervisor: prof.dr. P.R. Wesselink; co- supervisor: dr. J.M. Vervoorn. Start: 2010-11. Serrano Petrillo, CM. Bridging the gap between preclinical and clinical training in dental education. Supervisor: prof.dr. C. van Loveren; co-supervisor: dr. J.M. Vervoorn. Start: April 2015.

Societal impact The societal impact of the research and development is focused on the effect of learning behaviour on learning outcomes and on the implementation of new technologies in education. This involves in particular the research on a computer aided digital learning environment (the Simodont dental trainer).

I. Societal relevance for the dental professional in the Netherlands

Courses organized for Dutch dental and medical professionals Vervoorn, J.M., Wesselink P.R. Introduction in the Use of the Simodont dental trainer, train de trainers course, University of Bergen, Dental School, January 2015, Bergen, Norway.

Invited speakers at “professional” congresses or symposia in the Netherlands Bakker, D.R. (2015, March 18). The ACTA experience, how ACTA uses the Simodont. Alkmaar, the Netherlands, DSSH.

Professional functions in the Netherlands Gorter, R.C.: Vervangend lid Algemene Interfacultaire Ethische Commissie - UvA.

II. Societal relevance for the dental professional internationally

Professional functions internationally Serrano, C.: Assistent professor - Dentistry School - Universidad de Concepcion Chile.

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Appendix 2015

List of SCI journals, their impact factors and the number of ACTA publications in 2015 in each journal

Number of Number of Journal IF publications Journal IF publications ACTA ODONTOL SCAND 1,030 3 INT J MOL SCI 2,862 1 ACTA OTO-LARYNGOL 1,099 1 INT J ORAL MAX IMPL 1,451 3 ACTA OTORHINOLARYNGO 1,640 1 INT J ORAL MAX SURG 1,565 10 AM J DENT 0,850 1 JAMA OTOLARYNGOL 1,794 1 AM J INFECT CONTROL 2,206 1 JAMA PSYCHIAT 12,008 1 AM J NEURORADIOL 3,589 1 J ADHES DENT 1,311 1 AM J ORTHOD DENTOFAC 1,382 1 J ADV PROSTHODONT 0,640 1 AM J PUBLIC HEALTH 4,552 1 J AM DENT ASSOC 2,010 1 ANAEROBE 2,479 1 J APPL CLIN MED PHYS 1,172 1 ANAL CHEM 5,636 1 J BACK MUSCULOSKELET 0,705 1 ANGLE ORTHOD 1,225 1 J BIOMATER TISS ENG 2,066 1 ANN OTO RHINOL LARYN 1,094 1 J BIOMECH 2,751 1 APPL COGNITIVE PSYCH 1,321 1 J BIOMED MATER RES A 3,369 1 ARCH ORAL BIOL 1,735 2 J BIOMED MATER RES B 2,759 1 AUTOIMMUNITY 2,714 1 J CANCER RES CLIN 3,081 1 BIOCHEM BIOPH RES CO 2,297 1 J CELL PHYSIOL 3,839 1 BIOCHEMISTRY 3,015 1 J CLIN EPIDEMIOL 3,417 1 BIOFOULING 3,415 1 J CLIN PERIODONTOL 4,010 11 BIOL CHEM 3,268 2 J CRANIOFAC SURG 0,678 1 BIOL PSYCHOL 3,403 1 J CRANIO MAXILL SURG 2,933 9 BIOMED RES INT 1,579 3 J DAIRY SCI 2,573 1 BIOMED MATER 3,697 1 J DENT RES 4,139 6 BMC GERIATR 1,676 1 J DENT 2,749 2 BMC ORAL HEALTH 1,128 2 J ENDODONT 3,375 4 BONE 3,973 1 J FOOT ANKLE RES 1,462 1 BRAZ ORAL RES 0,937 2 J IMMUNOL 4,922 1 BRIT DENT J 1,082 2 J LAPAROENDOSC 1,335 1 BRIT J CANCER 4,836 1 J MECH BEHAV BIOMED 3,417 1 BRIT J ORAL MAX SURG 1,076 2 J MICROBIOL METH 2,026 1 BRIT J PSYCHIAT 7,991 1 J ORAL MAXIL SURG 1,425 3 CALCIFIED TISSUE INT 3,272 2 J ORAL REHABIL 1,682 8 CARIES RES 2,231 6 J PERIODONTAL RES 2,466 1 CELL PROLIFERAT 3,116 1 J PERIODONTOL 2,706 1 CIRC-CARDIOVASC GENE 4,600 1 J PROSTHET DENT 1,753 1 CLEFT PALATE-CRAN J 1,203 2 J PSYCHOPHARMACOL 3,898 1 CLIN CANCER RES 8,722 1 J TISSUE ENG REGEN M 5,199 1 CLIN IMPLANT DENT R 3,589 3 LANCET INFECT DIS 22,433 1 CLIN INFECT DIS 8,886 1 MATERIALS 2,651 1 CLIN ORAL IMPLAN RES 3,889 6 MAT SCI ENG C MATER BIOL APPL 3,088 1 CLIN ORAL INVEST 2,352 4 MBIO 6,786 1 CLIN OTOLARYNGOL 2,113 1 MED HYPOTHES 1,074 5 COMMUNITY DENT ORAL 2,025 1 MED ORAL PATOL ORAL 1,171 1 CONTACT DERMATITIS 3,747 2 METHODS 3,645 1 CRIT REV ONCOL HEMAT 4,027 1 MICROBIOL-SGM 2,557 1 CURR OSTEOPOROS REP 2,728 2 NEUROUROL URODYNAM 3,128 1 DENT MATER 3,769 3 NUCLEIC ACIDS RES 9,112 1 DENT TRAUMATOL 1,601 2 ORAL ONCOL 3,607 5 DENTOMAXILLOFAC RAD 1,390 4 OR SURG OR MED OR PA 1,261 4 DRUG AGING 2,838 1 PAIN MED 2,339 1 DYSPHAGIA 2,033 2 PEDIATRICS 5,473 1 EUR ARCH OTO-RHINO-L 1,545 4 PHOTODIAGN PHOTODYN 2,014 1 EUR J CANCER 5,417 2 PLASMA SOURCES SCI T 3,591 1 EUR J DENT EDUC 0,938 1 PLOS ONE 3,234 15 EUR J INTERN MED 2,891 1 Q J NUCL MED MOL IM 2,033 1 EUR J ORAL SCI 1,488 5 QUINTESSENCE INT 0,950 2 EUR J ORTHODONT 1,528 1 RADIOLOGY 6,867 1 EUR J PAEDIATR DENT 0,446 1 RADIOTHER ONCOL 4,363 1 EUR J PSYCHOTRAUMATO 1,602 1 RES DEV DISABIL 1,887 1 EUR SPINE J 2,066 1 RHEUMATOLOGY 4,475 1 EUR SURG RES 2,474 1 SCI REP-UK 5,578 1 EXP DERMATOL 3,762 1 SLEEP BREATH 2,482 2 FASEB J 5,043 1 SUPPORT CARE CANCER 2,365 3 FEMS YEAST RES 2,818 1 THER CLIN RISK MANAG 1,469 1 FRONT CELL INFECT MI 3,719 1 TISSUE ENG PART A 4,448 2 HEAD & NECK 2,641 3 TOXICOL APPL PHARM 3,705 1 HEALTH PSYCHOL 3,590 1 TOXICO IN VITRO 2,903 3 IMPLANT DENT 1,464 1 TRIALS 1,731 1 INT ENDOD J 2,971 3 ULTRASTRUCT PATHOL 1,078 1 INT J ADHES ADHES 1,773 1 INT J DENT HYG 1,059 4 Total 267

Academic Centre for Dentistry Amsterdam

Name Index

Name Page Name Page Aarab, dr. G. 66 Cate, prof.dr. J.M. ten 19 Aartman, dr. I.H.A. 20 Chalil, dds. S. 67 Abdel Aziz, dds. M.F.A. 67 Chen, dds. H. 67 Akveld, MSc. N.A.E. 20 Chen, dds. L. 66 Al Hothali, dds. M.M. 20 Chin Jem Sen, drs. J. 66 Alharbi, dds.N.M. 67 Cioccari Oliveira, dds. S. 66 Anssari Moin, drs. D. 20, 67 Crielaard, prof.dr. W. 19 Apperloo, drs. R.C. 66 Daher, dds. R. 67 Ashton-James, dr. C.E. 66 Damaskos, dr. S. 66 Asikainen, drs. P.J. 67 Dekker, dr. J. den 20 Baâdoudi, MSc. F. 20 Dekker, drs. H. 21 Baaij, drs. A. 20 Delwel, drs. S. 67 Baart, drs. J.A. 66 Deng, dr. D.M. 20 Baas, drs. E.M. 67 Derksen, drs. W.D.C. 66 Baggen, drs. J.H.M. 67 Diermen, dr. D.E. van 20 Bai, dds. X. 20 Dijk, drs. S., van 21 Bakker, dr. A.D. 65 Dijk, MSc. I.A., van 21 Bakker, drs. D.R. 103 Disse, drs. M.A. 66 Baravordeh, F. 66 Donders, drs. H.C.M. 21 Bastidas Coral, dds. A.P. 67 Dubois, drs. L. 66 Becking, prof.dr. A.G. 65 Duijster, dr. D. 20 Beerens, drs. M.W. 67 Eekeren, drs. P.J.A. van 66 Bergh, drs. B. van den 67 Eijkman, prof. dr. M.A.J. 19 Berkhout, dr. W.E.R. 66 Eijnatten, MSc. M. van 67 Betti, MSc. B.F. 67 Elkerbout, MSc. T.A. 21 Bikker, dr. F.J. 19 Elyassi, MSc. Y. 66 Bizzarro, dr. S. 20 Entezami Rad, drs. N. 66 Bloemena, prof.dr. E. 19 Esposito, dds. S.A. 21 Boer, drs. I.R. de 103 Esterik, MSc. F.A.S. van 67 Boffano, dds. P. 67 Evans, dds. C. 67 Boink, MSc. M.A. 20 Everts, prof.dr. V. 65 Bollen, K. 66 Farhanghi, R. 66 Bolscher, dr. J.G.M. 20 Farré-Guasch, dr. E. 66 Bonifacio, dr. C.C. 20 Fazaeli, MSc. S. 67 Bontkes, dr. H.J. 66 Feilzer, prof.dr. A.J. 65 Bos, dr. A. 66 Fernands, drs. G. 66 Bots- van 't Spijker, drs. P.C. 20 Flügge, dds. T.V. 66 Bots, dr. C.P. 20 Forouzanfar, prof.dr. T. 19, 65 Boutsioukis, dr. C. 20 Fraga, dds. S. 66 Bouwman, drs. W.F. 67 Gambon, dr. D.L. 20 Brand, dr. H.S. 20 Geraets, dr. W.G.M. 66 Brandt, dr. B.W. 20 Geurs, MSc. N.C. 21 Broers, drs. D.L.M. 21 Gibbs, prof.dr. S. 65 Bronckers, dr. A.L.J.J. 65 Gimenez, dds. B. 66 Bruers, prof.dr. J.J.M. 19 Gobel, drs. J. 67 Bruggeman, dr. J. P. 66 Goené, drs. R.J. 66 Bruggenkate, prof.dr. C.M. ten 65 Gorter dr. R.C. 19 Buskermolen, MSc. J.K. 67 Graaf, MSc. N.P.J. de 68 Byraki, drs. A.A. 66 Gregor, dds. L. 68 Campos, dds. F. 66 Grootel, drs. R.J. van 68 Cao, MSc. Y. 67 Gunput, MSc. S.T.G. 21 Castro Morais Machado, G. de 21 Harkel, MSc. B. ten 68

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Name Page Name Page Hassan, dr. B.A. 66 Ligtenberg, dr. A.J.M. 20 Hattem, A.B. 66 Lin, dds. X. 67 Haverman, MSc. T.M. 21 Lindeboom, dr. J.A.H. 20 Heidsieck, drs. D.S.P. 68 Liu, dds. H. 20 Heijden, prof.dr.G. J.M.G. van der 19 Liu, dds. Y. 67 Helmers, drs. R. 21 Liu, dr. Y. 65 Hemmatian, dds. H. 68 Lobbezoo, prof.dr. F. 65 Hermus, R.R. 66 Loon, dr. J.J.W.A. van 67 Hertog, drs. D. 21 Loos, prof.dr. B.G. 19 Hesse, dr. D. 20 Lourenco, dds. A.L.R. 68 Ho, MSc. J.P.T.F. 21 Louropoulou, dds. A. 21 Hoekema, dr. A. 65 Loveren, prof.dr. C. van 19 Hol, drs. M.L.F. 21 Maarse, MSc. F. 67 Hoogeveen, MSc. R.C. 66 Maningky, drs. M.S. 68 Houtem, drs. C.M.H.H. van 21 Maskrey, MD. N. 20 Houwing, drs. M. 68 Matse, drs. J.H. 21 Hummel, drs. G.I. 21 May, MSc. A. 21 Imangaliyev MSc. S. 21 Meijer, drs. B.A. 67 Iskender, S.Y. 66 Mevissen-Renckens, drs. E.H.M. 21 Jager, dr. D.H.J. 66 Milbradt Dutra, dds. D.A. 67 Jager, dr.ir. N., de 66 Milheiro, dr. A. 68 Jalali, dds. R. 68 Milstein, dr. D.M.J. 20 Jansen, dr. D.C. 68 Mirahmadi, MSc. F. 68 Janus, ir. M.M. 21 Moghimi, drs. M. 21 Jong, MSc. B.G. de 21 Moinzadeh, dds. A.T. 21 Jong, MSc. T. de 68 Mokhtari-Jafari, dds. F. 68 Jongh, prof.dr. A. de 19 Moonen, MSc. C.G.J. 21 Jong-Lenters, drs. M. de 21 Muris, dr. J. 68 Jongsma, dr. L.A. 66 Muzalev, drs. K.S. 68 Kaaij, drs. N.C.W. van der 68 Neelakantan, dds. P. 21 Kapagiannidou, drs. D. 66 Nes, drs. K.A. van 20 Karagozoglu, drs. K.H. 20 Nicu, dr. E.A. 20 Karssemakers, drs. L.H.E. 68 Nikolopoulou, drs. M. 68 Keijser, prof.dr.ir. B.J.F. 19 Nolte, drs. J.W. 68 Klein Nulend, prof.dr. J. 65 Nolte, F.M. 67 Kleverlaan, dr. C.J. 65 Oomens, drs. M.A.E.M. 68 Knibbe, drs. W. 66 Oosterhuis, M. 67 Kok, drs. P. de 66 Osman, dds. R.B. 67 Kommers, MSc. S.C. 68 Özen, dr. B. 20 Koolstra, dr.ir. J.H. 65 Özok, dr. A.R. 20 Koopman, drs. J.E 21 Papantonopoulos, dds. G.H. 21 Koutris, drs. M. 66 Parvaneh, drs. H. 67 Kraaij, MSc. S. 21 Pathak, MSc. J.L. 68 Kramer, dr. G.J.C. 67 Pereira, dds. G. 67 Krikken, drs. J.B. 21 Persoon, MSc. I.F. 21 Krom, dr. B.P. 19 Prahl, dr. C. 66 Kuik, drs. D. 68 Prahl-Andersen, prof.dr. B. 65 Kuitert, dr. R.B. 65 Prodan, MSc. A. 21 Laheij, dr. A.M.G.A. 20 Raber-Durlacher, dr. J.E. 20 Laine, dr. M.L. 19 Rademacher, MSc. W.M.H. 21 Lange prof.dr. J. de 19, 65 Raghav, dds. K 21 Langenbach, dr. G.E.J. 65 Ravesloot, prof.dr. J.H. 65 Liao, dds. Y. 21 Renders, drs. G.A.P. 68

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Name Page Name Page Restrepo Serna, drs. C.C. 68 Uijlenbroek, drs. H.J.J. 67 Reyes Sevilla, drs. M. 67 Vahed, MSc. F. 67 Ridwan, drs. A. 68 Valstar, drs. M.H. 22 Rijkschroeff, MSc. P. 21 Veen, dr.ir. M.H. van der 20 Roeters, prof.dr. F.J.M. 65 Veerbeek, drs. H.J. 22 Roos, drs. C.J.A.M. de 21 Veerman, prof.dr. E.C.I. 19 Roseboom, drs. H.J. 21 Velden, prof.dr. U. van der 19 Rozeboom, drs. A.V.J. 68 Veldhuizen, MSc. R. 68 Rozema, prof.dr. F.R. 19 Velzen, drs. F.J.J. van 68 Ruiter, drs. M.H.T. de 68 Verheij, dr. H.G.C. 66 Ruiz Zapata, dds. A.M. 68 Verhulst, MSc. J.M.L. 22 Ruslin, dds. M. 68 Verlinden, drs. C.R.A. 68 Salentijn, drs. E. 68 Verrips, prof.dr. G.H.W. 19 Sälzer, dr. S.A. 21 Vervoorn, dr. J.M. 103 Sanderink, dr. G.C.H. 65 Visscher, dr. C.M. 66 Scheerman, MSc. J.F.M. 21 Visscher, dr. J.G.A.M. de 20 Scholtanus, drs. J.D. 68 Vliet, drs. N.I. van 22 Schreuder, drs. W.H. 21 Vogels, drs. M.P.J.M. 22 Schulten, prof.dr. E.A.J.M. 19, 65 Volgenant, drs. C.M.C. 22 Selms, dr. M.K.A. van 66 Vorselen, MSc. D. 68 Serrano Petrillo, dds. C.M. 103 Voskuilen, MSc. L. 22 Shang, MSc. L. 21, 68 Vries, dr. T.J. de 20 Shemesh, dr. H. 20 Vries, MSc. M.W. de 22, 68 Sijbrandij, MSc. T. 21 Vries, prof.dr. N. de 65 Sleen, drs. J.C. van der 68 Waal, drs. S.V. van der 22 Slot, dr. D.E. 20, 67 Waal, prof.dr. I. van der 19 Sluijs, MSc. E. van der 21 Wang, dds. D. 68 Smeele, prof.dr. L.E. 19 Weijden, prof.dr. G.A. van der 19 Soet, dr. J.J. de 19 Weijenberg, dr. R.A.F. 67 Sprangers, MSC. S.L. 68 Wesselink, prof.dr. P.R. 103 Steegman, drs. J. 21 Wetselaar, drs. P. 67 Steenbergen, dr. T.J.M. van 20 Wijk, dr. A.J. van 20 Steenen, drs. S.A. 21 Willems, dr. N.M.B.K. 67 Stelt, prof.dr. P.F. van der 65 Wismeijer, prof.dr. D. 65 Strijp, dr. A.J.P. van 20 Wolff, dr. J.E.H. 67 Su, dds. N. 22 Wouden, drs. P. van der 22 Sun, dds. W. 22 Wu, dr. G. 66 Tabeian, MSc. H. 68 Zamani, dds. Y. 69 Tahmaseb, dr. A. 65, 66 Zande, MSc. M.M. van der 22, 69 Tan, drs. C.W.X. 22 Zandieh Doulabi, dr.ing. B. 67 Tastepe, dds. C.S. 68 Zaura, dr. E. 20 Täubock, drs. T.T.K.J. 68 Zecha, drs. J.A.E.M. 22 Teeuw, MSc. W.J. 22 Zembic, dds. A. 67 Teng, dds. F. 68 Zemouri, MSc. C. 22 Thymi, drs. M. 68 Zentner, prof.dr. A. 65 Tuijt, drs. M. 68 Zhang, dds. X. 69 Tuinzing, prof.dr. D.B. 65 Zygogiannis, dds. K. 67 Tuk, drs. J.C. 22, 68

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