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NSABB June-July 2005 Meeting Agenda
First Meeting of the National Science Advisory Board for Biosecurity June 30 – July 1, 2005 Hyatt Regency Bethesda 7400 Wisconsin Ave. Bethesda, Maryland, 20814 USA Hotel Phone: 301-657-1234 Agenda Webcast: To watch the live webcast of the meeting, click here. The webcast can only be viewed when the meeting is in session at 8:00am-6:00pm on June 30 and at 8:00am-1:30pm on July 1 Eastern Time. You will need RealOne Player to view the webcast. If you do not already have RealOne Player on your computer, download here. Presentation slides: To access the following PowerPoint presentations, click on the presentation titles below. June 30, 2005 Opening Remarks and Swearing in Ceremony Elias Zerhouni, M.D. Director of the National Institutes of Health (NIH) Chair's Remarks and Agenda Overview Dennis L. Kasper, M.D. NSABB Chair Harvard Medical School Introduction of NSABB Members NSABB Structure and Operations Thomas Holohan, M.D. NSABB Executive Director, NIH Office of Biotechnology Activities Break Perspectives on Biosecurity in the Life Sciences NSABB Voting Members Impetus for NSABB: Enhancing Biosecurity on the Life Sciences Rajeev Venkayya, M.D. Special Assistant to the President, Senior Director for Biological and Chemical Defense White House Homeland Security Council Perspectives on Biosecurity in the Life Sciences NSABB Ex Officio Members Lunch Session I- The Development of Criteria for Identifying Dual Use Research and Research Results Introduction: Issues of Relevance to Criteria Development Arturo Casadevall, M.D., Ph.D. Professor of Medicine and of Microbiology & Immunology and Chief of Infectious Diseases Albert Einstein College of Medicine National Research Council Perspective: Experiments of Concern Ron Atlas, Ph.D. -
Copyrighted Material
The Composition of Matter 1 “Everything existing in the universe is the fruit of chance and necessity.” —Democritus 1.1 EARLY DESCRIPTIONS OF MATTER Chemistry has been defined as the study of matter and its interconversions. Thus, ina sense, chemistry is a study of the physical world in which we live. But how much do we really know about the fundamental structure of matter and its relationship to the larger macroscopic world? I have in my rock collection, which I have had since I was a boy, a sample of the mineral cinnabar, which is several centimeters across and weighs about 10 g. Cinnabar is a reddish granular solid with a density about eight times that of water and the chemical composition mercuric sulfide. Now suppose that some primal instinct suddenly overcame me and I were inclined to demolish this precious talisman from my childhood. I could take a hammer to it and smash it into a billion little pieces. Choosing the smallest of these chunks, I could further disintegrate the material in a mortar and pestle, grinding it into ever finer and finer grains until Iwas left with nothing but a red powder (in fact, this powder is known as vermilion and has been used as a red pigment in artwork dating back to the fourteenth century). Having satisfied my destructive tendencies, I would nonetheless still have exactly the same material that I started with—that is, it would have precisely the same chemical and physical properties as the original. I might therefore wonder to myself if there is some inherent limitation as to how finely I can divide the substance or if this is simply limited by the tools at my disposal. -
Twenty Five Hundred Years of Small Science What’S Next?
Twenty Five Hundred Years of Small Science What’s Next? Lloyd Whitman Assistant Director for Nanotechnology White House Office of Science and Technology Policy Workshop on Integrated Nanosystems for Atomically Precise Manufacturing Berkeley, CA, August 5, 2015 Democritus (ca. 460 – 370 BC) Everything is composed of “atoms” Atomos (ἄτομος): that which can not be cut www.phil-fak.uni- duesseldorf.de/philo/galerie/antike/ demokrit.html Quantum Mechanics (1920s) Max Planck 1918* Albert Einstein 1921 Niels Bohr 1922 Louis de Broglie 1929 Max Born 1954 Paul Dirac 1933 On the Theory of Quanta Louis-Victor de Broglie Werner Heisenberg 1932 Wolfgang Pauli 1945 Erwin Schrödinger 1933 *Nobel Prizes in Physics https://tel.archives-ouvertes.fr/tel- 00006807 Ernst Ruska (1906 – 1988) Electron Microscopy Magnifying higher than the light microscope - 1933 Nobel Prize in Physics 1986 www.nobelprize.org/nobel_prizes/physics/laureates /1986/ruska-lecture.pdf Richard Feynman (1918-1988) There's Plenty of Room at the Bottom, An Invitation to Enter a New Field of Physics What would happen if we could arrange the atoms one by one the way we want them…? December 29, 1959 richard-feynman.net Heinrich Rohrer (1933 – 2013) Gerd Binnig Atomic resolution Scanning Tunneling Microscopy - 1981 1983 I could not stop looking at the images. It was like entering a new world. Gerd Binnig, Nobel lecture Binnig, et al., PRL 50, 120 (1983) Nobel Prize in Physics 1986 C60: Buckminsterfullerene Kroto, Heath, O‘Brien, Curl and September 1985 Smalley - 1985 …a remarkably stable cluster consisting of 60 carbon atoms…a truncated icosahedron. Nature 318, 162 (1985) http://www.acs.org/content/acs/en/education/whatis chemistry/landmarks/fullerenes.html Nobel Prize in Chemistry 1996 Curl, Kroto, and Smalley Positioning Single Atoms with a Scanning Tunnelling Microscope Eigler and Schweizer - 1990 …fabricate rudimentary structures of our own design, atom by atom. -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
Date: To: September 22, 1 997 Mr Ian Johnston©
22-SEP-1997 16:36 NOBELSTIFTELSEN 4& 8 6603847 SID 01 NOBELSTIFTELSEN The Nobel Foundation TELEFAX Date: September 22, 1 997 To: Mr Ian Johnston© Company: Executive Office of the Secretary-General Fax no: 0091-2129633511 From: The Nobel Foundation Total number of pages: olO MESSAGE DearMrJohnstone, With reference to your fax and to our telephone conversation, I am enclosing the address list of all Nobel Prize laureates. Yours sincerely, Ingr BergstrSm Mailing address: Bos StU S-102 45 Stockholm. Sweden Strat itddrtSMi Suircfatan 14 Teleptelrtts: (-MB S) 663 » 20 Fsuc (*-«>!) «W Jg 47 22-SEP-1997 16:36 NOBELSTIFTELSEN 46 B S603847 SID 02 22-SEP-1997 16:35 NOBELSTIFTELSEN 46 8 6603847 SID 03 Professor Willis E, Lamb Jr Prof. Aleksandre M. Prokhorov Dr. Leo EsaJki 848 North Norris Avenue Russian Academy of Sciences University of Tsukuba TUCSON, AZ 857 19 Leninskii Prospect 14 Tsukuba USA MSOCOWV71 Ibaraki Ru s s I a 305 Japan 59* c>io Dr. Tsung Dao Lee Professor Hans A. Bethe Professor Antony Hewlsh Department of Physics Cornell University Cavendish Laboratory Columbia University ITHACA, NY 14853 University of Cambridge 538 West I20th Street USA CAMBRIDGE CB3 OHE NEW YORK, NY 10027 England USA S96 014 S ' Dr. Chen Ning Yang Professor Murray Gell-Mann ^ Professor Aage Bohr The Institute for Department of Physics Niels Bohr Institutet Theoretical Physics California Institute of Technology Blegdamsvej 17 State University of New York PASADENA, CA91125 DK-2100 KOPENHAMN 0 STONY BROOK, NY 11794 USA D anni ark USA 595 600 613 Professor Owen Chamberlain Professor Louis Neel ' Professor Ben Mottelson 6068 Margarldo Drive Membre de rinstitute Nordita OAKLAND, CA 946 IS 15 Rue Marcel-Allegot Blegdamsvej 17 USA F-92190 MEUDON-BELLEVUE DK-2100 KOPENHAMN 0 Frankrike D an m ar k 599 615 Professor Donald A. -
A Review of J. Craig Venter's a Life Decoded
A peer-reviewed electronic journal published by the Institute for Ethics and Emerging Technologies ISSN 1541-0099 17(1) – March 2008 A review of J. Craig Venter’s A Life Decoded Randy Mayes, Duke University Journal of Evolution and Technology - Vol. 17 Issue 1 – March 2008 - pgs 71-72 http://jetpress.org/v17/mayes.htm In the early 1980s, a number of researchers suggested sequencing and mapping the human genome to help the science community better understand diseases and evolution. Following the announcement that the human genome had been sequenced, scientists wrote in peer-reviewed journals that we are not as hardwired as was once believed, and that the sequencing of the genome was just the beginning. Today, researchers have a new set of goals. In popular journalism, however, the science was lost in the shuffle. The media focused more on the dynamics of the conflicting philosophies of the private and public projects. This emphasis is also clear in the titles of several books chronicling the Human Genome Project, all appearing prior to the recent release of Craig Venter’s autobiography, A Life Decoded: My Genome: My Life (2007). Readers will find that Robert Cook-Deegan’s The Gene Wars (1995) and The Common Thread by Sir John Sulston and Georgina Ferry (2002), both written by insiders, are biased towards the philosophy of the public project, a commons approach. Sulston is a socialist who grows runner beans and drives a second hand car. By contrast, Venter travels in Lear jets and conducts business from his yacht. Three other books are more objective. -
The Story of the Invention of the Scanning Tunnelling Microscope (STM)
ANNALS OF SCIENCE, Vol. 65, No. 1, January 2008, 101Á125 Searching for Asses, Finding a Kingdom: The Story of the Invention of the Scanning Tunnelling Microscope (STM) GALINA GRANEK and GIORA HON Department of Philosophy, University of Haifa, Haifa 31905, Israel. Email: [email protected]; [email protected] Received 25 October 2006. Revised paper accepted 17 May 2007 Summary We offer a novel historical-philosophical framework for discussing experimental practice which we call ‘Generating Experimental Knowledge’. It combines three different perspectives: experimental systems, concept formation, and the pivotal role of error. We then present an historical account of the invention of the Scanning Tunnelling Microscope (STM), or Raster-Tunnelmikroskop,and interpret it within the proposed framework. We show that at the outset of the STM project, Binnig and Rohrer*the inventors of the machine*filed two patent disclosures; the first is dated 22 December 1978 (Switzerland), and the second, two years later, 12 September 1980 (US). By studying closely these patent disclosures, the attempts to realize them, and the subsequent development of the machine, we present, within the framework of generating experimental knowledge, a new account of the invention of the STM. While the realization of the STM was still a long way off, the patent disclosures served as blueprints, marking the changes that had to be introduced on the way from the initial idea to its realization. Contents 1. Introduction: accounts of the invention of STM ..................102 2. A novel methodological framework: ‘Generating Experimental Knowledge’ . .........................................104 3. A new account: the three phases .............................106 3.1 Phase one: the blueprint*patent disclosures of STM. -
Humankind 2.0: the Technologies of the Future 6. Biotech
Humankind 2.0: The Technologies of the Future 6. Biotech Piero Scaruffi, 2017 See http://www.scaruffi.com/singular/human20.html for the full text of this discussion A brief History of Biotech 1953: Discovery of the structure of the DNA 2 A brief History of Biotech 1969: Jon Beckwith isolates a gene 1973: Stanley Cohen and Herbert Boyer create the first recombinant DNA organism 1974: Waclaw Szybalski coins the term "synthetic biology” 1975: Paul Berg organizes the Asilomar conference on recombinant DNA 3 A brief History of Biotech 1976: Genentech is founded 1977: Fred Sanger invents a method for rapid DNA sequencing and publishes the first full DNA genome of a living being Janet Rossant creates a chimera combining two mice species 1980: Genentech’s IPO, first biotech IPO 4 A brief History of Biotech 1982: The first biotech drug, Humulin, is approved for sale (Eli Lilly + Genentech) 1983: Kary Mullis invents the polymerase chain reaction (PCR) for copying genes 1986: Leroy Hood invents a way to automate gene sequencing 1986: Mario Capecchi performs gene editing on a mouse 1990: William French Anderson’s gene therapy 1990: First baby born via PGD (Alan Handyside’s lab) 5 A brief History of Biotech 1994: FlavrSavr Tomato 1994: Maria Jasin’s homing endonucleases for genome editing 1996: Srinivasan Chandrasegaran’s ZFN method for genome editing 1996: Ian Wilmut clones the first mammal, the sheep Dolly 1997: Dennis Lo detects fetal DNA in the mother’s blood 2000: George Davey Smith introduces Mendelian randomization 6 A brief History of Biotech -
On Jim Watson's APOE Status: Genetic Information Is Hard to Hide
European Journal of Human Genetics (2009) 17, 147–150 & 2009 Macmillan Publishers Limited All rights reserved 1018-4813/09 $32.00 www.nature.com/ejhg LETTERS 15.6 (95% CI, 10.9–22.5) and 4.3 (95% CI, 3.3–5.5) for APOE e4 homozygotes and e4/e3 heterozygotes respectively, 6 On Jim Watson’s APOE compared to e3 homozygotes. The meta-analytic odds ratios in population-based Caucasian samples were 11.8 status: genetic (95% CI, 7.0–19.8) and 2.8 (95% CI, 2.3–3.5), respec- tively.6 In a large Rotterdam (Netherlands), population- information is hard to based prospective study of people aged 55 years or above, it hide was estimated that 17% of the overall risk of AD could be attributed to the e4 allele, with 3% (95% CI, 0–6%) of cases attributed to the e4/e4 genotype, and 14% (95% CI, 7–21%) European Journal of Human Genetics (2009) 17, 147–149; 7 to the e4/e3 genotype. doi:10.1038/ejhg.2008.198; published online 22 October 2008 A recent investigation of LD for 50 SNPs in and surrounding APOE in 550 Caucasians identified multiple SNPs in the TOMM40 gene B15 kb upstream of APOE, and The recent publication and release to public databases of at least one SNP in the other surrounding genes LU, PVRL2, Dr James Watson’s sequenced genome,1 with the exception APOC1, APOC4 and CLPTM1 were associated with LOAD of all gene information about apolipoprotein E (ApoE), risk.8 In particular, the C allele of SNP rs157581 in provides a pertinent example of the challenges concerning TOMM40 is in strong LD (r240.6) with the C allele of privacy and the complexities of informed consent in the rs429358 in APOE, which defines the e4 allele. -
Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1
bioRxiv preprint doi: https://doi.org/10.1101/483826; this version posted November 30, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1. Industrial Fellow, Manchester Institute of Innovation Research, Alliance Manchester Business School, Manchester University. 2 Senior Visiting Fellow, Institute for the Advanced Study of Sustainability, United Nations University 3. Information System Services, Lancaster University Abstract This article presents the global patent landscape for synthetic biology as a new and emerging area of science and technology. The aim of the article is to provide an overview of the emergence of synthetic biology in the patent system and to contribute to future research by providing a high quality tagged core dataset with 7,424 first filings and 71,887 family members. This dataset is intended to assist with evidence based exploration of synthetic biology in the patent system and with advancing methods for the analysis of new and emerging areas of science and technology. The starting point for the research is recognition that traditional methods of patent landscape analysis based on key word searches face limitations when addressing new and emerging areas of science and technology. Synthetic biology can be broadly described as involving the design, synthesis and assembly of biological parts, circuits, pathways, cells and genomes. As such synthetic biology can be understood as emerging from a combination of overlaps and convergences between existing fields and disciplines, such as biotechnology, genetic engineering, protein engineering and systems biology. -
BEC) in Alkali Atoms Masatsugu Sei Suzuki Department of Physics, SUNY at Bimghamton (Date: January 24, 2012)
Bose-Einstein condensation (BEC) in alkali atoms Masatsugu Sei Suzuki Department of Physics, SUNY at Bimghamton (Date: January 24, 2012) In 1925 Einstein predicted that at low temperatures particles in a gas could all reside in the same quantum state. This peculiar gaseous state, a Bose–Einstein condensate (BEC), was produced in the laboratory for the first time in 1995, using the powerful laser-cooling methods developed in recent years. These condensates exhibit quantum phenomena on a large scale, and investigating them has become one of the most active areas of research in contemporary physics. _________________________________________________________________________ The first gaseous BEC was generated by Eric Cornell and Carl Wieman in 1995 at the University of Colorado at Boulder NIST-JILA lab, using a gas of Rb atoms cooled to 170 nK. For their achievements Cornell, Wieman, and Wolfgang Ketterle at MIT received the 2001 Nobel Prize in Physics. In November 2010 the first photon BEC was observed. _________________________________________________________________________ Carl Wieman was born in Corvallis, Oregon in the United States and graduated from Corvallis High School. Wieman earned his B.S. in 1973 from MIT and his Ph.D. from Stanford University in 1977; he was also awarded a Doctor of Science, honoris causa from the University of Chicago in 1997. He was awarded the Lorentz Medal in 1998. In 2001, he won the Nobel Prize in Physics, along with Eric Allin Cornell and Wolfgang Ketterle for fundamental studies of the Bose-Einstein condensate. In 2004, he was named United States Professor of the Year among all doctoral and research universities. http://en.wikipedia.org/wiki/Carl_Wieman Eric Allin Cornell (born December 19, 1961) is an American physicist who, along with Carl E. -
Scientists Create Cell Based on Man-Made Genetic Instructions
25-5-2010 Scientists create cell based on man-m… Scientists create cell based on man•made genetic instructions By David Brown Friday, M ay 21, 2010; A03 Scientists reported Thursday that they have created a cell controlled entirely by man•made genetic instructions •• the latest step toward creating life from scratch. The achievement is a landmark in the emerging field of "synthetic biology," which aims to control the behavior of organisms by manipulating their genes. Although the ultimate goal of creating artificial organisms is still far off, the experiment points to a future in which microbes could be manufactured with novel functions, such as the ability to digest pollutants or produce fuels. Some ethicists fear that the strategy could also be used to produce biological weapons and other dangerous life forms. In a paper published online by the journal Science, researchers from the J. Craig Venter Institute described using off•the•shelf chemicals and the DNA sequence of Mycoplasma mycoides's genes to make an artificial copy of the bacterium's genome. The scientists then transplanted that genome into the cell of a different (but closely related) microbe. The donor genome reprogrammed the recipient cell, which went on to replicate and divide. The result was new colonies of Mycoplasma mycoides. "We think these are the first synthetic cells that are self• replicating and whose genetic heritage started in the computer. That changes conceptually how I think about life," said J. Craig Venter, 63, who gained fame a decade ago as the co•sequencer of the human genome. His institute has laboratories and offices in Rockville and San Diego.