Tackling Public Enemy #2: Fighting a Deadly Fungus Screening to Prevent Cryptococcal Deaths
Tackling Public Enemy #2: Fighting a deadly fungus Screening to Prevent Cryptococcal Deaths A common, deadly Weighing up strategies Screening to prevent Case studies and costly disease to prevent deaths deaths in South Africa Global burden of Fighting a deadly fungus HIV-associated cryptococcal meningitis 800,000 720,000 700,000 600,000 A common, deadly Weighing up strategies Screening to prevent Case studies 500,000 and costly disease to prevent deaths deaths in South Africa 400,000 300,000 200,000 120,000 Estimated yearly cases Estimated yearly 100,000 54,400 27,200 7,800 7,800 500 6,500 13,600 100 0 North Latin Caribbean Western North Africa Sub-Saharan Eastern South and East Asia Oceania America America and Central and Middle Africa Europe and Southeast Europe East Central Asia Asia Region ~1 million new cases per year and ~ 625,000 deaths per year Park BJ, et al. AIDS 2009;23:525-30. High burden of cryptococcosis in High, early mortality amongst South Africa adults accessing ART in sub-Saharan Africa Incidence of cryptococcosis (n=17,005*) vs. number of persons on antiretroviral treatment (ART)** by year, Gauteng Province, 2002-2010 Incidence 25 ART 300000 250000 antiretroviral treatment antiretroviral treatment 20 Numberon of persons 200000 15 150000 persons 10 100000 5 Incidence (cases per 100,000 per 100,000 Incidence (cases 50000 0 0 2002: 2003: 2004: 2005: 2006: 2007: 2008: 2009: 2010: n=1,194 n=1,511 n=1,539 n=2,000 n=2,253 n=2,109 n=2,141 n=2,141 n=2,117 Year *Complete surveillance audits were conducted throughout; **ASSA-2003 model Lawn S, et al.
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