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Guide to the Papers

Daniel Hartwig . Libraries.Department of Special Collections and University Archives Stanford, California 1998 Copyright © 2015 The Board of Trustees of the Leland Stanford Junior University. All rights reserved. Note This encoded finding aid is compliant with Stanford EAD Best Practice Guidelines, Version 1.0.

Guide to the Arthur Kornberg SC0359 1 Papers Overview Call Number: SC0359 Creator: Kornberg, Arthur, 1918-2007 Title: Arthur Kornberg papers Dates: 1938-2007 Physical Description: 52 Linear feet and 400 megabytes Language(s): The materials are in English. Repository: Department of Special Collections and University Archives Green Library 557 Escondido Mall Stanford, CA 94305-6064 Email: [email protected] Phone: (650) 725-1022 URL: http://library.stanford.edu/spc Custodial History Gift of Arthur Kornberg, 1989, 2002, 2008. Information about Access Search files and other personnel files are restricted. Ownership & Copyright Property rights reside with the repository. Literary rights reside with the creators of the documents or their heirs. To obtain permission to publish or reproduce, please contact the Public Services Librarian of the Dept. of Special Collections and University Archives. Cite As [Identification of item], Arthur Kornberg Papers, SC0359, Stanford University Archives, Stanford, Calif. National Library of Medicine's Profiles in Biography During a research career spanning more than sixty years, Arthur Kornberg made many outstanding contributions to molecular . He was the first to isolate DNA polymerase, the that assembles DNA from its components, and the first to synthesize DNA in a test tube, which earned him a in 1959. He later became the first to replicate an infective virus DNA in vitro. He was the primary architect and first chairman of the Department of at the Stanford University School of Medicine, which under his guidance became a preeminent center for DNA research, including recombinant DNA research. Starting in the 1980s, Kornberg also played a key role in establishing productive ties between academic science and the biotechnology industry. Kornberg was born in , New York on , 1918, the youngest of Joseph and Lena Kornberg's three children. Emigrants from eastern Europe, the Kornbergs owned a small hardware and home furnishings store. Arthur was "an eager and able student" and was allowed to skip grades several times in primary school. He finished high school at age 15, and entered the in 1933. Despite this precocity, Kornberg doesn't recall having any early passion for science, or interest in the natural world as a youngster. (He collected matchbook covers rather than butterflies.) He did well in his high school and college courses, and briefly considered an academic career in the field. During the Depression years, however, medical school seemed a more promising choice. Kornberg received his MD from the in 1941, expecting to become "an internist with academic connections." Following his internship, he began his World War II military service as a ship's doctor on a U.S. Coast Guard vessel in the Caribbean. Though he often quarreled with the ship's captain, Kornberg expected to remain on sea duty for the duration of the war. Kornberg's career took an unexpected turn when his first medical article was published in 1942. In medical school, Kornberg had conducted a small research study into a disorder (later known as Gilbert syndrome) characterized by excessive bilirubin in the blood and a mild benign jaundice, because he himself had the condition. At the time of publication, senior military medical officers, along with National Institutes of Health (NIH) director Rolla Dyer, were desperately seeking out new information on jaundice, due to an outbreak of jaundice induced by the new yellow fever vaccine. [To learn more about yellow fever vaccine, visit the Wilbur Sawyer Papers on Profiles in Science.] Impressed by Kornberg's study, Dyer arranged his reassignment to a research post in the Nutrition Laboratory at NIH in the fall of 1942. His first project involved tracking down a vitamin deficiency in rats induced by sulfa drugs. Studying the vitamins then

Guide to the Arthur Kornberg SC0359 2 Papers known--many of which are coenzymes--Kornberg became intrigued by the central role of in all living processes, and their immense potential for illuminating the mechanisms of cells. In 1945, desiring to pursue studies of the metabolic enzymes involved in (ATP) production, he received leave to spend a year acquiring further biochemistry training with at , and six months with Carl and at Washington University in St. Louis. It was then, he later recalled, that he began a lifelong love affair with enzymes, the large specialized that catalyze all life processes. Several years before, Kornberg had married the other love of his life, Sylvy Ruth Levy. They had met at the University of Rochester and became better acquainted at NIH, where Sylvy was working at the National Institute. Apart from the six years when their sons Roger, Thomas, and Kenneth were small, Sylvy worked full-time in Kornberg's laboratory throughout their long marriage. The children were often with them there outside of school hours, and two of them, Roger and Thomas, also chose careers in biochemistry. Roger Kornberg went on to receive the 2006 . After Kornberg returned to NIH in 1947, he established an Enzyme Section within the Institute of Arthritis and Metabolic Diseases, and continued research into the enzymes involved in metabolic respiration. During the next several years he became very adept at identifying and purifying enzymes, and discovered those that make several key components of metabolic respiration cycles. Encouraged by his success with these systems, he turned his attention to finding the enzyme that assembles various chemical building blocks into the nucleic acids: DNA and RNA. He began by working out the synthesis process for the individual , units composed of a nitrogenous base (cytosine, adenine, guanine, uracil, or thymine) combined with a sugar (ribose or deoxyribose) and a phosphate group. In 1953, Kornberg moved to St. Louis to head the Microbiology Department at Washington University School of Medicine. There he continued working on the synthesis of individual nucleotides, and by 1954 had found the enzymes needed to make all four of the building blocks for RNA. A colleague at Washington University had meanwhile found the enzyme that makes the thymine nucleotide (which substitutes for the uracil nucleotide in DNA). Now able to make the building blocks, Kornberg and his colleagues began looking for the enzymes that would put them together into RNA or DNA. Kornberg focused on the synthesis of DNA after learning in 1955 that Severo Ochoa and his colleagues at NYU had apparently created a synthetic RNA from adenosine diphosphate (ADP) (the product ultimately turned out to be not RNA, but a chain very like it). Working with extracts of E. coli bacteria and radioisotope tracers, Kornberg found which combinations of the nucleotides and other ingredients resulted in the most rapid synthesis of DNA. By the following year he had found and purified the essential enzyme, DNA polymerase, from E. coli, and was able to synthesize DNA in the lab. The results were published in 1958, and Kornberg received the 1959 Nobel Prize in or Medicine (shared with Severo Ochoa) for this work. Shortly before the Nobel Prizes were announced that year, Kornberg had taken up a new position as chair of the new department of biochemistry at the Stanford University School of Medicine in Palo Alto. Stanford had approached him in 1957, offering the unique opportunity to organize and staff the department from the ground up. Kornberg recruited most of his Washington University faculty and staff, and a number of former postdoctoral fellows for Stanford. Retaining the communal laboratory structure and style that they developed in St. Louis, Stanford's department of biochemistry remained a highly productive, tightly-knit group focused mainly on DNA research. Nearly fifty years later, six of the original faculty--Kornberg, Robert Baldwin, , David Hogness, Dale Kaiser, and Robert Lehman--were still there. In this stimulating environment, Kornberg and his colleagues continued to identify and delineate the workings of various enzymes involved in DNA replication. In 1967 they synthesized a viable virus DNA, an achievement lauded by the press (to Kornberg's dismay) as the "creation of life in a test tube." They subsequently found enzymes responsible for DNA repair and rearrangement, and others responsible for the start and elongation of DNA chains and chromosomes. The enzymes they discovered, which allowed the manipulation of DNA, helped make possible the development of recombinant DNA technology and the engineering of and chromosomes. In 1991, after many decades of research on DNA replication, Kornberg switched his research focus to inorganic polyphosphate (poly P), a phosphate polymer. Poly P is found in every bacterial, plant and animal cell, but its functions were not well understood. long regarded it as a molecular fossil, a remnant from earlier evolutionary stages. Kornberg found a variety of likely functions for poly P that include regulating cell responses to stress, and factors responsible for motility and virulence in some of the major disease microorganisms. In addition to his research and administrative duties, Kornberg also taught graduate, medical, and postdoctoral students. With his own and other Stanford departments so closely involved in the early development of recombinant DNA science, he was long interested in building connections between academic scientists and the emerging biotechnology industry. He was a founding partner of an innovative research institute (DNAX Institute of Molecular and Cellular Biology) in 1980, and served on the advisory boards and councils of many university, governmental, and industrial research institutes.

Guide to the Arthur Kornberg SC0359 3 Papers Kornberg published over three hundred scientific papers during his long career, as well as major monographs on DNA replication, a scientific autobiography, an insider's account of the biotechnology industry, and most recently a children's book, titled Germ Stories, based on stories he told his children and grandchildren over the years. Besides the 1959 Nobel Prize, Kornberg received numerous other honors, including election to the National Academy of Sciences in 1957, election to the Royal Society of in 1970, and the National Medal of Science in 1979. He received many honorary doctorates, and in 1999 the University of Rochester dedicated the new Arthur Kornberg Medical Research Building in his honor. Arthur Kornberg died on October 26, 2007 at the Stanford Hospital, of respiratory failure. He was carrying on his lab research until several days before his death. Scope and Content Collection documents Kornberg's work concerning the synthesis of DNA in the laboratory, as well as the synthetic pathways of nucleotides, and includes correspondence, 1947 to 1982; research lab notebooks, 1947 to 1969 (which include those studies for which he received the Nobel Prize in Chemistry in 1959); coursework, lectures, and seminars; Stanford University Departmental records; records concerning professional organizations; and reprints, glass research slides, and audiotapes. Arrangement note The materials are arrenged in eight series: 1. Correspondence; 2. Research and Laboratory Notebooks; 3. Lectures and Seminars; 4. Professional Files; 5. Class Materials; 6. Stanford Administrative and Departmental Records; 7. Personal and Miscellaneous Papers; 8. Audiovisual materia; and two additions. Access Terms Stanford University. School of Medicine. Dept. of Biochemistry--Faculty. DNA--Synthesis. Nobel Prize winners Nobel prize--Stanford faculty--biochemistry

Series 1 Correspondence 1947-1987

Stanford Correspondence, 1957-1975 Box 31, Folder 8 Stanford Correspondence 1957 Box 31, Folder 7 Stanford Correspondence 1958 Box 31, Folder 9 Stanford Correspondence, Jul-Dec 1958 Box 31, Folder 3 Stanford Correspondence A-Co, 1961 Box 31, Folder 4 Stanford Correspondence Co-Me, 1961 Box 31, Folder 5 Stanford Correspondence Me-R, 1961 Box 31, Folder 6 Stanford Correspondence Sa-Y, 1961 Box 31, Folder 15 Stanford Correspondence 1961-1966 Box 26, Folder 13 Stanford Correspondence 1967-1968 Box 28, Folder 8 Stanford Correspondence 1969-1972 Box 30, Folder 2-4 Stanford Correspondence: Medical Search Committee 1972-1975 Box 30, Folder 8 Library Correspondence 1958-1964 Box 31, Folder 14 Library Correspondence 1960-1961 General Correspondence, 1947-1987 Box 15, Correspondence 1947-1951 Folder 11-18 Box 16, Folder 1-2 Correspondence 1951-1952 Box 24, Folder 1 Correspondence 1953 Box 25, Folder 5 Correspondence 1953 Box 24, Folder 2 Correspondence 1954 Box 24, Folder 3 Correspondence 1955 Box 24, Folder 4 Correspondence 1956 Box 24, Folder 5 Correspondence 1957 Box 24, Folder 6 Correspondence 1958 Box 25, Folder 1 Correspondence 1959

Guide to the Arthur Kornberg SC0359 4 Papers Series 1Correspondence 1947-1987

Box 23, Folder 10 Correspondence 1959 Box 29, Folder 1 Correspondence A-K, 1959 Box 29, Folder 2 Correspondence L-Z, 1959 Box 25, Folder 2 Correspondence A-F, 1960 Box 25, Folder 3 Correspondence G-N, 1960 Box 25, Folder 4 Correspondence O-Z, 1960 Box 32, Folder 1 Correspondence 1962 Box 32, Folder 2 Correspondence 1963 Box 32, Folder 3 Correspondence 1964 Box 32, Folder 4 Correspondence A-L, 1965 Box 32, Folder 5 Correspondence M-Z, 1965 Box 32, Folder 9 Correspondence A-J, 1966 Box 26, Folder 1 Correspondence K-Z, 1966 Box 26, Folder 2 Correspondence A-L, 1967 Box 26, Folder 3 Correspondence M-Z, 1967 Box 26, Folder 14 Correspondence A-C, 1968 Box 26, Folder 15 Correspondence D-K, 1968 Box 26, Folder 16 Correspondence L-R, 1968 Box 26, Folder 17 Correspondence S-Z, 1968 Box 27, Folder 1 Correspondence A-B, 1969 Box 27, Folder 2 Correspondence C-D, 1969 Box 27, Folder 3 Correspondence E-K, 1969 Box 27, Folder 4 Correspondence L-P, 1969 Box 27, Folder 5 Correspondence R-Z, 1969 Box 29, Folder 8 Correspondence 1970 Box 27, Folder 6 Correspondence A-E, 1970 Box 27, Folder 7 Correspondence F-J, 1970 Box 27, Folder 8 Correspondence K-O, 1970 Box 27, Folder 9 Correspondence P-Z, 1970 Box 28, Folder 1 Correspondence A-F, 1971 Box 28, Folder 2 Correspondence G-H, 1971 Box 28, Folder 3 Correspondence I-M, 1971 Box 28, Folder 4 Correspondence N-Z, 1971 Box 28, Folder 9 Correspondence A-F, 1972 Box 29, Folder 3 Correspondence G-M, 1972 Box 28, Folder 10 Correspondence N-Z, 1972 Box 29, Folder 4 Correspondence A-F, 1973 Box 29, Folder 5 Correspondence G-M, 1973 Box 29, Folder 6 Correspondence N-Z, 1973 Box 12, Folder 5 Correspondence A-F, 1974 Box 12, Folder 6 Correspondence G-P, 1974 Box 12, Folder 7 Correspondence Q-Z, 1974 Box 12, Folder 8 Correspondence A-H, 1975 Box 12, Folder 9 Correspondence I-R, 1975 Box 13, Folder 1 Correspondence S-Z, 1975 Box 13, Folder 2 Correspondence A-B, 1976 Box 13, Folder 3 Correspondence C-I, 1976 Box 13, Folder 4 Correspondence J-Q, 1976 Box 13, Folder 5 Correspondence R-Z, 1976 Box 13, Folder 6 Correspondence A-G, 1977 Box 11, Folder 1 Correspondence F-K, 1977 Box 11, Folder 2 Correspondence L-Q, 1977 Box 11, Folder 3 Correspondence R-XYZ, 1977 Box 11, Folder 4 Correspondence A-E, 1978 Box 11, Folder 5 Correspondence F-K, 1978 Box 11, Folder 6 Correspondence L-Q, 1978 Box 11, Folder 7 Correspondence R-Z, 1978 Box 11, Folder 8 Correspondence A-H, 1979

Guide to the Arthur Kornberg SC0359 5 Papers Series 1Correspondence 1947-1987

Box 11, Folder 9 Correspondence I-Z, 1979 Box 12, Folder 1 Correspondence A-C, 1980-1981 Box 12, Folder 2 Correspondence D-I, 1980-1981 Box 12, Folder 3 Correspondence J-P, 1980-1981 Box 12, Folder 4 Correspondence Q-S, 1980-1981 Box 6, Folder 4 Correspondence T-Z, 1980-1981 Box 6, Folder 5 Correspondence A-G, 1982 Box 6, Folder 6 Correspondence H-Q, 1982 Box 6, Folder 7 Correspondence R-Z, 1982 Box 6, Folder 8 Correspondence A-E, 1983-1984 Box 6, Folder 9 Correspondence F-J, 1983-1984 Box 7, Folder 1 Correspondence K-R, 1983-1984 Box 7, Folder 2 Correspondence S-Z, 1983-1984 Box 7, Folder 3 Correspondence A-G, 1985-1986 Box 7, Folder 4 Correspondence H-N, 1985-1986 Box 7, Folder 5 Correspondence O-Z, 1985-1986 Box 10, Folder 1 Correspondence A-D, 1987 Box 10, Folder 2 Correspondence E-M, 1987 Box 10, Folder 3 Correspondence N-Z, 1987 Box 2, Folder 14 Benno C. Schmidt, correspondence and papers, 1974-82 Box 18, Folder 13 Bellagio Study and Conference Center, correspondence, 1975 Box 26, Folder 10 American Professors for Peace in the Middle East, Correspondence, 1967-1969 Box 26, Folder 11 Student Reports, DNA, Correspondence, 1961-1969 Box 26, Folder 12 Whiting file, Correspondence, 1964-1965 Box 26, Folder 4-8 Special Subjects Correspondence, 1967 Box 26, Folder 9 Journal of Biological Chemistry, Correspondence with, 1953-1962 Box 28, Folder 5 Japan, April 1971 Box 28, Folder 6 Germany/Israel Trip, Oct-Nov 1971 Box 28, Folder 7 Irvine, 1971 Oct Box 29, Folder 7 Guggenheim Foundation, 1968-1972 Box 30, Folder 1 Correspondence, Prism magazine, Genetic disease and the Support of Science 1973, Box 30, Folder 11 Academic Press, correspondence re: publication of manuscript, included, "Bacterial DNA Polymerases," 1973 Box 31, Folder 10 Correspondence, Cranks, 1959 Box 31, Folder 11 Correspondence re: Nobel Lecture, 1959-1960 Box 31, Folder 12 Correspondence, Sweden, 1959-1960 Box 31, Folder 13 Correspondence, Political, 1961-1964 Box 32, Folder 6 Correspondence re: remodeling, 1965-1966 Box 32, Folder 7 Correspondence MA General Hospital Advisor's Committee, 1965-1966 Box 32, Folder 8 ASBC President, Correspondence, 1965-1966 Series 2 Research and Laboratory Notebooks 1938-1970

Box 7, Folder 6 Pricer Methods Box 7, Folder 7 Ion Exchange [Dataleaflets/Graphs] Box 7, Folder 8 Spectra [Research Notes] Box 15, Medical student notes, 1938-41 Folder 1-10 Box 16, Folder 9 Lab Notebooks: Berkley Brookhaven Boulder 1951; 1955; 1958 Box 16, Folder 10 Lab Notebooks: Pacific Grove 1953 Box 16, Lab Notebooks: SK 1953-[1957] Folder 11-17 Box 17, Folder 1 Lab Notebooks: SK Polymerase I & II, 1958; 1958-1959 Box 17, Folder 2 Lab Notebooks: Johnson Polymerase 1961 Dec-1962 Apr Box 17, Folder 3 Lab Notebooks: SK 1978 Box 17, Folder 4-5 Lab Notebooks: New Enzyme Center: Enzyme Preparations and Box 17, Folder 6 Lab Notebooks: PRPP Book 1 [Vancouver], Jan-Feb 1957

Guide to the Arthur Kornberg SC0359 6 Papers Series 2 Research and Laboratory Notebooks 1938-1970

Box 17, Folder 7 Lab Notebooks: PRPP Book 2 [Vancouver II], Feb 7-Feb 16, 1957 Box 19, Folder Lab Notebooks: NYU (v. 1-17) 1947-1951 Box 20, Folder Lab Notebooks: NYU (v. 18-21) 1951-1953 Box 20, Folder Lab Notebooks: (v. 22-33) 1954-1958 Box 21, Folder Lab Notebooks: (v. 34-49) 1958-1967 Box 22, Folder Lab Notebooks: (v. 51-65) 1963-1969 Box 23, Folder 1 Lab Notebooks: (v. 66-67) 1969 Box 17, Folder 8 Lab Notebooks: Radding 1959-1961 Box 17, Folder 9 Lab Notebooks: Zimmerman 1958-1961 Box 17, Folder 10 Lab Notebooks: Aposnian 1959-1962 Box 17, Folder 11 Lab Notebooks: Frautner Box 17, Folder 12 Lab Notebooks: Swartz 1960-1961 Box 23, Folder 2 Lab Notebooks: Bertsch Em 1969-1970 Box 23, Folder 3 Lab Notebooks: Atkinson 1968 Box 23, Folder 4 Lab Notebooks: Cozzarelli 1968 Box 23, Folder 5 Lab Notebooks: Wehrli, Jackson, Albettson (1962 and 1964) Box 23, Folder 6 Lab Notebooks: Okazaki 1962-1963 Box 23, Folder 7 Lab Notebooks: Okazaki undated Box 23, Folder 8 Lab Notebooks: Nussbaum 1961-1963 Box 23, Folder 9 Lab Notebooks: Reichard/Levy/Richardson undated Series 3 Lectures and Seminars 1949-1987

Box 1, Lectures 1966-1973 Folder 21-32 Box 2, Folder 3-9 Lectures 1974-1977 Box 3, Lectures (off campus) 1972-1974 Folder 16-43 Box 4 Lectures (off campus) 1975-1981 Box 9, Folder 1-56 Lectures/Symposia 1982-1987 Box 7, Folder 9 Seminars 1949 Box 7, Folder 10 Seminars 1950 Box 7, Folder 11 Seminars 1951 Box 8, Folder 1 Seminars 1952-1954 Box 8, Folder 2 Seminars 1955-1958 Box 8, Folder 3 Seminars 1959-1960 Box 30, Folder 6 Seminars correspondence 1970-1971, Box 30, Folder 7 Seminars correspondence 1972-1976, Box 17, Folder 13 Seminars 1980 Box 17, Folder 14 Seminars 1981 Box 17, Folder 15 Seminars 1982 Box 16, Folder 8 Talks 1948-1957 Box 18, Talks 1959-1980 Folder 1-11 Box 30, Folder 5 Talks 1971 Box 16, Folder 6 Lipkins course, 1954 Box 16, Folder 7 St. Louis microbiology lectures, 1956 Box 18, Folder 12 Enzyme substrate complex (seminar) Box 18, Series of speaking engagements 1960s-1970s Folder 14-35 Series 4 Professional Files 1947-1987

Box 1, Folder 5-6 Papers submitted for publication, 1967 Box 2, Folder 1-2 Correspondence re: publishing book [DNA Synthesis], 1972-79 Box 2, Folder 10 Book reviews Box 2, Folder 11 Weizmann Institute, 1971-1980 Box 2, Senate and House Hearings, 1968-1973 Folder 12-13

Guide to the Arthur Kornberg SC0359 7 Papers Series 4 Professional Files 1947-1987

Box 2, Research support 1972-1977 Folder 15-19 Box 3, Folder 1 Research support, 1978-83 Box 3, Folder 2 Genetic Engineering 1976 Box 3, Folder 4 Genetic Engineering 1978 Box 3, Folder 3 Genetic Engineering 1977 Box 3, Folder 5 Senator Kennedy letter [re biomedical research and federal funding], 1978 Box 3, Folder 9 Weizmann Leadership Conference, Los Angeles, June 1981 Box 3, Folder 10 California Medical Association, Anaheim meeting, 1981 Box 3, Folder 11 Aspen Institute for Humanistic Studies - Biomedical Workshop 1981 Box 3, Folder 12 ARK Symposium March 1982 Box 3, Folder 13 National Science Foundation Research Proposal (Membranes in DNA Replications and the Viral Life Cycle) 1978 Box 3, Folder 15 Aging Grant (DNA Transactions and Aging) 1980-83 Box 9, Grants: NSF, NIH 1978-1983, 1982-1987 Folder 57-60 Box 10, Professional organizations, misc. files Folder 4-20 Box 13, Reports, lectures, trips, plans, preparations, 1953-67 Folder 7-26 Box 15, Miscellaneous research files Folder 19-22 Box 16, Folder 5 Publications, 1947-52 Box 25, Folder 7 Wiesmeyer, Herbert, "The Characterization of the Maltose Permease and Amylomaltose of E. Coli,"Ph.D. Thesis Washington University 1959, Box 26, Folder 18 National Academy of Sciences, 1968-1969 Box 29, Folder 10 California State Board of Education-Evolution vs. Creation 1972 Box 29, Folder 11 National Academy of Sciences Box 29, Folder 12 National Academy of Sciences Editorial Board 1966 Box 29, Folder 13 National Academy of Sciences Editorial Board 1965 Box 29, Folder 14 New England Enzyme Center, NIH Panels, reviews, etc. Box 30, Folder 12 Notebook of Kornberg's reports "Enzymatic Synthesis of DNA" Series 5 Class Materials 1953-1968

Box 8, Folder 4 Micro-Biology Syllabus 1953 Box 8, Folder 5 Micro-Biology Syllabus 1955 Box 8, Folder 6 Micro-Biology Syllabus 1956 Box 8, Folder 7 Micro-Biology Syllabus 1957 Box 8, Folder 8 Micro-Biology Syllabus 1958 Box 8, Folder 9 Biochemistry 101-102, 1959-1960 Box 8, Folder 10 Biochemistry 101-102, 1961 Box 8, Folder 11 Biochemistry 101-102, 1962 Box 31, Folder 1 Biochemistry 101-102 (examinations and review questions), 1960-1964 Box 14, Folder 1-4 Biochemistry 101-102, 1963-1968 Box 1, Folder 7 Biochemistry 103, 1966 Box 1, Folder 8 Biochemistry 103, 1968 Box 1, Folder 9 General chemistry workshop, 1968 Box 1, Folder 10 Biology 10-113, 1968 Series 6 Stanford Administrative and Departmental Records 1961-1986

Box 3, Folder 6 Industrial Affiliates Program (Bio Chemistry Dept.), 1980-84 Box 3, Folder 8 Anniversary Scientific Symposia, 1980 Box 3, Folder 14 Roof Project: expansion of biochemistry building, 1980 Box 25, Folder 6 Executive Committee minutes, 1961-62 Box 29, Folder 9 Budget Cuts 1973 Box 1, Folder 1-4 Biochemistry dept. minutes 1966-1970 Box 5 Biochemistry dept. records (faculty minutes), 1971-1983 Box 6, Folder 1-3 Biochemistry dept. records (faculty minutes), 1984-1986

Guide to the Arthur Kornberg SC0359 8 Papers Series 6Stanford Administrative and Departmental Records 1961-1986

Box 30, Folder 9 Binder re Department Responsibilities, 1969-71 Box 30, Folder 10 Executive Committee: minutes, agenda, reports, 1969 Box 1, Folder 11 Student unrest, 1968-69 Box 1, Folder 12 Student unrest, 1969 Box 1, Stanford administrative files, 1968-71 Folder 13-20 Series 7 Personal and Miscellaneous Papers 1947-1979

Box 14, Newspaper clippings, 1967 Folder 5-11 Box 23, Folder 11 Newspaper clippings, publicity, 1979 Box 16, Folder 3 Insurance, 1947-52 Box 16, Folder 4 Personal, 1947-52 Box 33, Folder 1-7 Miscellaneous papers Series 8 Audiovisual Materials 1971 and undated

Box 34-35 Slides: illustrations for lectures Box 36 36.1 Kornberg, Arthur: Membrane structure 1971 Feb 22 Physical Description: 1 audiocassette(s)

Box 36 36.2 Roseman, T.J.: Membrane function in permeation 23-Feb-71 Physical Description: 1 audiocassette(s)

Box 36 36.3-36.5 Kornberg, Arthur: Cell envelopes Feb 24-26, 1971 Physical Description: 3 audiocassette(s)

Box 36 36.6-36.7 Bloch: Steroid structure and synthesis 1971 Mar 2-3 Physical Description: 2 audiocassette(s)

Box 36 36.8 Kornberg, Arthur: Opening address, Cold Spring Harbor 1978 Physical Description: 1 audiocassette(s)

Accession ARCH-2008-108 Additional Material Access Information Partially restricted.

Box 1 Others' work: Abir-Am-Cori Box 2 Others' work: Cozzarelli-Heppel Box 3 Others' work: Herschlag-Klenow Box 4 Others' work: Kline-Loeb Box 5 Others' work: Lohman-Okinawa Box 6 Others' work: Orgel-Thackray Box 7 Others' work: Thomas-Zuckerman Box 8 Poly P-files related to Box 8 Acmetobacter [Acinetobacter?]-other organisms Box 9 Poly P-files Box 9 Pavlov-XLL Box 9 Seminars 1983-1988 Box 10 Seminars 1989-1996 Jan. Box 11 Seminars 1996 July-1999 Dec. Box 11 Correspondence, Germ Stories 2007 Box 12 DNAX: Staffing-Eugenics 1984 Box 13 Grant files (?) 007581 Revision 2005 Box 13 Wednesday club Box 13 Reviews Box 13 Patent-Liposome Box 14 Clinician lecture

Guide to the Arthur Kornberg SC0359 9 Papers Accession ARCH-2008-108Additional Material

Box 14 Course files (including some slides)-Biochem 202 May 1980 Box 14 General Files-Spyros-A; department files; course Box 14 Alphabetical through Ishige 2003 Box 15 Alphabetical: Kuroda-Z Box 15 Science & Society-Hargittai Box 15 DNAX 93-Schening-Plough Box 16 Alpha sequence: Affymetrix-Zyomyx Box 17 Presentations Jan. 2002-Jan. 2005 Box 17 Dean Search File 1964 [CONFIDENTIAL] Box 17 JBC MSS 1957-58 Box 17 Jardetsky appointment [CONFIDENTIAL] Box 17 Slides/illustrations- A Rep Box 18 Presentations Jan. 2000-2001 Box 18 Nucleotic lecture Box 18 [box not full] Box 19 Department 1991 [folder with minutes, memos, financial statements, etc.] Box 19 Department 1992 [folder with minutes, memos, financial statements, etc.] Box 19 Binder: book reviews of Kornberg's Golden Helix Box 19 Bound volume: Collected reprints 1941-1954 Box 19 Bound volume: Reprints 1953-57 Dept. of Microbiology Washington University [Kornberg and other authors] Box 19 Bound volume: Reprints 1958-59 Dept. of Microbiology Washington University & 1959-60 Stanford University [Kornberg and other authors] Box 19 Bound volume: Reprints of the Section on Enzymes and , National Institute of Arthritis and Metabolic Diseases, NIH, 1948-52 Box 19 Binder: slides of text, graphs, charts, and specimens 1973-75 and undated Box 20 Biochemistry 294 Winter 1992 Box 20 Department 1990 [folder with minutes, memos, financial statements, etc.] Box 20 Table 2 Students trained by each faculty member [covers training period of the 1960s-1980s] Box 20 Germ Stories [poems] Box 20 Slides of text, graphs, charts, and specimens-5 binders and one stack Box 20 Tube containing award certificate from city of Osaka, Japan (with English translation) 2004 Box 21 Reprints Box 22 Reprints Box 23 Correspondence, chronological Box 24 Correspondence, chronological Box 25 Correspondence, chronological Box 26 Correspondence, chronological Box 27 Correspondence, chronological Box 28 Correspondence, chronological Box 29 Correspondence, chronological Box 30 Correspondence, chronological Accession ARCH-2002-186 Additional Material

Box 1 Correspondence file re book DNA Sequencing 1973-76 Box 1 Letters of recommendation 1980-88 Box 1 Trip files 1996, 1997 Jan.-Mar Box 1 Notes of graduate student James Flynn on biochemistry, mathematics and physics Box 2 Trip files Apr.-Dec. 1997 Box 2 Annual Review Article, 10/22/1998 Box 2 File re several publications 1997-98 Box 2 Transcript of UC-Berkeley oral history with Kornberg (1997) Box 2 Transcripts from Du Pont trial (Du Pont v Cetus regarding patents) 1989-91, v. 1-4 Box 3 Transcripts from Du Pont trial 1991, v. 5-17 Box 3 Additional materials re Du Pont trial, 1989-81 (correspondence, copies of articles, etc.)

Guide to the Arthur Kornberg SC0359 10 Papers Accession ARCH-2002-186Additional Material

Box 4 Transcripts from Du Pont trial 1991, v. 18-21 Box 4 Other transcripts/documents from trial 1990 Box 4 "For the Love of Enzymes," typescript Box 4 "For the Love of Enzymes," correspondence 1989-93 Box 4 "For the Love of Enzymes," letters and reviews 1989-91 Box 4 Khorana, Dr. H. Gobind – correspondence 1955-68 Box 4 Medical school 1938: biochemistry class notes Box 4 "A Kennedy Plan" 12/7/60 [one page re development in Latin America of medical research institutes] Box 4 Photograph and neg of Kornberg portrait Box 4 DNA polymerase mechanism – notes, illustrations, correspondence, articles, 1969-71 Box 4 DNA duplication, DNA polymerase – assorted articles, clippings, 1954-73 Box 4 DNA duplication, DNA polymerase – correspondence, notes, charts, 1955-72 Box 4 Washington University, Dept of Microbiology – exams and miscellany, 1958-60 Box 4 Szilard, Leo, – letter and petition in response to invasion of Cuba 1961 Box 4 Sherberg, Esther, letter, 1958 Box 4 Kornberg – discharge from U.S. Public Health Service 1953 Box 4 Kornberg – press release and c.v., 1959 Box 5 Weizmann Institute – Bay Area Box 5 Weizmann Institute Box 5 Stanford Correspondence 1973-86 Box 5 DNA Replication – update 1981 (correspondence) Box 5 Book – permissions Box 5 DNA Replication – requests for figure permission Box 5 DNA Replication – figure permissions Box 5 Book – DNA Replication Box 5 "For the Love of Enzymes," preliminary work, interviews, comments and communications Box 5 "For the Love of Enzymes," draft Box 5 "For the Love of Enzymes," image (color transparency) Box 5 Berk Foundation Awards Dinners, programs Box 5 Kornberg's diaries (calendars) 1966/67-2001 Box 6 Figure plates for DNA Replication and other publications Box 7 Assorted publications, mostly biographical re Kornberg Box 7 "Scientists' Lounge" with A. Kornberg and Dr. Osamm Hayaishi; unlabelled 1971 Apr 12 Physical Description: 2 audiotape(s) (reel-to-reel)

Box 8 Certificates, programs, calendars featuring Kornberg, galleys of For the Love of Enzymes, and two plaques Box 9 Plaques and framed items Posters Box MC 1. Hearts and Minds The Life and Science of Alejandro Zaffaroni Box MC 2. "Mechanisms of E. Coli DNA Replication" – Basic Sciences Research Coloquia – Stanford University School of Medicine, Oct. 20, 1983 Box MC 3. Buzz Baldwin Symposium, Berkeley, July 30, 1998 Box MC 4. Book jacket (2 copies) for Kornberg's For the Love of Enzymes Box MC 5. Vedua di S. Gimignano [old map reproduction] signed by 21 people "To Arthur Kornberg with affection" Box MC 6. Gene Action – '95 In Appreciation of Charley [Yanofsky], Asilomar, April 1995. (2 copies plus letter and list of attendees) Box MC 7. I. Robert Lehman Symposium Seventieth Year 1994 Box MC 8. The Nobel Prize in Physiology or Medicine 1995. Edward B. Lewis, Christine Nusslein-Volhard, Eric F. Wieschaus. Box MC 9. 1979 Silliman Memorial Lectures by Arthur Kornberg

Guide to the Arthur Kornberg SC0359 11 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

Accession ARCH-2007-322 Profiles in Science images and metadata 2007 Sep 14 Physical Description: 400 megabyte(s) Physical Description: (321 computer files in 4 directories) Scope and Content Note As part of its Profiles in Science project, the National Library of Medicine has collaborated with Stanford University Libraries Department of Special Collections and University Archives to digitize and make available over the World Wide Web a selection of the Arthur Kornberg Papers for use by educators and researchers. This site provides access to the portions of the Arthur Kornberg Papers of Stanford University Libraries Department of Special Collections and University Archives that have been selected for digitization. Individuals interested in conducting research in the Arthur Kornberg Papers are invited to contact Stanford University Libraries Department of Special Collections and University Archives.

WHBBBB [Notes on bile pigments] 6/7/1939 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note For several years in medical school, Kornberg developed an interest in bile pigments and benign jaundice, and conducted a small study on the incidence of Gilbert's disease among medical students. The resulting publication would lead to a research job at the National Institutes of Health in 1942.; Item is handwritten.

WHBBBC Draft memorandum from Arthur Kornberg to Floyd S. Daft regarding fellowship questionnaires circa 1948 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note This memo to his NIH section chief, Floyd Daft, detailed Kornberg's criteria for awarding postdoctoral fellowships.; Item is handwritten.

WHBBBD Letter from Arthur Kornberg to Fritz Lipmann 5/12/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to biochemist Fritz Lipmann, Kornberg provided details about the enzyme he had purified for splitting DPN (diphosphopyridine nucleotide).

WHBBBF Letter from Arthur Kornberg to Alan Mehler 2/21/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note This letter to his friend Alan Mehler discussed the difficulties involved in Kornberg's ongoing studies of metabolic enzymes, and also mentioned the visit of the eminent German biochemist Otto Warburg.

WHBBBG Letter from Arthur Kornberg to Edwin G. Kreb 2/17/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to his friend and prospective colleague Edwin Kreb, Kornberg described the benefits of working at NIH, as well as his feelings about the changes that were occurring there at the time, such as the building of the new Clinical Center.

WHBBBH Letter from Arthur Kornberg to Severo Ochoa 1/24/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to his former mentor Severo Ochoa, Kornberg discussed the various challenges involved with using different yeast cultures as sources for enzymes.

Guide to the Arthur Kornberg SC0359 12 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBBJ Letter from Arthur Kornberg to Severo Ochoa 12/31/1948 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to his former mentor Severo Ochoa, Kornberg asked if Ochoa could return some Zwischenferment (the enzyme glucose-6-phosphate dehydrogenase) Kornberg had sent him, as the most recent batch wasn't proving as useful for their current experiments. He also reported feeling rather discouraged with the slow progress of his work on metabolic coenzymes.

WHBBBK Letter from Arthur Kornberg to Kenneth E. Holt 12/23/1948 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Kornberg and other enzymologists were aided in their work by researchers at the Anheuser-Busch brewery, who provided supplies of "cleaned" yeast for use as enzyme sources, as illustrated by this letter.

WHBBBL Letter from Arthur Kornberg to J. Oliver Lampen 10/15/1948 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Biologists and during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their labs, as there was often no other source. In this letter to J. O. Lampen, a friend from his time at the Cori lab, Kornberg regretted that he had no ready supplies of nicotinamide derivatives to send, and also discussed his current experiments.

WHBBBM Letter from Arthur Kornberg to Carl F. Cori 10/6/1948 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to his former mentor Carl Cori, Kornberg described his recent success with a new enzyme, and some insights about the role of inorganic pyrophosphate in metabolic processes, and asked Cori to review the report he was preparing on this work.

WHBBBN Letter from G. A. LePage to Arthur Kornberg 11/30/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Kornberg had earlier requested information from G. A. LePage about his new method for preparing TPN (triphosphopyridine nucleotide), but the product he made using the method was not satisfactory. In this letter, LePage discussed possible reasons for Kornberg's problems with the process.

WHBBBP Letter from G. A. LePage to Arthur Kornberg 5/10/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Interested in using TPN (triphosphopyridine nucleotide) for his next series of enzyme studies, Kornberg had written to G. A. LePage for information about his new method for preparing TPN. In this response, LePage detailed the equipment and supplies Kornberg's lab would need to make TPN.

WHBBBS Letter from Arthur Kornberg to Alex B. Novikoff 5/23/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter, Kornberg responded to Novikoff's request for information about preparation of Zwischenferment (the enzyme glucose-6-phosphate dehydrogenase) and samples to begin the process.

Guide to the Arthur Kornberg SC0359 13 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBBT Letter from Alex B. Novikoff to Arthur Kornberg 5/8/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter, biochemist Alex Novikoff asked Kornberg for information about preparing Zwischenferment (the enzyme glucose-6-phosphate dehydrogenase) and several other substances needed for the process.

WHBBBV Letter from Arthur Kornberg to Herman M. Kalckar 3/21/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to biochemist Herman Kalckar, Kornberg provided him with information about the NIH research grants process, and also gave him an update on his work on nucleotide synthesis.

WHBBBX Letter from Carl F. Cori to Arthur Kornberg 2/15/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Kornberg's former mentor Carl Cori wrote to suggest another possible interpretation of a reaction involving TPN, and added a postscript saying, "What mysterious creatures enzymes are."

WHBBBY Letter from Arthur Kornberg to Henry A. Lardy 2/6/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to biochemist Henry Lardy, Kornberg shared his recent work on the pathway of uridine triphosphate synthesis, part of the early work that led him to nucleotide synthesis, and ultimately to DNA synthesis.

WHBBBZ Letter from Arthur Kornberg to W. E. Cohn 1/17/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter, Kornberg congratulated biochemist Waldo Cohn on his recent success in isolating single nucleotides from RNA, and discussed his own recent work (closely related to Cohn's) with the nucleotide pyrophosphatase derived from potatoes.

WHBBCC Letter from Arthur Kornberg to Robert K. Morton 11/16/1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Robert Morton, an Australian biochemist, had recently found that baker's yeast contained a cytochrome (a involved in electron transfer in cell metabolism) with a DNA component. That DNA proved to have different base ratios than the yeast's nuclear DNA. He had suggested that this DNA could be used in understanding nucleotide sequences, and Kornberg had been working with some samples Morton sent, looking at their ability to prime DNA synthesis with his polymerase. In this letter, he reported some of his findings to Morton.

WHBBCD Letter from Arthur Kornberg to W. E. Cohn 2/24/1950 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their labs, as there was often no other source. In this letter to Waldo Cohn, Kornberg apologized for the quality of a previous sample sent, and provided more specific information about its requirements.

Guide to the Arthur Kornberg SC0359 14 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBCF Letter from Arthur Kornberg to Carl F. and Gerty Cori 9/28/1950 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter to his former mentors, Carl and Gerty Cori, Kornberg thanked them for good wishes regarding his Paul-Lewis Award, and told them of his ongoing lab work, changes at NIH, and the arrival of his third son, Kenneth.

WHBBCG Letter from G. David Novelli to Arthur Kornberg 11/6/1950 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their labs, as there was often no other source. In this letter, biochemist G. David Novelli reported to Kornberg on his experiments with a sample of Kornberg's nucleotide-splitting enzyme.

WHBBCH Letter from Arthur Kornberg to G. David Novelli 11/14/1950 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter, Kornberg responded to biochemist G. David Novelli's letter describing the activity of an enzyme Kornberg had sent him.

WHBBCK Letter from Arthur Kornberg to the editors of the Journal of Biological Chemistry 1/29/1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCL Letter from Arthur Kornberg to John T. Edsall 12/11/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCM Letter from Arthur Kornberg to the editors of the Journal of Biological Chemistry 12/11/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCN Letter from John T. Edsall to Arthur Kornberg 12/27/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCP Letter from Paul Berg to Arthur Kornberg 7/14/1970 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCQ Letter from Leslie E. Orgel to Arthur Kornberg circa Aug 1969 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Includes a note from .; Item is handwritten.

WHBBCR Letter from Arthur Kornberg to Leslie E. Orgel and Francis Crick 8/19/1969 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 15 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBCT Letter from Julius Marmur to Arthur Kornberg 1/28/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCV Letter from I. Robert Lehman to Julius Marmur 2/9/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCW Letter from H. George Mandel to Arthur Kornberg 1/7/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCX Letter from Arthur Kornberg to H. George Mandel 1/11/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCZ Letter from Arthur Kornberg to Andre Lwoff 10/6/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDB Letter from Arthur Kornberg to James O. Eastland 10/7/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDD Letter from Arthur Kornberg to Van R. Potter 7/5/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDF Letter from Robert L. Sinsheimer to Arthur Kornberg 10/6/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDG Letter from William F. Dove to Arthur Kornberg 9/30/1971 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDH Letter from Arthur Kornberg to William F. Dove 10/15/1971 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDJ Letter from William F. Dove to Arthur Kornberg 10/18/1971 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDK Letter from to Arthur Kornberg 3/23/1971 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDL Letter from Arthur Kornberg to Bruce Alberts 8/6/1971 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 16 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBDM Letter from Arthur Kornberg to Paul Englund 12/17/1971 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDN Letter from Arthur Kornberg to Senator Edward M. Kennedy 3/27/1978 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is a photocopy.

WHBBDX Letter from Arthur Kornberg to Paul N. McCloskey, Jr 8/8/1977 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDY Letter from Arthur Kornberg to Donald S. Fredrickson 2/25/1977 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is a photocopy.

WHBBFB Letter from Arthur Kornberg to Henry S. Kaplan 7/16/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFD Letter from Arthur Kornberg to Robert H. Alway 6/18/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFF Letter from Robert H. Alway to Arthur Kornberg 6/13/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFG Letter from Henry S. Kaplan to Arthur Kornberg 6/24/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFH Letter from Arthur Kornberg to Henry S. Kaplan 1/6/1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFK Letter from Arthur Kornberg to 3/14/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFL Letter from Arthur Kornberg to Howard K. Schachman 11/15/1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFM Letter from Arthur Kornberg to Robert L. Sinsheimer 12/14/1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 17 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBFN Letter from Maurice H. F. Wilkins to Arthur Kornberg 8/20/1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten.

WHBBFP Letter from Arthur Kornberg to Maurice H. F. Wilkins 10/11/1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFQ Letter from Arthur Kornberg to Leon A. Heppel 3/9/1955 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFR Letter from Arthur Kornberg to John R. Van Wazar 11/4/1955 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFS Letter from Arthur Kornberg to H. Gobind Khorana 1/10/1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFT Letter from Robert H. Alway to Arthur Kornberg 7/1/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFV Letter from Arthur Kornberg to Frederick E. Terman 2/6/1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGB [Telegram invitation to a White House meeting with Lyndon Johnson] 9/30/1964 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGC Letter from Arthur Kornberg to James A. Shannon 3/11/1968 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is a photocopy.

WHBBGD Letter from Robert Baldwin to Arthur Kornberg 5/20/1959 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGF Letter from Arthur Kornberg to Robert Baldwin 5/27/1959 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGG [Biochemistry 101 exam] 1960-1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 18 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBGH [Biochemistry 101 exam] 1961-1962 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGJ Letter from Arthur Kornberg to H. Gobind Khorana 2/28/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGK Letter from Arthur Kornberg to H. Gobind Khorana 3/8/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGL Letter from H. Gobind Khorana to Arthur Kornberg 3/18/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten.

WHBBGP Letter from Arthur Kornberg to Robert K. Morton 10/29/1962 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Robert Morton, an Australian biochemist, had recently found that baker's yeast contained a cytochrome (a protein involved in electron transfer in cell metabolism) with a DNA component. That DNA proved to have different base ratios than the yeast's nuclear DNA. He had suggested that this DNA could be used in understanding nucleotide sequences, and Kornberg had been working with some samples Morton sent, looking at their ability to prime DNA synthesis with his polymerase. In this letter, Kornberg apologized for letting other projects delay his work on the Morton DNA.

WHBBGR Letter from Muriel Beadle to Arthur Kornberg 1/26/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In 1966, geneticist and Nobel laureate and his wife Muriel published a laymen's guide to genetics titled "The Language of Life: An Introduction to the Science of Genetics." In this 1965 letter, Muriel Beadle asked Kornberg to clarify some details of his DNA synthesis work to include in the book.

WHBBGS Letter from Arthur Kornberg to Muriel Beadle 2/4/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In 1966, geneticist and Nobel laureate George Beadle and his wife Muriel published a laymen's guide to genetics titled "The Language of Life: An Introduction to the Science of Genetics." In this 1965 letter, Kornberg responded to Muriel Beadle's request for details of his DNA synthesis work to include in the book.

WHBBGT Letter from Muriel Beadle to Arthur Kornberg 2/14/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In 1966, geneticist and Nobel laureate George Beadle and his wife Muriel published a laymen's guide to genetics titled "The Language of Life: An Introduction to the Science of Genetics." In an earlier letter, Muriel Beadle had asked Kornberg to clarify some details of his DNA synthesis work to include in the book. In this letter, she attached a chapter draft incorporating his response.; Item is handwritten.

Guide to the Arthur Kornberg SC0359 19 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBGV [Chapter 19, p. 219] circa Feb 1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Muriel Beadle sent Kornberg this manuscript insert for Chapter 19 of "The Language of Life: An Introduction to the Science of Genetics," after incorporating some details on his DNA synthesis work. Co-authored by geneticist George Beadle, the book was published in 1966.

WHBBGW Letter from Arthur Kornberg to D. S. Fahrney 1/14/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Like many acclaimed scientists, Kornberg was keenly aware that scientific merit was not the sole basis for awards and other honors. He made this clear when asked to recommend others for awards, as in this letter regarding Marshall Nirenberg, who would win a Nobel Prize in 1968 for his work on the .

WHBBGY Letter from Arthur Kornberg to Allan Hauck 5/27/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note As a Nobel laureate, Kornberg often received requests for his opinions on philosophical questions. He responded with concise and thoughtful answers, as illustrated by his letter to philosophy professor Allan Hauck.

WHBBGZ Letter from Arthur Kornberg to Robert L. Sinsheimer 7/9/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Working to synthesize a viable DNA, Kornberg turned to the small bacterial viruses M13 and Phi X174. Biophysicist Robert Sinsheimer at the California Institute of Technology had found that the single-stranded, circular Phi X174 virus DNA was converted to a double helix after entering its E. coli host, and the double stranded form was by itself infective. In this letter, Kornberg asked for a sample of Sinsheimer's virus to start investigating its possible use as a replication template. It was from this virus that Kornberg was able to create an infective synthetic viral DNA in 1967.

WHBBHB Letter from Arthur Kornberg to Robert L. Sinsheimer 7/29/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Working to synthesize a viable DNA, Kornberg turned to the small bacterial viruses M13 and Phi X174. Biophysicist Robert Sinsheimer at the California Institute of Technology had found that the single-stranded, circular Phi X174 virus DNA was converted to a double helix after entering its E. coli host, and by itself was infective. In a previous letter, Kornberg had asked for a sample of Sinsheimer's virus to start investigating its possible use as a replication template. This letter reported on his initial results with the virus. It was from this virus that Kornberg was able to create an infective synthetic viral DNA in 1967.

WHBBHC Letter from Arthur Kornberg to Henry M. Sobell 4/22/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In their work with DNA polymerase, Kornberg and his colleagues had found that it could induce a seemingly spontaneous synthesis of an adenine-thymine polymer, without a template. This phenomenon raised a number of questions about the nature of chemical bonds in nucleotides and nucleic acids, and the exact mechanism of the polymerase. In this letter, Kornberg responded to Henry Sobell's research proposal on this topic.

Guide to the Arthur Kornberg SC0359 20 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBHD Letter from Henry M. Sobell to Arthur Kornberg 12/31/1964 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In their work with DNA polymerase, Kornberg and his colleagues had found that it could induce a seemingly spontaneous synthesis of an adenine-thymine polymer, without a template. This phenomenon raised a number of questions about the nature of chemical bonds in nucleotides and nucleic acids, and the exact mechanism of the polymerase. In this letter, Henry Sobell asked Kornberg about the feasibility of approaching some of these problems via crystallographic studies and included his research proposal on this topic.

WHBBHF Letter from Arthur Kornberg to George Streisinger 2/2/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Geneticist George Streisinger was a noted expert on the bacterial virus (phage) T4. In this letter, Kornberg asked him if there might be a mutant strain of T4 suitable for studying DNA synthesis in infected E. coli cells, noting that regular T4 produced so much lysozyme that the host cells were too fragile to harvest.

WHBBHG Letter from George Streisinger to Arthur Kornberg 2/9/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Geneticist George Streisinger was a noted expert on the bacterial virus (phage) T4, and Kornberg had written to ask him if there might be a mutant strain of T4 suitable for studying DNA synthesis in infected E. coli cells. In this letter, Streisinger explained that such a mutant had been isolated and provided detailed instructions for preparing cultures.

WHBBHH The Chemical Basis of Heredity 10/17/1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this lecture given to an audience of non-scientists, Kornberg demonstrated his talent for making complex topics accessible, and provided a look at the state of the art in in 1961.

WHBBHJ [National Cancer Conference presentation (Philadelphia)] 1964-9 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this presentation at the 1964 National Cancer Conference, Kornberg discussed how molecular biology research, though a "poverty pocket" in the academic world, might soon improve our knowledge of how genes function, and how things go wrong in genetic processes.

WHBBHL An Understanding of Life on a Molecular Basis 4-Feb-65 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In 1965, Kornberg participated in a lecture series titled "Science--A Challenge to Man's Faith." His presentation discussed the current state of scientific knowledge about inheritance and evolution, the evolution of scientific thought itself, and the role of science as a guide to behavior. Finally, he reflected on the spiritual aspects of the pursuit of knowledge.

Guide to the Arthur Kornberg SC0359 21 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBHN Basic Motives of a Professional Life 1969-7 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Kornberg was trained as a physician before he found his calling in biochemistry, and remained close to medical schools and medical problems throughout his career. In this article, he reflected on three basic motives of a professional life, as applied to careers in medicine and science.

WHBBHP Ebb Tide in Medical Research 9/22/1970 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note As a researcher who experienced firsthand the immense growth of federal support for scientific research after 1940, Kornberg was troubled by deep research budget cuts during the Nixon administration. As he noted in this essay, scientific research was increasingly important to society, but like anything else, needed advocates to keep the public--and their representatives in government--aware of its value.; Based on remarks made at the Markle Scholars' Meeting.

WHBBHQ Letter from Arthur Kornberg and David S. Hogness to Newton Steward 10/23/1972 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note During the 1960s, the California State Department of Education had been increasingly pressured by religious groups to include Creation Theory in science textbooks used in the public schools. In 1972, Kornberg and his colleague David Hogness asked to address the Department on this matter, and explained why they believed that including Creation Theory would be bad for science education (and would make Californians the "laughing stock of the entire civilized world"). After hearings in 1972, the Department of Education decided not to require Creation Theory in science textbooks or curricula.; Item is a photocopy.

WHBBHR Letter from Arthur Kornberg to Edward Dempsey 10/30/1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBHT Letter from Arthur Kornberg to Salvador E. Luria 3/14/1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBMN Letter from Arthur Kornberg to Avram Goldstein 7/16/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBMP [Lab notebook 33, 1957-1958 (excerpt 1)] 30 August - 18 September 1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMQ [Lab notebook 33, 1957-1958 (excerpt 2)] 20 September - 1 October 1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

Guide to the Arthur Kornberg SC0359 22 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBMR [Lab notebook 28, 1956 (excerpt 1)] 18-20 July 1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMS [Lab notebook 28, 1956 (excerpt 2)] 30-Aug-56 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMT [Lab notebook 28, 1956 (excerpt 3)] 6-7 September 1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMV [Lab notebook 28, 1956 (excerpt 4)] 22-25 September 1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMW [Lab notebook 28, 1956 (excerpt 5)] 19-Sep-56 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMX [Lab notebook 28, 1956 (excerpt 6)] 4-8 October 1956 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten. Item is a photocopy.

WHBBMZ [Lab notes on Morton DNA] 6/13/1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is handwritten.

WHBBBW Letter from W. E. Cohn to Arthur Kornberg 3/15/1951 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Biochemist Waldo Cohn had taught Kornberg the powerful technique of ion exchange chromatography in 1949. In this letter, he responded to Kornberg's recent work on the likely configuration of the nucleotides he was then studying.

WHBBDP Letter from Senator Edward M. Kennedy to Arthur Kornberg 1/31/1978 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDQ [Fact sheet on federal research funding] 19-Jan-78 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Part of a package for participants in Senate hearings on 19 January 1978.

Guide to the Arthur Kornberg SC0359 23 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBDR Issues to be Addressed by Scientists with Government 19-Jan-78 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Part of a package for participants in Senate hearings on 19 January 1978.

WHBBDS Goals of the Scientific Delegation 19-Jan-78 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Part of a package for participants in Senate hearings on 19 January 1978.

WHBBDW Backgrounder on Recombinant DNA Research 7/20/1977 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFJ Letter from Alexander Rich to Arthur Kornberg 3/8/1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBHM Hearings on the Human Impact of Advance in Biological Science [Testimony to Senate Subcommittee on Government Research] 3/8/1968 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note The success of Kornberg and others in creating synthetic copies of DNA and RNA had provoked public concern about the future consequences of genetic engineering, even before recombinant DNA technology was developed in the 1970s. In March 1968, Kornberg and other leading researchers in the field testified before the Senate Subcommittee on Government Research to address these concerns. Kornberg explained the current state of knowledge in molecular biology, the immense potential for medical applications, and the need for much more federal funding for this branch of research.

WHBBHS Letter from to Arthur Kornberg 1/27/1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBBQ Letter from Severo Ochoa to Arthur Kornberg 3/29/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter, Kornberg's former mentor Severo Ochoa thanked him for a sample of TPN (triphosphopyridine nucleotide) and discussed his ongoing work on citrate synthesis.

WHBBBR Letter from Severo Ochoa to Arthur Kornberg 1/3/1949 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In this letter, Kornberg's former mentor Severo Ochoa discussed his current work with biotin and its possible role in metabolism.

WHBBDZ [Map of Stanford University Campus] circa 1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFC [Architect's model of new Stanford Medical Center] 1957 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 24 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBFW [Construction of Edwards Building, Stanford Medical School] circa 1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFX [Construction of hospital wing, Stanford Medical School] circa 1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFY [Construction of Lane Medical Library, Stanford Medical School] circa 1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBFZ [Construction of Clinic Building, Stanford Medical School] circa 1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBGQ Letter from Severo Ochoa to Arthur Kornberg 5/11/1962 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCB Letter from Robert K. Morton to Arthur Kornberg 11/29/1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their labs, as there was often no other source. Here Robert Morton responded to Kornberg's report, sent several weeks earlier.

WHBBCJ Letter from the editors of the Journal of Biological Chemistry to Arthur Kornberg 1/24/1958 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCS Letter from Francis Crick to Arthur Kornberg 5/10/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBCY Letter from Andre Lwoff to Arthur Kornberg 9/27/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDC Letter from Van R. Potter to Arthur Kornberg 5/18/1960 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

WHBBDT DNA Synthesizer Says Fear of Unknown Hurts Research 9/10/1969 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Item is a photocopy.

WHBBDV Creator of DNA Scores Talk of 'Biological Bomb' 1/6/1972 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 25 Papers Accession ARCH-2007-322Profiles in Science images and metadata 2007 Sep 14

WHBBGM Letter from Francis Crick to Arthur Kornberg 10/17/1959 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note Writing to congratulate Kornberg on receiving a Nobel Prize, Francis Crick also provided an update on the current work of his colleagues and John Kendrew. In 1962, Perutz and Kendrew would share the Nobel Prize in Chemistry for their work on the structures of proteins such as and ; Crick would share the Nobel Prize in Medicine or Physiology with and , for the discovery of the structure of DNA.; Item is handwritten.

WHBBGX Letter from Allan Hauck to Arthur Kornberg 4/27/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note As a Nobel laureate, Kornberg often received requests for his opinions on philosophical questions, as illustrated by this letter from philosophy professor Allan Hauck.

WHBBHK Letter from Peter M. Brown to Arthur Kornberg 1/12/1965 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note In 1965, Kornberg participated in a lecture series titled "Science--A Challenge to Man's Faith." His presentation discussed the current state of scientific knowledge about inheritance and evolution, the evolution of scientific thought itself, and the role of science as a guide to behavior. Finally, he reflected on the spiritual aspects of the pursuit of knowledge.

WHBBNB Letter from Robert K. Morton to Arthur Kornberg 7/14/1961 Physical Description: 1 computer file(s) (TIFF) Scope and Content Note

Guide to the Arthur Kornberg SC0359 26 Papers