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Urinary Paraben Concentrations and Ovarian Aging Among Women from a Fertility Center
Urinary Paraben Concentrations and Ovarian Aging among Women from a Fertility Center The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Smith, Kristen W., Irene Souter, Irene Dimitriadis, Shelley Ehrlich, Paige L. Williams, Antonia M. Calafat, and Russ Hauser. 2013. “Urinary Paraben Concentrations and Ovarian Aging among Women from a Fertility Center.” Environmental Health Perspectives 121 (11-12): 1299-1305. doi:10.1289/ehp.1205350. http://dx.doi.org/10.1289/ehp.1205350. Published Version doi:10.1289/ehp.1205350 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879222 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA All EHP content is accessible to individuals with disabilities. A fully accessible (Section 508–compliant) HTML version of this article is available at http://dx.doi.org/10.1289/ehp.1205350. Research Urinary Paraben Concentrations and Ovarian Aging among Women from a Fertility Center Kristen W. Smith,1 Irene Souter,2 Irene Dimitriadis,1,2 Shelley Ehrlich,1 Paige L. Williams,3 Antonia M. Calafat,4 and Russ Hauser1,2 1Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA; 2Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Harvard Medical School/Massachusetts General Hospital Fertility Center, Boston, Massachusetts, USA; 3Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA; 4National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA In 2008, the Cosmetic Ingredient Review BACKGROUND: Parabens are preservatives commonly used in personal care products, pharmaceuticals, Panel concluded that parabens used in cos- and foods. -
Alpha-Fetoprotein: the Major High-Affinity Estrogen Binder in Rat
Proc. Natl. Acad. Sci. USA Vol. 73, No. 5, pp. 1452-1456, May 1976 Biochemistry Alpha-fetoprotein: The major high-affinity estrogen binder in rat uterine cytosols (rat alpha-fetoprotein/estrogen receptors) JOSE URIEL, DANIELLE BOUILLON, CLAUDE AUSSEL, AND MICHELLE DUPIERS Institut de Recherches Scientifiques sur le Cancer, Boite Postale No. 8, 94800 Villejuif, France Communicated by Frangois Jacob, February 3, 1976 ABSTRACT Evidence is presented that alpha-fetoprotein nates in hypotonic solutions, whereas in salt concentrations (AFP), a serum globulin, accounts mainly, if not entirely, for above 0.2 M the 4S complex is by far the major binding enti- the high estrogen-binding properties of uterine cytosols from immature rats. By the use of specific immunoadsorbents to ty. AFP and by competitive assays with unlabeled steroids and The relatively high levels of serum AFP in immature rats pure AFP, it has been demonstrated that in hypotonic cyto- prompted us to explore the contribution of AFP to the estro- sols AFP is present partly as free protein with a sedimenta- gen-binding capacity of uterine homogenates. The results tion coefficient of about 4-5 S and partly in association with obtained with specific anti-AFP immunoadsorbents (12, 13) some intracellular constituent(s) to form an 8S estrogen-bind- provided evidence that at low salt concentrations,'AFP ac-' ing entity. The AFP - 8S transformation results in a loss of antigenic reactivity to antibodies against AFP and a signifi- counts for most of the estrogen-binding capacity associated cant change in binding specificity. This change in binding with the 4-5S macromolecular complex. -
Studies on the Effects of Paraben Mixtures on MCF-7 Breast Cancer
Studies on the Effects of Paraben Mixtures on MCF-7 Breast Cancer Cells in Culture A thesis submitted in partial fulfilment of the requirements for the Degree of Masters of Science in Biochemistry In the Department of Chemistry At the University of Canterbury New Zealand By Kristie Webber University of Canterbury 2013 Table of Contents Acknowledgements .............................................................................................................................. i Abstract ............................................................................................................................................... ii Abbreviations ..................................................................................................................................... iii List of figures and tables .................................................................................................................... iv 1 Introduction ......................................................................................................................................... 1 1.1 Hormones and the endocrine system ........................................................................................... 2 1.2 Estrogens ....................................................................................................................................... 5 1.2.1 What are estrogens? .............................................................................................................. 5 1.2.2 17β-Estradiol ......................................................................................................................... -
Estrone-Compound-Pal-011921
ESTRONE COMPOUND What is this medicine? Estrone (es-trohn) E1 Estrone is a hormone derived from yams and may be given to women who no longer produce a sufficient amount on their own. It may be used to reduce menopause symptoms (e.g., hot flashes, vaginal dryness). It may be used to help prevent bone loss. It may also be used for other conditions as determined by your doctor. Compounded Drug Forms: BLA tablet, sublingual tablet, fast-burst sublingual tablet, vaginal tablet, troche, vaginal suppository, cream, gel What should I tell my health care provider before I take this medicine? Allergy to estrone Pregnant or breastfeeding Have undiagnosed severe vaginal bleeding Active cancer of the breast or uterus A history of blood clots, stroke or heart attacks Smoking while using this medication may increase your risk of blood clots. Have liver dysfunction or disease How should I use this medicine? Follow the package directions provided by Belmar Pharmacy and by your prescriber. Your dosage is based on your medical condition and response to therapy. Follow the dosing schedule provided carefully. Oral tablets may be taken with or without food, if it upsets your stomach take it with a small meal. Sublingual tablets and fast-burst sublingual tablets should be placed under the tongue or between the cheek and gums and held in place until fully dissolved. Avoid swallowing saliva to ensure best absorption into the blood stream. Avoid eating or drinking 15 minutes before or after taking sublingual tablet. Topical products can be applied to the inner arm, upper thigh, back of the knee, tops of the feet and inner wrists. -
Science of the Total Environment 445–446 (2013) 299–305
Science of the Total Environment 445–446 (2013) 299–305 Contents lists available at SciVerse ScienceDirect Science of the Total Environment journal homepage: www.elsevier.com/locate/scitotenv Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007–2008 Erika S. Koeppe, Kelly K. Ferguson, Justin A. Colacino, John D. Meeker ⁎ Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States HIGHLIGHTS ► Triclosan and parabens are widely used in the US and elsewhere. ► Biomarkers of exposure were examined in relation to serum thyroid hormone levels. ► In adults, we observed inverse associations between parabens and thyroid hormones. ► In adolescents, we observed positive associations between triclosan and total T3. ► Future research is necessary to confirm findings and explore clinical relevance. article info abstract Article history: Triclosan and parabens are broad spectrum antimicrobials used in a range of consumer products. In vitro and Received 28 September 2012 animal studies have suggested the potential for these compounds to disrupt thyroid function, though studies Received in revised form 17 December 2012 in humans have been limited. The objective of the study was to assess the relationship of urinary concentra- Accepted 17 December 2012 tions of triclosan and parabens with serum thyroid measures in a large, representative sample of the US pop- Available online 20 January 2013 ulation. We conducted an exploratory, cross-sectional analysis of data on urinary biomarkers of triclosan and paraben exposure and serum thyroid measures obtained from 1831 subjects (ages≥12 years) as part of the Keywords: – Biomarkers 2007 2008 National Health and Nutrition Examination Survey (NHANES). -
Paraben and Breast Cancer: a Stromal Link
University of Tennessee, Knoxville TRACE: Tennessee Research and Creative Exchange Doctoral Dissertations Graduate School 5-2020 Paraben and Breast Cancer: A Stromal Link Emily Hager University of Tennessee, [email protected] Follow this and additional works at: https://trace.tennessee.edu/utk_graddiss Recommended Citation Hager, Emily, "Paraben and Breast Cancer: A Stromal Link. " PhD diss., University of Tennessee, 2020. https://trace.tennessee.edu/utk_graddiss/5915 This Dissertation is brought to you for free and open access by the Graduate School at TRACE: Tennessee Research and Creative Exchange. It has been accepted for inclusion in Doctoral Dissertations by an authorized administrator of TRACE: Tennessee Research and Creative Exchange. For more information, please contact [email protected]. To the Graduate Council: I am submitting herewith a dissertation written by Emily Hager entitled "Paraben and Breast Cancer: A Stromal Link." I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the equirr ements for the degree of Doctor of Philosophy, with a major in Nutritional Sciences. Ling Zhao, Major Professor We have read this dissertation and recommend its acceptance: Jay Whelan, Guoxen Chen, Hwa-Chain Wang Accepted for the Council: Dixie L. Thompson Vice Provost and Dean of the Graduate School (Original signatures are on file with official studentecor r ds.) Paraben and Breast Cancer: A Stromal Link A Dissertation Presented for the Doctor of Philosophy Degree The University of Tennessee, Knoxville Emily Nicole Hager May 2020 ACKNOWLEDGMENTS I am greatly honored and humbled to have pursued my Ph.D. -
VI.2 Elements for a Public Summary
VI.2 Elements for a Public Summary VI.2.1 Overview of disease epidemiology In women in menopausal period, the decrease of hormones (estrogen levels) result in genital areas becoming dry, itchy and more easily irritated. Vaginal atrophy is a frequent complaint of these women. Symptoms associated with vulvovaginal atrophy (VVA), such as lack of lubrication and pain with intercourse, affect 20% to 45% of midlife and older women. About 50% of otherwise healthy women over 60 years of age experience symptoms related to urogenital atrophy such as vaginal dryness, dyspareunia, burning, itching, as well as urinary complaints or infections of the lower urinary tract. As these alterations frequently affect the quality of life of postmenopausal women, it is important for doctors to detect their presence and offer treatment options. VI.2.2 Summary of treatment benefits Estriol normalizes the vaginal, cervical and urethral epithelium and thus helps to restore the normal microflora and the physiological pH in the vagina. Moreover, estriol increases the resistance of the vaginal epithelial cells to infection and inflammation and decreases the incidence of urogenital complaints. Estriol, which is an estrogen, can be used in the treatment of vaginal symptoms and complaints (vaginal dryness, itching, discomfort and painful intercourse) due to estrogen deficiency related to menopause (whether naturally or surgically induced). In a randomized clinical trial versus placebo, intravaginal application of a low dose of estriol (50 micrograms per application) the main endpoint was to evaluate the efficacy of the product by evaluation of the change in the maturation value of the vaginal epithelium after 12 weeks of treatment. -
206679Orig1s000
CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 206679Orig1s000 PHARMACOLOGY REVIEW(S) DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION CENTER FOR DRUG EVALUATION AND RESEARCH PHARMACOLOGY/TOXICOLOGY NDA/BLA REVIEW AND EVALUATION Application number: 206679 Supporting document/s: SDN10, SN0000 Applicant’s letter date: June 22, 2015 CDER stamp date: June 22, 2015 Product: Simvastatin oral suspension Indication: Treatment of primary and homozygous familial hypercholesterolemia in adults and for the treatment of heterozygous familial hypercholesterolemia in adult and pediatric patients (≥10 years) Applicant: Rosemont Pharmaceuticals (a wholly owned subsidiary of Perrigo Pharmaceuticals, U.S. agent) Review Division: Division of Metabolism and Endocrinology Products Reviewer/Team Leader: C. Lee Elmore, PhD Division Director: Jean-Marc Guettier, MD Project Manager: Richard Whitehead Disclaimer Except as specifically identified, all data and information discussed below and necessary for approval of NDA 206679 are owned by Rosemont Pharmaceuticals Ltd. or are data for which Rosemont Pharmaceuticals Ltd. has obtained a written right of reference. Any information or data necessary for approval of NDA 206679 that Rosemont Pharmaceuticals Ltd. does not own or have a written right to reference constitutes one of the following: (1) published literature, or (2) a prior FDA finding of safety or effectiveness for a listed drug, as reflected in the drug’s approved labeling. Any data or information described or referenced below from reviews or publicly available summaries of a previously approved application is for descriptive purposes only and is not relied upon for approval of NDA number 206679. 1 Reference ID: 3906236 NDA 206679 Reviewer/Team Leader: C. -
Estrogen ------Active Ingredient Protective Neurosteroid I.E
Estrogen --------------------------------------------------------------- Active Ingredient protective neurosteroid i.e. neuromodulators, neuroprotective and regulate neurotransmission. • Estrogen (Estrone, Estradiol, Estriol) Before you take estrogen What is in this leaflet When you must NOT take it: This leaflet contains some information about your • If you are allergic to the active ingredient medication. It does not take the place of talking to • If the medication is expired or has not been stored your doctor or pharmacist. All medicines have risks correctly and benefits. Your doctor has weighed the risks of you • If you have or have history of breast cancer or taking this medication against the positive benefits other estrogen-dependent tumour they expect it will have for you. If you have any • If you have a history of venous thromboembolism concerns about taking this medicine, please contact (blood clots in the vein) us again or speak with your doctor or pharmacist for more information. Keep this leaflet with the medicine Let us know if you are: as you may need to read it again in the future. • Pregnant, planning on becoming pregnant, or breastfeeding What it is used for • Suffer from any other medical conditions such as migraine, diabetes, epilepsy This medication contains one or more active • or take any other medications ingredients of estrogens (estrone, estradiol, estriol). Estrogens play important roles in stimulating growth For a full list of precautions, please contact our of the reproductive tissues, maintaining healthy pharmacy bones, increasing the levels of neurotransmitters in the brain, and helping keep the cardiovascular system How to take estrogen healthy. Estrogens relieve symptoms (e.g. -
Analysis of Natural and Synthetic Estrogens at Sub-PPT Levels In
Analysis of Natural and Synthetic Estrogens at Sub-PPT Levels in Surface Water and Crude Influent Water Utilizing the ACQUITY UPLC System with 2D LC Technology and Xevo TQ-S Euan Ross,1 Angela Boag,2 Hamish Todd,2 and Neil Gatward2 1Waters Corporation, France; 2Scottish Water, Organics Lab, Edinburgh GOAL This method has undergone a full validation and was To confirm and quantify the presence of natural found to meet the required performance criteria for and synthetic estrogens in surface and final effluent waters at sub ppt levels. this challenging analysis. BACKGROUND Estrogens are routinely used either as THE SOLUTION contraceptive medicines or in hormone Surface water samples were initially extracted utilizing an optimized method on replacement therapy and can enter aquatic an off-line Oasis® HLB Solid Phase Extraction (SPE) Cartridge. Crude influent environments via the discharge of final effluent and final effluent samples were first filtered, and then underwent the same waters. Estrogens are believed to have a Oasis HLB offline extraction step. This was followed by a second SPE step utilizing negative effect on aquatic environments by Sep-Pak® Silica Cartridges. These off-line SPE steps are critical to achieving lower disrupting the hormonal systems of fish. In limits of detection by providing the initial concentration step and cleaner extracts; the EU directive 2013/39/EU, 15 additional thus reducing ion suppression on the tandem quadrupole mass spectrometer. priority substances were added to the water framework directive (WFD, 2000/60/EC). In this latest update, 17α-ethinylestradiol and 17β-estradiol were not included in this list but 17 -ethinylestradiol, 1.2 ng/L instead added to a watch list in order to gather further data regarding the presence of these compounds in aquatic environments and the 17 -estradiol, 12 ng/L risks they pose. -
Methyl and Propyl Parabens Screening Profile Parabens Are Contaminants That Have Been Found in Potential Drinking Water Sources in Minnesota
CONTAMINANTS OF EMERGING CONCERN PROGRAM Methyl and Propyl Parabens Screening Profile Parabens are contaminants that have been found in potential drinking water sources in Minnesota. The information in this profile was collected for the screening process of the Minnesota Department of Health’s Contaminants of Emerging Concern (CEC) program. The chemicals nominated to the CEC program are screened and ranked based on their toxicity and presence in Minnesota waters. Based on these rankings, some chemicals are selected for a full review. CEC program staff have not selected methyl or propyl paraben for full reviews. Methyl and Propyl Parabens Uses Potential Health Effects Parabens are antimicrobial chemicals used as Parabens are potential endocrine (hormone) preservatives in packaged foods, pharmaceuticals, disruptors, but their estrogen activity is much lower cosmetics, and personal care products. Methyl and than natural estradiol.4 Parabens have been detected propyl parabens are commonly found together in in human breast cancer tissue; however, studies have paraben mixtures used in consumer products. not shown that parabens actually cause breast cancer.4 Much of what is known about endocrine disruption is Parabens in the Environment based on limited studies, which in some cases have Based on a study Minnesota Pollution Control Agency produced conflicting results. These studies may not (MPCA) did in Minnesota in 2010, parabens are represent what might happen when humans ingest widespread in Minnesota’s surface water. Twenty-one methyl or propyl parabens from food or water.4 percent of streams sampled had propyl paraben, with a maximum concentration of 0.6 parts per billion Based on the screening assessment, it is unclear (ppb). -
Northern Saskatchewan Prenatal Biomonitoring Study Technical
Northern Saskatchewan Prenatal Biomonitoring Study Technical Summary Report Ministry of Health, Government of Saskatchewan, 2019 Northern Saskatchewan Prenatal Biomonitoring Study Summary Report Ministry of Health, Government of Saskatchewan, 2019 For more information contact: Environmental Health Population Health Branch Miinistry of Health 3475 Albert Street, Regina, SK, Canada, S4S 6X6 Telephone: 306-787-8847 Website: https://publications.saskatchewan.ca:443/api/v1/products/101374/formats/112048/download TABLE OF CONTENTS Executive Summary ......................................................................................................................................................... 1 Introduction ..................................................................................................................................................................... 4 Study Rationale ......................................................................................................................................................... 4 Biomonitoring as the Tool of Choice ......................................................................................................................... 5 Stakeholder Analysis ................................................................................................................................................. 6 Alberta’s Biomonitoring Program ......................................................................................................................... 6 Engagement with Northern