Pediatric Product Guide

Leading the way in science-based pediatric nutrition products, to help give newborns, infants and toddlers the best start in life. 2 Important Contact Information

MJN Representative ______

Phone Number ______

Healthcare Professional Contact Information 1-800-457-3550 or [email protected] Customer Service – To place an order. 1-812-429-6399 or [email protected] Medical Service – Answers to product questions. hcp.meadjohnson.com Healthcare Professionals – To get product information and more.

Consumer Contact Information

1-800-BABY123 For parents. enfamil.com A friendly source of information for moms.

The information in this handbook is provided as a service to healthcare professionals. Every measure is taken to assure that this is the most current and accurate information available. Because our products are subject to revision, we ask that you please refer to the product label for the most accurate information.

3 4 About Mead Johnson Nutrition Our Mission: To Nourish the World’s Children for the Best Start in Life

ead Johnson, a global leader in infant In February 2017, Reckitt Benckiser, a leading global health and hygiene Mand children’s nutrition, develops, company, agreed to acquire Mead Johnson Nutrition as part of its ambition manufactures, markets and distributes to become the global leader in consumer healthcare. more than 70 products in over 50 markets worldwide. The company’s mission is to Since June 2017, Mead Johnson Nutrition has been operating as the Infant nourish the world’s children for the best Formula and Child Nutrition division of Reckitt Benckiser. Mead Johnson’s start in life. science, innovation, product portfolio and mission—to nourish the world’s children for the best start in life—are vital, foundational elements of The Mead Johnson name has been RB Nutrition. associated with science-based infant and children’s nutrition products for over 100 years. Our founder, Edward Mead Johnson, worked with his family physician to develop a product for his son facing life-threatening feeding difﬁ culties. Today, his quest for better nutrition continues to drive our team to deliver products with an uncompromising commitment to quality and safety. The company’s Enfa® family of brands, including Enfamil® infant formula, is the world’s leading Our Mission franchise in infant and children’s nutrition. To nourish the world’s children for the best start in life.

Trusted by millions of families and healthcare 110+ years of leadership in infant and providers to help infants and children grow child nutrition. and thrive. 6 The Mead Johnson Pediatric Nutrition Institute Pediatric Nutrition is Our Sole Focus

ead Johnson believes that good Mnutrition early in life supports Global Network lifelong health; that’s why our only MJPNI collaborates with purpose at the Mead Johnson Pediatric leading academic and clinical Nutrition Institute (MJPNI) is to institutions to address the advance and apply science that nutritional needs of children. benefi ts children. Our vision is to be a trusted partner in this unique and critical space. Leading Research We have established a strong and MJPNI is committed to growing global network of scientists researching nutrition for and research facilities that allow Mead long-term outcomes. Johnson to make important contributions to the body of knowledge within the fi eld of nutrition. Since 2010, we have dedicated four new MJPNI research and development technology centers around the world—in the U.S., Mexico, China and Singapore. Additionally, the MJPNI is a key collaborator on one of the largest global studies ever conducted to evaluate human milk over the fi rst year of lactation—The Global Exploration Nutrition of Human Milk Study (GEHM). This understanding of human milk composition and functionality is the Education inspiration for the next generation of pediatric nutrition innovation. MJPNI disseminates knowledge that advances the understanding of breakthrough science.

Dedicated to scientiﬁ c discovery to advance pediatric nutrition and drive beneﬁ cial product innovation. 7 Our Legacy: A History of Innovation in Nutrition

Dextri-Maltose, Sobee, the fi rst Nutramigen®, the fi rst Lofenalac, the fi rst ProSobee®, the fi rst Pregestimil®, the fi rst the fi rst clinically milk-free, lactose-free protein hydrolysate commercially available soy protein infant nutritionally complete tested, physician- infant formula that formula clinically proven formula for infants formula—it is also protein hydrolysate recommended infant derived its protein for the management of with phenylketonuria, milk-free, lactose-free formula containing feeding product from soy fl our. colic due to cow’s milk an inborn error of and sucrose-free. MCT oil. in the U.S. allergy. metabolism.

1911 1929 1942 1958 1965 1971

1924 1933 1949 1959 1966 1983

The fi rst standardized Pablum, the fi rst Vi-Sols, the fi rst Enfamil® Enfamil® Enfamil® Human Milk cod liver oil, a pre-cooked, fortifi ed vitamins for babies in infant formula was Premature formula Fortifi er, the fi rst supplemental source cereal for babies. It drop dosage form. introduced. was launched as a additive designed to of vitamins A and D to was often the fi rst nutritionally complete increase the nutrient combat rickets. solid food babies ate. formula for low-birth- content of breast milk weight infants. for premature infants.

All product claims pertain to the United States, unless otherwise noted. Images may not necessarily reﬂ ect product labels at the time of introduction. All product names in this material indicate trademarks used by Mead Johnson & Company in various countries. Some of these trademarks may be discontinued or may be currently owned by other entities.

8 LactoFree, the fi rst Enfamil A.R.™ infant Enfamil® LIPIL® Enfamil PREMIUM® Enfamil® Enspire™, Enfamil NeuroPro™ milk-based, lactose- formula with added with Iron, the fi rst LIPIL®, the fi rst with two components has a fat-protein blend free formula for infants rice starch was infant formula in the formulation with levels previously only in of MFGM and DHA with feeding problems introduced in France U.S. to include DHA of choline close to that breast milk: MFGM previously found only due to lactose and Belgium. and ARA. of breast milk. and lactoferrin. in breast milk*. intolerance.

1993 1995 2002 2005 2016 2018

1994 1996 2004 2010 2017

Enfagrow® Advanced Formula Expecta® LIPIL® Natural Defense® Enfamil PREMIUM® growing up milk for Enfamil, the ﬁ rst DHA supplement for Dual Prebiotics, formulation with children one year and formula with free pregnant and nursing for gut and immune inositol levels similar older was introduced nucleotides added to moms debuted. health in support of to levels found in in Hong Kong. approximate the levels outcomes similar to human breast milk. found in breast milk. breast milk.

* In amounts supported by clinical research.

9 Our Focus: Sustainability for the Industry and Consumer

Sustainable SourcingRecycling/Reuse Environmental Impact

• All palm oil and cocoa sustainably sourced • Return program in retail operations • Ambitious goals for energy, GHG, water and with full traceability • All RB sites zero waste to landfi ll, with waste reduction • Introduced non-GMO products to U.S. goal to include remaining MJN facilities • Carbon and water footprint being market in 2016 • How2Recycle label scheme for U.S. completed for products, including Enfamil® market is in progress • Energy—renewables and effi ciency (i.e., landfi ll gas powering major facilities)

10 11 Table of Contents

Routine Infant Formulas Other Special Needs Formulas Enfamil PREMIUM® Newborn ...... 16 Pregestimil® ...... 98 Enfamil NeuroPro™ Infant ...... 20 Enfaport™ ...... 102 Enfamil PREMIUM® Infant...... 24 Portagen® ...... 106 Enfamil® Infant ...... 28 3232 A ...... 108 Enfamil® Enspire™ ...... 32 Premature Infant Formulas and Products Feeding Solution Formulas Enfamil® Premature 20 Cal ...... 112 Enfamil NeuroPro™ Gentlease® ...... 36 Enfamil® Premature 24 Cal ...... 116 Enfamil PREMIUM® Gentlease® ...... 40 Enfamil® Premature 24 Cal HP ...... 120 Enfamil® Gentlease® ...... 44 Enfamil® Premature 30 Cal ...... 124 Enfamil® Enspire™ Gentlease® ...... 48 Enfamil® Premature Caloric Recipes ...... 128 Enfamil NeuroPro™ Sensitive ...... 52 Enfamil® DHA & ARA Supplement ...... 134 Enfamil PREMIUM™ A2 ...... 56 Enfamil NeuroPro™ EnfaCare® ...... 136 Enfamil® ProSobee® ...... 60 Enfamil® EnfaCare® ...... 140 Enfamil® Reguline® ...... 64 Enfamil® Human Milk Fortifi er Powder ...... 144 Enfamil A.R.™ ...... 68 Enfamil® Liquid Human Milk Fortifi er High Protein ...... 146 Enfamil® Liquid Human Milk Fortifi er Standard Protein ...... 152 Allergy Formulas for Infants and Toddlers Enfamil® Human Milk Fortifi er Acidifi ed Liquid ...... 158 Nutramigen® with Enfl ora™ LGG®* ...... 74 Nutramigen® (Liquids) ...... 78 Oral Electrolyte Solutions Nutramigen® with Enfl ora™ LGG®* Toddler ...... 82 Enfamil® Enfalyte® ...... 164 PurAmino™ ...... 86 PurAmino™ Jr ...... 90 Hospital Feeding Systems PurAmino™ Jr Vanilla ...... 94 Nursette® Bottles ...... 168 Accessories ...... 170 Starter Kits ...... 173 Enfamil® 24 ...... 174 * LGG ® is a registered trademark of Chr. Hansen A/S.

12 Table of Contents 13 ...... 285 ...... 285 ...... 285 ® ® ® ...... 285 ® Newborn ...... Newborn 285 ...... 285 Infant Gentlease Infant ...... 285 Infant Gentlease ...... 285 Sensitive Gentlease ...... 285 ® ® ® ™ ™ ™ ™ ™ 1...... 258 2...... 262 ...... 2 HP 264 ® ® ® Infant ...... 285 Infant Enspire Gentlease Enspire ® ® ® ® 1 ...... 1 272 ...... 2 276 ® ® Enfamil NeuroPro Enfamil Enfamil NeuroPro Enfamil PREMIUM Enfamil PREMIUM Enfamil Powder Enfamil PREMIUM Enfamil NeuroPro Enfamil Enfamil Phenyl-Free WND Information Additional Product Recommended Storage Guidelines for ...... 280 Mead Johnson Nutrition Products Hospital or Institutional Storage Guidelines ...... 283 for Prepared Formula for Times Hang Feeding Tube ...... 283 Mead Johnson Nutrition Products for Preparation of Feedings ...... 284 Mead Johnson Nutrition Products Phenyl-Free Phenyl-Free ...... TYROS 1 266 ...... TYROS 2 270 WND ...... 182 ...... 178 ® Natural Milk Flavor ...... 194 Natural Milk Flavor ® ™ Gentlease ...... 186 Soy Vanilla Flavor ...... Flavor Vanilla 198 ® ® ™ Toddler Next Step Toddler Toddler Transitions Toddler Liquid Multivitamin Supplement ...... Liquid Multivitamin Supplement 206 ...208 Supplement with Iron Liquid Multivitamin Toddler Nutritional Drink ...... 190 Nutritional Drink Toddler Liquid Iron Supplement ...... Liquid Iron Supplement 214 ® ® ™ ™ Liquid Vitamins A, C & D Supplement ...... C & D Supplement A, Vitamins Liquid 212 ™ ® Liquid Vitamin D Supplement ...... 204 D Supplement Vitamin Liquid ® ® Prenatal Vitamin & Mineral Supplement ...... 216 Vitamin & Mineral Supplement Prenatal Toddler Transitions Toddler Next Step Toddler Toddler Transitions Toddler ™ ® ® ® Infant Probiotics Dietary Supplement ...... 220 Infant Probiotics Dietary Supplement ...... Vitamin D & Breastfed Infant Probiotics 222 Poly-Vi-Sol Tri-Vi-Sol Fer-In-Sol D-Vi-Sol Poly-Vi-Sol ® ® ® ® ® ® ®

Enfamom Enfagrow PREMIUM Enfagrow Enfagrow Enfamil Enfamil Enfamil Enfamil

Enfagrow Metabolic Formulas ...... 226BCAD 1 ...... 230BCAD 2 GA ...... 232 ...... 236 HCY 1 ...... 240 HCY 2 LMD ...... 242 ...... 246 OA 1 ...... 250 OA 2 PFD Toddler...... 252 ...... 256 PFD 2

Dietary Supplements Enfamil

Toddler Formulas Toddler Enfagrow PREMIUM Enfagrow NeuroPro Enfamil Enfamil Additional Product Information (cont.) Ready-To-Drink Natural Milk Flavor ...... 291 Enfagrow® Toddler Next Step™ Ready-To-Drink Vanilla Flavor ..... 291 Enfamil PREMIUM™ A2 ...... 285 Enfamil® ProSobee® ...... 285 Single-Serve Powder Packets Enfamil® Reguline® ...... 285 Enfamil NeuroPro™ Infant ...... 292 Nutramigen® with Enfl ora™ LGG®* ...... 286 Enfamil PREMIUM® Infant ...... 292 Nutramigen® with Enfl ora™ LGG®* Toddler ...... 286 Enfamil NeuroPro™ Gentlease® ...... 292 Pregestimil® ...... 286 Enfamil PREMIUM® Gentlease® ...... 292 ™ ® Enfagrow PREMIUM Toddler Transitions ...... 286 Oral Electrolyte ® ® ® Enfagrow Toddler Transitions Gentlease ...... 286 Enfamil® Enfalyte® ...... 292 Enfagrow® Toddler Transitions® Soy ...... 286 Enfagrow PREMIUM™ Toddler Next Step™ Concentrate Natural Milk Flavor ...... 286 13 fl oz Cans ...... 293 Enfagrow® Toddler Next Step™ Vanilla ...... 286 Human Milk Fortifi er Enfamil A.R.™ ...... 286 Enfamil® Human Milk Fortifi er Powder ...... 293 PurAmino™ ...... 287 Enfamil® Liquid Human Milk Fortifi er High Protein ...... 293 PurAmino™ Jr ...... 287 Enfamil® Liquid Human Milk Fortifi er Standard Protein ...... 293 PurAmino™ Jr Vanilla ...... 287 Enfamil® Human Milk Fortifi er Acidifi ed Liquid ...... 294 3232 A ...... 287 ® Dietary Supplements Portagen ...... 288 ™ ™ ® Enfamom Prenatal Vitamin & Mineral Supplement ...... 295 Enfamil NeuroPro EnfaCare ...... 288 Enfamil® Probiotics ...... 295 Metabolic Products ...... 289 Enfamil® Vi-Sol® Family of Vitamins ...... 295 Ready to Use Product Ordering Guide ...... 296 ® 2 & 6 fl oz Nursette Bottles...... 289 Formula Dilution Instructions ...... 302 8 fl oz Bottles ...... 290 Conversion Tables ...... 311 32 fl oz Bottles ...... 290 Caloric Distribution Table ...... 312 ® Enfamil DHA & ARA Supplement ...... 290 Kosher and Halal Products ...... 313 ™ Enfaport ...... 291 Osmolarity and Osmolality Tables ...... 314 Ready to Drink Potential Renal Solute Load Tables ...... 315 Enfagrow NeuroPro™ Toddler Nutritional Drink ...... 291 Product Amino Acid Compositions ...... 316 Enfagrow PREMIUM™ Toddler Next Step™ Metabolic Formula Amino Acid Compositions ...... 320

* LGG ® is a registered trademark of Chr. Hansen A/S. 14 Routine Infant Formulas ° Clinically shown to improve long-term cognitive outcomes through Enfamil 5 years of age1,* ° Shown to improve respiratory health through the fi rst 3 years of life PREMIUM® when infants were fed through 12 months4,* • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) Newborn and PDX (polydextrose) at 4 g/L is designed to: ° Support immune health by promoting the growth of benefi cial bacteria (bifi dobacteria and lactobacilli)5,6 7 Description/Indication ° Promote soft stools similar to those reported for breastfed infants • Proprietary Triple Health Guard® blend of brain-nourishing DHA, an Enfamil PREMIUM Newborn is a 20 Cal/fl oz milk-based, iron-fortifi ed routine exclusive dual prebiotic blend and 30 total nutrients for growth formula for full-term newborns through 3 months. Enfamil PREMIUM Newborn has DHA in amounts clinically demonstrated to foster cognitive development • Easy-to-digest 80:20 whey-to-casein ratio patterned after early through 5 years of age1,*. Enfamil PREMIUM Newborn is patterned after breast milk2,† early breast milk2,† with an 80:20 whey-to-casein ratio and is designed for • Provides 400 IU of vitamin D in just 27 fl oz newborns. Enfamil PREMIUM Newborn meets American Academy of Pediatrics • Inositol at the average amount found in breast milk|| (AAP) recommendations for vitamin D intake by providing 400 IU of vitamin D • Non-GMO¶ in just 27 fl oz—the approximate daily intake of a newborn. Enfamil PREMIUM • Kosher Newborn offers outcomes in 3 key areas: brain development, immune health and growth. * Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. † Based on whey-to-casein ratio 3-5 days after lactation begins. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women3. § Enfamil PREMIUM Newborn has not been shown superior to the leading competitor in Product Features supporting mental, visual and immune system development. The level of DHA in Similac Pro- • DHA at the clinically proven* amount of 0.32% of total fatty acids, the Advance™ is ~0.15% of total fatty acids. same amount as the worldwide breast milk average3,‡, and double the || The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal8. § amount found in the leading competitor’s product : ¶ Ingredients not genetically engineered. Trace amounts of genetically engineered material may be Clinically proven* to support mental, visual and immune system present in the product, such as from manufacturing environments and process sources. For more ° information, visit enfamil.com/nonGMO. development

16 Enfamil PREMIUM® Newborn 1717 oz 9.2 5.1 41 61 77 15.3 77 14.3 220 400 122 122 138 380 No 12.9 300 270 9 1 0.68 1.8 1.22 8 5.4 32 2.8 1.89 43 29 78 53 24 16.2 24 16.2 63 43 320 12 8.1 15 10.1 15 10.1 27 18.3 75 51 108 73 550 (mOsm/100 mL) mg

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, , Lactose-free Osmolarity Osmolality Potential Renal Solute Load Zinc Iron Magnesium Phosphorus Minerals Calcium Inositol Choline Chloride Vitamin C Potassium Sodium Iodine Biotin Manganese Copper Selenium oz 20 Calories/fl 8.5 43.5 48 19.1 for current information. see product label Please to change. are subject values and ingredients Product nutrient 80:20 9 9 6.1 46 2 1.35 10.2 5.3 3.6 27 2.1 1.42 10.7 0.3 0.2 1.53 75 51 380 11.2 7.6 57 16 10.8 82 60 41 310 80 54 410 (5 fl oz)(5 fl (510 Cal) Powder oz) (5 fl (510 Cal) Powder 300 200 1530 133 90 2 780 530 4000 500 340 2600 140 95 710 1000 680 5100 (mOsm/100 Calories) mcg

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(% Calories) , Vitamin K Vitamin E Vitamin D Vitamin A Vitamins/Other Nutrients Vitamins/Other Water Carbohydrate Linoleic acid Pantothenic acid Vitamin B Fat Ribofl Folic acid Niacin Vitamin B Thiamin Potential Renal Solute Load Fat Carbohydrate Whey:Casein Ratio Protein NUTRIENT FACTS Nutrient Density 20 Calories/fl Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, Product Forms vitamin A palmitate, ribofl avin, thiamin hydrochloride, vitamin B6 ® 1 3 12 Enfamil PREMIUM Newborn is available in powder and ready-to-use liquid. hydrochloride, folic acid, vitamin K , vitamin D , biotin, vitamin B , soy For ordering information, please refer to page 299. lecithin, choline chloride, carrageenan, inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

Composition # A type of prebiotic. Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm olein, ** A source of arachidonic acid (ARA). †† A source of docosahexaenoic acid (DHA). coconut, soy and high oleic sunfl ower oils), whey protein concentrate and less than 2%: galactooligosaccharides#, polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, calcium carbonate, calcium phosphate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, sodium chloride, cupric sulfate, manganese sulfate, sodium Potential Allergens selenite, potassium iodide, soy lecithin, vitamin A palmitate, inositol, Enfamil PREMIUM Newborn contains milk and soy. choline chloride, ascorbic acid, niacinamide, calcium pantothenate, ribofl avin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine. Ingredients: Ready To Use (2 fl oz Nursette® bottle): Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils) and less than 2%: galactooligosaccharides#, polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, whey protein concentrate, potassium citrate, calcium phosphate, sodium chloride, calcium chloride, magnesium phosphate, calcium carbonate, ferrous sulfate, sodium citrate, zinc sulfate, cupric sulfate, potassium iodide, manganese sulfate, sodium selenite, mono- and diglycerides,

18 Enfamil PREMIUM® Newborn . 1919 . J Pediatr J Pediatr Gastroenterol Nutr Gastroenterol J Pediatr . 2007; 44:359-364. 2007; . J Pediatr Gastroenterol Nutr J Pediatr staphylococcus in infants: the hygiene hypothesis extended. extended. the hygiene hypothesis staphylococcus in infants: 2016;62:80-86. prebiotics growselected blends of have normally and reported soft stools similar to those for breast-fed infants. 1999;134:11-14. Salminen S, Endo A, Isolauri E, et al. Early gut colonization Early and with lactobacilli et al. Isolauri E, A, Endo S, Salminen with infants fed formula supplemented Term et al. B, Petschow JA, Vanderhoof Ziegler E, le. Data on fi renal solute load in infancy. Renal solute load and potential Ziegler EE. SJ, Fomon 6. 7. 8. 9. Acta . 2010;156:902-906. . J Pediatr GastroenterolJ Pediatr . 2007;85:1457-1464. . J Pediatr Am J Clin Nutr . 2013;98:403-412. . Am J Clin Nutr Am J Clin 1992;81:107-112. . 2012;54:343-352. 2012;54:343-352. . on childhood cognitive outcomes. cognitive outcomes. on childhood concentrations in human breast milk worldwide. concentrations in human breast milk worldwide. Paediatr. manifestations and common respiratory illnesses in children. galacto-oligosaccharides has a bifi dogenic effect in young infants. dogenic effect in young infants. has a bifi galacto-oligosaccharides Nutr Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation LCPUFA effects of Long-term et al. Cheatham CL, Carlson SE, J, Colombo Re-evaluation ratio of the whey protein/casein of human milk. Lönnerdal B. C, Kunz Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, nutrition on incidence of allergicThe impact of early et al. CL, Berseth Khoury JC, Birch EE, Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose andNew prebiotic blend of polydextrose et al. GW, Welling SH, Mitmesser Scalabrin D, 1. References 2. 3. 4. 5. ° Clinically shown to improve long-term cognitive outcomes through Enfamil 5 years of age3,§ Shown to improve respiratory health through the fi rst 3 years of life ™ ° NeuroPro when infants were fed through 12 months4,§ • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) Infant and PDX (polydextrose) at 4 g/L is designed to: ° Support immune health by promoting the growth of benefi cial bacteria (bifi dobacteria and lactobacilli)5,6 7 Description/IndicationDescrription/Ind ° Promote soft stools similar to those reported for breastfed infants • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature Enfamil NeuroProN Infant is a 20 Cal/fl oz milk-based, iron-fortifi ed, routine breast milk8,‡ formula for fo full-term infants 0–12 months. Enfamil NeuroPro Infant has a # fat-protein blend of MFGM and DHA previously found only in breast milk*. • Inositol at the average amount found in breast milk Emerging evidence from a recent clinical study showed MFGM in formula • Non-GMO** supports cognitive development similar to breast milk†. Enfamil NeuroPro • Kosher Infant is patterned after mature breast milk‡. * In amounts supported by clinical research. † As measured by Bayley-III cognitive score at 12 months in a different formula with MFGM added as an ingredient. ‡ Comparison based on whey:casein ratio of typical mature breast milk (15 days to 6 months after birth)8. Product Features § Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA • Infant formula that has MFGM and DHA is clinically shown to be a safe and ARA; studied before the addition of prebiotics. 1 || Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of and well-tolerated source of nutrition total fatty acids) based on an analysis of 65 studies of 2,474 women2. • DHA at the clinically proven§ amount of 0.32% of total fatty acids, the ¶ Enfamil NeuroPro Infant has not been shown superior to the leading competitor in supporting mental, ™ 2,|| visual and immune system development in infants. The level of DHA in Similac Pro-Advance is same amount as the worldwide breast milk average , and double the ~0.15% of total fatty acids. ¶ amount found in the leading competitor’s product : # The global average total inositol amount in mature breast milk over the course of lactation is 9 Clinically proven§ to support mental, visual and immune system 22 mg/100 kcal . ° ** Ingredients not genetically engineered. Trace amounts of genetically engineered material may development be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

20 Enfamil NeuroPro™ Infant 21 oz No 12.5 300 270 10 3 2 15.3 2.8 1.89 14.3 81.81 5.4 1.22 0.68 41 9.2 5.1 43 29 220 78 53 400 24 16.2 122 63 43 320 1224 8.1 16.2 61 122 15 10.1 77 27 18.3 138 15 10.1 77 75 51 380 108 73 550 (mOsm/100 mL) mg

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(% Calories) , Vitamin D Vitamin A Water Vitamins/Other Nutrients Vitamins/Other Linoleic acid Carbohydrate Ribofl Pantothenic acid Folic acid Vitamin B Niacin Fat Vitamin E Vitamin K Thiamin Vitamin B Potential Renal Solute Load Fat Carbohydrate Whey:Casein Ratio Nutrient DensityProtein 20 Calories/fl NUTRIENT FACTS Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS †† 471/100 mL. 100kcal and 70 IU, Vitamin D levels for ready-to-use are: calcium carbonate, calcium phosphate, magnesium phosphate, Product Forms calcium chloride, sodium chloride, ferrous sulfate, zinc sulfate, cupric Enfamil NeuroPro™ Infant is available in powder and ready-to-use liquid. sulfate, manganese sulfate, potassium iodide, sodium selenite, mono- For ordering information, please refer to page 298. and diglycerides, ascorbic acid, sodium ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin D3, vitamin B12, soy lecithin, carrageenan, choline chloride, Composition inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm 5’-monophosphate), taurine, L-carnitine. olein, coconut, soy and high oleic sunfl ower oils), whey protein Ingredients: Ready To Use (32 fl oz bottle##): Water, nonfat milk, concentrate, whey protein-lipid concentrate (milk)‡‡ and less than lactose, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower 2%: galactooligosaccharides§§, polydextrose§§, Mortierella alpina oil||||, oils) and less than 2%: whey protein-lipid concentrate (milk)‡‡, Schizochytrium sp. oil¶¶, calcium carbonate, potassium citrate, potassium §§ §§ |||| chloride, ferrous sulfate, calcium phosphate, sodium chloride, magnesium galactooligosaccharides , polydextrose , Mortierella alpina oil , ¶¶ oxide, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, Schizochytrium sp. oil , whey protein concentrate, potassium citrate, sodium selenite, soy lecithin, inositol, choline chloride, ascorbic acid, calcium carbonate, calcium chloride, magnesium phosphate, sodium niacinamide, calcium pantothenate, vitamin A palmitate, ribofl avin, chloride, calcium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, sodium selenite, potassium iodide, mono- and thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, diglycerides, soy lecithin, ascorbic acid, sodium ascorbate, vitamin E vitamin K1, biotin, vitamin B12, vitamin E acetate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic acid, vitamin K1, L-carnitine. biotin, vitamin B12, carrageenan, choline chloride, inositol, nucleotides (cytidine 5’-monophosphate, adenosine 5’-monophosphate, disodium Ingredients: Ready To Use (2 & 6 fl oz Nursette® bottles): Water, uridine 5’-monophosphate, disodium guanosine 5’-monophosphate), nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high vitamin D3, taurine, L-carnitine. oleic sunfl ower oils) and less than 2%: whey protein-lipid concentrate ‡‡ §§ §§ |||| (milk) , galactooligosaccharides , polydextrose , Mortierella alpina oil , ‡‡ A source of MFGM (milk fat globule membrane). Schizochytrium sp. oil¶¶, whey protein concentrate, potassium citrate, §§ A type of prebiotic. |||| A source of arachidonic acid (ARA). ¶¶ A source of docosahexaenoic acid (DHA). ## Nutrient profi le subject to change.

22 Enfamil NeuroPro™ Infant . 23 . Acta J Pediatr . 2010;156:902-906. . J Pediatr GastroenterolJ Pediatr . 2014;99:860-868. . . 2007;85:1457-1464. . J Pediatr J Pediatr Gastroenterol Nutr Gastroenterol J Pediatr Am J Clin Nutr . 2007;44:359-364. . Am J Clin Nutr . 2013;98:403-412. . Am J Clin Nutr J Pediatr Gastroenterol Nutr Gastroenterol J Pediatr . 1992;81:107-112. . . 2012;54:343-352. 2012;54:343-352. . of age in infants fed a low-energy, low-protein bovine milk fat with formula supplemented of age low-energy, in infants fed a trial. a randomized controlled globule membranes: concentrations in human breast milk worldwide. outcomes. on childhood cognitive manifestations and common respiratory illnesses in children. dogenic effect in young infants. galacto-oligosaccharides has a bifi Nutr the hygiene hypothesis extended. staphylococcus in infants: 2016;62:80-86. selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. Paediatr 1999;134:11-14. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. Renal solute load and potential renal solute load in infancy. Ziegler EE. SJ, Fomon Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth and 12 mo until nutrition, Neurodevelopment, et al. Hernell O, E, Domellöf N, Timby nutrition on incidence of allergicThe impact of early et al. CL, Berseth Khoury JC, Birch EE, Early gut colonization with lactobacilli and et al. Isolauri E, A, Endo Salminen S, Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, supplementation Long-term effects of LCPUFA et al. Cheatham CL, SE, Carlson Colombo J, and prebiotic blend of polydextrose New et al. GW, Welling SH, Mitmesser Scalabrin D, Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with Term et al. B, Petschow JA, Vanderhoof Ziegler E, Re-evaluation of the whey protein/casein ratio of human milk. B. Lönnerdal C, Kunz Data on fi le. Data on fi 1. 4. 6. 2. 3. 5. 7. 8. 9. 10. References

Infant contains milk and soy. contains milk Infant ™

Enfamil NeuroPro Enfamil Potential Allergens Potential

• A Natural Defense® Dual Prebiotic blend of GOS Enfamil (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is designed to: ® PREMIUM ° Support immune health by promoting the growth of benefi cial bacteria (bifi dobacteria and lactobacilli)4,5 Infant 6 ° Promote soft stools similar to those reported for breastfed infants • Proprietary Triple Health Guard® blend of brain-nourishing DHA, an exclusive dual prebiotic blend and 30 total nutrients for growth Description/Indication • Clinically proven growth similar to breastfed infants through 12 months7,† Enfamil PREMIUM Infant is a 20 Cal/fl oz milk-based, iron-fortifi ed, routine • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature formula for full-term infants 0–12 months. Enfamil PREMIUM Infant is breast milk8,* clinically demonstrated to foster cognitive development through 5 years of age1. Enfamil PREMIUM Infant is patterned after mature breast milk* and • Inositol at the average amount found in breast milk|| offers proven clinical outcomes in 3 key areas: brain development, immune • Non-GMO¶ health and growth. • Kosher

* Comparison based on whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth). † Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA Product Features and ARA; studied before the addition of prebiotics. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation • DHA at the clinically proven† amount of 0.32% of total fatty acids, the of total fatty acids) based on an analysis of 65 studies of 2,474 women2. same amount as the worldwide breast milk average2,‡, and double the § Enfamil PREMIUM Infant has not been shown superior to the leading competitor in § supporting mental, visual and immune system development. The level of DHA in Similac amount found in the leading competitor’s product : Pro-Advance™ is ~0.15% of total fatty acids. ° Clinically proven† to support mental, visual and immune system || The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal9. development ¶ Ingredients not genetically engineered. Trace amounts of genetically engineered material may be ° Clinically shown to improve long-term cognitive outcomes through present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO. 5 years of age1,† ° Shown to improve respiratory health through the ﬁ rst 3 years of life when infants were fed through 12 months3,†

24 Enfamil PREMIUM® Infant 25 oz No 12.5 300 270 10 81.81 5.4 1.22 0.68 40 9.1 5 3 2 15.1 2.8 1.89 14.1 43 29 220 78 53 390 24 16.2 121 63 43 320 1224 8.1 16.2 61 121 15 10.1 76 27 18.3 136 15 10.1 76 75 51 380 108 73 550 (mOsm/100 mL) mg

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(% Calories) , Vitamin E Vitamin K Thiamin Vitamin D Vitamin A Water Vitamins/Other Nutrients Vitamins/Other Linoleic acid Carbohydrate Ribofl Pantothenic acid Folic acid Vitamin B Niacin Fat Vitamin B Potential Renal Solute Load Fat Carbohydrate Whey:Casein Ratio Nutrient DensityProtein 20 Calories/fl NUTRIENT FACTS Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS Product Forms sulfate, potassium iodide, sodium selenite, mono- and diglycerides, Enfamil PREMIUM® Infant is available in powder and ready-to-use liquid. ascorbic acid, sodium ascorbate, vitamin E acetate, niacinamide, calcium For ordering information, please refer to page 299. pantothenate, vitamin A palmitate, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin D3, vitamin B12, soy lecithin, carrageenan, choline chloride, inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, Composition L-carnitine. Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm olein, Ingredients: Ready To Use (32 fl oz bottle): Water, nonfat milk, lactose, coconut, soy and high oleic sunfl ower oils), whey protein concentrate vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils) and # # and less than 2%: galactooligosaccharides , polydextrose , Mortierella less than 2%: galactooligosaccharides#, polydextrose#, Mortierella alpina ** †† alpina oil , Crypthecodinium cohnii oil , calcium carbonate, potassium oil**, Crypthecodinium cohnii oil††, whey protein concentrate, potassium citrate, potassium chloride, ferrous sulfate, calcium phosphate, sodium citrate, calcium carbonate, calcium chloride, magnesium phosphate, chloride, magnesium oxide, zinc sulfate, cupric sulfate, manganese sulfate, sodium chloride, calcium phosphate, ferrous sulfate, sodium citrate, zinc potassium iodide, sodium selenite, soy lecithin, inositol, choline chloride, sulfate, cupric sulfate, manganese sulfate, sodium selenite, potassium ascorbic acid, niacinamide, calcium pantothenate, vitamin A palmitate, iodide, mono- and diglycerides, soy lecithin, ascorbic acid, sodium ribofl avin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A 1 12 acid, vitamin K , biotin, vitamin B , vitamin E acetate, nucleotides (cytidine palmitate, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine acid, vitamin K1, biotin, vitamin B12, carrageenan, choline chloride, inositol, 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, nucleotides (cytidine 5’-monophosphate, adenosine 5’-monophosphate, L-carnitine. disodium uridine 5’-monophosphate, disodium guanosine ® Ingredients: Ready To Use (2 & 6 fl oz Nursette bottles, 8 fl oz bottle): 5’-monophosphate), vitamin D3, taurine, L-carnitine. Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils) and less than 2%: galactooligosaccharides#, # A type of prebiotic. polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, whey ** A source of arachidonic acid (ARA). †† A source of docosahexaenoic acid (DHA). protein concentrate, potassium citrate, calcium carbonate, calcium phosphate, magnesium phosphate, calcium chloride, sodium chloride, ferrous sulfate, sodium citrate, zinc sulfate, cupric sulfate, manganese Potential Allergens Enfamil PREMIUM Infant contains milk and soy.

26 Enfamil PREMIUM® Infant . 27 Acta J Pediatr . 2007;44:359-364. . . 2007;42:151-159. . J Pediatr Gastroenterol Nutr J Pediatr Nutr Today . 1992;81:107-112. . selected blends of prebiotics growblends of prebiotics selected and have normally to those reported soft stools similar for breast-fed infants. Health World and Prevention and the Centers for Disease Control Canadian infants using Organization charts. Paediatr 1999;134:11-14. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. in infancy. load and potential renal solute load Renal solute Ziegler EE. SJ, Fomon Re-evaluation protein/casein ratio of the whey milk. of human Lönnerdal B. C, Kunz Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with supplemented infants fed formula Term et al. B, Petschow JA, Vanderhoof E, Ziegler How doing? Growth is baby of US and al. et Maharaj N, Mitmesser SH, PW, Ferguson le. Data on fi 8. 6. 7. 9. 10. . . 2010;156:902-906. . J Pediatr GastroenterolJ Pediatr . 2007;85:1457-1464. . J Pediatr J Pediatr Gastroenterol Nutr J Pediatr Am J Clin Nutr . 2013;98:403-412. . Am J Clin Nutr Am J Clin . 2012;54:343-352. 2012;54:343-352. . concentrations in human breast milk worldwide. concentrations in human breast milk worldwide. on childhood cognitive outcomes. cognitive outcomes. on childhood 2016;62:80-86. staphylococcus in infants: the hygiene hypothesis extended. the hygiene hypothesis extended. staphylococcus in infants: manifestations and common respiratory illnesses in children. dogenic effect in young infants. has a bifi galacto-oligosaccharides Nutr Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation LCPUFA effects of Long-term et al. Cheatham CL, Carlson SE, J, Colombo Salminen S, Endo A, Isolauri E, et al. Early gut colonization lactobacilli and with et al. E, Isolauri A, Endo Salminen S, nutrition on incidence of allergicThe impact of early et al. CL, Berseth Khoury JC, Birch EE, andNew prebiotic blend of polydextrose et al. GW, Welling SH, Mitmesser Scalabrin D, 2. References 1. 5. 3. 4. • A Natural Defense® Dual Prebiotic blend of GOS ® Enfamil (galactooligosaccharides) and PDX (polydextrose), at 4 g/L is Infant designed to: ° Support immune health by promoting the growth of benefi cial bacteria (bifi dobacteria and lactobacilli)4,5 ° Promote soft stools similar to those reported for breastfed infants6 • Clinically proven growth similar to breastfed infants through Description/Indication 12 months7,† Enfamil Infant is a 20 Cal/fl oz milk-based, iron-fortifi ed, routine formula • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature for full-term infants 0–12 months. Enfamil Infant is clinically demonstrated breast milk8,* to foster cognitive development through 5 years of age1. Enfamil Infant is • Kosher patterned after mature breast milk* and offers proven clinical outcomes in 3 key areas: brain development, immune health and growth. * Comparison based on whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth). † Studies compared infants fed Enfamil with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women2. Product Features § Enfamil Infant has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% • DHA at the clinically proven† amount of 0.32% of total fatty acids, the of total fatty acids. same amount as the worldwide breast milk average2,‡, and double the amount found in the leading competitor’s product§: ° Clinically proven† to support mental and visual development ° Clinically shown to improve long-term cognitive outcomes through 5 years of age1,† ° Shown to improve respiratory health through the fi rst 3 years of life when infants were fed through 12 months3,†

28 Enfamil® Infant 29 oz No 12.5 300 270 9 8 5.4 40 1.81 1.22 0.68 9.1 5.1 6 4.1 30 3 2 15.2 2.8 1.89 14.1 43 29 220 78 53 390 63 43 320 1224 8.1 16.2 61 121 15 10.1 76 27 18.3 136 15 10.1 76 75 51 380 108 73 550 (mOsm/100 mL) mg

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|| A type of prebiotic. Composition ¶ A source of arachidonic acid (ARA). Ingredients: Powder: Nonfat milk, lactose, vegetable oil (palm olein, # A source of docosahexaenoic acid (DHA). coconut, soy and high oleic sunfl ower oils), whey protein concentrate and less than 2%: galactooligosaccharides||, polydextrose||, Mortierella ¶ # alpina oil , Crypthecodinium cohnii oil , calcium carbonate, potassium Potential Allergens citrate, ferrous sulfate, potassium chloride, magnesium oxide, sodium chloride, zinc sulfate, cupric sulfate, manganese sulfate, potassium Enfamil Infant contains milk and soy. iodide, sodium selenite, soy lecithin, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, vitamin A palmitate, vitamin B12, vitamin D3, ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, inositol, vitamin E acetate, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine. Ingredients: Concentrate: Water, nonfat milk, lactose, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils) and less than 2%: galactooligosaccharides||, polydextrose||, Mortierella alpina oil¶, Crypthecodinium cohnii oil#, whey protein concentrate, potassium citrate, calcium carbonate, calcium phosphate, magnesium phosphate, calcium chloride, sodium chloride, ferrous sulfate, sodium citrate, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, mono- and diglycerides, ascorbic acid, sodium ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride,

30 Enfamil

References 1. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation 6. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364. 2. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid ® Infant concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 7. Ferguson PW, Mitmesser SH, Maharaj N, et al. How is baby doing? Growth of US and 3. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic Canadian infants using the Centers for Disease Control and Prevention and World Health manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906. Organization charts. Nutr Today. 2007;42:151-159. 4. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and 8. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta galacto-oligosaccharides has a biﬁ dogenic effect in young infants. J Pediatr Gastroenterol Paediatr. 1992;81:107-112. Nutr. 2012;54:343-352. 9. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 5. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and 1999;134:11-14. staphylococcus in infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86.

31 ° Clinically shown to improve long-term cognitive outcomes through 5 years of age4,* ® Enfamil ° Shown to improve respiratory health through the fi rst 3 years of life 5,* ™ when infants were fed through 12 months Enspire • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is designed to: ° Support immune health by promoting the growth of benefi cial bacteria (bifi dobacteria and lactobacilli)6,7 Description/Indication ° Promote soft stools similar to those reported for breastfed infants8 Enfamil Enspire is a 20 Cal/fl oz milk-based, iron-fortifi ed, routine formula • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature for full-term infants 0–12 months. Enfamil Enspire has two components breast milk9,§ previously only largely available in breast milk: MFGM to foster cognitive development and lactoferrin to support immune health. • Non-GMO|| • Kosher

* Studies compared infants fed Enfamil with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. Product Features † Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women3. • Milk fat globule membrane (MFGM) provides the brain-building ‡ Enfamil Enspire has not been shown superior to the leading competitor in supporting mental, advantages of breast milk and is shown to improve cognitive outcomes visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% of 1 total fatty acids. at 12 months § Comparison based on whey-to-casein ratio of typical mature breast milk (15 days to 6 months • Lactoferrin, a key protein also in colostrum and breast milk, helps after birth). ® || Ingredients not genetically engineered. Trace amounts of genetically engineered material may support immune health. It brings Enfamil composition closer to human be present in the product, such as from manufacturing environments and process sources. For milk than ever before2 more information, visit enfamil.com/nonGMO. • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average3,†, and double the amount found in the leading competitor’s product‡: ° Clinically proven* to support mental, visual and immune system development

32 Enfamil® Enspire™ 33 oz No 12.9 300 270 10 8 5.4 40 1.81 1.22 0.68 9 5 6 4.1 30 32 15 2.8 1.89 14 43 29 220 78 53 390 63 43 320 1224 8.1 16.2 60 120 15 10.1 75 27 18.3 135 15 10.1 75 75 51 380 108 73 540 (mOsm/100 mL) mg

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References 1. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of Composition age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 2014;99:860-868. Ingredients: Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy 2. King JC Jr, Cummings GE, Guo N, et al. A double-blind, placebo-controlled, pilot study of bovine and high oleic sunfl ower oils), whey protein-lipid concentrate¶ (milk), whey lactoferrin supplementation in bottle-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:245-251 protein concentrate and less than 2%: lactoferrin, galactooligosaccharides#, 3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. polydextrose#, Mortierella alpina oil**, Crypthecodinium cohnii oil††, 4. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on potassium citrate, calcium carbonate, calcium phosphate, sodium chloride, childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. potassium chloride, ferrous sulfate, magnesium oxide, zinc sulfate, cupric 5. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906. 6. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and choline chloride, ascorbic acid, niacinamide, calcium pantothenate, galacto-oligosaccharides has a bifi dogenic effect in young infants. J Pediatr Gastroenterol Nutr. ribofl avin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, 2012;54:343-352. folic acid, vitamin K1, biotin, vitamin B12, inositol, vitamin E acetate, vitamin 7. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in A palmitate, nucleotides (cytidine 5’-monophosphate, disodium uridine infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86. 8. Ziegler E, Vanderhoof JA, Petschow B et al. Term infants fed formula supplemented with selected 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed 5’-monophosphate), taurine, L-carnitine. infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364. 9. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. ¶ A source of MFGM (milk fat globule membrane). 1992;81:107-112. # A type of prebiotic. 10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. ** A source of arachidonic acid (ARA). 1999;134:11-14. †† A source of docosahexaenoic acid (DHA).

34 Feeding Solution Formulas • DHA at the clinically proven‡ amount of 0.32% of total fatty acids, Enfamil the same amount as the worldwide breast milk average3,§, and double || ™ the amount found in the leading competitor’s product : NeuroPro ° Clinically proven‡ to support mental, visual and immune Gentlease® system development ° Clinically shown to improve long-term cognitive outcomes through 5 years of age4,‡ ° Shown to improve respiratory health through the fi rst 3 years of life 5,‡ Description/Indication when infants were fed through 12 months • Inositol at the average amount found in breast milk¶ Enfamil NeuroPro Gentlease is a 20 Cal/fl oz, milk-based infant formula designed to reduce fussiness, gas and crying1. It has an easy-to-digest gentle protein • Non-GMO# blend of MFGM and partially hydrolyzed protein. Enfamil NeuroPro Gentlease • Kosher has a fat-protein blend of MFGM and DHA previously found only in breast milk*. Emerging evidence from a recent clinical study showed MFGM in formula supports * In amounts supported by clinical research. † † As measured by Bayley-III cognitive score at 12 months in a different formula with MFGM added as an cognitive development similar to breast milk . ingredient. Long-Term Usage: Enfamil NeuroPro Gentlease is designed to provide the sole ‡ Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and source of nutrition for infants up to age 6 months and provide a major source of ARA; studied before the addition of prebiotics. § Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total nutrition for the remainder of the fi rst year. fatty acids) based on an analysis of 65 studies of 2,474 women3. || Enfamil NeuroPro Gentlease has not been shown superior to the leading competitor in supporting mental, visual and immune system development in infants. The level of DHA in Similac Pro-Advance™ is ~0.15% of total fatty acids. ¶ The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal6. Product Features # Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit • Designed to have an easy-to-digest gentle protein blend of MFGM and partially enfamil.com/nonGMO. hydrolyzed protein • Made with ingredients clinically shown to reduce fussiness, gas and crying in 24 hours1 • Infant formula that has MFGM and DHA is clinically shown to be a safe and well-tolerated source of nutrition2

36 Enfamil NeuroPro NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. (Normal Dilution) Per 100 Calories Per 100 mL Per 100 grams Per 100 Calories Per 100 mL Per 100 grams (5 ﬂ oz) Powder (510 Cal) (5 ﬂ oz) Powder (510 Cal) Protein, g 2.3 1.56 11.7 Biotin, mcg 3 2 15.3 Fat, g 5.3 3.6 27 Vitamin C (Ascorbic acid), mg 12 8.1 61 Linoleic acid, mg 780 530 4000 Choline, mg 24 16.2 122 Carbohydrate, g 10.8 7.3 55 Inositol, mg 24 16.2 122 Water, g 133 90 2.4 Minerals Vitamins/Other Nutrients Calcium, mg 82 55 420 ™

Vitamin A, IU 300 200 1530 Phosphorus, mg 46 31 230 Gentlease Vitamin D, IU 60 41 310 Magnesium, mg 8 5.4 41 Vitamin E, IU 2 1.35 10.2 Iron, mg 1.8 1.22 9.2 Vitamin K, mcg 9 6.1 46 Zinc, mg 1 0.68 5.1

Thiamin (Vitamin B1), mcg 80 54 410 Manganese, mcg 15 10.1 77

Riboﬂ avin (Vitamin B2), mcg 140 95 710 Copper, mcg 75 51 380 ® Vitamin B6, mcg 60 41 310 Iodine, mcg 15 10.1 77

Vitamin B12, mcg 0.3 0.2 1.53 Selenium, mcg 2.8 1.89 14.3 Niacin, mcg 1000 680 5100 Sodium, mg 36 24 184 Folic acid (Folacin), mcg 16 10.8 82 Potassium, mg 108 73 550 Pantothenic acid, mcg 500 340 2600 Chloride, mg 63 43 320

NUTRIENT FACTS Nutrient Density 20 Calories/ﬂ oz 20 Calories/ﬂ oz Protein (% Calories) 9 Potential Renal Solute Load (mOsm/100 mL)7 14 Fat (% Calories) 48 Osmolality (mOsm/kg water) 230 Carbohydrate (% Calories) 43 Osmolarity (mOsm/L) 210 Potential Renal Solute Load (mOsm/100 Calories)7 21 Lactose-free No

37 References Product Forms 1. Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch formulas Enfamil NeuroPro Gentlease is available in powder. For ordering information, occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65. 2. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of please refer to page 298. age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr. 2014;99:860-868. 3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 4. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on Composition childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. Ingredients: Powder: Corn syrup solids, vegetable oil (palm olein, coconut, soy 5. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic and high oleic sunfl ower oils), partially hydrolyzed nonfat milk and whey protein manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906. 6. Data on fi le. concentrate solids (soy), whey protein-lipid concentrate (milk)** and less than 2%: 7. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. †† ‡‡ Mortierella alpina oil , Schizochytrium sp. oil , calcium carbonate, sodium citrate, 1999;134:11-14. calcium phosphate, potassium chloride, magnesium ph osphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, ribofl avin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.

** A source of MFGM (milk fat globule membrane). †† A source of arachidonic acid (ARA). ‡‡ A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil NeuroPro™ Gentlease® contains milk and soy.

38 Enfamil NeuroPro

Notes

™

Gentlease

° Clinically shown to improve long-term cognitive outcomes through Enfamil 5 years of age3 ® ° Shown to improve respiratory health through the fi rst 3 years of life PREMIUM when infants were fed through 12 months4,† Gentlease® • Proprietary patented Triple Health Guard® blend of brain-nourishing DHA, 30 nutrients for growth, and vitamins and minerals for immune health • Inositol at the average amount found in breast milk|| • Designed to reduce fussiness, gas and crying in 24 hours1 Description/Indication • A special blend of easy-to-digest proteins, patterned after the blend of Enfamil PREMIUM Gentlease is a 20 Cal/fl oz, milk-based infant formula proteins found in breast milk*, that have been partially broken down designed to reduce fussiness, gas and crying1. It has an easy-to-digest milk • Has ~20% of lactose¶ as a source of carbohydrates; infants with protein blend patterned after breast milk (whey and casein in a 60:40 ratio)* transient lactase defi ciency generally can tolerate formulas with that has been partially broken down. The formula is nutritionally balanced some lactose and has docosahexaenoic acid (DHA) and arachidonic acid (ARA), nutrients • No artifi cial fl avors, sweeteners or colors also found in breast milk that promote brain and eye development. • Non-GMO# Long-Term Usage: Enfamil PREMIUM Gentlease is designed to provide the • Kosher sole source of nutrition for infants up to age 6 months and provide a major * Comparison to whey-to-casein ratio of typical mature breast milk (15 days to 6 months after source of nutrition for the remainder of the fi rst year. birth) prior to hydrolysis. † Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women2. Product Features § Enfamil PREMIUM Gentlease has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro- • DHA at the clinically proven† amount of 0.32% of total fatty acids, Advance™ is ~0.15% of total fatty acids. the same amount as the worldwide breast milk average2,‡, and double || The global average total amount of inositol in mature breast milk over the course of lactation is 5 § 22 mg/100 kcal . the amount found in the leading competitor’s product : ¶ Of a routine formula. ° Clinically proven† to support mental, visual and immune system # Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. development For more information, visit enfamil.com/nonGMO. Enfamil PREMIUM Gentlease ready-to-use formulation is not currently available in non-GMO. 40 Enfamil PREMIUM® Gentlease® 41 Per 100 mLPer 100 100 grams Per (5 fl oz) (5 fl 2.8 2.8 1.89 1.89 14.3 9 9 6.11 6.1 1 46 0.68 0.68 5.1 2.35.3 2.32 5.3 1.56 3.6 2 1.56 3.6 1.35 11.7 27 1.35 10.2 1.8 1.8 1.22 1.22 9.2 0.33 0.38 3 0.2 8 2 0.2 5.4 2 1.53 5.4 15.3 41 63 63 43 43 320 36 40 24 27 184 7515 75 15 51 10.1 51 10.1 380 77 15 15 10.1 10.1 77 10.860 10.8 60 7.3 41 7.3 41 55 310 80 80 54 54 410 60 60 41 41 310 1612242482 1646 12 24 24 82 10.8 46 8.1 16.2 16.2 55 10.8 31 8.1 16.2 16.2 82 55 31 122 61 122 420 230 108 108 73 73 550 780133300 780 133 300 530 90 200 530 90 200 4000 1.23 1530 140 140 95 95 710 500 500 340 340 2600 1000 1000 680 680 5100 Powder RTU Powder RTU (510 Cal) Powder for current information. Please see product label change. and ingredients are subject to Product nutrient values mg

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Ingredients: Ready To Use (32 fl oz bottle): Water, corn syrup solids, Product Forms partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), Enfamil PREMIUM® Gentlease® is available in powder and ready-to-use vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils), liquid. For ordering information, please refer to page 299. rice starch and less than 1%: Mortierella alpina oil**, Crypthecodinium cohnii oil††, diacetyl tartaric esters of mono- and diglycerides (DATEM), calcium carbonate, calcium phosphate, magnesium chloride, ferrous sulfate, sodium Composition chloride, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, ascorbic acid, vitamin E acetate, niacinamide, calcium Ingredients: Powder: Corn syrup solids, vegetable oil (palm olein, coconut, pantothenate, vitamin A palmitate, ribofl avin, vitamin B12, vitamin D3, thiamin soy and high oleic sunfl ower oils), partially hydrolyzed nonfat milk and whey hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, choline protein concentrate solids (soy) and less than 2%: Mortierella alpina oil**, chloride, inositol, taurine, L-carnitine. Crypthecodinium cohnii oil††, calcium carbonate, sodium citrate, calcium phosphate, potassium chloride, magnesium phosphate, ferrous sulfate, ** A source of arachidonic acid (ARA) zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium †† A source of docosahexaenoic acid (DHA) selenite, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, ribofl avin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, Potential Allergens vitamin A palmitate, taurine, L-carnitine. Enfamil PREMIUM Gentlease contains milk and soy.

42 Enfamil PREMIUM® Gentlease® . 43 J Pediatr . 2010;156:902-906. . J Pediatr manifestations respiratory and common in children. illnesses 1999;134:11-14. Data on ﬁ le. Data on ﬁ renal solute load in infancy. Renal solute load and potential Ziegler EE. SJ, Fomon allergic on incidence of of early nutrition The impact et al. Berseth CL, Khoury JC, EE, Birch 5. 6. 4. . 2007;85:1457-1464. . Am J Clin Nutr 2009;48:58-65. . 2013;98:403-412. . (Phila).

Am J Clin Nutr Clin Pediatr formulas occurs within 1 day. occurs within 1 day. formulas concentrations in human breast milk worldwide. concentrations in human breast milk worldwide. on childhood cognitive outcomes. outcomes. on childhood cognitive Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch to 2 commonly used Clinical response et al. SI, Stolz WH, Johnston CL, Berseth Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation Long-term effects of LCPUFA et al. Cheatham CL, SE, Carlson Colombo J, References 1. 2. 3. ° Clinically shown to improve long-term cognitive outcomes through 5 years of age3 ® Enfamil ° Shown to improve respiratory health through the fi rst 3 years of life Gentlease® when infants were fed through 12 months4,† • Designed to reduce fussiness, gas and crying in 24 hours1 • A special blend of easy-to-digest proteins, patterned after the blend of proteins found in breast milk*, that have been partially broken down • Has ~20% of lactose|| as a source of carbohydrates; infants with transient Description/Indication lactase defi ciency generally can tolerate formulas with some lactose Enfamil Gentlease is a 20 Cal/fl oz, milk-based infant formula designed • No artifi cial fl avors, sweeteners or colors to reduce fussiness, gas and crying1. It has an easy-to-digest milk protein • Kosher blend patterned after breast milk (whey and casein in a 60:40 ratio)* that has been partially broken down. The formula is nutritionally balanced and * Comparison to whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth) prior to hydrolysis. has docosahexaenoic acid (DHA) and arachidonic acid (ARA), nutrients also † Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA found in breast milk that promote brain and eye development. and ARA; studied before the addition of prebiotics. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation Long-Term Usage: Enfamil Gentlease is designed to provide the sole of total fatty acids) based on an analysis of 65 studies of 2,474 women2. § Enfamil Gentlease has not been shown superior to the leading competitor in supporting mental, source of nutrition for infants up to age 6 months and provide a major visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% of source of nutrition for the remainder of the fi rst year. total fatty acids. || Of a routine formula.

Product Features • DHA at the clinically proven† amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average2,‡, and double the amount found in the leading competitor’s product§: ° Clinically proven† to support mental, visual and immune system development

44 Enfamil® Gentlease® 45 15.3 Per 100 mLPer 100 100 grams Per 0.68 0.68 0.68 0.68 5.1 1.35 1.35 1.35 1.35 10.2 (5 fl oz) (5 fl 2.8 2.8 2.8 2.8 1.89 1.89 1.89 1.89 14.3 1111 1.8 1.8 1.8 1.8 1.22 1.22 1.22 1.22 9.2 66664.14.14.14.131 88885.45.45.45.441 99996.16.16.16.146 2.35.3 2.3 5.3 2.32222 5.3 2.3 5.3 1.56 3.6 1.55 3.6 1.55 3.6 1.56 3.6 11.7 27 0.3 0.333332222 0.3 0.3 0.2 0.2 0.2 0.2 1.53 751536 75 1563 36 75 15 63 36 75 15 63 36 51 10.1 63 24 51 10.1 43 24 10.1 51 43 24 10.1 51 43 24 77 380 43 184 320 15 15 15 15 10.1 10.1 10.1 10.1 77 2482 2446 82 24 46 82 24 46 82 16.2 46 55 16.2 31 16.2 55 31 16.2 55 31 122 55 31 420 230 10.8 10.860 10.880 60 10.8 80 60 7.3 80 60 7.3 80 41 7.3 54 41 7.3 54 41 55 54 41 54 310 410 6016 6012 16 60 12 16 60 12 16 41 12 10.8 41 10.8 8.1 41 10.8 8.1 41 10.8 8.1 310 82 8.1 61 108 108 108 108 73 73 73 73 550 800133133 133 133 90 860300 90 800 300140 90 860 300 140 90 540 300 140 580 200 2.4 140 540 200 95 580 200 95 200 4100 95 1530 95 710 500 500 500 500 340 340 340 340 2600 Powder oz 2 fl oz 6 fl oz 8 fl Powder oz 2 fl oz 6 fl oz 8 fl (510 Cal) Powder 1000 1000 1000 1000 680 680 680 680 5100 for current information. Please see product label change. and ingredients are subject to Product nutrient values mg

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Ingredients: Ready To Use (2 & 6 fl oz Nursette® bottles, 8 fl oz bottle): Product Forms Water, corn syrup solids, partially hydrolyzed nonfat milk and whey protein Enfamil® Gentlease® is available in powder and ready-to-use liquid. concentrate solids (soy), vegetable oil (palm olein, soy, coconut and high For ordering information, please refer to page 298. oleic sunfl ower oils), rice starch and less than 1%: Mortierella alpina oil¶, Crypthecodinium cohnii oil#, vitamin B12, vitamin D3, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, Composition ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, choline chloride, inositol, folic acid, vitamin K1, biotin, diacetyl tartaric esters of mono- and Ingredients: Powder: Corn syrup solids, partially hydrolyzed nonfat milk diglycerides (DATEM), calcium carbonate, calcium phosphate, magnesium and whey protein concentrate solids (soy), vegetable oil (palm olein, soy, chloride, ferrous sulfate, zinc sulfate, sodium citrate, cupric sulfate, coconut and high oleic sunfl ower oils) and less than 2%: Mortierella manganese sulfate, potassium iodide, sodium selenite, taurine, L-carnitine. alpina oil¶, Crypthecodinium cohnii oil#, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, ribofl avin, vitamin B6 ¶ A source of arachidonic acid (ARA). hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, # A source of docosahexaenoic acid (DHA). biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium selenite, sodium citrate, potassium chloride, potassium iodide, taurine, L-carnitine. Potential Allergens Enfamil Gentlease contains milk and soy.

46 Enfamil® Gentlease® . 47 J Pediatr . 2010;156:902-906. . J Pediatr manifestations respiratory and common in children. illnesses 1999;134:11-14. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. renal solute load in infancy. Renal solute load and potential Ziegler EE. SJ, Fomon allergic on incidence of of early nutrition The impact et al. Berseth CL, Khoury JC, EE, Birch 5. 4. . 2007;85:1457-1464. . Am J Clin Nutr . 2013;98:403-412. . . 2009;48:58-65. . (Phila)

Am J Clin Nutr Clin Pediatr formulas occurs within 1 day. occurs within 1 day. formulas concentrations in human breast milk worldwide. concentrations in human breast milk worldwide. on childhood cognitive outcomes. outcomes. on childhood cognitive Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch to 2 commonly used Clinical response et al. SI, Stolz WH, Johnston CL, Berseth Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation Long-term effects of LCPUFA et al. Cheatham CL, SE, Carlson Colombo J, References 1. 2. 3. • Designed to have an easy-to-digest protein blend of MFGM and partially Enfamil® hydrolyzed protein ™ • Has ingredients clinically shown to reduce fussiness, gas and crying in Enspire 24 hours1,* Gentlease® • Infant formula that has MFGM and DHA is clinically shown to be a safe and well-tolerated source of nutrition2 • DHA at the clinically proven‡ amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average4,§, and double the || Description/Indication amount found in the leading competitor’s product : Clinically shown to support cognitive and visual development5 Enfamil Enspire Gentlease is a 20 Cal/fl oz milk-based, iron-fortifi ed infant ° formula designed to ease fussiness, gas and crying. Enfamil Enspire Gentlease ° Clinically shown to improve long-term cognitive outcomes through is the trusted Gentlease formula, designed to reduce fussiness, gas and crying 5 years of age6,‡ in 24 hours1,*, now has MFGM and lactoferrin. MFGM and lactoferrin are two • Inositol at the average amount found in breast milk¶ ingredients previously only found in breast milk†: MFGM to foster cognitive • Non-GMO# development and lactoferrin to support immune health. • Kosher Long-Term Usage: Enfamil Enspire Gentlease is designed to have the sole source of nutrition for infants up to age 6 months and a major source of * Studied before the reformulation of Gentlease. † In amounts supported by clinical research. nutrition for the remainder of the fi rst year. ‡ Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. § Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women4. || Enfamil Enspire Gentlease has not been shown superior to the leading competitor in supporting Product Features mental, visual and immune system development in infants. The level of DHA in Similac Pro-Ad- • Milk fat globule membrane (MFGM) provides brain-building benefi ts and vance™ is ~0.15% of total fatty acids. 2 ¶ The global average total inositol level in mature breast milk over the course of lactation is 22 is shown to support cognitive outcomes at 12 months mg/100 kcal7. • Lactoferrin, a key protein also in colostrum and breast milk, helps support # Ingredients not genetically engineered. Trace amounts of genetically engineered material may be 3 present in the product, such as from manufacturing environments and process sources. For more immune health . information, visit enfamil.com/nonGMO.

48 Enfamil® Enspire™ Gentlease® 49 oz 14.2 210 No No 8 81.81 5.4 1.22 0.68 40 9 5 32 15 2.8 1.89 14 46 31 230 82 55 410 24 16.2 120 63 43 320 1224 8.1 16.2 60 120 15 10.1 75 40 27 200 15 10.1 75 75 51 380 108 73 540 (mOsm/100 mL) mg

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(% Calories) , Vitamin E Vitamin K Thiamin Vitamin D Vitamin A Water Vitamins/Other Nutrients Vitamins/Other Linoleic acid Carbohydrate Potential Renal Solute Load Ribofl Pantothenic acid Folic acid Vitamin B Niacin Fat Carbohydrate Carbohydrate Vitamin B Protein Nutrient Density 20 Calories/fl NUTRIENT FACTS Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS Fat Whey:Casein Ratio Osmolality References Product Forms 1. Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch formulas Enfamil® Enspire™ Gentlease® is available in powder. For ordering occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65. 2. Timby N, Domellöf E, Hernell O et al. Neurodevelopment, nutrition, and growth until 12 mo of information, please refer to page 298. age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 2014;99:860-868. 3. King JC Jr, Cummings GE, Guo N et al. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. J Pediatr Gastroenterol Nutr 2007;44:245-251. Composition 4. Brenna JT, Varamini B, Jensen RG et al. Docosahexaenoic and arachidonic acid concentrations in Ingredients: Corn syrup solids, vegetable oil (palm olein, coconut, soy human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 5. Birch EE, Garfi eld S, Castañeda Y, et al. Visual acuity and cognitive outcomes at 4 years of age in and high oleic sunfl ower oils), partially hydrolyzed nonfat milk and whey a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant protein concentrate solids (soy), whey protein-lipid concentrate (milk)**, formula. Early Hum Dev. 2007;83:279-284. and less than 2%: Lactoferrin, Mortierella alpina oil††, Schizochytrium 6. Colombo J, Carlson SE, Cheatham CL et al. Long-term effects of LCPUFA supplementation on sp. oil‡‡, sodium citrate, calcium phosphate, potassium chloride, calcium childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. 7. Data on fi le. carbonate, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, 1999;134:11-14. choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, ribofl avin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.

** A source of MFGM (milk fat globule membrane). †† A source of arachidonic acid (ARA). ‡‡ A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil Enspire Gentlease contains milk and soy.

50 Enfamil

Notes

® Enspire

™ Gentlease

51 • DHA at the clinically proven§ amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average2,||, and double Enfamil the amount found in the leading competitor’s product¶: o Clinically proven§ to support mental, visual and immune system ™ NeuroPro development o Clinically shown to improve long-term cognitive outcomes through Sensitive 5 years of age3,§ o Shown to improve respiratory health through the fi rst 3 years of life when infants were fed through 12 months4,§ # Description/Indication • Inositol at the average amount found in breast milk • Non-GMO** Enfamil NeuroPro Sensitive is a 20 Cal/fl oz, milk-based infant formula designed for sensitive tummies. It is specially formulated for infants with • Kosher lactose sensitivity* and has easy-to-digest proteins. Enfamil NeuroPro Sensitive has a fat-protein blend of MFGM and DHA previously found only * Not for infants with galactosemia. in breast milk†. Emerging evidence from a clinical study showed MFGM in † In amounts supported by clinical research. ‡ ‡ As measured by Bayley-III cognitive score at 12 months in a different formula with MFGM infant formula supports cognitive development similar to breast milk . added as an ingredient. § Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without Long-Term Usage: Enfamil NeuroPro Sensitive is designed to provide the DHA and ARA; studied before the addition of prebiotics. sole source of nutrition for infants up to age 6 months and provide a major || Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women2. source of nutrition for the remainder of the fi rst year. ¶ Enfamil NeuroPro Sensitive has not been shown superior to the leading competitor’s product in supporting mental, visual and immune system development in infants. The level of DHA in Similac Pro-Advance™ is ~0.15% of total fatty acids. # The global average total inositol amount in mature breast milk over the course of lactation is 22 mg/100 kcal5. ** Ingredients not genetically engineered. Trace amounts of genetically engineered material may Product Features be present in the product, such as from manufacturing environments and process sources. For • Easy-to-digest formula specially designed for lactose sensitivity* more information, visit enfamil.com/nonGMO. • Infant formula that has MFGM and DHA is clinically shown to be a safe and well-tolerated source of nutrition1

52 Enfamil NeuroPro™ Sensitive 53 oz No 14 270 300 6 81.81 5.4 1.22 0.68 40 9 5 32 15 2.8 1.89 14 59 40 300 88 60 440 24 16.2 120 67 45 340 1224 8.1 16.2 60 120 15 10.1 75 33 22 165 15 10.1 75 75 51 380 110 74 550 (mOsm/100 mL) mg

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, , Osmolarity Osmolality Potential Renal Solute Load Iron Zinc Magnesium Phosphorus Minerals Calcium Inositol Chloride Potassium Sodium Vitamin C Choline Biotin Manganese Copper Selenium Iodine oz 20 Calories/fl 9 43 48 21 Lactose-free for current information. see product label Please to change. are subject values and ingredients Product nutrient 6 29 1.35 6.1 10 45 5.3 3.6 27 2.2 1.49 11 0.3 0.2 1.5 70 47 350 10.9 7.4 55 16 10.8 80 80 54 400 60 41 300 300 200 1500 132 89 2.4 500 340 2500 780 530 3900 140 95 700 (5 fl oz) (5 fl (500 Cal) Powder oz) (5 fl (500 Cal) Powder 1000 680 5000 (mOsm/100 Calories) mcg

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†† A source of MFGM (milk fat globule membrane). ‡‡ A source of arachidonic acid (ARA). §§ A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil NeuroPro Sensitive contains milk and soy.

54 Enfamil NeuroPro

Notes

™

Sensitive

55 o Clinically shown to improve long-term cognitive outcomes through 5 years of age2,† o Shown to improve respiratory health through the fi rst 3 years of life Enfamil when infants were fed through 12 months3,† ® ™ • A Natural Defense Dual Prebiotic blend of GOS (galactooligosaccharides) PREMIUM A2 and PDX (polydextrose) at 4 g/L is designed to: o Support immune health by promoting the growth of benefi cial bacteria (bifi dobacteria and lactobacilli)4,5 o Promote soft stools similar to those reported for breastfed infants6 Description/Indication • Inositol at the average amount found in breast milk|| • Non-GMO¶ Enfamil PREMIUM A2 is a milk-based, iron-fortifi ed formula for full-term • No artifi cial growth hormones# infants 0–12 months. Enfamil PREMIUM A2 has easy-to-digest proteins • Gluten-free and contains milk from cows that produce only the A2 protein*.

* From skim milk powder. † Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation Product Features of total fatty acids) based on an analysis of 65 studies of 2,474 women1. • A2 beta-casein is similar to that found in breast milk § Enfamil PREMIUM A2 has not been shown superior to the leading competitor in supporting mental, visual and immune system development in infants. The level of DHA in Similac Pro-Advance™ • Most ordinary milk has a mix of A1 and A2 proteins. A1-producing is ~0.15% of total fatty acids. cows emerged through commercial farming practices || The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal7. † • DHA at the clinically proven amount of 0.32% of total fatty acids, ¶ Ingredients not genetically engineered. Trace amounts of genetically engineered material may be the same amount as the worldwide breast milk average1,‡, and present in the product, such as from manufacturing environments and process sources. For more double the amount found in the leading competitor’s product§: information, visit enfamil.com/nonGMO. # No signiﬁ cant difference has been shown between milk derived from rbST-treated and non-rbST- o Clinically proven to support mental, visual and immune system treated cows. development

56 Enfamil PREMIUM™ A2 57 oz No No 12.5 300 270 8 81.81 5.4 1.22 0.68 41 9.2 5.1 3 2 15.3 2.8 1.89 14.3 43 29 220 78 53 400 24 16.2 122 63 43 320 1224 8.1 16.2 61 122 15 10.1 77 27 18.3 138 15 10.1 77 75 51 380 108 73 550 (mOsm/100 mL) mg

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, , Osmolarity Osmolality Potential Renal Solute Load Iron Zinc Magnesium Phosphorus Minerals Calcium Inositol Chloride Potassium Sodium Vitamin C Choline Biotin Manganese Copper Selenium Iodine oz 20 Calories/fl 8 60:40 44 Lactose-free 48 18.6 Galactose-free for current information. see product label Please to change. are subject values and ingredients Product nutrient 8 29 1.35 6.1 10.2 4.6 5.3 3.6 27 2 1.35 10.2 0.3 0.2 1.53 60 41 310 11.3 7.6 58 16 10.8 82 80 54 410 60 41 310 300 200 1530 133 90 2.5 500 340 2600 780 530 4000 140 95 710 (5 fl oz) (5 fl Powder (510 kcals) oz) (5 fl Powder (500 Cal) 1000 680 5100 (mOsm/100 Calories) mcg

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, Vitamin E Vitamin K Thiamin Vitamin D Vitamin A Water Vitamins/Other Nutrients Vitamins/Other Linoleic acid Carbohydrate Ribofl Pantothenic acid Folic acid Vitamin B Niacin Potential Renal Solute Load Fat Carbohydrate Fat Vitamin B Whey:Casein Ratio Protein NUTRIENT FACTS Nutrient Density 20 Calories/fl Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS References Product Forms 1. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in Enfamil PREMIUM™ A2 is available in powder. For ordering information, human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 2. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on please refer to page 299. childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. 3. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906. 4. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and Composition galacto-oligosaccharides has a bifi dogenic effect in young infants. J Pediatr Gastroenterol Nutr. Ingredients: Powder: Skim milk**, lactose, vegetable oil (palm oil, coconut, 2012;54:343-352. 5. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in soy and high oleic sunfl ower oils), whey protein concentrate and less than infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86. †† †† ‡‡ 2%: Galactooligosaccharides , polydextrose , Mortierella alpina oil , 6. Ziegler E, Vanderhoof JA, Petschow B et al. Term infants fed formula supplemented with selected Crypthecodinium cohnii oil§§, calcium carbonate, calcium phosphate, cupric blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed sulfate, ferrous sulfate, magnesium oxide, manganese sulfate, potassium infants. J Pediatr Gastroenterol Nutr. 2007;44:359-364. 7. Data on fi le. chloride, potassium citrate, potassium iodide, sodium chloride, sodium 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. selenite, zinc sulfate, soy lecithin, inositol, choline chloride, ascorbic acid, 1999;134:11-14. biotin, calcium pantothenate, folic acid, niacinamide, ribofl avin, thiamin hydrochloride, vitamin B12, vitamin B6 hydrochloride, vitamin D3, vitamin K1, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.

** A source of A2 milk. †† A type of prebiotic. ‡‡ A source of arachidonic acid (ARA). §§ A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil PREMIUM A2 contains milk and soy.

58 Enfamil PREMIUM

Notes

™ A2

59 • Plant-sourced protein ® • Milk-free and suitable for infants with lactose intolerance Enfamil • Dairy-free for when parents want to avoid cow’s milk in their baby’s diet ® ProSobee • No artiﬁ cial ﬂ avors, sweeteners or colors • Lactose-free • Kosher (Pareve ingredients; manufactured on dairy equipment)

* Studies compared infants fed Enfamil with DHA and ARA vs. discontinued Enfamil without DHA Description/Indication and ARA; studied before the addition of prebiotics. Enfamil ProSobee is a 20 Cal/ﬂ oz soy-based formula for the routine feeding † Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women1. of infants with feeding issues resulting from sensitivity to milk-based ‡ Enfamil ProSobee has not been shown superior to the leading competitor in supporting mental, formula. Enfamil ProSobee is for babies with sensitive tummies when a visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% of total fatty acids. soy formula is preferred. Enfamil ProSobee is lactose-free. § vs. the same infants at the beginning of the study. Long-Term Usage: Enfamil ProSobee is designed to provide a sole source of nutrition for infants up to age 6 months, and provide a major source of nutrition through 12 months of age when indicated. Product Forms Enfamil ProSobee is available in powder, ready-to-use liquid and concentrate. For ordering information, please refer to page 300. Product Features • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average1,†, and double the amount found in the leading competitor’s product‡: ° Clinically shown to improve long-term cognitive outcomes through 5 years of age2 vs. prior Enfamil® without DHA • Clinically proven to reduce fussiness and gas in 24 hours3,§

60 Enfamil® ProSobee® 61 15.3 Per 100 mLPer 100 Per 100 grams 1.35 1.35 1.35 1.35 10.2 (5 fl oz) (5 fl 2.8 2.8 2.8 2.8 1.89 1.89 1.89 1.89 14.2 1.81.2 1.8 1.2 1.8 1.2 1.8 1.2 1.22 0.81 1.22 0.81 1.22 0.81 1.22 0.81 9.2 6.1 88885.45.45.45.441 66664.14.14.14.131 99996.16.16.16.146 2222 33332222 5.3 5.3 5.3 5.3 3.6 3.6 3.6 3.6 27 0.3 0.3 0.3 0.3 0.2 0.2 0.2 0.2 1.53 2.5 2.5 2.5 2.5 1.69 1.69 1.69 1.69 12.7 36 36 36 36 24 24 24 24 183 15 15 15 15 10.1 10.1 10.1 10.1 76 75 75 75 75 51 51 51 51 380 80 80 80 80 54 54 54 54 410 25 25 25 25 16.9 16.9 16.9 16.9 127 69 69 69 69 47 47 47 47 350 24 24 24 24 16.2 16.2 16.2 16.2 122 60 60 60 60 41 41 41 41 310 12 12 12 12 8.1 8.1 8.1 8.1 61 10.6 10.6 10.6 10.6 7.2 7.2 7.2 7.2 54 16 16 16 16 10.8 10.8 10.8 10.8 81 8090 80 90 80 90 80 90 54 61 54 61 54 61 54 61 410 460 60 60 60 60 41 41 41 41 310 Powder oz RTU 2 fl oz RTU 8 fl oz Conc 13 fl Powder oz RTU fl 2 oz RTU 8 fl oz Conc 13 fl (510 Cal) Powder 120 120 120 120 81 81 81 81 610 105 105 105 105 71 71 71 71 530 300 300 300 300 200 200 200 200 1530 133 133 134 134 90 90 91 91 2.6 500 500 500 500 340 340 340 340 2500 800860 860 860 540 580 580 580 4100 1000 1000 1000 1000 680 680 680 680 5100 Please see product label for current information. change. and ingredients are subject to Product nutrient values mg

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, Sodium Potassium Selenium Iodine Chloride Zinc Manganese Copper Iron Phosphorus Magnesium Minerals Calcium Inositol Thiamin Vitamin K Vitamin D Vitamin E Vitamins/Other Nutrients Vitamin A Vitamin C Choline Biotin Carbohydrate Water Linoleic acid Folic acid Pantothenic acid Niacin Ribofl Vitamin B Vitamin B (Normal Dilution) Per 100 Calories NUTRIENTS Fat Protein NUTRIENT FACTS Nutrient Density 20 Calories/fl oz 20 Calories/fl oz Protein (% Calories) 10 Potential Renal Solute Load (mOsm/100 mL)4 15.6 Fat (% Calories) 48 Osmolality (mOsm/kg water) 200 (2 fl oz) 178 (Pwd) 170 (8 fl oz RTU, 13 fl oz Conc) Carbohydrate (% Calories) 42 Osmolarity (mOsm/L) 180 (2 fl oz) 160 (Pwd) 155 (8 fl oz RTU, 13 fl oz Conc) Potential Renal Solute Load (mOsm/100 Calories)4 23 Lactose-free Yes

B6 hydrochloride, folic acid, vitamin K1, biotin, mono- and diglycerides, Composition L-methionine, choline chloride, carrageenan, inositol, taurine, L-carnitine. Ingredients: Powder: Corn syrup solids (54%), vegetable oil (26%) (palm Ingredients: Ready To Use (8 fl oz bottle): Water (87%), corn syrup solids olein, coconut, soy and high oleic sunfl ower oils), soy protein isolate (14%) (7%), vegetable oil (palm olein, soy, coconut and high oleic sunfl ower and less than 2%: calcium phosphate, potassium chloride, sodium citrate, oils) (3%), soy protein isolate (2%) and less than 1%: Mortierella alpina calcium carbonate, magnesium chloride, magnesium phosphate, potassium oil||, Crypthecodinium cohnii oil¶, calcium phosphate, potassium citrate, citrate, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium sodium chloride, calcium carbonate, potassium chloride, magnesium selenite, Mortierella alpina oil||, Crypthecodinium cohnii oil¶, L-methionine, phosphate, magnesium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, vitamin potassium iodide, sodium selenite, soy lecithin, mono- and diglycerides, D3, ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, L-methionine, carrageenan, choline chloride, ascorbic acid, vitamin E vitamin K1, biotin, vitamin B12, inositol, taurine, vitamin E acetate, L-carnitine, acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin vitamin A palmitate. hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic acid, vitamin K1, ® Ingredients: Ready To Use (2 fl oz Nursette bottle): Water (87%), corn biotin, inositol, vitamin B12, vitamin D3, taurine, L-carnitine. syrup solids (7%), vegetable oil (palm olein, soy, coconut and high oleic Ingredients: Concentrate (13 fl oz can): Water (75%), corn syrup solids sunfl ower oils) (3%), soy protein isolate (2%) and less than 1%: Mortierella (14%), vegetable oil (palm olein, soy, coconut and high oleic sunfl ower alpina oil|||, Crypthecodinium cohnii oil¶, calcium phosphate, potassium oils) (6%), soy protein isolate (4%) and less than 1%: Mortierella alpina citrate, calcium carbonate, sodium chloride, magnesium chloride, oil||, Crypthecodinium cohnii oil¶, mono- and diglycerides, soy lecithin, magnesium phosphate, potassium chloride, ferrous sulfate, zinc sulfate, carrageenan, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin cupric sulfate, potassium iodide, sodium selenite, soy lecithin, ascorbic acid, K1, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin B12, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline vitamin B12, vitamin D3, thiamin hydrochloride, ribofl avin, vitamin chloride, inositol, calcium carbonate, calcium phosphate, magnesium

62 Enfamil® ProSobee® . 63 J Pediatr . 2007;85:1457-1464. . Am J Clin Nutr Am J Clin . 2013;98:403-412. . . 2009;48:58-65. . (Phila)

Am J Clin Nutr Clin Pediatr on childhood cognitive outcomes. outcomes. on childhood cognitive 1 day. formulas occurs within 1999;134:11-14. concentrations in human breast milk worldwide. concentrations breast milk worldwide. in human Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation Long-term effects of LCPUFA et al. Cheatham CL, SE, Carlson Colombo J, used switch Clinical response to 2 commonly et al. Stolz SI, WH, Johnston Berseth CL, Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. renal solute load in infancy. Renal solute load and potential Ziegler EE. SJ, Fomon Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid and arachidonic Docosahexaenoic et al. RG, Jensen B, Varamini JT, Brenna 2. 3. 4. 1. References contains soy. ®

ProSobee ®

Enfamil Potential Allergens citrate, potassium chloride, L-methionine, taurine, L-carnitine. taurine, L-methionine, chloride, potassium citrate, of arachidonic acid (ARA). A source || acid (DHA). A source of docosahexaenoic ¶ sulfate, potassium iodide, sodium selenite, sodium chloride, potassium chloride, sodium sodium selenite, iodide, potassium sulfate, chloride, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, zinc sulfate, ferrous magnesium phosphate, chloride, Product Features ® ® Enfamil • Proprietary Triple Health Guard blend of brain-nourishing DHA, ® Natural Defense Dual Prebiotic blend designed to support immune Reguline health and 30 nutrients for growth • DHA at the clinically proven† amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average1,‡, and double the amount found in the leading competitor’s product§: ° Clinically shown to improve long-term cognitive outcomes Description/IndicationDescription/Indica through 5 years of age2,† Enfamil RegulineReguline is a 20 Cal/flCal/fl ozo infant formula specifi cally designed • A Natural Defense Dual Prebiotic blend to help support digestive to help support digestivedigestive health and promote soft, comfortable stools. health and designed to promote benefi cial bacteria in the digestive * Prebiotic blendPrebiotic blend worksworks inin 1 weekweek . It is designed to be fed when stooling tract and soften stools within 1 week of use3-5,* issues, such as occasional diffidiffi ccult bowel movements, are causes of ® ® • Easy-to-digest proteins that are partially hydrolyzed parental concern. EnfamilEnfamil ReRegulinegul has the Enfamil Natural Defense Dual Prebiotic blend that works like fi ber to promote soft stools within 1 week • 50% of carbohydrates from lactose and for as long as the baby consumes the formula. Enfamil Reguline has • Complete nutrition appropriate for infants to continue feeding easy-to-digest proteins that are partially hydrolyzed. through 12 months of age to help support digestive health throughout the fi rst year Enfamil Reguline can be used as an everyday formula throughout an • Kosher infant’s fi rst year of life. * Proven in Enfamil® Infant formula. Long-Term Usage: Enfamil Reguline is designed to provide the † Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA sole source of nutrition for infants up to age 6 months and provide a and ARA; studied before the addition of prebiotics. ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation major source of nutrition for the remainder of the fi rst year. of total fatty acids) based on an analysis of 65 studies of 2,474 women1. § Enfamil Reguline has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% of total fatty acids.

64 Enfamil® Reguline® 65 oz 14 No 250 230 6 1 0.68 5.1 81.5 5.4 1.01 41 7.6 6 4.1 30 3 2 15.2 2.8 1.89 14.2 46 31 230 82 55 420 1224 8.1 16.2 61 122 63 43 320 15 10.1 76 36 24 183 15 10.1 76 75 51 380 108 73 550 (mOsm/100 mL) mg

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, , Lactose-free Osmolarity Osmolality Potential Renal Solute Load Iron Zinc Magnesium Phosphorus Minerals Calcium Inositol Vitamin C Choline Chloride Sodium Potassium Biotin Manganese Copper Selenium Iodine oz 20 Calories/fl 9 43 48 21 for current information. see product label Please to change. are subject values and ingredients Product nutrient 60:40 6 29 1.35 6.1 10.2 46 5.3 3.6 27 2.3 1.55 11.7 0.3 0.2 1.52 60 41 300 11.1 7.5 56 16 10.8 81 80 54 410 60 41 300 300 200 1520 133 90 2.4 780 530 4000 500 340 2500 140 95 710 (5 fl oz) (5 fl (510 Cal) Powder oz) (5 fl (510 Cal) Powder 1000 680 5100 (mOsm/100 Calories) mcg

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(% Calories) , Thiamin Vitamin E Vitamin K Vitamin D Vitamin A Water Vitamins/Other Nutrients Vitamins/Other Linoleic acid Carbohydrate Fat Ribofl Niacin Folic acid Pantothenic acid Vitamin B Vitamin B Potential Renal Solute Load Fat Carbohydrate Whey:Casein Ratio Nutrient DensityProtein 20 Calories/fl NUTRIENT FACTS Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS References Product Forms 1. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in Enfamil® Reguline® is available in powder. For ordering information, please human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 2. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on refer to page 300. childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. 3. Ashley C, Johnston WH, Harris CL, et al. Growth and tolerance of infants fed formula supplemented with polydextrose (PDX) and/or galactooligosaccharides (GOS): double-blind, randomized, controlled trial. Nutr J. 2012:11:38. 4. Salminen S et al. Early Gut Colonization With Lactobacilli and Staphylococcus in Infants: The Composition Hygiene Hypothesis Extended. J Pediatr Gastroenterol Nutr 2016;62(1):80-86. 5. Scalabrin D et al. New Prebiotic Blend of Polydextrose and Galacto-oligosaccharides Has a Ingredients: Partially hydrolyzed nonfat milk and whey protein Bifi dogenic Effect in Young Infants. J Pediatr Gastroenterol Nutr 2012;54(3):343-352 concentrate solids (soy), vegetable oil (palm olein, coconut, soy and 6. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. high oleic sunfl ower oils), corn syrup solids, lactose and less than 1999;134:11-14. 2%: polydextrose||, galactooligosaccharides||, Mortierella alpina oil¶, Crypthecodinium cohnii oil#, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium selenite, sodium citrate, potassium chloride, potassium iodide, taurine, L-carnitine.

|| A type of prebiotic. ¶ A source of arachidonic acid (ARA). # A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil Reguline contains milk and soy.

66 Enfamil

Notes

® Reguline

67 •A Natural Defense Dual Prebiotic blend to help support digestive health 2,§ ™ • Clinically proven to reduce spit-up by over 50% Enfamil A.R. • Meets refl ux reduction guidance of the American Academy of Pediatrics1 • Nutritionally balanced with a nutrient profi le similar to routine infant formula • Less caloric and more nutritionally balanced than adding rice cereal to formula Description/IndicationDescription/Indi • Thickens further in the stomach, allowing easier fl ow through a Enfamil A.R. is a 20 Cal/flCal/fl ozoz,, thickened, milk-based infant formula that standard nipple reduces spit-upspit-up in 1 week andan is appropriate for the fi rst 12 months. • Milk-based formula has 20:80 whey-to-casein ratio and unmodifi ed, EnfamilEnfamil A.R. is clinically proprovenve to reduce frequency and volume of pregelatinized, high amylopectin rice starch regurgitation and meets the reflr ux reduction guidance of the American • Kosher AcademyAcademy ooff Pediatrics1,2.

* Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without Long-Term Usage: Enfamil A.R. is designed to provide a sole source of DHA and ARA; studied before the addition of prebiotics. nutrition for infants up to age 6 months, and provide a major source of † Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard 3 nutrition until 12 months. deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women . ‡ Enfamil A.R. has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% of total fatty acids. § Based on a published, double-blind, randomized, controlled trial of Enfamil A.R. with infants Product Features who spit up frequently (5 or more spit-ups per day) comparing frequency and volume of spit-up after feeding Enfamil A.R. to the same infants at the beginning of the study. • Proprietary Triple Health Guard® blend of brain-nourishing DHA, a Natural Defense® Dual Prebiotic blend designed to support immune health and 30 nutrients for growth * • DHA at the clinically proven amount of 0.32% of total fatty acids, Product Forms the same amount as the worldwide breast milk average3,†, and double the amount found in the leading competitor’s product‡: Enfamil A.R. is available in powder and ready-to-use liquid. For ordering information, please refer to page 297. ° Clinically shown to improve long-term cognitive outcomes through 5 years of age4,* 68 Enfamil A.R.™ 69 Liquid (500 Cal) Powder Per 100 mLPer 100 Per 100 grams Powder Liquid (5 ﬂ oz) (5 ﬂ 29 2 9 1.35 6.1 1.35 6.1 9.9 45 2.55.1 2.5 5.1 1.69 3.4 1.69 3.4 12.4 25 0.336 0.381.8 31 6 0.22.8 8 1.8 1 2 0.2 4.1 2.8 1.22 5.4 2 0.68 4.0 1.49 1.89 1.21 5.4 0.67 14.9 30 1.89 9 40 5 13.9 Powder 60 60 41 40 300 11.380 11.3 80 7.6 7.6 54 56 54 400 60161224 607853 16 1215 2475 41 4015 7840 53 10.875 15 8.1 16.2 75 300 15 53 40 10.8 36 75 8.1 16.2 10.1 51 10.1 53 80 36 27 51 119 60 10.1 51 10.1 390 260 27 51 75 370 75 200 370 133300 132 300 90 89 200 2.2 200 1490 780 780140 530 140 530 95 94 3900 700 108 108 73 73 540 500 500 340 340 2500 1000 1000 680 670 5000 Please see product label for current information. change. and ingredients are subject to Product nutrient values mg

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Composition Ingredients: Powder: Nonfat milk, vegetable oil (palm olein, coconut, biotin, vitamin B12, soy lecithin, mono- and diglycerides, choline chloride, soy and high oleic sunfl ower oils), rice starch, lactose, maltodextrin, carrageenan, inositol, vitamin D3, taurine, L-carnitine. galactooligosaccharides||, polydextrose|| and less than 1%: Mortierella Ingredients: Ready To Use (8 fl oz bottle): Water, nonfat milk, vegetable alpina oil¶, Crypthecodinium cohnii oil#, calcium carbonate, ferrous sulfate, oil (palm olein, soy, coconut and high oleic sunfl ower oils), lactose and less zinc sulfate, sodium citrate, cupric sulfate, manganese sulfate, sodium than 2%: galactooligosaccharides||, polydextrose||, Mortierella alpina oil¶, selenite, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, Crypthecodinium cohnii oil#, rice starch, maltodextrin, calcium carbonate, vitamin D3, ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, folic potassium chloride, magnesium phosphate, sodium chloride, sodium citrate, acid, vitamin K1, biotin, vitamin B12, inositol, vitamin E acetate, vitamin A ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium palmitate, taurine, L-carnitine. iodide, sodium selenite, soy lecithin, mono- and diglycerides, ascorbic Ingredients: Ready To Use (2 fl oz Nursette® bottle): Water, nonfat milk, acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils), lactose palmitate, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic and less than 2%: galactooligosaccharides||, polydextrose||, Mortierella acid, vitamin K1, biotin, vitamin B12, choline chloride, carrageenan, inositol, alpina oil¶, Crypthecodinium cohnii oil#, rice starch, maltodextrin, calcium vitamin D3, taurine, L-carnitine. carbonate, potassium chloride, magnesium phosphate, sodium chloride, || A type of prebiotic. sodium citrate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese ¶ A source of arachidonic acid (ARA). sulfate, potassium iodide, sodium selenite, ascorbic acid, vitamin E # A source of docosahexaenoic acid (DHA). acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic acid, vitamin K1,

70 Enfamil A.R.™ . 71 J Pediatr . Pediatrics . 2007;85:1457-1464. . (Phila). 2003;42:483– 495. (Phila). Am J Clin Nutr . 2013;98:403-412. . Clin Pediatr Am J Clin Nutr Gastroesophageal refl ux: management guidance for the pediatrician. management pediatrician. guidance for the ux: Gastroesophageal refl 2013;131:e1684-e1695. parallel group trial in 104 infants placebo-controlled randomized, double-blind, multicenter, ux. with symptomatic gastroesophageal refl concentrations in human breast milk worldwide. outcomes. on childhood cognitive 1999;134:11-14. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. load and potential renal solute load in infancy. Renal solute Ziegler EE. SJ, Fomon Lightdale JR, Gremse DA, Section on Gastroenterology, Hepatology, and Nutrition. and Nutrition. Hepatology, on Gastroenterology, Section Gremse DA, JR, Lightdale a infant formula: of a pre-thickened cacy Effi et al. Harris CL, Moran JR, JA, Vanderhoof and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, supplementation Long-term effects of LCPUFA et al. Cheatham CL, SE, Carlson Colombo J, References 5. 1. 2. 3. 4.

contains milk and soy. contains ™

Enfamil A.R. Enfamil Potential Allergens Potential Notes

72 Allergy Formulas for Infants and Toddlers Nutramigen® • Nutramigen with Enfl ora LGG works fast and is clinically proven to: ° Start to manage colic due to cow’s milk allergy in as early as the with Enflora™ fi rst feeding, with 90% of infants improving within 48 hours1,† ° Result in 0% blood in stool after 4 weeks of feeding2 ®* LGG ° Help infants consume milk protein without an allergic response in as early as 6 months of feeding3 * LGG® is a registered trademark of Chr. Hansen A/S. • Helps reduce the likelihood of other allergic manifestations at 3 years of age4,‡ Description/Indication • Contains the probiotic branded LGG: LGG promotes a healthy GI and immune system by supporting a Nutramigen with Enfl ora LGG is a 20 Cal/fl oz, iron-fortifi ed, lactose-free, ° balanced immune response, colonizing the infant’s gut to support a hypoallergenic infant formula designed for infants who have food allergies healthy microfl ora and promoting normal gut barrier function including cow’s milk allergy. Nutramigen with Enfl ora LGG has extensively • DHA and ARA to support brain and eye development5-12: hydrolyzed casein protein to help avoid an immune system response by § reducing the allergen exposure, and the probiotic branded LGG to help ° DHA at the clinically proven amount of 0.32% of total fatty acids, 13,|| support the strength of the intestinal barrier and support digestive health. the same amount as the worldwide breast milk average , and double the amount found in the leading competitor’s product¶ Long-Term Usage: In cases of continued food allergies or intolerances, • Nutramigen protein clinically researched in over 75 studies† Nutramigen with Enfl ora LGG is sometimes used as a milk substitute in the • Lactose-free diet of children beyond 12 months of age. When Nutramigen is used as a # milk substitute beyond 12 months of age, the total calcium content of the diet • Has no sucrose as a carbohydrate source should be assessed. • No artifi cial growth hormones** Extended use of Nutramigen with Enfl ora LGG (or other infant formulas) as † Some studies were prior to the addition of DHA, ARA and LGG. a sole source of diet is most appropriately monitored by physicians and ‡ Rhinoconjunctivitis, urticaria, eczema and asthma at 3 years compared to Nutramigen without LGG. Feeding began at 4 months or older in the study. nutritionists on a case-by-case basis. § Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics. || Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women13. Product Features ¶ Nutramigen with Enfl ora LGG has not been shown superior to the leading competitor in promoting brain and eye development. The level of DHA in Similac Pro-Advance™ is ~0.15% • Hypoallergenic protein source (extensively hydrolyzed casein) of total fatty acids. # When hereditary fructose intolerance is a concern. ** No signifi cant difference has been shown between milk derived from rbST-treated and non- 74 rbST-treated cows. Nutramigen® with Enflora™ LGG® 75 oz Yes 16.9 300 270 14 81.8 1.221 5.4 9 0.68 40 5 3215 2.8 1.89 14 52 35 260 94 64 470 24 16.2 120 86 58 430 1224 8.1 16.2 60 120 25 16.9 125 47 32 240 15 10.1 75 75 51 380 110 74 550 (mOsm/100 mL) mg

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, , Osmolarity Osmolality Lactose-free Potential Renal Solute Load Iron Zinc Magnesium Phosphorus Minerals Calcium Inositol Chloride Potassium Sodium Vitamin C Choline Biotin Manganese Copper Selenium Iodine oz 20 Calories/fl 41 48 25 11 for current information. see product label Please to change. are subject values and ingredients Product nutrient 14 29 1.35 6.1 10 45 5.3 3.6 27 2.8 1.89 14 0.3 0.2 1.5 60 41 300 10.3 7 52 16 10.8 80 8090 54 61 400 450 60 41 300 300 200 1500 131 89 2.3 500 340 2500 780 530 3900 (5 fl oz) (5 fl (500 Cal) Powder oz) (5 fl (500 Cal) Powder 1000 680 5000 (mOsm/100 Calories) mcg

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Composition Ingredients: Corn syrup solids (47%), vegetable oil (palm olein, coconut, soy and high oleic sunfl ower oils) (26%), casein hydrolysate (milk) (17%)††, modifi ed corn starch (4%) and less than 2%: Mortierella alpina oil‡‡, Schizochytrium sp. oil§§, Lactobacillus rhamnosus GG||||, calcium citrate, calcium phosphate, potassium chloride, potassium citrate, sodium citrate, calcium hydroxide, magnesium oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline chloride, ascorbic acid, niacinamide, calcium pantothenate, vitamin D3, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, inositol, vitamin A palmitate, vitamin E acetate, L-cystine, L- tyrosine, L-tryptophan, taurine, L-carnitine.

†† Modiﬁ ed to be better tolerated in milk-allergic babies. ‡‡ A source of arachidonic acid (ARA). §§ A source of docosahexaenoic acid (DHA). |||| Branded as LGG®, a registered trademark of Chr. Hansen A/S.

76 Nutramigen® with Enflora™ LGG® . 77 . J Pediatr J Pediatr Am J Clin Nutr . 2007;85:1457-1464. . . 2005;81:197-203. . Am J Clin Nutr Early Hum Dev . 2003;142:669-677. . J Pediatr . 2003;17:A727-A728. Abstract 445.1. 2003;17:A727-A728. . . 2000;31:540-553. . FASEB J FASEB weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a polyunsaturateswithout long-chain formula with or weaned to at 4 to 6 months: trial. randomized clinical 18-month old infants receiving dietary18-month old infants polyunsaturated long-chain fatty acids (LCPUFAs) [abstract]. composition of long-chain polyunsaturatedcomposition of long-chain fatty acids on later development. visual Gastroenterol Nutr polyunsaturated fatty acid-supplemented or control formula for 12 mo. polyunsaturated fatty or control formula for 12 mo. acid-supplemented 2005;81:871-879. acids availability in the diet and visual acuity. acids availability visual acuity. in the diet and concentrations in human breast milk worldwide. concentrations milk worldwide. in human breast 1999;134:11-14. Hoffman DR, Birch EE, Birch DG, et al. Impact of early dietary intake and blood lipid et al. Birch DG, Birch EE, Hoffman DR, Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturationVisual fed long-chain of term infants et al. Wheaton DH, YS, Castañeda Birch EE, Morale SE, Hoffman DR, Castañeda YS, et al. Duration polyunsaturated of long-chain fatty et al. YS, Castañeda Hoffman DR, Morale SE, Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid Docosahexaenoic al. et Jensen RG, B, Varamini Brenna JT, Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. Renal solute load and potential renal solute load in infancy. Ziegler EE. SJ, Fomon Hoffman DR, Birch EE, Castañeda YS, et al. Visual function in breast-fed term infants breast-fed term Visual function in et al. YS, Castañeda Birch EE, DR, Hoffman Hoffman DR, Birch EE, Castañeda YS, et al. Maturation of visual and mental function in et al. YS, Castañeda EE, Birch Hoffman DR, 8. 9. 10. 11. 12. 13. 14.

Dev Med J Allergy Immunol. Clin J . 1998;44:201-209. . . 1989;83:262-266. . Pediatr Res Pediatr Pediatrics . 2010;156:397-401. . J Pediatr . 2017;139:1906-1913. . . 2002;75:570-580. . . 2000;42:174-181. . Am J Clin Nutr formula-fed infants: a double-blind crossover study. crossover study. a double-blind infants: formula-fed containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic rhamnosus GG reduces the occurrence containing Lactobacillus randomized controlled trial. 3-year allergy: milk manifestations in children with cow’s Allergy Clin Immunol J with blood in the stools and presumptive allergic colitis compared with extensively and presumptive allergic colitis with blood in the stools alone. hydrolyzed formula trial. a randomized milk allergy: with cow’s acquisition in infants 2012;129:580-582. of term infants. acid and arachidonic acid in the diet polyunsaturated fatty acid supplementation at of formula in term infants after weaning 6 wk of age. of long-chain polyunsaturated fatty acids and mental development in term infants. of long-chain polyunsaturated fatty acids and mental development in term infants. Child Neurol Lothe L, Lindberg T. Cow’s milk whey protein elicits symptoms of infantile colic in colicky of infantile elicits symptoms milk whey protein Cow’s T. Lindberg L, Lothe formula Extensively hydrolyzed casein et al. G, Bedogni Costanzo M, Di Berni Canani R, GG improves recovery Lactobacillus infants in et al. M, Fanelli Laforgia N, Baldassarre ME, tolerance Effect of Lactobacillus GG on et al. G, Terrin R, Nocerino Berni Canani R, Visual acuity and the essentiality of docosahexaenoic et al. Uauy R, Hoffman DR, Birch EE, Birch EE, Hoffman DR, Castañeda YS, et al. A randomized controlled trial of long-chain et al. YS, Castañeda Hoffman DR, Birch EE, Birch EE, Garfi eld S, Hoffman DR, et al. A randomized controlled trial of early dietary supply et al. Hoffman DR, eld S, Garfi Birch EE, References 1. 4. 2. 3. 5. 7. 6. ® Product Features Nutramigen • Hypoallergenic protein source (extensively hydrolyzed casein) (Liquids) • Clinically proven to effectively manage colic due to cow's milk allergy in 48 hours1,2,* • Nutritionally complete • DHA and ARA, important nutrients also found in breast milk that promote brain and eye development3-10 Description/Indication • Fatty acid profi le patterned after breast milk11,12,† • Lactose-free Nutramigen is an iron-fortifi ed, hypoallergenic infant formula designed for infants who are allergic to the intact proteins in cow’s milk and soy * Studied before the addition of DHA and ARA. formulas. Nutramigen has extensively hydrolyzed casein protein to help † Comparison based on fatty acid profi le of typical mature U.S. breast milk. avoid an immune response by reducing the allergen exposure and is proven effective for managing colic due to cow’s milk allergy. Long-Term Usage: Nutramigen is designed to provide a sole source of nutrition for infants up to age 6 months, and provide a major source of Product Forms nutrition through 12 months of age. Normally, in feeding infants, gradual Nutramigen is available in ready-to-use liquid and concentrate. For ordering introduction of solid foods after 4–6 months of age is an important information, please refer to page 300. developmental as well as nutritional step. In cases of continued food allergies or intolerances, Nutramigen is sometimes used as a milk substitute in the diet of children beyond 12 months of age. When Nutramigen is used as a milk substitute beyond 12 months of age, the total calcium content of the diet should be assessed. Extended use of Nutramigen (or other infant formulas) as a sole source of diet is most appropriately monitored by physicians and nutritionists on a case-by-case basis.

78 Nutramigen® (Liquids) 79 Per 100 mL Per 100 5.4 5.4 5.4 5.4 5.4 1.35 1.35 1.35 1.35 1.35 77777 0.68 0.68 0.68 0.68 0.68 16.2 16.2 16.2 16.2 16.2 (5 fl oz) (5 fl 999996.1 6.1 6.1 6.1 6.1 6.1 6.1 6.1 999996.1 22222 2.8 2.8 2.8 2.8 2.8 1.89 1.89 1.89 1.89 1.89 3333322222 5.3 5.3 5.3 5.3 5.3 3.6 3.6 3.6 3.6 3.6 1.8 1.8 1.8 1.8 1.8 1.2211111 1.22 1.22 1.22 1.22 0.3 0.3 0.3 0.3 0.3 0.2 0.2 0.2 0.2 0.2 2.8 2.8 2.8 2.8 2.8 1.89 1.89 1.89 1.89 1.89 24 24 24 24 24 24 24 24 24 24 16.2 16.2 16.2 16.2 16.2 50 50 50 50 50 34 34 34 34 34 47 47 47 47 47 32 32 32 32 32 15 15 15 15 15 10.1 10.1 10.1 10.1 10.1 75 75 75 75 75 51 51 51 51 51 12 12 12 12 12 8.1 8.1 8.1 8.1 8.1 10.3 10.3 10.3 10.3 10.3 86 86 86 86 86 58 58 58 58 58 25 25 25 25 25 16.9 16.9 16.9 16.9 16.9 16 16 16 16 16 10.8 10.8 10.8 10.8 10.8 8090 80 90 80 90 80 90 80 90 54 61 54 61 54 61 54 61 54 61 60 60 60 60 60 41 41 41 41 41 9452 94 52 94 52 94 52 94 52 64 35 64 35 64 35 64 35 64 35 88888 300 300 300 300 300 200 200 200 200 200 132 132 132 133 132 89 89 89 90 89 500 500 500 500 500 340 340 340 340 340 780 780 780 780 780 530 530 530 530 530 530530 530 530 780780 780 780780 530 110 110 110 110 110 74 74 74 74 74 1000 1000 1000 1000 1000 680 680 680 680 680 2 fl oz RTU2 fl oz RTU 6 fl oz RTU 8 fl oz Conc 13 fl oz RTU 32 fl oz RTU 2 fl oz RTU 6 fl oz RTU 8 fl oz Conc 13 fl oz RTU 32 fl Please see product label for current information. change. Product nutrient values and ingredients are subject to mg

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, Inositol Thiamin Vitamin K Vitamin D Vitamin E Vitamins/Other Nutrients Vitamin A Sodium Potassium Selenium Iodine Vitamin C Choline Biotin Water Carbohydrate Linoleic acid Chloride Copper Folic acid Pantothenic acid Zinc Manganese Iron Niacin Ribofl Vitamin B Vitamin B Phosphorus Magnesium Minerals Calcium (Normal Dilution) Per 100 Calories NUTRIENTS Fat Protein NUTRIENT FACTS Nutrient Density 20 Calories/fl oz 20 Calories/fl oz 2 & 6 fl oz 13 fl oz 8 & 32 fl oz All versions RTU Concentrate RTU Protein (% Calories) 11 Potential Renal Solute Load (mOsm/100 mL)13 16.9 16.9 16.9 Fat (% Calories) 48 Osmolality (mOsm/kg water) 320 260 270 Carbohydrate (% Calories) 41 Osmolarity (mOsm/L) 280 230 240 Potential Renal Solute Load (mOsm/100 Calories)13 25 Lactose-Free Yes Yes Yes

sulfate, sodium iodide, sodium selenite, carrageenan, choline chloride, ascorbic Composition acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, ® Ingredients: Ready To Use (2 fl oz Nursette bottle): Water (87%), corn syrup thiamin hydrochloride, ribofl avin, vitamin D3, vitamin B6 hydrochloride, folic solids (5%), vegetable oil (palm olein, soy, coconut and high oleic sunfl ower acid, vitamin K1, biotin, L-cystine, inositol, L-tyrosine, L-tryptophan, vitamin B12, oils) (3%), casein hydrolysate‡ (milk) (2%), modifi ed corn starch (2%) and less taurine, L-carnitine. than 1%: Mortierella alpina oil§, Schizochytrium sp. oil||, carrageenan, vitamin Ingredients: Ready To Use (8 fl oz bottle): Water (87%), corn syrup solids A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, (5%), vegetable oil (palm olein, coconut, soy and high oleic sunfl ower oils) (3%), ribofl avin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium casein hydrolysate‡ (milk) (2%), modifi ed corn starch (2%) and less than 1%: pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, Mortierella alpina oil§, Schizochytrium sp. oil||, calcium phosphate, potassium calcium phosphate, magnesium oxide, ferrous sulfate, zinc sulfate, manganese citrate, calcium carbonate, potassium chloride, sodium citrate, magnesium sulfate, cupric sulfate, sodium iodide, sodium selenite, sodium citrate, oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium citrate, potassium chloride, citric acid, taurine, L-cystine, L-tyrosine, sodium iodide, sodium selenite, carrageenan, citric acid, choline chloride, L-tryptophan, L-carnitine. ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, Ingredients: Ready To Use (6 fl oz Nursette bottle): Water (87%), corn syrup vitamin A palmitate, thiamin hydrochloride, ribofl avin, vitamin D3, vitamin solids (5%), vegetable oil (palm olein, coconut, soy and high oleic sunfl ower B6 hydrochloride, folic acid, vitamin K1, biotin, L-cystine, inositol, L-tyrosine, oils) (4%), casein hydrolysate‡ (milk) (2%), modifi ed corn starch (2%) and less L-tryptophan, vitamin B12, taurine, L-carnitine. than 1%: Mortierella alpina oil§, Schizochytrium sp. oil||, calcium phosphate, Ingredients: Ready To Use (32 fl oz bottle): Water (87%), corn syrup solids potassium citrate, calcium carbonate, potassium chloride, sodium citrate, (5%), vegetable oil (palm olein, soy, coconut, and high oleic sunfl ower oils) (4%), magnesium oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese casein hydrolysate‡ (milk) (2%), modifi ed corn starch (2%) and less than 1%:

80 Nutramigen® (Liquids) . 81 . J Pediatr Dev Med J Pediatr Am J Clin Nutr . 1998;44:201-209. . . 1989;83:262-266. . . 2005;81:197-203. . . 1992;120(suppl): S56-S61. 1992;120(suppl): . Pediatr Res Pediatr Pediatrics J Pediatr . San Diego, Calif: Academic Press;1995. Calif: San Diego, . Early Hum Dev . 2003;142:669-677. . J Pediatr . 2002;75:570-580. . . 1982;70:7-10. . . 2003;17:A727-A728. Abstract 445.1. Abstract 2003;17:A727-A728. . . 2000;31:540-553. . Handbook of Milk Composition . 2000;42:174-181. . Pediatrics FASEB J FASEB Am J Clin Nutr formula-fed infants: a double-blind crossover study. crossover study. a double-blind infants: formula-fed blind study. acid in the diet of term infants. acid and arachidonic of long-chain polyunsaturated fatty infants. and mental development in term acids Child Neurol polyunsaturated fatty acid supplementation at of formula in term infants after weaning 6 wk of age. a polyunsaturatesweaned to formula with or without long-chain at 4 to 6 months: trial. randomized clinical 18-month-old infants receiving dietary long-chain polyunsaturated fatty acids (LCPUFAs) [abstract]. composition of long-chain polyunsaturated fatty acids on later visual development. Gastroenterol Nutr polyunsaturated fatty acid-supplemented or control formula for 12 mo. polyunsaturated fatty acid-supplemented or control formula for 12 mo. 2005;81:871-879. acids availability in the diet and visual acuity. acids availability visual acuity. in the diet and 1999;134:11-14. Morale SE, Hoffman DR, Castañeda YS, et al. Duration polyunsaturated of long-chain fatty et al. YS, Castañeda Hoffman DR, Morale SE, Innis SM. Human milk and formula fatty acids. Human milk and formula fatty acids. Innis SM. Jensen RG, ed. ed. Jensen RG, Renal solute load and potential renal solute load in infancy. Ziegler EE. SJ, Fomon Lothe L, Lindberg T. Cow’s milk whey protein elicits symptoms of infantile colic in colicky of infantile elicits symptoms milk whey protein Cow’s T. Lindberg L, Lothe a double- as a cause of infantile colic: milk formula Cow’s Jakobsson I. T, Lindberg Lothe L, Visual function in breast-fed term infants et al. YS, Castañeda Birch EE, Hoffman DR, Birch EE, Hoffman DR, Uauy RD, et al. Visual acuity and the essentiality of docosahexaenoicVisual acuity and the essentiality et al. Uauy RD, DR, Hoffman Birch EE, early dietaryA randomized controlled trial of supply et al. Hoffman DR, S, eld Garfi Birch EE, controlled trial of long-chainA randomized et al. YS, Castañeda DR, Hoffman Birch EE, Hoffman DR, Birch EE, Castañeda YS, et al. Maturation function in of visual and mental et al. YS, Castañeda Birch EE, Hoffman DR, Impact of early dietary intake and blood lipid et al. Birch DG, Birch EE, Hoffman DR, Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturationVisual of term infants fed long-chain et al. Wheaton DH, YS, Castañeda Birch EE, References 1. 2. 6. 3. 4. 5. 7. 8. 9. 10. 11. 12. 13. , || oil , thiamin hydrochloride, hydrochloride, thiamin , 1 , niacinamide, folic acid, acid, folic niacinamide, , , carrageenan, vitamin A vitamin carrageenan, , || 12 Water (75%), corn syrup solids corn syrup (75%), Water Schizochytrium sp. oil , § , niacinamide, folic acid, calcium folic acid, niacinamide, , oil 12 , thiamin hydrochloride, ribofl avin, avin, ribofl thiamin hydrochloride, , can): oz 1 (milk) (4%), modifi ed corn starch (3%) modifi (milk) (4%), ‡ Schizochytrium sp. Schizochytrium , , vitamin E acetate, vitamin K vitamin E acetate, vitamin , hydrochloride, vitamin B vitamin hydrochloride, § 3 Mortierella alpina 6 oil Concentrate (13 fl (13 Concentrate

contains milk and soy. Nutramigen is hypoallergenic. Rarely, Rarely, Nutramigen is hypoallergenic. contains milk and soy. ® hydrochloride, vitamin B hydrochloride, 6

, vitamin E acetate, vitamin K vitamin vitamin E acetate, , 3

and less than 1%: and less than 1%: Potential Allergens Nutramigen D acetylated monoglycerides, carrageenan, vitamin A palmitate, vitamin A palmitate, vitamin carrageenan, acetylated monoglycerides, L-carnitine. L-tryptophan, L-tyrosine, L-cystine, taurine, acid, selenite, sodium citrate, potassium citrate, potassium chloride, citric potassium chloride, citrate, potassium citrate, sodium selenite, to be better tolerateded in milk-allergic babies. Modifi ‡ A source of arachidonic acid (ARA). § || acid (DHA). A source of docosahexaenoic sulfate, manganese sulfate, cupric sulfate, sodium iodide, sodium sodium iodide, cupric sulfate, manganese sulfate, sulfate, carbonate, calcium phosphate, magnesium oxide, ferrous sulfate, zinc ferrous sulfate, magnesium oxide, calcium phosphate, carbonate, pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium inositol, choline chloride, acid, ascorbic biotin, pantothenate, Ingredients: hydrolysate casein oils) (7%), (10%), vegetable oil (palm olein, soy, coconut and high oleic sunfl ower coconut and high oleic sunfl soy, oil (palm olein, vegetable (10%), vitamin B Mortierella alpina Mortierella been reported. however, allergic reactions to extensively hydrolyzed casein formulas have allergic reactions to extensively hydrolyzed however,

palmitate, vitamin D palmitate, taurine, L-cystine, L-tyrosine, L-tryptophan, L-carnitine. L-tryptophan, L-tyrosine, L-cystine, taurine, selenite, sodium citrate, potassium citrate, potassium chloride, citric acid, citric acid, potassium chloride, potassium citrate, sodium citrate, selenite, zinc sulfate, manganese sulfate, cupric sulfate, potassium iodide, sodium potassium iodide, cupric sulfate, manganese sulfate, zinc sulfate, calcium carbonate, calcium phosphate, magnesium oxide, ferrous sulfate, sulfate, ferrous magnesium oxide, calcium phosphate, calcium carbonate, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, inositol, choline chloride, ascorbic acid, biotin, calcium pantothenate, ribofl avin, vitamin B vitamin avin, ribofl ® • Increased vitamins and minerals as compared to Nutramigen® Nutramigen with Enfl ora™ LGG® infant with Enflora™ • 26 vitamins and minerals for growing toddlers ®* • Lactose-free LGG Toddler • Has no sucrose‡ as a carbohydrate source • No artifi cial growth hormones§ * LGG® is a registered trademark of Chr. Hansen A/S.

† Studied in infants. Description/Indication ‡ When hereditary fructose intolerance is a concern. § No signifi cant difference has been shown between milk derived from rbST-treated and non- Nutramigen with Enfl ora LGG Toddler is a 20 Cal/fl oz, iron-fortifi ed, rbST-treated cows. hypoallergenic infant formula for older infants and toddlers with food allergies including cow’s milk allergy. It is designed to help meet their growing nutritional needs. Nutramigen with Enfl ora LGG Toddler has extensively hydrolyzed casein protein to help avoid an immune system response by Product Forms reducing the allergen exposure, and the probiotic branded LGG to help Nutramigen with Enfl ora LGG Toddler is available in powder. For ordering support the strength of the intestinal barrier and help support digestive information, please refer to page 300. health.

Product Features • Hypoallergenic protein source (extensively hydrolyzed casein) • Contains the probiotic branded LGG: ° LGG promotes a healthy GI and immune system by supporting a balanced immune response, colonizing the gut to support a healthy microﬂ ora and promoting normal gut barrier function† • DHA and iron—building blocks of a toddler’s brain

82 Nutramigen® with Enflora™ LGG® Toddler 83 oz Yes 15.9 300 270 1 1.61.1 1.08 0.74 7.7 5.3 2.2 1.49 10.6 2.5 1.69 12 10 6.8 48 72 49 350 17 11.5 82 80 54 380 1924 12.8 16.2 91 115 50 34 240 37 25 178 17.6 11.9 84 75 51 360 130 88 620 122 83 590 (mOsm/100 mL) mg

mg mg mcg

, (mOsm/L) , mg , (mOsm/kg water)

mcg , (Ascorbic acid),

mg , mg

mg mg mcg ,

, , mcg , , mcg

, , mg mg

, , Osmolality Osmolarity Lactose-free Potential Renal Solute Load Iron Zinc Magnesium Phosphorus M inerals Calcium Inositol Chloride Potassium Sodium Vitamin C Choline Biotin Copper Manganese Selenium Iodine oz 20 Calories/fl 39 51 24 10 for current information. see product label Please to change. are subject values and ingredients Product nutrient 1 1.65 1.12 7.9 4.3 2.9 21 2.5 1.69 12 0.3 0.2 1.44 13 8.8 62 60 41 290 12.8 8.7 61 16 10.8 77 300 200 1440 132 89 1.62 660 450 3200 640 430 3100 180 122 860 110 74 530 154 104 740 (5 fl oz) (5 fl (480 Cal) Powder oz) (5 fl (480 Cal) Powder 1540 1040 7400 (mOsm/100 Calories) mcg

), mcg

2 mcg ),

1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B g

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|| Modiﬁ ed to be better tolerated in milk-allergic babies. ¶ A source of arachidonic acid (ARA). # A source of docosahexaenoic acid (DHA). ** Branded as LGG®, a registered trademark of Chr. Hansen A/S.

Potential Allergens Nutramigen® with Enﬂ ora™ LGG® Toddler contains milk and soy. Nutramigen with Enﬂ ora LGG Toddler is hypoallergenic. Allergic reactions to extensively hydrolyzed casein formulas are not commonly reported.

84 Nutramigen

Notes

® with Enflora

™

LGG

® Toddler

85 When PurAmino is used as a milk substitute, the total calcium content of the diet should be assessed. ™ PurAmino Extended use of PurAmino (or other infant formulas) as a sole source of diet is most appropriately monitored by physicians and nutritionists on a case-by-case basis.

Description/IndicationDescription/In PRODUCT FEATURES • Hypoallergenic, 100% free amino acids as nitrogen source: PurAmino is a 20 Cal/flCal/fl oz,oz iron-fortifi ed, hypoallergenic, amino acid-based infantinfant formulaformula forfor the dietarydiet management of infants with severe cow’s ° 100% of infants fed PurAmino had no allergic reactions/ milk protein allergy, notnot effectivelye managed by an extensively hydrolyzed adverse events1 formula.f lPAi PurAmino is i also l indicated for the dietary management of infants ° 2.8 g protein equivalent/100 Calories with multiple food protein allergies. It may also be suitable for conditions • Formulated with 33% medium-chain triglycerides (MCT) oil to help requiring an elemental diet such as protein maldigestion, malabsorption, facilitate fat absorption short bowel syndrome and eosinophilic esophagitis. • Nutritionally complete: Long-Term Usage: PurAmino is designed to provide a sole source of ° Can be sole source of nutrition up to age 6 months nutrition for infants up to age 6 months and provide a major source of ° Can be major source of nutrition through 24 months nutrition through 24 months of age, when indicated. Normally, in feeding ° Dietary reference intakes include a recommendation for fi ber infants, gradual introduction of solid foods after 4–6 months of age is an for >12 months of age important developmental as well as nutritional step. In cases of severe and • DHA and ARA, important nutrients also found in breast milk that multiple food allergies or intolerances, PurAmino is sometimes continued support brain and eye development2-7 as a milk substitute in the diet of children. This and similar supplemental • Lactose-free use of PurAmino in the diet make an important contribution in supporting 1 the maintenance of adequate nutrition in such patients. • Demonstrated to support normal growth in healthy infants • Kosher, Halal

86 PurAmino™ 87 oz Yes 17.2 350 320 8 81.8 1.221 5.4 9 0.68 40 5 2.8 1.9 14 32 15 64 44 320 86 58 430 24 16.3 120 25 17 125 47 32 240 15 10.2 75 1224 8.2 16.3 60 120 75 51 380 116 79 580 110 75 550 (mOsm/100 mL) mg

mg mg mcg

, (mOsm/L) , mg , (mOsm/kg water)

mcg , (Ascorbic acid),

mg , mg

mg mg mcg ,

, , mcg , , mcg

, , mg mg

, , Osmolality Osmolarity Lactose-free Potential Renal Solute Load Iron Zinc Magnesium Phosphorus Minerals Calcium Chloride Potassium Sodium Inositol Manganese Copper Selenium Iodine Vitamin C Choline Biotin oz 20 Calories/fl 47 42 25 11 for current information. see product label Please to change. are subject values and ingredients Product nutrient 8 29 1.36 6.1 10 45 0.3 0.2 1.5 5.3 3.6 27 2.8 1.9 14 60 41 300 16 10.9 80 10.6 7.2 53 8090 54 61 400 450 60 41 300 300 200 1500 133 90 1.76 500 340 2500 860 580 4300 (5 fl oz) (5 fl (500 Cal) Powder oz) (5 fl (500 Cal) Powder 1000 680 5000 (mOsm/100 Calories) mcg

), mcg

2 g mcg ),

, 1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B

(% Calories) mcg g

, , avin avin g (% Calories)

, Vitamin E Vitamin K Thiamin Vitamin D Vitamin A Water Vitamins/Other Nutrients Vitamins/Other Riboﬂ Pantothenic acid Folic acid Vitamin B Niacin Linoleic acid Carbohydrate Fat Carbohydrate Vitamin B Potential Renal Solute Load Fat Nutrient DensityProtein 20 Calories/ﬂ NUTRIENT FACTS Protein equivalent Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS Product Forms Potential Allergens PurAmino™ is available in powder. For ordering information, please refer to PurAmino contains soy oil. PurAmino is hypoallergenic. page 301.

References 1. Burks W, Jones SM, Berseth CL, et al. Hypoallergenicity and effects on growth and tolerance of Composition a new amino acid-based formula with docosahexaenoic acid and arachidonic acid. J Pediatr. 2008;153:266-271. Ingredients: Corn syrup solids (46%), amino acids (potassium aspartate, 2. Birch EE, Hoffman DR, Castañeda YS, et al. A randomized controlled trial of long–chain L-leucine, L-lysine hydrochloride, L-proline, L-alanine, L-valine, polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of L-isoleucine, L-serine, L-threonine, L-glutamine, L-tyrosine, L-aspartic acid, age. Am J Clin Nutr. 2002;75:570–580. 3. Hoffman DR, Birch EE, Castañeda YS, et al. Maturation of visual and mental function in 18– L-arginine, L-phenylalanine, L-histidine, L-cystine, glycine, L-tryptophan, month old infants receiving dietary long–chain polyunsaturated fatty acids [abstract]. FASEB J. L-methionine) (18%), high oleic sunfl ower oil (9%), medium chain 2003;17:A727–A728. Abstract 445.1. triglycerides (MCT) oil (9%), soy oil (8%), modifi ed tapioca starch (4%), 4. Hoffman DR, Birch EE, Castañeda YS, et al. Visual function in breast–fed term infants weaned to † formula with or without long–chain polyunsaturates at 4 to 6 months: a randomized clinical trial. J and less than 2%: Mortierella alpina oil*, Schizochytrium sp. oil , choline Pediatr. 2003;142:669–677. chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, 5. Hoffman DR, Birch EE, Birch DG, et al. Impact of early dietary intake and blood lipid composition ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, vitamin D3, of long–chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol Nutr. 2000;31:540–553. folic acid, vitamin K1, biotin, taurine, vitamin E acetate, L-carnitine, vitamin A 6. Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturation of term infants fed long–chain palmitate, vitamin B12, calcium phosphate, potassium citrate, sodium polyunsaturated fatty acid–supplemented or control formula for 12 mo. Am J Clin Nutr. citrate, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, 2005;81:871–879. manganese sulfate, sodium chloride, sodium iodide, sodium selenite. 7. Morale SE, Hoffman DR, Castañeda YS, et al. Duration of long–chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197–203. 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. * A source of arachidonic acid (ARA). 1999;134:11–14. † A source of docosahexaenoic acid (DHA).

88 PurAmino

Notes

™

89 When PurAmino Jr is used as a milk substitute, the total calcium content of the diet should be assessed.

™ PurAmino Jr Extended use of PurAmino Jr (or other medical foods for children) is most appropriately monitored by physicians and nutritionists on a case-by-case basis.

Description/Indication Product Features PurAmino Jr is a 30 Cal/fl oz, iron-fortifi ed, hypoallergenic, amino acid- • Hypoallergenic, 100% free amino acids as nitrogen source based medical food for the dietary management of children with severe • The only amino acid product for one year and up that has DHA, an cow’s milk protein allergy, not effectively managed by an extensively important nutrient that helps support brain and eye development hydrolyzed formula. PurAmino Jr is also indicated for the dietary management of children with multiple food protein allergies. It may also • Formulated with 33% medium-chain triglycerides (MCT) oil to help be suitable for conditions requiring an elemental diet such as protein facilitate fat absorption maldigestion, malabsorption, short bowel syndrome and eosinophilic • Has calcium and protein for growing children esophagitis. • Nutritionally complete* • Lactose-free Long-Term Usage: PurAmino Jr is designed to provide a major source • No artifi cial colors or sweeteners of nutrition for children age 1 year and up. In cases of severe and multiple food allergies or intolerances, PurAmino Jr is sometimes continued as a • Non-GMO† milk substitute in the diet of children. This and similar supplemental use of • Kosher, Halal PurAmino Jr in the diet make an important contribution in supporting the maintenance of adequate nutrition in such patients. * Dietary reference intakes include a recommendation for fi ber for >12 months of age. † Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

90 PurAmino™ Jr 91 oz Yes 29 540 630 1 32.84.1 3 2.8 4.1 14.5 13.5 20 1.730.82 1.73 0.82 8.5 4 30 30 145 15.3 15.3 75 4310.2 43 10.2 210 50 5161 51 61 250 300 9215.3 92 15.3 450 75 16.3 16.3 80 153 153 750 133 133131 650 131 640 (mOsm/100 mL) mg

mg , mcg , mg mcg

, (mOsm/L) , mg , (mOsm/kg water)

mcg , , mcg , (Ascorbic acid), (Ascorbic

mg , mg

mg mg mcg ,

, , mcg , ,

, mg mg

, , Lactose-free Potential Renal Solute Load Osmolality Osmolarity Choline Copper Iodine Potassium Chloride Chromium Selenium Molybdenum Sodium Magnesium Iron Phosphorus Inositol Minerals Calcium Zinc Manganese Vitamin C Vitamin oz 30 Calories/fl 29 13 45 42 for current information. see product label Please to change. are subject values and ingredients Product nutrient 1 2210 5.1 5.1 25 0.22 0.22 1.1 2210 5.5 5.5 27 3.2 3.2 15.5 9292 92 92 450 450 92 92 450 14.3 14.3 70 78 78 380 10.6 10.6 52 85 85 2.1 390 390 1900 920 920 4500 184 184 900 800 800 3900 (3.3 fl oz) (3.3 fl Powder (490 Cal) oz) (3.3 fl Powder (490 Cal) (mOsm/100 Calories) mcg

), mcg

2 g mcg ),

, 1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B

(% Calories) mcg g mcg

, , , avin avin g

(% Calories) , Linoleic acid Fat Riboﬂ Vitamin B Pantothenic acid Biotin Vitamin B Niacin Folic acid Vitamin A Vitamin D Carbohydrate Nutrients Vitamins/Other Vitamin E Vitamin K Thiamin Potential Renal Solute Load Nutrient DensityProtein 30 Calories/ﬂ NUTRIENT FACTS Water Protein equivalent Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS Fat Carbohydrate WARNING: Not for parenteral (I.V.) use. Product Forms ™ PurAmino Jr is available in powder. For ordering information, please refer Reference to page 301. 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11–14.

Composition Ingredients: Corn syrup solids (47%), amino acids (potassium aspartate, L-leucine, L-lysine hydrochloride, L-proline, L-alanine, L-valine, L-isoleucine, L-threonine, L-serine, L-glutamine, L-tyrosine, L-aspartic acid, L-arginine, L-phenylalanine, L-histidine, L-cystine, glycine, L-tryptophan, L-methionine) (19%), high oleic sunfl ower oil (9%), medium chain triglycerides (MCT oil) (8%), soy oil (8%), modifi ed tapioca starch (3%), calcium phosphate (2%) and less than 2%: sodium citrate, potassium citrate, magnesium phosphate, ferrous sulfate, sodium chloride, zinc sulfate, manganese sulfate, cupric sulfate, sodium iodide, sodium molybdate, sodium selenite, chromic chloride, choline chloride, Schizochytrium sp. oil‡, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, ribofl avin, folic acid, vitamin K1, biotin, vitamin D3, vitamin B12, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.

‡ A source of docosahexaenoic acid (DHA).

Potential Allergens PurAmino Jr contains soy oil. PurAmino Jr is hypoallergenic.

92 PurAmino

Notes

™

93 When PurAmino Jr Vanilla is used as a milk substitute, the total calcium content of the diet should be assessed. ™ PurAmino Jr Extended use of PurAmino Jr Vanilla (or other medical foods for children) is most appropriately monitored by physicians and nutritionists on a Vanilla case-by-case basis.

Description/Indication Product Features • Hypoallergenic, 100% free amino acids as nitrogen source PurAmino Jr Vanilla is a 30 Cal/fl oz, iron-fortifi ed, hypoallergenic, amino acid-based medical food for the dietary management of children • The only amino acid product for one year and up that has DHA, with severe cow’s milk protein allergy, not effectively managed by an an important nutrient that helps support brain and eye development extensively hydrolyzed formula. PurAmino Jr Vanilla is also indicated for • Formulated with 33% medium-chain triglycerides (MCT) oil to help the dietary management of children with multiple food protein allergies. facilitate fat absorption It may also be suitable for conditions requiring an elemental diet such • Has calcium and protein for growing children as protein maldigestion, malabsorption, short bowel syndrome and • Vanilla* fl avor designed to appeal to children’s tastes eosinophilic esophagitis. • Nutritionally complete† Long-Term Usage: PurAmino Jr Vanilla is designed to provide a major • Lactose-free source of nutrition for children age 1 year and up. In cases of severe and • No artifi cial colors or sweeteners multiple food allergies or intolerances, PurAmino Jr Vanilla is sometimes • Non-GMO‡ continued as a milk substitute in the diet of children. This and similar • Kosher, Halal supplemental use of PurAmino Jr Vanilla in the diet may make an important contribution in supporting the maintenance of adequate nutrition in such patients. * Artifi cial fl avor. † Dietary reference intakes include a recommendation for fi ber for >12 months of age. ‡ Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

94 PurAmino™ Jr Vanilla 95 oz Yes 29 540 630 1 32.84.1 3 2.8 4.1 14.5 13.5 20 1.730.82 1.73 0.82 8.5 4 30 30 145 15.3 15.3 75 4310.2 43 10.2 210 50 5161 51 61 250 300 9215.3 92 15.3 450 75 16.3 16.3 80 153 153 750 133 133131 650 131 640 (mOsm/100 mL) mg

mg , mcg , mg mcg

, (mOsm/L) , mg , (mOsm/kg water)

mcg , , mcg , (Ascorbic acid), (Ascorbic

mg , mg

mg mg mcg ,

, , mcg , ,

, mg mg

, , Lactose-free Potential Renal Solute Load Osmolality Osmolarity Choline Copper Iodine Potassium Chloride Chromium Selenium Molybdenum Sodium Magnesium Iron Phosphorus Inositol Minerals Calcium Zinc Manganese Vitamin C Vitamin oz 30 Calories/fl 29 13 45 42 for current information. see product label Please to change. are subject values and ingredients Product nutrient 1 2210 5.1 5.1 25 0.22 0.22 1.1 2210 5.5 5.5 27 3.2 3.2 15.5 9292 92 92 450 450 92 92 450 14.3 14.3 70 78 78 380 10.6 10.6 52 85 85 2.1 390 390 1900 920 920 4500 184 184 900 780 800 3900 (3.3 fl oz) (3.3 fl Powder (490 Cal) oz) (3.3 fl Powder (490 Cal) (mOsm/100 Calories) mcg

), mcg

2 g mcg ),

, 1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B

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(% Calories) , Linoleic acid Fat Riboﬂ Vitamin B Pantothenic acid Biotin Vitamin B Niacin Folic acid Vitamin A Vitamin D Carbohydrate Nutrients Vitamins/Other Vitamin E Vitamin K Thiamin Potential Renal Solute Load Nutrient DensityProtein 30 Calories/ﬂ NUTRIENT FACTS Water Protein equivalent Protein (Normal Dilution) Calories Per 100 mL Per 100 Per 100 grams Per 100 Calories Per 100 mL grams Per 100 NUTRIENTS Fat Carbohydrate WARNING: Not for parenteral (I.V.) use. Product Forms ™ PurAmino Jr Vanilla is available in powder. For ordering information, Reference please refer to page 301. 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11–14.

Composition Ingredients: Corn syrup solids (47%), amino acids (potassium aspartate, L-leucine, L-lysine hydrochloride, L-proline, L-alanine, L-valine, L-isoleucine, L-threonine, L-serine, L-glutamine, L-tyrosine, L-aspartic acid, L-arginine, L-phenylalanine, L-histidine, L-cystine, glycine, L-tryptophan, L-methionine) (19%), high oleic sunfl ower oil (9%), medium chain triglycerides (MCT oil) (8%), soy oil (8%), modifi ed tapioca starch (3%), calcium phosphate (2%) and less than 2%: sodium citrate, potassium citrate, magnesium phosphate, ferrous sulfate, sodium chloride, zinc sulfate, manganese sulfate, cupric sulfate, sodium iodide, sodium molybdate, sodium selenite, chromic chloride, choline chloride, Schizochytrium sp. oil§, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, ribofl avin, folic acid, vitamin K1, biotin, vitamin D3, vitamin B12, vitamin E acetate, artifi cial fl avor, vitamin A palmitate, taurine, L-carnitine.

§ A source of docosahexaenoic acid (DHA).

Potential Allergens PurAmino Jr Vanilla contains soy oil. PurAmino Jr Vanilla is hypoallergenic.

96 Other Special Needs Formulas Extended use of Pregestimil (or other infant formulas) as a sole source of diet is most appropriately monitored by physicians and nutritionists on a Pregestimil® case-by-case basis.

Product Features • Hypoallergenic protein source (extensively hydrolyzed casein) Description/Indication • 55% of the fat from medium-chain triglycerides (MCT) oil Pregestimil is an infant formula designed for infants who experience • Designed for infants with fat malabsorption problems fat malabsorption and who may also be sensitive to intact proteins. • Ready to use is virtually isotonic Fat malabsorption or steatorrhea may be associated with cystic ﬁ brosis, • DHA and ARA, important nutrients also found in breast milk, short bowel syndrome, intractable diarrhea and severe protein calorie that promote brain and eye development1-8 malnutrition. • Available in both powder and Nursette® bottles Long-Term Usage: Pregestimil is designed to provide a sole source of • Lactose-free nutrition for infants up to age 6 months, and to provide a major source of nutrition through 12 months of age. Normally, in feeding infants, gradual introduction of solid foods after 4–6 months of age is an important developmental as well as nutritional step. Product Forms Pregestimil is available in powder and ready-to-use liquid. For ordering In cases of chronic malabsorption disorders, Pregestimil is sometimes information, please refer to page 301. continued as a milk substitute in the diet of children. This and similar supplemental use of Pregestimil in the diet beyond 12 months of age may make a signiﬁ cant contribution to the maintenance of good nutrition in such patients, and is not known to be harmful in any way. When Pregestimil is used as a milk substitute, the total calcium content of the diet should be assessed.

98 Pregestimil® 99 Powder (500 Cal) Per 100 grams Per 100 mL 6.51.460.81 40 2.3 9 5 14 2.34.58.3 14 28 3.2 51 9.70.24 20 60 2.49.7 1.5 15 60 oz 13.87642 85 2061 470 12.2 260 388970 125 380 75 240 550 430 41657349 250 13 400 450 300 19.5 80 120 760280 4700 1750 810 5000 oz) (4.2 ﬂ Per 100 Calories 8 1.8 1 2.8 2.8 5.6 4 0.3 3 17 94 52 25 75 15 47 86 10.2 50 12 80 90 60 16 12 24 10890 2.6 500 410 2500 110 940 350 1000

1.893.86.9 1.89 3.8 6.9 640 640 340 340 oz 24 Cal/ﬂ Product nutrient values and ingredients are subject to change. Please see product label for current information. current label for product Please see to change. subject are ingredients values and nutrient Product 20 Cal/ﬂ oz) Per 100 mL 0.3 0.3 0.2 0.2 60 60 41 41 80 80 54 54 90 90 61 61 2.85.6 2.8 5.6 10.2 10.2 133 131 90 89 940 940 Ready-to-Use Powder Ready-to-Use Powder Ready-to-Use 3322 82.8 8 2.8 5.4 1.89 5.4 1.89 4 4 2.7 2.7 350 350 240 240 1.81 1.8 1 1.22 0.68 1.22 0.68 50 5016 34 16 34 10.8 10.8 75 75 51 51 9452 94 5286 64 35 86 64 35 58 58 15 15 10.1 10.1 17 17 11.5 11.5 12 12 8.1 8.1 25 25 16.9 16.9 47 47 32 32 24 24 16.2 16.2 12 12 8.1 8.1 500 500 110 110 74 74 1000 1000 680 680 mcg

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Iron Zinc Manganese Sodium Fat Linoleic acid Water Vitamin K Thiamin Niacin Vitamin C Choline NUTRIENT FACTS Nutrient Density 20 Cal/fl oz 24 Cal/fl oz 20 Cal/fl oz 24 Cal/fl oz Pwd Liq Protein (% Calories) 11 11 Potential Renal Solute Load (mOsm/100 mL)9 16.9 16.9 20 Fat (% Calories) 49 49 Osmolality (mOsm/kg water) 320 290 340 Carbohydrate (% Calories) 40 40 Osmolarity (mOsm/L) 280 260 310 Potential Renal Solute Load (mOsm/100 Calories)9 25 25 Lactose-free Yes Yes Yes

Composition biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium hydroxide, calcium phosphate, potassium phosphate, magnesium Ingredients: Powder: Corn syrup solids (42%), casein hydrolysate* (from chloride, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, milk) (16%), medium chain triglycerides (MCT oil) (15%), modifi ed corn sodium citrate, sodium iodide, potassium citrate, sodium selenite, starch (7%), soy oil (7%), corn oil (2%), high oleic vegetable oil (saffl ower or potassium chloride, L-cystine, L-tyrosine, L-tryptophan, taurine, L-carnitine. sunfl ower) (2%) and less than 2%: Mortierella alpina oil†, Crypthecodinium ‡ Ingredients: 24 Calories/fl oz Ready To Use: Water (84%), corn syrup cohnii oil , vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, solids (6%), casein hydrolysate* (milk) (3%), medium chain triglycerides thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline (MCT oil) (2%), soy oil (2%), modifi ed corn starch (2%) and less than 2%: † chloride, inositol, calcium citrate, calcium phosphate, magnesium oxide, high oleic vegetable oil (saffl ower or sunfl ower oil), Mortierella alpina oil , ‡ ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium Crypthecodinium cohnii oil , calcium phosphate, potassium citrate, calcium iodide, sodium citrate, potassium citrate, potassium chloride, potassium carbonate, magnesium chloride, potassium phosphate, calcium hydroxide, hydroxide, sodium selenite, L-cystine, L-tyrosine, L-tryptophan, taurine, potassium chloride, sodium citrate, ferrous sulfate, zinc sulfate, cupric L-carnitine. sulfate, manganese sulfate, sodium iodide, sodium selenite, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, Ingredients: 20 Calories/fl oz Ready To Use: Water (87%), corn syrup solids vitamin B12, thiamin hydrochloride, vitamin D3, ribofl avin, vitamin B6 (5%), casein hydrolysate* (milk) (2%), medium chain triglycerides (MCT oil) hydrochloride, folic acid, vitamin K1, biotin, carrageenan, choline chloride, (2%) and less than 2%: modifi ed corn starch, soy oil, high oleic vegetable oil inositol, L-cystine, L-tyrosine, L-tryptophan, taurine, L-carnitine. (saffl ower and/or sunfl ower oils), Mortierella alpina † ‡ oil , Crypthecodinium cohnii oil , carrageenan, vitamin A palmitate, vitamin * Modifi ed to be better tolerated in milk-allergic babies. D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, ribofl avin, vitamin † A source of arachidonic acid (ARA). B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, ‡ A source of docosahexaenoic acid (DHA). 100 Pregestimil® 101 . . J Pediatr Dev Med J Pediatr Am J Clin Nutr . 1998;44:201-209. . . 2005;81:197-203. . Pediatr Res Pediatr Early Hum Dev . 2003;142:669-677. . J Pediatr . 2002;75:570-580. . . 2000;31:540-553. . . 2000;42:174-181. . . 2003;17:A727-A728. Abstract 445.1. 2003;17:A727-A728. . Am J Clin Nutr acid and arachidonic acid in the diet of term infants. the diet of term infants. arachidonic acid in acid and of long-chain polyunsaturated fatty infants. and mental development in term acids Child Neurol polyunsaturated fatty acid supplementation after weaning at of formula in term infants 6 wk of age. receiving dietary18-month old infants polyunsaturated long-chain fatty acids [abstract]. J FASEB a polyunsaturatesweaned to formula with or without long-chain at 4 to 6 months: trial. randomized clinical composition of long-chain polyunsaturated fatty acids on later visual development. Gastroenterol Nutr polyunsaturated fatty acid-supplemented or control formula for 12 mo. polyunsaturated fatty acid-supplemented or control formula for 12 mo. 2005;81:871-879. acids availability in the diet and visual acuity. acids availability visual acuity. in the diet and 1999;134:11-14. Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic acuity and the Visual al. et Uauy R, Hoffman DR, EE, Birch Maturation of visual and mental function in et al. YS, Castañeda EE, Birch Hoffman DR, Birch EE, Garfi eld S, Hoffman DR, et al. A randomized controlled trial of early dietaryA randomized controlled trial of supply et al. Hoffman DR, S, eld Garfi Birch EE, controlled trial of long-chainA randomized et al. YS, Castañeda DR, Hoffman Birch EE, Visual function in breast-fed term infants et al. YS, Castañeda Birch EE, Hoffman DR, Impact of early dietary intake and blood lipid et al. Birch DG, Birch EE, Hoffman DR, Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturationVisual of term infants fed long-chain et al. Wheaton DH, YS, Castañeda Birch EE, Morale SE, Hoffman DR, Castañeda YS, et al. Duration of long-chain polyunsaturated fatty et al. YS, Castañeda Hoffman DR, Morale SE, Fomon SJ, Ziegler EE. Renal solute and potential renal solute load in infancy. and potential renal solute load in infancy. Renal solute Ziegler EE. SJ, Fomon 1. 4. 2. 3. 5. 6. References 7. 8. 9.

contains milk and soy. Pregestimil is hypoallergenic. is hypoallergenic. Pregestimil milk and soy. contains ®

Pregestimil Potential Allergens Potential formulas have reported. been Rarely, however, allergic reactions to extensively hydrolyzed casein to extensively hydrolyzed allergic reactions however, Rarely, Product Form ™ Enfaport is available in ready-to-use liquid. For ordering information, Enfaport please refer to page 300.

Composition Description/Indication Ingredients: Ready to Use: Nonfat milk, water, corn syrup solids, medium chain triglycerides (MCT oil), whey protein concentrate and Enfaport is designed to meet the unique nutritional needs of infants with less than 2%: Mortierella alpina oil‡, Crypthecodinium cohnii oil§, soy oil, chylothorax or LCHAD deﬁ ciency. Enfaport balances high levels of medium- calcium carbonate, potassium chloride, magnesium chloride, magnesium chain triglycerides (MCT) oil for easier absorption, and has DHA and ARA, phosphate, potassium phosphate, ferrous sulfate, calcium chloride, important fatty acids for infant development. sodium chloride, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, vitamin D3, thiamin hydrochloride, vitamin B6 hydrochloride, riboﬂ avin, folic acid, vitamin K1, Product Features biotin, vitamin B12, choline chloride, inositol, carrageenan, mono- and • Easy-to-digest 60:40 whey-to-casein ratio, patterned after mature diglycerides, taurine, L-carnitine. breast milk1,* • 83% MCT† oil for easier fat absorption ‡ A source of arachidonic acid (ARA). • DHA and ARA, important nutrients also found in breast milk that § A source of docosahexaenoic acid (DHA). promote brain and eye development2-9 • Kosher Potential Allergens Enfaport contains milk and soy. * Comparison based on whey-to-casein ratio of typical mature breast milk (15 days to 6 months after birth). † % of total fat blend.

102 Enfaport™ 103 Per 100 mL Per 100 oz No 29 360 310 8.8 9 1.8 1.83 1 1.02 3 3.1 2.8 2.9 9452 96 53 17 17.3 1224 12.2 24 2575 25 76 15 15.3 30 31 87 89 (3.3 ﬂ oz) (3.3 ﬂ 115 117 10 Per 100 Calories Per 100 (mOsm/100 mL) mg

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, , Iron Magnesium Minerals Calcium Phosphorus Zinc Vitamin C Choline Inositol Biotin Manganese Copper Iodine Selenium Sodium Potassium Chloride Osmolality Osmolarity Lactose-free Potential Renal Solute Load oz 30 Cal/fl 46 40 28 14 Per 100 mL Per 100 label for current information. see product Please to change. and ingredients are subject values Product nutrient 4 4.1 5.5 5.6 3.5 3.6 0.3 0.31 50 51 83 85 12 12.2 10 10.2 8090 81 92 68 69 16 16.3 10 (3.3 fl oz) (3.3 fl 350 360 350 360 500 510 1000 1020 Per 100 Calories Per 100 (mOsm/100 Calories) mcg

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, (% Calories) Vitamin E Vitamin A Vitamin D Vitamins/Other Nutrients Vitamins/Other Vitamin K Water Linoleic acid Carbohydrate Carbohydrate Carbohydrate Potential Renal Solute Load Thiamin Fat Fat Protein NUTRIENT FACTS Nutrient Density 30 Cal/fl Protein (Normal Dilution) NUTRIENTS Ribofl Vitamin B Niacin Vitamin B Folic acid Pantothenic acid References 1. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 6. Hoffman DR, Birch EE, Castañeda YS, et al. Maturation of visual and mental function in 18-month- 1992;81:107-112. old infants receiving dietary long-chain polyunsaturated fatty acids (LCPUFAs) [abstract]. FASEB J. 2. Birch EE, Hoffman DR, Uauy R et al. Visual acuity and the essentiality of docosahexaenoic acid 2003;17:A727-A728. Abstract 445.1. and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201-209. 7. Hoffman DR, Birch EE, Birch DG, et al. Impact of early dietary intake and blood lipid composition 3. Birch EE, Garfi eld S, Hoffman DR, et al. A randomized controlled trial of early dietary supply of of long-chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Nutr. 2000;31:540-553. Neurol. 2000;42:174-181. 8. Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturation of term infants fed long-chain 4. Birch EE, Hoffman DR, Castañeda YS, et al. A randomized controlled trial of long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mos. Am J Clin Nutr. polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of 2005;81:871-879. age. Am J Clin Nutr. 2002;75:570-580. 9. Morale SE, Hoffman DR, Castañeda YS, et al. Duration of long-chain polyunsaturated fatty acids 5. Hoffman DR, Birch EE, Castañeda YS, et al. Visual function in breast-fed term infants weaned to availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203. formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. J 10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. Pediatr. 2003;142:669-677. 1999;134:11-14.

104 Enfaport

Notes

™

105 Product Form Portagen is available in powder. For ordering information, please refer to ® Portagen page 301.

Composition Ingredients: Corn syrup solids, medium chain triglycerides (MCT oil), Description/Indication sodium caseinate (milk), sugar, corn oil and less than 2%: calcium citrate, Portagen is a milk protein-based powder with medium-chain triglycerides potassium chloride, magnesium phosphate, calcium phosphate, potassium (MCT) for children and adults with defects in the intraluminal hydrolysis of citrate, sodium citrate, ferrous sulfate, zinc sulfate, cupric sulfate, fat (decreased pancreatic lipase, decreased bile salts); defective mucosal manganese sulfate, sodium iodide, soy lecithin, ascorbic acid, niacinamide, fat absorption (decreased mucosal permeability, decreased absorptive calcium pantothenate, riboﬂ avin, vitamin B6 hydrochloride, vitamin D3, surface); and/or defective lymphatic transport of fat (ie, intestinal thiamin hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, choline lymphatic obstruction). chloride, vitamin E acetate, taurine, inositol, vitamin A palmitate, L-carnitine.

Portagen is not recommended for use as an infant formula.

Long-Term Usage: Portagen powder is not nutritionally complete. If used Potential Allergens long term, supplementation of essential fatty acids and ultra-trace minerals Portagen contains milk protein. should be considered.

CAUTION: Use as directed by your physician or dietitian. Portagen powder is not designed for use as an infant formula. Product Features WARNING: Not for parenteral (I.V.) use. • 87% of fat from MCT • Corn oil provides linoleic acid References • Kosher 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

106 Portagen® ‡ 107 % RDI (per quart) oz Yes 840 178:1 153:1 per quart (30 Calories/ﬂ oz) (30 Calories/ﬂ Prepared Beverage Prepared Suitable for someone with lactose intolerance 0.74 1.51 100 0.59 1.2 60 0.74 1.51 80 4.4 9 60 0.889.8 1.79 204.9 110 8.8 100 10 17.9 100 100 0.98 2 100 2.9 5.9 100 74 151 190 3498 69 200 45 50 7437 151 75 40 25 Per 100 440330 900 670 90 70 grams Powder mg

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, , Thiamin Vitamin K Manganese Copper Zinc Pantothenic acid Calcium Iron Phosphorus Iodine Magnesium Ribofl Niacin Vitamin B Folic acid Vitamin B Biotin Water Water Total Calorie:Nitrogen Ratio Total Nonprotein Calorie:Nitrogen Ratio Lactose-free Low-residue † † † † † † † † † † % RDI oz 30 Calories/fl (per quart) 46 14 40 300 350 290 30 100 per quart 3300 (30 Calories/fl oz) (30 Calories/fl Prepared Beverage Prepared 1

22 45 16.5 34 68* 54 110 28 57 14.7 38 77 130 6122 124 45 <5 8 Per 100 470 960 590 1200 370 750 190 260410 530 830 1300 2600 3700 7500 150 grams Powder (mOsm/L) Please see product label for current information. change. Product nutrient values and ingredients are subject to g

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(% Calories) , Fat Protein Cholesterol Carbohydrate Calories (Normal Dilution) NUTRIENTS Vitamin E Vitamin D Choline Taurine Inositol Vitamins and Vitamin A Vitamin C Sodium Chloride Linoleic acid Potassium Potential Renal Solute Load Fat Carbohydrate Osmolality Nutrient DensityProtein 30 Calories/ﬂ NUTRIENT FACTS Osmolarity * (DV). Value Daily Percent Reference Daily Intake (RDI) not established. † Not suitable for persons with galactosemia. ‡ Product Form 3232 A is available in powder. For ordering information, please refer to 3232 A page 296.

Composition Ingredients: Modifi ed tapioca starch (34%), medium chain triglycerides Description/Indication (MCT oil) (28%), casein hydrolysate* (milk) (26%), corn oil (6%) and less 3232 A is a protein hydrolysate base powder that is to be used with than 2%: vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, added carbohydrate. It contains tapioca starch. It is for use in the dietary thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin B12, management of infants and children with disaccharidase defi ciencies niacinamide, folic acid, calcium pantothenate, biotin, sodium ascorbate, or other disorders of carbohydrate metabolism under the direct and choline chloride, inositol, calcium citrate, calcium hydroxide, calcium continuing supervision of a doctor. phosphate, magnesium oxide, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium chloride, sodium iodide, potassium citrate, Long-Term Usage: 3232 A is not nutritionally complete. Care should potassium phosphate, soy lecithin, calcium chloride, potassium chloride, be taken to ensure adequate carbohydrate is added. If used long term, sodium selenite, L-cystine, L-tyrosine, L-tryptophan, taurine, L-carnitine. additional essential fatty acids should be considered. To be used only under the supervision of a doctor. * Modifi ed to be better tolerated in milk-allergic babies.

Product Features Potential Allergens • Allows adjustment of added carbohydrate according to patient’s tolerance 3232 A contains milk and soy. 3232 A is hypoallergenic. Allergic reactions to extensively hydrolyzed casein formulas are not commonly reported. • Hypoallergenic, protein hydrolysate • 82% of the fat from medium-chain triglycerides (MCT) oil

108 3232 A ‡ 109 (500 Cal) Per 100 g Powder Per 100 † 7.8 61 4.7 37 755 2.8 22 1.5 11.8 0.62 4.9 65 510 3285 250 670 10.9 86 62 490 94 740 43 340 11.713.3 92 105 (5 ﬂ oz) (5 ﬂ 109 860 Per 100 Calories Per 100 mg

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, , Chloride Biotin Manganese Copper Iron Magnesium Phosphorus Potassium Minerals Calcium Sodium Inositol Selenium Vitamin C Iodine Choline Zinc ‡ (500 Cal) Per 100 g Powder Per 100 † 3.8 30 0.32 2.5 4.2 33 2.8 22 (5 ﬂ oz) (5 ﬂ 77 610 94 740 60 470 15.6 123 62 490 13.4 33 18.8 148 470 3700 380 3000 300 2400 132 3 1000 7900 Per 100 Calories Per 100 for current information. Please see product label change. and ingredients are subject to Product nutrient values mcg

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, Fat Ribofl Vitamin B Vitamin E Vitamin D Vitamin A Folic acid Pantothenic acid Linoleic acid Vitamin B Niacin Carbohydrate Water Protein (Normal Dilution) NUTRIENTS Vitamin K Vitamins/Other Nutrients Thiamin Product is incomplete without the addition of carbohydrate. A and 59 grams of carbohydrate per quart of prepared product. Using 81 grams of 3232 † added carbohydrate. do not include Values ‡ cient carbohydrates. fattyCare must be taken to provide essential acids and suffi § NUTRIENT FACTS Prepared with 59 g added Prepared with no carbohydrate Nutrient Density carbohydrate at 20 Cal/fl oz at 12.7 Cal/fl oz Protein (% Calories) 11 18 Fat (% Calories) 35 56 Carbohydrate (% Calories) 54 26 Potential Renal Solute Load (mOsm/100 Calories)1 25 39 Potential Renal Solute Load (mOsm/100 mL)1 16.5 16.5 Lactose-free Suitable for lactose intolerance if no lactose is added

CAUTION References WARNING: This product is nutritionally incomplete. Care must be taken 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. to provide enough carbohydrate to support growth, using other foods with 3232 A as required. For long-term use, additional essential fatty acids should be considered. The child’s doctor must carefully and constantly supervise use of 3232 A. WARNING: Not for parenteral (I.V.) use.

110 Premature Infant Formulas and Products 1-3 ® • 3.3 g of protein/100 Calories—appropriate for growth and development Enfamil • 80:20 whey-to-casein ratio patterned after early human milk† Premature • Calcium, phosphorus and vitamin D within the ranges recommended by experts to help support bone mineralization and growth1: 20 Cal ° Calcium:phosphorus ratio = 1.83:1 • DHA at 0.34% of total fatty acids, similar to the worldwide breast milk average4,‡, to help support brain and eye development and to help support blood DHA concentration5 Description/Indication • Fat blend is 40% medium-chain triglycerides (MCT) oil to promote Enfamil Premature 20 Cal is a milk-based infant formula speciﬁ cally fat absorption6,7 formulated to meet the unique nutritional needs of rapidly growing • Carbohydrate blend of 60% corn syrup solids (glucose polymers) and premature or low-birth-weight infants who do not receive human milk*. 40% lactose that is easily digested and helps avoid overloading the The Enfamil Premature Nutrition portfolio is the only premature infant premature infant's capacity to digest lactose formula line designed to meet the latest Global Expert Recommendations • Provides approximately 2 mg iron/kg body weight when fed at for all labeled nutrients. Protein is a major driver of lean mass growth and 120 Cal/kg body weight per day neuro-cognitive outcomes, and Enfamil Premature Nutrition supports these • Kosher, Halal protein needs.

* Increased caloric density, protein, and some vitamins and minerals compared to standard term When more than 14 ﬂ oz (414 mL) of 20 Calories/ﬂ oz product is used formula to help support weight and growth in babies born prematurely. per day, which may occur in larger infants weighing over 2500 g (5.5 lbs) † Whey-to-casein ratio 3-5 days after lactation begins. consuming only Enfamil Premature, intake of some nutrients (eg, fat soluble ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of 4 vitamins) may be excessive. In such circumstances, it should be used only total fatty acids) based on an analysis of 65 studies of 2,474 women . at the direction and under the supervision of a doctor. Enfamil® EnfaCare® may be a product to consider in such circumstances.

Product Features • Meets 2014 Global Expert Recommendations for 100% of all labeled nutrients1 112 Enfamil® Premature 20 Cal 113 oz 20 No 260 230 1.5 1.01 91.8 6.1 1.22 4 2.7 6.3 4.3 5 3.4 90 61 44 30 24 16.2 98 66 20 13.5 70 47 25 16.9 165 112 106 72 120 81 8 (mOsm/100 mL) mg

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(% Calories) , Thiamin Vitamin E Vitamin K Vitamin D Vitamin A Water Nutrients Vitamins/Other Carbohydrate Pantothenic acid Linoleic acid Folic acid Fat Riboﬂ Niacin Vitamin B Fat Carbohydrate Potential Renal Solute Load Whey:Casein Ratio Vitamin B Protein NUTRIENT FACTS Nutrient Density 20 Calories/ﬂ Protein (Normal Dilution) Per 100 Calories Per 100 mL Per 100 Calories Per 100 mL NUTRIENTS Product Forms Potential Allergens Enfamil® Premature 20 Cal is available in ready-to-use Nursette® bottles. Enfamil Premature 20 Cal contains milk and soy. For ordering information, please refer to page 299. CAUTION This product should be used only as directed by the baby’s doctor.

Composition Ingredients: Ready To Use (2 fl oz Nursette bottles): Water, nonfat milk, corn syrup solids, whey protein concentrate, lactose, medium chain References 1. Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientifi c Basis and triglycerides (MCT oil), soy oil, high oleic sunfl ower oil and less than 0.5%: Practice Guidelines. World Rev Nutr Diet. Basel, Karger, 2014; 110:1-314. § || Mortierella alpina oil , Crypthecodinium cohnii oil , calcium phosphate, 2. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132(suppl):1395S- calcium hydroxide, potassium citrate, sodium chloride, calcium carbonate, 1577S. magnesium phosphate, calcium chloride, potassium chloride, ferrous 3. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85-91. rice starch, sodium ascorbate, vitamin E acetate, niacinamide, calcium 4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in pantothenate, vitamin A palmitate, thiamin hydrochloride, ribofl avin, vitamin human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 5. Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, mono- and with no adverse effects in preterm infants fed formula. J Pediatr. 2002;140:547-554. diglycerides, inositol, soy lecithin, choline chloride, vitamin D3, nucleotides 6. Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, on fat and nitrogen absorption. Pediatrics. 1975;55:359-370. adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), 7. Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain triglyceride containing formula [abstract]. Pediatr Res. 1974;8:104. taurine, L-carnitine. 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. § A source of arachidonic acid (ARA). || A source of docosahexaenoic acid (DHA).

114 Enfamil

Notes

® Premature 20 Cal

115 1-3 ® • 3.3 g of protein/100 Calories—appropriate for growth and development Enfamil • 80:20 whey-to-casein ratio patterned after early human milk† Premature • Calcium, phosphorus and vitamin D within the ranges recommended by experts to help support bone mineralization and growth1: 24 Cal ° Calcium:phosphorus ratio = 1.83:1 • DHA at 0.34% of total fatty acids, similar to the worldwide breast milk average4,‡, to help support brain and eye development and to help support blood DHA concentration5 Description/Indication • Fat blend is 40% medium-chain triglycerides (MCT) oil to promote Enfamil Premature 24 Cal is a milk-based infant formula speciﬁ cally fat absorption6,7 formulated to meet the unique nutritional needs of rapidly growing • Carbohydrate blend of 60% corn syrup solids (glucose polymers) and premature or low-birth-weight infants who do not receive human milk*. 40% lactose that is easily digested and helps avoid overloading the The Enfamil Premature Nutrition portfolio is the only premature infant premature infant's capacity to digest lactose formula line designed to meet the latest Global Expert Recommendations • Provides approximately 2 mg iron/kg body weight when fed at for all labeled nutrients. Protein is a major driver of lean mass growth and 120 Cal/kg body weight per day neuro-cognitive outcomes, and Enfamil Premature Nutrition supports these • Kosher, Halal protein needs.

* Increased caloric density, protein, and some vitamins and minerals compared to standard term When more than 12 ﬂ oz (355 mL) of 24 Calories/ﬂ oz product is used formula to help support weight and growth in babies born prematurely. per day, which may occur in larger infants weighing over 2500 g (5.5 lbs) † Whey-to-casein ratio 3-5 days after lactation begins. consuming only Enfamil Premature, intake of some nutrients (eg, fat soluble ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of 4 vitamins) may be excessive. In such circumstances, it should be used only total fatty acids) based on an analysis of 65 studies of 2,474 women . at the direction and under the supervision of a doctor. Enfamil® EnfaCare® may be a product to consider in such circumstances.

Product Features • Meets 2014 Global Expert Recommendations for 100% of all labeled nutrients1 116 Enfamil® Premature 24 Cal 117 oz 25 No 320 280 1.5 1.22 9 7.3 1.8 1.46 6.3 5.1 5 4.1 4 3.2 90 73 44 36 98 80 24 19.5 70 57 20 16.2 25 20 165 134 106 86 120 97 8 (mOsm/100 mL) mg

mg mg mcg

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), mcg

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(% Calories) mg ,

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(% Calories) , Thiamin Vitamin E Vitamin K Vitamin A Vitamin D Vitamins/Other Nutrients Vitamins/Other Water Pantothenic acid Carbohydrate Folic acid Linoleic acid Vitamin B Ribofl Niacin Fat Vitamin B Fat Carbohydrate Potential Renal Solute Load Whey:Casein Ratio Protein NUTRIENT FACTS Nutrient Density 24 Calories/fl Protein (Normal Dilution) Per 100 Calories Per 100 mL Per 100 Calories Per 100 mL NUTRIENTS Product Forms Potential Allergens Enfamil® Premature 24 Cal is available in ready-to-use Nursette® bottles. Enfamil Premature 24 Cal contains milk and soy. For ordering information, please refer to page 299. CAUTION This product should be used only as directed by the baby’s doctor. Composition Ingredients: Ready To Use (2 fl oz Nursette bottles): Water, nonfat milk, References corn syrup solids, whey protein concentrate, lactose, medium chain 1. Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientifi c Basis and triglycerides (MCT oil), soy oil, high oleic sunfl ower oil and less than 0.5%: Practice Guidelines. World Rev Nutr Diet. Basel, Karger, 2014; 110:1-314. Mortierella alpina oil§, Crypthecodinium cohnii oil||, calcium phosphate, 2. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132(suppl):1395S- calcium hydroxide, potassium citrate, sodium chloride, calcium carbonate, 1577S. 3. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: magnesium phosphate, calcium chloride, potassium chloride, ferrous commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85-91. rice starch, sodium ascorbate, vitamin E acetate, niacinamide, calcium 4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. pantothenate, vitamin A palmitate, thiamin hydrochloride, ribofl avin, vitamin 5. Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, mono- and with no adverse effects in preterm infants fed formula. J Pediatr. 2002;140:547-554. diglycerides, inositol, soy lecithin, choline chloride, vitamin D3, nucleotides 6. Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, on fat and nitrogen absorption. Pediatrics. 1975;55:359-370. 7. Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), triglyceride containing formula [abstract]. Pediatr Res. 1974;8:104. taurine, L-carnitine. 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. § A source of arachidonic acid (ARA). || A source of docosahexaenoic acid (DHA).

118 Enfamil

Notes

® Premature 24 Cal

119 • 3.6 g of protein/100 Calories—appropriate for growth and development1-3 ® Enfamil • 80:20 whey-to-casein ratio patterned after early human milk† Premature • Calcium, phosphorus and vitamin D within the ranges recommended by experts to help support bone mineralization and growth1: 24 Cal HP ° Calcium:phosphorus ratio = 1.83:1 • DHA at 0.34% of total fatty acids, similar to the worldwide breast milk average4,‡, to help support brain and eye development and to help support blood DHA concentration5 Description/Indication • Fat blend is 40% medium-chain triglycerides (MCT) oil to promote fat Enfamil Premature 24 Cal High Protein (HP) is a milk-based infant formula absorption6,7 speciﬁ cally formulated to meet the unique nutritional needs of rapidly • Carbohydrate blend of 60% corn syrup solids (glucose polymers) and growing premature or low-birth-weight infants who do not receive human 40% lactose that is easily digested and helps avoid overloading the milk*. The Enfamil Premature Nutrition portfolio is the only premature infant premature infant’s capacity to digest lactose formula line designed to meet the latest Global Expert Recommendations • Provides approximately 2 mg iron/kg body weight when fed at for all labeled nutrients. Protein is a major driver of lean mass growth and 120 Cal/kg body weight per day neuro-cognitive outcomes, and Enfamil Premature Nutrition supports these • Kosher, Halal protein needs.

Product Features • Meets 2014 Global Expert Recommendations for 100% of all labeled nutrients1 120 Enfamil® Premature 24 Cal HP 121 oz 26 No 300 260 1.5 1.22 9 7.3 1.8 1.46 6.3 5.1 5 4.1 4 3.2 90 73 44 36 98 80 24 19.5 70 57 20 16.2 25 20 165 134 106 86 120 97 8 (mOsm/100 mL) mg

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(% Calories) , Thiamin Vitamin E Vitamin K Vitamin A Vitamin D Vitamins/Other Nutrients Vitamins/Other Water Pantothenic acid Carbohydrate Folic acid Linoleic acid Vitamin B Ribofl Niacin Fat Vitamin B Fat Carbohydrate Potential Renal Solute Load Whey:Casein Ratio Protein NUTRIENT FACTS Nutrient Density 24 Calories/fl Protein (Normal Dilution) Per 100 Calories Per 100 mL Per 100 Calories Per 100 mL NUTRIENTS Product Forms Potential Allergens Enfamil® Premature 24 Cal HP is available in ready-to-use Nursette® bottles. Enfamil Premature 24 Cal HP contains milk and soy. For ordering information, please refer to page 299. CAUTION This product should be used only as directed by the baby’s doctor. Composition Ingredients: Ready To Use (2 fl oz Nursette bottles): Water, nonfat milk, corn syrup solids, whey protein concentrate, lactose, medium chain References 1. Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientifi c Basis and triglycerides (MCT oil), soy oil, high oleic sunfl ower oil and less than 0.5%: Practice Guidelines. World Rev Nutr Diet. Basel, Karger, 2014; 110:1-314. § || Mortierella alpina oil , Crypthecodinium cohnii oil , calcium phosphate, 2. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132(suppl):1395S- calcium hydroxide, potassium citrate, sodium chloride, calcium carbonate, 1577S. magnesium phosphate, calcium chloride, sodium citrate, ferrous sulfate, 3. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, sodium Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85-91. ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin 4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. A palmitate, vitamin D3, thiamin hydrochloride, ribofl avin, vitamin B6 5. Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, rice starch, inositol, with no adverse effects in preterm infants fed formula. J Pediatr. 2002;140:547-554. mono- and diglycerides, soy lecithin, choline chloride, nucleotides (cytidine 6. Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects 5’-monophosphate, adenosine 5’-monophosphate, disodium uridine on fat and nitrogen absorption. Pediatrics. 1975;55:359-370. 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, 7. Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain triglyceride containing formula [abstract]. Pediatr Res. 1974;8:104. L-carnitine. 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. § A source of arachidonic acid (ARA). || A source of docosahexaenoic acid (DHA).

122 Enfamil

Notes

® Premature 24 Cal HP

123 Enfamil® Product Features • Meets 2014 Global Expert Recommendations for 100% of all Premature labeled nutrients1 30 Cal • 3.3 g of protein/100 Calories—appropriate for growth and development1-3 • 80:20 whey-to-casein ratio patterned after early human milk† • Calcium, phosphorus and vitamin D within the ranges recommended by experts to help support bone mineralization and growth1: Description/Indication ° Calcium:phosphorus ratio = 1.83:1 Enfamil Premature 30 Cal is a milk-based infant formula speciﬁ cally • DHA at 0.34% of total fatty acids, similar to the worldwide breast milk formulated to meet the unique nutritional needs of rapidly growing average4,‡, to help support brain and eye development and to help premature or low-birth-weight infants who do not receive human milk*. support blood DHA concentration5 The Enfamil Premature Nutrition portfolio is the only premature infant • Fat blend is 40% medium-chain triglycerides (MCT) oil to promote formula line designed to meet the latest Global Expert Recommendations fat absorption6,7 for all labeled nutrients. Protein is a major driver of lean mass growth • Carbohydrate blend of 85% maltodextrin and 15% lactose that is easily and neuro-cognitive outcomes, and Enfamil Premature Nutrition supports digested and helps avoid overloading the premature infant’s capacity these protein needs. to digest lactose • Provides approximately 2 mg iron/kg body weight when fed at Enfamil Premature 30 Cal is a versatile formula. It is ready to use at 120 Cal/kg body weight per day its full concentration for a calorically dense 30 Cal formula or can be customized for infants in the NICU. It can be mixed with Enfamil Premature • Kosher, Halal 24 Cal to attain between 25 and 29 Cal/ﬂ oz, or increase the protein content by mixing with Enfamil Premature 24 Cal HP. * Increased caloric density, protein, and some vitamins and minerals compared to standard term formula to help support weight and growth in babies born prematurely. † Whey-to-casein ratio 3-5 days after lactation begins. Enfamil Premature 30 Cal provides expert nutrition to help meet the needs ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of of your smallest infants. total fatty acids) based on an analysis of 65 studies of 2,474 women4.

124 Enfamil® Premature 30 Cal 125 oz 30 No 320 270 1.5 1.52 1.8 1.83 9 9.1 4 4.1 6.3 6.4 5 5.1 90 91 44 45 24 24 20 20 70 71 98 99 25 25 165 167 106 107 120 122 8 (mOsm/100 mL) mg

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, , Zinc Iron Magnesium Minerals Calcium Phosphorus Inositol Choline Chloride Vitamin C Biotin Manganese Copper Sodium Potassium Selenium Iodine Lactose-free Osmolarity Osmolality Potential Renal Solute Load oz 30 Calories/ﬂ 43 44 13 30 information. product label for current Please see to change. are subject values and ingredients nutrient Product 80:20 9 9.1 6.3 6.4 5 5.1 3.3 3.3 0.25 0.25 83 84 10.8 10.9 40 41 8 300 300 810 820 200300 200 300 150 152 1350 1370 4000 4100 1200 1220 (mOsm/100 Calories) mcg

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(% Calories) , Thiamin Vitamin K Vitamin E Vitamin D Vitamins/Other Nutrients Vitamins/Other Vitamin A Water Carbohydrate Linoleic acid Pantothenic acid Fat Fat Carbohydrate Potential Renal Solute Load Whey:Casein Ratio Ribofl Vitamin B Niacin Folic acid Nutrient DensityProtein 30 Calories/fl NUTRIENT FACTS Protein Vitamin B (Normal Dilution) Per 100 Calories Per 100 mL Per 100 Calories Per 100 mL NUTRIENTS Product Forms Potential Allergens Enfamil® Premature 30 Cal is available in ready-to-use Nursette® bottles. Enfamil Premature 30 Cal contains milk and soy. For ordering information, please refer to page 299. CAUTION This product should be used only as directed by the baby’s doctor. Composition Ingredients: Ready To Use (2 fl oz Nursette bottles): Water, nonfat milk, References maltodextrin, whey protein concentrate, medium chain triglycerides (MCT 1. Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientifi c Basis and oil), soy oil, high oleic sunfl ower oil and less than 1%: Mortierella alpina Practice Guidelines. World Rev Nutr Diet. Basel, Karger, 2014; 110:1-314. oil§, Crypthecodinium cohnii oil||, calcium phosphate, calcium hydroxide, 2. Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr. 2002;132(suppl): potassium citrate, sodium chloride, calcium carbonate, magnesium 1395S-1577S. 3. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: phosphate, potassium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition potassium iodide, sodium selenite, manganese sulfate, sodium ascorbate, Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85-91. vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, 4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. vitamin D3, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, 5. Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth folic acid, vitamin K1, biotin, vitamin B12, mono- and diglycerides, with no adverse effects in preterm infants fed formula. J Pediatr. 2002;140:547-554. inositol, rice starch, soy lecithin, choline chloride, nucleotides (cytidine 6. Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine on fat and nitrogen absorption. Pediatrics. 1975;55:359-370. 7. Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, triglyceride containing formula [abstract]. Pediatr Res. 1974;8:104. L-carnitine. 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. § A source of arachidonic acid (ARA). || A source of docosahexaenoic acid (DHA).

126 Enfamil

Notes

® Premature 30 Cal

127 Enfamil® Premature Caloric Recipes

EnfamilE f il PPremature iis a versatile il fformula l that h can be customized Directions for Use: to help meet the needs of infants in the NICU. By following the recipes Follow the instructions for preparation and use found on product label, provided, Enfamil Premature can be mixed to adjust between 25 and except mix Enfamil Premature formula in the ratios provided on the 29 Cal per ﬂ oz, or the protein content can be increased by mixing with following pages. Enfamil Premature 24 Cal High Protein.

128 Enfamil

Enfamil® Premature 30 Cal + Enfamil® Premature 24 Cal Recipes for various

formula concentrations ® To Prepare Mix the following Premature Caloric Recipes for targeted caloric 25 Cal/ﬂ oz intakes + (See pages 100–114 for nutrient information.)

1 part EP 30 Cal + 5 parts EP 24 Cal

26 Cal/fl oz Always measure + liquid formulas by 1 part EP 30 Cal + 2 parts EP 24 Cal volume when mixing, as bottle fi ll weights 27 Cal/fl oz may vary. +

1 part EP 30 Cal + 1 part EP 24 Cal

28 Cal/ﬂ oz +

2 parts EP 30 Cal + 1 part EP 24 Cal 29 Cal/ﬂ oz +

5 parts EP 30 Cal + 1 part EP 24 Cal

129 ® ® Enfamil Enfamil® Premature Enfamil® Prematuree Enfamil Nutrients per 100 Cal Prematureure Prematureure 24 Cal 30 Cal + 24 Cal 30 Cal Approximate Ratio n/a/ 1:5 1:2 1:1 2:151 5:1 n/a/ Cal/ﬂ oz 24 25 26 27 28 29 30 Calories 100 100 100 100 100 100 100 Volume, mL/100 Cal 123 118 114 109 106 101 99 Protein, g whey:casein ratio=80:20 3.3 3.3 3.3 3.3 3.3 3.3 3.3 Fat,g 5 555555 Carbohydrate,g 10.8 10.8 10.9 10.8 10.8 10.9 10.8 Vitamins Vitamin A,IU 1350 1350 1360 1350 1360 1340 1350 Vitamin D,IU 300 300 290 300 300 300 300 Vitamin E,IU 6.3 6.3 6.3 6.3 6.3 6.3 6.3 Vitamin K, mcg 9 999999 Thiamin, B1, mcg 200 200 200 200 200 200 200 Riboﬂ avin, B2, mcg 300 300 290 300 300 300 300 Vitamin B6, mcg 150 150 151 150 151 150 150 Vitamin B12, mcg 0.25 0.25 0.26 0.25 0.25 0.24 0.25 Niacin, mcg 4000 4000 4100 4000 4000 4000 4000 Folic acid, mcg 40 40 41 40 40 40 40 Pantothenic acid, mcg 1200 1220 1220 1200 1200 1200 1200 Biotin, mcg 4 4 4.1 4 4 4 4 Vitamin C,mg 20 20 20 20 20 20 20 Choline,mg 24 24 24 24 24 24 24 Inositol,mg 44 43 45 44 44 43 44 Total nucleotides,mg 4.2 4.2 4.2 4.2 4.2 4.1 4.2 Minerals Calcium,mg 165 165 165 165 165 164 165 Phosphorus,mg 90 90 90 90 90 90 90 Magnesium,mg 9 999999 Iron,mg 1.8 1.8 1.81 1.8 1.81 1.8 1.8 Zinc,mg 1.5 1.5 1.51 1.5 1.51 1.5 1.5 Manganese, mcg 6.3 6.3 6.3 6.3 6.3 6.3 6.3 Copper, mcg 120 122 122 120 120 120 120 Iodine, mcg 25 25 26 25 25 25 25 Selenium, mcg 5 555555 Sodium,mg 70 72 71 70 70 70 70 Potassium,mg 98 98 99 98 99 99 98 Chloride,mg 106 107 106 106 107 106 106 Additional Nutrients Chromium, mcg NA NA NA NA NA NA NA Molybdenum, mcg NA NA NA NA NA NA NA ARA,mg 34 33 35 33 33 33 34 DHA,mg 17 17.2 17.2 17 17 17 17 PRSL, mOsm 30 NS NS NS NS NS 30

The nutritional profi les of the formula prepared in accordance with the calorie modifi cations provided here may not Due to rounding, percentages and volume added may not be exactly the same. 130 meet the nutritional requirements of every premature or low birth weight infant. It is up to the individual. ® Enfamil Enfamil Enfamil® Premature Enfamil® Prematuree Nutrients per 100 Cal Prematureure 24 Cal HPHP 30 Cal + 24 Cal HP Approximate Ratio n/a/ 1:5 1:2 1:1 2:151 5:1 Cal/fl oz 24 25 26 27 28 29 ® Calories 100 100 100 100 100 100 Premature Caloric Recipes Volume, mL/100 Cal 123 118 114 109 106 101 Protein, g whey:casein ratio=80:20 3.6 3.5 3.5 3.4 3.5 3.3 Fat,g 5 55555 Carbohydrate,g 10.5 10.5 10.6 10.6 10.8 10.7 Vitamins Vitamin A,IU 1350 1350 1360 1350 1360 1340 Vitamin D,IU 300 300 290 300 300 300 Vitamin E,IU 6.3 6.3 6.3 6.3 6.3 6.3 Vitamin K, mcg 9 99999 Thiamin, B1, mcg 200 200 200 200 200 200 Ribofl avin, B2, mcg 300 300 290 300 300 300 Vitamin B6, mcg 150 150 151 150 151 150 Vitamin B12, mcg 0.25 0.25 0.26 0.25 0.25 0.24 Niacin, mcg 4000 4000 4100 4000 4000 4000 Folic acid, mcg 40 40 41 40 40 40 Pantothenic acid, mcg 1200 1220 1220 1200 1200 1200 Biotin, mcg 4 4 4.1 4 4 4 Vitamin C,mg 20 20 20 20 20 20 Choline,mg 24 24 24 24 24 24 Inositol,mg 44 43 45 44 44 43 Total nucleotides,mg 4.2 4.2 4.2 4.2 4.2 4.1 Minerals Calcium,mg 165 165 165 165 165 164 Phosphorus,mg 90 90 90 90 90 90 Magnesium,mg 9 99999 Iron,mg 1.8 1.8 1.81 1.8 1.81 1.8 Zinc,mg 1.5 1.5 1.51 1.5 1.51 1.5 Manganese, mcg 6.3 6.3 6.3 6.3 6.3 6.3 Copper, mcg 120 122 122 120 120 120 Iodine, mcg 25 25 26 25 25 25 Selenium, mcg 5 55555 Sodium,mg 70 72 71 70 70 70 Potassium,mg 98 98 99 98 99 99 Chloride,mg 106 107 106 106 107 106 Additional Nutrients Chromium, mcg NA NA NA NA NA NA Molybdenum, mcg NA NA NA NA NA NA ARA,mg 34 33 35 33 33 33 DHA,mg 17 17.2 17.2 17 17 17 PRSL, mOsm 32 NS NS NS NS NS

IU = International Units mcg = Micrograms NS = Non Specifi ed mg = Milligrams NA = None Added PRSL = Potential Renal Solute Load 131 ® ® Enfamil Enfamil® Premature Enfamil® Prematuree Enfamil Nutrients per 100 mL Prematureure Prematureure 24 Cal 30 Cal + 24 Cal 30 Cal Approximate Ratio n/a/ 1:5 1:2 1:1 2:151 5:1 n/a/ Cal/fl oz 24 25 26 27 28 29 30 Calories 81 85 88 92 94 99 101 Volume, mL/100 Cal 100 100 100 100 100 100 100 Protein, g whey:casein ratio=80:20 2.7 2.8 2.9 3.1 3.1 3.2 3.3 Fat,g 4.1 4.2 4.4 4.6 4.7 4.9 5.1 Carbohydrate,g 8.8 9.2 9.6 9.9 10.2 10.7 10.9 Vitamins Vitamin A,IU 1100 1140 1190 1240 1280 1320 1370 Vitamin D,IU 240 250 260 270 280 300 300 Vitamin E,IU 5.1 5.4 5.5 5.8 6 6.2 6.4 Vitamin K, mcg 7.3 7.6 7.9 8.2 8.5 8.9 9.1 Thiamin, B1, mcg 162 169 175 186 190 200 200 Ribofl avin, B2, mcg 240 250 260 270 280 300 300 Vitamin B6, mcg 122 127 133 137 143 148 152 Vitamin B12, mcg 0.2 0.21 0.22 0.23 0.24 0.24 0.25 Niacin, mcg 3200 3400 3600 3600 3800 3900 4100 Folic acid, mcg 32 34 36 36 38 39 41 Pantothenic acid, mcg 970 1030 1070 1100 1130 1180 1220 Biotin, mcg 3.2 3.4 3.6 3.6 3.8 3.9 4.1 Vitamin C,mg 16.2 16.9 17.5 18.6 19 20 20 Choline,mg 19.5 20 21 22 22 24 24 Inositol,mg 36 37 39 40 42 42 45 Total nucleotides,mg 3.4 3.5 3.7 3.8 3.9 4.1 4.3 Minerals Calcium,mg 134 139 145 151 156 162 167 Phosphorus,mg 73 76 79 82 85 89 91 Magnesium,mg 7.3 7.6 7.9 8.2 8.5 8.9 9.1 Iron,mg 1.46 1.52 1.58 1.64 1.71 1.77 1.83 Zinc,mg 1.22 1.27 1.33 1.37 1.43 1.48 1.52 Manganese, mcg 5.1 5.4 5.5 5.8 6 6.2 6.4 Copper, mcg 97 103 107 110 113 118 122 Iodine, mcg 20 21 22 23 24 25 25 Selenium, mcg 4.1 4.2 4.4 4.6 4.7 4.9 5.1 Sodium,mg 57 61 62 64 66 69 71 Potassium,mg 80 83 87 90 93 97 99 Chloride,mg 86 90 93 97 101 104 107 Additional Nutrients Chromium, mcg NA NA NA NA NA NA NA Molybdenum, mcg NA NA NA NA NA NA NA ARA,mg 28 28 30 31 31 32 34 DHA,mg 13.8 14.5 15.1 15.6 16.1 16.8 17.2 PRSL, mOsm 25 NS NS NS NS NS 30

The nutritional profi les of the formula prepared in accordance with the calorie modifi cations provided here may not Due to rounding, percentages and volume added may not be exactly the same. 132 meet the nutritional requirements of every premature or low birth weight infant. It is up to the individual. ® Enfamil Enfamil Enfamil® Premature Enfamil® Prematuree Nutrients per 100 mL Prematureure 24 Cal HPHP 30 Cal + 24 Cal HP Approximate Ratio n/a/ 1:5 1:2 1:1 2:151 5:1 Cal/fl oz 24 25 26 27 28 29 ® Calories 81 85 88 92 94 99 Premature Caloric Recipes Volume, mL/100 Cal 100 100 100 100 100 100 Protein, g whey:casein ratio=80:20 2.9 3 3 3.1 3.2 3.2 Fat,g 4.1 4.2 4.4 4.6 4.7 4.9 Carbohydrate,g 8.5 8.9 9.3 9.7 10.2 10.6 Vitamins Vitamin A,IU 1100 1140 1190 1240 1280 1320 Vitamin D,IU 240 250 260 270 280 300 Vitamin E,IU 5.1 5.4 5.5 5.8 6 6.2 Vitamin K, mcg 7.3 7.6 7.9 8.2 8.5 8.9 Thiamin, B1, mcg 162 169 175 186 190 200 Ribofl avin, B2, mcg 240 250 260 270 280 300 Vitamin B6, mcg 122 127 133 137 143 148 Vitamin B12, mcg 0.2 0.21 0.22 0.23 0.24 0.24 Niacin, mcg 3200 3400 3600 3600 3800 3900 Folic acid, mcg 32 34 36 36 38 39 Pantothenic acid, mcg 970 1030 1070 1100 1130 1180 Biotin, mcg 3.2 3.4 3.6 3.6 3.8 3.9 Vitamin C,mg 16.2 16.9 17.5 18.6 19 20 Choline,mg 19.5 20 21 22 22 24 Inositol,mg 36 37 39 40 42 42 Total nucleotides,mg 3.4 3.5 3.7 3.8 3.9 4.1 Minerals Calcium,mg 134 139 145 151 156 162 Phosphorus,mg 73 76 79 82 85 89 Magnesium,mg 7.3 7.6 7.9 8.2 8.5 8.9 Iron,mg 1.46 1.52 1.58 1.64 1.71 1.77 Zinc,mg 1.22 1.27 1.33 1.37 1.43 1.48 Manganese, mcg 5.1 5.4 5.5 5.8 6 6.2 Copper, mcg 97 103 107 110 113 118 Iodine, mcg 20 21 22 23 24 25 Selenium, mcg 4.1 4.2 4.4 4.6 4.7 4.9 Sodium,mg 57 61 62 64 66 69 Potassium,mg 80 83 87 90 93 97 Chloride,mg 86 90 93 97 101 104 Additional Nutrients Chromium, mcg NA NA NA NA NA NA Molybdenum, mcg NA NA NA NA NA NA ARA,mg 28 28 30 31 31 32 DHA,mg 13.8 14.5 15.1 15.6 16.1 16.8 PRSL, mOsm 26 NS NS NS NS NS

IU = International Units mcg = Micrograms NS = Non Speciﬁ ed mg = Milligrams NA = None Added PRSL = Potential Renal Solute Load 133 ® ® • NeoMed accessories available: EnfamilE ° Transfer lids to help ensure aseptic preparation DHAD & ARA ° ENFit ® syringes provide accurate and safe administration, and can help reduce lipid loss SSupplement NeoMed is a registered trademark of NeoMed, Inc. ENFit is a registered trademark of GEDSA.

Description/Indication Product Forms Enfamil DHA & ARA Supplement is a DHA and ARA supplement designed to Enfamil DHA & ARA Supplement is available in ready-to-use Nursette® help infants receive supplemental amounts of DHA and ARA. Enfamil DHA bottles. For ordering information, please refer to page 297. & ARA Supplement is a commercially sterile, emulsiﬁ ed liquid that provides 20 mg DHA and 40 mg ARA per 0.5 mL. Contribution of DHA and ARA from other dietary sources should be accounted for in the infant’s diet. Composition Ingredients: Water, Mortierella alpina oil, Schizochytrium sp. oil, and less than 2%: modiﬁ ed corn starch and ascorbyl palmitate.

Product Features WARNING: Not for parenteral (I.V.) use. • Commercially sterile, emulsiﬁ ed liquid Note: CONTRIBUTION OF DHA AND ARA FROM OTHER DIETARY • 2 Calories per 0.5 mL SOURCES SHOULD BE ACCOUNTED FOR IN THE BABY’S DIET. • No measurable impact on osmolality THIS PRODUCT SHOULD BE USED ONLY AS DIRECTED BY THE BABY’S • Flexible application provides 20 mg DHA and 40 mg ARA per 0.5 mL DOCTOR. REFER TO HOSPITAL PROTOCOLS FOR TUBE FEEDING. • For enteral or oral feeding

134 BCADEnfamil 1 ® DHA & ARA Supplement 135 2 40 mg* 20 mg* Per 0.5 mL Product nutrient values and ingredients are subject to change. Please see product label for current information. current label for product Please see to change. are subject values and ingredients Product nutrient oil) oil) Schizochytrium sp. Schizochytrium sp. Mortierella alpina Mortierella alpina (docosahexaenoic acid from (docosahexaenoic (arachidonic acid from (arachidonic acid Calories ARA DHA SUPPLEMENT FACTS SUPPLEMENT NUTRIENTS * Daily value not established. • MFGM and DHA—brain-building nutrition inspired by breast milk Enfamil • DHA to promote brain and eye development2-9: ™ ° DHA at the clinically proven amount of 0.32% of total fatty acids, NeuroPro the same amount as the worldwide breast milk average10,|| ® EnfaCare • 20% of the fat blend from medium-chain triglycerides (MCT) oil • 80:20 whey-to-casein ratio patterned after early breast milk11,¶ • Has choline to help support brain development • Kosher, Halal Description/IndicationDesscription/In Enfamil NeuroPro EnfaCare is a milk-based, 22 Cal/fl oz, iron-fortifi ed, * Increased caloric density, protein, and some vitamins and minerals compared to standard term formula to help support weight and growth in babies born prematurely. post-discharge formula that has enriched nutrition for infants who were † In amounts supported by clinical research. born prematurely or with low birth weight*. Enfamil NeuroPro EnfaCare is ‡ When used in a program of Enfamil® formulas: Enfamil® Premature, Enfamil® EnfaCare® and the only post-discharge formula that has a fat-protein blend of MFGM and Enfamil® Infant. Studied before the reformulation of EnfaCare. † § Enfamil NeuroPro Infant formula has 78 mg calcium, 43 mg phosphorous, and DHA, previously only found in breast milk . Enfamil NeuroPro EnfaCare has 75 IU (powder)/70 IU (ready-to-use) vitamin D per 100 Calories. vitamin and mineral amounts specially tailored for premature babies’ fi rst || Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard year of life after discharge from the hospital. deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women10. ¶ Based on whey-to-casein ratio 3-5 days after lactation begins.

Product Forms Product Features Enfamil NeuroPro EnfaCare is available in powder and ready-to-use liquid. • Clinically proven to promote catch-up growth to help support For ordering information, please refer to page 297. developmental outcomes during the ﬁ rst year1,‡: ° 2.8 g protein/100 Calories, which is a higher protein level thanEnfamil NeuroPro™ Infant formula ° 54% more calcium than Enfamil NeuroPro Infant formula§ ° 53% more phosphorus than Enfamil NeuroPro Infant formula§ ° 25% more vitamin D than Enfamil NeuroPro Infant formula§

136 Enfamil NeuroPro™ EnfaCare® 137 Per 100 mLPer 100 Per 100 grams 11.9 11.9 80 (4.5 ﬂ oz) (4.5 ﬂ 2.8 2.8 2.1 2.1 14 1.81 1.8 1 1.34 0.74 1.34 0.74 9 5 443320 9 9 6.7 6.7 45 886640 6 6 4.5 4.5 30 5.3 5.3 3.9 3.9 27 0.3 0.3 0.22 0.22 1.5 2.8 2.8 2.1 2.1 14 21 21 15.6 15.6 105 90 90 67 67 450 15 15 11.2 11.2 75 7575 56 56 380 3778 37 78 28 58 28 58 185 390 242466 24 24 66 17.9 17.9 49 17.9 17.9 49 120 120 330 10.4 10.4 7.7 7.7 52 26 26 19.3 19.3 130 67 67 50 50 340 Powder Liquid Powder Liquid(500 Cal) Powder 119120 89450 89 450 2.4 330 330 2300 105 105 78 78 530 120 120 89 89 600 780 780 580 580 3900 850 850 630 630 4300 180200 180 200 134 149 134 149 900 1000 1000 1000 740 740 5000 for current information. Please see product label and ingredients are subject to change. Product nutrient values 16 16 mg

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, Vitamins/Other Nutrients Vitamin A Vitamin D Vitamin E Vitamin K Thiamin Selenium Sodium Iodine Copper Zinc Manganese Water Carbohydrate Potassium Chloride Biotin Vitamin C Inositol Minerals Calcium Phosphorus Magnesium Choline Iron Linoleic acid Ribofl Vitamin B Niacin Folic acid Pantothenic acid Vitamin B Protein Fat (Normal Dilution) Per 100 Calories NUTRIENTS NUTRIENT FACTS Nutrient Density 22 Calories/fl oz 22 Calories/fl oz Powder Liquid Protein (% Calories) 11 Osmolality (mOsm/kg water) 310 230 Fat (% Calories) 47 Osmolarity (mOsm/L) 280 200 Carbohydrate (% Calories) 42 Lactose-free No No Potential Renal Solute Load (mOsm/100 Calories)12 25 Potential Renal Solute Load (mOsm/100 mL)12 18.4

Schizochytrium sp. oil††, mono- and diglycerides, soy lecithin, Composition calcium phosphate, potassium citrate, calcium citrate, magnesium Ingredients: Powder: Nonfat milk, whey protein concentrate, corn syrup phosphate, sodium chloride, potassium chloride, sodium citrate, ferrous solids, lactose, high oleic sunfl ower oil, soy oil, medium chain triglycerides sulfate, zinc sulfate, cupric sulfate, potassium iodide, manganese sulfate, (MCT oil), whey-protein lipid concentrate#, coconut oil and less than sodium selenite, carrageenan, ascorbic acid, vitamin E acetate, niacinamide, 2%: Mortierella alpina oil**, Schizochytrium sp. oil††, calcium phosphate, calcium pantothenate, thiamin hydrochloride, vitamin A palmitate, ribofl avin, calcium carbonate, ferrous sulfate, magnesium phosphate, zinc sulfate, vitamin B6 hydrochloride, folic acid, vitamin D3, vitamin K1, biotin, vitamin potassium citrate, sodium chloride, cupric sulfate, manganese sulfate, B12, choline chloride, inositol, nucleotides (cytidine 5’-monophosphate, sodium selenite, potassium iodide, soy lecithin, inositol, vitamin A palmitate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, ascorbic acid, niacinamide, calcium pantothenate, thiamin hydrochloride, disodium guanosine 5’-monophosphate), taurine, L-carnitine. ribofl avin, vitamin B6 hydrochloride, vitamin D3, folic acid, vitamin K1, biotin, vitamin B12, choline chloride, vitamin E acetate, nucleotides # A source of MFGM (milk fat globule membrane). (cytidine 5’-monophosphate, adenosine 5’-monophosphate, disodium ** A source of arachidonic acid (ARA). †† A source of docosahexaenoic acid (DHA). uridine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine. Ingredients: Ready To Use (2 fl oz Nursette®): Water, nonfat milk, maltodextrin, lactose, whey protein concentrate, high oleic sunfl ower Potential Allergens oil, soy oil, medium chain triglycerides (MCT oil), whey protein-lipid Enfamil NeuroPro™ EnfaCare® contains milk and soy. concentrate#, coconut oil and less than 0.5%: Mortierella alpina oil**,

138 Enfamil NeuroPro

References 1. Clandinin MT, Van Aerde JE, Merkel KL, et al. Growth and development of preterm infants 7. Hoffman DR, Birch EE, Birch DG, et al. Impact of early dietary intake and blood lipid fed infant formulas containing docosahexaenoic acid and arachidonic acid. J Pediatr. composition of long-chain polyunsaturated fatty acids on later visual development. J Pediatr 2005;146:461–468. Gastroenterol Nutr. 2000;31:540-553. 2. Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic 8. Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturation of term infants fed long-chain acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201–209. polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am J Clin Nutr. 3. Birch EE, Garﬁ eld S, Hoffman DR, at al. A randomized controlled trial of early dietary supply 2005;81:871-879. of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med 9. Morale SE, Hoffman DR, Castañeda YS, et al. Duration of long-chain polyunsaturated fatty Child Neurol. 2000;42:174–181. acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203. 4. Birch EE, Hoffman DR, Castañeda YS, et al. A randomized controlled trial of long-chain 10. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid

polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. ™ EnfaCare of age. Am J Clin Nutr. 2002;75:570–580. 11. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta 5. Hoffman DR, Birch EE, Castañeda YS, et al. Visual function in breast-fed term infants weaned Paediatr. 1992;81:107-112. to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized 12. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute in infancy. J Pediatr. clinical trial. J Pediatr. 2003;142(6):669–677. 1999;134:11-14. 6. Hoffman DR, Birch EE, Castaneda YS, et al. Maturation of visual and mental function in 18-month-old infants receiving dietary long-chain polyunsaturated fatty acids [abstract].

FASEB J. 2003;17:A727–A728. Abstract 445.1. ®

139 • DHA to promote brain and eye development2-9: ® ° DHA at the clinically proven amount of 0.32% of total fatty acids, Enfamil the same amount as the worldwide breast milk average10,‡ EnfaCare® • 20% of the fat blend from medium-chain triglycerides (MCT) oil • 80:20 whey-to-casein ratio patterned after early breast milk11,§ • Has choline to help support brain development • Kosher, Halal

Description/IndicationDescript * Increased caloric density, protein, and some vitamins and minerals compared to standard term formula to help support weight and growth in babies born prematurely. Enfamil EnfaCare is a milk-based, 22 Cal/fl oz, iron-fortifi ed, post-discharge † When used in a program of Enfamil® formulas: Enfamil® Premature, Enfamil EnfaCare and formula with enriched nutrition for infants who were born prematurely or Enfamil® Infant. * ‡ Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation with low birth weight . Enfamil EnfaCare contains vitamin and mineral levels of total fatty acids) based on an analysis of 65 studies of 2,474 women10. specially tailored for premature babies’ fi rst year of life after discharge from § Based on whey-to-casein ratio 3-5 days after lactation begins. the hospital. Enfamil EnfaCare is typically used during the fi rst year of life for infants from approximately 1800 g in weight.

Product Forms Enfamil EnfaCare is available in ready-to-use liquid. For ordering Product Features information, please refer to page 297. • Clinically proven to promote catch-up growth to help support developmental outcomes during the ﬁ rst year1,†: ° 2.8 g protein/100 Calories, which is a higher protein level than Enfamil PREMIUM® Infant formula ° 54% more calcium than Enfamil PREMIUM Infant formula ° 53% more phosphorus than Enfamil PREMIUM Infant formula ° 25% more vitamin D than Enfamil PREMIUM Infant formula

140 Enfamil® EnfaCare® 141 oz 17.8 11.9 No 18.4 230 200 8 5.9 6 4.4 2.8 2.1 1.8 1.33 1 0.74 16 24 78 58 24 17.8 66 49 15 11.1 90 67 2137 15.6 27 120 89 105 78 12 (mOsm/100 mL) mg

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(% Calories) , Carbohydrate Vitamin E Fat Vitamin D Vitamins/Other Nutrients Vitamins/Other Vitamin A Ribofl Vitamin B Vitamin B Folic acid Niacin Pantothenic acid Linoleic acid Vitamin K Water Protein (Normal Dilution) Per 100 Calories Per 100 mL Per 100 Calories Per 100 mL NUTRIENTS Thiamin Carbohydrate Carbohydrate Potential Renal Solute Load Fat Protein Nutrient Density 22 Calories/fl NUTRIENT FACTS References Composition 1. Clandinin MT, Van Aerde JE, Merkel KL, et al. Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. J Pediatr. 2005;146:461– Ingredients: Ready To Use (8 fl oz bottle): Water, nonfat milk, maltodextrin, 468. lactose, whey protein concentrate, high oleic sunfl ower oil, soy oil, medium 2. Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic acid chain triglycerides (MCT oil), coconut oil and less than 0.5%: Mortierella and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201–209. alpina oil||, Crypthecodinium cohnii oil¶, mono- and diglycerides, soy lecithin, 3. Birch EE, Garfi eld S, Hoffman DR, at al. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child calcium phosphate, calcium hydroxide, potassium citrate, calcium citrate, Neurol. 2000;42:174–181. magnesium chloride, sodium chloride, potassium chloride, sodium citrate, 4. Birch EE, Hoffman DR, Castañeda YS, et al. A randomized controlled trial of long-chain ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, manganese polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. Am J Clin Nutr. 2002;75:570–580. sulfate, sodium selenite, rice starch, sodium ascorbate, ascorbic 5. Hoffman DR, Birch EE, Castañeda YS, et al. Visual function in breast-fed term infants weaned to acid, vitamin E acetate, niacinamide, calcium pantothenate, thiamin formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. J hydrochloride, vitamin A palmitate, ribofl avin, vitamin B6 hydrochloride, Pediatr. 2003;142(6):669–677. 6. Hoffman DR, Birch EE, Castaneda YS, et al. Maturation of visual and mental function in folic acid, vitamin D3, vitamin K1, biotin, vitamin B12, choline chloride, 18-month-old infants receiving dietary long-chain polyunsaturated fatty acids [abstract]. FASEB J. inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine 2003;17:A727–A728. Abstract 445.1. 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 7. Hoffman DR, Birch EE, Birch DG, et al. Impact of early dietary intake and blood lipid composition 5’-monophosphate), taurine, L-carnitine. of long-chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol Nutr. 2000;31:540-553. 8. Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturation of term infants fed long-chain || A source of arachidonic acid (ARA). polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am J Clin Nutr. ¶ A source of docosahexaenoic acid (DHA). 2005;81:871-879. 9. Morale SE, Hoffman DR, Castañeda YS, et al. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203. 10. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. Potential Allergens 11. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 1992;81:107-112. Enfamil® EnfaCare® contains milk and soy. 12. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute in infancy. J Pediatr. 1999;134:11-14.

142 Enfamil

Notes

® EnfaCare

143 ® Enfamil Product Form Human Milk Enfamil Human Milk Fortifi er Powder is available in powder. For ordering information, please refer to page 298. Fortifier Powder Composition Ingredients: Powder: Medium-chain triglycerides (MCT) oil, milk protein Description/Indication isolate, whey protein isolate hydrolysate, soybean oil, calcium phosphate, Enfamil Human Milk Fortifi er Powder is to be added to expressed breast milk calcium glycerophosphate, calcium gluconate and less than 2%: corn syrup for feeding premature or low-birth-weight infants. It provides enriched nutrition solids, soy lecithin, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin needed by these special babies while still allowing them to receive their K1, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin mother’s milk. Enfamil Human Milk Fortifi er Powder is milk-based and, when B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, mixed with mother’s milk, increases the levels of protein, energy, calcium, magnesium phosphate, potassium phosphate, ferrous sulfate, zinc sulfate, phosphorus and other nutrients, producing a diet more suited to the nutritional cupric sulfate, sodium citrate, potassium chloride, potassium citrate. needs of the rapidly growing premature infant. Enfamil Human Milk Fortifi er Powder was specifi cally designed to be used as a supplement to be added to mother’s milk collected after 2 weeks postpartum. Potential Allergens Enfamil Human Milk Fortifi er Powder contains milk and soy.

Product Features CAUTION: Nutritionally incomplete. To be used only under the supervision of • Well tolerated a physician. • 1.1 g protein/4 packets Regarding use in extremely low-birth-weight infants (ELBW–1 kg or less): • Added iron to reduce the need for additional iron supplementation Hypercalcemia has been reported in some of these infants on full enteral feeds of mothers’ milk supplemented with human milk fortiﬁ ers. • Includes fat and essential fatty acids • Low osmolality Reference • Kosher, Halal 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute in infancy. J Pediatr. 1999;134:11-14. 144 Enfamil® Human Milk Fortifier Powder 145 * No +35 1.44 1 2.7 0.72 50 90 12 10 25 44 16 13 29 730 Not available 9.8 per 4 packets Packets (14 Cal) Packets (14 Per 4–0.025 oz (0.71 g)Per 4–0.025 1 (mOsm)

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, , Iron Magnesium Phosphorus Calcium Minerals Vitamin Biotin Pantothenic acid Manganese Folic acid Copper Sodium Chloride Lactose-free Osmolality Potassium Osmolarity Zinc Potential Renal Solute Load 6 62 32 0.08 1 4.4 1.1 0.18 4.6 17 < 0.4 150 950 140 150 220 115 3000 Packets (14 Cal) Packets (14 29 per 100 Calories Please see product label for current information. subject to change. ingredients are Product nutrient values and 1 (mOsm) mcg

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Description/Indication Product Form Enfamil Liquid Human Milk Fortifi er High Protein is added to expressed Enfamil Liquid Human Milk Fortifi er High Protein is available in an ultra- breast milk for feeding premature and low-birth-weight infants. It provides concentrated liquid. For ordering information, please refer to page 298. enriched nutrition needed by these special babies while still allowing them to receive their mother’s milk. Enfamil Liquid Human Milk Fortifi er High Protein increases the levels of protein, energy, calcium, phosphorus, iron, vitamin D and other nutrients, producing a diet more suited to the nutritional needs of the rapidly growing premature infant. It has 4 g of protein per 100 Cal when mixed with preterm human milk at the 24 Calorie per fl uid ounce dilution*.

Product Features • Helps to promote growth ° 4 g protein/100 Cal of fortifi ed preterm human milk* to help promote growth • Commercially sterile, convenient 5.5 fl oz bottle designed for easy batch fortifi cation mixing

146 Enfamil® Liquid Human Milk Fortifier High Protein 147 † ‡,|| ‡,§ No 18.3 33 ed Preterm ed Per 100 Cal Per 100 Breast Milk Breast Fortiﬁ

† . 1 78 80 2 (120 mL) 2 20 mL Plus 100 mL 20 mL Plus Preterm Breast Milk Preterm Breast 0.84 3.9 4.1 0.24 1.33 1.37 2.5 10.4 10.7 0.44 1.85 1.9 6.8 55 57 3.8 20 20 6.9 86 88 7.7 340.46 35 5.1 5.3 er Only er 15 98 101 29 141 145 15.8 11.3 95 98 230 1150 1190 Per 5 mL (mOsm/100 Calories) (mOsm/20 mL) Fortiﬁ

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† (120 mL) 20 mL Plus 100 mL 20 mL Plus Preterm Breast Milk Preterm Breast 0.11 7.7 7.9 1.42 7.7 7.9 3.8 104 107 0.16 0.66 0.68 1.4 6 6.2 0.58 5.8 6 0.56 3.9 4 er Only er 58 710 730 66 290 300 35 146 150 46 193 200 47 200 200 290 1210 1240 920 3900 4000 Fortiﬁ mcg

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, (% Calories) Carbohydrate Linoleic acid Thiamin Vitamins/Other Nutrients Vitamins/Other Ribofl Vitamin B Vitamin K Vitamin B Water Vitamin A Niacin Vitamin D Protein (Normal Dilution)Fat Per 5 mL Vitamin E NUTRIENTS Carbohydrate Carbohydrate Protein Fat NUTRIENT FACTS Nutrient Density Per 20 mL (30 Cal) † Calculated human breast milk compiled from multiple published studies; protein value used for preter using values for preterm † ‡ Fortifi er only. ‡ Fortifi 5 mL to 25 mL preterm human milk. When mixed at normal dilution, § human milk. 32 mOsm/120 mL when 20 mL added to 100 mL preterm || PRETERM HUMAN MILK CALORIC RECIPES PRETERM HUMAN MILK CALORIC RECIPES Nutrients per 100 Cal Nutrients per 100 mL ~Cal/fl oz 22 24 ~Cal/mL 0.74 0.81 Preterm breast milk 50 mL 25 mL Preterm human milk 50 mL 25 mL ++++++ ELHMF High Protein 5 mL 5 mL ELHMF High Protein 5 mL 5 mL Final volume, mL 55 30 Final volume, mL 55 30 Energy, Cal 100 100 Energy, Cal 75 81 Protein, g 3.3 4 Protein, g 2.5 3.3 Fat, g 5.7 6 Fat, g 4.2 4.8 Carbohydrate, g 9.2 7.9 Carbohydrate, g 6.8 6.4 Water, g 118 107 Water, g 88 87 Vitamins Vitamins/Other Nutrients Vitamin A activity, IU 770 1240 Vitamin A activity, IU 570 1010 Vitamin D, IU 124 200 Vitamin D, IU 93 167 Vitamin E, IU 3.9 6.2 Vitamin E, IU 2.9 5 Vitamin K, mcg 5.9 7.9 Vitamin K, mcg 4.4 6.4 Thiamin (Vitamin B1), mcg 123 200 Thiamin (Vitamin B1), mcg 92 161 Ribofl avin (Vitamin B2), mcg 194 300 Ribofl avin (Vitamin B2), mcg 145 240 Vitamin B6, mcg 93 150 Vitamin B6, mcg 69 122 Vitamin B12, mcg 0.41 0.68 Vitamin B12, mcg 0.31 0.55 Niacin, mcg 2500 4000 Niacin, mcg 1860 3300 Folic acid (Folacin), mcg 23 35 Folic acid (Folacin), mcg 16.8 28 Pantothenic acid, mcg 840 1190 Pantothenic acid, mcg 630 960 Biotin, mcg 2.7 4.1 Biotin, mcg 2 3.3 Vitamin C (Ascorbic acid), mg 14.6 20 Vitamin C (Ascorbic acid), mg 10.9 16.7 Minerals Minerals Calcium, mg 75 118 Calcium, mg 101 145 Phosphorus, mg 42 65 Phosphorus, mg 56 80 Magnesium, mg 3.8 4.3 Magnesium, mg 5.1 5.3 Iron, mg 0.88 1.54 Iron, mg 1.18 1.9 Zinc, mg 0.77 1.11 Zinc, mg 1.04 1.37 Manganese, mcg 4.9 8.7 Manganese, mcg 6.5 10.7 Copper, mcg 62 82 Copper, mcg 83 101 Iodine, mcg 16.2 14.8 Iodine, mcg 22 18.4 Selenium, mcg 2.2 2 Selenium, mcg 2.9 2.5 Sodium, mg 38 46 Sodium, mg 51 57 Potassium, mg 66 79 Potassium, mg 89 98 Chloride, mg 65 72 Chloride, mg 88 88 Additional Nutrients Linoleic acid, mg 730 730 Linoleic acid, mg 540 590 Linolenic acid, mg 54 60 Linolenic acid, mg 40 48 ARA, mg 32 38 ARA, mg 24 31 DHA, mg 21 24 DHA, mg 15.6 19.2

148 Enfamil® Liquid Human Milk Fortifier High Protein 149 0.36 0.6 1.84 2.7 4.27.5 4.8 7.1 3.8 4.3 3.3 5.3 2.8 5 2.20.85 3.4 1.52 0.62 0.97 4.8 8.6 1.82 1.67 15.6 19.2 46 54 24 31 92 161 55 30 73 116 82 133 75 81 41 63 8987 88 24 158 35 55 75 13.629 12.5 38 64 78 51 59 16 21 14.5 13.3 24 22 5 mL 5 mL 620 670 165 260 660 1090 620 960 0.74 0.81 50 mLmL 25 2000 3400 mg

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, Linoleic acid Minerals Calcium Additional Nutrients Linolenic acid TERM TERM mL per 100 Nutrients ~Cal/mL human milk Term ELHMF High Protein Final volume Vitamins/Other Nutrients Vitamin A activity ARA DHA Vitamin B Riboﬂ Energy Phosphorus Vitamin D Vitamin B Niacin Folic acid Protein Fat Magnesium Carbohydrate Water Vitamin E Pantothenic acid Iron Biotin Vitamin K Thiamin Vitamin C Zinc Manganese Copper Iodine Selenium Choline Sodium Potassium Chloride Inositol 0.48 0.74 5.11.14 5.2 1.87 4.43.7 6.6 6.2 2.9 4.2 0.826.4 1.19 10.6 2.4 2.1 2.45.6 3.3 6 32 43 3221 38 24 62 67 9854 143 78 55 30 32 27 2119.4 26 16.4 7318.2 92 15.4 10 8.7 39 47 8568 95 73 22 24 220 320 122 200 830 1180 109 164 830 820 880116 1340 194 100 100 118 108 5 mL 5 mL 50 mL 25 mL 2700 4200 mg

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, Vitamin B Ribofl Biotin Pantothenic acid Vitamin B Niacin Folic acid DHA ARA Linolenic acid Additional Nutrients Linoleic acid Phosphorus Magnesium Minerals Calcium Vitamin D Vitamin E Iron Zinc Vitamins/Other Nutrients Vitamin A activity Term human milk Term ELHMF High Protein Nutrients per 100 Cal per 100 Nutrients ~Cal/fl TERM TERM Final volume Vitamin K Thiamin Energy Choline Inositol Vitamin C Manganese Copper Protein Iodine Selenium Sodium Water Fat Carbohydrate Potassium Chloride References Composition 1. Data on fi le, Mead Johnson Nutrition, September 7, 2010. Ingredients: Water, whey protein isolate hydrolysate (milk), medium chain 2. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute in infancy. J Pediatr. 1999; triglycerides (MCT oil), soy oil and less than 2%: Mortierella alpina oil||, 134:11-14. Schizochytrium Sp. oil¶, pectin, vitamin A palmitate, vitamin E acetate, vitamin D3, vitamin K1, thiamin hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, calcium citrate, calcium phosphate, cupric sulfate, sodium citrate, potassium citrate, calcium chloride, ferrous sulfate, magnesium phosphate, zinc sulfate.

|| A source of arachidonic acid (ARA). ¶ A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil® Liquid Human Milk Fortiﬁ er High Protein contains milk and soy.

CAUTION: Nutritionally incomplete. To be used only under the supervision of a physician.

150 Enfamil

Notes

® Liquid Human Milk Fortifier High Protein

151 • 3.4 g of protein per 100 Cal when mixed with preterm human milk Enfamil® Liquid at the 24 Calorie per ﬂ uid ounce dilution* • Protein source is partially hydrolyzed whey protein Human Milk • DHA and ARA to help support brain and eye development

Fortifier Standard * When mixed as directed: 5 mL HMF + 25 mL preterm human milk. Protein

Product Form Description/Indication Enfamil Liquid Human Milk Fortifi er Standard Protein is available in an ultra- Enfamil Liquid Human Milk Fortifi er Standard Protein is added to expressed concentrated liquid. For ordering information, please refer to page 298. breast milk for feeding premature and late preterm infants. It increases protein, energy, calcium, phosphorus, iron, vitamin D and other nutrients to help promote growth in premature infants. It has 3.4 g of protein per 100 Cal when mixed with preterm human milk at the 24 Calorie per fl uid ounce dilution*.

Product Features • Enriched nutrition for premature and late preterm infants that allows them to still receive human milk • Increases protein, energy, calcium, phosphorus, iron, vitamin D and other nutrients of expressed breast milk • Commercially sterile, convenient 5.5 fl oz bottle designed for easy batch fortifi cation mixing • Concentrated fortifi er to increase nutrients and minimize need for other modular supplements

152 Enfamil® Liquid Human Milk Fortifier Standard Protein 153 † ‡,|| § No 30 14.7 ed Preterm ed Per 100 Cal Per 100 Breast Milk Breast Fortiﬁ

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, , Potential Renal Solute Load Potential Renal Solute Load Lactose-free Biotin Zinc Minerals Calcium Copper Potassium Iron Pantothenic acid Sodium Vitamin C Phosphorus Manganese Chloride Folic acid Magnesium † ‡ ‡ ‡ 66 12 22 ed Preterm ed Per 100 Cal Per 100 Breast Milk Breast Fortiﬁ information. product label for current see Please are subject to change. and ingredients Product nutrient values

† (120 mL) 20 mL Plus 100 mL 20 mL Plus Preterm Breast Milk Preterm Breast 0.28 8.4 8.7 1.42 7.7 7.9 3.8 104 107 0.16 0.66 0.68 1.4 6 6.2 0.58 5.8 6 0.42 3.3 3.4 er Only er 58 710 730 66 290 300 35 146 150 46 193 200 47 200 200 290 1210 1240 920 3900 4000 Fortiﬁ mcg

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, (% Calories) Carbohydrate Linoleic acid Thiamin Vitamins/Other Nutrients Vitamins/Other Ribofl Vitamin B Vitamin K Vitamin B Water Vitamin A Niacin Vitamin D Protein (Normal Dilution)Fat Per 5 mL Vitamin E NUTRIENTS Carbohydrate Carbohydrate Protein Fat NUTRIENT FACTS Nutrient Density Per 20 mL (30 Cal) † Calculated human breast milk compiled from multiple published studies; protein value used for preter using values for preterm † ‡ Fortifi er only. ‡ Fortifi 5 mL to 25 mL preterm human milk. When mixed at normal dilution, § human milk. 29 mOsm/120 mL when 20 mL added to 100 mL preterm || PRETERM HUMAN MILK CALORIC RECIPES PRETERM HUMAN MILK CALORIC RECIPES Nutrients per 100 Cal Nutrients per 100 mL ~Cal/fl oz 22 24 ~Cal/mL 0.74 0.81 Preterm breast milk 50 mL 25 mL Preterm human milk 50 mL 25 mL ++++++ ELHMF Standard Protein 5 mL 5 mL ELHMF Standard Protein 5 mL 5 mL Final volume, mL 55 30 Final volume, mL 55 30 Energy, Cal 100 100 Energy, Cal 75 81 Protein, g 3 3.4 Protein, g 2.2 2.8 Fat, g 5.7 6 Fat, g 4.2 4.8 Carbohydrate, g 9.6 8.7 Carbohydrate, g 7.1 7 Water, g 118 107 Water, g 88 87 Vitamins Vitamins/Other Nutrients Vitamin A activity, IU 770 1240 Vitamin A activity, IU 570 1010 Vitamin D, IU 124 200 Vitamin D, IU 93 167 Vitamin E, IU 3.9 6.2 Vitamin E, IU 2.9 5 Vitamin K, mcg 5.9 7.9 Vitamin K, mcg 4.4 6.4 Thiamin (Vitamin B1), mcg 123 200 Thiamin (Vitamin B1), mcg 92 161 Ribofl avin (Vitamin B2), mcg 194 300 Ribofl avin (Vitamin B2), mcg 145 240 Vitamin B6, mcg 93 150 Vitamin B6, mcg 69 122 Vitamin B12, mcg 0.41 0.68 Vitamin B12, mcg 0.31 0.55 Niacin, mcg 2500 4000 Niacin, mcg 1860 3300 Folic acid (Folacin), mcg 23 35 Folic acid (Folacin), mcg 16.8 28 Pantothenic acid, mcg 840 1190 Pantothenic acid, mcg 630 960 Biotin, mcg 2.7 4.1 Biotin, mcg 2 3.3 Vitamin C (Ascorbic acid), mg 14.6 20 Vitamin C (Ascorbic acid), mg 10.9 16.7 Minerals Minerals Calcium, mg 75 118 Calcium, mg 101 145 Phosphorus, mg 42 65 Phosphorus, mg 56 80 Magnesium, mg 3.8 4.3 Magnesium, mg 5.1 5.3 Iron, mg 0.88 1.54 Iron, mg 1.18 1.9 Zinc, mg 0.77 1.11 Zinc, mg 1.04 1.37 Manganese, mcg 4.9 8.7 Manganese, mcg 6.5 10.7 Copper, mcg 62 82 Copper, mcg 83 101 Iodine, mcg 16.2 14.8 Iodine, mcg 22 18.4 Selenium, mcg 2.2 2 Selenium, mcg 2.9 2.5 Sodium, mg 38 46 Sodium, mg 51 57 Potassium, mg 66 79 Potassium, mg 89 98 Chloride, mg 65 72 Chloride, mg 88 88 Additional Nutrients Linoleic acid, mg 730 730 Linoleic acid, mg 540 590 Linolenic acid, mg 54 60 Linolenic acid, mg 40 48 ARA, mg 32 38 ARA, mg 24 31 DHA, mg 21 24 DHA, mg 15.6 19.2

154 Enfamil® Liquid Human Milk Fortifier Standard Protein 155 0.36 0.6 1.58 2.2 4.27.8 4.8 7.6 3.8 4.3 3.3 5.3 2.8 5 2.20.85 3.4 1.52 0.62 0.97 4.8 8.6 1.82 1.67 15.6 19.2 46 54 24 31 55 30 73 116 82 133 75 81 41 63 8987 88 24 158 35 55 75 13.629 12.5 38 64 78 51 59 16 21 13.3 13.3 22 22 5 mL 5 mL 620 670 165 260 102 167 660 1090 620 960 0.74 0.81 50 mLmL 25 2000 3400 mg

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, Vitamin B Ribofl Biotin Pantothenic acid Vitamin B Niacin Folic acid DHA ARA Linolenic acid Additional Nutrients Linoleic acid Phosphorus Magnesium Minerals Calcium Vitamin D Vitamin E Iron Zinc Vitamins/Other Nutrients Vitamin A activity Term human milk Term Protein ELHMF Standard Nutrients per 100 Cal per 100 Nutrients ~Cal/fl TERM TERM Final volume Vitamin K Thiamin Energy Choline Inositol Vitamin C Manganese Copper Protein Iodine Selenium Sodium Water Fat Carbohydrate Potassium Chloride References Composition 1. Data on fi le, Mead Johnson Nutrition, September 7, 2010. Ingredients: Water, whey protein isolate hydrolysate (milk), medium chain 2. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11–14. triglycerides (MCT oil), maltodextrin, soy oil, and less than 2%: Mortierella alpina oil¶, Schizochytrium sp. oil#, calcium citrate, calcium phosphate, potassium citrate, calcium chloride, sodium citrate, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, pectin, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin D3.

¶ A source of arachidonic acid (ARA). # A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil Liquid Human Milk Fortiﬁ er Standard Protein contains milk and soy.

CAUTION: Nutritionally incomplete. To be used only under the supervision of a physician.

156 Enfamil

Notes

® Liquid Human Milk Fortifier Standard Protein

157 ® Enfamil • Commercially sterile, single-dose packaging meets AND and CDC feeding preparation guidelines Human Milk • Clinically proven safe and well tolerated in preterm infants1-3,‡: Fortifier ° No statistical differences in conﬁ rmed NEC (3%), sepsis (12%) or serious adverse events than Enfamil HMF Powder1 Acidified Liquid • Shown to signiﬁ cantly improve DHA and ARA status in preterm infants compared to Enfamil HMF Powder4

* Based on the gold standard for clinical research: randomized, prospective, blinded, controlled clinical trials. Description/Indication † When mixed as directed: EHMFAL + preterm human milk (1 vial + 25 mL). Enfamil Human Milk Fortifi er Acidifi ed Liquid is to be added to expressed ‡ Studies used EHMFAL vs. Enfamil HMF Powder. breast milk for feeding premature or low-birth-weight infants. It provides enriched nutrition needed by these special babies while still allowing them to receive their mother’s milk. Enfamil Human Milk Fortifi er Acidifi ed Liquid increases the levels of protein, energy, calcium, phosphorus, iron, vitamin D Product Form and other nutrients, producing a diet more suited to the nutritional needs of Enfamil Human Milk Fortifi er Acidifi ed Liquid is available in an ultra- the rapidly growing premature infant. concentrated liquid. For ordering information, please refer to page 298.

Product Features • Clinically proven to promote growth, including linear growth1,*: ° ~21% more protein than Enfamil® Human Milk Fortiﬁ er Powder† ° Helps premature infants achieve signiﬁ cantly higher achieved weight, length, head circumference and linear growth rate than Enfamil HMF Powder with the same volume intake1 • 4 g of protein per 100 Cal when mixed with preterm human milk† • Protein source is partially hydrolyzed whey protein

158 Enfamil® Human Milk Fortifier Acidified Liquid 159 § ¶ # ed Preterm ed No Breast Milk Breast Per 100 CalPer 100 1 Vial + 25 mL) 1 Fortiﬁ

§ 17.7 per 4 vials . 78 80 6 (97 Cal) Preterm Breast Milk Preterm Breast 4 Vials Plus 100 mL Vials 4 5 3.4 3.9 4 0.96 1.33 1.37 1.76 1.85 1.91 1.84 5.1 5.3 31 34 35 63 10 10.4 10.7 28 86 89 45 95 98 60 98 101 27 55 57 15.2 20 21 EHMFAL + Preterm Human Milk ( EHMFAL 920 1150 1190 116 141 145 (30 Cal) (mOsm/4 vials)

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§ – – 326 ~4.3 ~4.3 ~4.7 (97 Cal) Per 1 VialPer 1 Vials Per 4 5 Preterm Breast Milk Preterm Breast 4 Vials Plus 100 mL Vials 4 5.7 7.7 7.9 2.22.3 3.8 5.8 4 6 0.64 0.66 0.68 5.6 6 6.2 15.1 104 107 <1.2 7.9 8.1 230 710 730 184 193 200 260 290 300 188 200140 210 146 151 (30 Cal) 1160 1210 1250 3700 3900 4000 (mOsm/100 Calories) mcg

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, (% Calories) Carbohydrate Linoleic acid Thiamin Potential Renal Solute Load Fat Vitamin A Vitamins/Other Nutrients Vitamins/Other Ribofl Niacin Vitamin B Vitamin K Osmolality pH Fat Nutrient DensityProtein Vials (30 Cal) Per 4 Vials (30 Cal) Per 4 NUTRIENT FACTS Carbohydrate Vitamin D Protein Vitamin E Vitamin B (Normal Dilution)Vials Per 4 NUTRIENTS Water § Calculated human breast milk compiled from multiple published studies; protein value used for preter using values for preterm § || When mixed at normal dilution, 1 vial to 25 mL preterm human milk. When mixed at dilution, normal || 31 mOsm/120 mL when 4 vials added to 100 mL preterm human milk. ¶ increases osmolality by approximately 36 mOsm/kg water. EHMFAL When added to human milk as recommended, # PRETERM HUMAN MILK CALORIC RECIPES PRETERM HUMAN MILK CALORIC RECIPES Nutrients per 100 Cal Nutrients per 100 mL ~Cal/fl oz 22 24 ~Cal/mL 0.74 0.81 Preterm human milk 50 mL 25 mL Preterm human milk 50 mL 25 mL ++++++ EHMFAL concentrate 5 mL 5 mL EHMFAL concentrate 5 mL 5 mL Final volume, mL 55 30 Final volume, mL 55 30 Energy, Cal 100 100 Energy, Cal 75 81 Protein, g 3.3 4 Protein, g 2.5 3.2 Fat, g 5.7 6 Fat, g 4.2 4.8 Carbohydrate, g 9.3 8.1 Carbohydrate, g 6.9 6.6 Water, g 118 107 Water, g 88 87 Vitamins/Other Nutrients Vitamins/Other Nutrients Vitamin A activity, IU 770 1250 Vitamin A activity, IU 570 1010 Vitamin D, IU 124 210 Vitamin D, IU 93 167 Vitamin E, IU 3.9 6.2 Vitamin E, IU 2.9 5 Vitamin K, mcg 5.9 7.9 Vitamin K, mcg 4.4 6.4 Thiamin (Vitamin B1), mcg 123 200 Thiamin (Vitamin B1), mcg 92 161 Ribofl avin (Vitamin B2), mcg 191 300 Ribofl avin (Vitamin B2), mcg 143 240 Vitamin B6, mcg 93 151 Vitamin B6, mcg 69 122 Vitamin B12, mcg 0.41 0.68 Vitamin B12, mcg 0.31 0.55 Niacin, mcg 2500 4000 Niacin, mcg 1880 3300 Folic acid (Folacin), mcg 23 35 Folic acid (Folacin), mcg 17 28 Pantothenic acid, mcg 840 1190 Pantothenic acid, mcg 630 960 Biotin, mcg 2.7 4 Biotin, mcg 2 3.3 Vitamin C (Ascorbic acid), mg 14.6 21 Vitamin C (Ascorbic acid), mg 10.9 16.7 Minerals Minerals Calcium, mg 101 145 Calcium, mg 75 118 Phosphorus, mg 56 80 Phosphorus, mg 42 65 Magnesium, mg 5.1 5.3 Magnesium, mg 3.8 4.3 Iron, mg 1.18 1.91 Iron, mg 0.88 1.54 Zinc, mg 1.04 1.37 Zinc, mg 0.77 1.11 Manganese, mcg 6.5 10.7 Manganese, mcg 4.9 8.7 Copper, mcg 83 101 Copper, mcg 62 82 Iodine, mcg 22 18.4 Iodine, mcg 16.2 14.8 Selenium, mcg 2.9 2.5 Selenium, mcg 2.2 2 Sodium, mg 51 57 Sodium, mg 38 46 Potassium, mg 89 98 Potassium, mg 66 79 Chloride, mg 88 89 Chloride, mg 65 72 Additional Nutrients Additional Nutrients Linoleic acid, mg 730 730 Linoleic acid, mg 540 590 Linolenic acid, mg 54 60 Linolenic acid, mg 40 48 ARA, mg 32 38 ARA, mg 24 31 DHA, mg 21 24 DHA, mg 15.6 19.2

160 Enfamil® Human Milk Fortifier Acidified Liquid 161 0.36 0.6 1.84 2.6 4.27.5 4.8 7.2 3.8 4.3 0.43 0.59 3.3 5.3 2.8 5 2.20.85 3.4 1.52 0.62 0.97 4.8 8.6 1.82 1.67 2.5 2.3 15.6 19.2 46 54 24 31 55 30 73 116 82 133 75 81 41 63 8724 158 35 89 88 55 75 13.629 12.5 38 64 78 51 59 16 21 14.5 13.3 24 22 5 mL 5 mL 620 670 164 260 102 167 660 1090 620 960 0.74 0.81 50 mLmL 25 2000 3400 mg

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, Vitamin B Ribofl Vitamin B Biotin Pantothenic acid Niacin Folic acid DHA ARA Linolenic acid Linoleic acid Additional Nutrients Phosphorus Magnesium Calcium Minerals Vitamin D Vitamin E Iron Zinc Vitamins/Other Nutrients Vitamin A activity Term human milk Term concentrate EHMFAL Nutrients per 100 Cal per 100 Nutrients ~Cal/fl TERM TERM Final volume Vitamin K Thiamin Energy Total nucleotides Total Choline Inositol Vitamin C Manganese Copper Protein Iodine Selenium Sodium Minerals, Minerals, Fat Carbohydrate Water Potassium Chloride References Composition 1. Moya F, Sisk PM, Walsh KR, et al. A new liquid human milk fortifi er and linear growth in preterm Ingredients: Water, whey protein isolate hydrolysate (milk), medium chain infants. Pediatrics. 2012;130:e928-935. 2. Kurada S, Kamat M, Khilfeh M, et al. Comparison of breast milk with powdered human milk triglycerides (MCT oil), vegetable oil (soy and high oleic sunfl ower oils) and fortifi er (PHMF) and Liquid Human Milk Fortifi er (LHMF) on nutrition and growth parameters less than 2%: Mortierella alpina oil**, Crypthecodinium cohnii oil††, pectin, of VLBW infants. Presented at: Pediatric Academic Societies Annual Meeting; May 3-6, 2014; Vancouver, Canada. Abstract 3845.687. vitamin A palmitate, vitamin E acetate, vitamin D3, vitamin K1, thiamin 3. Mayberry L, Wolf S. Tracking nutritional protein management in the preterm infant using Vermont- hydrochloride, ribofl avin, vitamin B6 hydrochloride, vitamin B12, niacinamide, Oxford benchmarks. FASEB J. 2014;28(1 suppl):LB318. folic acid, calcium pantothenate, biotin, ascorbic acid, calcium citrate, 4. Berseth CL, Harris CL, Wampler JL, et al. Liquid human milk fortifi er signifi cantly improves calcium phosphate, cupric sulfate, sodium citrate, potassium citrate, calcium docosahexaenoic and arachidonic acid status in preterm infants. Prostaglandins Leukot Essent Fatty Acids. 2014;91:97-103. chloride, citric acid, ferrous sulfate, magnesium phosphate, zinc sulfate. 5. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute in infancy. J Pediatr. 1999;134:11-14. ** A source of arachidonic acid (ARA). 6. Data on fi le, Mead Johnson Nutrition, September 7, 2010. †† A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil® Human Milk Fortiﬁ er Acidiﬁ ed Liquid contains milk and soy.

CAUTION: Regarding use in extremely low-birth-weight infants (ELBW— 1 kg or less): Hypercalcemia has been reported in some of these infants on full enteral feeds of mother’s milk supplemented with human milk fortiﬁ ers. CAUTION: Nutritionally incomplete: To be used only under the supervision of a physician.

162 Oral Electrolyte Solutions Product Form ® Enfamil Enfamil Enfalyte is available in ready-to-use 2 ﬂ oz and 6 ﬂ oz Nursette® Enfalyte® bottles. For ordering information, please refer to page 297.

Composition Description/Indicationescriptio Per 100 mL mEq mmole Enfamilfamil EnEnfalytefalyte iiss an oral electrolyte solution designed for infants and Sodium 55 childrenildren to qquicklyuickly replace electrolytes and water that may be lost during Chloride 4.5 4.5 vomiting and diarrhea to help restore hydration. Citrate 3.3 1.1 Potassium 2.5 2.5 Corn Syrup Solids 3 g Calories 12.6 Calories per 100 mL/3.7 Calories per fl oz Product Features NOTE: Enfamil Enfalyte Oral Electrolyte Solution has an osmolality of approximately • Formulated with an optimal balance of carbohydrates, from corn syrup 160 mOsm/kg of water. solids, to promote fl uid and electrolyte absorption one might lose from vomiting and diarrhea Ingredients: Ready To Use Unfl avored (2 fl oz Nursette): Water, corn syrup • Ready to use; no mixing or dilution required solids, salt (sodium chloride), potassium citrate, sodium citrate, citric acid. • Available in unfl avored and cherry fl avor that is made with natural Ingredients: Ready To Use Cherry Flavor (6 fl oz Nursette): Water, corn fruit fl avor syrup solids, salt (sodium chloride), potassium citrate, natural fl avor, sodium • Balanced levels of electrolytes not found in soft drinks and juices citrate, citric acid. • Low osmolality (160 mOsm/kg water) • Suitable for someone with lactose intolerance • Kosher (Pareve ingredients; manufactured on dairy equipment)

164 Enfamil® Enfalyte® 165 When severe is recommended ® . 2004;114:507. . Enfalyte Pediatrics ® . 2003;52(RR-16):1-16. 2003;52(RR-16):1-16. . Enfamil MMWR Recomm Rep Do not mix with infant formula, milk, fruit juices or other milk, Do not mix with infant formula,

This product should be used only as directed by the baby’s only as directed by the baby’s This product should be used

rehydration, maintenance, and nutritional therapy. and nutritional therapy. maintenance, rehydration, and maintenance, oral rehydration, Managing acute gastroenteritis among children: nutritional therapy. oral Managing acute gastroenteritis among children: Academy of Pediatrics. American for the Centers for Disease Control and Prevention. et al. Bresee JS, Glass R, King CK, for all ages of children and adults. Older children and adults should children and Older for all ages adults. of children and of diarrhea. diet during episodes their normal continue amount indications, clinical be adjusted on the basis of Intake should patients’ water usual factors. intake and other relevant uid loss, of fl with Other Fluids: in Conjunction Enfalyte Enfamil fl uid losses or accumulated defi cits require parenteral fl uid therapy, uid therapy, parenteral fl cits require or accumulated uid losses defi fl child or adult is the infant, may be given orally while Enfamil Enfalyte uid parenteral therapyalso receiving of the estimated to supply part fl attention Careful amount of Enfamil Enfalyte must be paid to the needs. After emergency uid intake. to the total fl consumed as it contributes (orally) may be used. Enfamil Enfalyte alone needs have been met, they may be introduced Once the patient can tolerate foods, regular Enfalyte correspondingly decreased. and the amount of Enfamil WARNING: use. Not for parenteral (I.V.) electrolyte-containing liquids. CAUTION: or diarrhea continues beyond If vomiting or fever is present, doctor. doctor. the baby’s consult 24 hours, References For Older Children and Adults: Children and For Older 1. 2. In 2004, the American Academy American the In 2004, the Centers for Disease Control and the Centers for Disease Control 1 that children and nursing infants who have diarrhea 2

necessary following diarrhea. as soon as they have been rehydrated. Lactose-free diets are rarely as soon as they have been rehydrated. infants who require rehydration should be fed age-appropriate diets Nursing infants should continue nursing on demand. Formula-fed Formula-fed Nursing infants should continue nursing on demand. and clinical status infant. of the and clinical parents on appropriate intakes based on the weight, rate of fl uid loss rate of fl parents on appropriate on the weight, intakes based in addition to replacement for ongoing losses. Physicians should guide ongoing losses. in addition to replacement for fl uid defi cit within 2–4 hours using 50–100 mL per kilogram of weight, hours using 50–100 mL per kilogram of weight, cit within 2–4 uid defi fl moderate dehydration should include replacement of their estimatedmoderate dehydration should include given twice as much. The dietary management of children with mild or given twice as much. watery children should be stool or for each episode of vomiting; larger of ongoing losses with 2–4 fl oz of oral rehydration fl uids for each oz of oral rehydration fl fl of ongoing losses with 2–4 than 10 kg (22 pounds) with minimal dehydration includes replacement minimal dehydration than 10 kg (22 pounds) with includes diets. The dietary management of dehydration in children weighing less diets. and who are not dehydrated should continue to be fed age-appropriate Prevention’s report Prevention’s For Infants and Young Children: and Young For Infants contraindicated. endorsed (AAP) of Pediatrics diarrhea, and to rule out conditions where oral rehydration and to rule out conditions would be diarrhea, medical evaluation conditions presenting with to check for other serious symptoms of dehydrationsymptoms of status or a change in mental should have a diarrhea or persistent vomiting, and a caregiver’s report of signs and and a caregiver’s vomiting, diarrhea or persistent children, children with dysentery (blood or mucus in stools), signifi cant signifi children with dysentery in stools), (blood or mucus children, Young children or those with other underlying conditions, febrile conditions, with other underlying or those children Young Administration Product Form Enfamil® Enfamil Enfalyte is available in ready-to-use 32 fl oz bottles. For ordering information, please refer to page 297. Enfalyte®

Composition mEq Description/Indication Per 32 fl oz Per 100 mL Sodium 47 5 Enfamil Enfalyte is a mild fruit-fl avored oral electrolyte solution designed to Chloride 43 4.5 quickly replace electrolytes and water that may be lost during vomiting and Citrate 31 3.3 diarrhea to help restore hydration. Potassium 24 2.5 Corn Syrup Solids 3 g per 100 mL Calories 12.6 Calories per 100 mL/3.7 Calories per fl oz

Product Features This product should be used only as directed by a doctor. If vomiting • Formulated with an optimal balance of carbohydrates and or fever is present, or diarrhea continues beyond 24 hours, consult electrolytes to promote fl uid and electrolyte absorption a doctor. • Balanced levels of electrolytes not found in soft drinks and juices Ingredients: Ready To Use (Cherry Splash Flavor): Water, corn syrup • Clear formulation—no artifi cial fl avors, colors or sweeteners solids, natural fl avor, potassium citrate, salt (sodium chloride), citric acid, • Ready to use; no mixing or dilution required sodium citrate. • Low osmolality (200-210 mOsm/kg water) Ingredients: Ready To Use (Mixed Fruit Flavor): Water, corn syrup solids, • Suitable for someone with lactose intolerance potassium citrate, salt (sodium chloride), natural fl avor, sodium citrate, • Kosher (Pareve ingredients; manufactured on dairy equipment) citric acid. WARNING: Do not mix with infant formula, milk, fruit juices or other electrolyte-containing liquids. CAUTION: Use under medical supervision. Ready to use. Do not add water or dilute. 166 Hospital Feeding Systems Hospital Feeding Routine Systems

Mead Johnson is committed to advancing the science of pediatric nutrition by providing a comprehensive line of hospital products and accessories to give infants an excellent start in life. Enfamil NeuroPro™ Enfamil® 24 Enfamil NeuroPro Infant with Iron 24 Cal/fl oz Infant with Iron ® NURSETTE BOTTLES 20 Cal/fl oz 2 fl oz 20 Cal/fl oz 2 fl oz #166802 6 fl oz Vacuum-sealed, disposable Nursette bottles #171601 #171901 for oral/enteral feeding are commercially sterile and convenient. Nursette bottles are Human Milk Fortification easy to open and designed to be used with Enfamil® ready-to-use (40 mm) screw-type disposable nipple units described below.

Nursette bottles available: Disposable 2 fl oz bottles, conveniently packed, 48 per case and 6 fl oz bottles conveniently packed, 24 per case. The bottles are made of polypropylene and carry the #5 recycling code. They are not ® ® ® ® made with BPA or phthalates including DEHP. Enfamilfamil HumHumanan MMilkilk Enfamilnfamil HumHumanan MMilki Enfamil Human Milk Fortifi er Enfamil Human Milk Fortifi er High Protein Fortifi er Standard Protein Acidifi ed Liquid Fortifi er Powder 5.5 fl oz 5.5 fl oz 100 vials/carton, 100 units/carton, #178301 #178201 2 cartons/case 2 cartons/case #146301 #201418

168 Hospital Feeding Systems 169 ™ 6 fl oz 6 fl #129601 Enfaport 30 Cal/fl oz 30 Cal/fl 6 fl oz 6 fl #429704 20 Cal/fl oz 20 Cal/fl Nutramigen 2 fl oz 2 fl #143401 Pregestimil 24 Cal/fl oz 24 Cal/fl ® ® 2 fl oz 2 fl 2 fl oz 2 fl #143701 #143301 20 Cal/fl oz 20 Cal/fl Nutramigen 20 Cal/fl oz 20 Cal/fl Pregestimil ™ ® 2 fl oz 2 fl #124902 EnfaCare 22 Cal/fl oz 22 Cal/fl Enfamil NeuroPro Premature ® 2 fl oz 2 fl #156501 30 Cal/fl oz 30 Cal/fl Enfamil 6 fl oz 6 fl #129501 20 Cal/fl oz 20 Cal/fl Enfamil Gentlease Premature ® 2 fl oz 2 fl #156601 24 Cal/fl oz 24 Cal/fl High Protein ™ Enfamil 2 fl oz 2 fl #145301 20 Cal/fl oz 20 Cal/fl Enfamil A.R. Premature ® ® 2 fl oz 2 fl #156301 24 Cal/fl oz 24 Cal/fl Enfamil ProSobee ® 2 fl oz 2 fl #144901 20 Cal/fl oz 20 Cal/fl Enfamil Premature ® 2 fl oz 2 fl ® #156401 20 Cal/fl oz 20 Cal/fl Enfamil Gentlease ® 2 fl oz 2 fl #146401 20 Cal/fl oz 20 Cal/fl Enfamil DHA & ARA DHA & ®

2 ﬂ oz 2 ﬂ #426201 Supplement

Enfamil

NICU and Specialty Products NICU and Specialty Feeding Solution Formulas Solution Formulas Feeding Allergy Solution Formulas Oral Electrolyte Grad-U-Feed Nurser: The Grad-U-Feed Nurser holds 60 mL of feeding and designed for measured feedings in neonatal intensive care nurseries. The Grad-U-Feed Nurser is packaged sterile by gamma irradiation. The nursers are made of polypropylene. Nipple Grad-U-Feed Grad-U-Feed units are not provided with Grad-U-Feed Nurser Nurser with Cap 100/case 100/case ® Nursers. Enfamil nipples may be used. There #006806 #006804 are 100 Grad-U-Feed Nursers per case.

Enfamil® Enfalyte® Enfamil Enfalyte Unfl avored Oral Electrolyte Cherry Flavored Oral Grad-U-Feed® Caps: Solution 2 fl oz Electrolyte Solution 6 fl oz #167101 #167503 These white plastic caps are designed to fi t the Grad-U-Feed Nurser with easier close and help Grad-U-Feed Caps Grad-U-Feed Nurser prevent leakage. Caps are packaged sterile by 200/case with Cap - 2 pack Accessories gamma irradiation. Bulk packaged caps are #006807 50x2 packs #006805 Mead Johnson distributes plastic bottles, Snappies® Breast Milk Storage clean and ready to use. Containers, Grad-U-Feed® Nursers and Cleft Lip/Palate Nursers. All are ready to use and disposable. They are not made with BPA or phthalates Snappies® Breast Milk Storage Containers: including DEHP. Snappies are available in 70 mL (2.3 fl oz) or 35 mL (1.2 fl oz) breast milk storage Plastic Bottles: containers with sterile interiors. Snappies are Convenient plastic bottles hold 8 fl oz and come complete designed as one piece. The fl ip-top cap is with an Enfamil® Standard-Flow Soft nipple, a nipple collar conveniently hinged to the Snappies container and a nipple cover. The bottles are made of polypropylene. so it can be opened and closed with one hand. 35 mL Snappies 70 mL Snappies There are 48 bottles in each case. The bottles are designed to collect, store and Breast Milk Breast Milk Storage Container Storage Container feed expressed breast milk. The bottles can 100/case 200/case withstand freezing temperatures as low as #134807 #134801 Ready-To-Use minus 70° F. Plastic Bottles 48/case #028401 Snappies is a trademark of Thermo Fisher Scientifi c Inc. 170 Hospital Feeding Systems oz mil

a 171 ﬂ

nf 2 ﬂ oz 2 ﬂ 2 EnfamilE #134601 #134601 Glucose in Water Glucose in %% 72/case # #200101 5% Glucose in Water 5 5% Glucose in z Cleft Lip/Palate Nurser Cleft Lip/Palate #594401 200/case o 503

ﬂ 4 3 2 3 NeoMed Transfer Lid NeoMed Transfer mil 1 #1 EnfamilEnfamilEnfa z o ter for Oral Use

450 a Water for Oral Use Water #134501 oz #134503 2 fl oz 32 fl ® bottles. bottles. ® bottles, bottles, ® bottle and a 32 fl oz bottle and a 32 fl ® Transfer Lid: Transfer ® Water for Oral Use comesWater Water 5% Glucose in ® ® The NeoMed Transfer Lid is made with Transfer The NeoMed VI class polypropylene. compatible and meets AND and ASPEN AND and compatible and meets guidelines for aseptic handling of breast ts on cap that It has a reclosable fi milk. all Mead Johnson hospital feeding products, Nursette oz 2 fl including Cleft Lip/Palate Nurser: Cleft Lip/Palate bottle is a squeezable Nurser Lip/Palate The Cleft an elongatedIt comes with nipple oz. that6 fl holds The palate. or cleft lip with a cleft designed for babies The nipple of low-densitynurser is made polyethylene. made plastic and is not is made of surgical-grade Lip/PalateThere are 72 Cleft with natural latex. rubber Nursers per case. Oral Waters: Enfamil The NeoMed Transfer Lid is ENFit Transfer The NeoMed in a Nursette andcomes in a Nursette bottle inprovides 5 grams of glucose 100 mL of water. NeoMed bottle, is commercially sterile and is commercially bottle, intended for oral use only. Enfamil 8 fl oz bottles and Grad-U-Feed 8 fl 11 mL Colostrum1 C Container 10 100/case # #132401 Pacifi er Pacifi #594301 144/case 4 fl oz Breast Milk oz 4 fl Storage Container 250/case #134808 4 S 2 # MAM Preemie Size 2 For infants 900 -1500 g infants 900 For Pacifi er Pacifi ™ #594201 144/case For infants >1400 g For 10 fl oz Breast Milk 10 fl Storage Container 100/case #134809 S # ers: MAM Comfort The MAM Preemie Size 2 Pacifi er is a medical device for premature babies that is The MAM Preemie Size 2 Pacifi MAM pacifi ers are a product of MAM USA Corporation. MAM pacifi Note: It is intended to compensate for the sucking and swallowing only suitable for hospital use. and comply with 16 CFR 1511, does not therefore, It, weaknesses in premature babies. must not be taken home. reduction in autoclaves (up to 273°F/134°C). reduction in autoclaves nasogastric tubing. MAM pacifi ers are suitable for cleaning and germ for cleaning ers are suitable MAM pacifi nasogastric tubing. masks or medical devices. The Preemie Size 2 can be customized to fi t to fi The Preemie Size 2 can be customized masks or medical devices. BPA/BPS-free. The small-shield design leavesThe small-shield design more space for breathing BPA/BPS-free. MAM Pacifi silicone and are ers are a one-piece design made of 100% MAM pacifi Additional Breast Milk Storage Containers: Breast Milk Additional NeoMed® Syringes: NeoMed syringes are ENFit® compatible and meet the 2016 GEDSA position statement recommendations. The syringes are available in 1 mL and 12 mL sizes for enteral and direct oral administration. They support accurate dispensing and are designed with an offset tip, solid plunger and o-ring to NeoMed 1 mL Syringe NeoMed 12 mL Syringe minimize lipid loss. The syringes include a self-righting tip cap necessary for 200/case 200/case adherence to aseptic technique protocols. #594501 #594502 ENFit is a registered trademark of GEDSA. NeoMed is a registered trademark of NeoMed, Inc.

Enfamil® Nipples: Enfamil nipples are ready-to-use, individually wrapped and vented to allow airﬂ ow while the baby is sucking. They are not made with BPA, natural or synthetic rubber latex, or phthalates including DEHP. They will ﬁ t most bottles ® ® with standard or classic-size bottle openings, including our Nursette® bottles, Enfamil Enfamil Enfamil® Standard-Flow Soft Nipple Slow-Flow Soft Nipple Enfamil® Plastic Bottles, Grad-U-Feed® Nursers, Cleft Lip/Palate Nursers and Cross-Cut Nipple 240/case 240/case 240/case ® Snappies . There are 240 nipples per case. #428816 #433905 #428813 NUK is a registered trademark of MAPA, Germany. Coming Soon!

NUK® Orthodontic Enfamil® Slow-Flow Nipple Extra Slow-Flow Soft Nipple 240/case 240/case #210504 #433912

172 HospitalEnfamil PREMIUM Feeding Systems® Newborn 173173 owder) #3006-W3 Sample Kit (P ® Wonder Wonder Bag #3006-Z1 ® – Powder – Liquid #3006-U4 #3006-U3 EnfaCare ™ – EnfaCare Kit#3006-D1 Wonder Wonder Bag Wonder Bag ® ® Wonder Bag resources and offers is customized with helpful Wonder ®

Enfamil NeuroPro NICU Welcome NICU Welcome Enfamil NICU Kits Available Enfamil COMING SOON tailored to the feeding method mom chooses. tailored to the Enfamil Created for both breastfeeding and formula-feeding moms, the Created moms, and formula-feeding both breastfeeding for STARTER KITS STARTER • A Natural Defense® Dual Prebiotic blend of GOS (galactooligosaccharides) and PDX (polydextrose) at 4 g/L is designed to: ® ° Support immune health by promoting the growth of benefi cial Enfamil 24 bacteria (bifi dobacteria and lactobacilli)4,5 ° Promote soft stools similar to those reported for breastfed infants6 • 24 Cal/fl oz formulation • Easy-to-digest, 80:20 whey-to-casein ratio patterned after early breast milk7,§ Description/Indication • 75 IU of vitamin D per 100 Cal Enfamil 24 is a 24 Cal/fl oz, milk-based, iron-fortifi ed formula for full-term • Kosher infants who require increased caloric density. Enfamil 24 has DHA in amounts clinically demonstrated to foster cognitive development through * Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without 5 years of age and has an 80:20 whey-to-casein ratio patterned after early DHA and ARA; studied before the addition of prebiotics. † Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard breast milk. Enfamil 24 has the same trusted nutritional source as Enfamil deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women1. PREMIUM® Newborn. ‡ Enfamil 24 has not been shown superior to the leading competitor in supporting mental, visual and immune system development. The level of DHA in Similac Pro-Advance™ is ~0.15% of total fatty acids. § Based on whey-to-casein ratio 3-5 days after lactation begins. Product Features • DHA at the clinically proven* amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average1,†, and double the Product Form amount found in the leading competitor’s product‡: Enfamil 24 is available in ready-to-use liquid. For ordering information, ° Clinically proven* to support mental, visual and immune system please refer to page 297. development ° Clinically shown to improve long-term cognitive outcomes through 5 years of age2,* ° Shown to improve respiratory health through the fi rst 3 years of life when infants were fed through 12 months3,*

174 Enfamil® 24 175 § oz Per 100 mL Per 100 No 15.4 320 370 1 0.81 81.8 6.5 1.46 6 4.9 2.8 2.3 3 2.4 7843 63 35 24 19.5 63 51 12 9.7 15 12.2 27 22 15 12.2 75 61 (4.2 ﬂ oz) (4.2 ﬂ 108 88 8 Per 100 Calories Per 100 (mOsm/100 mL) mg

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(% Calories) , Thiamin Vitamin E Vitamin K Vitamins/Other Nutrients Vitamins/Other Vitamin A Vitamin D Water Carbohydrate Carbohydrate Carbohydrate Potential Renal Solute Load Linoleic acid Ribofl Folic acid Pantothenic acid Niacin Fat Vitamin B Fat Vitamin B Whey:Casein Ratio Protein NUTRIENT FACTS Nutrient Density 24 Calories/fl Protein (Normal Dilution) NUTRIENTS § At 24 Cal/fl oz (0.81 Cal/mL). 24 Cal/fl At § References Composition 1. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in Ingredients: Ready To Use (2 fl oz Nursette® bottle): Water, nonfat milk, human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464. 2. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on lactose, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412. || oils) and less than 2%: whey protein concentrate, galactooligosaccharides , 3. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic polydextrose||, Mortierella alpina oil¶, Schizochytrium sp. oil#, potassium manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906. citrate, calcium phosphate, calcium chloride, magnesium phosphate, 4. Scalabrin D, Mitmesser SH, Welling GW, et al. New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifi dogenic effect in young infants. J Pediatr Gastroenterol Nutr. sodium chloride, calcium carbonate, ferrous sulfate, sodium citrate, 2012;54:343-352. zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, 5. Salminen S, Endo A, Isolauri E, et al. Early gut colonization with lactobacilli and staphylococcus in sodium selenite, mono- and diglycerides, ascorbic acid, sodium ascorbate, infants: the hygiene hypothesis extended. J Pediatr Gastroenterol Nutr. 2016;62:80-86. 6. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed ribofl avin, thiamin hydrochloride, vitamin B6 hydrochloride, folic acid, infants. J Pediatr Gastroenterol Nutr. 2007; 44:359-364. vitamin K1, vitamin B12, vitamin D3, biotin, soy lecithin, carrageenan, choline 7. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milk. Acta chloride, inositol, nucleotides (cytidine 5’-monophosphate, disodium uridine Paediatr. 1992;81:107-112. 8. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 1999;134:11-14. 5’-monophosphate), taurine, L-carnitine.

|| A type of prebiotic. ¶ A source of arachidonic acid (ARA). # A source of docosahexaenoic acid (DHA).

Potential Allergens Enfamil® 24 contains milk and soy.

176 Toddler Formulas Enfagrow • Calcium and vitamin D to support bone development ™ • Has other important nutrients like zinc that are important for PREMIUM toddler development Toddler • No preservatives • No artifi cial sweeteners ® Transitions • No artifi cial fl avoring • No artifi cial colors • Non-GMO* Description/Indication • Kosher Enfagrow PREMIUM Toddler Transitions is a 20 Cal/fl oz complete infant formula for toddlers 9–18 months who are transitioning from infant formula * Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For or breast milk. Enfagrow PREMIUM Toddler Transitions has DHA, iron, more information, visit enfamil.com/nonGMO. vitamin C, vitamin E and 26 other nutrients to help support growth and development. When toddlers transition to new foods, ensuring balanced nutrition can become more of a challenge. Enfagrow PREMIUM Toddler Transitions helps make sure toddlers get important nutrients they might still need. Product Forms Enfagrow PREMIUM Toddler Transitions is available in powder. For ordering information, please refer to page 296.

Product Features • Nutrition designed for older infants and toddlers 9–18 months • Triple Health Guard® blend: ° DHA and iron to help support toddler brain development1-8 ° Prebiotics and vitamins and minerals designed to help support immune health ° 30 nutrients for growth

178 Enfagrow PREMIUM™ Toddler Transitions® 179 oz No 17.6 270 240 9 8 5.41.5 1.011 0.68 40 7.6 5.1 6 4.1 30 32 15.2 2.8 1.89 14.1 80 54 400 12 8.124 16.2 61 121 15 10.1 76 36 24 182 10 6.8 51 75 51 380 130 88 660 200 132 980 130 88 660 (mOsm/100 mL) mg

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180 Enfagrow PREMIUM

Notes

™ Toddler Transitions

181 ® Enfagrow Product Features Toddler • Nutrition designed for older infants and toddlers 9–18 months ® • Similar to Enfamil PREMIUM Gentlease; designed for toddlers Transitions experiencing fussiness and gas: Gentlease® ° A special blend of easy-to-digest proteins that have been partially broken down ° A blend of carbohydrates that has a reduced amount of lactose† Description/IndicationDescription/Ind designed for toddlers with fussiness or gas • Triple Health Guard® blend: Enfagrow Toddler Transitions Gentlease is a 20 Cal/fl oz complete infant and toddler formula for toddlers 9–18 months who are transitioning from ° DHA, also found in breast milk, that supports brain and eye infant formula or breast milk. Enfagrow Toddler Transitions Gentlease can development2-9 be helpful in situations where Enfamil PREMIUM® Gentlease® was used ° Iron to support mental development 1 in infancy and when sensitivity appears to continue. Enfagrow Toddler ° Has vitamins C and E to help support toddlers’ developing Transitions Gentlease has an easy-to-digest protein blend with a whey-to- immune systems * casein ratio of 60:40 that has been partially broken down. It also has 25% • Calcium and vitamin D to support bone development of the lactose of a routine, milk-based infant and toddler formula. • Has other key nutrients like zinc that are important for Enfagrow Toddler Transitions Gentlease has DHA, iron, vitamin C, vitamin E toddler development and over 20 other nutrients to help support growth and development. When • No preservatives toddlers transition to new foods, ensuring complete nutrition can become • No artifi cial sweeteners more of a challenge. Enfagrow Toddler Transitions Gentlease helps make • No artifi cial fl avoring sure toddlers get the nutrients they might still need. • No artifi cial colors • Kosher

* Prior to partial hydrolysis. † Approximately ½ the lactose of a routine, milk-based infant and toddler formula.

182 Enfagrow® Toddler Transitions® Gentlease® 183 oz 17.8 No 230 210 10 8 5.41.5 1.011 0.68 40 7.5 5 6 4.1 30 32 14.9 2.8 1.89 13.9 80 54 400 12 8.124 16.2 60 119 15 10.1 75 40 27 200 15 10.1 75 75 51 370 130 88 650 200 135 990 130 88 650 (mOsm/100 mL) mg

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, , Lactose-free Osmolarity Osmolality Potential Renal Solute Load Iron Zinc Magnesium Phosphorus Minerals Calcium Inositol Chloride Potassium Sodium Vitamin C Choline Biotin Manganese Copper Selenium Iodine oz 20 Calories/fl 42 48 10 26 for current information. see product label Please to change. are subject values and ingredients Product nutrient 60:40 10 2 1.359 6.1 9.9 45 5.3 3.6 26 2.61.76 12.9 0.3 0.2 1.49 60 41 300 10.5 7.1 52 16 10.8 80 80 54 400 60 41 300 300 200 1490 133 90 2.4 500 340 2500 800 540 4000 140 95 700 (5 fl oz) (5 fl (500 Cal) Powder oz) (5 fl (500 Cal) Powder 1000 680 5000 (mOsm/100 Calories) mcg

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Potential Allergens Enfagrow Toddler Transitions Gentlease contains milk and soy.

184 Enfagrow

Notes

® Toddler Transitions

® Gentlease

185 ® Enfagrow Product Features Toddler • Nutrition designed for older infants and toddlers 9–18 months of age ® • Similar to Enfamil® ProSobee®; designed for toddlers experiencing Transitions fussiness and gas when soy is preferred Soy • Milk-free and is suitable for someone with lactose intolerance • Triple Health Guard® blend: ° DHA, also found in breast milk, that supports brain and eye Description/Indication development2-9 Enfagrow Toddler Transitions Soy is a 20 Cal/fl oz complete infant and ° Iron to support mental development toddler formula for toddlers 9–18 months who are transitioning from ° Has vitamins C and E to help support toddlers’ developing infant formula or breast milk. Enfagrow Toddler Transitions Soy is designed immune systems to be naturally gentle on a toddler’s digestive system. It’s milk-free and is • Calcium and vitamin D to support bone development suitable for toddlers with milk protein sensitivity—and still provides the • Has other key nutrients like zinc that are important for nutrition toddlers need to grow and develop. Soy-based toddler formulas, toddler development such as Enfagrow Toddler Transitions Soy, are appropriate for use in older • No preservatives infants and toddlers with lactose intolerance and most older infants and toddlers with IgE-mediated allergy to cow’s milk protein1. • No artifi cial sweeteners • No artifi cial fl avoring Enfagrow Toddler Transitions Soy has DHA, iron, vitamin C, vitamin E and • No artifi cial colors over 20 other nutrients to help support growth and development. When • Lactose-free toddlers transition to new foods, ensuring complete nutrition can become more of a challenge. Enfagrow Toddler Transitions Soy helps make sure • Kosher (Pareve ingredients; manufactured on dairy equipment) toddlers get the nutrients they might still need.

186 Enfagrow® Toddler Transitions® Soy 187 oz Yes 20 200 230 10 2 1.351.2 0.81 9.5 5.7 6 4.1 28 32 14.2 2.8 1.89 13.3 11 7.4 52 80 54 380 12 8.124 16.2 57 114 50 34 240 36 24 171 15 10.1 71 75 51 360 130 88 620 195 132 930 120 81 570 (mOsm/100 mL) mg

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Potential Allergens Enfagrow Toddler Transitions Soy contains soy.

188 Enfagrow

Notes

® Toddler Transitions

® Soy

189 Enfagrow NeuroPro™ • Non-GMO† Toddler Nutritional • No artiﬁ cial preservatives, sweeteners or colors Drink • Kosher Natural Milk Flavor and * Based on a behavioral questionnaire as reported by parents of children 2–6 years old, comparing consumption of a milk-based drink with or without MFGM added as an ingredient. Natural Vanilla Flavor † Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For (with other natural ﬂ avors) more information, visit enfamil.com/nonGMO. Description/IndicationDiti Enfagrow NeuroPro Toddler Nutritional Drink is a toddler nutritional drink for toddlers age 1+ years. Enfagrow NeuroPro Toddler is designed as a Product Forms nutritious alternative to milk that complements a toddler’s diet during Enfagrow NeuroPro Toddler Nutritional Drink is available in ready-to-use the transition from breast milk or infant formula. It has 24 total nutrients, liquid. For ordering information, please refer to page 296. including MFGM and DHA, prebiotics, iron, and vitamins C and E to help close nutritional gaps in a toddler’s diet and help support mental development.

Product Features • Milk fat globule membrane (MFGM) and omega-3 DHA to support brain development • Emerging evidence suggests MFGM helps support emotional and behavioral development* • Dual prebiotics, vitamin C and zinc to help support immune health • 24 key nutrients to complement a toddler’s challenging diet • Made with real milk • Available in Natural Milk and Natural Vanilla ﬂ avors

190 Enfagrow NeuroPro™ Toddler Nutritional Drink 191 oz No 2.5 7.5 4 0.75 1 20 23 90 (8 ﬂ oz) (8 ﬂ 250 187 600 100 550 130 2000 (mOsm/100 mL) mg

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‡ Source of MFGM (milk fat globule membrane) and phospholipids. § A type of prebiotic. || A source of docosahexaenoic acid (DHA).

Potential Allergens Enfagrow NeuroPro™ Toddler Nutritional Drink contains milk and soy.

192 Enfagrow NeuroPro™ Toddler Nutritional Drink 193

Notes Enfagrow PREMIUM™ Product Features • Triple Health Guard® blend has DHA to help support the brain, Toddler Next Step™ 22 nutrients to balance the diet, and prebiotics and vitamins to help support immune health: Natural Milk Flavor ° DHA and iron—two building blocks of a toddler’s brain Milk Drink ° Calcium, vitamin D, zinc and 19 other nutrients—to help support (with other natural fl avors) growth and development ® Description/Indication ° Natural Defense Dual Prebiotic blend, designed to help support digestive health Enfagrow PREMIUM Toddler Next Step Natural Milk Flavor is a milk drink • No preservatives for toddlers 1–3 years old that complements their diet as they transition from infant formula or breast milk. Enfagrow PREMIUM Toddler Next • No artifi cial sweeteners Step Natural Milk Flavor is a nutritious alternative to milk. It has 22 total • No artifi cial colors nutrients, such as DHA, prebiotics, iron, and vitamins C and E to help close • Non-GMO† nutritional gaps in toddler’s diets and help support mental development. • Kosher It has a natural milk* taste designed to appeal to a toddler’s tastes, making it easier to deliver the nutrition he might still need. * With other natural fl avors. † Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

Product Forms Enfagrow PREMIUM Toddler Next Step Natural Milk Flavor (with other natural ﬂ avors) is available in powder and convenient ready-to-use liquid. For ordering information, please refer to page 296.

194 Enfagrow PREMIUM™ Toddler Next Step™ 195 28 Powder Per 100 mLPer 100 grams Per 100 9.8 8.5 56 4.9 4.2 wder Ready-to-Drink 12.7 11 72 20 26 (8 fl oz) (8 fl Per 160 CaloriesPer 160 2.7 2.7 1.321.14 7.5 5 5 0.382.1 2.1 2.5 2.5 1.27 1.1 7.2 66 6 6 3.1 3.1 2.7 2.7 17.5 17.8 2.52.6 2.5 2.6 1.23 1.06 1.27 6.9 1.1 7.2 20 26 <1 <1 0.39 0.4 2.2 80 45 39 17.3 220 573010 57 30 10 28 14.7 12.7 24 83 158 38 38 18.6 16.1 106 178500150 210 500 150 87 89 250 74 2.6 210 63 1390 420 360 360 176 152 1000 300 300 147 127 830 160 160 78 68 440 Powder Ready-to-Drink Po (~7 fl oz) (~7 fl 300300 300 300 147 147 127 127 830 830 360 360 176 152 1000 187 187 92 79 520 250 250 123 106 690 30001130 3000 1130 14701270 550 480 8300 3100 for current information. Please see product label change. and ingredients are subject to Product nutrient values mg

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Composition hydrochloride, ribofl avin, vitamin A palmitate, folic acid, biotin, mono- and diglycerides, vitamin D3. Ingredients: Powder: Nonfat milk, corn syrup solids, vegetable oil (palm olein, coconut, soy and high oleic sunfl ower oils) and less than 2%: ‡ A type of prebiotic. galactooligosaccharides‡, polydextrose‡, calcium carbonate, magnesium § A source of docosahexaenoic acid (DHA). phosphate, salt, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, tuna fi sh oil§, niacinamide, ascorbic acid, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, vitamin D3, ribofl avin, folic Potential Allergens acid, biotin, ascorbyl palmitate, vitamin E acetate, vitamin A palmitate, ™ ™ natural fl avor, soy lecithin. Enfagrow PREMIUM Toddler Next Step Natural Milk Flavor contains milk and soy. Ingredients: Ready To Use: Water, nonfat milk, corn syrup solids, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils) and less than 2%: galactooligosaccharides‡, polydextrose‡, Crypthecodinium cohnii References oil§, milk protein concentrate, sugar, potassium chloride, magnesium 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. phosphate, calcium phosphate, potassium citrate, calcium hydroxide, ferrous sulfate, zinc sulfate, cupric sulfate, sodium citrate, natural fl avor, soy lecithin, carrageenan, ascorbic acid, sodium ascorbate, niacinamide, vitamin E acetate, calcium pantothenate, thiamin hydrochloride, vitamin B6

196 Enfagrow PREMIUM™ Toddler Next Step™ 197 EnfagrowE ® Toddler NextN Step™ Product Features ® VanillaV Flavor • Triple Health Guard blend has DHA to help support the brain, 22 nutrients to balance the diet, and prebiotics and vitamins to MMilk Drink help support immune health: (with(w other natural fl avors) ° DHA and iron—two building blocks of a toddler’s brain ° Calcium, vitamin D, zinc and 19 other nutrients—to help support growth and development Description/Indication ® ° Natural Defense Dual Prebiotic blend, designed to help Enfagrow Toddler Next Step Vanilla is a vanilla fl avored milk drink for support digestive health toddlers 1–3 years old that complements their diet as they transition • No preservatives from infant formula or breast milk. Enfagrow Toddler Next Step Vanilla • No artifi cial sweeteners fl avor is a nutritious alternative to milk. Enfagrow Toddler Next Step Vanilla fl avor has 22 total nutrients, such as DHA, prebiotics, iron, and • No artifi cial colors vitamins C and E to help close nutritional gaps in toddler’s diets and • Kosher help support mental development. It has a vanilla* taste designed to appeal to a toddler’s tastes, making it easier to deliver the nutrition he * With other natural fl avors. might still need.

Product Forms Enfagrow Toddler Next Step Vanilla is available in powder and convenient ready-to-use liquid. For ordering information, please refer to page 296.

198 Enfagrow® Toddler Next Step™ Vanilla 199 28 Powder Per 100 mLPer 100 100 grams Per 4.91.23 1.061.27 4.2 6.9 1.1 7.2 3.13.12.7 1.271.1 0.382.1 9.88.5 0.39 0.4 2.7 17.5 7.2 2.1 1.32 1.14 56 2.2 17.8 7.5 2814.7 12.792 2418.6 16.1 83 39 79 106 158 17.3 520 220 7812.711 6887 8974 72 440 2.4 63 420 Powder Ready-to-Drink 550 480123 3100 147 106147 127 690 127 830 830 250147176176 152 210 127 152 1000 1390 830 1000 1470 1270 8300 2.7 6 6 2.5 5 oz) 26 20 2.6 2.5 <1 500 150 300 360 160 210 45 57 30 10 38 (8 ﬂ 300 360 250 187 300 3000 1130 Ready-to-Drink Per 160 CaloriesPer 160 oz) 6 6 5 2.7 2.5 2.6 2.5 20 26 <1 30 38 80 57 10 500 150 360 300 160 178 Powder 300 300 187 360 250 (~7 ﬂ 1130 3000 Per 160 CaloriesPer 160 for current information. Please see product label to change. values and ingredients are subject Product nutrient mg

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Composition pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, ribofl avin, vitamin A palmitate, folic acid, biotin, mono- and diglycerides, natural fl avor, Ingredients: Powder: Nonfat milk, corn syrup solids, vegetable vitamin D3. oil (palm olein, coconut, soy and high oleic sunfl ower oils), sugar, † † galactooligosaccharides , polydextrose and less than 1%: magnesium † A type of prebiotic. phosphate, calcium carbonate, ferrous sulfate, zinc sulfate, manganese ‡ A source of docosahexaenoic acid (DHA). sulfate, cupric sulfate, natural and artifi cial fl avor, tuna fi sh oil‡, ascorbic acid, niacinamide, ascorbyl palmitate, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, ribofl avin, vitamin D3, folic acid, biotin, Potential Allergens vitamin E acetate, vitamin A palmitate, soy lecithin. Enfagrow® Toddler Next Step™ Vanilla contains milk and soy. Ingredients: Ready To Use: Water, nonfat milk, corn syrup solids, vegetable oil (palm olein, soy, coconut and high oleic sunfl ower oils) and less than 2%: galactooligosaccharides†, polydextrose†, Crypthecodinium cohnii oil‡, References milk protein concentrate, sugar, potassium chloride, magnesium phosphate, 1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14. calcium phosphate, potassium citrate, calcium hydroxide, ferrous sulfate, zinc sulfate, cupric sulfate, sodium citrate, soy lecithin, carrageenan, ascorbic acid, sodium ascorbate, niacinamide, vitamin E acetate, calcium

200 Enfagrow® Toddler Next Step™ Vanilla 201 Notes

202 Dietary Supplements ® Enfamil Osmolality D-Vi-Sol® When added to 2 ﬂ oz of infant formula or breast milk, 1 mL of Enfamil D-Vi-Sol Liquid Vitamin D Supplement increases the osmolality by Liquid Vitamin D +110 mOsm/kg water2,*. If the resulting osmolality is higher than desired Supplement for a particular baby, an option is to add 0.5 mL of the supplement to the feeding twice per day.

* A previous formulation was evaluated. Description/Indication Enfamil D-Vi-Sol Liquid Vitamin D Supplement is a supplement for exclusively or partially breastfed infants and toddlers. Product Features • 100% of daily vitamin D as recommended by the AAP, an essential vitamin that helps your baby’s body absorb calcium for strong bones and teeth† Rationale And Special Characteristics • No artifi cial colors or fl avors Enfamil D-Vi-Sol provides 400 IU of vitamin D in one daily serving. • Refrigeration is not required The American Academy of Pediatrics (AAP) recommends 400 IU of • Gluten-free supplemental vitamin D per day beginning in the fi rst days of life for all • Kosher breastfed and partially breastfed infants who do not receive at least 1 L of infant formula per day1. † This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Enfamil D-Vi-Sol does not contain ingredients derived from the most common food allergens: milk, eggs, peanuts, tree nuts, fi sh, shellfi sh, soy or wheat.

204 Enfamil® D-Vi-Sol® Liquid Vitamin D Supplement 205 . 2008;122:1142-1152. . Pediatrics children, and adolescents. and adolescents. children, Wagner CL, Greer FR, et al. Prevention of rickets and vitamin D defi ciency in infants, in infants, ciency and vitamin D defi Prevention of rickets et al. Greer FR, CL, Wagner September 2009. Mead Johnson Nutrition, le, Data on fi 1. 2. References 10 (400 IU)10 (400 100 67 Glycerin, water, polysorbate 80 (emulsifi er), er), polysorbate 80 (emulsifi water, Glycerin, Liquid Vitamin D Supplement is availableVitamin as drops Liquid ® As with all vitamin products, parents should be parents should As with all vitamin products,

As with medicines, keep out of the reach of children. keep As with medicines, , mcg , D-Vi-Sol ®

Nutrient D Vitamin Per 1 mL % DV Infants under age 4 years % DV Children NUTRIENTS cautioned against excessive dosage. cautioned against excessive dosage. Other Ingredients: WARNING: PRECAUTIONS: Composition sodium citrate. avor, natural ﬂ D), citric acid (antioxidant for vitamin

Enfamil Product Form Drops: 1.0 mL daily. 1.0 mL Drops: Usual Daily Serving in 50 mL bottles. For ordering information, please refer to page 297. ordering information, For in 50 mL bottles. ® Enfamil Osmolality Poly-Vi-Sol® When added to 2 ﬂ oz of infant formula or breast milk, 1 mL of Enfamil Poly-Vi-Sol Liquid Multivitamin Supplement increases the osmolality by Liquid Multivitamin +160 mOsm/kg water2,*. If the resulting osmolality is higher than desired Supplement for a particular baby, an option is to add 0.5 mL of the supplement to the feeding twice per day.

* A previous formulation was evaluated. Description/Indication Enfamil Poly-Vi-Sol Liquid Multivitamin Supplement is for infants around 4–6 months of age who are transitioning to solid foods and for toddlers. Product Features • One daily serving of Enfamil Poly-Vi-Sol has 9 vitamins and is fruit fl avored Rationale And Special Characteristics • 100% of daily vitamin D as recommended by the AAP, an essential Enfamil Poly-Vi-Sol has 9 important vitamins in a convenient daily serving. vitamin that helps your baby’s body absorb calcium for strong bones It is an excellent supplement for a child when transitioning to solid foods, and teeth† during growth spurts and for the picky eater. Enfamil Poly-Vi-Sol (without • Helps support a developing immune system† iron) is recommended for children who have suffi cient iron in their diet or • No artifi cial colors or fl avors the possibility of too much. • Enfamil Poly-Vi-Sol is the #1 vitamin drops brand recommended The American Academy of Pediatrics (AAP) recommends 400 IU of by pediatricians supplemental vitamin D per day beginning in the fi rst days of life for all • Refrigeration is not required breastfed and partially breastfed infants who do not receive at least 1 L • Kosher of infant formula per day1.

Enfamil Poly-Vi-Sol does not contain ingredients derived from the most † This statement has not been evaluated by the Food and Drug Administration. This product is common food allergens: milk, eggs, peanuts, tree nuts, ﬁ sh, shellﬁ sh, not intended to diagnose, treat, cure or prevent any disease. soy or wheat.

206 Enfamil® Poly-Vi-Sol® Liquid Multivitamin Supplement 207 . 2008;122:1142-1152. . Pediatrics children, and adolescents. and adolescents. children, Wagner CL, Greer FR, et al. Prevention of rickets and vitamin D defi ciency in infants, in infants, ciency and vitamin D defi Prevention of rickets et al. Greer FR, CL, Wagner September 2009. Mead Johnson Nutrition, le, Data on fi 1. 2. References 0.30.5 100 100 60 56 4 100 67 0.4 100 80 0.3 100 60 5 100 83 50 100 333 250 50 83 10 (400 IU) 100 67 Liquid Multivitamin Supplement is available Liquid Multivitamin Supplement ® Glycerin, water, polysorbate 80 (emulsifi er), er), polysorbate 80 (emulsifi water, Glycerin,

As with all vitamin products, parents should be As with all vitamin products, mcg

mg mg NE ,

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Vitamin B Vitamin B Niacin Ribofl Thiamin Nutrient A Vitamin Per 1 mL % DV Infants under age 4 years % DV Children NUTRIENTS Vitamin D Vitamin E Vitamin C Drops: 1 mL. Drops: Usual Daily Serving page 299. as drops in 50 mL bottles. For ordering information, please refer to ordering information, For as drops in 50 mL bottles. cautioned against excessive dosage. cautioned against excessive dosage. WARNING: PRECAUTIONS: natural fl avor, ferrous sulfate, sulfuric acid (antioxidant for iron), sulfi tes. sulfi sulfuric acid (antioxidant for iron), ferrous sulfate, avor, natural fl Composition Other Product Form Enfamil ® Enfamil Enfamil Poly-Vi-Sol with Iron does not contain ingredients derived from the Poly-Vi-Sol® most common food allergens: milk, eggs, peanuts, tree nuts, fi sh, shellfi sh, soy or wheat. with Iron Enfamil Poly-Vi-Sol with Iron Liquid Multivitamin Supplement does not include Liquid Multivitamin vitamin B12 since it is unstable in a solution that has the concentrations of Supplement iron and vitamin C found in Enfamil Poly-Vi-Sol with Iron Liquid Multivitamin Supplement.

Description/Indication Enfamil Poly-Vi-Sol with Iron Liquid Multivitamin Supplement is recommended Osmolality for infants around 4–6 months of age who are transitioning to solid foods and for toddlers. When added to 2 fl oz of infant formula or breast milk, 1 mL of Enfamil Poly-Vi-Sol with Iron Liquid Multivitamin Supplement increases the osmolality by +160 mOsm/kg water2,*. If the resulting osmolality is higher than desired for a particular baby, an option is to add 0.5 mL of the supplement to the Rationale And Special Characteristics feeding twice per day. Enfamil Poly-Vi-Sol with Iron has 8 important vitamins and iron in a * A previous formulation was evaluated. convenient daily serving and is an excellent supplement for a child’s transition to solid foods, during growth spurts and for the picky eater. Infants may especially require supplemental iron, as around 4–6 months of age, infants begin to lose their iron stores that they have accreted during the third Product Features trimester of pregnancy. • One daily serving of Enfamil Poly-Vi-Sol with Iron has 8 vitamins and iron and is fruit-fl avored The American Academy of Pediatrics (AAP) recommends 400 IU of • 100% of daily vitamin D as recommended by the AAP, an essential vitamin supplemental vitamin D per day beginning in the fi rst days of life for all that helps your baby’s body absorb calcium for strong bones breastfed and partially breastfed infants who do not receive at least 1 L of and teeth† infant formula per day1.

208 Enfamil® Poly-Vi-Sol® with Iron Liquid Multivitamin Supplement 209 with Iron Liquid Multivitamin Supplement is with Iron Liquid Multivitamin ® Glycerin, water, polysorbate 80 (emulsiﬁ er), natural er), polysorbate 80 (emulsiﬁ water, Glycerin,

Poly-Vi-Sol ® Ingredients: Product Form Enfamil Composition Other fl avor, sulfuric acid (antioxidant for iron), sulfi tes. sulfi sulfuric acid (antioxidant for iron), avor, fl available as drops in 50 mL bottles. For ordering information, please ordering information, For available as drops in 50 mL bottles. refer to page 299. Usual Daily Serving 1 mL. Drops: 0.3 100 60 4 100 67 0.4 100 80 0.3 100 60 5 100 83 11 100 157 50 100 333 250 50 83 10 (400 IU) 100 67 † is the #1 vitamin drops brand recommendedis the #1 vitamin drops brand

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, by pediatricians is not intended to diagnose, treat, cure or prevent any disease. treat, is not intended to diagnose, Enfamil a developing immune system Helps support avors cial colors or fl No artifi Iron Vitamin B Niacin Ribofl Thiamin Nutrient A Vitamin Per 1 mL % DV Infants under age 4 years % DV Children NUTRIENTS Vitamin D Vitamin E Vitamin C Kosher Refrigeration is not required † This statement has not been evaluated by the Food and Drug Administration. This product Administration. This statement and Drug has not been evaluated by the Food † • • • • • PRECAUTIONS: As with all vitamin products, parents should be cautioned Accidental Overdosage Or Intake against excessive dosage. In case of accidental overdose, the physician, poison control center While taking liquid multivitamin supplements with iron, a slight darkening of or hospital emergency should be notifi ed immediately. Patients with the teeth may occur. Brushing will minimize this temporary condition. a known exposure of more than 40 mg/kg of elemental iron, or with severe, persistent symptoms related to iron ingestion, should be referred to a healthcare facility for medical evaluation and References observation. The vitamin ingredients would not be expected to cause 1. Wagner CL, Greer FR, et al. Prevention of rickets and vitamin D defi ciency in infants, children, and ill effects from a one-time overdose. adolescents. Pediatrics. 2008;122:1142-1152. 2. Data on fi le, Mead Johnson Nutrition, September 2009. WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

210 Enfamil

Notes

® Poly-Vi-Sol

® with Iron Liquid Multivitamin Supplement

211 ® Enfamil Enfamil Tri-Vi-Sol does not contain ingredients derived from the most ® common food allergens: milk, eggs, peanuts, tree nuts, fi sh, shellfi sh, Tri-Vi-Sol soy or wheat. Liquid Vitamins A, C & D Supplement Osmolality When added to 2 fl oz of infant formula or breast milk, 1 mL of Enfamil Tri-Vi-Sol Liquid Vitamins A, C & D Supplement increases the osmolality by Description/Indication +115 mOsm/kg water2,*. If the resulting osmolality is higher than desired Enfamil Tri-Vi-Sol Liquid Vitamins A, C & D Supplement is for exclusively or for a particular baby, an option is to add 0.5 mL of the supplement to the partially breastfed infants and toddlers. feeding twice per day.

* A previous formulation was evaluated.

Rationale And Special Characteristics Enfamil Tri-Vi-Sol has 3 frequently recommended vitamins in amounts that Product Features are suitable for daily administration to infants in a convenient daily serving. • 100% of daily vitamin D as recommended by the AAP, an essential Vitamins A, C and D are important for supporting growth and immune vitamin that helps your baby’s body absorb calcium for strong bones system development. and teeth† • Vitamin A helps keep skin, vision and mucous membranes healthy† The American Academy of Pediatrics (AAP) recommends 400 IU of • Vitamin C promotes healthy connective tissue development† supplemental vitamin D per day beginning in the fi rst days of life for all breastfed and partially breastfed infants who do not receive at least • No artifi cial colors or fl avors 1 L of infant formula per day1. • Refrigeration is not required • Kosher Most breastfed babies require a vitamin D supplement such as Enfamil® ® D-Vi-Sol Liquid Vitamin D Supplement. However, there may be certain † This statement has not been evaluated by the Food and Drug Administration. This product is maternal conditions that warrant additional vitamins such as vitamin A. not intended to diagnose, treat, cure or prevent any disease.

212 Enfamil® Tri-Vi-Sol® Liquid Vitamins A, C & D Supplement 213 . 2008;122:1142-1152. . Pediatrics children, and adolescents. and adolescents. children, Wagner CL, Greer FR, et al. Prevention of rickets and vitamin D defi ciency in infants, in infants, ciency and vitamin D defi Prevention of rickets et al. Greer FR, CL, Wagner September 2009. Mead Johnson Nutrition, le, Data on fi 1. 2. References 50 100 333 250 50 83 10 (400 IU) 100 67 Liquid Vitamins A, C & D Supplement is available C & D Supplement A, Vitamins Liquid Glycerin, water, polysorbate 80 (emulsifi er), er), polysorbate 80 (emulsifi water, Glycerin, ® As with all vitamin products, parents should be As with all vitamin products, As with medicines, keep out of the reach of children. keep out of the reach As with medicines,

mcg mg mcg RAE

, , , Tri-Vi-Sol ®

Ingredients:

Vitamin D Nutrient A Vitamin Per 1 mL % DV Infants under age 4 years % DV Children NUTRIENTS Vitamin C cautioned against excessive dosage. cautioned against excessive dosage. Other WARNING: Composition avor. natural ﬂ sodium hydroxide, PRECAUTIONS:

Enfamil Product Form Drops: 1 mL. Drops: Usual Daily Serving page 300. as drops in 50 mL bottles. For ordering information, please refer to ordering information, For as drops in 50 mL bottles. ® Enfamil Side Effects Fer-In-Sol® Temporary discoloration of the teeth due to liquid iron supplements can be minimized by thorough brushing. While taking iron, stools may appear darker Liquid Iron in color. This is normal and no cause for concern. Supplement

Product Features Description/Indication • 1 mL = 15 mg of elemental iron Enfamil Fer-In-Sol Liquid Iron Supplement is for the supplemental iron needs of infants and children. Infants who may especially require supplemental iron • Has the recommended daily amount of iron for infants and toddlers include infants of anemic mothers1,2, low-birth-weight infants1,3,4 and infants • Kosher (Note: the alcohol in Enfamil Fer-In-Sol is not approved for Passover) of mothers with poorly managed diabetes4.

Product Form Osmolality Enfamil Fer-In-Sol Liquid Iron Supplement is available as drops in 50 mL bottles. When added to 2 ﬂ oz of infant formula or breast milk, 1 mL of For ordering information, please refer to page 298. Enfamil Fer-In-Sol Liquid Iron Supplement increases the osmolality by +55 mOsm/kg water5,*. If the resulting osmolality is higher than desired Usual Daily Serving for a particular baby, an option is to add 0.5 mL of the supplement to Drops: 1 mL or as prescribed. the feeding twice per day.

* A previous formulation was evaluated. Composition Other Ingredients: Water, sugar, sorbitol, citric acid (antioxidant for iron), alcohol (0.2% v/v), sodium bisulfi te (preservative), natural fl avors, sulfi tes.

214 Enfamil® Fer-In-Sol® Liquid Iron Supplement 215 Pediatric ). 2005;43:553-570. ). Clin Toxicol (Phila Clin Toxicol Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Boron, Arsenic, Vitamin K, A, Vitamin Dietary Reference Intakes for . 1999;104:119-123. . Pediatrics . 2005;115:496-506. . . 7th ed. Elk Grove Village, Ill: AAP;2014. Ill: Village, Elk Grove 7th ed. . Washington, DC: National Academy Press; 2001. National DC: Washington, Pediatrics and Vanadium, Silicon, Nickel, Molybdenum, Manganese, Iron, Iodine, Copper, Chromium, Zinc. Nutrition guideline for out-of-hospital management. formulas. formulas. and the use of human milk. Breastfeeding et al. Lawrence RA, Morton J, Gartner LM, Institute of Medicine. September 2009. Mead Johnson Nutrition, le, Data on fi an evidence-based consensus Iron ingestion: et al. Booze LL, AR, Erdman AS, Manoguerra American Academy of Pediatrics, Committee on Nutrition. Iron fortifi cation of infant Iron fortifi Committee on Nutrition. Academy of Pediatrics, American American Academy of Pediatrics, Committee on Nutrition. Kleinman RE, ed. ed. Kleinman RE, Committee on Nutrition. Academy of Pediatrics, American References 1. 2. 5. 6. 3. 4. 15 136 214 Patients with Patients As with all vitamin products, parents should be parents should As with all vitamin products,

. 6 mg

, NutrientIron Per 1 mL % DV Infants under age 4 years % DV Children NUTRIENTS the product. Any color within this range is normal and does not affect the potency of Any color within this range is normal and does not affect the potency Enfamil Fer-In-Sol varies in color from colorless to bluish-green to amber. to amber. varies in color from colorless to bluish-green Enfamil Fer-In-Sol PRECAUTIONS: cautioned against excessive dosage. cautioned against excessive dosage. or hospital emergency should be notifi ed immediately. ed immediately. be notifi should or hospital emergency observation In case of accidental overdose, the physician, poison control center poison control the physician, In case of accidental overdose, and for medical evaluation facility be referred to a healthcare with severe, persistent symptoms related to iron ingestion, should persistent symptoms related to iron ingestion, with severe, Accidental Overdosage Or Intake Accidental Overdosage or iron, of more than 40 mg ⁄ kg of elemental a known exposure doctor or poison control center immediately. out of the reach of children. In case of accidental overdose, call a In case of accidental overdose, out of the reach of children. leading cause of fatal poisoning in children under 6. Keep this product Keep this poisoning in children under 6. leading cause of fatal WARNING: Accidental overdose of iron-containing products is aWARNING: Enfamom™ Product Features Prenatal • DHA: ° 200 mg DHA per softgel Vitamin & Mineral ° Expert-recommended DHA to help support brain and Supplement eye development* • Folate: ° Has 99% recommended daily value for folate Description/Indication ° Helps support brain development and central nervous Enfamom Prenatal Vitamin & Mineral Supplement is specially formulated system development* to support women’s health throughout pregnancy while supporting a • Calcium: * baby’s development needs . It is designed to be used before, during and ° 250 mg calcium to support bone health* after pregnancy. The patient should consult her doctor before taking ° 25% higher calcium than the leading brand† any supplement. Docosahexaenoic acid (DHA) is an omega-3 fatty acid Vitamin D to help promote calcium absorption* that is an important structural element of the brain and retina*. DHA is a ° component important for baby’s brain and eye development*. • No high-fructose corn syrup • No artifi cial fl avors • No artifi cial sweeteners • Sugar-free

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

† 250 mg vs. 200 mg in One A Day®. Enfamom has not been shown to be superior in supporting bone health compared to One A Day. One A Day is a registered trademark of an entity unrelated to Mead Johnson & Company, LLC.

216 Enfamom™ Prenatal Vitamin & Mineral Supplement 217 ‡ 2 154 8 286 2.5 125 2 125 1.7 121 28501535 104 13 115 ‡ 10 143 20 111 601020.1 50 67 106 150200 52 ‡ 300250 857 19 595 99 mg mg

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(Eicosapentaenoic Acid), , , ‡ Daily value not established. Daily value not established. ‡ Omega-3 Fatty Acids Omega-3 Fatty Iodine Magnesium Zinc Copper DHA EPA Biotin Pantothenic Acid Calcium Iron Folate Vitamin B Niacin Vitamin B Riboﬂ Vitamin D Vitamin E Thiamin Nutrient A Vitamin Vitamin C Amount per ServingWomen and Lactating for Pregnant % DV NUTRIENTS WARNING: Accidental overdose of iron-containing products is a Product Form leading cause of fatal poisoning in children under 6. KEEP THIS Enfamom™ Prenatal Vitamin & Mineral Supplement is available in bottles PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, with 30 softgels. For ordering information, please refer to page 300. call a doctor or poison control center immediately.

Do not exceed suggested serving. If pregnant, considering pregnancy, breastfeeding, are taking medication, or have a medical condition, please Composition seek the advice of a healthcare professional before using. Folate intake should not exceed 1,000 mcg. As with any product that has iron or the Ingredients: As noted in supplement facts. fat-soluble vitamins D and E, adhere carefully to the amount recommended Other Ingredients: Bovine gelatin, glycerin, medium chain triglycerides, by your healthcare professional. Do not use if safety seal under cap is torn yellow beeswax, puriﬁ ed water, soy lecithin, annatto color. or missing. Due to the sources of color, some dark spots may appear on softgel over time. This does not impact product quality.

Potential Allergens Enfamom Prenatal Vitamin & Mineral Supplement contains ﬁ sh (anchovy, mackerel, sardine, smelt and tuna), soy and sulﬁ tes.

218 Enfamom

Notes

™ Prenatal Vitamin & Mineral Supplement

219 ® Product Features Enfamil Infant • Has LGG & BB-12 probiotics, two of the most clinically studied probiotics Probiotics shown to support the immune system*,† • Designed to support the digestive system where nutrient absorption Dietary Supplement occurs* • No artiﬁ cial sweeteners, ﬂ avors or silicone dioxide

® ® Description/Indication LGG and BB-12 are registered trademarks of Chr. Hansen A/S. Enfamil Infant Probiotics is a dietary supplement for infants 0–12 months * These statements have not been evaluated by the Food and Drug Administration. This product is of age. It has two of the most clinically studied probiotic strains, LGG® and not intended to diagnose, treat, cure, or prevent any disease. ® ,† BB-12 to support the immune system.* † Clinical studies in LGG® & BB-12® probiotics individually, given in probiotic supplement or formula and/or toddler years.

220 Enfamil® Infant Probiotics Dietary Supplement 221 High oleic sunﬂ ower oil, vitamin E (antioxidant). ower oil, High oleic sunﬂ As noted in Supplement Facts. As noted in Ingredients:

Talk to your baby’s doctor about Enfamil Infant Probiotics Dietary doctor about Enfamil Infant to your baby’s Talk premature doctor before using in Consult with your baby’s Supplement. or if consuming other products thator immunocompromised babies such as supplements or formulas. have probiotics, Ingredients: Other Composition 12 (2.5 billion CFU)12 (2.5 ‡ mg

), Lactobacillus rhamnosus, Bifi dobacterium Bifi rhamnosus, Lactobacillus ( Infant Probiotics is available as drops in 0.3 ﬂ oz bottles. oz bottles. Infant Probiotics is available as drops in 0.3 ﬂ ®

animalis subsp. lactis animalis subsp. Nutrient Blend Probiotic Per 6 dropsAge %DV Infants through 12 Months of NUTRIENTS ‡ Daily value not established. Daily value not established. ‡ 6 drops daily. Usual Daily Serving For ordering information, please refer to page please refer 297. information, For ordering

Enfamil Product Form ® Enfamil Product Features Breastfed Infant • Has LGG & BB-12 probiotics, two of the most clinically studied probiotics shown to support the immune system*,† Probiotics • 100% of daily vitamin D as recommended by the AAP, an essential vitamin that helps your baby’s body absorb calcium for strong bones & Vitamin D and teeth* • Designed to support the digestive system where nutrient absorption occurs* Description/Indication • No artiﬁ cial sweeteners, ﬂ avors or silicone dioxide Enfamil Breastfed Infant Probiotics & Vitamin D is a dietary supplement for fully or partially breastfed infants 0–12 months of age. It has two LGG® and BB-12® are registered trademarks of Chr. Hansen A/S. of the most clinically studied probiotic strains, LGG® and BB-12®, and vitamin D as recommended by experts for all breastfed infants. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

† Clinical studies in LGG® & BB-12® probiotics individually, given in probiotic supplement or formula and/or toddler years.

222 Enfamil® Breastfed Infant Probiotics & Vitamin D 223 High oleic sunﬂ ower oil, vitamin E (antioxidant). ower oil, High oleic sunﬂ As noted in Supplement Facts.

Ingredients:

Talk to your baby’s doctor about Enfamil Breastfed Infant Probiotics and doctor about Enfamil Breastfed to your baby’s Talk doctor before Consult with your baby’s Vitamin D Dietary Supplement. using in premature or immunocompromised babies or if consuming such as supplements or formulas. other products that have probiotics, Ingredients: Other Composition 10 (400 IU)10 (400 100 12 (2.5 billion CFU) ‡ mcg

), Lactobacillus rhamnosus, Bifi dobacterium Bifi Lactobacillus rhamnosus, ( (Cholecalciferol), Breastfed Infant Probiotics & Vitamin D is available as drops in & Breastfed Infant Probiotics ®

animalis subsp. lactis animalis subsp. Probiotic Blend Probiotic Blend Nutrient D Vitamin Per 6 dropsAge %DV Infants through 12 Months of NUTRIENTS ‡ Daily value not established. Daily value not established. ‡ 6 drops daily. Usual Daily Serving 0.3 ﬂ oz bottles. For ordering information, please refer to page 297. refer to page please 297. information, ordering For oz bottles. 0.3 ﬂ

Enfamil Product Form Notes

224 Metabolic Formulas • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 BCAD 1 • Halal

Product Form BCAD 1 is available in powder. For ordering information, please refer to Description/Indication page 296. BCAD 1 is an iron-fortifi ed infant formula and medical food powder that is free of the branched chain amino acids isoleucine, leucine and valine for the dietary management of infants and toddlers with documented maple Composition syrup urine disease (MSUD). The product provides all other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty Ingredients: Corn syrup solids, vegetable oil (palm olein, coconut oil, acids, vitamins and minerals. Use under direct and continuing supervision soy oil, high oleic sunfl ower oil), amino acids (L-glutamine, L-lysine of a doctor. hydrochloride, potassium aspartate, L-proline, L-alanine, L-arginine, L-phenylalanine, L-tyrosine, L-serine, L-threonine, glycine, L-histidine, L-methionine, L-tryptophan, L-cystine), modifi ed corn starch, sugar, calcium * Product Features phosphate and less than 1%: Mortierella alpina oil , Crypthecodinium cohnii oil†, ethyl vanillin, sodium citrate, potassium citrate, magnesium oxide, • DHA and ARA ferrous sulfate, potassium chloride, zinc sulfate, cupric sulfate, manganese • Isoleucine-, leucine-, valine-free sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic • Vitamin and mineral levels meet the U.S. Infant Formula Act acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin requirements per 100 Calories hydrochloride, ribofl avin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E • Increased levels of B vitamins, compared to routine infant formulas, acetate, vitamin A palmitate, vitamin B12, taurine, L-carnitine. for cofactor production * A source of arachidonic acid (ARA). • Vanilla scent † A source of docosahexaenoic acid (DHA). • Mixes easily and stays in suspension well

226 BCAD 1 NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 500 Biotin, mcg 38 Protein equivalent, g‡ 16.2 Vitamin C (Ascorbic acid), mg 60 Fat, g 26 Choline, mg 124 Linoleic acid, mg 4000 Inositol, mg 86 Carbohydrate, g 51 Minerals Vitamins/Other Nutrients Calcium, mg 660 Vitamin A, IU 1520 Phosphorus, mg 440 Vitamin D, IU 380 Magnesium, mg 66 Vitamin E, IU 10 Iron, mg 9.6 Vitamin K, mcg 40 Zinc, mg 8.6

Thiamin (Vitamin B1), mcg 1000 Manganese, mcg 380

Riboﬂ avin (Vitamin B2), mcg 1000 Copper, mcg 860

Vitamin B6, mcg 1000 Iodine, mcg 76

Vitamin B12, mcg 2 Selenium, mcg 14.1 Niacin, mcg 10000 Sodium, mg 240 Folic acid (Folacin), mcg 100 Potassium, mg 600 Pantothenic acid, mcg 3800 Chloride, mg 500

NUTRIENT FACTS Protein Equivalent (% Calories)‡ 13 Potential Renal Solute Load (mOsm/100 g powder)3 147 Fat (% Calories) 47 Osmolality (mOsm/kg water)§ 330 Carbohydrate (% Calories) 40 Osmolarity (mOsm/L)§ 300

‡ WARNING: This protein is incomplete since it does not contain the essential amino acids isoleucine, leucine and valine. § Determined at 20 Cal/ﬂ oz dilution.

227 WARNING: This product is nutritionally incomplete. Care must be taken References to provide enough isoleucine, leucine and valine to support growth using 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboﬂ avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. other foods with these amino acids as required. Medical professionals must Washington, DC: National Academies Press; 1998:390-422. carefully and constantly supervise use of BCAD 1 with other foods and 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: liquids and adjust the diet based on frequent blood tests. 615-623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. CAUTION: Mead Johnson Nutrition BCAD 1 is to be used only in the dietary 1999;134:11-14. management of infants and young children with documented maple syrup urine disease while under direct and continuing medical supervision. WARNING: Not for parenteral (I.V.) use.

228 BCAD 1

Notes

229 PRODUCT FORM BCAD 2 is available in powder. For ordering information, please refer to BCAD 2 page 296.

Composition Ingredients: Corn syrup solids, amino acids (L-glutamine, L-lysine Description/Indication hydrochloride, potassium aspartate, L-proline, L-alanine, L-arginine, L-phenylalanine, L-tyrosine, L-threonine, L-serine, glycine, L-histidine, BCAD 2 is an iron-fortifi ed medical food powder that is free of the branched L-methionine, L-tryptophan, L-cystine), sugar, soy oil, modifi ed corn chain amino acids isoleucine, leucine and valine for the dietary management starch, calcium phosphate and less than 1%: sodium citrate, magnesium of children and adults with documented maple syrup urine disease (MSUD). phosphate, potassium chloride, sodium phosphate, potassium citrate, The product provides all other essential amino acids as well as nonessential choline chloride, ascorbic acid, taurine, inositol, ferrous sulfate, L-carnitine, amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. zinc sulfate, niacinamide, vitamin E acetate, vitamin A palmitate, calcium Use under direct and continuing supervision of a doctor. pantothenate, cupric sulfate, manganese sulfate, vitamin B12, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, Product Features chromic chloride, sodium molybdate, sodium iodide, biotin, sodium selenite, vitamin K1, ethyl vanillin. • Isoleucine-, leucine-, valine-free • 24 g protein equivalent ⁄100 g powder WARNING: This product is nutritionally incomplete. Continuing medical • Higher level of protein equivalent than found in BCAD 1 supervision and frequent blood tests are required. BCAD 2 must be • Suitable for someone with lactose intolerance supplemented using other food sources of protein and fl uid to provide enough isoleucine, leucine and valine to support dietary requirements of • Vanilla scent children and adults. • Can be easily modifi ed with preferred fl avor enhancers CAUTION: Mead Johnson Nutrition BCAD 2 is to be used only in the dietary • Mixes easily and stays in suspension well management of children and adults with documented maple syrup urine • Vitamin and mineral levels appropriate for children and adults disease or other inborn errors of branched chain amino acid metabolism • Halal while under direct and continuing medical supervision. WARNING: Not for parenteral (I.V.) use. 230 BCAD 2 231 57 98 57 63 37 37 12.2 12.2 28 Powder 730 730 610 163 1020 1220 1220 1300 57 Suitable for someone with lactose intolerance mg

(% Calories) mg mcg

, , mg mcg

, mg , mcg

mcg , , (Ascorbic acid), (Ascorbic

mg , mg

mg mg mcg ,

, , mcg , ,

, mg mg

, , Carbohydrate Carbohydrate Lactose-free Phosphorous Minerals Calcium Inositol Chloride Potassium Choline Sodium Copper Iodine Molybdenum Chromium Manganese Zinc Iron Magnesium Vitamin C Vitamin Selenium 24 19 8. 5 2.8 57 57 24 47 11.4 Powder 410 350 410 product label for current information. see Please to change. and ingredients are subject values Product nutrient 4200 5700 1420 1140 1730 1140 26000 Per 100 gramsPer 100 Per 100 grams * mcg

), mcg

2 g* mcg (% Calories) ),

, 1 mcg

, g

, , mg mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B mcg mcg

, , avin avin g

(% Calories) , * WARNING: This protein is incomplete since it does not contain the essential amino acids isoleucine, leucine and valine. leucine protein is incomplete since it does not contain the essential amino acids isoleucine, This * WARNING: Linoleic acid Nutrients Vitamins/Other Carbohydrate Biotin Fat Pantothenic acid Protein equivalent Riboﬂ Vitamin B Folic acid Niacin Vitamin K Thiamin Vitamin D Vitamin E Protein Equivalent Protein Equivalent NUTRIENT FACTS Vitamin A Calories Vitamin B Fat NUTRIENTS • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 GA • Halal

Product Form GA is available in powder. For ordering information, please refer to Description/Indication page 300. GA is an iron-fortifi ed infant formula and medical food powder that is free of the essential amino acids lysine and tryptophan for infants, children and adults with documented glutaric acidemia type 1. The product provides Composition the other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. Use under Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut direct and continuing supervision of a doctor. oil, soy oil, high oleic sunfl ower oil), amino acids (L-alanine, L-leucine, potassium aspartate, L-proline, L-valine, L-isoleucine, L-arginine, glycine, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-methionine, L-cystine), modifi ed corn starch, sugar, calcium phosphate Product Features and less than 1%: Mortierella alpina oil*, Crypthecodinium cohnii oil†, ethyl vanillin, sodium citrate, potassium citrate, potassium chloride, magnesium • DHA and ARA oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, • Lysine- and tryptophan-free sodium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, • Vitamin and mineral levels meet the U.S. Infant Formula Act niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin requirements per 100 Calories hydrochloride, ribofl avin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E • Increased levels of B vitamins, compared to routine infant formulas, acetate, vitamin A palmitate, vitamin B12, taurine, L-carnitine. for cofactor production • Vanilla scent * A source of arachidonic acid (ARA). † A source of docosahexaenoic acid (DHA). • Mixes easily and stays in suspension well

232 GA 233 8.6 9.6 66 86 14.1 76 60 38 Powder 440 330 660 800 124 240 860 380 370 330 Suitable for someone with lactose intolerance § mg

§ mg

, mg mcg

, (mOsm/L) mg , (mOsm/kg water)

mcg , (Ascorbic acid),

mg , mg

mg mg mcg ,

, , mcg , , mcg

, , mg mg

, ,

Lactose-free Osmolarity Osmolality Zinc Iron Magnesium Phosphorous Chloride Minerals Calcium Inositol Potassium Choline Sodium Copper Selenium Iodine Vitamin C Manganese Biotin 41 47 12 140 2 40 10 52 26 15.1 380 100 500 Powder product label for current information. see Please to change. and ingredients are subject values Product nutrient 1520 3800 4000 1000 1000 1000 10000 Per 100 gramsPer 100 Per 100 grams 3 ‡ (mOsm/100 g powder) mcg

), mcg ‡

2 g mcg (% Calories) ),

, 1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B mcg

, avin avin g

(% Calories) , Thiamin Vitamin K Vitamin E Vitamin D Vitamin A Carbohydrate Nutrients Vitamins/Other Pantothenic acid Linoleic acid Folic acid Vitamin B Niacin Vitamin B Fat Ribofl Protein equivalent Protein Equivalent Protein Equivalent Fat Carbohydrate Potential Renal Solute Load NUTRIENT FACTS Calories NUTRIENTS ‡ WARNING: This protein is incomplete since it does not contain the essential amino acids lysine and tryptophan.This protein is incomplete since it does not contain the essential amino acids WARNING: ‡ oz dilution. Determined at 20 Cal/fl § WARNING: This product is nutritionally incomplete. Care must be taken to References provide enough lysine and tryptophan to support growth using other foods 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Ribofl avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. with these amino acids as required. Medical professionals must carefully Washington, DC: National Academies Press;1998:390-422. and constantly supervise use of GA with other foods and liquids and adjust 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: the diet based on frequent blood tests. 615-623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. CAUTION: Mead Johnson Nutrition GA is to be used only in the dietary 1999;134:11-14. management of infants, children, and adults with documented glutaric acidemia type 1 while under direct and continuing medical supervision. WARNING: Not for parenteral (I.V.) use.

234 GA

Notes

235 • Mixes easily and stays in suspension well • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 HCY 1 • Halal

Product Form Description/Indication HCY 1 is available in powder. For ordering information, please refer to page 300. HCY 1 is an iron-fortifi ed infant formula and medical food powder that is free of the essential amino acid methionine for infants and toddlers with documented homocystinuria. The product provides all other essential amino acids as well as nonessential amino acids, carbohydrate, fat, essential fatty Composition acids, vitamins and minerals. Use under direct and continuing supervision Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, of a doctor. soy oil, high oleic sunfl ower oil), amino acids (L-glutamine, L-leucine, potassium aspartate, L-lysine hydrochloride, L-proline, L-valine, L-isoleucine, L-alanine, L-arginine, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-cystine, glycine, L-histidine, L-tryptophan), modifi ed corn Product Features starch, sugar, calcium phosphate and less than 1%: Mortierella alpina • DHA and ARA oil*, Crypthecodinium cohnii oil†, ethyl vanillin, sodium citrate, potassium • Methionine-free citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite), choline • Added cystine chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin • Vitamin and mineral levels meet the U.S. Infant Formula Act B6 hydrochloride, thiamin hydrochloride, ribofl avin, vitamin D3, folic acid, requirements per 100 Calories biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, • Increased levels of B vitamins, compared to routine infant formulas, taurine, L-carnitine. for cofactor production • Vanilla scent * A source of arachidonic acid (ARA). † A source of docosahexaenoic acid (DHA).

236 HCY 1 237 8.6 9.6 86 66 76 60 14.1 38 660 440 380 860 240 430 124 560 Powder 350 320 Suitable for someone with lactose intolerance § mg

§ mg mg mcg

, , mg , (mOsm/L) (mOsm/kg water)

mcg , (Ascorbic acid),

mg , mg

mg mg mcg ,

, , mcg , , mcg

, , mg mg

, , Phosphorus Minerals Calcium Iron Zinc Magnesium Inositol Manganese Copper Chloride Potassium Sodium Choline Iodine Selenium Vitamin C Lactose-free Osmolarity Biotin Osmolality 2 51 10 40 26 16.2 40 47 13 Powder 380 100 500 144 1520 4000 1000 1000 3800 1000 10000 Per 100 gramsPer 100 Per 100 grams current information.label for Please see product are subject to change. nutrient values and ingredients Product 3 ‡ (mOsm/100 g powder) mcg

), mcg ‡

2 g mcg (% Calories) ),

, 1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B mcg

, avin avin g

(% Calories) , Thiamin Carbohydrate Nutrients Vitamins/Other Vitamin A Vitamin D Vitamin E Vitamin K Ribofl Vitamin B Vitamin B Folic acid Linoleic acid Fat Niacin Protein equivalent Fat Carbohydrate Potential Renal Solute Load NUTRIENT FACTS Protein Equivalent Calories NUTRIENTS Pantothenic acid ‡ WARNING: Protein is incomplete since it does not contain the essential amino acid methionine. WARNING: ‡ oz dilution. Determined at 20 Cal/fl § CAUTION: Mead Johnson Nutrition HCY 1 is to be used only in the References dietary management of infants and young children with documented 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Ribofl avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. homocystinuria while under direct and continuing medical supervision. Washington, DC: National Academies Press;1998:390-422. WARNING: This product is nutritionally incomplete. Care must be taken to 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: provide enough methionine to support growth using other foods with this 615-623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. amino acid as required. Medical professionals must carefully and constantly 1999;134:11-14. supervise use of HCY 1 with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

238 HCY 1

Notes

239 Product Form HCY 2 is available in powder. For ordering information, please refer to HCY 2 page 300.

Composition Description/Indication Ingredients: Corn syrup solids, amino acids (L-glutamine, L-leucine, L-lysine hydrochloride, potassium aspartate, L-proline, L-valine, HCY 2 is a medical food powder that is free of the essential amino acid L-isoleucine, L-alanine, L-arginine, L-threonine, L-phenylalanine, L-tyrosine, methionine for children and adults with documented homocystinuria. The L-serine, L-cystine, glycine, L-histidine, L-tryptophan), sugar, soy oil, product provides all other essential amino acids as well as nonessential modifi ed corn starch, calcium phosphate, sodium citrate, magnesium amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. phosphate, potassium chloride and less than 1%: sodium phosphate, Use under direct and continuing supervision of a doctor. potassium citrate, choline chloride, ascorbic acid, taurine, inositol, ferrous sulfate, L-carnitine, zinc sulfate, niacinamide, vitamin E acetate, vitamin A palmitate, calcium pantothenate, cupric sulfate, manganese sulfate, vitamin Product Features B12, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, • Methionine-free vitamin D3, chromic chloride, sodium molybdate, sodium selenite, sodium • Cystine level is similar to the sum of cystine and methionine iodide, biotin, vitamin K1, ethyl vanillin. found in cow’s milk • 22 g protein equivalent/100 g powder CAUTION: Mead Johnson Nutrition HCY 2 is to be used only in the dietary • Suitable for someone with lactose intolerance management of children and adults with documented homocystinuria • Vanilla scent while under direct and continuing medical supervision. • Can be easily modifi ed with preferred fl avor enhancers WARNING: This product is nutritionally incomplete. Continuing medical supervision and frequent blood tests are required. HCY 2 must be • Mixes easily and stays in suspension well supplemented using other food sources of protein and fl uid to provide • Vitamin and mineral levels appropriate for children and adults enough methionine to support dietary requirements of children and adults. • Halal WARNING: Not for parenteral (I.V.) use.

240 HCY 2 241 57 98 63 45 45 13.8 13.8 57 33 730 730 590 960 163 Powder 1430 1100 1500 59 Suitable for someone with lactose intolerance mg

mcg (% Calories)

mg , mg mcg

, , mg , mcg

mcg , , (Ascorbic acid), (Ascorbic

mg , mg

mg mg mcg ,

, , mcg , ,

, mg mg

, , Phosphorus Calcium Minerals Inositol Potassium Choline Copper Iodine Chloride Sodium Molybdenum Chromium Manganese Zinc Iron Lactose-free Vitamin C Vitamin Magnesium Selenium Carbohydrate 8.5 2.9 61 22 57 47 12.2 57 410 350 410 4200 5700 1430 1140 1730 1140 Powder 19 22 26000 Per 100 gramsPer 100 Per 100 grams current information.label for Please see product are subject to change. nutrient values and ingredients Product * mg

mcg

), mcg *

2 g mcg (% Calories) ),

, 1 mcg

, g

mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin), (Ascorbic acid),

, 6 12 , , , (Vitamin B mcg mcg

, ,

avin avin g

(% Calories) , * amino acid methionine. Protein is incomplete since it does not contain the essential WARNING: Vitamins/Other Nutrients Vitamins/Other Carbohydrate Linoleic acid Fat Riboﬂ Vitamin B Pantothenic acid Biotin Vitamin C Folic acid Niacin Vitamin K Vitamin E Thiamin Protein equivalent Vitamin D Vitamin B Fat Protein Equivalent Protein Equivalent NUTRIENT FACTS Vitamin A Calories NUTRIENTS • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 • Halal LMD

Product Form LMD is available in powder. For ordering information, please refer to Description/Indication page 300. LMD is an iron-fortifi ed infant formula and medical food powder that is free of the essential amino acid leucine for infants, children and adults with documented leucine metabolism disorders, including isovaleric Composition acidemia. The product provides the other essential amino acids as well as Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins oil, soy oil, high oleic sunfl ower oil), amino acids (L-alanine, L-lysine and minerals. Use under direct and continuing supervision of a doctor. hydrochloride, potassium aspartate, L-proline, L-arginine, glycine, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-valine, L-isoleucine, L-histidine, L-methionine, L-tryptophan, L-cystine), modifi ed corn starch, Product Features sugar, calcium phosphate and less than 1%: Mortierella alpina oil*, Crypthecodinium cohnii oil†, ethyl vanillin, sodium citrate, potassium • DHA and ARA citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, • Leucine-free cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline • Vitamin and mineral levels meet the U.S. Infant Formula Act chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin requirements per 100 Calories B6 hydrochloride, thiamin hydrochloride, ribofl avin, vitamin D3, folic acid, • Increased levels of B vitamins, compared to routine infant formulas, biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, for cofactor production taurine, L-carnitine. • Vanilla scent * A source of arachidonic acid (ARA). • Mixes easily and stays in suspension well † A source of docosahexaenoic acid (DHA).

242 LMD NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 500 Biotin, mcg 38 Protein equivalent, g‡ 16.2 Vitamin C (Ascorbic acid), mg 60 Fat, g 26 Choline, mg 124 Linoleic acid, mg 4000 Inositol, mg 86 Carbohydrate, g 51 Minerals Vitamins/Other Nutrients Calcium, mg 660 Vitamin A, IU 1520 Phosphorous, mg 440 Vitamin D, IU 380 Magnesium, mg 66 Vitamin E, IU 10 Iron, mg 9.6 Vitamin K, mcg 40 Zinc, mg 8.6

Thiamin (Vitamin B1), mcg 1000 Manganese, mcg 380

Riboﬂ avin (Vitamin B2), mcg 1000 Copper, mcg 860

Vitamin B6, mcg 1000 Iodine, mcg 76

Vitamin B12, mcg 2 Selenium, mcg 14.1 Niacin, mcg 10000 Sodium, mg 240 Folic acid (Folacin), mcg 100 Potassium, mg 580 Pantothenic acid, mcg 3800 Chloride, mg 480

NUTRIENT FACTS Protein Equivalent (% Calories)‡ 13 Osmolality (mOsm/kg water) 370 Fat (% Calories) 47 Osmolarity (mOsm/L) 330 Carbohydrate (% Calories) 40 Lactose-free Suitable for someone with lactose intolerance Potential Renal Solute Load (mOsm/100 g powder)3 145

‡ WARNING: Protein is incomplete since it does not contain the essential amino acid leucine.

243 CAUTION: Mead Johnson Nutrition LMD is to be used only in the dietary References management of infants, children and adults with documented disorders of 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboﬂ avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. leucine metabolism, including isovaleric acidemia, while under direct and Washington, DC: National Academies Press;1998:390-422. continuing medical supervision. 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009:67: WARNING: This product is nutritionally incomplete. Care must be taken 615–623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. to provide enough leucine to support growth using other foods with this 1999;134:11–14. amino acid as required. Medical professionals must carefully and constantly supervise use of LMD with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

244 LMD

Notes

245 • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 • Halal OA 1

Product Form OA 1 is available in powder. For ordering information, please refer to page 301. Description/Indication OA 1 is an iron-fortifi ed infant formula and medical food powder that is free of the essential amino acids isoleucine, methionine, threonine and valine for Composition infants and toddlers with documented propionic or methylmalonic acidemia Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut (organic acidemias). The product provides the other essential amino acids oil, soy oil, high oleic sunfl ower oil), amino acids (L-alanine, L-leucine, as well as nonessential amino acids, carbohydrate, fat, essential fatty acids, L-lysine hydrochloride, potassium aspartate, L-proline, L-arginine, glycine, vitamins and minerals. Use under direct and continuing supervision of a doctor. L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-tryptophan, L-cystine), modifi ed corn starch, sugar, calcium phosphate and less than 1%: Mortierella alpina oil*, Crypthecodinium cohnii oil†, ethyl vanillin, sodium Product Features citrate, potassium citrate, magnesium oxide, ferrous sulfate, potassium • DHA and ARA chloride, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic acid, niacinamide, • Isoleucine-, methionine-, threonine- and valine-free calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, • Vitamin and mineral levels meet the U.S. Infant Formula Act ribofl avin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E acetate, requirements per 100 Calories vitamin A palmitate, vitamin B12, taurine, L-carnitine. • Increased levels of B vitamins, compared to routine infant formulas, for cofactor production * A source of arachidonic acid (ARA). • Vanilla scent † A source of docosahexaenoic acid (DHA). • Mixes easily and stays in suspension well

246 OA 1 OA NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 500 Biotin, mcg 38 Protein equivalent, g‡ 15.7 Vitamin C (Ascorbic acid), mg 60 Fat, g 26 Choline, mg 124 Linoleic acid, mg 4000 Inositol, mg 86 Carbohydrate, g 51 Minerals Vitamins/Other Nutrients Calcium, mg 660 Vitamin A, IU 1520 Phosphorus, mg 440 Vitamin D, IU 380 Magnesium, mg 66 Vitamin E, IU 10 Iron, mg 9.6 Vitamin K, mcg 40 Zinc, mg 8.6

Thiamin (Vitamin B1), mcg 1000 Manganese, mcg 380

Riboﬂ avin (Vitamin B2), mcg 1000 Copper, mcg 860

Vitamin B6, mcg 1000 Iodine, mcg 76

Vitamin B12, mcg 2 Selenium, mcg 14.1 Niacin, mcg 10000 Sodium, mg 240 Folic acid (Folacin), mcg 100 Potassium, mg 560 Pantothenic acid, mcg 3800 Chloride, mg 480

NUTRIENT FACTS Protein Equivalent (% Calories)‡ 12 Osmolality (mOsm/kg water)§ 370 Fat (% Calories) 47 Osmolarity (mOsm/L)§ 330 Carbohydrate (% Calories) 41 Lactose-free Suitable for someone with lactose intolerance Potential Renal Solute Load (mOsm/100 g powder)3 142

‡ WARNING: Protein is incomplete since it does not contain the essential amino acids isoleucine, methionine, threonine and valine. § Determined at 20 Cal/ﬂ oz dilution. 247 CAUTION: Mead Johnson Nutrition OA 1 is to be used only in the dietary References management of infants and young children with documented propionic 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboﬂ avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. and methylmalonic acidemias while under direct and continuing medical Washington, DC: National Academy Press;1998:390-422. supervision. 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: WARNING: This product is nutritionally incomplete. Care must be taken 615–623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. to provide enough isoleucine, methionine, threonine and valine to support 1999;134:11–14. growth using other foods with these amino acids as required. Medical professionals must carefully and constantly supervise use of OA 1 with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

248 OA 1 OA

Notes

249 Product Form OA 2 is available in powder. For ordering information, please refer to OA 2 page 301.

Composition Ingredients: Corn syrup solids, sugar, amino acids (L-alanine, L-leucine, Description/Indication L-lysine hydrochloride, potassium aspartate, L-proline, L-arginine, OA 2 is a medical food powder that is free of the essential amino acids glycine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-tryptophan, isoleucine, methionine, threonine and valine for children and adults with L-cystine), soy oil, modifi ed corn starch, calcium phosphate, sodium documented propionic or methylmalonic acidemia (organic acidemia). The citrate, magnesium phosphate, potassium chloride and less than 1%: product provides all other essential amino acids as well as nonessential sodium phosphate, potassium citrate, choline chloride, ascorbic acid, amino acids, carbohydrate, fat, essential fatty acids, vitamins and minerals. taurine, inositol, ferrous sulfate, L-carnitine, zinc sulfate, niacinamide, Use under direct and continuing supervision of a doctor. vitamin E acetate, vitamin A palmitate, calcium pantothenate, cupric sulfate, manganese sulfate, vitamin B12, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, chromic chloride, sodium Product Features molybdate, sodium iodide, sodium selenite, biotin, vitamin K1, ethyl vanillin. • Isoleucine-, methionine-, threonine- and valine-free • Provides protein, linoleic and linolenic acid, and vitamins and minerals not CAUTION: Mead Johnson Nutrition OA 2 is to be used only in the dietary available from low-protein foods while supplying fewer calories than OA 1 management of children and adults with documented propionic acidemia • The protein source is a mixture of L-amino acids optimized for blandness, and methylmalonic acidemia while under direct and continuing medical free of isoleucine, methionine, threonine and valine supervision. • 21 g protein equivalent/100 g powder WARNING: This product is nutritionally incomplete. Continuing medical • Fat comprises approximately 20% of total Calories (9 g/100 g powder) supervision and frequent blood tests are required. OA 2 must be • Vanilla scent supplemented using other food sources of protein and fl uid to provide • Can be easily modifi ed with preferred fl avor enhancers enough isoleucine, methionine, threonine and valine to support dietary • Mixes easily and stays in suspension well requirements of children and adults. • Halal WARNING: Not for parenteral (I.V.) use. 250 OA 2 OA NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 410 Vitamin C (Ascorbic acid), mg 49 Protein equivalent, g* 21 Choline, mg 102 Fat, g 9 Inositol, mg 49 Linoleic acid, mg 4400 Minerals Carbohydrate, g 59 Calcium, mg 760 Vitamins/Other Nutrients Phosphorous, mg 760 Vitamin A, IU 1430 Magnesium, mg 177 Vitamin D, IU 290 Iron, mg 12.3 Vitamin E, IU 10.3 Zinc, mg 12.3 Vitamin K, mcg 41 Manganese, mcg 1350

Thiamin (Vitamin B1), mcg 1200 Copper, mcg 1220

Riboﬂ avin (Vitamin B2), mcg 980 Iodine, mcg 66

Vitamin B6, mcg 980 Selenium, mcg 27

Vitamin B12, mcg 2.4 Chromium, mcg 37 Niacin, mcg 22000 Molybdenum, mcg 37 Folic acid (Folacin), mcg 350 Sodium, mg 610 Pantothenic acid, mcg 4800 Potassium, mg 1160 Biotin, mcg 49 Chloride, mg 1060

NUTRIENT FACTS Protein Equivalent (% Calories)* 21 Carbohydrate (% Calories) 59 Fat (% Calories) 20 Lactose-free Suitable for someone with lactose intolerance

* WARNING: Protein is incomplete since it does not contain the essential amino acids isoleucine, methionine, threonine and valine.

251 Product Form PFD Toddler PFD Toddler is available in powder. For ordering information, please refer to page 301.

Composition Description/Indication Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, PFD Toddler is a protein- and amino acid-free product* designed with soy oil, high oleic sunfl ower oil), modifi ed corn starch, sugar, calcium carbohydrates, vitamins and minerals as well as the essential fatty acids for phosphate and less than 1%: Mortierella alpina oil†, Crypthecodinium cohnii young children with various documented amino acid metabolic disorders. oil‡, ethyl vanillin, sodium citrate, potassium chloride, potassium citrate, This product is for persons requiring a protein-free diet. PFD Toddler can magnesium oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese be used as a dietary supplement supplying calories, vitamins and minerals, sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic or specifi c amounts of amino acids or protein can be added to make a acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin complete beverage. Use under direct and continuing supervision of a doctor. hydrochloride, ribofl avin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, taurine, L-carnitine.

† A source of arachidonic acid (ARA). PRODUCT FEATURES ‡ A source of docosahexaenoic acid (DHA). • DHA and ARA • Protein- and amino acid-free • Increased levels of B vitamins for cofactor production • Vanilla scent • Mixes easily and stays in suspension well • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2

* This product does contain taurine, a non-protein-building amino acid.

252 PFD Toddler NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 530 Biotin, mcg 47 Protein equivalent, g§ 0 Vitamin C (Ascorbic acid), mg 74 Fat, g 32 Choline, mg 135 Linoleic acid, mg 4900 Inositol, mg 109 Carbohydrate, g 60 Minerals Vitamins/Other Nutrients Calcium, mg 790 Vitamin A, IU 1840 Phosphorus, mg 530 Vitamin D, IU 450 Magnesium, mg 79 Vitamin E, IU 13.2 Iron, mg 10.5 Vitamin K, mcg 53 Zinc, mg 10.5

Thiamin (Vitamin B1), mcg 1320 Manganese, mcg 470

Riboﬂ avin (Vitamin B2), mcg 1210 Copper, mcg 1050

Vitamin B6, mcg 1210 Iodine, mcg 90

Vitamin B12, mcg 2.6 Selenium, mcg 15.8 Niacin, mcg 12100 Sodium, mg 280 Folic acid (Folacin), mcg 132 Potassium, mg 690 Pantothenic acid, mcg 4600 Chloride, mg 530

NUTRIENT FACTS Protein Equivalent (% Calories)§ 0 Osmolality (mOsm/kg water)|| 171 Fat (% Calories) 54 Osmolarity (mOsm/L)|| 154 Carbohydrate (% Calories) 46 Lactose-free Suitable for someone with lactose intolerance Potential Renal Solute Load (mOsm/100 g powder)3 62

§ This product is nutritionally incomplete since it does not contain any protein or amino acids. || Determined at 20 Cal/ﬂ oz dilution.

253 CAUTION: Mead Johnson Nutrition PFD Toddler is to be used only in the References dietary management of young children with documented amino acid 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for metabolic disorders while under direct and continuing medical supervision. Thiamin, Riboﬂ avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998:390-422. WARNING: This product is nutritionally incomplete. Care must be taken 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: to provide enough protein and amino acids to support growth using other 615-623. foods with protein as required. Medical professionals must carefully and 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11–14. constantly supervise use of PFD Toddler with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

254 PFD Toddler

Notes

255 Product Form PFD 2 PFD 2 is available in powder. For ordering information, please refer to page 301.

Composition Description/Indication Ingredients: Corn syrup solids, sugar, soy oil, modifi ed corn starch, PFD 2 is a protein- and amino acid-free product* designed to help meet the calcium phosphate and less than 1%: sodium citrate, magnesium phosphate, calorie, vitamin, mineral and essential fatty acid needs of children and adults potassium chloride, sodium phosphate, potassium citrate, choline chloride, with documented amino acid metabolic disorders. PFD 2 can be mixed with ascorbic acid, taurine, inositol, ferrous sulfate, L-carnitine, zinc sulfate, condition-specifi c amino acids or protein to make a nutritionally complete niacinamide, vitamin E acetate, calcium pantothenate, maltodextrin, cupric beverage, or it can be used as a calorie, vitamin and mineral supplement when sulfate, manganese sulfate, vitamin A palmitate, thiamin hydrochloride, amino acid and protein requirements are met but needs for calories, vitamins vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, chromic chloride, and minerals are not. Use under direct and continuing supervision of a doctor. sodium molybdate, sodium iodide, sodium selenite, biotin, vitamin K1, vitamin B12, ethyl vanillin. Product Features • Protein- and amino acid-free CAUTION: Mead Johnson Nutrition PFD 2 is to be used only in the dietary management of children and adults with documented amino acid metabolic • Suitable for someone with lactose intolerance disorders while under direct and continuing medical supervision. • Provides essential fatty acids WARNING: This product is nutritionally incomplete. Continuing medical • Convenient to use for preparing individualized protein-restricted diets supervision and frequent blood tests are required. PFD 2 must be • Vanilla scent supplemented using other food sources of protein and fl uid to support • Can be easily modifi ed with preferred fl avor enhancers dietary requirements of children and adults. • Mixes easily and stays in suspension well WARNING: Not for parenteral (I.V.) use. • Halal

* This product does contain taurine, a non-protein-building amino acid.

256 PFD 2 257 6.3 6.3 91 26 20 35 26 51 14.2 20 Powder 690 320 400 340 400 360 630 89 Suitable for someone with lactose intolerance mg

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, , Carbohydrate Carbohydrate Lactose-free Zinc Manganese Iron Magnesium Chloride Phosphorous Potassium Minerals Calcium Sodium Inositol Molybdenum Copper Iodine Chromium Vitamin C Vitamin Choline Selenium 0 11 5.1 4.8 1.19 0 Powder current information.label for Please see product are subject to change. nutrient values and ingredients Product 22 26 88 154 790 178 630 510 510 400 2600 2300 11500 Per 100 gramsPer 100 Per 100 grams † mcg

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(% Calories) , † WARNING: This product is nutritionally incomplete since it does not contain any or amino acids. protein WARNING: † Thiamin Vitamin E Vitamin K Vitamin D Vitamin A Biotin Vitamins/Other Nutrients Vitamins/Other Carbohydrate Pantothenic acid Linoleic acid Folic acid Riboﬂ Vitamin B Protein equivalent Fat Vitamin B Niacin NUTRIENT FACTS Protein Equivalent Calories Fat NUTRIENTS • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 • Halal Phenyl-Free® 1

Product Form Phenyl-Free 1 is available in powder. For ordering information, please refer to page 301. Description/Indication Phenyl-Free 1 is an iron-fortifi ed infant formula and medical food powder that is free of the essential amino acid phenylalanine for infants and Composition toddlers with documented phenylketonuria (PKU). This product provides Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, all other essential amino acids as well as nonessential amino acids, soy oil, high oleic sunfl ower oil), amino acids (L-glutamine, L-leucine, carbohydrate, fat, essential fatty acids, vitamins and minerals. Use under potassium aspartate, L-lysine hydrochloride, L-tyrosine, L-proline, direct and continuing supervision of a doctor. L-valine, L-isoleucine, L-alanine, L-arginine, L-threonine, L-serine, glycine, L-histidine, L-methionine, L-tryptophan, L-cystine), modifi ed corn starch, sugar, calcium phosphate and less than 1%: Mortierella alpina * † Product Features oil , Crypthecodinium cohnii oil , ethyl vanillin, sodium citrate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, • DHA and ARA cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline • Phenylalanine-free chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin • Vitamin and mineral levels meet the U.S. Infant Formula Act requirement B6 hydrochloride, thiamin hydrochloride, ribofl avin, vitamin D3, folic acid, per 100 Calories biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, • Increased levels of B vitamins, compared to routine infant formulas, taurine, L-carnitine. for cofactor production * A source of arachidonic acid (ARA). • Vanilla scent † A source of docosahexaenoic acid (DHA). • Mixes easily and stays in suspension well

258 Phenyl-Free® 1 259 8.6 9.6 66 86 76 14.1 38 60 Powder 440 430 660 560 240 124 380 860 350 320 Suitable for someone with lactose intolerance § mg

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, , Zinc Iron Magnesium Phosphorous Chloride Minerals Calcium Potassium Inositol Sodium Choline Manganese Copper Iodine Selenium Biotin Vitamin C Lactose-free Osmolarity Osmolality 40 47 13 144 2 Powder 40 10 51 26 16.2 current information.label for Please see product are subject to change. nutrient values and ingredients Product 380 100 500 3800 1520 4000 1000 1000 1000 Per 100 gramsPer 100 Per 100 grams 10000 3 ‡ (mOsm/100 g powder) mcg

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(% Calories) , Thiamin Vitamin K Vitamin E Vitamin D Vitamin A Pantothenic acid Vitamins/Other Nutrients Vitamins/Other Carbohydrate Folic acid Linoleic acid Ribofl Vitamin B Vitamin B Niacin Protein equivalent Fat Fat Carbohydrate Potential Renal Solute Load NUTRIENT FACTS Protein Equivalent Calories NUTRIENTS ‡ WARNING: Protein is incomplete since it does not contain the essential amino acid phenylalanine. WARNING: ‡ oz dilution. Determined at 20 Cal/fl § CAUTION: Mead Johnson Nutrition Phenyl-Free® 1 is to be used only in References the dietary management of infants and young children with documented 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Ribofl avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. phenylketonuria while under direct and continuing medical supervision. Washington, DC: National Academies Press; 1998:390-422. WARNING: This product is nutritionally incomplete. Care must be taken to 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: provide enough phenylalanine to support growth using other foods with this 615-623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. amino acid as required. Medical professionals must carefully and constantly 1999;134:11–14. supervise use of Phenyl-Free 1 with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

260 Phenyl-Free

Notes

® 1

261 Product Form Phenyl-Free 2 is available in powder. For ordering information, please refer ® Phenyl-Free 2 to page 301.

Composition Ingredients: Sugar, amino acids (L-glutamine, L-leucine, potassium Description/Indication aspartate, L-lysine hydrochloride, L-tyrosine, L-proline, L-valine, Phenyl-Free 2 is a medical food powder that is free of the essential L-isoleucine, L-alanine, L-arginine, L-threonine, L-serine, glycine, amino acid phenylalanine for children and adults with documented L-histidine, L-methionine, L-tryptophan, L-cystine), corn syrup solids, phenylketonuria (PKU). It provides all other essential amino acids as well as soy oil, modifi ed corn starch, calcium phosphate, sodium citrate, nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins magnesium phosphate, potassium chloride and less than 1%: sodium and minerals. Phenyl-Free 2 has less fat and fewer total calories than phosphate, potassium citrate, choline chloride, ascorbic acid, taurine, Phenyl-Free® 1. Use under direct and continuing supervision of a doctor. inositol, ferrous sulfate, L-carnitine, zinc sulfate, niacinamide, vitamin E acetate, vitamin A palmitate, calcium pantothenate, cupric sulfate, manganese sulfate, vitamin B12, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, chromic chloride, sodium molybdate, sodium iodide, sodium selenite, biotin, vitamin K1, ethyl vanillin. Product Features • Phenylalanine-free CAUTION: Mead Johnson Nutrition Phenyl-Free 2 is to be used only • 22 g protein equivalent/100 g powder in the dietary management of children and adults with documented • Higher level of protein equivalent than found in Phenyl-Free 1 phenylketonuria while under direct and continuing medical supervision. • Suitable for someone with lactose intolerance WARNING: This product is nutritionally incomplete. Continuing medical • Vanilla scent supervision and frequent blood tests are required. Phenyl-Free 2 must be supplemented using other food sources of protein and fl uid to provide • Can be easily modifi ed with preferred fl avor enhancers enough phenylalanine to support dietary requirements of children and adults. • Mixes easily and stays in suspension well WARNING: Not for parenteral (I.V.) use. • Halal

262 Phenyl-Free NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 410 Vitamin C (Ascorbic acid), mg 49 Protein equivalent, g* 22 Choline, mg 98 Fat, g 8.6 Inositol, mg 49

Linoleic acid, mg 4200 Minerals ® 2 Carbohydrate, g 60 Calcium, mg 730 Vitamins Phosphorous, mg 730 Vitamin A, IU 1430 Magnesium, mg 163 Vitamin D, IU 290 Iron, mg 12.2 Vitamin E, IU 9.8 Zinc, mg 12.2 Vitamin K, mcg 41 Manganese, mcg 1310

Thiamin (Vitamin B1), mcg 1220 Copper, mcg 1220

Riboﬂ avin (Vitamin B2), mcg 980 Iodine, mcg 63

Vitamin B6, mcg 980 Selenium, mcg 29

Vitamin B12, mcg 2.4 Chromium, mcg 37 Niacin, mcg 22000 Molybdenum, mcg 37 Folic acid (Folacin), mcg 350 Sodium, mg 610 Pantothenic acid, mcg 4900 Potassium, mg 1100 Biotin, mcg 49 Chloride, mg 860

NUTRIENT FACTS Protein Equivalent (% Calories)* 22 Carbohydrate (% Calories) 59 Fat (% Calories) 19 Lactose-free Suitable for someone with lactose intolerance * WARNING: Protein is incomplete since it does not contain the essential amino acid phenylalanine.

263 Product Form Phenyl-Free 2 HP is available in powder. For ordering information, Phenyl-Free® 2 HP please refer to page 301.

Composition Ingredients: Amino acids (L-glutamine, L-leucine, potassium aspartate, Description/Indication L-lysine hydrochloride, L-tyrosine, L-proline, L-valine, L-isoleucine, Phenyl-Free 2 HP is a high-protein medical food powder that is free of the L-alanine, L-arginine, L-threonine, L-serine, glycine, L-histidine, essential amino acid phenylalanine for children and adults with documented L-methionine, L-tryptophan, L-cystine), sugar, corn syrup solids, soy oil, phenylketonuria (PKU). It provides all other essential amino acids as well as modifi ed corn starch, calcium phosphate, magnesium phosphate and nonessential amino acids, carbohydrate, fat, essential fatty acids, vitamins less than 1%: sodium citrate, potassium chloride, sodium phosphate, and minerals. Phenyl-Free 2 HP is appropriate for women with maternal potassium citrate, choline chloride, ascorbic acid, taurine, inositol, ferrous PKU or for children and adults who require fewer calories than provided by sulfate, zinc sulfate, niacinamide, L-carnitine, vitamin E acetate, vitamin A Phenyl-Free® 2. Use under direct and continuing supervision of a doctor. palmitate, calcium pantothenate, cupric sulfate, manganese sulfate, vitamin B12, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, chromic chloride, sodium molybdate, sodium selenite, biotin, Product Features vitamin K1, sodium iodide, ethyl vanillin. • Phenylalanine-free • 40 g protein equivalent/100 g powder CAUTION: Mead Johnson Nutrition Phenyl-Free 2 HP is to be used only • Higher level of protein equivalent than found in Phenyl-Free 2 in the dietary management of children and adults with documented • Suitable for someone with lactose intolerance phenylketonuria while under direct and continuing medical supervision. • Vanilla scent WARNING: This product is nutritionally incomplete. Continuing medical supervision and frequent blood tests are required. Phenyl-Free 2 HP must • Can be easily modifi ed with preferred fl avor enhancers be supplemented using other food sources of protein and fl uid to provide • Mixes easily and stays in suspension well enough phenylalanine to support dietary requirements of children and adults. • Higher levels of most vitamins and minerals than found in Phenyl-Free 2 WARNING: Not for parenteral (I.V.) use. • Halal 264 Phenyl-Free® 2 HP 265 15.7 15.7 63 51 50 63 67 36 51 Powder 290 980 980 980 410 1570 1180 1570 44 Suitable for someone with lactose intolerance mg

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, , Carbohydrate Carbohydrate Lactose-free Manganese Zinc Iron Magnesium Chloride Phosphorous Potassium Minerals Calcium Sodium Inositol Molybdenum Copper Iodine Selenium Chromium Vitamin C Vitamin Choline 41 15 6.3 3.1 product label for current information. see Please to change. and ingredients are subject values Product nutrient 51 11.8 63 44 40 Powder 390 470 390 2000 6300 3000 1570 1290 1290 29000 Per 100 gramsPer 100 Per 100 grams * mcg

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(% Calories) , * amino acid phenylalanine. Protein is incomplete since it does not contain the essential WARNING: acids is more prevalent in this product t the taste of amino 2 HP, Due to the higher levels of amino acids in Phenyl-Free Note: Thiamin Vitamin K Vitamin E Vitamin D Vitamin A Biotin Vitamins/Other Nutrients Vitamins/Other Carbohydrate Pantothenic acid Linoleic acid Folic acid Riboﬂ Vitamin B Protein equivalent Fat Vitamin B Niacin Protein Equivalent Protein Equivalent NUTRIENT FACTS Calories Fat NUTRIENTS • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 • Halal TYROS 1

Product Form TYROS 1 is available in powder. For ordering information, please refer to page 301. Description/Indication TYROS 1 is an iron-fortifi ed infant formula and medical food powder that is free of the essential amino acids phenylalanine and tyrosine for infants and toddlers with documented tyrosinemia. This product provides all other Composition essential amino acids as well as nonessential amino acids, carbohydrate, Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, fat, essential fatty acids, vitamins and minerals. Use under direct and soy oil, high oleic sunfl ower oil), amino acids (L-glutamine, L-leucine, continuing supervision of a doctor. potassium aspartate, L-lysine hydrochloride, L-proline, L-valine, L-alanine, L-isoleucine, L-arginine, L-threonine, L-serine, glycine, L-histidine, L-methionine, L-tryptophan, L-cystine), modifi ed corn starch, sugar, calcium phosphate and less than 1%: Mortierella alpina oil*, Crypthecodinium cohnii Product Features oil†, ethyl vanillin, sodium citrate, potassium citrate, magnesium oxide, • DHA and ARA ferrous sulfate, potassium chloride, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline chloride, inositol, ascorbic • Phenylalanine- and tyrosine-free acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin • Vitamin and mineral levels meet the U.S. Infant Formula Act hydrochloride, ribofl avin, vitamin D3, folic acid, biotin, vitamin K1, vitamin E requirements per 100 Calories acetate, vitamin A palmitate, vitamin B12, taurine, L-carnitine. • Increased levels of B vitamins, compared to routine infant formulas, for cofactor production * A source of arachidonic acid (ARA). • Vanilla scent † A source of docosahexaenoic acid (DHA). • Mixes easily and stays in suspension well

266 TYROS 1 TYROS NUTRIENTS Product nutrient values and ingredients are subject to change. Please see product label for current information. Per 100 grams Per 100 grams Powder Powder Calories 500 Biotin, mcg 38 Protein equivalent, g‡ 16.7 Vitamin C (Ascorbic acid), mg 60 Fat, g 26 Choline, mg 124 Linoleic acid, mg 4000 Inositol, mg 86 Carbohydrate, g 51 Minerals Vitamins/Other Nutrients Calcium, mg 660 Vitamin A, IU 1520 Phosphorus, mg 440 Vitamin D, IU 380 Magnesium, mg 66 Vitamin E, IU 10 Iron, mg 9.6 Vitamin K, mcg 40 Zinc, mg 8.6

Thiamin (Vitamin B1), mcg 1000 Manganese, mcg 380

Riboﬂ avin (Vitamin B2), mcg 1000 Copper, mcg 860

Vitamin B6, mcg 1000 Iodine, mcg 76

Vitamin B12, mcg 2 Selenium, mcg 14.1 Niacin, mcg 10000 Sodium, mg 240 Folic acid (Folacin), mcg 100 Potassium, mg 610 Pantothenic acid, mcg 3800 Chloride, mg 430

NUTRIENT FACTS Protein Equivalent (% Calories)‡ 13 Osmolality (mOsm/kg water)§ 360 Fat (% Calories) 47 Osmolarity (mOsm/L)§ 320 Carbohydrate (% Calories) 40 Lactose-free Suitable for someone with lactose intolerance Potential Renal Solute Load (mOsm/100 g powder)3 148

‡ WARNING: Protein is incomplete since it does not contain the essential amino acids phenylalanine and tyrosine. § Determined at 20 Cal/ﬂ oz dilution. 267 CAUTION: Mead Johnson Nutrition TYROS 1 is to be used only in the dietary References management of infants and young children with documented tyrosinemia 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboﬂ avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. while under direct and continuing medical supervision. Washington, DC: National Academies Press;1998:390-422. WARNING: This product is nutritionally incomplete. Care must be taken to 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: provide enough phenylalanine and tyrosine to support growth using other 615-623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. foods with these amino acids as required. Medical professionals must 1999;134:11–14. carefully and constantly supervise use of TYROS 1 with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

268 TYROS 1 TYROS

Notes

269 Product Form TYROS 2 is available in powder. For ordering information, please refer to TYROS 2 page 301.

Composition Ingredients: Corn syrup solids, amino acids (L-glutamine, L-leucine, Description/Indication potassium aspartate, L-lysine hydrochloride, L-proline, L-valine, L-isoleucine, L-alanine, L-arginine, L-threonine, L-serine, glycine, L-histidine, L-methionine, TYROS 2 is an iron-fortifi ed medical food powder that is free of the L-tryptophan, L-cystine), sugar, soy oil, modifi ed corn starch, calcium essential amino acids phenylalanine and tyrosine for children and adults phosphate, sodium citrate, magnesium phosphate, potassium chloride with documented tyrosinemia. This product provides all other essential and less than 1%: sodium phosphate, potassium citrate, choline chloride, amino acids as well as nonessential amino acids, carbohydrate, fat, ascorbic acid, taurine, inositol, ferrous sulfate, L-carnitine, zinc sulfate, essential fatty acids, vitamins and minerals. Use under direct and niacinamide, vitamin E acetate, vitamin A palmitate, calcium pantothenate, continuing supervision of a doctor. cupric sulfate, manganese sulfate, vitamin B12, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, chromic chloride, sodium molybdate, sodium iodide, sodium selenite, biotin, vitamin K1, ethyl vanillin. Product Features • Phenylalanine- and tyrosine-free CAUTION: Mead Johnson Nutrition TYROS 2 is to be used only in the • 22 g protein equivalent/100 g powder dietary management of children and adults with documented inborn errors of tyrosine metabolism including tyrosinemia type II while under direct and • Higher level of protein equivalent than found in TYROS 1 continuing medical supervision. • Suitable for someone with lactose intolerance WARNING: This product is nutritionally incomplete. Continuing medical • Vanilla scent supervision and frequent blood tests are required. TYROS 2 must be • Can be easily modifi ed with preferred fl avor enhancers supplemented using other food sources of protein and fl uid to provide • Mixes easily and stays in suspension well enough tyrosine and phenylalanine to support dietary requirements of • Vitamin and mineral levels appropriate for children and adults children and adults. • Halal WARNING: Not for parenteral (I.V.) use.

270 TYROS 2 271 12.2 12.2 49 98 37 63 49 28 37 Powder 163 730 730 850 610 1300 1100 1220 59 Suitable for someone with lactose intolerance mg

mg mcg (% Calories)

, , mg mcg

, mg , mcg

mcg , , (Ascorbic acid), (Ascorbic

mg , mg

mg mg mcg ,

, , mcg , ,

, mg mg

, , Zinc Manganese Iron Magnesium Minerals Calcium Chloride Potassium Inositol Sodium Choline Molybdenum Copper Iodine Chromium Vitamin C Vitamin Selenium Lactose-free Carbohydrate Carbohydrate 19 22 9.8 8.5 2.4 Powder product label for current information. see Please to change. and ingredients are subject values Product nutrient 41 60 49 22 280 350 980 980 410 1420 4200 4900 1220 22000 Per 100 gramsPer 100 Per 100 grams * : Phosphorous mcg

), mcg

2 g* mcg (% Calories) ),

, 1 mcg

, g

mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B mcg mcg

, , avin avin g

(% Calories) , Thiamin Vitamin E Vitamin K Vitamin D Vitamin A Vitamins/Other Nutrients Vitamins/Other Carbohydrate Biotin Linoleic acid Pantothenic acid Fat Folic acid Riboﬂ Vitamin B Protein equivalent Vitamin B Niacin Fat Protein Equivalent Protein Equivalent NUTRIENT FACTS Calories NUTRIENTS * amino acids phenylalanine Protein is incomplete since it does not contain the essential and tyrosine. WARNING: • Has choline, an essential nutrient important for brain development and the normal functioning of cells1,2 WND® 1 • Halal

Product Form WND 1 is available in powder. For ordering information, please refer to Description/Indication page 301. WND 1 is an iron-fortifi ed infant formula and medical food powder that is free of nonessential amino acids for infants and toddlers with documented inborn errors of the urea cycle (waste nitrogen disorders). The product provides the essential amino acids as well as carbohydrate, fat, essential Composition fatty acids, vitamins and minerals. Use under direct and continuing Ingredients: Corn syrup solids, vegetable oil (palm olein oil, coconut oil, supervision of a doctor. soy oil, high oleic sunfl ower oil), modifi ed corn starch, sugar, amino acids (L-leucine, L-lysine hydrochloride, L-isoleucine, L-valine, L-threonine, L-tyrosine, L-phenylalanine, L-histidine, L-tryptophan, L-methionine, L-cystine), calcium phosphate and less than 1%: Mortierella alpina oil*, Product Features Crypthecodinium cohnii oil†, ethyl vanillin, potassium citrate, sodium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, • DHA and ARA cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, choline • Nonessential amino acid-free chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin • Vitamin and mineral levels meet the U.S. Infant Formula Act B6 hydrochloride, thiamin hydrochloride, ribofl avin, vitamin D3, folic acid, requirements per 100 Calories biotin, vitamin K1, vitamin E acetate, vitamin A palmitate, vitamin B12, • Increased levels of B vitamins, compared to routine infant formulas, taurine, L-carnitine. for cofactor production * A source of arachidonic acid (ARA). • Vanilla scent † A source of docosahexaenoic acid (DHA). • Mixes easily and stays in suspension well

272 WND® 1 273 8.6 9.6 66 86 76 14.1 38 60 Powder 440 420 660 560 240 124 380 860 280 250 Suitable for someone with lactose intolerance § mg

§ mg mg mcg

, , mg , (mOsm/L) (mOsm/kg water)

mcg , (Ascorbic acid),

mg , mg

mg mg mcg ,

, , 1 alone. mcg , , mcg

® , , mg mg

, , Zinc Iron Magnesium Phosphorus Chloride Minerals Calcium Potassium Inositol Sodium Choline Manganese Copper Iodine Selenium Biotin Vitamin C Lactose-free Osmolarity Osmolality 5 48 47 88 2 6.5 Powder 40 10 60 26 current information.label for Please see product are subject to change. nutrient values and ingredients Product 380 100 500 1520 3800 4000 1000 1000 1000 Per 100 gramsPer 100 Per 100 grams 10000 3 ‡ (mOsm/100 g powder) mcg

), mcg ‡

2 g mcg (% Calories) ),

, 1 mcg

, g

(% Calories) mg ,

, mcg

mcg ,

IU mcg IU IU (Vitamin B ,

(Folacin),

, 6 12 , , , (Vitamin B mcg

, avin avin g

(% Calories) , Thiamin Vitamin K Vitamin E Vitamin D Vitamin A Pantothenic acid Vitamins/Other Nutrients Vitamins/Other Carbohydrate Folic acid Linoleic acid Ribofl Vitamin B Vitamin B Niacin Protein equivalent Fat Fat Carbohydrate Protein Equivalent Protein Equivalent NUTRIENT FACTS Calories NUTRIENTS Potential Renal Solute Load ‡ WARNING: Protein level is inadequate to meet normal infant growth and development needs using WND Protein level is inadequate to meet normal infant growth and development needs using WARNING: ‡ § Determined at 20 Cal/fl oz density. oz Determined at 20 Cal/fl § CAUTION: Mead Johnson Nutrition WND® 1 is to be used only in the dietary References management of infants and young children with documented inborn errors 1. Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Ribofl avin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. or the urea cycle while under direct and continuing medical supervision. Washington, DC: National Academy Press;1998:390-422. WARNING: This product is nutritionally incomplete. Care must be taken to 2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67: provide enough calories and protein to support growth, using other foods as 615-623. 3. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. required. Medical professionals must carefully and constantly supervise use 1999;134:11–14. of WND 1 with other foods and liquids and adjust the diet based on frequent blood tests. WARNING: Not for parenteral (I.V.) use.

274 WND

Notes ® 1

275 Product Form WND 2 is available in powder. For ordering information, please refer to WND® 2 page 301.

Composition Ingredients: Corn syrup solids, amino acids (L-leucine, L-lysine Description/Indication hydrochloride, L-isoleucine, L-valine, L-threonine, L-tyrosine, L-phenylalanine, L-histidine, L-tryptophan, L-methionine, L-cystine), sugar, WND 2 is an iron-fortifi ed medical food powder that is free of nonessential soy oil, modifi ed corn starch, calcium phosphate, potassium citrate, sodium amino acids for children and adults with documented inborn errors of the citrate, magnesium phosphate, potassium chloride, sodium phosphate urea cycle (waste nitrogen disorders). The product provides the essential and less than 1%: choline chloride, ascorbic acid, taurine, inositol, ferrous amino acids as well as carbohydrate, fat, essential fatty acids, vitamins and sulfate, L-carnitine, zinc sulfate, niacinamide, vitamin E acetate, calcium minerals. Use under direct and continuing supervision of a doctor. pantothenate, maltodextrin, cupric sulfate, manganese sulfate, vitamin A palmitate, thiamin hydrochloride, vitamin B6 hydrochloride, ribofl avin, folic acid, vitamin D3, chromic chloride, sodium molybdate, sodium iodide, sodium selenite, biotin, vitamin K1, vitamin B12, ethyl vanillin. Product Features • Provides essential amino acids; does not contain nonessential CAUTION: Mead Johnson Nutrition WND 2 is to be used only in the dietary amino acids management of children and adults with documented inborn errors of the • 8.2 g protein equivalent/100 g powder urea cycle while under direct and continuing medical supervision. • Suitable for someone with lactose intolerance WARNING: This product is nutritionally incomplete. Continuing medical • Vanilla scent supervision and frequent blood tests are required. WND 2 must be • Can be easily modifi ed with preferred fl avor enhancers supplemented using other food sources of protein and fl uid to provide enough calories, vitamins and minerals to support dietary requirements of • Mixes easily and stays in suspension well children and adults. • Vitamin and mineral levels appropriate for children and adults WARNING: Not for parenteral (I.V.) use. • Halal

276 WND® 2 277 14.3 14.3 57 45 74 57 33 45 Powder 200 860 860 980 114 710 1590 1260 1430 69 Suitable for someone with lactose intolerance mg

(% Calories) mg mcg

, , mg mcg

, mg , mcg

mcg , , (Ascorbic acid), (Ascorbic

mg , mg

mg mg mcg ,

, , mcg , ,

, mg mg

, , Carbohydrate Carbohydrate Lactose-free Manganese Zinc Iron Magnesium Minerals Calcium Chloride Potassium Inositol Sodium Choline Molybdenum Copper Iodine Selenium Chromium Vitamin C Vitamin 8 23 8.2 2.9 Powder product label for current information. see Please to change. and ingredients are subject values Product nutrient 48 12.2 71 57 10.2 340 410 410 1730 5100 5700 1430 1140 1140 26000 Per 100 gramsPer 100 Per 100 grams * : Phosphorous mcg

), mcg

2 g mcg (% Calories) ),

, 1 mcg

, g

, , mg mcg

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, 6 12 , , , (Vitamin B mcg mcg

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(% Calories) , Thiamin Vitamin K Vitamin E Vitamin D Vitamins/Other Nutrients Vitamins/Other Vitamin A Carbohydrate Biotin Linoleic acid Fat Pantothenic acid Folic acid Riboﬂ Vitamin B Protein equivalent Vitamin B Niacin Protein Equivalent Protein Equivalent NUTRIENT FACTS Calories Fat NUTRIENTS * Not a source of nonessential amino acids. Notes

278 Additional Product Information Recommended Storage Guidelines for Mead Johnson Nutrition Products

Powder Storage Single-Serve Powder Packet Storage

Tubs Single-Serve Powder Packets Store powder at room temperature; avoid extreme temperatures. After Store unopened packets at room temperature. Do not freeze powder and opening, keep lid tightly closed, store in a dry area and use contents within avoid excessive heat. 1 month. Use tub with formula indicated on label only. Keep powder fresh and prevent bacterial growth by assuring tub is clean Caution and completely dry. Completely empty tub and wipe clean with a clean, dry • USE BY DATE ON PACKET cloth before reﬁ lling. If you choose to empty the pouch into the tub, you must retain the batch code and “use by” date sticker from the pouch. Ready To Use Storage Caution 2 & 6 fl oz Nursette® Bottles • USE BY DATE ON LABEL OF CURRENT POUCH Store unopened bottles at room temperature. Avoid excessive heat and prolonged exposure to light. Do not freeze. Cans Store cans at room temperature. After opening can, keep tightly covered, Caution store in dry area and use contents within 1 month. Do not freeze powder • DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED and avoid excessive heat. • DO NOT USE IF CAP RING IS BROKEN OR MISSING • USE BY DATE ON CARTON AND BOTTLE LABEL Caution • USE BY DATE ON BOTTOM OF CAN 8 & 32 fl oz Bottles Store unopened bottles at room temperature. Avoid excessive heat. Do not freeze.

280 Preparation, Usage & Storage 281 Bottles ® Human Milk Fortifier Acidified Liquid Fortifier Acidified Human Milk ® DO NOT USE IF PROTECTIVE SEAL AROUND CAP, OR IF FOIL SEAL UNDER CAP, UNDER CAP, IF FOIL SEAL OR CAP, AROUND SEAL USE IF PROTECTIVE DO NOT OR MISSING IS DAMAGED LABEL AND BOTTLE ON CARTON USE BY DATE BEEN OPENED HAS ACCEPT IF PACKAGE DO NOT OR MISSING DO NOT USE IF CAP RING IS BROKEN AND BOTTLE LABEL ON CARTON USE BY DATE Oral Electrolyte Solution Storage Oral Electrolyte Store unopened bottles at room temperature. Avoid excessive heat. Do heat. Avoid excessive Store unopened bottles at room temperature. not freeze. Caution • • • • Caution • Enfamil Store unopened pouches in carton at room temperature. Once pouch Once pouches in carton atStore unopened room temperature. and use vials inside the pouch store unused has been opened, within 24 Contents must be used within 24 hours. remaining vials Do not freeze. Avoid excessive heat. hours. 2 fl oz Nursette Liquid Human Milk Fortifier – High Liquid Human Milk Fortifier – High Human Milk Fortifier Powder Human Milk Fortifier ® ®

USE BY DATE ON TOP OF CAN ON USE BY DATE DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED HAS BEEN ACCEPT IF PACKAGE DO NOT UNDER CAP, IF FOIL SEAL OR CAP, AROUND SEAL USE IF PROTECTIVE DO NOT MISSING IS DAMAGED OR BOTTLE ON SIDE OF USE BY DATE

Human Milk Fortifier Storage Human Milk Fortifier Concentrate Storage Concentrate Enfamil Caution • not freeze. Store unopened cans at room temperature. Avoid excessive heat. Do heat. Avoid excessive Store unopened cans at room temperature. Cans • • Caution • heat. Do not freeze. heat. Store unopened fortiﬁ er bottles at room temperature. Avoid excessive at er bottles room temperature. Store unopened fortiﬁ Protein and Standard Protein Enfamil Store packets at room temperature. Avoid freezing and excessive heat.Avoid freezing and excessive Store packets at room temperature. 6 fl oz Nursette Bottles Enfamil® Probiotics Store unopened bottles at room temperature. Avoid excessive heat and Enfamil® Infant Probiotics Dietary Supplement, Enfamil® Breastfed prolonged exposure to light. Do not freeze. Infant Probiotics & Vitamin D Store in a cool, dry place. Use within 28 days once opened. Caution • DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED Caution • DO NOT USE IF CAP RING IS BROKEN OR MISSING • USE BY DATE ON BOTTOM OF CARTON • USE BY DATE ON CARTON AND BOTTLE LABEL • KEEP OUT OF REACH OF CHILDREN. BOTTLE CONTAINS TAMPER-EVIDENT SEALED LID. DO NOT USE IF BOTTLE IS DAMAGED OR HAS BEEN OPENED. 32 fl oz Bottles Store unopened bottles at room temperature or refrigerate. Avoid excessive Enfamil® Vi-Sol® Family of Vitamins heat and prolonged exposure to light. Do not freeze. Enfamil® D-Vi-Sol®, Enfamil® Poly-Vi-Sol®, Enfamil® Poly-Vi-Sol® with Iron, Enfamil® Tri-Vi-Sol®, Enfamil® Fer-In-Sol® Caution • DO NOT USE IF CAP RING IS BROKEN OR MISSING Vitamin products come with a child-resistant cap. Refrigeration not • USE BY DATE ON SIDE OF BOTTLE required. Store away from direct light.

Caution Dietary Supplements Storage • USE BY DATE ON BOTTOM OF CARTON • DO NOT USE IF PRINTED BOTTLE NECKBAND IS MISSING OR BROKEN Enfamom™ Prenatal Vitamin & Mineral Supplement Store in a cool, dry place with lid tightly closed. • DO NOT USE IF SAFETY SEAL UNDER CAP IS TORN OR MISSING

282 Preparation, Usage & Storage 283 Infants and Children with Healthy Immune Systems 2005;105:1567-1572. *,† J Am Diet Assoc. Telang S, Berseth CL, Ferguson PW, et al. Fortifying fresh human milk with Fortifying et al. PW, Ferguson Berseth CL, S, Telang

4 hours 4 hours Infants/Children Reference: 1. ers does not affect bacterial growth during 6 hours at commercial powdered human milk fortiﬁ room temperature. Neonates or Immunocompromised 1 2nd ed. 2nd ed. Infant Feedings: (commercially sterile) 4 hours 8 hours (commercially sterile) 4 hours 4 hours 2nd ed. American Dietetic Association; 2011. American Dietetic 2nd ed. • Dedicated refrigerators recommended • before feeding no longer than a total of 2 hours Hold • or discard within 1 hour Feed • after 1 hour discard If bottle is warmed, • Store at 35–40°F (2–4°C) no longer than 24 hours • Do not refrigerate for later feedings (not sterile) 4 hours 4 hours Infant Feedings: Guidelines for Preparation of Human Milk and

Product Form Recommendation Refrigeration Room temperature After feeding begins Ready-To-Use liquid unaltered infant formula infant liquid unaltered Ready-To-Use Concentrated liquid formulas formulas Powdered Powder or liquids added to liquid formulas or expressed breast milk or liquids added to liquid formulas or expressed Powder Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. Formula in Health Care Facilities. American Dietetic Association; 2011. American Dietetic Nutrition Practice Group. † For reservoir and tube-change guidelines, refer to: Robbins ST, Meyers R, eds.; Pediatric Meyers R, ST, Robbins refer to: reservoir tube-change guidelines, and For † * Adapted from: Robbins ST, Meyers R, eds.; Pediatric Nutrition Practice Group. Nutrition Practice Group. eds.; Pediatric R, Meyers Robbins ST, Adapted from: * Failure to follow these instructions could result in severe harm. Failure

Mead Johnson Nutrition Products Mead Johnson Nutrition Tube Feeding Hang Times for Hang Times for Tube Feeding

for Prepared Formula Prepared for Hospital or Institutional Storage Guidelines Guidelines Storage or Institutional Hospital Preparation of Feedings for Mead Johnson Nutrition Products

The baby’s health depends on carefully following the instructions directed and supervised by a doctor. Discuss with parents which formula is below. Use only as directed by a medical professional. Proper hygiene, appropriate for the baby. preparation, dilution, use and storage are important when preparing infant Discuss with parents whether they need to use cooled, boiled water for mixing formula. Powdered infant formulas are not sterile and should NOT be fed and whether they need to boil clean utensils, bottles and nipples in water to premature infants or infants who might have immune problems unless before use.

Powder Instructions

Enfamil PREMIUM® Newborn Enfagrow PREMIUM™ Toddler Next Step™ Enfamil NeuroPro™ Infant, Enfamil PREMIUM® Infant Enfagrow® Toddler Next Step™ and Enfamil® Infant ® ™ Enfamil Enspire Failure to follow these instructions could result in severe harm. Once ™ ® ® Enfamil NeuroPro Gentlease , Enfamil PREMIUM prepared, infant formula can spoil quickly. Either feed immediately Gentlease®, Enfamil® Gentlease® and Enfamil® Enspire™ or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than Gentlease® 24 hours. Do not use prepared formula if it is unrefrigerated for more than Enfamil NeuroPro™ Sensitive a total of 2 hours. Do not freeze prepared formula. After feeding begins, use Enfamil PREMIUM™ A2 formula within 1 hour or discard. Enfamil® Reguline® Enfamil® ProSobee® 1. Wash hands thoroughly with soap and water before preparing formula. Nutramigen® LGG®* and Nutramigen® LGG® Toddler 2. Pour desired amount of water into bottle. Add powder. Pregestimil® 3. Cap bottle and SHAKE WELL. ™ ® Enfagrow PREMIUM Toddler Transitions Use the charts on the following pages for correct amounts of water and ® ® ® Enfagrow Toddler Transitions Gentlease powder. Use scoop in tub or can to measure powder. Store DRY scoop in ® ® Enfagrow Toddler Transitions Soy lid holder in tub or in can. Enfagrow NeuroPro™ Toddler Nutritional Drink

* LGG® is a registered trademark of Chr. Hansen A/S. 284 Preparation, Usage & Storage 285 2 fl oz2 fl oz4 fl 1 unpacked level scoop oz8 fl 2 unpacked level scoops 4 unpacked level scoops 8.9 g 17.8 g 35.6 g oz2 fl oz4 fl level scoop 1 unpacked oz8 fl level scoops 2 unpacked level scoops 4 unpacked 8.8 g 17.6 g 35.2 g 2 fl oz2 fl oz4 fl 1 unpacked level scoop oz8 fl 2 unpacked level scoops 4 unpacked level scoops 8.7 g 17.4 g 34.8 g 2 fl oz2 fl oz4 fl level scoop 1 unpacked oz8 fl level scoops 2 unpacked level scoops 4 unpacked 8.8 g 17.6 g 35.2 g Water PowderWeight Water PowderWeight Water Powder Weight Water Powder Weight Sensitive A2

® ™ ® ™ * * * * Reguline ProSobee ® ® oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle 4 fl 8 fl 4 fl 8 fl 2 fl 2 fl * Each scoop adds about 0.2 fl oz to the amount of prepared formula. oz to the amount of prepared formula. * Each scoop adds about 0.2 fl To Make of prepared formula. oz to the amount about 0.2 fl * Each scoop adds To Make 4 fl 8 fl 2 fl 4 fl 8 fl 2 fl * Each scoop adds about 0.2 fl oz to the amount of prepared formula. oz to the amount of prepared formula. * Each scoop adds about 0.2 fl To Make oz to the amount of prepared formula. * Each scoop adds about 0.2 fl To Make Enfamil NeuroPro Enfamil PREMIUM Enfamil Enfamil Enfamil

® Infant ® Enfamil , ® Enfamil and Gentlease ® Infant ® ® Gentlease ™ , Enfamil PREMIUM Enfamil , ® Enspire ® 2 fl oz2 fl oz4 fl 1 unpacked level scoop oz8 fl 2 unpacked level scoops 4 unpacked level scoops 8.7 g 17.4 g 34.8 g 2 fl oz2 fl oz4 fl level scoop 1 unpacked oz8 fl level scoops 2 unpacked level scoops 4 unpacked 8.8 g 17.6 g 35.2 g 2 fl oz2 fl oz4 fl level scoop 1 unpacked oz8 fl level scoops 2 unpacked level scoops 4 unpacked 8.8 g 17.6 g 35.2 g 2 fl oz2 fl oz4 fl 1 unpacked level scoop oz8 fl 2 unpacked level scoops 4 unpacked level scoops 9 g 18 g 36 g Water Powder Weight Water Powder Weight Water Powder Weight Water PowderWeight Newborn Gentlease Infant, Enfamil PREMIUM Enfamil Infant, ® ™ ™ ™ Enfamil and * * * *

® Enspire ®

oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle oz bottle

2 fl 4 fl 8 fl 2 fl 4 fl 8 fl 2 fl 4 fl 8 fl 2 fl 4 fl 8 fl * Each scoop adds about 0.2 fl oz to the amount of prepared formula. oz to the amount of prepared formula. * Each scoop adds about 0.2 fl To Make * Each scoop adds about 0.2 fl oz to the amount of prepared formula. of prepared formula. oz to the amount * Each scoop adds about 0.2 fl To Make * Each scoop adds about 0.2 fl oz to the amount of prepared formula. of prepared formula. oz to the amount * Each scoop adds about 0.2 fl To Make * Each scoop adds about 0.2 fl oz to the amount of prepared formula. formula. oz to the amount of prepared about 0.2 fl * Each scoop adds To Make Enfamil NeuroPro Enfamil Enfamil Enfamil NeuroPro Enfamil Enfamil PREMIUM Enfamil Gentlease Nutramigen® with Enfl ora™ LGG®† Enfagrow® Toddler Transitions® Gentlease®

To Make* Water Powder Weight To Make* Water Powder Weight 2 fl oz bottle 2 fl oz 1 PACKED level scoop 9 g 6 fl oz bottle 6 fl oz 3 unpacked level scoops 27 g 4 fl oz bottle 4 fl oz 2 PACKED level scoops 18 g 8 fl oz bottle 8 fl oz 4 unpacked level scoops 36 g

8 fl oz bottle 8 fl oz 4 PACKED level scoops 36 g * Each scoop adds about 0.2 fl oz to the amount of prepared formula. * Each scoop adds about 0.2 fl oz to the amount of prepared formula. ® † LGG is a registered trademark of Chr. Hansen A/S. Enfagrow® Toddler Transitions® Soy WARNING: Do not warm. Warming may limit benefi ts of LGG culture. To Make* Water Powder Weight Nutramigen® with Enfl ora™ LGG® Toddler 6 fl oz bottle 6 fl oz 3 unpacked level scoops 28.2 g * To Make Water Powder Weight 8 fl oz bottle 8 fl oz 4 unpacked level scoops 37.6 g 6 fl oz bottle 6 fl oz 3 PACKED level scoops 27.9 g * Each scoop adds about 0.2 fl oz to the amount of prepared formula. 8 fl oz bottle 8 fl oz 4 PACKED level scoops 37.2 g * Each scoop adds about 0.2 fl oz to the amount of prepared formula. Enfagrow PREMIUM™ Toddler Next Step™ Natural Milk Flavor and WARNING: Do not warm. Warming may limit benefi ts of LGG culture. Enfagrow® Toddler Next Step™ Vanilla Pregestimil® Add 3 unpacked level scoops (1/3 cup, 36 g) of powder to 6 fl uid ounces of water. Shake well, serve immediately. Store DRY scoop in can. To Make* Water Powder Weight 2 fl oz bottle 2 fl oz 1 PACKED level scoop 8.9 g Water Powder 4 fl oz bottle 4 fl oz 2 PACKED level scoops 17.8 g Combine 6 fl oz 3 unpacked level scoops (1/3 cup, 36 g) 8 fl oz bottle 8 fl oz 4 PACKED level scoops 35.6 g

* Each scoop adds about 0.2 fl oz to the amount of prepared formula. Enfamil A.R.™ Enfagrow PREMIUM™ Toddler Transitions® Failure to follow these instructions could result in severe harm. Once * To Make Water Powder Weight prepared, infant formula can spoil quickly. Either feed immediately or cover 6 fl oz bottle 6 fl oz 3 unpacked level scoops 27 g and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not 8 fl oz bottle 8 fl oz 4 unpacked level scoops 36 g use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not

* Each scoop adds about 0.2 ﬂ oz to the amount of prepared formula. freeze prepared formula. After feeding begins, use formula within 1 hour or discard.

286 Preparation, Usage & Storage 287 oz of oz of scoop in can. scoop in can. DRY For every1 fl Jr Vanilla ™ 1 unpacked level scoop (4.5 g) level scoop 1 unpacked . It is important to follow below. the directions . * add 1 fl oz 1 fl Water Powder Add 5 unpacked level scoops (33.5 g) of powder to 5 fl oz of water to g) of powderAdd 5 unpacked level scoops (33.5 to 5 fl Jr and PurAmino ™ ™ Wash hands thoroughly with soap and waterWash preparing formula. before g of the desired level ½ cup) and 59 Add 81 g of powder (packed, bottle or container. oz (120 mL) of water in a clean carbohydrate to 4 fl Mix well with fork or mixer until a smooth paste is formed. For every make approximately 6 fl oz of prepared product. Add 7 unpacked level scoops (46.9 g) to 7 Add 7 unpacked level scoops (46.9 g) oz of prepared product. make approximately 6 fl Store oz of prepared product. oz of water to make approximately 8 fl fl water, 1 unpacked level scoop of powder (6.7 g) will make approximately 1.2 fl 1 unpacked level scoop of powder (6.7 g) will make water, prepared formula. PurAmino * If instructed to use the scoop in the can to make 30 Cal/fl oz feedings: oz feedings: in the can to make 30 Cal/fl If instructed to use the scoop * PurAmino will provideThe medical professional amount of powder to the correct for consumption mix with water amount of waterMeasure the correct suitable container for into a Jr powder. Then add the required amount of PurAmino mixing. Mix well until blended. Consume the prepared beverage immediately or cover and refrigerate. drinking. Mix before Use within 48 hours of preparation. 3232 A correct amounts doctor will provide instructions for the The child’s and leveled)A (packed One half (½) cup 3232 of water and powder. desired amount of water into Pour delivers approximately 81 g powder. Add powder and mix vigorously. bottle/container. 1. 2. 3. .

SHAKE AGAIN SHAKE Either feed scoop in lid holder. scoop in lid holder. DRY . Let bottle sit 5 minutes. sit 5 minutes. Let bottle . . 2 fl oz2 fl oz4 fl level scoop 1 unpacked oz8 fl 2 unpacked level scoops 4 unpacked level scoops 9 g 18 g 36 g Water Powder Weight SHAKE WELL SHAKE SHAKE WELL ™ oz of water, add 1 unpacked level scoop of powder oz of water, ™ * Each scoop adds about 0.1 fl oz to the amount of prepared Each scoop adds about 0.1 fl oz bottle oz bottle oz bottle Wash hands thoroughly with soap with thoroughly hands water and Wash formula. preparing before Add powder. water amount of desired into bottle. Pour Cap bottle and Wash hands thoroughly with soap and waterWash formula. before preparing Add powder. of water desired amount into bottle. Pour Cap bottle and 2 fl 4 fl 8 fl * Each scoop adds about 0.2 fl oz to the amount of prepared formula. of prepared formula. oz to the amount * Each scoop adds about 0.2 fl To Make in tub to measure powder. Store powder. in tub to measure Use the chart below for correct amounts of water and powder. Use scoop belowUse the chart for correct amounts of water and powder. 1. 1. 2. 3. Enfamil A.R. Enfamil 3 fl oz of water will make about 3.3 fl oz of formula. oz of formula. oz of water will make about 3.3 fl 3 fl formula. For example, adding 3 unpacked level scoops of powder to example, For formula. For every 1 fl (4.5 g). 1. 1. 2. 3. formula. After feeding begins, use formula within 1 hour or discard. within 1 hour or discard. use formula After feeding begins, formula. Failure to follow these instructions could result in severe harm. to follow these Failure Do not freeze prepared unrefrigerated for more than a total of 2 hours. PurAmino Do not use prepared formula if it is for no longer than 24 hours. Once prepared, infant formula can spoil quickly. infant Once prepared, immediately or cover and store in refrigerator at 35–40°F (2–4°C) 4. Add additional water to make one quart. Initial feedings of 3232 A may Failure to follow these instructions could result in severe harm. Once need to contain less than the full 59 g of carbohydrate recommended prepared, product can spoil quickly. Either consume immediately or cover or the formula may need to be diluted to 10 Calories/fl oz or less and and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. gradually increased to 20 Calories/fl oz. If incremental addition of Shake well before each use. Do not use prepared product if it is unrefrigerated carbohydrate is desired, see the table below. for more than a total of 2 hours. Do not freeze prepared product. After feeding begins, do not refrigerate the container. You must use within 1 hour or discard. Incremental Addition of Carbohydrate (CHO) to 3232 A Added CHO per 100 mL*,† (g) 0 0.1 1.2 2.1 3.2 4.1 5.2 6.1 6.2 Enfamil NeuroPro™ EnfaCare® Total CHO per 100 mL*,‡ (g) 2.8 3 4 5 6 7 8 9 9.1 CHO to add per quart (g) 0 1 11 20 30 39 49 58 59 WARNING: The baby’s health depends on carefully following the instructions Total CHO per quart of prepared formula§ (g) 27 28 38 47 57 66 76 85 86 below. Use only as directed by a medical professional. Improper hygiene, preparation, dilution, use or storage may result in severe harm. Although this Calories/fl oz of prepared formula§ 12.7 12.8 14 15.2 16.4 17.5 18.8 19.9 20 powder is formulated for infants born prematurely, powdered infant formulas * g of CHO per 100 mL = approximately % (weight volume) CHO concentration. are not sterile and should NOT be fed to premature infants or infants who † Values are for added CHO (does not include modifi ed tapioca starch present in the diet powder). ‡ Includes added CHO and modifi ed tapioca starch (stabilizer) present in the diet powder. might have immune problems unless directed and supervised by the baby’s § Prepared formula includes 81 g diet powder, the added carbohydrate and water added to make one quart. doctor. Discuss with parents which formula is appropriate for the baby. Discuss with parents the need to use cooled, boiled water for mixing and ® Portagen the need to boil clean utensils, bottles and nipples in water before use. USE AS DIRECTED BY A PHYSICIAN OR DIETITIAN. 1. Wash hands thoroughly with soap and water before preparing formula. PORTAGEN POWDER IS NOT DESIGNED FOR USE AS AN INFANT FORMULA. 2. Pour desired amount of water into the bottle. Add powder. Pour desired amount of water into a suitable container. Add powder, cover 3. Cap bottle and SHAKE WELL. container and shake vigorously until thoroughly blended. Use the chart below for correct amounts of water and powder. Use scoop in can to measure powder. Store DRY scoop in can. Portagen Enfamil NeuroPro™ EnfaCare® To Make Water Powder Weight To Make* Water Powder Weight 4.5 fl oz 4 fl oz 3 packed level scoops 28.2 g 2 fl oz bottle 2 fl oz 1 unpacked level scoop 9.8 g 2 1 quart 27 fl oz 1 ⁄3 packed level measuring cups 203 g 4 fl oz bottle 4 fl oz 2 unpacked level scoops 19.6 g Both preparations will result in 30 Calories per fl oz of prepared product. For 8 fl oz bottle 8 fl oz 4 unpacked level scoops 39.2 g other volumes, prepare as directed by a doctor. * Each scoop adds about 0.2 fl oz to the amount of prepared formula.

288 Preparation, Usage & Storage 289

DRY 14.4 15.1 14.5 14.5 Mix well untilMix well TYROS 2 Phenyl-Free 2 Phenyl-Free 2 HP WND 2 Bottles 4.5 ® 14.5 14.5 14.9 and remove cap. Do not use a microwave oven to warm formula. Serious Do not use a microwave oven to warm formula. each bottle for signs of damage. Consume the prepared beverage the prepared Consume immediately and or cover oz Nursette ﬂ Wash hands thoroughly with soap and waterWash preparing bottle before for feeding. Attach nipple unit (not included). Weight—one unpacked, level scoop (g) Weight—one Ready To Use Instructions Ready To Use Instructions BCAD 2 BCAD HCY 2 PFD Toddler PFD 2 1. Inspect 1. 2. WELL SHAKE BOTTLE 3. 4. WARNING: burns may result. 2 & 6 It is important to follow the directions below. the directions follow to important It is amount of water the correct Measure container for into a suitable of product. the required amount Then add mixing. blended. Mix before drinking. of preparation. Use within 48 hours refrigerate. the following see the chart on use the scoop in the can, If instructed to Store level scoop of product. page one unpacked, for weight of scoop in can. of powder. scoop in can. Either feed Either feed Either 1, 1, ® 2, 2, DRY ® . Store . approximately 14.5 g 2 ® Pour the required amount of waterPour 1 ® 2 HP, TYROS 2, WND TYROS 2, 2 HP, ® approximately 4.5 g of powder

formula. After feeding begins, use formula within 1 hour or discard. use formula After feeding begins, formula. unrefrigerated for more than a total of 2 hours. Do not freeze prepared unrefrigerated for more than a total of 2 hours. Once prepared, infant formula can spoil quickly. infant Once prepared, Do not use prepared formula if it is for no longer than 24 hours. powder to mix with water for consumption. Failure to follow these instructions could result in severe harm. instructions could result in severe harm. to follow these Failure immediately or cover and store in refrigerator at 35–40°F (2–4°C) The medical professional will provide the correct amount of BCAD 2, HCY 2, PFD Toddler, PFD 2, Phenyl-Free PFD 2, PFD Toddler, HCY 2, 2, BCAD * Each unpacked, level scoop of OA 2 delivers * Each unpacked, delivers If instructed to use the scoop in the can, each unpacked, level scoop each unpacked, in the can, If instructed to use the scoop bottle/container and shake vigorously. bottle/container and shake amounts of water and powder. amounts of water and powder. cap the Add the correct amount of powder, into the bottle/container. The medical professional will provideThe medical professional the correct instructions for BCAD 1, GA, HCY 1, LMD, OA 1, OA 2*, Phenyl-Free 2*, OA 1, OA LMD, HCY 1, GA, 1, BCAD Metabolic Products Metabolic formula. After feeding begins, use formula within 1 hour or discard. use formula within feeding begins, After formula. unrefrigerated for more than a total of 2 hours. Do not freeze prepared Do not freeze unrefrigerated more than a total of 2 hours. for Once prepared, infant formula can spoil quickly. can spoil formula infant Once prepared, it is formula if use prepared Do not hours. than 24 for no longer Failure to follow these instructions could result in severe harm. harm. severe in result could instructions these follow to Failure immediately store in refrigerator or cover and at (2–4°C) 35–40°F

Phenyl-Free TYROS 1, WND TYROS 1, Failure to follow these instructions could result in severe harm. WARNING: Do not use a microwave oven to warm formula. Serious burns Opened bottles can spoil quickly. Either feed immediately or replace cap may result. and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do Failure to follow these instructions could result in severe harm. not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Opened bottles and prepared formula can spoil quickly. Either feed Do not freeze. After feeding begins, use formula within 1 hour or discard. immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 48 hours. Do not use opened bottle and/or prepared formula 8 fl oz Bottles if they are unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, use prepared formula within 1 hour 1. Wash hands thoroughly with soap and water before preparing feeding or discard. bottles. 2. SHAKE BOTTLE WELL, remove protective seal around cap, remove cap Enfamil® DHA & ARA Supplement and foil seal. 3. Pour into feeding bottle(s). Inspect each bottle for signs of damage. WARNING: Do not use a microwave oven to warm formula. Serious burns This product is commercially sterile as produced. Use proper aseptic may result. Failure to follow these instructions could result in severe techniques to prevent contamination of the individual servings. harm. Opened bottles and prepared formula can spoil quickly. Either 1. Shake well and remove cap. Do not add water. feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for 2. Attach transfer lid and single use oral syringe. no longer than 48 hours. Do not use opened bottle and/or prepared formula if they are unrefrigerated for more than a total of 2 hours. Do not freeze 3. Administer volume speciﬁ ed by HCP orally or enterally. prepared formula. After feeding begins, use prepared formula within 1 hour WARNING: Do not use a microwave oven to warm contents. Serious burns or discard. may result. Upon opening, administer immediately then recap with a transfer lid and 32 fl oz Bottles store bottle in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. THIS PRODUCT SHOULD BE USED ONLY AS DIRECTED BY THE BABY’S 1. Wash hands thoroughly with soap and water before preparing DOCTOR. REFER TO HOSPITAL PROTOCOLS FOR TUBE FEEDING. feeding bottles. 2. SHAKE BOTTLE WELL, remove protective seal around cap, remove cap and foil seal. Replace cap. 3. Pour into feeding bottle(s).

290 Preparation, Usage & Storage 291

™ Either feed

Toddler Next Step Toddler Next ™ ™ Remove protective seal around cap, seal around cap, Remove protective Remove protective seal around cap, cap, Remove protective seal around Toddler Nutritional Drink Nutritional Toddler ™ Toddler Next Step Enfagrow PREMIUM Enfagrow ® Ready To Drink Instructions Instructions To Drink Ready Ready-to-Drink Natural Milk Flavor Ready-to-Drink 8 fl oz Bottle BEFORE OPENING. SHAKE WELL Keep refrigerated after opening and and serve. remove cap and foil seal, use within 5 days. 32 fl oz Bottle Keep refrigerated after opening and usewell and serve. shake Chill, within 5 days. Enfagrow Enfagrow NeuroPro Enfagrow remove cap and foil seal, and serve. Keep refrigerated after opening and and serve. remove cap and foil seal, use within 5 days. to follow these instructions could result in severe harm. Failure Ready-to-Drink Natural Milk Flavor and Natural Vanilla Natural Milk Flavor Ready-to-Drink Flavor and Flavor Ready-to-Drink Vanilla 8 fl oz Bottle SHAKE WELL BEFORE OPENING. formula can spoil quickly. infant Once prepared, immediately or cover and store in refrigerator at 35–40°F (2–4°C) prepared formula if it is Do not use for no longer than 24 hours. Do not freeze prepared unrefrigerated for more than a total of 2 hours. use formula within 1 hour or discard. After feeding begins, formula. Either feed Volume for Volume 100 Calories Formula Yield Formula and remove cap. 3.0 fl oz (89 mL)3.0 fl oz (64 mL) oz (266 mL)2.2 fl 9.0 fl oz (44 mL) oz (241 mL) oz (148 mL) 1.5 fl 8.2 fl 5.0 fl oz (27 mL) oz (221 mL) oz (134 mL) 0.9 fl 7.5 fl 4.5 fl oz (20 mL) oz (204 mL) oz (123 mL) 0.7 fl 6.9 fl 4.2 fl oz (13 mL) oz (197 mL) oz (114 mL) 0.4 fl 6.7 fl 3.8 fl oz (190 mL) oz (110 mL) 6.4 fl 3.7 fl mL) oz (106 3.6 fl (177 mL) Enfaport ™ Water to add to 6 fl oz to add to 6 fl Water Do not use a microwave oven to warm formula. Serious Do not use a microwave oven to warm formula. Although nutrient amounts per 100 Calories remain unchanged, remain unchanged, amounts per 100 Calories Although nutrient 22 24 26 27 28 20 Cal/fl oz Cal/fl Attach nipple unit (not included). Attach nipple feeding. Wash hands thoroughly with soap with hands thoroughly and waterWash bottle for preparing before Indicated See the chart below if the baby’s doctor recommends one of the doctor recommends one See the chart below if the baby’s following caloric densities: formula within 1 hour or discard. for more than a total of 2 hours. Do not freeze. After feeding begins, use After feeding begins, Do not freeze. for more than a total of 2 hours. for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated Do not use opened for no longer than 24 hours. immediately or replace cap and store in refrigerator at 35–40°F (2–4°C) Opened bottles and prepared formula can spoil quickly. Opened bottles and prepared formula can spoil quickly. Failure to follow these instructions could result in severe harm. to follow these instructions could result in severe harm. Failure burns may result. burns may result. WARNING: dilute Enfaport and for appropriate feeding volumes. 2. SHAKE BOTTLE WELL SHAKE BOTTLE 2. about the need to Consult a doctor ounce (see hcp.meadjohnson.com). 1. 1. uid diluting Enfaportwith water results in lower amounts per fl nutrient Enfaport 3. NOTE: 2. Wash hands thoroughly with soap and water before preparing bottle Single-Serve Powder Packet Instructions for feeding. 1. Wash hands thoroughly with soap and water before preparing formula. 3. Remove cap. 2. Pour desired amount of water into bottle. Pour entire contents of 4. Attach nipple unit (not included). packet(s) into bottle. WARNING: Do not use a microwave oven to warm solution. Serious burns 3. Cap bottle and SHAKE WELL. may result. Upon opening, either feed immediately or replace cap and store in Use the charts below for correct amounts of water and powder. refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not freeze. After feeding begins, use within 1 hour or discard. Enfamil NeuroPro™ Infant and Enfamil PREMIUM® Infant WARNING: Do not mix with infant formula, milk, fruit juices or other electrolyte-containing liquids. To Make* Water Powder Weight Not for parenteral (I.V.) use. 4 fl oz bottle 4 fl oz 1 packet 17.6 g 8 fl oz bottle 8 fl oz 2 packets 35.2 g This product should be used only as directed by your baby’s doctor. If vomiting or fever is present, or diarrhea continues beyond 24 hours, * Each packet adds about 0.4 fl oz to the amount of prepared formula. consult your baby’s doctor.

Enfamil® Enfalyte® Enfamil NeuroPro™ Gentlease® and Enfamil PREMIUM® Gentlease® 32 fl oz Bottles – Cherry Splash and Mixed Fruit To Make* Water Powder Weight 4 fl oz bottle 4 fl oz 1 packet 17.4 g For children under 2 years of age: Consult a doctor. 8 fl oz bottle 8 fl oz 2 packets 34.8 g For children 2 years of age and older (including adults): Offer small, frequent sips every 15–30 minutes. Increase serving as tolerated. Contact a * Each packet adds about 0.4 fl oz to the amount of prepared formula. healthcare provider if you continue to see/experience signs of dehydration. Upon opening, either feed immediately or replace cap and store in Oral Electrolyte Instructions refrigerator for no longer than 48 hours. Do not freeze. After feeding begins, use within 1 hour or discard. Enfamil® Enfalyte® 2 & 6 fl oz Nursette® Bottles – Unflavored and Cherry Flavor WARNING: Do not mix with infant formula, milk, fruit juices or other electrolyte-containing liquids. 1. Inspect each bottle for signs of damage. This product should be used only as directed by your infant’s doctor. If vomiting or fever is present, or diarrhea continues beyond 24 hours, consult your doctor. 292 Preparation, Usage & Storage

293 Improper

For bottle feeding: 50 mL25 mL 1 packet (0.71 g) 1 packet (0.71 g) Once fortifi ed human milk is prepared, it can remain at it can remain ed human milk is prepared, Once fortifi oz oz ed breast milk can spoil quickly. Liquid Human Milk Fortifiers – Liquid Human Milk Fortifiers – ® Do not use a microwave oven to warm the fortifi ed human milk. ed human milk. Do not use a microwave the fortifi oven to warm Protein and Standard Protein Protein and Standard Protein handling of human milk. handling and warm to feeding temperature.sterile container Add the powder the following the human milk according to to chart: 2 Calories/fl 4 Calories/fl for the safe instructions doctor’s or the baby’s hospital rules Follow into a desired amount the Pour agitate the human milk well. aid mixing, To • • • calories to add. Additional Calories DesiredAdditional Calories Milk Human er Enfamil Human Milk Fortifi amount of instructions for the desired doctor will provide baby’s The High Either feed fortifi ed human milk immediately or cover and store in refrigerator Either feed fortifi Agitateeach use. before at (2–4°C) for no longer than 24 hours. 35–40°F For tube feeding: room temperature for no longer than a total of 4 hours. ed human milk to be fed into a feeding only the amount of fortifi Pour ed human milk if it is fortifi Do not use container and feed immediately. use After feeding begins, unrefrigerated for more than a total of 2 hours. milk within 1 hour or discard. ed breast fortifi WARNING: the instructions health depends on carefully following The baby’s by a medical professional. Use only as directed below. Failure to follow these instructions could result in severe harm. Once instructions could result in severe harm. to follow these Failure fortifi prepared, Serious burns may result. Enfamil use or storage may result in severe harm. dilution, preparation, hygiene, • amount Improper hygiene, Improper hygiene, equal be fed to premature NOT and open. SHAKE CAN WELL SHAKE CAN Human Milk Fortifier Powder Human Milk Fortifier Powder Do not use a microwave oven to warm formula. Serious Do not use a microwave formula. oven to warm ®

Human Milk Fortiﬁ er Powder is formulated er Powder for premature infants, Human Milk Fortiﬁ ®

of concentrated liquid. Shake or stir well. Shake of concentrated liquid. Pour desired amount of water into the bottle. Add an desired amount of water the bottle. into Pour Wash hands thoroughly with soap hands thoroughly with and waterWash before preparing formula. Clean can lid,

Human Milk Fortifier Instructions Instructions Human Milk Fortifier Concentrate Instructions Instructions Concentrate Enfamil Failure to follow these instructions could result in severe harm. instructions could result in severe harm. to follow these Failure prepared formula can spoil quickly. Opened bottles or cans and Either feed immediately or cover and store in refrigerator at 35–40°F Do not use opened containers hours. (2–4°C) for no longer than 48 they are unrefrigeratedand/or prepared formula if than a total for more use After feeding begins, not freeze prepared formula. Do of 2 hours. or discard. prepared formula within 1 hour WARNING: burns may result. 3. 3. preparation, dilution, use or storage may result in severe harm. Although use or storage may result in severe harm. dilution, preparation, Enfamil The baby’s health depends on carefully following the instructions health depends on carefully following The baby’s by a medical professional. Use only as directed below. 2. 2. 1. 1. 13 fl oz Cans 13 fl nutritional powders are not sterile and should infants or infants who might have immune problems unless directed and supervised by a doctor. Follow hospital rules or the baby’s doctor’s instructions for the safe handling of Enfamil® Human Milk Fortifier Acidified Liquid breast milk. Use as directed by the baby’s doctor. This product is commercially The baby’s health depends on carefully following the instructions below. Use sterile as produced. Only use in a formulary or centralized milk preparation only as directed by a medical professional. Improper hygiene, preparation, room where there is little risk of contamination, using proper aseptic technique1. dilution, use or storage may result in Preparation may include the use of sterile containers, or sterile transfer lids and severe harm. sterile, single-use, enteral syringes. • Shake gently before using. Do not shake vigorously to minimize product • Follow hospital rules or the baby’s doctor’s instructions for the safe handling of foaming. Foaming is normal with this product. human milk. • Remove protective seal around cap, remove cap and foil seal. Add fortifi er to • To aid mixing, agitate the human milk well. Pour the desired amount into a sterile the breast milk according to the following chart for batch mixing: container and warm to feeding temperature. • Add the powder to the human milk according to the following chart: Additional Calories Desired Breast Milk Enfamil Liquid Human Milk Fortifi er Additional Calories Desired Human Milk Enfamil Human Milk Fortifi er 2 Calories/fl oz 50 mL 5 mL 2 Calories/fl oz 50 mL 1 vial 4 Calories/fl oz 25 mL 5 mL 4 Calories/fl oz 25 mL 1 vial The baby’s doctor will provide instructions for the desired amount of calories to add. Each vial of Enfamil Human Milk Fortifi er Acidifi ed Liquid is designed to deliver 5 mL when opened and Do not use product that has unusual characteristics. poured. • The baby’s doctor will provide instructions for the desired amount of calories to Failure to follow these instructions could result in severe harm. Opened add. fortifi er bottles and fortifi ed human milk can spoil quickly. Once opened, • Remove vials from foil pouch and separate number of vials needed. use immediately and discard. • Store remaining vials in foil pouch at room temperature. Once pouch has been WARNING: Do not use a microwave oven to warm the fortifi ed breast milk. opened, vials must be used within 24 hours. Serious burns may result. • Shake vial vigorously to mix contents. Firmly hold vial UPRIGHT by bottom tab and WARNING: Not for parenteral (I.V.) use. Do not administer directly—must add to slowly twist top off completely. Add fortifi er to human milk. breast milk. Some liquid may remain in cap and vial; disregard this liquid. Discard opened vial and cap promptly. Do not use product that has unusual characteristics. Reference: 1. Infant and Pediatric Feedings: Guidelines for Preparation of Human Milk and Formula Failure to follow these instructions could result in severe harm. Once prepared, in Health Care Facilities. 3rd ed.; 2018. fortifi ed breast milk can spoil quickly. Either feed fortifi ed human milk immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Agitate before each use.

294 Preparation, Usage & Storage

® 295 Poly-Vi-Sol ® ® , Enfamil , ® Fer-In-Sol ® , Enfamil , ® Poly-Vi-Sol ® Family of Vitamins Family ® Tri-Vi-Sol , Enfamil , ® ® Vi-Sol ® D-Vi-Sol ® doctor recommends another amount. doctor recommends the tip. will remain in or other foods. Shake bottle well and ﬁ ll dropper to 1 mL line (daily serving) ll dropper to unless and ﬁ Shake bottle well towards gently into mouth Dispense amount inner cheek; a small cereal juice, formula, milk, mix with breast increase acceptance, To Enfamil Drops: Drops: • • • with Iron, Enfamil with Iron, Enfamil

® Pour only the amount of fortifi ed human milk to be fed milk to ed human of fortifi amount only the Pour Once fortifi ed human milk is prepared, it can remain at prepared, ed human milk is Once fortifi

Prenatal Vitamin & Mineral Mineral Prenatal Vitamin & ™

Probiotics Not for parenteral (I.V.) use. Fortifi er is designed to be mixed er is Fortifi use. (I.V.) Not for parenteral ® Do not use a microwave oven to warm the fortifi ed human milk. milk. ed human Do not use a microwavefortifi oven to warm the Infant Probiotics Dietary Supplement, Enfamil Infant Probiotics Dietary Supplement, ® baby’s mouth or bottle baby’s mouth Dietary Supplements Instructions Instructions Dietary Supplements May be added to breast milk or formula Do not warm capRemove and turn bottle upside down to put drops into Enfamil Adults, take one softgel with food. Use only as directed. softgel with food. take one Adults, Directions for Use: Directions Supplement Supplement • • • Dispensing tips: Dispensing tips: Shake bottle well and use 6 drops once a day. Breastfed Infant Probiotics & Vitamin D Vitamin D & Infant Probiotics Breastfed Enfamom with breast milk; do not administer directly. with breast milk; WARNING: WARNING: For bottle feeding: For room temperaturehours. for no longer than a total of 4 result. Serious burns may For tube feeding: into a feeding container and feed immediately. Do not use fortifi ed human use fortifi Do not and feed immediately. container into a feeding begins, After feeding is unrefrigeratedmilk if it total of 2 hours. more than a for or discard. within 1 hour ed human milk use fortifi Enfamil Product Ordering Guide

When using this information, please note the following: • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your Coding systems and reimbursement allowable rates state provider for more information vary by payer: • Private health insurance and managed care companies may use • Medicare Part B uses HCPCS (Healthcare Common Procedure HCPCS, NDC format code or their own system—contact your provider Coding System) to group products for more information

PRODUCT ORDERING GUIDE Product Yield/ HCPCS NDC Format Product Item # Description Unit Size Calories/Unit Unit (fl oz) Case Code Code 3232 A 042521 Powder 1 lb can 2270 Varies 6 cans per case B4161 00087-0425-41 BCAD 1 892801 Powder 1 lb can 2270 Varies 6 cans per case B4162 00087-5101-84 BCAD 2 891501 Powder 1 lb can 1860 Varies 6 cans per case B4162 00087-5100-15 Enfagrow NeuroPro™ Toddler Nutritional Drink Natural Milk 177501 RTU 8 fl oz bottle 160 8 24 bottles per case XXXX 00087-5117-51 Flavor Enfagrow NeuroPro™ Toddler Nutritional Drink Natural Milk 000000 RTU 32 fl oz bottle 640 32 4 bottles per case 177502 00087-5119-61 Flavor Enfagrow NeuroPro™ Toddler 177601 RTU 8 fl oz bottle 160 8 24 bottles per case XXXX 00087-5117-54 Nutritional Drink Vanilla Enfagrow PREMIUM™ Toddler Next 167205 Powder 32 oz can 4000 173 6 cans per case B4158 00087-5114-13 Step™ Natural Milk Flavor Enfagrow PREMIUM Toddler Next 167206 Powder 24 oz can 3040 130 4 cans per case B4158 00087-1467-41 Step Natural Milk Flavor Enfagrow PREMIUM Toddler Next Step Ready-to-Drink Natural 162901 RTU 8 fl oz bottle 160 8 24 bottles per case B4158 00087-5117-51 Milk Flavor Enfagrow PREMIUM Toddler Next Step Ready-to-Drink Natural 162903 RTU 32 fl oz bottle 640 32 4 bottles per case B4158 00087-5119-61 Milk Flavor Enfagrow PREMIUM™ Toddler 169604 Powder, Refi ll 28 oz box 3940 197 4 boxes per case B4158 00087-5102-11 Transitions®

To place an order, contact your Mead Johnson representative, or call Customer Service at 1-800-457-3550. 296 Additional Product Product Information Information 297 Code NDC Format Code HCPCS Case (fl oz) (fl Unit Product Yield/ Product 086604 Dropper 50 mL N/A N/A per case 12 cartons N/A 00087-0866-44 869217 Powder157501 RTU 24 oz can oz bottle 8 fl 2470 160 130 8 per case 4 cans 24 bottles per case B4158 00087-8692-47 B4158 00087-5117-54 169602 Powder 20 oz can 2820 141 per case 4 cans B4158 00087-1401-51 194801 Dropper194701 Dropper oz bottle 0.3 fl oz bottle 0.3 fl N/A N/A N/A 48 bottles per case N/A N/A bottles per case 48 00087-5126-22 N/A 00087-5126-20 146110 Powder020135 ll Refi Powder, 20 oz can box 32.2 oz 2820 141 4540 4 cans per case 227 B4158 4 boxes per case 00087-1461-42 B4158 00087-5100-96 140916 Powder 20 oz can 2700 135 4 cans per case B4159 00087-1409-44

126105 Powder 12.8 oz can 1800 82 6 cans per case B4160 00087-5122-08 ® ® ™ ® EnfaCare

—Cherry Flavor 167503 RTU oz bottle 6 fl 22 6 24 bottles per case N/A 00087-5121-58 ® ™ ® ™ Toddler Transitions Toddler Transitions Toddler Toddler Next Step Toddler ® ® ® ® Infant Probiotics Breastfed Infant ARA Supplement DHA & 426201 RTU oz bottle 2 fl 236 2 24 bottles per case N/A 00087-5126-12 Enfalyte D-Vi-Sol 24Water 5% Glucose in 134601 RTU 166802 24 Cal RTU, oz bottle 2 fl oz bottle 2 fl 10 48 2 2 48 bottles per case 48 bottles per case N/A B4160 00087-1346-41 00087-5120-58 ® ® ® ® ® ® ® Liquid Vitamin D Supplement Vitamin Liquid Enfamil Enfagrow Toddler Next Step Toddler Enfagrow Ready-to-Drink Vanilla Enfagrow Vanilla Enfamil Enfalyte—Unfl avoredEnfamil Enfalyte—Unfl 167101 RTU oz bottle 2 fl 7.4 2 48 bottles per case N/A 00087-5115-03 Enfamil Enfalyte—Mixed Fruit 167701 RTU oz bottle 32 fl 118.4 32 6 bottles per case B4103 00087-5118-33 Enfamil Enfalyte—Cherry Splash 167501 RTU oz bottle 32 fl 118.4 32 6 bottles per case B4103 00087-5118-31 Enfamil Enfamil A.R. Enfagrow PREMIUM Toddler Toddler Enfagrow PREMIUM Transitions Product # Item Description Unit Size Calories/Unit PRODUCT ORDERING GUIDE ORDERING PRODUCT Enfagrow Dietary Supplement Enfamil Enfamil Enfamil NeuroPro Enfamil A.R.Enfamil Enfamil D Vitamin Probiotics & 153401 RTU oz bottle 8 fl 160 8 24 bottles per case B4158 00087-5103-00 Enfamil A.R. A.R. Enfamil 145301 RTU oz bottle 2 fl 40 2 48 bottles per case B4158 00087-1453-41 Enfamil A.R. A.R. Enfamil 020102 Powder 12.9 oz can 1820 91 6 cans per case B4158 00087-0201-42 Enfagrow A.R.Enfamil 020136 Powder 21.5 oz tub 3040 152 4 tubs per case B4158 00087-0201-65 Enfamil Enfamil EnfaCare 149501 RTU oz bottle 8 fl 176 8 24 bottles per case B4160 00087-5102-98 Enfamil NeuroPro EnfaCare 124902 RTU oz bottle 2 fl 44 2 48 bottles per case B4160 00087-5122-03 Soy Enfamil Gentlease N/A=Not Available * HCPCS application in progress. PRODUCT ORDERING GUIDE Product Yield/ HCPCS NDC Format Product Item # Description Unit Size Calories/Unit Unit (fl oz) Case Code Code Enfamil® Enspire™ 157401 Powder 20.5 oz tub 2940 147 4 tubs per case B4158 00087-5117-48 Enfamil® Enspire™ Gentlease® 172801 Powder 19.5 oz tub 2900 145 4 tubs per case B4158* 00087-5123-53 Enfamil® Enspire™ Gentlease® 172802 Powder, Refi ll 29 oz box 4200 210 4 boxes per case B4158* 00087-5123-55 Enfamil® Fer-In-Sol® 074026 Dropper 50 mL N/A N/A 12 cartons per case N/A 00087-0740-02 Liquid Iron Supplement Enfamil® Gentlease® 869318 Powder 29.1 oz can 4200 210 4 cans per case B4158 00087-5121-25 Enfamil Gentlease 8693Y4 Powder 20.9 oz can 3020 151 4 cans per case B4158 00087-5119-78 Enfamil Gentlease 869353 Powder 12.4 oz can 1800 90 6 cans per case B4158 00087-5100-69 Enfamil Gentlease 146401 RTU 2 fl oz bottle 40 2 48 bottles per case B4158 00087-1464-41 Enfamil Gentlease 129501 RTU 6 fl oz bottle 120 6 24 bottles per case B4158 00087-5105-23 Enfamil Gentlease 153801 RTU 8 fl oz bottle 160 8 24 bottles per case B4158 00087-5103-41 Enfamil® Human Milk Fortifi er 146301 Liquid 5 mL vial 7.5 5 mL 200 vials per case B4155 00087-1463-41 Acidifi ed Liquid Enfamil® Human Milk Fortifi er 201418 Powder 0.71 g foil sachet 3.5 — 200 units per case B4155 00087-2014-48 Powder Enfamil® Infant 1365A7 Powder 30 oz can 4300 215 4 cans per case B4158 00087-5121-27 Enfamil Infant 1365A5 Powder 21.1 oz can 3020 151 4 cans per case B4158 00087-5119-76 Enfamil Infant 136502 Powder 12.5 oz can 1800 90 6 cans per case B4158 00087-1365-42 Enfamil Infant 170901 RTU 8 fl oz bottle 160 8 24 bottles per case B4158 00087-5102-42 Enfamil Infant 172501 RTU 32 fl oz bottle 640 32 6 bottles per case B4158 00087-5121-54 Enfamil Infant 136701 Concentrate 13 fl oz can 520 26 12 cans per case B4158 00087-1367-41 ® Enfamil Liquid Human Milk 178301 Liquid 5.5 fl oz bottle 244 5.5 24 bottles per case B4155* 00087-5125-32 Fortifi er High Protein ® Enfamil Liquid Human Milk 178201 Liquid 5.5 fl oz bottle 244 5.5 24 bottles per case B4155* 00087-5125-30 Fortifi er Standard Protein Enfamil NeuroPro™ Gentlease® 133006 Powder, Refi ll 30.4 oz box 4400 220 4 boxes per case B4158 00087-5121-23 Enfamil NeuroPro Gentlease 133005 Powder 27.4 oz can 3960 198 4 cans per case B4158 00087-5121-21 Enfamil NeuroPro Gentlease 133004 Powder 20 oz tub 2900 145 4 tubs per case B4158 00087-5121-19 Enfamil NeuroPro Gentlease 133001 Single-Serve Powder Packets 17.4 g stick packs (14 per carton) 1120 56 4 cartons per case B4158 00087-5121-13 Enfamil NeuroPro™ Infant 163205 Powder, Refi ll 31.4 oz box 4500 225 4 boxes per case B4158 00087-5121-11

N/A=Not Available * HCPCS application in progress. 298 Additional Product Information PRODUCT ORDERING GUIDE Product Yield/ HCPCS NDC Format Product Item # Description Unit Size Calories/Unit Unit (fl oz) Case Code Code Enfamil NeuroPro Infant 163204 Powder 28.3 oz can 4040 202 4 cans per case B4158 00087-5121-09 Enfamil NeuroPro Infant 897204 Powder 20.7 oz tub 2960 148 6 tubs per case B4158 00087-5121-07 Enfamil NeuroPro Infant 163201 Single-Serve Powder Packets 17.6 g stick packs (14 per carton) 1120 56 4 cartons per case B4158 00087-5121-03 Enfamil NeuroPro Infant 171601 RTU 2 fl oz bottle 40 2 48 bottles per case B4158 00087-5121-29 Enfamil NeuroPro™ Infant 171901 RTU 6 fl oz bottle 120 6 24 bottles per case B4158 00087-5121-33 Enfamil NeuroPro Infant 172202 RTU 32 fl oz bottle 640 32 6 bottles per case B4158 00087-5121-41 Enfamil NeuroPro™ Sensitive 177801 Powder, Refi ll 29.4 oz box 4170 209 4 boxes per case B4158 00087-5123-53 Enfamil NeuroPro Sensitive 177802 Powder 19.5 oz tub 2770 139 6 tubs per case B4158 00087-5124-52 Enfamil® Poly-Vi-Sol® 040265 Dropper 50 mL N/A N/A 12 cartons per case N/A 00087-0402-03 Liquid Multivitamin Supplement Enfamil® Poly-Vi-Sol® with Iron 040506 Dropper 50 mL N/A N/A 12 cartons per case N/A 00087-0405-01 Liquid Multivitamin Supplement Enfamil® Premature 20 Cal 156401 RTU, 20 Cal 2 fl oz bottle 40 2 48 bottles per case B4160 00087-5115-70 Enfamil® Premature 24 Cal 156301 RTU, 24 Cal 2 fl oz bottle 48 2 48 bottles per case B4160 00087-5115-68 Enfamil® Premature 24 Cal HP 156601 RTU, 24 Cal 2 fl oz bottle 48 2 48 bottles per case B4160 00087-5115-74 Enfamil® Premature 30 Cal 156501 RTU, 30 Cal 2 fl oz bottle 60 2 48 bottles per case B4160 00087-5115-72 Enfamil PREMIUM™ A2 184801 Powder 19.5 oz tub 2800 140 6 tubs per case B4158* 00087-5126-40 Enfamil PREMIUM® Gentlease® 166408 Powder, Refi ll 32.2 oz box 4640 232 4 boxes per case B4158 00087-8693-77 Enfamil PREMIUM Gentlease 166405 Powder 21.5 oz tub 3120 156 4 tubs per case B4158 00087-8693-76 Enfamil PREMIUM Gentlease 166404 Single-Serve Powder Packets 17.4 g stick packs (14 per carton) 1120 56 4 cartons per case B4158 00087-5102-67 Enfamil PREMIUM Gentlease 169301 RTU 32 fl oz bottle 640 32 6 bottles per case B4158 00087-5115-62 Enfamil PREMIUM® Infant 161211 Powder, Refi ll 33.2 oz box 4740 237 4 boxes per case B4158 00087-1365-61 Enfamil PREMIUM Infant 161209 Powder 22.2 oz tub 3180 159 6 tubs per case B4158 00087-1365-60 Enfamil PREMIUM Infant 161208 Single-Serve Powder Packets 17.6 g stick packs (16 per carton) 1280 64 6 cartons per case B4158 00087-1365-67 Enfamil PREMIUM Infant 136601 RTU 2 fl oz bottle 40 2 48 bottles per case B4158 00087-1366-41 Enfamil PREMIUM Infant 145803 RTU 6 fl oz bottle 120 6 24 bottles per case B4158 00087-5105-21 Enfamil PREMIUM Infant 170905 RTU 8 fl oz bottle 160 8 30 bottles per case B4158 00087-5109-56 Enfamil PREMIUM Infant 169801 RTU 32 fl oz bottle 640 32 6 bottles per case B4158 00087-5115-60 Enfamil PREMIUM® Newborn 161005 Powder, Refi ll 33.2 oz box 4680 234 4 boxes per case B4158 00087-5100-42

N/A=Not Available To place an order, contact your Mead Johnson representative, or call Customer Service at 1-800-457-3550. * HCPCS application in progress. 299 PRODUCT ORDERING GUIDE Product Yield/ HCPCS NDC Format Product Item # Description Unit Size Calories/Unit Unit (fl oz) Case Code Code Enfamil PREMIUM Newborn 161003 Powder 22.2 oz tub 3120 156 4 tubs per case B4158 00087-1466-45 Enfamil PREMIUM Newborn 165701 RTU, 20 Cal 2 fl oz bottle 40 2 48 bottles per case B4158 00087-1657-41 Enfamil® ProSobee® 121460 Powder 22 oz can 3180 159 4 cans per case B4159 00087-1214-42 Enfamil ProSobee 121401 Powder 12.9 oz can 1860 93 6 cans per case B4159 00087-1214-41 Enfamil ProSobee 144901 RTU 2 fl oz bottle 40 2 48 bottles per case B4159 00087-1449-41 Enfamil ProSobee 149801 RTU 8 fl oz bottle 160 8 24 bottles per case B4159 00087-5102-50 Enfamil® ProSobee® 119501 Concentrate 13 fl oz can 520 26 12 cans per case B4159 00087-1195-41 Enfamil® Reguline® 167004 Powder 20.4 oz tub 2940 147 4 tubs per case B4158 00087-5111-57 Enfamil Reguline 167002 Powder 12.4 oz can 1800 90 6 cans per case B4158 00087-5111-32 Enfamil® Tri-Vi-Sol® 040365 Dropper 50 mL N/A N/A 12 cartons per case N/A 00087-0403-03 Liquid Vitamins Supplement Enfamil® Water for Oral Use 134501 RTU 2 fl oz bottle 0 2 48 bottles per case N/A 00087-1345-41 Enfamom™ Prenatal 470303 Softgel 1 30-count bottle N/A N/A 12 bottles per case N/A 00087-5124-80 Vitamin & Mineral Supplement Enfaport™ 129601 RTU, 30 Cal 6 fl oz bottle 180 6 24 bottles per case B4162 00087-5105-25 GA 892901 Powder 1 lb can 2270 Varies 6 cans per case B4157 or B4162 00087-5101-88 HCY 1 893301 Powder 1 lb can 2270 Varies 6 cans per case B4162 00087-5102-02 HCY 2 891901 Powder 1 lb can 1860 Varies 6 cans per case B4157 or B4162 00087-5100-27 LMD 893101 Powder 1 lb can 2270 Varies 6 cans per case B4157 or B4162 00087-5101-96 Nutramigen® 143701 RTU 2 fl oz bottle 40 2 48 bottles per case B4161 00087-1437-41 Nutramigen 429704 RTU 6 fl oz bottle 120 6 24 bottles per case B4161 00087-5105-17 Nutramigen 169101 RTU 32 fl oz bottle 640 32 6 bottles per case B4161 00087-5115-64 Nutramigen 049811 Concentrate 13 fl oz can 520 26 12 cans per case B4161 00087-0498-01 Nutramigen® with Enfl ora™ LGG®* 897309 Powder 27.8 oz can 3920 196 4 cans per case B4161 00087-5122-22 Nutramigen with Enfl ora LGG 897301 Powder 19.8 oz can 2780 139 4 cans per case B4161 00087-1239-45 Nutramigen with Enfl ora LGG 897302 Powder 12.6 oz can 1740 87 6 cans per case B4161 00087-1239-41 Nutramigen® with Enfl ora™ LGG®* 154804 Powder 12.6 oz can 1720 86 6 cans per case B4161 00087-5107-34 Toddler

* LGG® is a registered trademark of Chr. Hansen A/S. To place an order, contact your Mead Johnson representative, or call Customer Service at 1-800-457-3550.

300 Additional Product Information PRODUCT ORDERING GUIDE Product Yield/ HCPCS NDC Format Product Item # Description Unit Size Calories/Unit Unit (fl oz) Case Code Code OA 1 893201 Powder 1 lb can 2270 Varies 6 cans per case B4162 00087-5101-99 OA 2 891701 Powder 1 lb can 1860 Varies 6 cans per case B4157 or B4162 00087-5100-22 PFD 2 891601 Powder 1 lb can 1820 Varies 6 cans per case B4155 00087-5100-18 PFD Toddler 892713 Powder 14.1 oz can (400 g) 2120 Varies 6 cans per case B4155 00087-5101-78 Phenyl-Free® 1 892601 Powder 1 lb can 2270 Varies 6 cans per case B4162 00087-5101-72 Phenyl-Free® 2 891301 Powder 1 lb can 1860 Varies 6 cans per case B4157 or B4162 00087-5100-03 Phenyl-Free® 2 HP 891401 Powder 1 lb can 1770 Varies 6 cans per case B4157 or B4162 00087-5100-10 Portagen® 038722 Powder 14.46 oz can 2100 70 6 cans per case B4150 or B4158 00087-5117-28 Pregestimil® 036721 Powder 1 lb can 2240 112 6 cans per case B4161 00087-0367-01 Pregestimil 143301 RTU, 20 Cal 2 fl oz bottle 40 2 48 bottles per case B4161 00087-1433-41 Pregestimil 143401 RTU, 24 Cal 2 fl oz bottle 48 2 48 bottles per case B4161 00087-1434-41 PurAmino™ 179101 Powder 14.1 oz can (400 g) 1960 98 4 cans per case B4161* 00087-5104-80 PurAmino™ Jr 178701 Powder 14.1 oz can 1960 66 4 cans per case B4161* 00087-5122-46 PurAmino™ Jr Vanilla 178801 Powder 14.1 oz can 1960 66 4 cans per case B4161* 00087-5122-44 TYROS 1 893001 Powder 1 lb can 2270 Varies 6 cans per case B4162 00087-5101-91 TYROS 2 891801 Powder 1 lb can 1860 Varies 6 cans per case B4157 or B4162 00087-5100-24 WND® 1 893401 Powder 1 lb can 2270 Varies 6 cans per case B4162 00087-5102-05 WND® 2 892001 Powder 1 lb can 1860 Varies 6 cans per case B4157 or B4162 00087-5100-29 Accessories Please refer to page 170. Enfamil® Nutrition Kits Please refer to page 173.

* HCPCS application in progress. To place an order, contact your Mead Johnson representative, or call Customer Service at 1-800-457-3550.

301 * Enfamil NeuroPro™ Infant, Enfamil PREMIUM® Formula Dilution Instructions Infant, Enfamil® Infant, Enfamil® Enspire™, Enfamil®ProSobee®, Enfagrow® Toddler Transitions® From Powder† Gentlease®, Nutramigen® with Enfl ora™ LGG®§ Toddler Per 1 Scoop * NOTE: Powdered products are not commercially sterile and should not be fed to premature infants or immunocompromised patients, unless clinically required, and then only under strict medical supervision of preparation and use. Calories Desired Add 1 scoop powder to water Formula Yield † These dilutions can be used with the following Mead Johnson powder formulas. per fl oz‡ per mL (fl oz) (fl oz) 20 0.68 2.0 2.2 (ETTG is 2.3) Powders mix best when added on top of water. Then close the bottle and 22 0.74 1.8 2.0 shake for about 5 seconds. The number of scoops and the amount of water 24 0.81 1.6 1.9 (EPI & EE are 1.8) to add can be doubled or tripled to make a larger volume. 26 0.88 1.5 1.7 • One fl oz = 29.57 mL 27 0.91 1.4 1.7 (EPI & EE are 1.6) • One-half fl oz of water = 1 tablespoon 28 0.95 1.4 (EPI & EE are 1.3) 1.6 30 1.01 1.3 (EPI & EE are 1.2) 1.5

™ Enfamil A.R. Enfamil NeuroPro Infant, Enfamil PREMIUM Infant, Enfamil Infant, Enfamil Per 1 Scoop Enspire, Enfamil ProSobee and Enfagrow Toddler Transitions Gentlease Calories Desired Add 1 scoop powder to water Formula Yield should be measured with unpacked, level scoops. Nutramigen with Enfl ora per fl oz‡ per mL (fl oz) (fl oz) LGG Toddler should be measured with packed, level scoops. 20 0.68 2.0 2.2 • One scoop of Enfamil NeuroPro Infant, Enfamil PREMIUM Infant, Enfamil 22 0.74 1.8 2.0 Infant and Enfamil Enspire powder provides 44 Calories 24 0.81 1.6 1.9 • One scoop of Enfamil ProSobee, Enfagrow Toddler Transitions Gentlease and Nutramigen with Enfl ora LGG Toddler provides 45 Calories Enfamil A.R. should not be diluted to caloric concentrations higher than 24 Calories/fl uid ounce because of increased viscosity. Enfamil A.R. formula should be measured with unpacked, level scoops. ‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 fl oz. § LGG® is a registered trademark of Chr. Hansen A/S. • One scoop of powder provides 45 Calories ETTG = Enfagrow Toddler Transitions Gentlease EPI = Enfamil PREMIUM Infant ‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 fl oz. EE = Enfamil Enspire

302 Additional Product Information Enfagrow PREMIUM™ Toddler Transitions®, Enfagrow® Toddler Transitions® Soy Nutramigen® with Enflora™ LGG®§ Per 1 Scoop Per 1 Scoop

Calories Desired Add 1 scoop powder to water Formula Yield Calories Desired Add 1 scoop powder to water Formula Yield per fl oz‡ per mL (fl oz) (fl oz) per fl oz‡ per mL (fl oz) (fl oz) 20 0.68 2.0 2.2 (EPTT is 2.3) 20 0.68 2.0 2.3 22 0.74 1.8 2.0 (EPTT is 2.1) 22 0.74 1.9 2.1 24 0.81 1.6 (EPTT is 1.7) 1.8 (EPTT is 1.9) 24 0.81 1.7 1.9 26 0.88 1.5 1.7 (EPTT is 1.8) 26 0.88 1.5 1.8 27 0.91 1.4 (EPTT is 1.5) 1.6 (EPTT is 1.7) 27 0.91 1.5 1.7 28 0.95 1.3 (EPTT is 1.4) 1.6 28 0.95 1.4 1.6 30 1.01 1.2 (EPTT is 1.3) 1.5 30 1.01 1.3 1.5

Enfagrow PREMIUM Toddler Transitions and Enfagrow Toddler Transitions Nutramigen with Enﬂ ora LGG powder should be measured with packed, Soy should be measured with unpacked, level scoops. level scoops. • One scoop of powder provides 45 Calories • One scoop of powder provides 45 Calories

‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz. ‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz. EPTT=Enfagrow PREMIUM Toddler Transitions § LGG® is a registered trademark of Chr. Hansen A/S.

303 PurAmino™ Pregestimil® Per 1 Scoop Per 1 Scoop

Calories Desired Add 1 scoop powder to water Formula Yield Calories Desired Add 1 scoop powder to water Formula Yield per fl oz‡ per mL (fl oz) (fl oz) per fl oz‡ per mL (fl oz) (fl oz) 20 0.68 1.0 1.1 20 0.68 2.0 2.2 22 0.74 0.9 1.0 22 0.74 1.8 2.0 24 0.81 0.8 0.9 24 0.81 1.6 1.9 26 0.88 0.7 0.9 26 0.88 1.5 1.7 27 0.91 0.7 0.8 27 0.91 1.4 1.6 28 0.95 0.7 0.8 28 0.95 1.4 1.6 30 1.01 0.6 0.8 30 1.01 1.2 1.5

PurAmino powder should be measured with unpacked, level scoops. Pregestimil powder should be measured with packed, level scoops. • One scoop of powder provides 23 Calories • One scoop of powder provides 45 Calories

™ PurAmino™ Jr and PurAmino™ Jr Vanilla Enfamil PREMIUM A2 Per 1 Scoop Per 1 Scoop Calories Desired Add 1 scoop powder to water Formula Yield Calories Desired Add 1 scoop powder to water Formula Yield per fl oz‡ per mL (fl oz) (fl oz) per fl oz‡ per mL (fl oz) (fl oz) 24 0.81 1.2 1.4 20 0.68 2.0 2.2 26 0.88 1.1 1.3 22 0.74 1.8 2.0 27 0.91 1.1 1.2 24 0.81 1.6 1.9 28 0.95 1.0 1.2 27 0.91 1.4 1.7 30 1.01 1.0 1.2 30 1.01 1.3 1.5 PurAmino Jr and PurAmino Jr Vanilla formula should be measured with unpacked, level scoops. Enfamil PREMIUM A2 should be measured with unpacked, level scoops. • One scoop of powder provides 34 Calories • One scoop of powder provides 45 Calories

‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz. ‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz.

304 Additional Product Information Enfamil PREMIUM® Newborn, Enfamil NeuroPro™ Gentlease®, Enfamil PREMIUM® Gentlease®, Enfamil® Gentlease®, Enfamil® Reguline® Enfamil NeuroPro™ EnfaCare® Per 1 Scoop Per 1 Scoop

Calories Desired Add 1 scoop powder to water Formula Yield Calories Desired Add 1 scoop powder to water Formula Yield per fl oz‡ per mL (fl oz) (fl oz) per fl oz‡ per mL (fl oz) (fl oz) 20 0.68 2.0 2.2 (EPN is 2.3) 20 0.68 2.2 2.5 22 0.74 1.8 (EPN is 1.9) 2.0 (EPN is 2.1) 22 0.74 2.0 2.2 24 0.81 1.6 (EPN is 1.7) 1.8 (EPN is 1.9) 24 0.81 1.8 2.0 26 0.88 1.5 1.7 (EPN is 1.8) 26 0.88 1.6 1.9 27 0.91 1.4 (EPN is 1.5) 1.6 (EPN is 1.7) 27 0.91 1.6 1.8 28 0.95 1.4 1.6 28 0.95 1.5 1.8 30 1.01 1.3 1.5 30 1.01 1.4 1.6

Enfamil PREMIUM Newborn, Enfamil NeuroPro Gentlease, Enfamil Enfamil NeuroPro EnfaCare powder should be measured with unpacked, PREMIUM Gentlease, Enfamil Gentlease and Enfamil Reguline should be level scoops. measured with unpacked, level scoops. • One scoop of powder provides 49 Calories • One scoop of Enfamil PREMIUM Newborn powder provides 46 Calories • One scoop of Enfamil NeuroPro Gentlease, Enfamil PREMIUM Gentlease, Enfamil Gentlease and Enfamil Reguline powder provides 44 Calories

‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz EPN=Enfamil PREMIUM Newborn ‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz.

305 Enfagrow PREMIUM™ Toddler Next Step™ Natural Milk Flavor, Enfagrow® Toddler Next Step™ Vanilla Flavor Portagen® Per 1 Scoop Per 1 Scoop

Calories Desired Add 1 scoop powder to water Formula Yield Calories Desired Add 1 scoop powder to water Formula Yield per fl oz‡ per mL (fl oz) (fl oz) per fl oz‡ per mL (fl oz) (fl oz) 20 0.68 2.3 2.6 20 0.68 2.0 2.2 24 0.81 1.9 2.2 22 0.74 1.8 2.0 27 0.91 1.7 2.0 24 0.81 1.6 1.8 30 1.01 1.5 1.8 27 0.91 1.4 1.6 30 1.01 1.2 1.5 Enfagrow PREMIUM Toddler Next Step Natural Milk Flavor and Enfagrow Toddler Next Step Vanilla Flavor formula should be measured with Portagen should be measured with packed, level scoops. unpacked, level scoops. • One scoop of powder provides 44 Calories • One scoop of powder provides 53 Calories

Enfamil NeuroPro™ Sensitive Enfamil® Enspire™ Gentlease® Per 1 Scoop Per 1 Scoop

Enfamil NeuroPro Sensitive should be measured with unpacked, level scoops. Enfamil Enspire Gentlease should be measured with unpacked, level scoops. • One scoop of powder provides 45 Calories • One scoop of powder provides 44 Calories

‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz. ‡ Fluid ounce measures in the above table are rounded to the nearest 0.1 ﬂ oz.

306 Additional Product Information GRAM WEIGHTS FOR SCOOPS AND CUPS, CALORIES PER GRAM AND WATER DISPLACED BY 1 G POWDER Water (mL) Water (mL) Formula Scoop Measuring Calories/ displaced by Formula Scoop Measuring Calories/ displaced by (grams) cup (grams) gram 1 g powder (grams) cup (grams) gram 1 g powder

3232 A No Scoop 162¶,|| 5.0# 0.82 Nutramigen® with Enﬂ ora™ LGG®§ 9|| 102¶,|| 5.0 0.78 BCAD 1 4.5 114 5.0 0.77 Nutramigen® with Enﬂ ora™ LGG® 9.3|| 106¶,|| 4.8 0.74 BCAD 2 14.5 141 4.1 0.67 Toddler Enfagrow PREMIUM™ Toddler Next OA 1 4.5 112 5.0 0.76 12 108¶ 4.4 0.74 Step™ Natural Milk Flavor OA 2 14.5 140 4.1 0.68 Enfagrow PREMIUM™ Toddler 997¶ 5.1 0.78 PFD 2 14.9 136 4.0 0.65 Transitions® PFD Toddler 4.5 108 5.3 0.78 ® ™ ¶ Enfagrow Toddler Next Step Vanilla 12 108 4.4 0.73 Phenyl-Free® 1 4.5 112 5.0 0.76 Enfagrow® Toddler Transitions® Phenyl-Free® 2 14.4 140 4.1 0.67 9 108¶ 5.0 0.76 Gentlease® Phenyl-Free® 2 HP 15.1 152 3.9 0.67 ® ® ¶ Enfagrow Toddler Transitions Soy 9.4 101 4.7 0.74 Portagen® 9.4|| 122¶,|| 4.7 0.75 Enfamil A.R.™ 997¶ 5.0 0.76 Pregestimil® 8.9|| 128|| 5.0 0.78 Enfamil NeuroPro™ EnfaCare® 9.8 107¶ 5.0 0.78 PurAmino™ 4.5 115¶ 5.0 0.77 Enfamil® Enspire™ 8.8 114 5.0 0.77 PurAmino™ Jr 6.8 112 4.9 0.75 Enfamil® Enspire™ Gentlease® 8.7 108 5.0 0.77 PurAmino™ Jr Vanilla 6.8 NA 4.9 0.75 Enfamil® Gentlease® 8.7 111¶ 5.1 0.76 TYROS 1 4.5 115 5.0 0.77 Enfamil® Infant 8.8 113¶ 5.1 0.77 TYROS 2 14.5 144 4.1 0.67 Enfamil NeuroPro™ Gentlease® 8.7 111¶ 5.1 0.77 WND® 1 4.5 111 5.0 0.75 Enfamil NeuroPro™ Infant 8.8 113¶ 5.1 0.77 WND® 2 14.5 145 4.1 0.68 Enfamil NeuroPro™ Sensitive 8.9 — 5.0 0.77 Enfamil PREMIUM™ A2 8.8 — 5.1 0.77 Enfamil PREMIUM® Gentlease® 8.7 111¶ 5.1 0.77 Enfamil PREMIUM® Infant 8.8 113¶ 5.0 0.77 Enfamil PREMIUM® Newborn 9 118¶ 5.1 0.77 Enfamil® ProSobee® 8.8 101¶ 5.1 0.77 Enfamil® Reguline® 8.7 112¶ 5.1 0.76 NA = Not Available GA 4.5 114 5.0 0.77 § LGG® is a registered trademark of Chr. Hansen A/S. HCY 1 4.5 112 5.0 0.76 ¶ Values derived from grams/qt or other values. HCY 2 14.5 149 4.1 0.68 || Packed level measure. All others are unpacked level measures. # Powder only (not prepared with added ingredients). LMD 4.5 115 5.0 0.76

307 Infant Formula Nursette® Bottle Or Breast Milk Preparation

20–30 Calories per fl oz Starting with 20 Calories/fl oz, 2 fl oz (formula† or breast milk)

Choose one additive: These are general guidelines provided as a convenience. They are based on calculated results of mixing; not clinically tested. Household measures are approximations; measuring liquids in milliliters (mL), or weighing powder, Goal, Calories/fl oz provides the most accurate fi nal dilution. See page 263 for product-specifi c Formula† 22 24 27 household measure. Powder Formula‡ 0.9 g (~½ tsp) 1.8 g (~¾ tsp) 3.2 g (~1 ½ tsp) • The choices of caloric level and additions to infant formula or breast milk Enfamil PREMIUM® are clinical judgments best made by the dietitian or doctor most familiar 0.9 g (~¼ tsp) 1.8 g (~¾ tsp) 3.2 g (~1 ¼ tsp) Infant Powder Formula with the baby’s medical history and nutritional needs Concentrated Liquid 7 mL (~1 ½ tsp) 15 mL (~1 Tbsp) 32 mL (~2 Tbsp) • When choosing an appropriate addition, consider the effect on nutrient Formula§ composition and osmolality • Make changes gradually to decrease risk of intolerance • If adding Nutramigen® with Enfl ora™ LGG®*, Enfamil® ProSobee®, Enfamil A.R.™ or Pregestimil®, use only gram measurements

† Powdered products are not commercially sterile and should not be fed to premature infants or immunocompromised patients, unless clinically required, and then under direct medical supervision of preparation and use. ‡ Enfamil® Infant and Enfamil® Gentlease® powder were used for mixing to alternate dilutions. * LGG® is a registered trademark of Chr. Hansen A/S. § Enfamil Infant concentrate was used for mixing to alternate dilutions.

308 Additional Product Product Information Information 309 § 35 mL Formula milk) ed breast (~2 Tbsp + 1 tsp) (~2 Concentrated Liquid or fortifi † ¶ —— Powder Powder Formula oz (formula fl 2 oz, —— 1.4 g (~ ½ tsp)Tbsp) (~ 1 14 mL ¼ tsp) 2.8 g (~1 Water 12 mL (~2 ½ tsp) 5 mL (~1 tsp) — — oz Infant concentrate was used for mixing to alternate dilutions. 27 30 20 22 ® Goal, Goal, Calories/fl or immunocompromised patients, unless clinically required, and then under direct medical required, unless clinically or immunocompromised patients, supervision of preparation and use. † Powdered products are not commercially sterile and should not be fed to premature products are not commercially Powdered infants † Enfamil § ¶ Enfamil Infant powder formula was used for mixing to alternate dilutions. ¶ Starting with 24 Calories/fl Starting additive: Choose one § 23 mL Formula (~1 Tbsp + 1½ tsp) (~1 Concentrated Liquid ) † || Powder Powder Formula oz (formula oz, 2 fl oz, — 2.3 g (~1 tsp) — 0.9 g (~ ½ tsp)— 7 mL (~1 ½ tsp) ½ tsp) 3.8 g (~1 Tbsp) 47 mL (~3 Water 6 mL (~1 tsp) — — powder was used for mixing to alternate dilutions. ® oz Infant concentrate was used for mixing to alternate dilutions. EnfaCare ® ® 27 24 30 20 Goal, Goal, Calories/fl or immunocompromised patients, unless clinically required, and then under direct medical required, unless clinically or immunocompromised patients, supervision of preparation and use. || Enfamil || † Powdered products are not commercially sterile and should not be fed to premature products are not commercially Powdered infants † Enfamil § Starting with 22 Calories/fl Starting Choose one additive: Choose one From Concentrate*

* These dilutions can be used with the following Mead Johnson concentrate formulas.

Enfamil® Infant, Nutramigen® and Enfamil® ProSobee®

13 fl oz Can

Calories Desired Fl oz of water Formula Yield per fl oz to add to 13 fl oz can of concentrated liquid (fl oz)

20 13 26 22 10.5 23.5 24 8.5 21.5 26 720 27 619 28 5.5 18.5 30 4.5 17.5

• One 13 oz can of concentrated liquid provides 520 Calories • One ﬂ oz of undiluted concentrated liquid provides 40 Calories • One-half ﬂ oz of water = 1 tablespoon

310 Approximate Conversions Additional Product Information

POPULAR MEASURES LIQUID MEASURES U.S. Measures Metric Metric Apothecary 1 teaspoon 5 mL 1000 mL 1.06 quart

1 1 tablespoon ( ⁄2 fl oz) 15 mL 946 mL 1 quart 1 cup (8 fl oz) 237 mL 500 mL 1.06 pint 1 pint (16 fl oz) 473 mL 473 mL 1 pint 1 quart (32 fl oz) 946 mL 100 mL 3.38 fl oz 29.57 mL 1 fl oz

To convert: Milliliters to ﬂ oz, divide by 29.57 Fl oz to milliliters, multiply by 29.57

AVOIRDUPOIS TEMPERATURES U.S. Measures Metric Centigrade Fahrenheit 1 oz 28.35 g 0° Water freezes 32° 1 Ib 453.6 g 22° Room temperature 72° 2.2 Ib 1000 g (1 kilogram) 37° Body temperature 98.6° 100° Water boils 212° 121° Autoclave temperature 250°

To convert: To convert: Fahrenheit to Centigrade: Pounds to grams, multiply by 453.6 Centigrade to Fahrenheit: 1. Subtract 32 Grams to pounds, divide by 453.6 1. Multiply by 9 2. Multiply by 5 2. Divide by 5 3. Divide by 9 3. Add 32

311 Caloric Distribution

CALORIC DISTRIBUTION (% of calories) CALORIC DISTRIBUTION (% of calories) Protein Fat Carbohydrate Protein Fat Carbohydrate 3232 A (made with 81 g powder and 59 g added Enfamil® Premature 30 13 44 43 11 35 54 carbohydrate) Enfamil PREMIUM™ A2 84844 3232 A (without carbohydrate) 18 56 26 Enfamil PREMIUM® Gentlease® 94843 BCAD 1* 13 47 40 Enfamil PREMIUM® Infant 8 48 44 BCAD 2* 24 19 57 Enfamil PREMIUM® Newborn 8.5 48 43.5 Enfagrow NeuroPro™ Toddler Nutritional Drink Enfamil® ProSobee® 10 48 42 Enfagrow PREMIUM™ Toddler Next Step™ Enfamil® Reguline® 94843 16 35 49 Natural Milk Flavor Enfaport™ 14 46 40 Enfagrow PREMIUM™ Toddler Next Step™ 16 35 49 GA* 12 47 41 Ready-to-Drink – Natural Milk Flavor HCY 1* 13 47 40 Enfagrow PREMIUM™ Toddler Transitions® 10 48 42 HCY 2* 22 19 59 Enfagrow® Toddler Next Step™ – Vanilla 16 35 49 LMD* 13 47 40 Enfagrow® Toddler Next Step™ 16 35 49 Nutramigen® 11 48 41 Ready-to-Drink – Vanilla ® ™ ®‡ Enfagrow® Toddler Transitions® Gentlease® 10 48 42 Nutramigen with Enfl ora LGG 11 48 41 ® ™ ®‡ Enfagrow® Toddler Transitions® Soy 13 40 47 Nutramigen with Enfl ora LGG Toddler 10 39 51 Enfamil® 24 8.5 48 43.5 OA 1* 12 47 41 Enfamil A.R.™ 10 46 44 OA 2* 21 20 59 Enfamil NeuroPro™ EnfaCare® 11 47 42 PFD 2* 01189 Enfamil® EnfaCare® 11 47 42 PFD Toddler* 05446 ® Enfamil® Enfalyte® 0 0 100 Phenyl-Free 1* 13 47 40 ® Enfamil® Enspire™ 8.5 48 43.5 Phenyl-Free 2* 22 19 59 ® Enfamil® Enspire™ Gentlease® 94843 Phenyl-Free 2 HP* 41 15 44 ® Enfamil® Gentlease® 94843 Portagen 14 40 46 ® Enfamil® Human Milk Fortifi er Acidifi ed Liquid† 29 65 6 Pregestimil 20 2 fl oz 11 49 40 ® Enfamil® Human Milk Fortifi er Powder† 32 62 6 Pregestimil 24 Liquid & 20 Powder 11 49 40 ™ Enfamil® Infant 8 48 44 PurAmino 11 47 42 ™ Enfamil® Liquid Human Milk Fortifi er High Protein† 29 65 6 PurAmino Jr 12 44 44 ™ Enfamil® Liquid Human Milk Fortifi er Standard Protein† 22 66 12 PurAmino Jr Vanilla 12 44 44 Enfamil NeuroPro™ Gentlease® 94843 TYROS 1* 13 47 40 Enfamil NeuroPro™ Infant 8 48 44 TYROS 2* 22 19 59 Enfamil NeuroPro™ Sensitive 9 48 43 WND® 1* 54748 Enfamil® Premature 20 13 44 43 WND® 2* 82369 ® Enfamil Premature 24 13 44 43 * Protein is incomplete, since one or more of the amino acids is missing or provided in very low Enfamil® Premature 24 High Protein 14 44 42 amounts. Protein is comprised of amino acids, and the amounts are calculated as nitrogen (g) x 6.25 g of protein/g of nitrogen. † Values are for human milk fortifi er alone, not mixed with human milk. 312 ‡ LGG® is a registered trademark of Chr. Hansen A/S. Kosher and Halal Products Additional Product Information Kosher-certifi ed products will have a “U” within a circle in the product label. HALAL The following Mead Johnson Nutrition products are manufactured under the supervision of the Kashruth Division Product of the Union of Orthodox Jewish Congregations of America, and are kosher and pareve when bearing the O.U. BCAD 1 symbol of certifi cation on the label, and are kosher and contain dairy ingredients when bearing the O.U.D. BCAD 2 symbol of certifi cation on the label. Enfamil NeuroPro™ EnfaCare® Enfamil® EnfaCare® 8 fl oz Ready-to-Use Liquid KOSHER KOSHER Enfamil® Human Milk Fortifi er Powder Enfamil® Liquid Human Milk Fortifi er Product Kosher Designation Product Kosher Designation High Protein ® Enfagrow NeuroPro™ Toddler Nutritional Drink O.U.D. Enfamil® Human Milk Fortifi er Powder O.U.D. Enfamil Liquid Human Milk Fortifi er Standard Protein Enfagrow PREMIUM™ Toddler Next Step™ Natural Enfamil® Liquid Human Milk Fortifi er High Protein O.U.D. O.U.D. Enfamil® Premature 20 Cal Milk Flavor Powder Enfamil® Liquid Human Milk Fortifi er Standard Protein O.U.D. ® ™ ™ Enfamil Premature 24 Cal Enfagrow PREMIUM Toddler Next Step Natural ® O.U.D. Enfamil Infant O.U.D. Milk Flavor Ready-to-Use Enfamil® Premature High Protein 24 Cal Enfamil NeuroPro™ EnfaCare® O.U.D. Enfagrow PREMIUM™ Toddler Transitions® O.U.D. Enfamil® Premature 30 Cal Enfamil NeuroPro™ Gentlease® O.U.D. Enfagrow® Toddler Next Step™ Vanilla Powder O.U.D. GA Enfamil NeuroPro™ Infant O.U.D. Enfagrow® Toddler Next Step™ Vanilla Ready-to-Use O.U.D. HCY 1 Enfamil NeuroPro™ Sensitive O.U.D. ® ® ® HCY 2 Enfagrow Toddler Transitions Gentlease O.U.D. Enfamil® Premature 20 Cal O.U.D. ® ® Enfagrow Toddler Transitions Soy O.U. Pareve* Enfamil® Premature 24 Cal O.U.D. LMD ® Enfamil 24 O.U.D. Enfamil® Premature 24 Cal High Protein O.U.D. OA 1 Enfamil® 5% Glucose in Water O.U. Pareve* Enfamil® Premature 30 Cal O.U.D. OA 2 Enfamil A.R.™ O.U.D. Enfamil PREMIUM® Gentlease® O.U.D. PFD 2 EnfamilEnfamil® D-Vi-D-Vi-SolSol® O.U.O.U. Enfamil PREMIUM® Infant O.U.D. Phenyl-Free® 1 EnfamilEnfamil® FFer-In-Soler-In-Sol®† O.U.O.U. Enfamil PREMIUM® Newborn O.U.D. Phenyl-Free® 2 EnfamilEnfamil® Poly-Vi-SoPoly-Vi-Soll® O.U.O.U. Enfamil® ProSobee® Powder O.U. Pareve* Phenyl-Free® 2 HP EnfamilEnfamil® Poly-Vi-SoPoly-Vi-Soll® withFPOhI Iron O.U.O.U. Enfamil® Reguline® O.U.D. PurAmino™ EnfamilEnfamil® Tri-Vi-SolTri-Vi-Sol® O.U.O.U. Enfamil® Water for Oral Use O.U. Pareve* PurAmino™ Jr Enfamil® EnfaCare® O.U.D. Enfaport™ O.U.D. PurAmino™ Jr Vanilla Enfamil® Enfalyte® O.U. Pareve* Portagen® O.U.D. TYROS 1 ™ Enfamil® Enspire™ O.U.D. PurAmino O.U.D. TYROS 2 ™ Enfamil® Enspire™ Gentlease® O.U.D. PurAmino Jr O.U.D. WND® 1 ™ Enfamil® Gentlease® O.U.D. PurAmino Jr Vanilla O.U.D. WND® 2 * Pareve ingredients: manufactured on dairy equipment. † The alcohol in Enfamil Fer-In-Sol is not approved for Passover. 313 Osmolality/Osmolarity

Formula Calories Osmolality Osmolarity Formula Calories Osmolality Osmolarity /fl oz mOsm/kg water mOsm/L /fl oz mOsm/kg water mOsm/L Enfagrow NeuroPro™ Toddler Nutritional Drink Enfamil® Premature 24 Cal 24 320 280 ™ Enfagrow PREMIUM Toddler Next Step™ ® 23 N/A N/A Enfamil Premature 24 Cal High Protein 24 300 260 Natural Milk Flavor ® Enfagrow PREMIUM™ Toddler Next Step™ Enfamil Premature 30 Cal 30 320 270 20 N/A N/A Ready-to-Drink – Natural Milk Flavor Enfamil PREMIUM™ A2 20 300 270 ™ ® Enfagrow PREMIUM Toddler Transitions 20 270 240 Enfamil PREMIUM® Gentlease® Powder 20 230 210 ® ™ Enfagrow Toddler Next Step Enfamil PREMIUM® Gentlease® Ready-to-Use 23 N/A N/A 20 200 180 Vanilla (2, 6, 8 & 32 fl oz) Enfagrow® Toddler Next Step™ 20 N/A N/A ® Ready-to-Drink – Vanilla Enfamil PREMIUM Infant 20 300 270 Enfagrow® Toddler Transitions® Gentlease® 20 230 210 Enfamil PREMIUM® Newborn 20 300 270 Enfagrow® Toddler Transitions® Soy 20 230 200 Enfamil® ProSobee® Powder 20 178 160 Enfamil® 24 24 370 320 Enfamil® ProSobee® Ready-to-Use (2 fl oz) 20 200 180 Enfamil A.R.™ Powder 20 230 210 Enfamil® ProSobee® Ready-to-Use (6 & 32 fl oz) 20 170 153 ® ® ™ Enfamil ProSobee Enfamil A.R. Ready-to-Use (2 fl oz) 20 240 210 20 170 155 Concentrates & 8 fl oz Ready-to-Use Enfamil A.R.™ Ready-to-Use (8 fl oz) 20 240 210 Enfamil® Reguline® Powder 20 250 230 Enfamil NeuroPro™ EnfaCare® Powder 22 310 280 Enfaport™ 30 360 310 Enfamil NeuroPro™ EnfaCare® 22 230 200 ® Ready-to-Use (2 fl oz) Nutramigen Ready-to-Use (2 & 6 fl oz) 20 320 290 Enfamil® EnfaCare® Ready-to-Use (8 fl oz) 22 230 200 Nutramigen® Ready-to-Use (8 & 32 fl oz) 20 270 240 Enfamil® Enfalyte® Cherry Splash 3.7 200 200 Nutramigen® Concentrate 20 260 230 Enfamil® Enfalyte® Mixed Fruit 3.7 210 210 Nutramigen® with Enfl ora™ LGG®† 20 300 270 Enfamil® Enfalyte® Unfl avored 3.7 160 157 Nutramigen® with Enfl ora™ LGG®† Toddler 20 300 270 Enfamil® Enspire™ 20 300 270 Portagen® 30 350 290 Enfamil® Enspire™ Gentlease® 20 210 189 Pregestimil® Powder 20 320 280 Enfamil® Gentlease® Powder 20 220 200 Pregestimil® 20 Cal Ready-to-Use 20 290 260 Enfamil® Gentlease® Liquid 20 220 200 Pregestimil® 24 Cal Ready-to-Use 24 340 310 Enfamil® Human Milk Fortifi er High Protein 30 cal/20 mL +48 N/A PurAmino™ 20 350 320 Enfamil® Human Milk Fortifi er Standard Protein 30 cal/20 mL +48 N/A PurAmino™ Jr 30 570 480 Enfamil® Human Milk Fortifi er ™ 30 570 480 30 Cal/4 vials +36* N/A PurAmino Jr Vanilla Acidifi ed Liquid ® Enfamil Human Milk Fortifi er Powder 14 Cal/4 packets +35* N/A N/A=Not Available ® Enfamil Infant 20 300 270 Osmolalities for formulas are Mead Johnson analytical values. ® Enfamil NeuroPro™ Gentlease 20 230 210 Osmolarity is calculated from osmolality data. ™ Enfamil NeuroPro Infant 20 300 270 * Value for Enfamil Human Milk Fortifi er Acidifi ed Liquid and Enfamil Human Milk Fortifi er High Enfamil NeuroPro™ Sensitive 20 300 270 Protein Powder and Enfamil Human Fortifi er Standard Protein Powder refl ects the increase in Enfamil® Premature 20 Cal 20 260 230 osmolality when added to preterm breast milk according to directions. † LGG® is a registered trademark of Chr. Hansen A/S. 314 Additional Product Information 315 mOsm /100 mL

62 88 147 140 144 145 142 144 148 mOsm /100 Cal /100 g powder 20 21 14.2 20 18.6 12.5 20203020 23 21 2830 25 15.6 14 20 29 30 16.9 25 30 16.9 2020 25 24 16.9 15.9 20 18.6 12.5 3030 24 24 24 24 20 19.1 12.9 /ﬂ oz /ﬂ 242430 30 32 30 25 26 30 Calories * * Toddler ® ® Powder 20 21 14

® ® LGG LGG ™ ™ ora ora A2 Gentlease Infant Newborn ® Gentlease ® ™ ® ® ® ® Powder & RTU Powder RTU 20 24 25 25 16.9 20 1 with Enﬂ with Enﬂ 20 24 Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. Renal solute load and potential renal solute load in infancy. Ziegler EE. SJ, Fomon ® ® ® ®

Jr Vanilla Jr ® ®

™ ™ ™ 1.

® Premature 24 Premature 24 High Protein Premature 30 Premature ProSobee Reguline ™ PREMIUM ® ® ® ® ® 1999;134:11-14. 1 ® Pregestimil PurAmino Enfamil Enfamil Enfamil PREMIUM Ready-to-Use (32 ﬂ oz) Ready-to-Use (32 ﬂ Enfamil PREMIUM Formula Enfamil Enfamil PREMIUM Enfamil PREMIUM Enfamil Enfaport Nutramigen Nutramigen Pregestimil PurAmino Nutramigen Portagen Enfamil PurAmino Enfamil GA HCY 1 LMD OA 1 PFD Toddler Phenyl-Free METABOLIC INFANT/TODDLER FORMULAS METABOLIC INFANT/TODDLER FormulaBCAD 1 mOsm TYROS 1 WND Reference: J Pediatr. 1 90 23 mOsm /100 mL (4 packets + (EHMFAL only) (EHMFAL 100 mL of PTHM)

29 59 mOsm /100 Cal (4 packets + of EHMFAL only) of EHMFAL (per 100 Calories 100 mL of PTHM) 3.7 96 12 /ﬂ oz /ﬂ 20 26 17.6 20 21 14 20 26 17.8 202020 19.1 21 21 12.9 14.2 14 24 19.1 15.4 20 18.620 12.5 30 20 2020 33 33 22 22 20 23 15.3 2020 18.6 21 12.5 14 20 30 20 23 34 26 30 14 Calories (per 4 vials) (per 4 packets)

® ™ ™ Liquid 22 25 18.4 oz Gentlease Soy Powder 22 25 18.4 Vanilla Vanilla 23 34 26 ® ® 2 ﬂ ® ™ ™ ® ® ® er er Liquid 22 25 18.4 er High Protein Protein er Standard oz Toddler Next Step Next Toddler Toddler Next Step Next Toddler Toddler Transitions Toddler Toddler Nutritional Drink Toddler ™ ™ ™ ™ EnfaCare 8 ﬂ ® Gentlease Infant Sensitive EnfaCare Gentlease ®

™ ™ ™ ™ ™ ® ™ ™

™ Toddler Next Step Next Toddler Toddler Next Step Next Toddler Transitions Toddler Transitions Toddler PREMIUM ® ® ® ®

Premature 20 Premature Infant Human Milk Fortifi Human Milk Fortifi Enfalyte Enspire Enspire Gentlease 24 EnfaCare Human Milk Fortifi Human Milk Fortifi ® ® ® ® ® ® ® ® ® ® (with carbohydrate) (without carbohydrate) 20 12.7 39 25 16.5 16.5 ® ® is a registered trademark of Chr. Hansen A/S. A/S. Hansen is a registered trademark of Chr.

® Natural Milk Flavor Acidiﬁ ed Liquid Acidiﬁ Powder Enfagrow NeuroPro Enfagrow Enfamil Enfagrow PREMIUM Enfamil NeuroPro Enfamil Enfagrow Enfamil Enfamil Enfamil A.R. Enfamil NeuroPro Enfamil NeuroPro Enfamil Enfagrow Enfamil Enfamil Enfagrow PREMIUM Enfagrow Ready-to-Drink Vanilla Ready-to-Drink Ready-to-Drink Natural Milk Flavor Formula 3232 A 3232 A Enfamil NeuroPro Enfamil NeuroPro Enfamil Enfamil Enfamil Enfagrow

Enfamil

Enfamil Potential Renal Solute Load Solute Renal Potential * LGG Product Amino Acid Compositions

ESSENTIAL AMINO ACIDS Histidine Isoleucine Leucine Lysine mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* 3232 A — 660 — 1280 — 2200 — 1850 Enfagrow NeuroPro™ Toddler Nutritional Drink Enfagrow PREMIUM™ Toddler Next Step™ Natural Milk Flavor 116 520 210 930 400 1800 340 1500 Enfagrow PREMIUM™ Toddler Next Step™ Ready-to-Drink Natural Milk Flavor 116 520 210 930 400 1800 340 1500 Enfagrow PREMIUM™ Toddler Transitions® 75 380 135 680 260 1320 220 1100 Enfagrow® Toddler Next Step™ Vanilla 116 520 210 930 400 1800 340 1500 Enfagrow® Toddler Next Step™ Ready-to-Drink Vanilla 116 520 210 930 400 1800 340 1500 Enfagrow® Toddler Transitions® Gentlease® 65 320 151 750 280 1380 230 1160 Enfagrow® Toddler Transitions® Soy 86 410 152 720 260 1240 210 990 Enfamil® 24 48 — 128 — 230 — 200 — Enfamil A.R.™ 73 360 130 640 250 1250 210 1040 Enfamil NeuroPro™ EnfaCare® 64 320 165 830 310 1540 260 1320 Enfamil® EnfaCare® 64 320 171 850 310 1530 260 1290 Enfamil® Enspire™ Enfamil® Enspire™ Gentlease® 58 290 127 630 240 1200 210 1050 Enfamil® Gentlease® 58 290 133 680 250 1250 210 1050 Enfamil® Infant 50 250 116 590 210 1080 180 910 Enfamil® Premature 20, 24 & 30 Cal 76 — 200 — 360 — 310 — Enfamil® Premature 24 High Protein 83 — 220 — 400 — 330 — Enfamil PREMIUM™ A2 Enfamil PREMIUM® Gentlease® 58 290 133 680 250 1250 210 1050 Enfamil PREMIUM® Infant 50 250 116 590 210 1080 180 910 Enfamil PREMIUM® Newborn 48 250 128 650 230 1180 200 1000 Enfamil® ProSobee® 65 330 115 580 200 1000 158 800 Enfamil® Reguline® 58 290 133 680 250 1250 210 1050 Enfaport™ 88 — 200 — 370 — 320 — Nutramigen® 84 — 162 — 270 — 240 — Nutramigen® with Enﬂ ora™ LGG®† 84 420 162 810 270 1370 240 1180 Nutramigen® with Enﬂ ora™ LGG®† Toddler 75 360 145 700 250 1180 210 1010 Pregestimil® 84 420 162 810 270 1370 240 1180 PurAmino™ 73 360 190 950 340 1720 220 1120 PurAmino™ Jr 83 400 220 1050 390 1910 260 1240 PurAmino™ Jr Vanilla 83 400 220 1050 390 1910 260 1240

* Powder only. † LGG® is a registered trademark of Chr. Hansen A/S. 316 Additional Product Information

Methionine Cysteine Phenylalanine Tyrosine Threonine Tryptophan Valine mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* — 570 — 380 — 1080 — 590 — 1010 — 360 — 1580

100 450 36 160 200 890 200 890 184 820 56 250 250 1120 100 450 36 160 200 890 200 890 184 820 56 250 250 1120 65 330 23 118 130 660 130 660 120 600 37 185 164 830 100 450 36 160 200 890 200 890 184 820 56 250 250 1120 100 450 36 160 200 890 200 890 184 820 56 250 250 1120 60 300 47 230 109 540 104 520 159 790 46 230 159 790 73 350 41 193 175 830 125 600 129 610 48 230 155 740 46 — 48 — 80 — 74 — 145 — 41 — 128 — 63 310 23 112 125 620 125 620 115 570 35 175 158 780 62 310 62 310 109 550 104 520 190 950 52 260 168 840 62 310 64 320 106 530 98 490 193 960 54 270 171 850

48 240 48 240 99 490 76 380 147 740 34 171 136 680 53 270 42 210 97 490 92 470 140 710 40 200 140 710 46 230 36 184 84 420 80 400 122 620 35 177 122 620 73 — 76 — 125 — 116 — 230 — 64 — 200 — 79 — 83 — 137 — 126 — 250 — 69 — 220 —

53 270 42 210 97 490 92 470 140 710 40 200 140 710 46 230 36 184 84 420 80 400 122 620 35 177 122 620 46 240 48 250 80 410 74 370 145 740 41 210 128 650 63 320 31 156 133 670 95 480 98 500 37 185 118 600 53 270 42 210 97 490 92 470 140 710 40 200 140 710 81 — 64 — 147 — 140 — 210 — 61 — 210 — 73 — 48 — 137 — 59 — 129 — 46 — 200 — 73 360 48 240 137 690 59 290 129 640 46 230 200 1010 65 310 60 290 123 590 80 380 115 550 46 220 180 860 73 360 48 240 137 690 59 290 129 640 46 230 200 1010 64 320 73 360 140 700 151 760 171 850 67 340 210 1060 74 360 83 400 160 780 173 840 200 950 77 370 240 1180 74 360 83 400 160 780 173 840 200 950 77 370 240 1180 Contact Medical Services for additional details. 317 Product Amino Acid Compositions

NONESSENTIAL AMINO ACIDS Arginine Alanine Aspartic Acid Glutamic Acid mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* 3232 A — 880 — 750 — 1670 — 5100 Enfagrow NeuroPro™ Toddler Nutritional Drink Enfagrow PREMIUM™ Toddler Next Step™ Natural Milk Flavor 140 620 136 610 320 1420 880 3900 Enfagrow PREMIUM™ Toddler Next Step™ Ready-to-Drink Natural Milk Flavor 140 620 136 610 320 1420 880 3900 Enfagrow PREMIUM™ Toddler Transitions® 91 460 88 450 210 1050 570 2900 Enfagrow® Toddler Next Step™ Vanilla 140 620 136 610 320 1420 880 3900 Enfagrow® Toddler Next Step™ Ready-to-Drink Vanilla 140 620 136 610 320 1420 880 3900 Enfagrow® Toddler Transitions® Gentlease® 78 390 114 570 250 1260 520 2600 Enfagrow® Toddler Transitions® Soy 240 1160 142 680 380 1810 620 3000 Enfamil® 24 59 — 103 — 220 — 410 — Enfamil A.R.™ 88 430 85 420 200 990 550 2700 Enfamil NeuroPro™ EnfaCare® 87 430 134 670 290 1470 530 2700 Enfamil® EnfaCare® 78 390 137 680 300 1490 540 2700 Enfamil® Enspire™ Enfamil® Enspire™ Gentlease® 81 400 104 520 230 1170 440 2200 Enfamil® Gentlease® 69 350 101 510 230 1150 460 2300 Enfamil® Infant 60 300 88 440 200 990 400 2000 Enfamil® Premature 20, 24 & 30 Cal 92 — 162 — 350 — 640 — Enfamil® Premature 24 High Protein 101 — 176 — 390 — 700 — Enfamil PREMIUM™ A2 Enfamil PREMIUM® Gentlease® 69 350 101 510 230 1150 460 2300 Enfamil PREMIUM® Infant 60 300 88 440 200 990 400 2000 Enfamil PREMIUM® Newborn 59 300 103 520 220 1140 410 2100 Enfamil® ProSobee® 185 940 108 550 290 1460 470 2400 Enfamil® Reguline® 69 350 101 510 230 1150 460 2300 Enfaport™ 105 — 154 — 340 — 700 — Nutramigen® 112 — 95 — 210 — 640 — Nutramigen® with Enﬂ ora™ LGG®† 112 560 95 480 210 1060 640 3200 Nutramigen® with Enﬂ ora™ LGG®† Toddler 100 480 85 410 190 910 580 2800 Pregestimil® 112 560 95 480 210 1060 640 3200 PurAmino™ 148 740 270 1350 560 2800 168‡ 830‡ PurAmino™ Jr 164 820 300 1500 620 3100 186‡ 930‡ PurAmino™ Jr Vanilla 164 820 300 1500 620 3100 186‡ 930‡

* Powder only. † LGG® is a registered trademark of Chr. Hansen A/S. ‡ Glutamine 318 Additional Product Information

Glycine Proline Serine mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* mg/100 Cal mg/100 g* — 460 — 2300 — 1280

80 360 400 1760 230 1030 80 360 400 1760 230 1030 52 260 260 1300 151 760 80 360 400 1760 230 1030 80 360 400 1760 230 1030 52 260 210 1030 148 740 135 640 162 770 168 800 42 — 149 — 120 — 50 250 250 1230 145 720 59 290 200 980 165 830 56 280 200 990 160 790

53 260 166 830 138 690 46 230 184 940 131 670 40 200 160 810 114 580 66 — 230 — 188 — 72 — 260 — 210 —

46 230 184 940 131 670 40 200 160 810 114 580 42 210 149 760 120 610 103 520 123 620 128 650 46 230 184 940 131 670 70 — 280 — 200 — 59 — 290 — 162 — 59 290 290 1470 162 810 53 250 260 1260 145 700 59 290 290 1470 162 810 73 360 280 1390 171 850 81 400 310 1550 189 950 81 400 310 1550 189 950 Contact Medical Services for additional details. 319 Metabolic Formula Amino Acid Compositions

ESSENTIAL AMINO ACIDS Histidine Isoleucine Leucine Lysine Methionine Cysteine Phenylalanine Tyrosine Threonine Tryptophan Valine mg/100 g powder BCAD 1 550 0 0 1770 470 340 920 920 760 410 0 BCAD 2 890 0 0 2900 770 550 1490 1490 1220 650 0 GA 420 1210 2200 0 360 260 710 710 790 0 1310 HCY 1 410 1150 2100 1310 0 600 680 680 760 310 1260 HCY 2 550 1560 2900 1780 0 810 920 920 1030 420 1720 LMD 470 580 0 1510 410 290 780 780 870 340 630 OA 1 470 0 2400 1510 0 290 790 790 0 350 0 OA 2 650 0 3400 2100 0 420 1110 1110 0 480 0 PFD 2 00000000000 PFD Toddler 00000000000 Phenyl-Free® 1 410 1150 2100 1300 360 240 0 1600 750 290 1250 Phenyl-Free® 2 550 1560 2900 1760 480 330 0 2200 1010 400 1690 Phenyl-Free® 2 HP 1000 2800 5200 3200 880 600 0 4000 1840 720 3100 Portagen® 480 840 1580 1340 460 71 870 960 730 260 1090 TYROS 1 420 1200 2200 1370 370 270 0 0 780 320 1320 TYROS 2 550 1580 2900 1800 480 350 0 0 1030 420 1740 WND® 1 430 990 1930 1230 240 200 670 800 850 380 990 WND® 2 520 1190 2400 1490 300 240 800 960 1020 460 1190

320 Additional Product Information

NONESSENTI AL AMINO ACIDS Arginine Alanine Aspartic Acid Glutamic Acid Glycine Proline Serine mg/100 g powder BCAD 1 1180 1280 1560 3100 710 1560 780 BCAD 2 1730 1870 2300 4500 1030 2300 1130 GA 1040 3600 1360 0 1040 1360 710 HCY 1 990 1070 1300 2600 580 1300 650 HCY 2 1340 1450 1760 3500 790 1760 880 LMD 1100 4900 1430 0 1100 1430 750 OA 1 1000 4600 1320 0 1000 1320 690 OA 2 1340 6100 1760 0 1340 1760 920 PFD 2 0000000 PFD Toddler 0000000 Phenyl-Free® 1 970 1070 1280 2600 580 1280 630 Phenyl-Free® 2 1320 1450 1740 3500 790 1740 860 Phenyl-Free® 2 HP 2400 2600 3200 6300 1440 3200 1560 Portagen® 610 530 1200 3800 310 1800 970 TYROS 1 1100 1200 1450 2900 650 1450 720 TYROS 2 1450 1580 1910 3800 860 1910 950 WND® 1 0000000 WND® 2 0000000

Contact Medical Services for additional details.

321 Notes

322 Additional Product Information

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323 Notes

324 Additional Product Information

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325 Healthcare Professional and Consumer Resources

HEALTHCARE PROFESSIONAL RESOURCES

hcp.meadjohnson.com

Your Partner in Pediatric Nutrition The Mead Johnson Nutrition Healthcare Professional Resource Center provides information for all the Mead Johnson science-based pediatric nutrition products, as well as clinical information.

CONSUMER RESOURCES

Home Delivery for Consumers: Store Locator: enfamil.com/Shop enfamil.com/Store-Locator