Highlights of the Year
Total Page:16
File Type:pdf, Size:1020Kb

Load more
Recommended publications
-
Harnessing the Power of Precision Oncology
Cancer Advances Cleveland Clinic Cancer Center | Winter 2019 Harnessing the Power of Precision Oncology Ranked No. 5 in America for cancer care by U.S. News & World Report. Dear colleagues, Welcome to this issue of Cancer Advances. Our cover story features a sampling of our work in genetics and Advancing genomics, which is shifting the focus of questioning in oncologic research and care from tumor location to genetic mutation. Our researchers are approaching questions of cancer genetics from across the continuum, including detecting cancers at an earlier stage (p. 4), best Precision practices in testing for non-small cell lung cancer (p. 6), expanding the use of predictive assays (p. 7), treatments targeting individual tumor DNA (p. 8) and a new National Cancer Institute grant to study response prediction in Oncology radiation oncology (p. 10). Our leadership in developing the accreditation program for rectal cancer (p. 22) and the continued relevance and from Risk Prediction utility of the Khorana score (p. 14) showcase our ability to determine the line of inquiry at the national level. to Treatment Response Our multidisciplinary Sarcoma Program continues to investigate better treatments for this rare cancer while providing patients with a level of expertise matched by few centers in the United States (p. 16). Our work on potential new therapies for acute myeloid leukemia (p. 20) and breast cancer (p. 13) demonstrates the promising results of the continued pursuit of inquiry for our patients. Finally, we demonstrate our ability to ask complex questions with the work we’re pursuing on laser interstitial therapy with colleagues in the Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center (p. -
My Name Is Michael Mark Gottesman and My Position Is Deputy Director for Intramural Research at the National Institutes of Health
NHGRI: OH_Gottesman_Michael_20111113 1 3/1/16 My name is Michael Mark Gottesman and my position is deputy director for intramural research at the National Institutes of Health. I was born on October 7, 1946 in Jersey City, New Jersey. And when I was around two years old, my family moved to Flushing, Queens, and I had most of my formative years growing up in Flushing. I cannot remember a time when I wasn’t interested in science. Probably the first interaction with issues related to public health was as one of many probably millions of children in the United States who got the Salk vaccine as a -- as a test. I remember lining up, they explained to us that this was a trial, and we all got shots, which was not that much fun for a six-year-old or a seven-year-old. And that was a huge sea change. I remember learning about the fact that before then people got polio, kids got polio. They wandered off to camp, they came back paralyzed. And after that period, we didn’t need to worry about polio. So I had the sense that there was a lot that biomedical research could do to alleviate human disease. The next big event scientifically in my life was the launch of Sputnik in 1957, and it was a wake-up call to the United States. We were so-called “falling behind” in the space race, and I was an eleven-year-old boy who was interested in space science. So I spent my childhood after that making rockets, probably not as safely as it should have been, but no unfortunate accidents befell me. -
Fn Ee Rw Ms I
FN EE RW MS I FERMILAB AU.S. DEPARTMENT OF ENERGY LABORATORY CDF Central Outer Tracker 10 Photo by Reidar Hahn Volume 23 INSIDE: Friday, May 26, 2000 Number 10 2 Sensenbrenner Visits Lab f 4 The DESYÐFermilab Connection 8 Next Phase of Wilson Hall Rehab 14 Letter to the Editor 14 Symposium on Fixed Target Program at the Tevatron House Science Committee Chairman James Sensenbrenner Jr. addresses the media after his tour of Fermilab. Opposite page: viewing a model of the lab site are (from left) Associate Director for Accelerators Steve Holmes, Sensenbrenner staffer Harlan Watson, Fermilab Director Michael Witherell and Chairman Sensenbrenner. by Mike Perricone Representative James Sensenbrenner Jr., (R-Wis.), chairman of the House Science Committee, left no one in the dark about his opinion of Fermilab. ÒFermilab is the jewel in the crown of scientific institutions in the United States,Ó Rep. Sensenbrenner said after a tour of the lab on March 15, including a visit to the manufacturing facility for superconducting magnets critical to the success of the Large Hadron Collider at CERN, the European particle physics laboratory in Geneva, Switzerland. Sensenbrenner: FERMILAB HAS Critical Role in Next Machine ÒSome of the other places IÕve been, IÕve seen big managerial problems and cost overruns,Ó he continued. ÒThatÕs not the case here, and thatÕs the way we want it to be. This place is well managed. Fermilab has a mission, and it accomplishes that mission.Ó Soon after becoming chairman of the science committee, Sensenbrenner played a critical role in the 1997 negotiations leading to the $531 million agreement for U.S. -
Chironian Spring/Summer 2010
Touro Scholar The Chironian NYMC Archives Publications Spring 2010 Chironian Spring/Summer 2010 New York Medical College Follow this and additional works at: https://touroscholar.touro.edu/nymc_arch_journals Part of the Higher Education Commons, and the Medicine and Health Sciences Commons Recommended Citation New York Medical College. (2010). Chironian Spring/Summer 2010. Retrieved from https://touroscholar.touro.edu/nymc_arch_journals/61 This Book is brought to you for free and open access by the NYMC Archives Publications at Touro Scholar. It has been accepted for inclusion in The Chironian by an authorized administrator of Touro Scholar. For more information, please contact [email protected]. New York Medical c o l l e g e c h i r o N i a N S p r i N g / S u mm e r 2 0 1 0 “In the coNtiNual reMeMbraNce of a gloriouS paSt, iNdiVidualS aNd Nations fiNd their NobleSt inspiratioN.” —Sir williaM Osler, aequaNiMitaS 1 8 6 0 – 2 0 1 0 c h i r o N i a N S p r i N g / S u mm e r 2 0 1 0 FEATURES ALUMNi NEWS — A TIMELINE OF NEW YORK MEDICAL 22 NOURISHING THE BONDS THAT KEEP COLLEGE HISTORY THE COLLEGE STRONG by Donna E. Moriarty, M.P.H. ’04 and by Andrea Kott, M.P.H. Kimberly Gaudin de Gonzalez 25 SIMULATED PATIENTS, 1 A LETTER TO THE COMMUNITY REAL PRACTICE by Karl P. Adler, M.D. and Ralph A. O’Connell, M.D. by Lynda McDaniel 2 PROTECTING CHILDREN, 26 MILESTONES INFORMING CAREGIVERS by Marjorie Roberts 26 KEEPING FIRST RESPONDERS “COMMUNICADO” by Lynda McDaniel 6 COUNTERING CHEMICAL THREATS: THE FINE ART OF HARD SCIENCE HE’LL TAKE MANHATTAN (AGAIN) by Marjorie Roberts 28 by Lynda McDaniel 9 LYME DISEASE: LEADERS, LANDMARKS, AND LOOKING AHEAD 30 2010 COMMENCEMENT & REUNIONS by Cynthia A. -
NCI Budget Fact Book for Fiscal Year 1996
NCI FACT BOOK National Cancer Institute 1996 U.S. DEPARTMENT NATIONAL INSTITUTES OF HEALTH AND OF HEALTH HUMAN SERVICES The information set forth in this publication is compiled and amended annually by the financial management staff of the National Cancer Institute and is intended primarily for use by members of the Institute, principal advisory groups to the Institute and others involved in the administration and management of the National Cancer Program. Questions regarding any of the information contained herein may be directed to the Financial Management Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland, 20892. TABLE OF CONTENTS Page Organization Director's Biography ........................................ 1 Former Directors of the NCI .................................. 2 National Cancer Advisory Board .............................. 3 Division Boards of Scientific Counselors ........................ 4 President's Cancer Panel .................................... 5 Executive Committee Members ............................... 5 Organization Charts: National Cancer Institute ................................... 6 Office of the Director ...................................... 7 Division of Basic Sciences .................................. 8 Division of Clinical Sciences ................................ 9 Division of Cancer Epidemiology and Genetics ................. 10 Division of Cancer Prevention and Control .................... 11 Division of Cancer Treatment, Diagnosis and Centers ............ 12 Division of -
The Physiologist
A Publication of The American Physiological Society Experimental The Biology 2001 Abstract Physiologist Deadline Volume 43, Number 4 August 2000 November 6! EB 2001—Translating the Genome On June 26th, President Clinton walked into denced by their titles. Others will include talks the White House East Room and announced “the by leading scientists using genomics to define most wondrous map ever produced by the physiological function of a cell or a tissue. humankind.” The efforts of a public consortium However, the sessions listed are only those being led by Francis Collins and the private efforts of offered by APS. In the future, The Physiologist, Craig Venter, Celera Genomics, created a “Book the Call for Abstracts (to be mailed in of Letters,” a readout of the 3.1 billion biochem- September), and the EB and APS Home Pages ical “letters” of human DNA. These letters, will provide a listing of the wide range of ses- Inside which provide the coded instructions for a fully sions related to the “omics” listed above. functional human, will remain undecipherable However, as you are well aware, the APS por- until they are combined into words and sentences tion of the Experimental Biology meeting is not 153rd APS with meaning. just about “Translating the Genome.” It is about Business Just as APS created a new journal, all of physiology from cellular and molecular to Meeting Physiological Genomics, to provide a forum for integrative and systems to translational and clin- p. 168 the dissemination of information about the trans- ical application. It is also about professional lation of the “Book of Letters” arising from the development and social interactions. -
A Review of Judah Folkman's Remarkable Achievements
RETROSPECTIVE A review of Judah Folkman’s remarkable achievements in biomedicine Yihai Cao*† and Robert Langer‡ *Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden; and ‡Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 n January 14th of this year, the biomedical research com- munity lost Judah Folkman, O the father of angiogenesis research. Folkman’s warm and humble personality, inspirational teaching, un- limited creativity, and vast clinical expe- rience have been described elsewhere (1). Here, we focus on Folkman’s in- effaceable scientific achievements in angiogenesis research, which revolution- ized biomedical research and clinical drug development. Folkman founded an entirely new field of basic and clinical research and discovered a previously unknown family of angiogenesis regulatory molecules. He showed experimentally how these molecules provide a fundamental mech- anism that controls the growth of virtually all tumors. He showed that expansion of tissue mass, whether Judah Folkman. (Image courtesy of Jon Chase/Harvard News Office.) neoplastic or nonneoplastic, critically depends on continuous endothelial rep- This 1971 report was the first to intro- the cornea, a methodology that was crit- lication and neovascularization. duce the concept of a novel form of tu- ical for proof of angiogenic bioactivity Those discoveries paved new avenues mor dormancy caused by blockage of of a given molecule in vivo (5). His re- for the development of a new class of angiogenesis. In that paper, Folkman search also identified the existence of a drugs, angiogenesis inhibitors, which have also introduced the concept of ‘‘anti- family of angiogenic peptides (6), and already provided novel therapies for hu- angiogenesis’’ as a potential novel anti- he showed that removing an angiogenic man cancer and age-related macular cancer therapy. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
Cuadernos De Divulgación Científica Sebbm "Acércate a Nuestros Científicos 2015-2017"
CUADERNOS DE DIVULGACIÓN CIENTÍFICA SEBBM "ACÉRCATE A NUESTROS CIENTÍFICOS 2015-2017" Imagen: Pinacoteca de la Ciencia. Contaminación (probablemente un hongo) en una rodaja de cerebro en cultivo. Autor: Javier Díaz (Dpto. de Bioquímica y Biología Molecular I, Universidad Complutense de Madrid). ÍNDICE DE CONTENIDOS 1. Enero 2015: Especial Premio Nobel de Química 2014: El nanoscopio (Cristina Flors)..................................................................................................................... pp. 4-5 2. Febrero 2015: Especial Premio Nobel Medicina 2014: De disparos y oscilaciones (Liset Menéndez de la Prida)................................................................................ pp. 6-7 3. Marzo 2015: Especial Premio Nacional de Investigación en Medicina “Gregorio Marañón” 2014: Jesús Prieto: Conocer el hígado para curarlo (Carmen Berasain)............................................................................................................... pp. 8-9 4. Marzo 2015 (2): Ceramidas: no sólo en las cremas de belleza (Alicia Alonso).............................................................................................................. pp. 10-11 5. Abril 2015: Citostasis y metástasis en cáncer (Francesc Ventura)............... pp. 12-13 6. Mayo 2015: Nuevos avances en la regulación redox del ciclo de la metionina (María de los Ángeles Pajares Tarancón).................................................................... pp. 14-15 7. Junio 2015: El reloj circadiano de Arabidopsis thaliana: ¡las plantas -
Judah Folkman Judah Folkman Was Born Moses Judah Folkman in 1933
Judah Folkman Judah Folkman was born Moses Judah Folkman in 1933. The son of a rabbi, he became inspired to become a physician as a young boy when visiting ailing members of the congregation with his father. He soon became fascinated with science and medicine, and as a high school student he devised a perfusion system in his basement that maintained the viability of a beating rat heart for days after surgical removal. This led to his admission at age 15 to nearby Ohio State University, where Judah worked part-time all four years in the surgical laboratory of Dr. Robert Zollinger. He quickly mastered surgical skills and became an active participant in the exciting world of academic surgery. Judah entered Harvard Medical School at 19, where he was welcomed into the laboratory of Dr. Robert Gross, then Surgeon-in-Chief at Children’s Hospital. There, he invented the first implantable heart pacemaker. Based on his scientific contributions, Judah was elected to the AOA and received the Boylston Medical Prize, Soma Weiss Award, and Borden Undergraduate Research Award in Medicine, when he graduated magna cum laude from HMS in 1957. Judah became a surgical resident at Massachusetts General Hospital where he had his first introduction to Pediatric Surgery under the mentorship of Dr. W. Hardy Hendren. Midway through his residency, Judah married the love of his life, Paula Prial, who was to become the mother of his wonderful daughters, Marjorie and Laura, and his closest confidant for the remainder of his life. Soon thereafter, Judah enlisted in the United States Navy to fulfill his military obligations for two years. -
Judah Folkman 1933–2008
Judah Folkman 1933–2008 A Biographical Memoir by Patricia K. Donahoe ©2014 National Academy of Sciences. Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. MOSES JUDAH FOLKMAN February 24, 1933–January 14, 2008 Elected to the NAS, 1990 Moses Judah Folkman was born in 1933 in Cleveland, Ohio. He was the oldest child of a distinguished line of rabbis whose influence on the young man—particularly that of his father, Rabbi Jerome Folkman—is legendary. His mother, Bessie Schomer Folkman, instilled in him a love of science with bedtime stories about Newton, Pasteur, and Madame Curie. A move to Columbus during high school put Folkman under the tutelage of Robert Zollinger, who spotted him working at Ohio State University Hospital as a volunteer aide and invited him to work in his laboratory afternoons and weekends. There in the Zollinger Laboratory, where he worked throughout college, Folkman had the oppor- By Patricia K. Donahoe tunity to learn surgical skills and published a paper about liver cooling in the journal Surgery. He was accepted at Harvard Medical School in 1953 and worked in the laboratories of Robert E. Gross, from whom he learned the “obsessive perseverance” required for his future life as a surgeon scientist. Folkman also helped to develop a heart-lung bubble oxygenator, which was initially used for repair of ventricular septal defects, and he designed a prototype transistorized pacemaker with Massachusetts Institute of Technology graduate student Fred Vanderschmidt. The heart lung machine and the pacemaker, though perfected in other laboratories, provided the tools to realize Gross’s dream of innovating and making cardiac surgery routine for infants and children (Cooke 2001). -
SPRING 2014 Message from the Dean
SPRING 2014 Message from the Dean Over my nearly seven years at Duke, change has ing and the new Cancer Center and Duke Medicine DukeMed Alumni News been the rule, not the exception. When I first came Pavilion in spite of a severe economic downturn and is published two times a year by the Duke Medical Alumni Association. to Duke, our new education building — the Mary because of the generosity of our alumni and friends. Issues are available online at Duke Biddle Trent Semans Center — was only an The first dean of the School of Medicine, Wilburt Da- medalumni.duke.edu. idea. We had three fewer departments, and most Your comments, ideas, and letters vison, laid the foundation for the outstanding institu- to the editor are welcome. of the department chairs were different people. tion we are today. He was, like me, a pediatrician. Back then we had only transiently had a Nobel lau- Please contact us at: Dean Davison recognized the importance of excel- DukeMed Alumni News reate on our faculty. Today, we are still celebrating 710 W. Main Street, Suite 200 lence in all of our three missions — clinical care, ed- Robert Lefkowitz’s receipt of the 2012 Nobel Prize Durham, N.C. 27701-3973 ucation and, somewhat ahead of his time, research. 919-385-3100 in Chemistry. He pioneered the idea of compressing the preclinical e-mail: [email protected] Indeed, the School of Medicine has been through curriculum into one year, although that did not Editor a great deal of change formally become part of Duke education until much Marty Fisher since my arrival, and we later.