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(12) Patent Application Publication (10) Pub. No.: US 2017/0182285 A1 TYLER Et Al US 20170182285A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0182285 A1 TYLER et al. (43) Pub. Date: Jun. 29, 2017 (54) SYSTEMIS AND METHODS FOR on May 18, 2015, now Pat. No. 9,517,351, said TRANSIDERMAL ELECTRICAL application No. 15/264.224 is a continuation-in-part STMULATION TO IMPROVE SLEEP of application No. 15/169,445, filed on May 31, 2016. (60) Provisional application No. 62/308.845, filed on Mar. (71) Applicants: William J. TYLER, Newton, MA 15, 2016, provisional application No. 62/100,004, (US); Alyssa M. BOASSO, Brookline, filed on Jan. 5, 2015, provisional application No. MA (US); Hailey M. MORTIMORE, 61/729,851, filed on Nov. 26, 2012, provisional ap Boston, MA (US); Rhonda S. SILVA, plication No. 61/765,795, filed on Feb. 17, 2013, Boston, MA (US): Sumon K. PAL, provisional application No. 61/767.945, filed on Feb. Boston, MA (US); Jonathan 22, 2013, provisional application No. 61/770,479, CHARLESWORTH, Menlo Park, CA filed on Feb. 28, 2013, provisional application No. (US); Linh M. AVEN, Boston, MA 61/841.308, filed on Jun. 29, 2013, provisional appli (US) cation No. 61/845,845, filed on Jul. 12, 2013, provi (72) Inventors: William J. TYLER, Newton, MA sional application No. 61/875.424, filed on Sep. 9, (US); Alyssa M. BOASSO, Brookline, 2013, provisional application No. 61/900,880, filed MA (US); Hailey M. MORTIMORE, on Nov. 6, 2013, provisional application No. 61/875, Boston, MA (US); Rhonda S. SILVA, 891, filed on Sep. 10, 2013, provisional application Boston, MA (US): Sumon K. PAL, No. 61/888,910, filed on Oct. 9, 2013, provisional Boston, MA (US); Jonathan application No. 61/907.394, filed on Nov. 22, 2013, CHARLESWORTH, Menlo Park, CA provisional application No. 62/076,459, filed on Nov. (US); Linh M. AVEN, Boston, MA (Continued) (US) Publication Classification (21) Appl. No.: 15/460,138 (51) Int. C. A6M 2L/02 (2006.01) (22) Filed: Mar. 15, 2017 A61N L/36 (2006.01) A61N L/04 (2006.01) Related U.S. Application Data (52) U.S. C. (63) Continuation-in-part of application No. PCT/ CPC ........... A61M 21/02 (2013.01); A61N I/0456 US2016/012128, filed on Jan. 5, 2016, Continuation (2013.01); A61N I/36025 (2013.01); A61M in-part of application No. 15/264.224, filed on Sep. 2021/0072 (2013.01) 13, 2016, which is a continuation-in-part of applica tion No. 14/558,604, filed on Dec. 2, 2014, now Pat. (57) ABSTRACT No. 9,440,070, which is a continuation-in-part of Methods and apparatuses for improving sleep by transder application No. 14/091,121, filed on Nov. 26, 2013, mal electrical stimulation (TES). In general, described now Pat. No. 8,903,494, said application No. 15/264, herein are methods for applying TES to a subject, and 224 is a continuation-in-part of application No. particularly the Subjects head (e.g., temple/forehead region) 15/170,878, filed on Jun. 1, 2016, said application No. and/or neck with an TES waveform adapted to improve 15/264.224 is a continuation-in-part of application sleep, including reducing sleep onset (falling to sleep) more No. 14/715,470, filed on May 18, 2015, now Pat. No. quickly and/or lengthening the duration of sleep. TES wave 9,474,891, said application No. 15/264.224 is a con form(s) particularly well Suited to enhancing sleep are also tinuation-in-part of application No. 14/715,476, filed described herein. US 2017/O182285 A1 Page 2 Related U.S. Application Data No. 62/099.960, filed on Jan. 5, 2015, provisional application No. 62/100,022, filed on Jan. 5, 2015, 6, 2014, provisional application No. 62/169,522, filed provisional application No. 61/994,860, filed on May on Jun. 1, 2015, provisional application No. 62/169, 17, 2014, provisional application No. 62/100,029. 523, filed on Jun. 1, 2015, provisional application No. filed on Jan. 5, 2015, provisional application No. 62/170,111, filed on Jun. 2, 2015, provisional appli 62/168,615, filed on May 29, 2015, provisional appli cation No. 62/268,084, filed on Dec. 16, 2015, pro cation No. 62/190,211, filed on Jul. 8, 2015, provi visional application No. 62/002.910, filed on May 25, sional application No. 62/200.256, filed on Aug. 3, 2014, provisional application No. 627076,459, filed 2015, provisional application No. 62/213,949, filed on Nov. 6, 2014, provisional application No. 62/075, on Sep. 3, 2015, provisional application No. 62/099, 896, filed on Nov. 6, 2014, provisional application 950, filed on Jan. 5, 2015. Patent Application Publication Jun. 29, 2017. Sheet 1 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017 Sheet 2 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017 Sheet 3 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017 Sheet 4 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017 Sheet 5 of 31 US 2017/0182285 A1 s S -- ws y s s -3.ya 3. s S Patent Application Publication Jun. 29, 2017. Sheet 6 of 31 US 2017/0182285 A1 ~~~--~~~~009 Patent Application Publication Jun. 29, 2017 Sheet 7 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017. Sheet 8 of 31 US 2017/0182285 A1 JosseoOldouo||A. Patent Application Publication Jun. 29, 2017. Sheet 9 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017. Sheet 10 of 31 US 2017/0182285 A1 Ápoquo uoffssesSELque?S Patent Application Publication Jun. 29, 2017. Sheet 11 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017. Sheet 12 of 31 US 2017/0182285 A1 VH N (N Xepu AllenO deeS 6 indS))) Patent Application Publication Jun. 29, 2017. Sheet 13 of 31 US 2017/0182285 A1 n c O t s CD SS - odds no odd Sfond O t O Senu WI t CD 1. <C N v- O E O o ve (5 s Senu W Patent Application Publication Jun. 29, 2017. Sheet 14 of 31 US 2017/0182285 A1 s i. Patent Application Publication US 2017/0182285 A1 Patent Application Publication US 2017/0182285 A1 Patent Application Publication US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017. Sheet 18 of 31 US 2017/0182285 A1 |81||II |z 00011i000II Patent Application Publication Jun. 29, 2017. Sheet 19 of 31 US 2017/0182285 A1 - - - - - - - - - No.tNo.ti *|69|09 Patent Application Publication Jun. 29, 2017. Sheet 20 of 31 US 2017/0182285 A1 {}{}99 EBE-E-LE I ætur;puq Patent Application Publication Jun. 29, 2017. Sheet 21 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017. Sheet 22 of 31 SÁBC]uue?S/NEL! Ilueuuedx=W E Patent Application Publication Jun. 29, 2017. Sheet 23 of 31 US 2017/0182285 A1 s f . s t s ::2: k 3. a jogs full.JON o val w CD O L - E e site se *s 2 SS' 3. : E s s: 2: gx JOJS Buju Joy, -i. OS SSC Patent Application Publication Jun. 29, 2017. Sheet 24 of 31 US 2017/0182285 A1 SWNIWCH SSWOI N3H.I. (CIS)W BU?æse? (CIS)W (£9*T)Z6'E. (68’I)88'?, (£8'O)EZZ (ZZIO)IET (gººg)ZO’? (IZCZ)OL’E (96°9)00°0'L SSðUI?SAVAO.ICI Patent Application Publication Jun. 29, 2017. Sheet 25 of 31 US 2017/0182285 A1 dno.19QUIætu?ea.II,NGHJ, nouÐnuauInea.IJ.Uue?S Patent Application Publication Jun. 29, 2017. Sheet 26 of 31 US 2017/0182285 A1 2. f k k 3C. ae I 2 g :w : -ws re s CC euleSeguo effuelo 9. : (autasequoy afuelp 9%) (Nr N 3.03S SSWO O CD LL r e 9 o 8 3 s E o f H s is g g g is e s : s is 3 (eueseq Log efuelo,,) (euase Luol efieu o A) 80S SSy 9.SSSW Patent Application Publication Jun. 29, 2017. Sheet 27 of 31 US 2017/0182285 A1 2. H f E C (O O w CN N "e se se we (y) (N O L 2. l - c L - > O C (V) C CY (...) r s CO CO 3 (%) JewOde Wilee Jun. 29, 2017. Sheet 28 of 31 US 2017/0182285 A1 Patent Application Publication Jun. 29, 2017. Sheet 30 of 31 US 2017/0182285 A1 Fi N. Carrets zang$ saauan Sy su pue3sy Patent Application Publication Jun. 29, 2017. Sheet 31 of 31 US 2017/0182285 A1 : i. 3. 2 N w t euese Luoy effuel Oueole f US 2017/0182285 A1 Jun. 29, 2017 SYSTEMIS AND METHODS FOR TRANSCRANIAL ELECTRICAL STIMULATION SYS TRANSIDERMAL ELECTRICAL TEMS AND METHODS, filed Oct. 9, 2013: U.S. Provi STIMULATION TO IMPROVE SLEEP sional Patent Application No. 61/907.394, titled “TRAN SCRANIAL ELECTRICAL STIMULATION SYSTEMS CROSS REFERENCE TO RELATED AND METHODS, filed Nov. 22, 2013. Each of these APPLICATIONS applications is herein incorporated by reference in its 0001. This patent application claims priority to U.S. entirety. Provisional Patent Application No. 62/308,845, titled 0004 U.S. patent application Ser. No. 14/558,604 also TRANSDERMAL ELECTRICAL NEUROMODULA claims the benefit of U.S. Provisional Patent Application No. TION OF THE TRIGEMINAL SENSORY NUCLEAR 62/076,459, titled “CANTILEVER ELECTRODES FOR COMPLEX IMPROVES SLEEP QUALITY AND TRANSDERMAL AND TRANSCRANIAL STIMULA MOOD,” filed Mar. 15, 2016, which is herein incorporated TION,” filed Nov. 6, 2014, which is herein incorporated by by reference in its entirety.
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