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Canine Genetic Mutations to the Multi Drug Resistance Gene (MDR1)
Research & Development Canine Genetic Mutations to the Multi Drug Resistance Gene (MDR1) Background vincristine, vinblastine (anticancer agents) acepromazine More than 100 years ago, research showed that certain (tranquiliser) butorphanol (pain control), erythromycin chemical dyes injected into the peripheral circulation (antibiotics), and emodepside (dewormer). infiltrated most organs, with one exception – the brain. This led to the well-known concept of a blood-brain barrier. There are additional drugs that may also cause Research in the early 1960s showed that the basis of the problems including morphine, cyclosporin, digoxin, blood-brain barrier is the specialised endothelial cells of rifampin, ondansetron, domperidone, paclitaxel, brain capillaries. A number of active transport systems mitoxantrone, etoposide, rifampicin and quinidine. exist that selectively regulate both influx and efflux of compounds across brain capillary endothelial cells. The Many of the problematic drugs are very commonly most important drug-efflux system of the blood-brain prescribed. For example, ivermectin is found in canine barrier identified to date is P-glycoprotein, P-gp. heartworm prevention, worming and anti-mange medications. Additionally, the drug is used to prevent The product of the mdr1 (multidrug resistance) gene is parasites in horses and livestock. While the amount P-glycoprotein, a cell-surface protein that functions as a of ivermectin found in a normal dose of heartworm drug-efflux pump. P-glycoprotein was first identified over prevention medication should not be a concern, larger 20 years ago in chemotherapeutic drug-resistant tumour doses of ivermectin, such as the amount used to control cells, and is now known to be a major cause of multidrug mange or for worming, can have serious effects. -
Crufts 2019 Order Form
LABOKLIN @ CRUFTS 2019 TH TH 7 – 10 March 10% Discount* on all DNA tests submitted at Crufts Dear Breeder / Dog Owner, We are pleased to inform you that LABOKLIN will be at Crufts 2019 and we look forward to seeing you there. Our stand is located in Hall 3 opposite the restaurant, it is stand number 3-7a. 10% Discount on all DNA tests submitted at Crufts ! and this includes our new Breed Specific DNA Bundles. You can submit a sample at Crufts in the following ways: 1) Bring your dog to our stand 3-7a, we will take a DNA sample for your genetic test, all you need to do is complete this order form and pay the fees. Or, 2) If you don't want to wait in the queue, you can prepare your sample in advance and bring it together with this order form with you to our stand, you can order a free DNA testing kit on our website www.laboklin.co.uk. We will send you a testing kit which also contains instructions on how to take DNA sample. Prepare your sample up to a week before your planned visit, just hand the sample to us. 3) If you prefer to use blood for your test, ask your vet to collect 0.5-1 ml of whole blood in EDTA blood tube, bring it together with the completed order form to the show, just hand it to us. Please note we will only accept Cash, Cheques or Postal Orders at the show. If you wish to pay by card, you can complete the card payment section. -
The Shetland Sheepdog (Sheltie)
THE SHETLAND SHEEPDOG (SHELTIE) UNIQUE ORIGIN: Shelties, as they are affectionately called, hail from the rugged Shetland Islands, which lie between Scotland and Norway. These islands are also home to the Shetland Ponies and Shetland Sheep, all diminutive animals. Shetland Sheepdogs were bred by crossing the Border Collie, the rough Collie, and various other breeds. By 1700, the Sheltie was completely developed. They were developed to herd the sheep flocks of the Shetland Islands, and also to protect them from birds of prey, such as eagles. You can still catch Shelties chasing birds. Today, the Sheltie is one of the most popular dogs in America. PERSONALITY: Shetland Sheepdogs are hardy, loyal, obedient, gentle, loving, and extremely trainable. They are incredibly intelligent, ranking 6th out of 132 different dog breeds according to Dr. Stanley Coren, an animal intelligence expert, which means that they understand new commands with less than 5 repetitions and obey first commands 95% of the time. This dog needs a job with plenty of exercise or else they might invent their own entertainment. They are also very in tune to their owner’s thoughts and moods. Shelties are devoted family pets and are especially fond of children. They love attention and love to learn. They thrive in an environment where they’re given playtime, training, and loving attention. They will love you in return tenfold. APPEARANCE: Shelties usually weigh between 12 to 18 pounds and stand approximately 12 to 15 inches tall. Their build is trim with a light frame. They are incredibly beautiful dogs and are known for their beautiful coat. -
Baskerville Ultra Muzzle Breed Guide. Sizes Are Available in 1 - 6 and Are for Typical Adult Dogs & Bitches
Baskerville Ultra Muzzle Breed Guide. Sizes are available in 1 - 6 and are for typical adult dogs & bitches. Juveniles may need a size smaller. ‡ = not recommended. The number next to the breeds below is the recommended size. Boston Terrier ‡ Bulldog ‡ King Charles Spaniel ‡ Lhasa Apso ‡ Pekingese ‡ Pug ‡ St Bernard ‡ Shih Tzu ‡ Afghan Hound 5 Airedale 5 Alaskan Malamute 5 American Cocker 2 American Staffordshire 6 Australian Cattle Dog 3 Australian Shepherd 3 Basenji 2 Basset Hound 5 Beagle 3 Bearded Collie 3 Bedlington Terrier 2 Belgian Shepherd 5 Bernese MD 5 Bichon Frisé 1 Border Collie 3 Border Terrier 2 Borzoi 5 Bouvier 6 Boxer 6 Briard 5 Brittany Spaniel 5 Buhund 2 Bull Mastiff 6 Bull Terrier 5 Cairn Terrier 2 Cavalier Spaniel 2 Chow Chow 5 Chesapeake Bay Retriever 5 Cocker (English) 3 Corgi 3 Dachshund Miniature 1 Dachshund Standard 1 Dalmatian 4 Dobermann 5 Elkhound 4 English Setter 5 Flat Coated Retriever 5 Foxhound 5 Fox Terrier 2 German Shepherd 5 Golden Retriever 5 Gordon Setter 5 Great Dane 6 Greyhound 5 Hungarian Vizsla 3 Irish Setter 5 Irish Water Spaniel 3 Irish Wolfhound 6 Jack Russell 2 Japanese Akita 6 Keeshond 3 Kerry Blue Terrier 4 Labrador Retriever 5 Lakeland Terrier 2 Lurcher 5 Maltese Terrier 1 Maremma Sheepdog 5 Mastiff 6 Munsterlander 5 Newfoundland 6 Norfolk/Norwich Terrier 1 Old English Sheepdog 5 Papillon N/A Pharaoh Hound 5 Pit Bull 6 Pointers 4 Poodle Toy 1 Poodle Standard 3 Pyrenean MD 6 Ridgeback 5 Rottweiler 6 Rough Collie 3 Saluki 3 Samoyed 4 Schnauzer Miniature 2 Schnauzer 3 Schnauzer Giant 6 Scottish Terrier 3 Sheltie 2 Shiba Inu 2 Siberian Husky 5 Soft Coated Wheaten 4 Springer Spaniel 4 Staff Bull Terrier 6 Weimaraner 5 Welsh Terrier 3 West Highland White 2 Whippet 2 Yorkshire Terrier 1 . -
AKC Meet the Breed 03
traditional white collar, chest, legs, feet, tail tip and children. Even when not raised with children, the THE COLLIE CLUB OF AMERICA PRESENTS sometimes white facial markings, called a blaze. Collie can be charming, playful and protective with most well behaved kids. Stories have abounded for The Collie COLLIE SIZE: years of children guarded and protected by the fam- ily Collie. The Collie is a medium-sized dog, with females COLLIE ORIGINS: ranging from 22" to 24" and males ranging from COLLIE CARE: The Collie was used extensively as a herding dog 24" to 26" at maturity. Weights can range from 50 and hailed from the highlands of Scotland and to 70 pounds. A common misconception is that the Collie needs Northern England. The true popularity of the daily brushing or frequent bathing. The amount breed came about during the 1860’s when Queen COLLIE LONGEVITY: of coat care is dependent upon the amount of coat Victoria visited the Scottish Highlands and fell in a dog may have and the time of year. Rough Col- love with the breed. From that point on Collies Typically Collies live 10 to 14 years, with the me- lies in full coat should be brushed once a week or became very fashionable. The Collie’s character dian age being 12, although some have gone well every two weeks. A dog that is out of coat or in has been further romanticized and portrayed as the into their 15th or 16th year. summer coat is going to need less grooming. ideal family companion by such authors as Albert Spayed females and males shed once a year. -
Tuesday, July 30
RALLY ADVANCED Tuesday, July 30, 2019 1ST Lauren Hitt Franklin Lily All American 2ND Emily Wentland Defiance Gunner Mini American Shepherd 3RD Bailey Bowen Williams Luigi Golden Retriever 4TH Savannah Henderson Clinton Brownie Australian Shepherd Mix Cavalier King Charles 5TH Shelby Firth Portage Tyson Spaniel 6TH Caitlyn Mahaffey Brown Clover Corgi 7TH Sydney Wilson Knox Bamboo Australian Cattle Dog RALLY EXCELLENT Tuesday, July 30, 2019 1ST Emily Burrier Coshocton Sophie Shetland Sheepdog 2ND Allison Sanders Clark Gracie Labrador Retriever 3RD Bailey Bowen Williams Peach Golden Retriever 4TH Morgan Mahaffey Brown Astara Labrador Retriever RALLY INTERMEDIATE A Tuesday, July 30, 2019 1ST Danica Henderson Clinton Skipper Shetland Sheepdog 2ND Emmy Hawkins Highland Duke Mini American Shepherd 3RD Katelyn Kauscher Warren Midnight Basset Hound/Lab Mix 4TH Sarah Decker Licking Mia Golden Retriever 5TH Jenna Turner Clermont Drop Min Pin/Dachshund Mix 6TH Danielle Mascioni Champaign Ranger Black Mouth Cur 7TH Anthony Cramer Hancock Knight Labrador Retriever 8TH Anthony Cramer Hancock Cub Boxer 9TH Morgan Heitkamp Darke Rocky Miniature Poodle 10TH Aleksandra Thomas Warren Nigel Yorkshire Terrier 11TH Elijah Voorhees Franklin Gray Shetland Sheepdog 12TH Emily Holmes Medina Ricki Bobbi Rhodesian Ridgeback 13TH Jenna Turner Clermont Drizzle Min Pin/Chihuahua Mix 14TH Naomi Hathaway Darke Hoolihan Hound Mix 15TH Molly Roosa Portage Duke Poodle Mix RALLY INTERMEDIATE B Tuesday, July 30, 2019 1ST Holley Cooperrider Licking Luke Golden Retriever 2ND -
Site Hounds Heights Greater Than Or Equal To
AKC Fast CAT Placements SOTC Sunday, May 23, 2021 Sunday #1 #2 Place- Best Between Entry # Handler Name Call Name Breed MPH ments the Two Times Site Hounds 1 115 Dawn Strawn Creedence Whippet/Windsprite 7.01 29.16 2 141 Jeannine McKnight Abby Windsprite 7.16 28.59 3 142 Jeannine McKnight Ava Greyhound 7.33 27.91 4 128 Jean D Martin Zaki Saluki 7.43 27.54 5 33 Brooke Mawery Mae Rhodesian Ridgeback 7.91 25.86 6 154 Katie Besemer Emmy Basenji 8.11 25.23 7 153 Katie Besemer Opal Basenji 8.34 24.54 Turtle 13 Pamela Zygmunt Zucaro Pharaoh Hound 8.93 22.91 Heights Greater Than or Equal to 18" 1 112 Dawn Strawn Hoax Dutch Shepherd 7.13 28.68 2 36 Tammy Rogers BANNER REDBONE COONHOUND 7.70 26.56 3 94 Diane Betelak Danny K poodle 7.73 26.48 4 1 Terri Botsford Miranda All American 7.82 26.17 5 12 Naneese Bonnell Scout Australian Shepherd 7.89 25.94 6 22 Karen Hensley Allie Golden Retriever 7.90 25.88 7 37 Brooke Mawery Nala Rhodesian Ridgeback 7.95 25.72 8 3 Karen Vanderburgh Nicki ESS 7.98 25.62 9 44 Jodi Lepik Rayna All American Dog 7.99 25.61 10 176 Kathy McCloskey Dancer Golden Retriever 7.99 25.61 11 35 Brooke Mawery Newton All American 8.00 25.56 12 69 Jessica Sielawa Ernie Brittany 8.06 25.38 13 111 Kathleen OBrien Charlotte Afghan Hound 8.11 25.23 14 159 Danielle Knobel Persephone All American 8.11 25.21 15 199 Linda Matthews Peaches Weimaraner 8.17 25.02 16 145 Morgan Lynd Smack Australian Shepherd 8.19 24.97 17 14 Pamela Hottois Moon Pie Australian Shepherd 8.32 24.59 18 6 Thomas Canino Lincoln Labrador Retriever 8.40 24.36 19 40 Anne Allison DUCK LABRADOR RETRIEVER 8.40 24.36 20 86 Hailey Menzi Asher Standard Poodle 8.41 24.33 21 200 Linda Matthews River Weimaraner 8.43 24.27 22 10 Jennifer Veator Indy Doberman Pinscher 8.48 24.11 23 196 Dottie Hamblin Ruby Bearded Collie 8.49 24.08 24 9 Susan A Morse Jam Belgian Malinois 8.51 24.05 25 63 MacKenzie Waro Zulu Doberman Pinscher 8.57 23.86 26 30 Amanda Brown Dare English Springer Spa 8.92 22.93 27 158 Danielle Knobel Druid Standard Poodle 8.98 22.78 28 201 Denise Hull Essie Great Pyrenees 9.32 21.95 29 76 Martha j. -
Domestic Dog Breeding Has Been Practiced for Centuries Across the a History of Dog Breeding Entire Globe
ANCESTRY GREY WOLF TAYMYR WOLF OF THE DOMESTIC DOG: Domestic dog breeding has been practiced for centuries across the A history of dog breeding entire globe. Ancestor wolves, primarily the Grey Wolf and Taymyr Wolf, evolved, migrated, and bred into local breeds specific to areas from ancient wolves to of certain countries. Local breeds, differentiated by the process of evolution an migration with little human intervention, bred into basal present pedigrees breeds. Humans then began to focus these breeds into specified BREED Basal breed, no further breeding Relation by selective Relation by selective BREED Basal breed, additional breeding pedigrees, and over time, became the modern breeds you see Direct Relation breeding breeding through BREED Alive migration BREED Subsequent breed, no further breeding Additional Relation BREED Extinct Relation by Migration BREED Subsequent breed, additional breeding around the world today. This ancestral tree charts the structure from wolf to modern breeds showing overlapping connections between Asia Australia Africa Eurasia Europe North America Central/ South Source: www.pbs.org America evolution, wolf migration, and peoples’ migration. WOLVES & CANIDS ANCIENT BREEDS BASAL BREEDS MODERN BREEDS Predate history 3000-1000 BC 1-1900 AD 1901-PRESENT S G O D N A I L A R T S U A L KELPIE Source: sciencemag.org A C Many iterations of dingo-type dogs have been found in the aborigine cave paintings of Australia. However, many O of the uniquely Australian breeds were created by the L migration of European dogs by way of their owners. STUMPY TAIL CATTLE DOG Because of this, many Australian dogs are more closely related to European breeds than any original Australian breeds. -
Collie Club of Colorado
ENTRIES CLOSE WEDNESDAY 8:00 P.M. (MDT), October 10, 2018 AT SHOW SECRETARY'S OFFICE After which time entries cannot be accepted, canceled, altered or substituted except as provided for in Chapter 11, Section 6 of the AKC Dog Show Rules 135th & 136th Independent Specialty Shows (2) & Junior Showmanship* (1) (UNBENCHED) Event #2018095507 & #2018095510 AKC NATIONAL OWNER-HANDLED SERIES Friday show only *Junior Showmanship on Saturday only Collie Club of Colorado (Licensed by the American Kennel Club) Island Grove Regional Park 501 N 14th Ave Entrance to Park for Dog Events is on 11th Ave Greeley, Colorado FRIDAY, October 26, and SATURDAY, October 27, 2018 SHOW SITE HOURS 6:00 AM - 10:00 PM THIS SHOW WILL BE HELD INDOORS SHOW SECRETARY – Sue Scott Champion Dog Events 28485 Mid Jones Road Calhan, CO. 80808 phone - (719) 338-0065 e-mail – [email protected] www.championdogevents.com CERTIFICATION Permission has been granted by the American Kennel Club for the holding of this event under the American Kennel Club rules and regulations. GINA M DINARDO, Executive Secretary pg. 1 OFFICERS of the Collie Club of Colorado Lynn Brown…………………………………………..………………..….……………..President Shelley Bergstraser………………………………………..……….…………………..Vice President Cindy Cornelius….................................................................................................Treasurer Kathy Mesler…………………………………………………………………………….Recording Secretary Chuck Crone ……………………………………..…………….….………………...…Corresponding Secretary Board of Directors - April Fingerlos Donine Schwartz SHOW -
RCBC Presentation
The ROUGH COLLIE BREED COUNCIL established 1966 www.roughcolliebreedcouncil.org.uk UNDERSTANDING THE RELEVANCE OF WHITE-FACTOR IN THE COLLIE o understand the relevance of a Rough Collie’s colour and markings one must understand its origin and original purpose. In common with its close cousins the Smooth, Bearded, Tand Border Collies plus Shetland Sheepdog together with a number of North American and Australian herding types, the Rough Collie can trace its ancestry back to the General British Stock Dog which had been carefully bred by stockmen, flock-masters, and drovers for more than four hundred years prior to the advent of dog shows in the mid 18th Century. As practical country men living hard and demanding lives on very limited incomes their need was for a practical, hardy, lithe, athletic and intelligent dog capable of assisting them in their adduces task. To this end they required an animal that would contrast with the sheep and cattle which have traditionally grazed the upland areas of the British Isles, yet still be visible in poor lighting conditions, thus explaining why all British herding breeds sport coloured bodies with white areas, particularly on neck, head, chest and tail. Therefore, without knowing anything about genetics, early breeders selected for, what we now term, White-Factor animals and the predominantly white animal would usually be culled at birth although occasionally one would be raised for work around the farm-yard, or with young lambs. hen the Collie first entered the show ring in 1860, they were, like all breeds, judged by Wgeneral stockmen who invariably placed a flashily marked specimen above their plainer cousins, and as exhibitors will always veer to the type which attracts a judge’s attention so the show Collie has traditionally possessed flashy white markings. -
Collie (Rough)
FEDERATION CYNOLOGIQUE INTERNATIONALE (AISBL) SECRETARIAT GENERAL: 13, Place Albert 1er B – 6530 Thuin (Belgique) ______________________________________________________________________________ _______________________________________________________________ 22.11.2012/EN _______________________________________________________________ FCI-Standard N° 156 COLLIE (ROUGH) ©M. Davidson, illustr. NKU Picture Library 2 ORIGIN: Great Britain. DATE OF PUBLICATION OF THE OFFICIAL VALID STANDARD: 08.10.2012. UTILIZATION: Sheepdog. FCI-CLASSIFICATION: Group 1 Sheepdogs and Cattle Dogs (except Swiss Cattle Dogs). Section 1 Sheepdogs. Without working trial. BRIEF HISTORICAL SUMMARY: The rough and the smooth Collie is the same with the exception of coat length. The breed is thought to have evolved from dogs brought originally to Scotland by the Romans which then mated with native types. Purists may point to subtle differences which have appeared as individual breeders selected stock for future breeding, but the fact remains that the two breeds derived very recently from the same stock and, in truth, share lines which can be found in common to this day. The Rough Collie is the somewhat refined version of the original working collie of the Scottish shepherd, from which it has been selected over at least a hundred years. Many of the dogs can still perform satisfactorily at work, offered the chance. The basic message is that for all his beauty, the Collie is a worker. GENERAL APPEARANCE: Appears as a dog of great beauty, standing with impassive dignity, with no part out of proportion to whole. Physical structure on lines of strength and activity, free from cloddiness and with no trace of coarseness. Expression most important. In considering relative values it is obtained by perfect balance and combination of skull and foreface, size, shape, colour and placement of eyes, correct position and carriage of ears. -
Dogs of Scotland
DOGSDOGS OF OF SCOTLAND There are 13 breeds of dogs which have their origins in or along the borders of Scotland or among the islands near its shores. All the dogs were developed with a specific job to do. The work included 1) gathering and driving a flock or herd of farm animals, 2) hunting and retrieving game, or 3) protecting livestock or crops from predators. In addition to their original purposes, these dogs are wonderful companions and are very popular in the United States and Scotland as elsewhere in the world. The breeds are the Bearded Collie, Border Collie, Border Terrier, Cairn Terrier, Collie (rough and smooth varieties), Dandie Dinmont Terrier, Golden Retriever, Gordon Setter, Scottish Deerhound, Scottish Terrier, Shetland Sheepdog, Skye Terrier, and West Highland White Terrier. Herding Dogs Herding Dogs Herding Dogs, traditionally are used in Scotland to gather, drive, and protect domestic farm animals. Collie Rough (left below) and Smooth Border Collie (2 colors) Bearded Collie Shetland Sheepdog The Bearded Collie is possibly Scotland’s oldest breed of dog and is a gentle, happy dog devoted to its family. A Beardie will have a long, shaggy coat that may be black, gray, brown, or fawn with or without areas of white. With the fur on its head, one might think it would have trouble seeing. However, when the Beardie moves the fur blows backward allowing the dog to see very well. The Border Collie originated in the border country between Scotland and England. You can see a demonstration today at the Virginia Scottish Games of how a BC works with its shepherd to contain and move sheep.