On-line Table 1: Correlation of PS score and expression levels of with “positive regulation of angiogenesis” ID Reporter_ID P-value Estimate Lower Upper AAMP A_23_P56528 0.2128 0.31 Ϫ0.18 0.68 AAMP A_23_P56529 0.2044 0.31 Ϫ0.18 0.68 AGGF1 A_23_P250551 0.2960 0.26 Ϫ0.23 0.65 AGGF1 A_23_P250554 0.5046 0.17 Ϫ0.32 0.59 AGGF1 A_23_P250559 0.1138 0.39 Ϫ0.10 0.72 AGGF1 A_23_P41969 0.2394 Ϫ0.29 Ϫ0.67 0.20 AGGF1 A_23_P41970 0.2399 Ϫ0.29 Ϫ0.67 0.20 AGGF1 A_24_P256513 0.7364 Ϫ0.09 Ϫ0.53 0.40 AGGF1 A_24_P256520 0.3776 0.22 Ϫ0.27 0.62 ANGPT2 A_23_P60079 0.5634 0.15 Ϫ0.34 0.57 ANGPT2 A_24_P367900 0.6282 Ϫ0.12 Ϫ0.56 0.37 ANGPT2 A_24_P932435 0.9000 Ϫ0.03 Ϫ0.49 0.44 ANGPT4 A_23_P68511 0.4758 Ϫ0.18 Ϫ0.60 0.31 ANGPTL3 A_23_P160261 0.6575 0.11 Ϫ0.37 0.55 ANGPTL3 A_23_P160262 0.3313 0.24 Ϫ0.25 0.64 ANGPTL4 A_23_P159325 0.7800 Ϫ0.07 Ϫ0.52 0.41 ANGPTL4 A_23_P159328 0.7506 Ϫ0.08 Ϫ0.53 0.40 ANGPTL4 A_23_P159330 0.7289 Ϫ0.09 Ϫ0.53 0.40 ANGPTL4 A_23_P170716 0.8881 Ϫ0.04 Ϫ0.49 0.44 ANGPTL4 NM_139314_1_1810 0.7960 Ϫ0.07 Ϫ0.52 0.41 ANXA3 A_23_P121712 0.8941 Ϫ0.03 Ϫ0.49 0.44 ANXA3 A_23_P121716 0.6471 Ϫ0.12 Ϫ0.55 0.37 AQP1 A_23_P19894 0.1831 Ϫ0.33 Ϫ0.69 0.16 AQP1†† A_23_P19895 0.0997 Ϫ0.40 Ϫ0.73 0.08 AQP1†† A_23_P372834 0.0984 Ϫ0.40 Ϫ0.73 0.08 AQP1†† BC022486_1_2437 0.0887 Ϫ0.41 Ϫ0.74 0.07 BTG1 A_23_P87560 0.4756 0.18 Ϫ0.31 0.60 BTG1 A_23_P87563 0.6033 0.13 Ϫ0.36 0.56 BTG1 A_23_P87564 0.6487 0.12 Ϫ0.37 0.55 BTG1 A_32_P225865 0.6402 Ϫ0.12 Ϫ0.55 0.37 BTG1 A_32_P225870 0.9000 0.03 Ϫ0.44 0.49 C3 A_23_P101400 0.1521 Ϫ0.35 Ϫ0.70 0.14 C3 A_23_P101405 0.1977 Ϫ0.32 Ϫ0.68 0.17 C3 A_23_P101407 0.1689 Ϫ0.34 Ϫ0.70 0.15 C3†† A_32_P123697 0.0953 Ϫ0.41 Ϫ0.73 0.08 C3 A_32_P123701 0.1397 Ϫ0.36 Ϫ0.71 0.13 C3 NM_000064_1_4175 0.3249 Ϫ0.25 Ϫ0.64 0.25 C3AR1 A_23_P2431 0.2987 0.26 Ϫ0.24 0.65 C3AR1 A_23_P2432 0.2487 0.29 Ϫ0.21 0.66 C5 A_23_P71855 0.7276 Ϫ0.09 Ϫ0.53 0.39 C5 A_23_P71856 0.5116 Ϫ0.17 Ϫ0.59 0.33 C5AR1 A_23_P153560 0.5594 Ϫ0.15 Ϫ0.57 0.34 C5AR1 A_23_P153562 0.9181 0.03 Ϫ0.45 0.49 C5AR1 A_23_P303051 0.8891 0.04 Ϫ0.44 0.49 C5AR1 A_23_P303058 0.2704 0.27 Ϫ0.22 0.66 C6 A_23_P92920 0.5691 Ϫ0.14 Ϫ0.57 0.35 C6 A_23_P92925 0.7488 Ϫ0.08 Ϫ0.53 0.40 C6 A_23_P92928 0.6681 Ϫ0.11 Ϫ0.55 0.38 CAMP A_23_P253791 0.5703 Ϫ0.14 Ϫ0.57 0.35 CAMP A_23_P253792 0.5618 Ϫ0.15 Ϫ0.57 0.34 CCL11 A_23_P66627 0.7671 0.08 Ϫ0.41 0.52 CCL11 A_23_P66635 0.9011 Ϫ0.03 Ϫ0.49 0.44 CCL24 A_23_P215491 0.1732 Ϫ0.34 Ϫ0.69 0.16 CCR3 A_23_P250302 0.2650 0.28 Ϫ0.22 0.66 CCR3†† A_24_P367473 0.0155 Ϫ0.56 Ϫ0.81 Ϫ0.13 CCR3 A_24_P367481 0.8566 Ϫ0.05 Ϫ0.50 0.43 CHRNA7 A_23_P163388 0.2967 0.26 Ϫ0.24 0.65 CHRNA7 A_23_P163390 0.2162 0.31 Ϫ0.19 0.68 CX3CL1 A_23_P37724 0.7510 0.08 Ϫ0.40 0.53 CX3CL1 A_23_P37727 0.7527 0.08 Ϫ0.40 0.53 CX3CL1 A_24_P381901 0.6073 0.13 Ϫ0.36 0.56 CX3CL1 A_24_P381906 0.2495 Ϫ0.29 Ϫ0.66 0.21 CX3CL1 A_24_P390490 0.7351 Ϫ0.09 Ϫ0.53 0.40 CX3CL1* A_24_P390495 0.0416 0.48 0.02 0.78 CX3CL1 NM_002996_1_3128 0.7782 0.07 Ϫ0.41 0.52 (Continued)

T10 ͉ AJNR ͉͉www.ajnr.org On-line Table 1: Continued Gene ID ReporterϪID P-value Estimate Lower Upper CX3CL1 NM_002996_1_3198 0.7539 0.08 Ϫ0.40 0.53 CX3CL1 Not Measured CX3CL1 Not Measured CYR61 A_23_P46426 0.3799 0.22 Ϫ0.27 0.62 CYR61 A_23_P46429 0.3442 0.24 Ϫ0.26 0.63 CYR61 A_24_P370946 0.2137 0.31 Ϫ0.19 0.68 CYR61 A_32_P58356 0.3826 0.22 Ϫ0.28 0.62 CYR61 A_32_P58361 0.9323 0.02 Ϫ0.45 0.48 CYR61 NM_001554_1_1729 0.3948 0.21 Ϫ0.28 0.62 DDAH1 A_23_P201380 0.4679 0.18 Ϫ0.31 0.60 DDAH1 A_23_P201386 0.4788 0.18 Ϫ0.31 0.60 DDAH1 A_32_P165407 0.5447 Ϫ0.15 Ϫ0.58 0.34 DDAH1 AK098405_1_2813 0.4286 0.20 Ϫ0.30 0.61 ECM1 A_23_P149180 0.3562 0.23 Ϫ0.26 0.63 ECM1 A_23_P160559 0.2868 0.27 Ϫ0.23 0.65 ECM1 A_23_P160563 0.3747 0.22 Ϫ0.27 0.62 ECM1 AK097205_1_2918 0.3538 0.23 Ϫ0.26 0.63 ERAP1 Not Measured EREG A_23_P41344 0.6091 0.13 Ϫ0.36 0.56 EREG A_23_P41347 0.7894 Ϫ0.07 Ϫ0.52 0.41 EREG A_24_P217520 0.4794 Ϫ0.18 Ϫ0.60 0.31 EREG A_24_P217522 0.1895 Ϫ0.32 Ϫ0.69 0.17 EREG NM_001432_1_3866 0.7289 0.09 Ϫ0.40 0.53 ETS1 A_23_P127525 0.4204 0.20 Ϫ0.29 0.61 ETS1 A_23_P329212 0.4304 Ϫ0.20 Ϫ0.61 0.30 ETS1 A_24_P136670 0.2059 0.31 Ϫ0.18 0.68 F3 A_23_P115382 0.4952 0.17 Ϫ0.32 0.59 F3 A_23_P126782 0.1356 0.37 Ϫ0.12 0.71 FGF2 A_23_P155855 0.5326 0.16 Ϫ0.33 0.58 FGF2 A_23_P155857 0.2378 0.29 Ϫ0.20 0.67 FGF2** A_23_P218910 0.0673 0.44 Ϫ0.03 0.75 FGF2 A_23_P218918 0.2350 0.29 Ϫ0.20 0.67 FIGF A_23_P33796 0.5900 0.14 Ϫ0.35 0.57 FIGF A_23_P45185 0.8676 0.04 Ϫ0.43 0.50 GATA2 A_23_P110022 0.2802 Ϫ0.27 Ϫ0.65 0.23 GATA2 A_24_P165998 0.7509 Ϫ0.08 Ϫ0.53 0.40 GATA2 A_24_P166000 0.5529 Ϫ0.15 Ϫ0.58 0.34 GATA4 A_23_P384754 0.1021 0.40 Ϫ0.08 0.73 GATA4* A_23_P384761 0.0288 0.51 0.06 0.79 GATA4 A_23_P82722 0.1023 Ϫ0.40 Ϫ0.73 0.09 HIF1A* A_23_P427158 0.0065 0.62 0.21 0.84 HIF1A* A_24_P56388 0.0141 0.57 0.14 0.82 HIF1A* NM_001530_1_3499 0.0326 0.50 0.05 0.79 HMOX1 A_23_P120883 0.8747 0.04 Ϫ0.43 0.50 HMOX1 A_23_P120884 0.8666 0.04 Ϫ0.43 0.50 HMOX1 NM_002133_1_1231 0.8854 0.04 Ϫ0.44 0.50 IL1A A_23_P72096 0.9863 0.00 Ϫ0.47 0.46 IL1A A_24_P45892 0.9259 Ϫ0.02 Ϫ0.49 0.45 IL1A NM_000575_3_2535 0.9427 Ϫ0.02 Ϫ0.48 0.45 IL1A NM_000575_3_2635 0.8952 Ϫ0.03 Ϫ0.49 0.44 IL1B A_23_P79518 0.5246 Ϫ0.16 Ϫ0.58 0.33 IL1B A_23_P79523 0.3798 Ϫ0.22 Ϫ0.62 0.27 IL1B NM_000576_2_853 0.6247 Ϫ0.12 Ϫ0.56 0.36 ITGB2 A_23_P211180 0.8231 Ϫ0.06 Ϫ0.51 0.42 ITGB2 A_23_P329570 0.8454 0.05 Ϫ0.43 0.50 ITGB2 A_23_P329573 0.7208 Ϫ0.09 Ϫ0.53 0.39 ITGB2 A_23_P430411 0.6832 0.10 Ϫ0.38 0.54 ITGB2 A_23_P430412 0.1094 0.39 Ϫ0.09 0.73 ITGB2 NM_000211_1_1938 0.2183 0.31 Ϫ0.19 0.68 KDR* A_23_P58416 0.0181 0.55 0.11 0.81 KDR* A_23_P58419 0.0387 0.49 0.03 0.78 KDR* A_24_P71973 0.0097 0.59 0.17 0.83 KDR* NM_002253_1_5246 0.0203 0.54 0.10 0.80 KDR* NM_002253_1_5290 0.0435 0.48 0.02 0.77 MMP9 A_23_P40174 0.9893 0.00 Ϫ0.46 0.47 MMP9 A_23_P40175 0.9546 Ϫ0.01 Ϫ0.48 0.46 (Continued)

AJNR Am J Neuroradiol ͉͉www.ajnr.org T11 On-line Table 1: Continued Gene ID ReporterϪID P-value Estimate Lower Upper MMP9 NKI_NM_004994 0.9315 0.02 Ϫ0.45 0.48 MMP9 NM_004994_1_1525 0.3523 0.23 Ϫ0.26 0.63 MMP9 NM_004994_1_1989 0.8489 0.05 Ϫ0.43 0.50 NOS3 A_23_P70849 0.1998 Ϫ0.32 Ϫ0.68 0.18 NOS3 A_23_P70850 0.3311 Ϫ0.24 Ϫ0.64 0.25 PLCG1 A_24_P100049 0.3274 0.24 Ϫ0.25 0.64 RHOB A_23_P51136 0.3519 0.23 Ϫ0.26 0.63 RHOB A_23_P51140 0.3164 0.25 Ϫ0.25 0.64 RHOB NM_004040_1_532 0.3038 0.26 Ϫ0.24 0.65 RUNX1 A_24_P34155 0.3259 0.25 Ϫ0.25 0.64 RUNX1 A_24_P34157 0.3356 0.24 Ϫ0.25 0.64 RUNX1** A_24_P96403 0.0904 0.41 Ϫ0.07 0.74 RUNX1 A_24_P96404 0.1386 0.36 Ϫ0.12 0.71 SERPINE1** A_24_P158089 0.0922 0.41 Ϫ0.07 0.74 SERPINE1** A_32_P10401 0.0905 0.41 Ϫ0.07 0.74 SERPINE1 A_32_P10403 0.1220 0.38 Ϫ0.11 0.72 SERPINE1** NM_000602_1_2134 0.0814 0.42 Ϫ0.06 0.74 SERPINE1** NM_000602_1_2386 0.0963 0.40 Ϫ0.08 0.73 SFRP2 A_23_P81098 0.5277 0.16 Ϫ0.33 0.58 SFRP2 A_23_P81103 0.8409 Ϫ0.05 Ϫ0.51 0.43 SFRP2 A_24_P137501 0.8839 Ϫ0.04 Ϫ0.50 0.44 SFRP2 A_24_P137502 0.8842 Ϫ0.04 Ϫ0.50 0.44 SFRP2 A_24_P934546 0.7585 0.08 Ϫ0.40 0.53 SFRP2 AK093922_1_1403 0.8139 Ϫ0.06 Ϫ0.51 0.42 SPHK1 A_23_P38104 0.4667 Ϫ0.18 Ϫ0.60 0.31 SPHK1 A_23_P38106 0.7139 Ϫ0.09 Ϫ0.54 0.39 TBXA2R A_23_P355471 0.7431 0.08 Ϫ0.40 0.53 TBXA2R A_23_P90355 0.2240 0.30 Ϫ0.19 0.67 TBXA2R A_23_P90357 0.7364 0.09 Ϫ0.40 0.53 TEK A_23_P216822 0.2013 0.32 Ϫ0.18 0.68 TEK** A_23_P374694 0.0567 0.46 Ϫ0.01 0.76 TEK** A_23_P374695 0.0550 0.46 Ϫ0.01 0.76 TEK** A_23_P374699 0.0633 0.45 Ϫ0.03 0.76 THBS1 A_23_P206210 0.4339 0.20 Ϫ0.30 0.61 THBS1 A_23_P206212 0.3951 0.21 Ϫ0.28 0.62 THBS1 A_32_P17173 0.9971 0.00 Ϫ0.47 0.47 THBS1 A_32_P17182 0.9151 0.03 Ϫ0.45 0.49 TNFRSF1A A_23_P139715 0.1498 0.35 Ϫ0.14 0.70 TNFRSF1A A_23_P139716 0.1501 0.35 Ϫ0.14 0.70 TNFRSF1A A_23_P139722 0.2849 0.27 Ϫ0.23 0.65 TNFRSF1A* A_24_P364359 0.0239 0.53 0.08 0.80 TNFRSF1A* A_24_P364363 0.0324 0.51 0.05 0.79 TNFRSF1A NM_001065_2_2074 0.1391 0.36 Ϫ0.13 0.71 TNFSF12 A_23_P141224 0.2866 Ϫ0.27 Ϫ0.65 0.23 TNFSF12 A_23_P141233 0.3778 0.22 Ϫ0.27 0.62 TNFSF12 A_24_P245298 0.5418 Ϫ0.15 Ϫ0.58 0.34 UTS2 A_23_P63340 0.6152 Ϫ0.13 Ϫ0.56 0.36 UTS2 A_23_P63343 0.6179 Ϫ0.13 Ϫ0.56 0.36 UTS2 A_24_P45620 0.8069 0.06 Ϫ0.42 0.51 UTS2R A_23_P146884 0.4237 0.20 Ϫ0.29 0.61 UTS2R A_23_P146885 0.4910 0.17 Ϫ0.32 0.59 VASH2† A_23_P115492 0.0011 Ϫ0.71 Ϫ0.88 Ϫ0.36 VASH2†† A_24_P85391 0.0827 Ϫ0.42 Ϫ0.74 0.06 VEGFA A_23_P387668 0.6176 Ϫ0.13 Ϫ0.56 0.36 VEGFA A_23_P70398 0.4802 Ϫ0.18 Ϫ0.60 0.32 VEGFA A_23_P70403 0.5919 Ϫ0.14 Ϫ0.57 0.35 VEGFA A_23_P81805 0.8296 Ϫ0.05 Ϫ0.51 0.42 VEGFA A_23_P81806 0.9044 0.03 Ϫ0.44 0.49 VEGFA A_24_P12401 0.8926 0.03 Ϫ0.44 0.49 VEGFA A_24_P179400 0.5462 Ϫ0.15 Ϫ0.58 0.34 VEGFA NKI_NM_003376 0.4897 Ϫ0.17 Ϫ0.59 0.32 VEGFA NM_003376_3_1624 0.8538 0.05 Ϫ0.43 0.50 WNT5A A_23_P211926 0.2746 Ϫ0.27 Ϫ0.66 0.22 WNT5A† A_32_P214010 0.0284 Ϫ0.52 Ϫ0.79 Ϫ0.06 WNT5A†† A_32_P214011 0.0681 Ϫ0.44 Ϫ0.75 0.03 WNT5A A_32_P61911 0.7143 0.09 Ϫ0.39 0.54 WNT5A NM_003392_2_4162 0.2084 Ϫ0.31 Ϫ0.68 0.18 * Indicates positive association P Ͻ 0.05; ** positive association 0.5 Ͻ P Ͻ 0.1; † negative association P Ͻ 0.05; †† negative association 0.5 Ͻ P Ͻ 0.1.

T12 ͉ AJNR ͉͉www.ajnr.org On-line Table 2: Correlation of PS score and expression levels of genes with “negative regulation of angiogenesis” Gene ID Reporter_ID P-value Estimate Lower Upper ADAMTS1* A_23_P211031 0.0467 0.47 0.01 0.77 ADAMTS1* A_23_P211039 0.0442 0.48 0.02 0.77 ADAMTS1* A_23_P342268 0.0436 0.48 0.02 0.77 ADAMTS1** A_23_P342275 0.0533 0.46 Ϫ0.01 0.76 ADAMTS1** NM_006988_2_3723 0.0737 0.43 Ϫ0.04 0.75 AIMP1 Not Measured AMOT A_23_P171227 0.5311 Ϫ0.16 Ϫ0.58 0.33 AMOT A_23_P171229 0.2292 Ϫ0.30 Ϫ0.67 0.20 AMOT† A_23_P171232 0.0304 Ϫ0.51 Ϫ0.79 Ϫ0.06 AMOT A_24_P344956 0.7987 Ϫ0.06 Ϫ0.52 0.41 AMOT A_24_P344961 0.9268 Ϫ0.02 Ϫ0.48 0.45 ANGPT2 A_23_P60079 0.5634 0.15 Ϫ0.34 0.57 ANGPT2 A_24_P367900 0.6282 Ϫ0.12 Ϫ0.56 0.37 ANGPT2 A_24_P932435 0.9000 Ϫ0.03 Ϫ0.49 0.44 ANGPT4 A_23_P68511 0.4758 Ϫ0.18 Ϫ0.60 0.31 APOH A_23_P38244 0.3448 Ϫ0.24 Ϫ0.63 0.26 APOH A_23_P38245 0.4008 Ϫ0.21 Ϫ0.62 0.28 APOH A_32_P92325 0.4767 0.18 Ϫ0.31 0.60 APOH A_32_P92326 0.3551 Ϫ0.23 Ϫ0.63 0.26 BAI1 A_23_P125052 0.8172 0.06 Ϫ0.42 0.51 BAI1 A_23_P125056 0.7351 0.09 Ϫ0.40 0.53 BAI1 A_23_P136448 0.3620 0.23 Ϫ0.27 0.63 CCR2 A_23_P212350 0.8756 0.04 Ϫ0.44 0.50 CCR2 A_23_P212354 0.9486 0.02 Ϫ0.45 0.48 CCR2†† A_23_P324885 0.0847 Ϫ0.42 Ϫ0.74 0.06 CCR2 A_24_P11825 0.7621 0.08 Ϫ0.40 0.52 CD36 A_23_P111581 0.1131 0.39 Ϫ0.10 0.72 CD36 A_23_P111583 0.1938 0.32 Ϫ0.17 0.69 CD36* A_24_P925505 0.0442 0.48 0.02 0.77 CD36 A_32_P117226 0.7658 Ϫ0.08 Ϫ0.52 0.41 CD36 A_32_P117232 0.3400 Ϫ0.24 Ϫ0.63 0.26 CD36 NM_000072_1_1447 0.1105 0.39 Ϫ0.10 0.72 CD36 NM_000072_1_1760 0.2300 0.30 Ϫ0.20 0.67 CDH5 A_23_P129495 0.1436 0.36 Ϫ0.13 0.71 CDH5* A_23_P129496 0.0168 0.56 0.12 0.81 CDH5** NM_001795_2_3394 0.0632 0.45 Ϫ0.03 0.76 CDH5** NM_001795_2_3440 0.0725 0.43 Ϫ0.04 0.75 CHGA A_23_P14595 0.1526 Ϫ0.35 Ϫ0.70 0.14 CHGA A_24_P5061 0.1421 Ϫ0.36 Ϫ0.71 0.13 CHGA A_32_P27046 0.9469 0.02 Ϫ0.45 0.48 CHGA NM_001275_2_1832 0.7581 Ϫ0.08 Ϫ0.53 0.40 COL4A2 A_23_P205031 0.4685 0.18 Ϫ0.31 0.60 COL4A2 NM_001846_1_5986 0.3739 0.22 Ϫ0.27 0.62 COL4A3 A_23_P10678 0.5307 Ϫ0.16 Ϫ0.58 0.33 COL4A3 A_24_P308469 0.1874 Ϫ0.33 Ϫ0.69 0.17 COL4A3 A_24_P308470 0.2829 Ϫ0.27 Ϫ0.65 0.23 CRHR2 A_23_P215331 0.7026 Ϫ0.10 Ϫ0.54 0.39 CX3CR1 A_23_P132401 0.2275 Ϫ0.30 Ϫ0.67 0.19 CX3CR1 A_23_P407565 0.1706 Ϫ0.34 Ϫ0.69 0.15 CX3CR1 A_23_P407566 0.1359 Ϫ0.37 Ϫ0.71 0.12 CX3CR1† NM_001337_2_2738 0.0375 Ϫ0.49 Ϫ0.78 Ϫ0.03 CXCL10 A_24_P303084 0.7725 0.07 Ϫ0.41 0.52 CXCL10 A_24_P303091 0.7707 0.07 Ϫ0.41 0.52 FASLG A_23_P369814 0.5459 Ϫ0.15 Ϫ0.58 0.34 FASLG A_23_P369815 0.8105 0.06 Ϫ0.42 0.51 FASLG A_23_P97646 0.7803 0.07 Ϫ0.41 0.52 FASLG A_24_P54220 0.8303 0.05 Ϫ0.42 0.51 FASLG A_24_P54223 0.6315 0.12 Ϫ0.37 0.56 FASLG NM_000639_1_1682 0.7841 0.07 Ϫ0.41 0.52 FOXO4 A_23_P217483 0.6914 0.10 Ϫ0.38 0.54 FOXO4 A_23_P217487 0.7986 Ϫ0.06 Ϫ0.52 0.41 FOXO4 A_24_P379159 0.1605 Ϫ0.35 Ϫ0.70 0.14 FOXO4 A_24_P379165 0.9011 Ϫ0.03 Ϫ0.49 0.44 FOXO6 Not Measured (Continued)

AJNR Am J Neuroradiol ͉͉www.ajnr.org T13 On-line Table 2: Continued Gene ID Reporter_ID P-value Estimate Lower Upper GHRL A_23_P40954 0.8438 Ϫ0.05 Ϫ0.51 0.43 GHRL A_23_P40956 0.6384 Ϫ0.12 Ϫ0.55 0.37 HHEX A_23_P47034 0.9189 0.03 Ϫ0.45 0.49 HOXA5 A_23_P93769 0.1413 Ϫ0.36 Ϫ0.71 0.13 HOXA5 A_23_P93772 0.1136 Ϫ0.39 Ϫ0.72 0.10 HOXA5 A_23_P93773 0.1019 Ϫ0.40 Ϫ0.73 0.08 IL17F A_23_P167882 0.4669 Ϫ0.18 Ϫ0.60 0.31 KLK3 A_23_P208665 0.6905 Ϫ0.10 Ϫ0.54 0.38 KLK3 A_23_P208669 0.2313 Ϫ0.30 Ϫ0.67 0.20 KLK3 A_23_P334538 0.1487 Ϫ0.35 Ϫ0.70 0.13 KLK3 A_24_P108401 0.8031 Ϫ0.06 Ϫ0.51 0.42 KLK3 A_24_P108402 0.6657 0.11 Ϫ0.38 0.55 KLK3 A_24_P344510 0.2027 Ϫ0.32 Ϫ0.68 0.18 KLK3* NM_001648_2_932 0.0221 0.54 0.09 0.80 LECT1 A_23_P25587 0.2740 0.27 Ϫ0.22 0.66 LIF A_23_P155017 0.5204 Ϫ0.16 Ϫ0.58 0.33 LIF A_24_P122136 0.7966 Ϫ0.07 Ϫ0.52 0.41 LIF A_24_P122137 0.8002 Ϫ0.06 Ϫ0.52 0.42 LIF A_24_P233488 0.9686 Ϫ0.01 Ϫ0.47 0.46 LIF A_24_P233489 0.5567 Ϫ0.15 Ϫ0.58 0.34 LIF NM_002309_2_3647 0.6523 Ϫ0.11 Ϫ0.55 0.37 LOC100138545 Not Measured NF1† A_23_P207596 0.0469 Ϫ0.47 Ϫ0.77 Ϫ0.01 NF1 A_24_P1919 0.3873 Ϫ0.22 Ϫ0.62 0.28 NF1 A_24_P917026 0.6176 Ϫ0.13 Ϫ0.56 0.36 NPPB†† A_23_P62748 0.0812 Ϫ0.42 Ϫ0.74 0.06 NPPB†† A_23_P62752 0.0592 Ϫ0.45 Ϫ0.76 0.02 NPPB A_23_P62753 0.1036 Ϫ0.40 Ϫ0.73 0.09 NPR1 A_23_P147707 0.1147 0.38 Ϫ0.10 0.72 NPR1 A_23_P147711 0.2974 0.26 Ϫ0.24 0.65 PF4 A_23_P132987 0.8123 0.06 Ϫ0.42 0.51 PF4 A_24_P79402 0.9082 0.03 Ϫ0.44 0.49 PF4 A_24_P79403 0.8962 0.03 Ϫ0.44 0.49 PLG A_23_P30693 0.3471 Ϫ0.24 Ϫ0.63 0.26 PLG A_23_P30694 0.6772 0.11 Ϫ0.38 0.55 PLG A_24_P240487 0.4806 Ϫ0.18 Ϫ0.60 0.32 PLG A_32_P206123 0.3702 Ϫ0.22 Ϫ0.63 0.27 PLG A_32_P206124 0.8141 Ϫ0.06 Ϫ0.51 0.42 PLG NM_000301_1_2597 0.3297 Ϫ0.24 Ϫ0.64 0.25 PML A_23_P205961 0.3254 0.25 Ϫ0.25 0.64 PML A_23_P306141 0.7597 Ϫ0.08 Ϫ0.53 0.40 PML A_23_P306148 0.5138 0.16 Ϫ0.33 0.59 PML A_23_P334664 0.3772 0.22 Ϫ0.27 0.62 PML A_23_P358944 0.6759 Ϫ0.11 Ϫ0.55 0.38 PML A_23_P358945 0.7933 Ϫ0.07 Ϫ0.52 0.41 PML* A_24_P133542 0.0354 0.50 0.04 0.78 PML A_24_P198598 0.8501 Ϫ0.05 Ϫ0.50 0.43 PML A_24_P207138 0.2480 0.29 Ϫ0.21 0.66 PML A_24_P207139 0.5348 0.16 Ϫ0.33 0.58 PTPRM* A_23_P159255 0.0000 0.82 0.57 0.93 PTPRM* A_23_P159264 0.0004 0.75 0.43 0.90 PTPRM* A_23_P255541 0.0001 0.80 0.53 0.92 PTPRM* NM_002845_2_4927 0.0006 0.73 0.40 0.89 SERPINF1 A_23_P100660 0.7005 0.10 Ϫ0.39 0.54 SERPINF1 A_23_P100662 0.4529 0.19 Ϫ0.30 0.60 SERPINF1 NM_002615_1_1081 0.7697 0.07 Ϫ0.41 0.52 SPINK5 A_23_P10251 0.1826 Ϫ0.33 Ϫ0.69 0.16 SPINK5 A_23_P356494 0.1214 Ϫ0.38 Ϫ0.72 0.11 STAB1 A_23_P32499 0.2867 0.27 Ϫ0.23 0.65 STAB1 A_23_P32500 0.2563 0.28 Ϫ0.21 0.66 STAB1** A_23_P32501 0.0797 0.42 Ϫ0.05 0.74 STAB1 A_24_P119456 0.7379 0.08 Ϫ0.40 0.53 THBS1 A_23_P206210 0.4339 0.20 Ϫ0.30 0.61 (Continued)

T14 ͉ AJNR ͉͉www.ajnr.org On-line Table 2: Continued Gene ID Reporter_ID P-value Estimate Lower Upper THBS1 A_23_P206212 0.3951 0.21 Ϫ0.28 0.62 THBS1 A_32_P17173 0.9971 0.00 Ϫ0.47 0.47 THBS1 A_32_P17182 0.9151 0.03 Ϫ0.45 0.49 THBS2 A_23_P253651 0.2780 0.27 Ϫ0.22 0.65 THBS2 A_23_P253652 0.2346 0.30 Ϫ0.20 0.67 THBS2 A_23_P62021 0.2257 0.30 Ϫ0.19 0.67 THBS2** A_24_P605620 0.0738 0.43 Ϫ0.04 0.75 THBS4* A_23_P250362 0.0324 0.51 0.05 0.79 THBS4 A_23_P250363 0.3607 0.23 Ϫ0.27 0.63 THBS4 A_24_P260443 0.2000 0.32 Ϫ0.18 0.68 TIE1 A_23_P126413 0.1642 0.34 Ϫ0.15 0.70 TIE1* A_23_P126416 0.0389 0.49 0.03 0.78 TIE1 A_23_P126422 0.1708 0.34 Ϫ0.15 0.69 UNC5B A_23_P52336 0.5312 0.16 Ϫ0.33 0.58 UNC5B A_23_P52337 0.5028 0.17 Ϫ0.32 0.59 VASH1 A_23_P76998 0.8089 0.06 Ϫ0.42 0.51 VASH1 A_23_P77000 0.8349 Ϫ0.05 Ϫ0.51 0.42 VASH1 A_23_P77002 0.7429 Ϫ0.08 Ϫ0.53 0.40 VASH1 A_24_P304628 0.4045 0.21 Ϫ0.29 0.62 VASH1 A_24_P304629 0.3497 0.23 Ϫ0.26 0.63 WISP3 A_23_P81676 0.6914 Ϫ0.10 Ϫ0.54 0.38 * Indicates positive association P Ͻ 0.05; ** positive association 0.5 Ͻ P Ͻ 0.1; † negative association P Ͻ 0.05; †† negative association 0.5 Ͻ P Ͻ 0.1.

AJNR Am J Neuroradiol ͉͉www.ajnr.org T15 On-line Table 3: Correlation of CBV score and expression levels of genes with “positive regulation of angiogenesis” Gene ID Reporter_ID P-value Estimate Lower Upper AAMP A_23_P56528 0.9713 Ϫ0.01 Ϫ0.47 0.46 AAMP A_23_P56529 0.8999 Ϫ0.03 Ϫ0.49 0.44 AGGF1 A_23_P250551 0.7175 0.09 Ϫ0.39 0.54 AGGF1 A_23_P250554 0.4381 0.19 Ϫ0.30 0.61 AGGF1 A_23_P250559 0.4191 0.20 Ϫ0.29 0.61 AGGF1 A_23_P41969 0.3191 Ϫ0.25 Ϫ0.64 0.25 AGGF1 A_23_P41970 0.3445 Ϫ0.24 Ϫ0.63 0.26 AGGF1 A_24_P256513 0.6582 Ϫ0.11 Ϫ0.55 0.37 AGGF1 A_24_P256520 0.5893 0.14 Ϫ0.35 0.57 ANGPT2 A_23_P60079 0.6660 0.11 Ϫ0.38 0.55 ANGPT2 A_24_P367900 0.7042 Ϫ0.10 Ϫ0.54 0.39 ANGPT2 A_24_P932435 0.6677 Ϫ0.11 Ϫ0.55 0.38 ANGPT4 A_23_P68511 0.8036 Ϫ0.06 Ϫ0.51 0.42 ANGPTL3 A_23_P160261 0.4579 0.19 Ϫ0.31 0.60 ANGPTL3 A_23_P160262 0.5390 0.16 Ϫ0.34 0.58 ANGPTL4 A_23_P159325 0.7362 0.09 Ϫ0.40 0.53 ANGPTL4 A_23_P159328 0.7543 0.08 Ϫ0.40 0.53 ANGPTL4 A_23_P159330 0.7315 0.09 Ϫ0.40 0.53 ANGPTL4 A_23_P170716 0.6150 0.13 Ϫ0.36 0.56 ANGPTL4 NM_139314_1_1810 0.7307 0.09 Ϫ0.40 0.53 ANXA3 A_23_P121712 0.3097 Ϫ0.25 Ϫ0.64 0.24 ANXA3 A_23_P121716 0.2582 Ϫ0.28 Ϫ0.66 0.21 AQP1 A_23_P19894 0.5331 Ϫ0.16 Ϫ0.58 0.33 AQP1 A_23_P19895 0.6352 Ϫ0.12 Ϫ0.56 0.37 AQP1 A_23_P372834 0.3319 Ϫ0.24 Ϫ0.64 0.25 AQP1 BC022486_1_2437 0.7064 Ϫ0.10 Ϫ0.54 0.39 BTG1 A_23_P87560 0.4125 0.21 Ϫ0.29 0.61 BTG1 A_23_P87563 0.4392 0.19 Ϫ0.30 0.61 BTG1 A_23_P87564 0.4900 0.17 Ϫ0.32 0.59 BTG1 A_32_P225865 0.9038 Ϫ0.03 Ϫ0.49 0.44 BTG1 A_32_P225870 0.7594 0.08 Ϫ0.40 0.53 C3† A_23_P101400 0.0282 Ϫ0.52 Ϫ0.79 Ϫ0.07 C3† A_23_P101405 0.0230 Ϫ0.53 Ϫ0.80 Ϫ0.09 C3† A_23_P101407 0.0256 Ϫ0.52 Ϫ0.80 Ϫ0.08 C3† A_32_P123697 0.0067 Ϫ0.61 Ϫ0.84 Ϫ0.21 C3† A_32_P123701 0.0051 Ϫ0.63 Ϫ0.85 Ϫ0.23 C3† NM_000064_1_4175 0.0452 Ϫ0.48 Ϫ0.77 Ϫ0.01 C3AR1 A_23_P2431 0.7975 0.07 Ϫ0.41 0.52 C3AR1 A_23_P2432 0.5807 0.14 Ϫ0.35 0.57 C5 A_23_P71855 0.3894 Ϫ0.22 Ϫ0.62 0.28 C5 A_23_P71856 0.4471 Ϫ0.19 Ϫ0.60 0.30 C5AR1 A_23_P153560 0.3017 Ϫ0.26 Ϫ0.65 0.24 C5AR1 A_23_P153562 0.4286 Ϫ0.20 Ϫ0.61 0.30 C5AR1 A_23_P303051 0.3628 Ϫ0.23 Ϫ0.63 0.27 C5AR1 A_23_P303058 0.9905 0.00 Ϫ0.46 0.47 C6 A_23_P92920 0.5639 Ϫ0.15 Ϫ0.57 0.34 C6 A_23_P92925 0.7916 Ϫ0.07 Ϫ0.52 0.41 C6 A_23_P92928 0.7885 Ϫ0.07 Ϫ0.52 0.41 CAMP A_23_P253791 0.1516 Ϫ0.35 Ϫ0.70 0.14 CAMP A_23_P253792 0.1408 Ϫ0.36 Ϫ0.71 0.13 CCL11 A_23_P66627 0.4982 0.17 Ϫ0.32 0.59 CCL11 A_23_P66635 0.1885 0.32 Ϫ0.17 0.69 CCL24 A_23_P215491 0.9829 0.01 Ϫ0.46 0.47 CCR3 A_23_P250302 0.3136 0.25 Ϫ0.24 0.64 CCR3 A_24_P367473 0.2975 Ϫ0.26 Ϫ0.65 0.24 CCR3 A_24_P367481 0.6646 Ϫ0.11 Ϫ0.55 0.38 CHRNA7 A_23_P163388 0.7514 0.08 Ϫ0.40 0.53 CHRNA7 A_23_P163390 0.8782 0.04 Ϫ0.44 0.50 CX3CL1 A_23_P37724 0.8233 0.06 Ϫ0.42 0.51 CX3CL1 A_23_P37727 0.6816 0.10 Ϫ0.38 0.54 CX3CL1 A_24_P381901 0.5878 Ϫ0.14 Ϫ0.57 0.35 CX3CL1 A_24_P381906 0.4739 Ϫ0.18 Ϫ0.60 0.31 CX3CL1 A_24_P390490 0.3112 0.25 Ϫ0.24 0.64 CX3CL1 A_24_P390495 0.7153 0.09 Ϫ0.39 0.54 CX3CL1 NM_002996_1_3128 0.6120 0.13 Ϫ0.36 0.56 CX3CL1 NM_002996_1_3198 0.6709 0.11 Ϫ0.38 0.55 CX3CL1 Not Measured (Continued)

T16 ͉ AJNR ͉͉www.ajnr.org On-line Table 3: Continued Gene ID Reporter_ID P-value Estimate Lower Upper CX3CL1 Not Measured CYR61 A_23_P46426 0.6142 0.13 Ϫ0.36 0.56 CYR61 A_23_P46429 0.5784 0.14 Ϫ0.35 0.57 CYR61 A_24_P370946 0.4985 0.17 Ϫ0.32 0.59 CYR61 A_32_P58356 0.7820 0.07 Ϫ0.41 0.52 CYR61 A_32_P58361 0.9033 0.03 Ϫ0.44 0.49 CYR61 NM_001554_1_1729 0.6257 0.12 Ϫ0.36 0.56 DDAH1 A_23_P201380 0.7425 0.08 Ϫ0.40 0.53 DDAH1 A_23_P201386 0.4489 0.19 Ϫ0.30 0.60 DDAH1 A_32_P165407 0.9589 Ϫ0.01 Ϫ0.48 0.46 DDAH1 AK098405_1_2813 0.5701 0.14 Ϫ0.35 0.57 ECM1** A_23_P149180 0.0573 0.46 Ϫ0.01 0.76 ECM1 A_23_P160559 0.2752 0.27 Ϫ0.22 0.66 ECM1 A_23_P160563 0.3010 0.26 Ϫ0.24 0.65 ECM1 AK097205_1_2918 0.4192 0.20 Ϫ0.29 0.61 ERAP1 Not Measured EREG A_23_P41344 0.7458 Ϫ0.08 Ϫ0.53 0.40 EREG A_23_P41347 0.3364 Ϫ0.24 Ϫ0.64 0.26 EREG A_24_P217520 0.7453 0.08 Ϫ0.40 0.53 EREG A_24_P217522 0.7327 Ϫ0.09 Ϫ0.53 0.40 EREG NM_001432_1_3866 0.6035 Ϫ0.13 Ϫ0.56 0.36 ETS1 A_23_P127525 0.3522 0.23 Ϫ0.26 0.63 ETS1 A_23_P329212 0.8374 Ϫ0.05 Ϫ0.51 0.43 ETS1 A_24_P136670 0.4425 0.19 Ϫ0.30 0.61 F3 A_23_P115382 0.1702 Ϫ0.34 Ϫ0.70 0.15 F3 A_23_P126782 0.5940 Ϫ0.13 Ϫ0.57 0.35 FGF2 A_23_P155855 0.5350 0.16 Ϫ0.33 0.58 FGF2 A_23_P155857 0.2737 0.27 Ϫ0.22 0.66 FGF2 A_23_P218910 0.5494 0.15 Ϫ0.34 0.58 FGF2 A_23_P218918 0.8737 Ϫ0.04 Ϫ0.50 0.43 FIGF A_23_P33796 0.3926 Ϫ0.21 Ϫ0.62 0.28 FIGF A_23_P45185 0.3075 Ϫ0.25 Ϫ0.64 0.24 GATA2 A_23_P110022 0.9201 Ϫ0.03 Ϫ0.49 0.45 GATA2 A_24_P165998 0.5320 0.16 Ϫ0.33 0.58 GATA2 A_24_P166000 0.9366 0.02 Ϫ0.45 0.48 GATA4 A_23_P384754 0.5713 Ϫ0.14 Ϫ0.57 0.35 GATA4 A_23_P384761 0.9939 0.00 Ϫ0.47 0.47 GATA4 A_23_P82722 0.2859 Ϫ0.27 Ϫ0.65 0.23 HIF1A A_23_P427158 0.5960 0.13 Ϫ0.36 0.57 HIF1A A_24_P56388 0.3565 0.23 Ϫ0.26 0.63 HIF1A NM_001530_1_3499 0.5543 0.15 Ϫ0.34 0.58 HMOX1 A_23_P120883 0.5381 Ϫ0.16 Ϫ0.58 0.34 HMOX1 A_23_P120884 0.6162 Ϫ0.13 Ϫ0.56 0.36 HMOX1 NM_002133_1_1231 0.6935 Ϫ0.10 Ϫ0.54 0.38 IL1A† A_23_P72096 0.0187 Ϫ0.55 Ϫ0.81 Ϫ0.11 IL1A† A_24_P45892 0.0276 Ϫ0.52 Ϫ0.79 Ϫ0.07 IL1A† NM_000575_3_2535 0.0312 Ϫ0.51 Ϫ0.79 Ϫ0.05 IL1A† NM_000575_3_2635 0.0270 Ϫ0.52 Ϫ0.79 Ϫ0.07 IL1B†† A_23_P79518 0.0973 Ϫ0.40 Ϫ0.73 0.08 IL1B†† A_23_P79523 0.0756 Ϫ0.43 Ϫ0.75 0.05 IL1B NM_000576_2_853 0.1361 Ϫ0.37 Ϫ0.71 0.12 ITGB2 A_23_P211180 0.4386 Ϫ0.19 Ϫ0.61 0.30 ITGB2 A_23_P329570 0.5951 Ϫ0.13 Ϫ0.57 0.35 ITGB2 A_23_P329573 0.5158 Ϫ0.16 Ϫ0.59 0.33 ITGB2 A_23_P430411 0.2278 Ϫ0.30 Ϫ0.67 0.19 ITGB2 A_23_P430412 0.7486 Ϫ0.08 Ϫ0.53 0.40 ITGB2 NM_000211_1_1938 0.9388 Ϫ0.02 Ϫ0.48 0.45 KDR A_23_P58416 0.1896 0.32 Ϫ0.17 0.69 KDR** A_23_P58419 0.0501 0.47 0.00 0.77 KDR* A_24_P71973 0.0406 0.49 0.03 0.78 KDR* NM_002253_1_5246 0.0084 0.60 0.19 0.83 KDR** NM_002253_1_5290 0.0805 0.42 Ϫ0.05 0.74 MMP9 A_23_P40174 0.1830 0.33 Ϫ0.16 0.69 MMP9 A_23_P40175 0.2345 0.30 Ϫ0.20 0.67 MMP9 NKI_NM_004994 0.2240 0.30 Ϫ0.19 0.67 MMP9** NM_004994_1_1525 0.0833 0.42 Ϫ0.06 0.74 MMP9 NM_004994_1_1989 0.2034 0.31 Ϫ0.18 0.68 (Continued)

AJNR Am J Neuroradiol ͉͉www.ajnr.org T17 On-line Table 3: Continued Gene ID Reporter_ID P-value Estimate Lower Upper NOS3 A_23_P70849 0.9423 Ϫ0.02 Ϫ0.48 0.45 NOS3 A_23_P70850 0.8253 0.06 Ϫ0.42 0.51 PLCG1 A_24_P100049 0.9287 Ϫ0.02 Ϫ0.48 0.45 RHOB A_23_P51136 0.7646 Ϫ0.08 Ϫ0.52 0.41 RHOB A_23_P51140 0.8405 Ϫ0.05 Ϫ0.51 0.43 RHOB NM_004040_1_532 0.9313 Ϫ0.02 Ϫ0.48 0.45 RUNX1 A_24_P34155 0.9718 Ϫ0.01 Ϫ0.47 0.46 RUNX1 A_24_P34157 0.9768 Ϫ0.01 Ϫ0.47 0.46 RUNX1 A_24_P96403 0.6688 0.11 Ϫ0.38 0.55 RUNX1 A_24_P96404 0.7740 0.07 Ϫ0.41 0.52 SERPINE1 A_24_P158089 0.9075 0.03 Ϫ0.44 0.49 SERPINE1 A_32_P10401 0.8719 0.04 Ϫ0.43 0.50 SERPINE1 A_32_P10403 0.9719 0.01 Ϫ0.46 0.47 SERPINE1 NM_000602_1_2134 0.9680 0.01 Ϫ0.46 0.47 SERPINE1 NM_000602_1_2386 0.8429 0.05 Ϫ0.43 0.51 SFRP2 A_23_P81098 0.2513 0.29 Ϫ0.21 0.66 SFRP2 A_23_P81103 0.3163 0.25 Ϫ0.25 0.64 SFRP2 A_24_P137501 0.4195 0.20 Ϫ0.29 0.61 SFRP2 A_24_P137502 0.4287 0.20 Ϫ0.30 0.61 SFRP2 A_24_P934546 0.3397 0.24 Ϫ0.26 0.63 SFRP2 AK093922_1_1403 0.4783 0.18 Ϫ0.31 0.60 SPHK1 A_23_P38104 0.8777 Ϫ0.04 Ϫ0.50 0.44 SPHK1 A_23_P38106 0.9101 Ϫ0.03 Ϫ0.49 0.44 TBXA2R A_23_P355471 0.6887 0.10 Ϫ0.38 0.54 TBXA2R A_23_P90355 0.2998 0.26 Ϫ0.24 0.65 TBXA2R A_23_P90357 0.4079 0.21 Ϫ0.29 0.62 TEK** A_23_P216822 0.0803 0.42 Ϫ0.05 0.74 TEK* A_23_P374694 0.0141 0.57 0.14 0.82 TEK* A_23_P374695 0.0119 0.58 0.15 0.82 TEK* A_23_P374699 0.0355 0.50 0.04 0.78 THBS1 A_23_P206210 0.4032 0.21 Ϫ0.28 0.62 THBS1 A_23_P206212 0.3615 0.23 Ϫ0.27 0.63 THBS1 A_32_P17173 0.2985 0.26 Ϫ0.24 0.65 THBS1 A_32_P17182 0.5937 0.13 Ϫ0.35 0.57 TNFRSF1A A_23_P139715 0.3673 Ϫ0.23 Ϫ0.63 0.27 TNFRSF1A A_23_P139716 0.4107 Ϫ0.21 Ϫ0.61 0.29 TNFRSF1A A_23_P139722 0.6051 Ϫ0.13 Ϫ0.56 0.36 TNFRSF1A A_24_P364359 0.9504 0.02 Ϫ0.45 0.48 TNFRSF1A A_24_P364363 0.9357 Ϫ0.02 Ϫ0.48 0.45 TNFRSF1A NM_001065_2_2074 0.4546 Ϫ0.19 Ϫ0.60 0.31 TNFSF12 A_23_P141224 0.5380 Ϫ0.16 Ϫ0.58 0.34 TNFSF12 A_23_P141233 0.6428 Ϫ0.12 Ϫ0.55 0.37 TNFSF12 A_24_P245298 0.7156 Ϫ0.09 Ϫ0.54 0.39 UTS2 A_23_P63340 0.6454 Ϫ0.12 Ϫ0.55 0.37 UTS2 A_23_P63343 0.8305 Ϫ0.05 Ϫ0.51 0.42 UTS2 A_24_P45620 0.8373 Ϫ0.05 Ϫ0.51 0.43 UTS2R A_23_P146884 0.9974 0.00 Ϫ0.47 0.47 UTS2R A_23_P146885 0.9479 0.02 Ϫ0.45 0.48 VASH2 A_23_P115492 0.2641 Ϫ0.28 Ϫ0.66 0.22 VASH2 A_24_P85391 0.1568 Ϫ0.35 Ϫ0.70 0.14 VEGFA A_23_P387668 0.6317 Ϫ0.12 Ϫ0.56 0.37 VEGFA A_23_P70398 0.5804 Ϫ0.14 Ϫ0.57 0.35 VEGFA A_23_P70403 0.6137 Ϫ0.13 Ϫ0.56 0.36 VEGFA A_23_P81805 0.9709 0.01 Ϫ0.46 0.47 VEGFA A_23_P81806 0.8386 0.05 Ϫ0.43 0.51 VEGFA A_24_P12401 0.6823 0.10 Ϫ0.38 0.54 VEGFA A_24_P179400 0.3949 Ϫ0.21 Ϫ0.62 0.28 VEGFA NKI_NM_003376 0.5698 Ϫ0.14 Ϫ0.57 0.35 VEGFA NM_003376_3_1624 0.7628 0.08 Ϫ0.40 0.52 WNT5A A_23_P211926 0.8311 Ϫ0.05 Ϫ0.51 0.42 WNT5A A_32_P214010 0.7850 Ϫ0.07 Ϫ0.52 0.41 WNT5A A_32_P214011 0.8139 Ϫ0.06 Ϫ0.51 0.42 WNT5A A_32_P61911 0.7398 0.08 Ϫ0.40 0.53 WNT5A NM_003392_2_4162 0.6833 Ϫ0.10 Ϫ0.54 0.38 * Indicates positive association P Ͻ 0.05; ** positive association 0.5 Ͻ P Ͻ 0.1; † negative association P Ͻ 0.05; †† negative association 0.5 Ͻ P Ͻ 0.1.

T18 ͉ AJNR ͉͉www.ajnr.org On-line Table 4: Correlation of CBV score and expression levels of genes with “negative regulation of angiogenesis” Gene ID Reporter_ID P-value Estimate Lower Upper ADAMTS1 A_23_P211031 0.9978 0.00 Ϫ0.47 0.47 ADAMTS1 A_23_P211039 0.9564 0.01 Ϫ0.46 0.48 ADAMTS1 A_23_P342268 0.9977 0.00 Ϫ0.47 0.47 ADAMTS1 A_23_P342275 0.9351 Ϫ0.02 Ϫ0.48 0.45 ADAMTS1 NM_006988_2_3723 0.9002 Ϫ0.03 Ϫ0.49 0.44 AIMP1 Not Measured AMOT A_23_P171227 0.9708 Ϫ0.01 Ϫ0.47 0.46 AMOT A_23_P171229 0.4652 Ϫ0.18 Ϫ0.60 0.31 AMOT A_23_P171232 0.1595 Ϫ0.35 Ϫ0.70 0.14 AMOT A_24_P344956 0.5986 Ϫ0.13 Ϫ0.56 0.36 AMOT A_24_P344961 0.9275 Ϫ0.02 Ϫ0.48 0.45 ANGPT2 A_23_P60079 0.6660 0.11 Ϫ0.38 0.55 ANGPT2 A_24_P367900 0.7042 Ϫ0.10 Ϫ0.54 0.39 ANGPT2 A_24_P932435 0.6677 Ϫ0.11 Ϫ0.55 0.38 ANGPT4 A_23_P68511 0.8036 Ϫ0.06 Ϫ0.51 0.42 APOH A_23_P38244 0.2540 Ϫ0.28 Ϫ0.66 0.21 APOH A_23_P38245 0.2123 Ϫ0.31 Ϫ0.68 0.18 APOH A_32_P92325 0.6089 0.13 Ϫ0.36 0.56 APOH A_32_P92326 0.7056 Ϫ0.10 Ϫ0.54 0.39 BAI1 A_23_P125052 0.6753 0.11 Ϫ0.38 0.55 BAI1 A_23_P125056 0.5495 0.15 Ϫ0.34 0.58 BAI1 A_23_P136448 0.3740 0.22 Ϫ0.27 0.62 CCR2 A_23_P212350 0.9263 0.02 Ϫ0.45 0.49 CCR2 A_23_P212354 0.8121 0.06 Ϫ0.42 0.51 CCR2 A_23_P324885 0.2344 Ϫ0.30 Ϫ0.67 0.20 CCR2 A_24_P11825 0.7990 0.06 Ϫ0.41 0.52 CD36* A_23_P111581 0.0270 0.52 0.07 0.79 CD36* A_23_P111583 0.0157 0.56 0.13 0.81 CD36* A_24_P925505 0.0073 0.61 0.20 0.84 CD36 A_32_P117226 0.1359 0.37 Ϫ0.12 0.71 CD36 A_32_P117232 0.3298 0.24 Ϫ0.25 0.64 CD36* NM_000072_1_1447 0.0195 0.54 0.10 0.81 CD36* NM_000072_1_1760 0.0261 0.52 0.07 0.80 CDH5 A_23_P129495 0.4695 0.18 Ϫ0.31 0.60 CDH5 A_23_P129496 0.2220 0.30 Ϫ0.19 0.67 CDH5 NM_001795_2_3394 0.3066 0.26 Ϫ0.24 0.65 CDH5 NM_001795_2_3440 0.1517 0.35 Ϫ0.14 0.70 CHGA A_23_P14595 0.1710 Ϫ0.34 Ϫ0.69 0.15 CHGA A_24_P5061 0.1529 Ϫ0.35 Ϫ0.70 0.14 CHGA A_32_P27046 0.7155 Ϫ0.09 Ϫ0.54 0.39 CHGA NM_001275_2_1832 0.7413 Ϫ0.08 Ϫ0.53 0.40 COL4A2 A_23_P205031 0.1807 0.33 Ϫ0.16 0.69 COL4A2 NM_001846_1_5986 0.1048 0.39 Ϫ0.09 0.73 COL4A3 A_23_P10678 0.1782 Ϫ0.33 Ϫ0.69 0.16 COL4A3 A_24_P308469 0.1032 Ϫ0.40 Ϫ0.73 0.09 COL4A3 A_24_P308470 0.2031 Ϫ0.31 Ϫ0.68 0.18 CRHR2 A_23_P215331 0.5078 0.17 Ϫ0.33 0.59 CX3CR1 A_23_P132401 0.1304 Ϫ0.37 Ϫ0.71 0.12 CX3CR1† A_23_P407565 0.0028 Ϫ0.66 Ϫ0.86 Ϫ0.28 CX3CR1† A_23_P407566 0.0031 Ϫ0.66 Ϫ0.86 Ϫ0.27 CX3CR1† NM_001337_2_2738 0.0068 Ϫ0.61 Ϫ0.84 Ϫ0.21 CXCL10 A_24_P303084 0.6052 Ϫ0.13 Ϫ0.56 0.36 CXCL10 A_24_P303091 0.5224 Ϫ0.16 Ϫ0.58 0.33 FASLG A_23_P369814 0.5975 Ϫ0.13 Ϫ0.57 0.36 FASLG A_23_P369815 0.8394 Ϫ0.05 Ϫ0.51 0.43 FASLG A_23_P97646 0.9879 0.00 Ϫ0.46 0.47 FASLG A_24_P54220 0.1886 Ϫ0.32 Ϫ0.69 0.17 FASLG A_24_P54223 0.7814 Ϫ0.07 Ϫ0.52 0.41 FASLG NM_000639_1_1682 0.5943 Ϫ0.13 Ϫ0.57 0.35 FOXO4 A_23_P217483 0.2495 Ϫ0.29 Ϫ0.66 0.21 FOXO4 A_23_P217487 0.8748 Ϫ0.04 Ϫ0.50 0.43 FOXO4 A_24_P379159 0.3546 Ϫ0.23 Ϫ0.63 0.26 FOXO4 A_24_P379165 0.1481 0.36 Ϫ0.13 0.71 FOXO6 Not Measured GHRL A_23_P40954 0.3901 Ϫ0.22 Ϫ0.62 0.28 GHRL A_23_P40956 0.3015 Ϫ0.26 Ϫ0.65 0.24 HHEX A_23_P47034 0.7973 Ϫ0.07 Ϫ0.52 0.41 HOXA5 A_23_P93769 0.2593 Ϫ0.28 Ϫ0.66 0.21 (Continued)

AJNR Am J Neuroradiol ͉͉www.ajnr.org T19 On-line Table 4: Continued Gene ID Reporter_ID P-value Estimate Lower Upper HOXA5 A_23_P93772 0.1770 Ϫ0.33 Ϫ0.69 0.16 HOXA5 A_23_P93773 0.2040 Ϫ0.31 Ϫ0.68 0.18 IL17F A_23_P167882 0.8690 Ϫ0.04 Ϫ0.50 0.43 KLK3 A_23_P208665 0.3058 Ϫ0.26 Ϫ0.65 0.24 KLK3 A_23_P208669 0.3239 Ϫ0.25 Ϫ0.64 0.25 KLK3 A_23_P334538 0.1406 Ϫ0.36 Ϫ0.71 0.13 KLK3 A_24_P108401 0.6675 Ϫ0.11 Ϫ0.55 0.38 KLK3 A_24_P108402 0.9881 0.00 Ϫ0.47 0.46 KLK3 A_24_P344510 0.4210 Ϫ0.20 Ϫ0.61 0.29 KLK3** NM_001648_2_932 0.0856 0.42 Ϫ0.06 0.74 LECT1 A_23_P25587 0.6370 0.12 Ϫ0.37 0.56 LIF A_23_P155017 0.1299 Ϫ0.37 Ϫ0.71 0.12 LIF A_24_P122136 0.2229 Ϫ0.30 Ϫ0.67 0.19 LIF A_24_P122137 0.2444 Ϫ0.29 Ϫ0.67 0.21 LIF A_24_P233488 0.4631 Ϫ0.18 Ϫ0.60 0.31 LIF A_24_P233489 0.5371 Ϫ0.16 Ϫ0.58 0.34 LIF NM_002309_2_3647 0.1951 Ϫ0.32 Ϫ0.68 0.17 LOC100138545 Not Measured NF1 A_23_P207596 0.6455 0.12 Ϫ0.37 0.55 NF1 A_24_P1919 0.4688 Ϫ0.18 Ϫ0.60 0.31 NF1 A_24_P917026 0.8239 0.06 Ϫ0.42 0.51 NPPB A_23_P62748 0.2137 Ϫ0.31 Ϫ0.68 0.19 NPPB A_23_P62752 0.3806 Ϫ0.22 Ϫ0.62 0.28 NPPB A_23_P62753 0.6969 Ϫ0.10 Ϫ0.54 0.39 NPR1 A_23_P147707 0.1349 0.37 Ϫ0.12 0.71 NPR1 A_23_P147711 0.1944 0.32 Ϫ0.17 0.69 PF4 A_23_P132987 0.5222 0.16 Ϫ0.33 0.58 PF4 A_24_P79402 0.7990 0.06 Ϫ0.41 0.52 PF4 A_24_P79403 0.7506 0.08 Ϫ0.40 0.53 PLG A_23_P30693 0.7450 0.08 Ϫ0.40 0.53 PLG A_23_P30694 0.2282 0.30 Ϫ0.20 0.67 PLG A_24_P240487 0.9632 0.01 Ϫ0.46 0.48 PLG A_32_P206123 0.9655 Ϫ0.01 Ϫ0.48 0.46 PLG A_32_P206124 0.2119 0.31 Ϫ0.18 0.68 PLG NM_000301_1_2597 0.4686 Ϫ0.18 Ϫ0.60 0.31 PML A_23_P205961 0.4049 Ϫ0.21 Ϫ0.62 0.29 PML A_23_P306141 0.5264 Ϫ0.16 Ϫ0.58 0.33 PML A_23_P306148 0.7744 Ϫ0.07 Ϫ0.52 0.41 PML A_23_P334664 0.6719 Ϫ0.11 Ϫ0.55 0.38 PML A_23_P358944 0.1380 Ϫ0.36 Ϫ0.71 0.12 PML A_23_P358945 0.2161 Ϫ0.31 Ϫ0.68 0.19 PML A_24_P133542 0.1449 0.36 Ϫ0.13 0.71 PML A_24_P198598 0.5276 Ϫ0.16 Ϫ0.58 0.33 PML A_24_P207138 0.7465 Ϫ0.08 Ϫ0.53 0.40 PML A_24_P207139 0.3533 Ϫ0.23 Ϫ0.63 0.26 PTPRM** A_23_P159255 0.0677 0.44 Ϫ0.03 0.75 PTPRM* A_23_P159264 0.0495 0.47 0.00 0.77 PTPRM** A_23_P255541 0.0548 0.46 Ϫ0.01 0.76 PTPRM NM_002845_2_4927 0.2371 0.29 Ϫ0.20 0.67 SERPINF1 A_23_P100660 0.6349 0.12 Ϫ0.37 0.56 SERPINF1 A_23_P100662 0.4929 0.17 Ϫ0.32 0.59 SERPINF1 NM_002615_1_1081 0.6121 0.13 Ϫ0.36 0.56 SPINK5 A_23_P10251 0.8944 0.03 Ϫ0.44 0.49 SPINK5 A_23_P356494 0.8385 Ϫ0.05 Ϫ0.51 0.43 STAB1 A_23_P32499 0.3960 0.21 Ϫ0.28 0.62 STAB1 A_23_P32500 0.5052 0.17 Ϫ0.32 0.59 STAB1 A_23_P32501 0.4565 0.19 Ϫ0.31 0.60 STAB1 A_24_P119456 0.7907 Ϫ0.07 Ϫ0.52 0.41 THBS1 A_23_P206210 0.4032 0.21 Ϫ0.28 0.62 THBS1 A_23_P206212 0.3615 0.23 Ϫ0.27 0.63 THBS1 A_32_P17173 0.2985 0.26 Ϫ0.24 0.65 THBS1 A_32_P17182 0.5937 0.13 Ϫ0.35 0.57 THBS2 A_23_P253651 0.2523 0.28 Ϫ0.21 0.66 THBS2 A_23_P253652 0.3260 0.25 Ϫ0.25 0.64 THBS2 A_23_P62021 0.3115 0.25 Ϫ0.24 0.64 THBS2* A_24_P605620 0.0330 0.50 0.05 0.79 THBS4 A_23_P250362 0.5568 0.15 Ϫ0.34 0.58 THBS4 A_23_P250363 0.9785 Ϫ0.01 Ϫ0.47 0.46 (Continued)

T20 ͉ AJNR ͉͉www.ajnr.org On-line Table 4: Continued Gene ID Reporter_ID P-value Estimate Lower Upper THBS4 A_24_P260443 0.9714 0.01 Ϫ0.46 0.47 TIE1 A_23_P126413 0.2765 0.27 Ϫ0.22 0.66 TIE1* A_23_P126416 0.0217 0.54 0.09 0.80 TIE1** A_23_P126422 0.0516 0.47 0.00 0.77 UNC5B A_23_P52336 0.2663 0.28 Ϫ0.22 0.66 UNC5B A_23_P52337 0.2186 0.30 Ϫ0.19 0.68 VASH1 A_23_P76998 0.4809 0.18 Ϫ0.32 0.60 VASH1 A_23_P77000 0.6325 0.12 Ϫ0.37 0.56 VASH1 A_23_P77002 0.5374 0.16 Ϫ0.34 0.58 VASH1 A_24_P304628 0.8524 Ϫ0.05 Ϫ0.50 0.43 VASH1 A_24_P304629 0.9311 0.02 Ϫ0.45 0.48 WISP3 A_23_P81676 0.9960 0.00 Ϫ0.47 0.47 * Indicates positive association P Ͻ 0.05; ** positive association 0.5 Ͻ P Ͻ 0.1; † negative association P Ͻ 0.05; †† negative association 0.5 Ͻ P Ͻ 0.1.

On-line Table 5: Correlation of genes with PS estimates and details of and function Signif. Abs. Max. Probes Corr. Coef. Association/Gene P Ͻ .05 (P Value) Details Negative with tumor permeability VASH2 1/2 Ϫ0.71 (.0011) Angiogenesis inhibitor;16 vasohibin-1 is expressed in endothelial cells in the termination zone to halt angiogenesis, whereas vasohibin-2 is expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis17 WNT5A 1/5 Ϫ0.52 (.0284) WNT5A, a member of the WNT family of signaling , is associated with the WNT/Ca(ϩϩ) pathway; promotes angiogenesis with induction of MMP1 and TIE2;18 inhibits angiogenesis and may play a role in migration and infiltration in glioma19,20 CX3CR1 1/4 Ϫ0.49 (.0375) CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1; increased expression of CXC3L1 is found in the most severe forms of gliomas21 Positive with tumor permeability PTPRM 4/4 0.82 (3.4 ϫ 10Ϫ5) Signaling molecule that regulates a variety of cellular processes; may be related to tight junctions in endothelial cells22 HIF1A 3/3 0.62 (.0065) Mediates the effects of hypoxia; promotes the formation of blood vessels23 KDR (VEGFR2) 5/5 0.59 (.0097) Functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting; KDR is prominently expressed in the polarized extension of tip cell filopodia, enabling migration along the chemoattractant gradient24 CDH5 1/4 0.56 (.0168) VE-cadherin/CDH5 plays a role in tumor-associated angiogenesis25 TNFRSF1A 2/5 0.53 (.0239) Members of the TNF ligand superfamily and their cognate receptors regulate various cellular responses, including proliferation, migration, differentiation, and apoptosis; TNF contributes to inflammation-associated angiogenesis26 TIE1 1/3 0.49 (.0389) VEGF activates the TIE family of receptor tyrosine kinases27 ADAMTS1 3/5 0.48 (.0436) Angiogenesis inhibitor; however, VEGF significantly induces ADAMTS1 expression in endothelial cells and thus may represent a mechanism for feedback of angiogenesis inhibition28 Single probe not consistent with other probes CCR3 1/3 Ϫ0.56 (.0155) It belongs to family 1 of the G -coupled receptors; increased expression of the CCL3L1, CCR3, and CCR5 chemokine-receptors system is involved in brain tumorigenesis, especially in the progression of GBM;29 results not matching AMOT 1/5 Ϫ0.51 (.0304) Receptor for the angiogenesis inhibitor angiostatin, regulates endothelial cell migration and tube formation (angiomotin regulates endothelial cell-cell junctions);30 negative regulation of angiogenesis; negative regulation of permeability NF1 1/3 Ϫ0.47 (.0469) It probably has antiangiogenic activity as evidenced by increased expression of proangiogenic factors and decreased expression of antiangiogenic factors in neurofibromin-deficient Schwann cells; NF1 deletion in mesenchymal subtype of GBM4 CX3CL1 1/8 0.48 (.0416) CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1, increased expression of CXC3L1 is found in the most severe forms of gliomas21 CD36 1/7 0.48 (.0469) Serves as a receptor for THBS1, is a potent inhibitor of angiogenesis31 PML 1/10 0.50 (.0334) Angiogenesis inhibitor; PML inhibits HIF-1␣ translation and neoangiogenesis through repression of mTOR;32 results not matching GATA4 1/3 0.51 (.0288) Regulates genes involved in embryogenesis and in myocardial differentiation and function; GATA factors promote vasculogenesis via activation of downstream targets33 THBS4 1/3 0.51 (.0324) A member of the thrombospondin protein family. KLK3 (PSA) 1/7 0.54 (.0221) KLK3 has antiangiogenic properties34 Note:—Abs. Max. Corr. Coef. indicates absolute maximum correlation coefficient; Signif., significant; mTOR, mammalian target of rapamycin; ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif; AMOT, angiomotin; CCR3, chemokine (C-C motif) receptor 3; CD36, CD36 molecule (thrombospondin receptor); CDH5, cadherin 5; CX3CL1, chemokine (C-X3-C motif) ligand 1; CX3CR1, chemokine (C-X3-C motif) receptor 1; GATA4, GATA binding protein 4; HIF1A, hypoxia inducible factor 1 alpha; KDR (VEGFR2), kinase insert domain receptor (vascular endothelial growth factor receptor); KLK3 (PSA), kallikrein-related peptidase 3 (prostate specific antigen); NF1, neurofibromin 1; PML, promyelocytic leukemia; PTPRM, protein tyrosine phosphatase, receptor type, M; TIE1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1; THBS1, thrombospondin 1; THBS4, thrombospondin 4; TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A; VASH2, vasohibin 2; WNT5A, wingless-type MMTV integration site family, member 5A.

AJNR Am J Neuroradiol ͉͉www.ajnr.org T21 On-line Table 6: Correlation of genes with CBV estimates and details of gene expression and function Signif. Abs. Max. Probes Corr. Coef. Association/Gene P Ͻ .05 (P value) Details Negative with tumor blood volume CX3CR1 3/4 Ϫ0.66 (.0028) CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1; increased expression of CXC3L1 is found in the most severe forms of gliomas21 C3 6/6 Ϫ0.63 (.0051) Complement component C3 plays a central role in the activation of complement system; complement-mediated inhibition of neovascularization35 IL1A 4/4 Ϫ0.55 (.0187) IL-1 family consists of pleiotropic proinflammatory and immunoregulatory cytokines, namely, IL-1␣ and IL-1␤36 Positive with tumor blood volume CD36 5/7 0.61 (.0073) Serves as a receptor for THBS1, is a potent inhibitor of angiogenesis;31 KDR (VEGFR-2) 2/5 0.60 (.0084) Functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting; KDR is prominently expressed in the polarized extension of tip cell filopodia, enabling migration along the chemoattractant gradient24 TEK/TIE2 3/4 0.58 (.0119) TEK receptor tyrosine kinase is expressed in endothelial cells and is also known as TIE2; it, along with angiopoietins, has a role in VEGF-induced angiogenesis37; angiopoietin/TIE2 signaling can also aid in recruitment of pericytes38 TIE1 1/3 0.54 (.0217) VEGF activates the TIE family of receptor tyrosine kinases27 PTPRM 1/4 0.47 (.0495) Signaling molecule that regulates a variety of cellular processes; may be related to tight junctions in endothelial cells22 Single probe not consistent with other probes THBS2 1/4 0.50 (.0330) Potent inhibitor of tumor growth and angiogenesis39 Note:—Abs. Max. Corr Coef. indicates absolute maximum correlation coefficient; Signif., significant; CX3CR1, chemokine (C-X3-C motif) receptor 1; C3, complement component 3; IL1A, interleukin 1, alpha; CD36, CD36 molecule (thrombospondin receptor); KDR (VEGFR2), kinase insert domain receptor (vascular endothelial growth factor receptor); PTPRM, protein tyrosine phosphatase, receptor type, M; TEK/TIE2, tyrosine kinase, endothelial/endothelium-specific receptor tyrosine kinase 2; THBS1, thrombospondin 1; THBS2, thrombospondin 2; TIE1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1.

T22 ͉ AJNR ͉͉www.ajnr.org