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University International INFORMATION TO USERS This was produced from a copy of a document sent to us for microfilming. While the most advanced technological means to photograph and reproduce this document have been used, the quality is heavily dependent upon the quality of the material submitted. The following explanation of techniques is provided to help you understand markings or notations which may appear on this reproduction. 1. The sign or “target” for pages apparently lacking from the document photographed is “Missing Page(s)”. If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages. This may have necessitated cutting through an image and duplicating adjacent pages to assure you of complete continuity. 2. When an image on the film is obliterated with a round black mark it is an indication that the film inspector noticed either blurred copy because of movement during exposure, or duplicate copy. Unless we meant to delete copyrighted materials that should not have been filmed, you will find a good image of the page in the adjacent frame. If copyrighted materials were deleted you will find a target note listing the pages in the adjacent frame. 3. When a map, drawing or chart, etc., is part of the material being photo­ graphed the photographer has followed a definite method in “sectioning” the material. It is customary to begin filming at the upper left hand corner of a large sheet and to continue from left to right in equal sections with small overlaps. If necessary, sectioning is continued again—beginning below the first row and continuing on until complete. 4. For any illustrations that cannot be reproduced satisfactorily by xerography, photographic prints can be purchased at additional cost and tipped into your xerographic copy. Requests can be made to our Dissertations Customer Services Department. 5. Some pages in any document may have indistinct print. In all cases we have filmed the best available copy. University MicrxSilms International 300 N. ZEEB RD., ANN ARBOR. Ml 48106 8128990 D iT ir r o, F r a n k Je r a u l d IMMUNOHISTOCHEMICAL STUDIES OF SPINAL PEPTIDE AND SEROTONIN ELEMENTS IN THE NORTH AMERICAN OPOSSUM, DIDELPHIS VIRGINIAN A. I. THE DISTRIBUTION OF SOMATOSTATIN, METHIONINE-ENKEPHALIN AND SEROTONIN IMMUNOREACTIVITIES IN THE SPINAL CORD OF THE ADULT OPOSSUM. II. THE ONTOGENY OF SPINAL PEPTIDERGIC AND SEROTONINERGIC IMMUNOREACTIVE ELEMENTS IN THE OPOSSUM. The Ohio State University Ph.D. 1981 University Microfilms International300 N. Zeeb Road, Ann Arbor, MI 48106 PLEASE NOTE: In all cases this material has been filmed in the best possible way from the available copy. Problems encountered with this document have been identified here with a check mark V ■ 1. Glossy photographs or pages ^ 2. Colored illustrations, paper or print_____ 3. Photographs with dark background 4. Illustrations are poor copy______ 5. Pages with black marks, not original copy______ 6. Print shows through as there is text on both sides of page______ 7. Indistinct, broken or small print on several pages __ 8. Print exceeds margin requirements_____ 9. Tightly bound copy with print lost in spine______ 10. Computer printout pages with indistinct print ______ 11. Page(s) ___________ lacking when material received, and not available from school or author. 12. Page(s) ___________ seem to be missing in numbering only a s text follows. 13. Two pages num bered ___________ . Text follows. 14. Curling and wrinkled pages______ 15. Other______________________________________________________________________ University Microfilms International IMMUNOHISTOCHEMICAL STUDIES OF SPINAL PEPTIDE AND SEROTONIN ELEMENTS IN THE NORTH AMERICAN OPOSSUM, Didelphis virginiana. I. THE DISTRIBUTION OF SOMATOSTATIN, METHIONINE-ENKEPHALIN AND SEROTONIN IMMUNOREACTIVITIES IN THE SPINAL CORD OF THE ADULT OPOSSUM. II. THE ONTOGENY OF SPINAL PEPTIDERGIC AND SEROTONINERGIC IMMUNOREACTIVE ELEMENTS IN THE OPOSSUM. DISSERTATION Presented in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the Graduate School of The Ohio State University By Frank Jerauld DiTirro, B.S., M.Sc. ****** The Ohio State University 1981 Reading Committee: Approved By Raymond H. Ho, Ph.D., Adviser George F. Martin, Ph.D., Adviser Albert 0. Humbertson, Jr., Ph.D. Advisers Department of Anatomy Dedicated to my best friends, Ellen, Fred and Fran. ii ACKNOWLEDGEMENTS The author wishes to sincerely thank Dr. Raymond H. Ho for his continual concern and support, but most of all, for his compassion expressed in his professional and personal guidance. He also wishes to thank Dr. George F. Martin for an inexhaustable source of motivation, knowledge and for his literary expertise. To Drs. Raymond H. Ho and Robert P. Elde who provided a seemingly endless supply of antisera, he is indebted. The author expresses his deep appreciation for aid, advice and the camraderie provided him by Mr. Karl B. Rubin. Thanks also go out to Ms. Malinda E. Amspaugh for the typing of the manuscript. Finally, to the faculty, staff and students of the Department of Anatomy, especially Dr. James S. King, many thanks for making his graduate experience, an experience. iil VITA NAME: Frank Jerauld DiTirro BORN: December 12, 1953 PLACE OF BIRTH: Cleveland, Ohio EDUCATION: Grade School and High School Council Rock Elementary School - 1958-1963 Brighton Junior High School - 1963-1967 Brighton High School - 1967-1971 Rochester, New York 14618 Colleges and Degrees Denison University (1971-1975) Granville, Ohio B.S., Biology Ohio State University (1975-1977) Columbus, Ohio Post-Baccalaureate Studies, Continuing Education Ohio State University (1977-1979) Columbus, Ohio Department of Anatomy, M.S. Ohio State University (1979-present) Columbus, Ohio, Department of Anatomy, Ph.D. Candidate TEACHING EXPERIENCE: Graduate Teaching Associate - Gross Anatomy to Allied Medical School Students - Autumn 1977, Winter and Spring 1978, Spring 1979, Winter, Spring and Autumn 1980, Winter and Spring 1981. Graduate Teaching Associate - Dental Anatomy, Gross Anatomy, Histology and Neuroanatomy - Summer and Autumn 1978, Winter 1979. Graduate Teaching Associate - Medical School, Gross Anatomy, Histology and Neuroanatomy - Summer and Autumn 1979. Graduate Teaching Associate - Graduate Gross Anatomy, Autumn 1980. SCIENTIFIC SOCIETIES: Society for Neuroscience iv OFFICES AND COMMITTEES: Association of Anatomy Graduate Students President (1978-1979) Curriculum Committee (1979-1980) Departmental Self-Study Committee (1979-1980) PUBLICATIONS DiTirro, F.J., R. Ho and G.F. Martin 1979 Substance-P (SP) immuno- reactivity in the spinal cord of the North American opossum. Anat. Rec., 193: 525 (abstract). DiTirro, F.J., R.H. Ho and G.F. Martin 1979 Substance-P, somato­ statin and methionine-enkephalin immunoreactivity in the spinal cord of the North American opossum. Neurosci. Abstr., 5: 2431. DiTirro, F.J. and R.H. Ho 1980 Distribution of substance-P (SP), somatostatin (SOM) and methionine-enkephalin (ENK) in the spinal cord of the domestic rabbit. Anat. Rec., 196: 47A (abstract). DiTirro, F.J., R.H. Ho and G.F. Martin 1980 Serotonin (5-HT) immuno­ reactivity in the spinal cord of the North American opossum, Didelphis virginiana. Neurosci. Abstr., 10: 383. Ho, R.H., A.L. LaValley and F.J. DiTirro 1980 Preliminary studies of 5-hydroxytryptamine-like immunoreactivity in the spinal cord of the domestic fowl. Neurosci. Abstr., 10: 382. Martin, G.F., T. Cabana, F.J. DiTirro, R.H. Ho and A.0. Humbertson, Jr. 1981 Evidence for heterogeneity in the raphe-spinal projections of the North American opossum. Anat. Rec., 199: 161 (abstract). Cabana, T., F.J. DiTirro, R.H. Ho and G.F. Martin 1981 The develop­ ment of serotoninergic pathways within the spinal cord. Studies using the North American opossum as an experimental model. Neurosci. Abstr., 11. Full papers DiTirro, F.J., R.H. Ho and G.F. Martin 1981 Immunohistochemical localization of substance-P, somatostatin and methionine-enkephalin in the spinal cord and dorsal root ganglia of the North American opossum, Didelphis virginiana. J. Comp. Neur., 198: 351-363. v Martin, G.F., T. Cabana, F.J. DiTirro, R.H. Ho and A.O. Humbertson, Jr. 1981 The organization and development of spinal projections from reticular, raphe and rubral neurons and their control by the motor cortex. In: J.E. Desmedt (ed.) Motor Control in Man: Mechanisms and Clinical Applications. Raven Press (in press). Martin, G.F., T. Cabana, F.J. DiTirro, R.H. Ho and A.O. Humbertson, Jr. 1981 The development of descending spinal connections. Studies using the North American opossum. In: H.G.J.M. Kuypers and G.F. Martin (eds.) Progress in Brain Research series on Descending Spinal Control, Elsevier Press, Amsterdam. Martin, G.F., T. Cabana, F.J. DiTirro, R.H. Ho and A.O. Humbertson, Jr. 1981 Reticular and raphe projections to the spinal cord of the North American opossum. Evidence for connectional heterogeneity. In: H.G.J.M. Kuypers and G.F. Martin (eds.) Progress in Brain Research series on Descending Spinal Control, Elsevier Press, Amsterdam. PRESENTATIONS Substance-P (SP) immunoreactivity in the spinal cord of the North American opossum. Ninety-second Annual Session of American Association of Anatomists, Miami, Florida, 1979. Substance-P, somatostatin and methionine-enkephalin immunoreactivity in the spinal cord of the North American opossum. Ninth Annual Meeting, Society for Neuroscience, Atlanta, Georgia, 1979. Distribution of substance-P (SP), somatostatin (SOM) and methionine- enkephalin (ENK) in the
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