bioRxiv preprint doi: https://doi.org/10.1101/2020.06.21.163857; this version posted June 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Non-canonical immune response to the inhibition of DNA methylation via stabilization of endogenous retrovirus dsRNAs Yongsuk Ku1,6, Joo-Hwan Park2,3,6, Ryeongeun Cho1,6, Yongki Lee1, Hyoung-Min Park4, MinA Kim1, Kyunghoon Hur1, Soo Young Byun5, Jun Liu2,3, David Shum5, Dong-Yeop Shin2,3, Youngil Koh2,3, Je-Yoel Cho4, Sung-Soo Yoon2,3, Junshik Hong2,3*, Yoosik Kim1* 1Department of Chemical and Biomolecular Engineering and KAIST Institute for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea 3Cancer Research Institute, Seoul National University Hospital, Seoul, Korea 4Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul, Korea 5Screening Discovery Platform, Translation Research Division, Institut Pasteur Korea, Seongnam, Gyeonggi, Korea. 6These authors contributed equally *To whom correspondence should be addressed:
[email protected] (Y.K). Correspondence may also be addressed to:
[email protected] (J. H). 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.06.21.163857; this version posted June 21, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission.