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Official Journal of the American College of Sports Medicine Vol. 51 No. 5 Supplement S1 A-17 Thematic Poster - Acute Exercise cerebral blood flow velocity (p<0.01). Cerebrovascular regulation parameters were not associated with white matter lesions (p>0.468). We observed a significant association Wednesday, May 29, 2019, 9:30 AM - 11:30 AM between cerebrovascular regulation parameters and language processing (p=0.010) Room: CC-102A but not other cognitive domains. Conclusion: In cognitively normal older adults, higher ASCVD risk score was associated with blunted cerebrovascular regulation and with lower language 60 Chair: Juan Murias. University of Calgary, AB, Canada. processing performance. These results highlight the need for CVD risk management to maintain optimal brain health. (No relevant relationships reported) 61 Board #1 May 29 9:30 AM - 11:30 AM Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Autonomic Modulation Yu Lun Tai1, Erica M. Marshall2, Jason C. Parks2, J. Derek Kingsley, FACSM2. 1University of Texas Rio Grande Valley, Brownsville, TX. 2Kent State University, Kent, OH. (Sponsor: Dr. J. Derek Kingsley, FACSM) Email: [email protected] (No relevant relationships reported) WEDNESDAY, MAY 29, 2019 29, MAY WEDNESDAY, While data have demonstrated that resistance exercise without blood flow restriction (BFR) decreases vagal tone up to 30 minutes, the effects of upper- versus lower-body resistance exercise with BFR on autonomic modulation are unknown.PURPOSE: To evaluate autonomic modulation in response to upper- and lower-body resistance exercise with BFR. METHODS: Autonomic modulation was assessed in twenty resistance-trained individuals at rest, 30 (R30), and 60 (R60) minutes after either upper- or lower-body resistance exercise with or without BFR. The upper- and lower- body resistance exercise consisted of the lat pulldown and chest press, and knee extension and knee flexion, respectively. The BFR (40% of arterial occlusion pressure) and without BFR conditions consisted of 4 sets of 30, 15, 15, and 15 repetitions at 30% 1-repetition maximum (1RM), and 4 sets of 8 repetitions at 70% 1RM, respectively. Autonomic modulation was expressed as natural logarithm (Ln), and included total power (LnTP), high frequency power (LnHF), and sympathovagal balance (LnLF/ LnHF ratio). An ANOVA was used to evaluate groups (upper- or lower-body) across conditions (BFR or without BFR) across time (Rest, R30, and R60) on autonomic modulation. RESULTS: There were no significant 3-way interactions for any variables. There were no changes for LnTP. There were significant main effects of time for LnHF (Upper-body with BFR (UBFR): Rest: 7.3±1.6ms2, R30: 6.3±1.6ms2, R60: 6.7±1.5ms2; Upper-body without BFR (UW): Rest: 7.1±1.4ms2, R30: 6.1±1.5ms2, R60: 6.5±1.3ms2; Lower-body with BFR (LBFR): Rest: 6.9±1.3ms2, R30: 6.2±1.6ms2, R60: 7.1±1.4ms2; Lower-body without BFR (LW): Rest: 7.3±1.5ms2, R30: 6.3±1.8ms2, R60: 7.1±1.4ms2) and the LnLF/LnHF ratio (UBFR: Rest: 3.9±0.9ms2, R30: 5.1±10.9ms2, R60: 4.8±1.0ms2; UW: Rest: 3.7±1.0ms2, R30: 4.9±0.8ms2, R60: 4.8±0.7ms2; LBFR: Rest: 4.0±1.0ms2, R30: 4.8±1.1ms2, R60: 4.5±1.0ms2; LW: Rest: 3.9±1.0ms2, R30: 5.0±0.9ms2, R60: 4.65±0.84ms2) such that LnHF and LnLF/HF ratio were significantly reduced, and augmented, after upper- and lower-body resistance exercise with and without BFR. CONCLUSIONS: These data suggest that either upper- or lower-body 63 Board #3 May 29 9:30 AM - 11:30 AM resistance exercise with or without BFR significantly alters autonomic modulation up to 60 minutes after an acute bout of resistance exercise. Looking Beyond A-vo2 Difference: Peripheral Adaptations And Vo2Max In Trained And Untrained 62 Board #2 May 29 9:30 AM - 11:30 AM Adults Cardiovascular Disease Risk Influences Jayson R. Gifford1, Ryan Garten2, Joshua Weavil3, Ryan 3 3 3 1 Cerebrovascular Regulation in Older Adults Broxterman , Joel Trinity , Russell Richardson . Brigham 2 1 1 1 2 Young University, Brigham Young University, UT. Virginia Sophy J. Perdomo , Jaimie Ward , Yumei Liu , Eric D. Vidoni , Commonwealth University, Richmond, VA. 3University of Utah, Emily Witte1, Jason F. Sisante1, Kiersten Kirkendoll1, Jeffrey 2 1 1 Salt Lake City, UT. Burns , Sandra A. Billinger . University of Kansas Medical Email: [email protected] Center, Kansas City, KS. 2University of Kansas Alzheimer’s Disease Center, Fairway, KS. (No relevant relationships reported) Email: [email protected] PURPOSE: Observing little-to-no increase in arterial-venous oxygen difference (No relevant relationships reported) (a-vO2diff) following endurance training, some previous investigations have attributed little importance to factors peripheral to the heart, such as maximal mitochondrial Purpose: The aim of this study was to evaluate the influence of CVD on oxygen consumption (MitoVO2max) and convective (QmO2) and diffusive (DmO2) cerebrovascular regulation at rest and during exercise. A secondary aim was to muscle oxygen delivery in the training-induced increase in VO max. As lack of change explore the relationship between cerebrovascular regulation and 1) the presence of 2 in a-vO2diff does not necessarily indicate a lack of change in peripheral function, white matter lesions and 2) cognitive function. the purpose of this study was to determine the combined influences of adaptations Methods: We recruited individuals who were cognitively normal older adults. CVD peripheral to the heart in the endurance-training-associated increase in VO2max. risk METHODS: Arterial-venous blood draws and Doppler ultrasound during maximal was assessed by the Pooled Cohort atherosclerotic cardiovascular disease (ASCVD) single leg knee extension (KE) exercise were used to quantify Q O , D O a-vO diff risk score. Transcranial Doppler ultrasound measured middle cerebral artery at rest m 2 m 2, 2 and KEVO2max when free of upstream limitations from the heart in 10 untrained and and during a bout of moderate intensity exercise. We quantified white matter lesions 10 trained young males. Mitochondrial respiration of muscle biopsied from the vastus from MRI and cognitive function outcomes included executive function, language, lateralis was used to quantify MitoVO2max when free from upstream oxygen supply processing speed, and attention. limitations. Summary of Results: Seventy-two participants 70.1 ± 4.7 years of age completed the RESULTS: In agreement with previous investigations, Q O and VO max were study m 2 KE 2 20-35% greater in the trained (P<0.05), while a-vO2diff was not markedly different protocol. ASCVD risk score was significantly associated with both resting and exercise (P>0.05, See Figures A-C). Nevertheless, training was associated with a 50-100% Abstracts were prepared by the authors and printed as submitted. ® S2 Vol. 51 No. 5 Supplement MEDICINE & SCIENCE IN SPORTS & EXERCISE increases in DmO2 and MitoVO2max, (P<0.05). When plotted as a Wagner diagram 65 Board #5 May 29 9:30 AM - 11:30 AM (Figure D), it becomes clear that the greater VO max in the trained is the result of 3 KE 2 Effects Of Matched Intermittent Versus Continuous synergistic adaptations (1. increased VO max, 2. increased Q O and 3. enhanced Mito 2 m 2 Exercises On The Changes Of Cardiac Biomarkers DmO2), which, together, raise VO2max more than each adaptation would alone. Feifei LI1, Will Hopkins2, Nie Jinlei3, Longyan Yi4. 1Hebei CONCLUSIONS: Despite minimal changes in a-vO2diff, the training-associated 2 increase in KEVO2max is dependent upon specific peripheral factors within the muscle Normal University, Shijiazhuang, China. Victoria University, exhibiting a greater capacity, including mitochondrial respiratory capacity, as well as Melbourne, Australia. 3Macao Polytechnic Institute, Macao, convective and diffusive muscle oxygen delivery. China. 4Beijing Sport Univeristy, Beijing, China. Email: [email protected] (No relevant relationships reported) PURPOSE: Endurance runners training with high-intensity intermittent exercise might experience damage to cardiac muscle. We have therefore compared the changes of cardiac biomarkers after workload-matched intermittent and continuous exercise in such runners. METHODS: Twelve endurance runners (11 males, 1 female; age, 23.5±5.5 y; VO2max, −1 −1 −1 62.4±5.4 ml.kg .min ; velocity of VO2max [vVO2max], 17.1±1.4 km.h ; training volume, 44 ± 25 km.wk−1) completed intermittent and continuous exercise trials in random order. Intermittent exercise consisted of hard running at 90% vVO2max for 2 min followed by easy running at 50% vVO2max for 2 min, repeated for 92 min in total. The continuous run was performed at 70% vVO2max for 92 min. Blood samples were drawn before exercise and at 0, 2, 4, 24 and 48 h after the completion of exercise for assay of various cardiac biomarkers. Changes in concentration of each biomarker were averaged over 0-24 h for comparison of intermittent with continuous exercise after adjustment for baseline concentration and exercise intensity expressed as percent of heart-rate reserve (%HRR). RESULTS: There were trivial differences between the changes in concentration adjusted to the mean intensity of 78%HRR for all biomarkers investigated, but at 85%HRR high-sensitivity cardiac troponin-I and high-sensitivity cardiac troponin-T were moderately higher following intermittent exercise (factor mean change ×/÷90% confidence limits: 3.4 ×/÷1.9 and 2.1 ×/÷1.8 respectively). Changes in other cardiac biomarkers at 85%HRR were trivial. CONCLUSIONS: Prolonged intermittent exercise is potentially more damaging to 64 Board #4 May 29 9:30 AM - 11:30 AM heart muscle than continuous exercise of the same average running speed at higher average heart rates. Autonomic Modulation After High-Intensity Heavy Rope Exercise in Resistance-trained Individuals 66 Board #6 May 29 9:30 AM - 11:30 AM WEDNESDAY, MAY 29, 2019 29, MAY WEDNESDAY, Erica M.