Hematolymphoid-System.Pdf
Toxicologic Pathology 2019, Vol. 47(6) 665-783 ª The Author(s) 2019 Nonproliferative and Proliferative Article reuse guidelines: sagepub.com/journals-permissions Lesions of the Rat and Mouse DOI: 10.1177/0192623319867053 journals.sagepub.com/home/tpx Hematolymphoid System 1 2,c Cynthia L. Willard-Mack, (Chair) , Susan A. Elmore , 3 4,e,g 5,f William C. Hall , Johannes Harleman , C. Frieke Kuper , 6,a 7,d,g 8,g Patricia Losco , Jerold E. Rehg , Christine Ru¨ hl-Fehlert , 9,d,g 10,b 11 Jerrold M. Ward , Daniel Weinstock , Alys Bradley , 12 13 14 Satoru Hosokawa , Gail Pearse , Beth W. Mahler , 2 15 Ronald A. Herbert , and Charlotte M. Keenan Abstract The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative changes in rats and mice. The purpose of this publication is to provide a standardized nomenclature for classifying changes observed in the hematolymphoid organs, including the bone marrow, thymus, spleen, lymph nodes, mucosa-associated lymphoid tissues, and other lymphoid tissues (serosa-associated lymphoid clusters and tertiary lymphoid structures) with color photomicrographs illustrating examples of the lesions. Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. The nomenclature for these organs is divided into 3 terminologies: descriptive, conventional, and enhanced.
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