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University of Bradford eThesis This thesis is hosted in Bradford Scholars – The University of Bradford Open Access repository. Visit the repository for full metadata or to contact the repository team © University of Bradford. This work is licenced for reuse under a Creative Commons Licence. Ocular Biometric Change in Orthokeratology An investigation into the effects of orthokeratology on ocular biometry and refractive error in an adult population Annette PARKINSON Submitted for the degree of Doctor of Philosophy Bradford School of Optometry and Vision Science 2012 Annette Parkinson Title: Ocular Biometric Change in Orthokeratology Keywords: Orthokeratology, Ocular Biometry, Corneal Topography, Refractive error ABSTRACT Aim; This study looks at the effect of orthokeratology on a number of biometric parameters and refractive error in an adult population. Method; Forty three myopic subjects were recruited to a twelve month study into the effects of orthokeratology on ocular biometry and refractive error. Two different back surface lens designs were applied right eye) pentacurve and left eye) aspheric. The aspheric design was chosen to more closely mimic the cornea’s natural shape. Anterior and posterior apical radii and p-values; corneal thickness and anterior chamber depth were measured using the Orbscan IIz; together with ocular biometry by IOL Master and a standard clinical refraction. All measurements were repeated at one night, one week, one, three, six and twelve months. Refractive changes were analysed against biometric changes. Results; Twenty seven participants completed one month of lens wear. Twelve subjects completed twelve months of lens wear. Subjects with myopia ≤ -4.00DS were successfully treated with orthokeratology. Both anterior and posterior apical radii and p values were altered by orthokeratology. Corneal thickness changes were in agreement with previously published studies. Axial length and anterior chamber depth were unaffected by the treatment. Conclusion; Orthokeratology should be available as an alternative to laser refractive surgery. It is best restricted to myopes of up to -4.00DS with low levels of with the rule corneal astigmatism. The use of an aspheric back design contact lens did not produce a significant benefit over that of a pentacurve. i Acknowledgements I am indebted to my three supervisors for their support throughout the period of this study; Professor W.A.Douthwaite for his initial guidance and inspiration at the outset, Dr E.A.H. Mallen for his constant support, advice and guidance throughout the study, and Dr J.M. Gilchrist for stepping in to assist in the latter stages following Professor Douthwaite’s retirement. I am grateful to No 7 Contact Lenses for providing all the lenses used in the study. I would like to acknowledge those participants who took part in this longitudinal study, particularly for their willingness to attend the early morning measurement sessions. I would like to thank all my colleagues at the Bradford School of Optometry and Vision Science, particularly Ms Catherine Viner, for their enthusiastic encouragement. Lastly I would like to thank my family for their support. ii CONTENTS Chapter 1 Introduction 1 1.1 Historical Perspective 1.1.1 The Berkeley Orthokeratology Study 1.1.2 The Tabb Method 1.2 Reverse Geometry lenses (circa 1989) 19 1.3 Overnight wear of lenses 23 1.4 Corneal Changes associated with Orthokeratology 24 1.5 Predicting success with Orthokeratology 28 1.6 Mathematical Model of the cornea 30 1.7 Axial edge lift in contact lens design 39 1.8 Retention and Regression 41 1.9 Corneal Biomechanics and Mechanisms of Orthokeratology 43 1.10 Comparative Lens design studies in orthokeratology 46 1.11 Control of Myopia with Orthokeratology 49 1.12 Complications associated with Orthokeratology 51 1.12.1 Corneal staining 1.12.2 Microbial Keratitis 1.12.3 Iron ring deposition in orthokeratology 1.12.4 Other corneal events 1.13 Non Orthokeratology uses of reverse geometry lenses 66 1.13.1 Trauma 1.13.2 Post operative complications of Refractive surgery 1.13.3 Post operative management of corneal grafts iii 1.14 Summary 67 1.15 Study rationale and aims 71 Chapter 2 Preliminary Studies 74 2.1 Measurement error and repeatability 76 2.2 The Orbscan II 80 2.2.1 Introduction 2.2.2 Image production 2.2.3 Pachymetry 2.3 Previous Orbscan repeatability studies 90 2.4 Orbscan Repeatability 94 2.4.1 Anterior repeatability on corneas 2.4.1.1 Method 2.4.2 Posterior repeatability on corneas 2.4.2.1 Method 2.4.3 Posterior repeatability using test surfaces 2.4.3.1 Method 2.5 Orbscan Repeatability Results 100 2.5.1 Anterior 2.5.1.1 Global 2.5.1.2 Single meridian 2.5.2 Posterior cornea 2.5.2.1 Global 2.5.2.2 Single meridian 2.5.3 Posterior surfaces 2.6 Orbscan Discussion 122 2.6.1 Anterior cornea 2.6.2 Posterior cornea iv 2.6.3 Posterior surfaces 2.7 Study limitations 126 2.8 The EyeSys Corneal Analysis System (2000) 127 2.8.1 Introduction 2.9 Method 131 2.9.1 Image capture 2.9.2 Analysis 2.10 Results Comparison of Orbscan and EyeSys apical radius and p value 134 2.11 Discussion 140 2.12 The IOL Master 141 2.12.1 Introduction 2.13 IOL Master Method 144 2.13.1 Axial length measurements 2.13.2 Anterior chamber depth measurements method 2.14 Collar and Pillar 147 2.14.1 Introduction 2.15 Calculation of Pillar diameters 148 2.15.1 Method 2.15.2 BOZR measurements 2.15.3 Sag measurements 2.15.4 Measurement of lens sag for an unknown lens 2.15.5 Example of calculation of sag for comparison with the three pillar diameters used for verification purposes 2.15.6 Verification of orthokeratology lenses 2.16 Results 154 2.16.1 Pentacurve design 2.16.2 Aspheric design v 2.17 Discussion 163 Chapter 3 Protocols and Initial Outcomes 164 3.1 Introduction 164 3.2 Subject recruitment for orthokeratology study 165 3.3 Initial assessment 166 3.4 Power vectors (Thibos, Wheeler & Horner 1997) 169 3.5 Lens design appointment 171 3.6 Lens design protocols 173 3.6.1 C5 design 3.6.2 Aspheric design 3.7 Collection protocol 181 3.8 Protocol for first overnight visit 185 3.9 Study profiles 186 3.10 Statistical analysis 191 3.11 Power analysis (A priori) 191 Chapter 4 Anterior Corneal Response 193 4.1 Introduction 193 4.1.1 Anterior apical radius 4.1.2 Asphericity 4.1.3 Effect of orthokeratology on refractive error 4.1.4 Effect of orthokeratology on astigmatism 4.2 Anterior corneal response methods 203 4.2.1 Apical radius and p value change 4.2.2 Corneal sag change 4.2.3 Agreement between pentacurve BOZR and anterior apical radius of the right eye 4.2.4 Agreement between the aspheric lens sag and corneal sag of the left eye vi 4.2.5 Refractive error 4.2.6 Corneal power change 4.2.7 Anterior vertical cornea 4.2.8 VAR rating 4.2.9 Treatment zone diameter and decentration 4.2.10 Physiological response 4.3 Results 211 4.3.1 Anterior apical radius and p value 4.3.2 Corneal sag 4.3.3 Results for the pentacurve BOZR and right eye apical radius and the aspheric lens sag and left corneal sag 4.3.4 Results for corneal sag 4.3.5 Results for refractive error 4.3.6 Results for corneal power 4.3.7 Results for vertical cornea 4.3.8 Results for VAR 4.3.9 Results for the treatment zone 4.3.10 Results for the physiological response 4.4 Discussion 252 4.4.1 Apical radius and p value change 4.4.2 BOZR and apical radius and lens sag and corneal sag 4.4.3 The relationship between corneal power and refractive error in orthokeratology 4.4.4 Vertical cornea 4.4.5 Visual acuity and orthokeratology (VAR) results 4.4.6 Treatment zone and decentration 4.4.7 Physiological response 4.5 Conclusion 263 vii Chapter 5 Topography Posterior 264 5.1 Introduction 264 5.1.1 The effect of orthokeratology on the posterior cornea 5.2 Posterior surface 269 5.2.1 Method 5.2.2 Results 5.3 Discussion 273 Chapter 6 Corneal thickness response 274 6.1 Introduction 274 6.1.1 Introduction effect of orthokeratology on corneal thickness 6.1.2 Central corneal thickness measures by Orbscan 6.2 Repeatability of the initial corneal thickness measures 278 6.2.1 Method and data analysis 6.3 Change in corneal thickness at each visit for the twelve months of the study 279 6.3.1 Method and data analysis 6.4 Results 280 6.4.1 Repeatability of the initial corneal thickness measures 6.4.2 Results change in corneal thickness at each visit for the twelve months of the study 6.4 Discussion 289 viii Chapter 7 Anterior Chamber and Axial length effects of orthokeratology 294 7.1 Introduction 294 7.1.1Anterior chamber depth 7.1.2 Axial length 7.1.3 Axial length changes in orthokeratology 7.2 Anterior chamber and axial length measurements 302 7.2.1 Anterior chamber method 7.2.2 Axial length method 7.3 Results 303 7.4 Discussion 311 Chapter 8 Optical Modelling 312 8.1 Ocular aberrations and orthokeratology 8.1.1 Root mean square (RMS) 8.1.2 Zernike polynomials 8.1.3 Ocular component contributions to aberrations 8.2 Effect of orthokeratology on higher order ocular aberrations 8.3 The effect of orthokeratology on higher order ocular aberrations in the study group 323 8.3.1 Method 8.3.2 Results 8.4 Discussion 329 8.4.1 Interaction between biometric factors Chapter 9 Conclusions 333 9.1 Clinical considerations 9.2 Power analysis (Post Hoc) 9.3 Limitations of the current study 9.4 Future work References 345 ix Appendices 372 A.