Infantile Colic: a Critical Appraisal of the Literature from an Osteopathic Perspective
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International Journal of Osteopathic Medicine 9 (2006) 94e102 www.elsevier.com/locate/ijosm Review Infantile colic: A critical appraisal of the literature from an osteopathic perspective Kok Weng Lim* European School of Osteopathy/University of Greenwich, Boxley House, Boxley, Maidstone, Kent ME14 3DZ, UK Received 10 November 2005; received in revised form 18 June 2006; accepted 12 July 2006 Abstract The term infantile colic though often used is poorly understood. This common affliction of early infancy, in which crying is the primary symptom, has been the subject of numerous publications over many decades. This appraisal of the literature reveals that lack of consensus on the definition of colic poses difficulties when assessing the outcome and validity of research. In addition, the numerous hypotheses, reviewed here, on the precise cause of infantile colic have resulted in various approaches to treatment and no clear strategy for management. The possibility that mechanical factors play a role in the aetiology of colic underlies the osteopathic approach to treatment which, despite anecdotal success, is poorly documented. This article is designed to appraise osteopaths with an overview of the field to better inform their practice. Ó 2006 Published by Elsevier Ltd. Keywords: Osteopathy; Osteopathic medicine; Aetiology; Literature review 1. Introduction error approach that may compound the distress that is inevitably also suffered by the parents. Infantile colic is often described as a behavioural and This article is based on a review of the literature iden- non-pathological condition in early infancy with crying tified through searching online (Medline) and at aca- being the primary symptom. It is a poorly defined but demic libraries accessible to the author. It is written in common affliction of early infancy, the cause of which the hope that an appraisal of this field will better inform is still currently obscure and controversial and there is osteopathic practice. A historical overview of the subject therefore a lack of an appropriate strategy for the man- is beyond the scope of this paper. agement and treatment of this condition. This lack of a consensus on the aetiology of colic, in spite of over 1.1. Definition of infantile colic six decades of research, has resulted in various treatment approaches of dubious and varying merit, a trial and There is much debate as to what infantile colic actu- ally is. The term colic is derived from the Greek word kolikos, an adjective of kolon meaning the large intes- tine. The word colic suggests that the condition is a man- * St Stephens Practice, 21a St Stephens Road, Norwich NR1 3 SP. ifestation of some type of abdominal or visceral pain, Tel./fax: þ44 (0)1603 630 226. possibly intestinal cramps. This is contentious as the E-mail address: [email protected] implication that the crying of a colicky infant is a result 1746-0689/$ - see front matter Ó 2006 Published by Elsevier Ltd. doi:10.1016/j.ijosm.2006.07.001 K.W. Lim / International Journal of Osteopathic Medicine 9 (2006) 94e102 95 of the infant experiencing pain that is abdominal in crying has been carried out by various workers8e10 but origin is not necessarily true in all infants who cry.1 because of the different methods used to record crying The most universally accepted definition of colic and these results have varied. These studies reinforce the one which is most used in clinical research is that pro- point that crying is a normal developmental phenomenon posed by Wessel et al.,2 in a study involving 180 mothers and that what is termed colic may simply be the upper and their infants. The inclusion criterion for this study spectrum of a natural physiological and developmental was ‘‘paroxysms of irritability, fussing or crying lasting process or behavioural response in normal infants. That for a total of more than 3 h a day and occurring on is to say, colic may not necessarily be a disorder but the more than three days in any one week’’ in an infant extreme of normal early infant behaviour. who was otherwise ‘‘healthy and well fed’’. The study Brazelton’s (1962) work in which 80 mothers docu- stated that if an infant ‘‘had no such paroxysms or if mented their infants’ crying in a diary for 12 weeks is of- the paroxysms were less than the above in total duration ten cited as the referenced norm for crying.8 He reported he was classified as contented’’. There was therefore an that at two weeks of age, the median amount of crying arbitrary fixing of a threshold for colic in this study, was 1.75 h a day, at six weeks it was 2.75 h, decreasing which did not include infants who were mildly fussy. thereafter to less than 1 h by the 12th week. Interest- There is clearly a spectrum of severity of crying and ingly, twenty-five percent of the infants in his study cried the distinction between normal crying and crying that for at least 3.5 h a day at six weeks of age, thus falling signifies colic is unclear. A similar criterion was pro- within the Wessel’s2 definition of colicky crying. posed by Illingworth.3,4 A more recent study by St. James-Roberts and Variations of the above definition can be seen in the Halil10 also established a baseline standard for normal literature, such as a stipulation for crying for at least infant crying with the following characteristics: three weeks,5 crying for at least one week,6 or crying or fussing for at least 90 min each day for six out of Crying is at its maximum in the first three months seven days.6 These different definitions may reflect dif- and an average of about 2 h crying per day is ex- ferent degrees of severity of colic. This lack of a standard pected. This average halves between four and definition in the literature poses a stumbling block when 12 months. comparing the outcome and the validity of much of the Crying peaks at about six weeks, with individual research carried out in this area. In an attempt to over- variation. come this problem, Helseth and Begnum7 proposed a In the first three months, the crying clusters in the comprehensive definition of crying that incorporates late afternoon and evening. The hours between the three categories of crying (intense crying, non-specific 6.00 pm and midnight account for 40% of the 24 h fussing and crying, feeding-related crying) detected in total. their study. They suggest that this proposal may provide an acceptable framework for data collection and assess- Interestingly Brazelton’s study,8 much like the study ment of infants in clinical practice. by St James-Roberts and Halil,10 also showed a pattern It is important to emphasize that a diagnosis of colic of evening clustering of crying in that infants cried most is one of exclusion and that no pathological cause for between 6.00 and 11.00 pm at three weeks of age and the crying can be ascertained. Other possible causes of from 3.00 pm to midnight at six weeks. Although this crying such as hunger, or pathologies such as otitis evening pattern of crying is commonly perceived to be media, intussusception,a anal fissures and urinary tract a diagnostic feature clinically, these two studies have infection need to be ruled out before infants can be con- shown also that infants who are severely colicky tend to sidered colicky. cry throughout the day, rather than just in the evenings. 2.1. Broadening the definition of colic 2. Crying Wessel’s definition of colic2 was based solely on cry- The principal symptom of colic is crying. However, all ing. However, disturbances in sleep, awake and content- neonates and infants cry and there is a daily variation in ment patterns, and disturbances in feeding frequently the amount of crying and the pattern of crying between accompany colic and, therefore, have been used to fur- 4,11,12 infants. Research to determine what constitutes normal ther refine the definition of colic. In addition to crying, other symptoms and signs that may be associated with colic13, 14 include: a Intussusception is the invagination of part of the intestine into itself. The presentation is with a painful cry, drawing up of the knees and going pale, presumably in relation to colic. Vomiting is a common Crying that is difficult to console symptom and the passage of redcurrant jelly stools is frequent. An Feeding problems including spitting, vomiting and abdominal mass is usually papable. crying with feeding 96 K.W. Lim / International Journal of Osteopathic Medicine 9 (2006) 94e102 Poor sleep 1. physiological factors, ranging from cow’s milk intol- Passing a lot of gas erance, immaturity of the gastrointestinal system to immaturity of the central nervous system. Other signs apart from crying that may be reported 2. non-physiological factors, such as difficult infant or observable during a physical examination include: temperament, inappropriate maternal response and deficiencies in parenting. Drawing up of the legs Abdominal distension In addition, mechanical factors may play a part and Hypertonicity these are discussed later as osteopathic considerations Arching in the treatment of infantile colic. Flushing These activities and motor behaviours are non- 3.1. Physiological factors in infantile colic specific and may be observed as accompanying crying in infants in general. But there are some distinguishing 3.1.1. The gastrointestinal tract: pathology features. Mothers often report that colicky infants ap- and physiology pear hungry and that feeding does not always relieve Many physiological reasons for colic are proposed in the crying. Studies have shown too that there are two the medical literature and most relate to the gastrointes- types of crying behaviour.