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Acute

Andreas M Kluftinger MD FRCSC Kelowna General Hospital Disclosure

• Heeadsoyaernia Advisory Panel – Ethicon, Johnson & Johnson

• Funding – nil, zilch, zippo, nada, zero Objectives

• Understand the Pathophysiology and Etiology of the

• Approch to acute abdomen in rural practice

• Case presentations Stedman' s Medical Dictionary 27th Edition

“any serious acute intra-abdominal condition attended by pain, tenderness, and muscular rigidity, and for which emergency must be considered." Acute

• 5-10 % of ER visits • Complex “black box” • De lays in diagnos is can increase mor bidity • Excessive consultations (+/- transport) and imaging can be costly and tax resources. • Primaryygy assessment and triage are key History & Physical

• Onset, nature, duration, location, radiation • Aggravating and relieving factors • Associ a ted GI or GU sympt oms • Past history (Surg and Med) • • Full physical exam Stereotypes of Pain Onset and Associated Pathology

•SddSudden onset •RidRapid onset •GdGradual onset (full pain in seconds) (initial sensation to (hours) full pain over minutes or hours)

•Perforated ulcer •Strangulated •Mesenteric •Strangulated hernia •Ruptured abdominal •Intussusception •Chronic aortic aneurysm •Acute pancreatitis • •Ruptured ectopic •Biliary •Inflammatory bowel disease pregnancy •Diver ticuliti s •MtilhditiMesenteric lymphadenitis • or •Ureteral and renal •Cystitis and urinary retention ruptured cyst colic •Salpingitis and prostatitis •Pulmonary embolism •Acute myocardial infarction Abdominal Innervation Simplified in Thirds

Embryologic Structures Nerves Arteries Pain Location

Foregut Esophagus, Thoracic Coeliac ,3/4 splanchnics, duod,, gb vagus panc

Midgut ¼ duod to Thoracic SMA Periumbilical splenic flexure splanchnics, vagus

Hindgut Left colon , Pelvic IMA rectum, GU splanchnics, tract lesser thoracic splanchnics Possible Causes of Pain by Location

Location of Pain Associated Diseases

Right upper quadrant Acute , , acute hepatitis, duodenal ulcer, right lower (liver, kidney, gallbladder) lobe pneumonia

Right lower quadrant Appendicitis, cecal , , tubo-ovarian abcess, (, appendix, ovary, ruptured ovarian cyst, ovarian torsion fallopian tube)

Left upper quadrant Gastritis, acute pancreatitis, splenic ppgyathology, left lower lobe pneumonia (pancreas, , kidney)

Left lower quadrant Diverticulitis, ectopic pregnancy, tubo-ovarian abcess, ruptured ovarian cyst, (sigmoid and , ovarian torsion ovary, fllifallopian tb)tube)

Midline or periumbilical Appendicitis (early), gastroenteritis, mesenteric lymphadenitis, myocardial or infarction, pacreatitis

Flank Abdominal aortic aneurysm, ,

Front to back Acute pancreatitis, ruptured abdominal aortic aneurysm, retrocecal appendicitis, posterior duodenal ulcer

Suprapubic or lower abdominal Ectopic pregnancy, mittelschmerz, ruptured ovarian cyst, pelvic inflammatory disease, endometriosis, urinary tract infection Sign Finding Association

Cullen's sign Bluish periumbilical Retroperitoneal discoloration hemorrhage pancreatitis, Grey Turner’s sign Bluish discoloration abdominal aortic aneurysm rupture)

Kehr's sign Severe left shoulder pain Splenic rupture Ectopic pregnancy

McBurney' s sign Tenderness located 2/3 distance from Appendicitis ASIS to umbilicus on right side

Murphy's sign Abrupt interruption of inspiration on Acute cholecystitis palpation of right upper quadrant

Iliopsoas sign Hyperextension of right Appendicitis causing abdominal pain

Obturator's sign Internal rotation of flexed right hip Appendicitis causing abdominal pain

Chandelier sign Manipulation of cervix causes patient Pelvic inflammatory to lift off table disease

Rovsing's sign Right lower quadrant pain with Appendicitis palpation of the left lower quadrant Referred Pain

Structure Irritated Location of Referred Pain

Diaphragmatic Supraclavicular area (Kehr's sign)

Ureteral Hypogastrium, , inner thigh

Cardiac pain Epigastrum, jaw, shoulder

Appendix Periumbilical via T10 nerve

DdDuodenum Um bilica l reg ion v ia grea ter thorac ic splanchnic nerve

Hiatal hernia Epigastrum via T7 and T8 nerves

Pancreas or gallbladder Epigastrum

Gallbladder and bile duct Epigastric pain that wraps around to the scapula Imaging for Appendicitis Imaggging Accurac y in AdiitiAppendicitis

Modality Sensitivity Specificity Pos PredValue Neg Pred Value Plain Film 10% 90% Ultrasound 85-90% 92-96% 95% 80-90% CT 95-97% 95% 97% 95-100% MRI 93% 91% 92% 100% Laboratory in Appendicitis

Test Sensitivity Neg Pred Value 1. WBC >10.5 85% 2. Neutrophils >75% 78% 94% 3. C reactive protein 93-96% 1+2 96% 1+3 92.3% 1+2+3 99.2% (81% in children) Urinalysis in Appendicitis

• 30% of appendicitis patients have some urinary syptoms • 14% have >10 WBC/ hpf • 18% have > 3 RBC/hpf Imaging in Pregnancy

• Ultrasound – Safest – Useful for fetal assessment (dates, viability, placenta, amniotic fluid) – NPV for appendicitis 80-90% – PPV for appendicitis 95% Imaging in Pregnancy Procedure Fetal Exposure Chest radiograph (2 views) 0.02-0.07 mrad Abdominal film (single view) 100 mrad Intravenous pyelography >1 rad* Hip film (single view) 200 mrad Mammography 7-20 mrad Barium enema or small bowel series 2-4 rad CT (computed tomography) scan head <1 rad or chest CT scan abdomen and lumbar spine 3.5 rad CT pelvimetry 250 mrad

No evidence of teratogenesis or fetal loss if cumulative dose < 5 rads Acute Abdomen CdbPCaused by Pregnancy

• Early pregnancy – Ruptured ectopic pregnancy – Septic abortion with – Acute urinary retention due to retroverted gravid uterus – Torsion of the pregnant uterus • Later pregnancy – Red degeneration of myoma – Torsion of pedunculated myoma – Placental abruption, Placenta percreta – HELLP (hemolysis, elevated liver function, and low platelets) syndrome – Spontaneous rupture of the liver – Uterine rupture – Chorioamnionitis Conditions Associated with Pregnancy • Acute pyelonephritis • Acute cystitis • AtAcute cho lecys titis • Acute fatty liver of pregnancy • Rupture of rectus abdominis muscle Case #1

• 68 male, 48 hrs RLQ pain • Quick onset, in RLQ • NiNo or anorexia • No urinary syptoms • PHx: GERD, dyslipidemia • Tender RLQ and flank with peritonism • WBC 9.2 Urine clear CT abdomen Case #2

• BW 41 yo electrician • collapsed at home with chest, abd pain • CPR by family, EHS to KGH • PHx: appe Meds: ASA • Exam: BP 60 sys, HR 100 RR 16 Chest clear Abdomen tender, acute Investigations

• Hb 108 WBC 8. 9 Plts 256 • Hep panel – normal • Lipase 43 • ECG – normal • Trop < 0.1 CT with Aorta Protocol Laparotomy

• 3 litres blood • intact liver, spleen, viscera • bloo d from lesser sac • rupured splenic artery aneurysm at hilum • splenectomy, distal pancreatectomy • 4 units FP , 6 units RBC • Recovery uneventful