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Drug Discovery and Development Evotec Partnered Drug Discovery and Development Evotec SE, Company Presentation, July 2019 Forward-looking statement Information set forth in this presentation contains forward-looking statements, which involve a number of risks and uncertainties. We caution investors that forward-looking statements contained herein are based upon management’s expectations and assumptions as of the date of this presentation. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based. PAGE 1 Agenda Overview Partnered drug discovery & development Financials & Outlook PAGE 2 Leading external drug discovery & development Company snapshot 100+ € 375 m+ € 95 m+ Co-owned pipeline programmes with significant Revenues1) Adjusted Group EBITDA1) milestone & royalty potential 25+ 2,700+ 200+ Years track record Top-class employees2) Long-term partnerships 1) In 2018 PAGE 3 Medicine of the future will see radical change Technologies & mega trends Next gen sequencing More precise & early diagnostics iPSC & CRISPR gene editing Patient-centric medicine RNAi technologies, CAR-T Digital health Checkpoint inhibitors Predictive & preventive medicine & Partners Artificial intelligence, big data Value-based care 3D printing, blockchain, wearables, sensors Real-world data,… PAGE 4 Productivity challenge will increase Development costs vs. average peak sales Development Cost, $ m Sales, $ m 1,992 1,188 +68% 816 465 -43% 2010 2017 2010 2017 Cost per asset increased ~2/3rd since 2010 Average peak sales almost halved since 2010 Source: Deloitte’s Centre for Health Solutions: A new future for R&D? Measuring the return from pharmaceutical innovation 2017 PAGE 5 From fixed to variable costs R&D outsourcing in € bn ~30-36 ~85-90 ~10 100% 90% 80% 55 5 (~60%) (~50%) 70% ~7 (~70%) 60% ~25 Capital 50% (~90%) ∑ Elasticity € ~150 bn 40% 30% 35 5 (~50%) (~50%) 20% ~3 10% (~30%) ~3 (10%) 0% 0% 10% 20%30% 40%50% 60% 70% 80%90% 100% Discovery Pre-clinical/IND Manufacturing & Clinical development Others Not outsourced Outsourced Source: Visiongain – Drug Discovery Outsourcing Market Forecast 2015-2025 and Evotec’s estimates PAGE 6 Building a co-owned portfolio in partnerships Unique strategy and business approach – Action Plan 2022 Own R&D Co-Owned Pipeline Action Plan 2022 Fee for Service PAGE 7 R&D solutions up to IND and CMC manufacturing Our core competencies Pre- Hit Lead Target ID/ clinical identi- optimi- Phase I Phase II Phase III Approval Market validation Tox fication sation testing PAGE 8 Multimodality R&D becomes reality Small molecules, biologics & other modalities in R&D Global pharmaceutical market1), 2) US$ bn CAGR 2017-22e +7% 918 856 >50% 794 743 703 670 8% Cell/Gene therapy Biologics 5% Small molecules – EVT Core Expertise 2017 2018e 2019e 2020e 2021e 2022e 1) Small molecules forecast from May 2017 and Biologics forecast from Dec 2017 PAGE 9 2) Excluding sales not classified by EvaluatePharma Source: EvaluatePharma > 2,700 x unique expertise Global centres of excellence Abingdon, Alderley Park ~680 employees 1st J.POD Hamburg, Göttingen, Munich ~610 employees Verona, Basel Branford, Princeton, Seattle, Toulouse, Lyon ~660 employees Watertown ~140 + approx. 95 ~550 employees employees and growing PAGE 10 Agenda Overview Partnered drug discovery & development Financials & Outlook PAGE 11 ONE fully integrated platform EVT Execute & EVT Innovate IP with customers IP with Evotec IP = Intellectual Property PAGE 12 Improving quality and accelerating R&D EVT Execute – Selected performance indicators 1,000,000+ >50 >10 Compounds in highly IND – Pre-clinical & selective library clinical candidates Technology acquisitions1) delivered (INDiGO)1) 92% >1.8 >25% Repeat business2) Years average Faster delivery of data contract time at improved quality 1) Since 2012 PAGE 13 2) In 2018 With “Just.Bio” – Even more integrated offering Comprehensive service panel for external innovation PAGE 14 Building better molecules with better technologies J.DESIGN Technology Platform Molecular J.MD™ – Optimising molecules Design Using machine learning to design and J.MD™ select better biologics through molecular understanding and prediction with Abacus™, an ML software analysis tool JP3® – Optimising process Leverages high throughput technologies Process & Manufacturing to rapidly deliver robust manufacturing Product Design Design processes JP3® J.POD® J.POD® – Manufacturing1) Unique solutions for design of flexible, deployable technologies and facilities needed to improve speed and cost- effectiveness of manufacturing up to commercial supply Quality Speed Capacity Cost 1) J.POD are currently under construction for fastest possible initiation to build in USA and potentially also EU – expected 2021 PAGE 15 Strong and well-balanced global customer mix EVT Execute – Who are our partners? in % Foundations RoW 6 3 Mid-sized Pharma 17 USA 36 46 Biotech Revenue Customer by Region type Q1 20191) Q1 20191) 61 Europe 31 Top 20 Pharma 1) Third-party revenues only PAGE 16 Strong portfolio of highest quality partners EVT Execute alliances – Examples Partnership Partnership Partnership Partnership Partnership Partnership Partnership focused on focused covering broad focused on focused on focused focused on Huntington on various range of DMPK services infectious on various dermatology Disease indications services diseases indications Initiated 2006 Initiated 2011 Initiated 2015 Initiated 2016 Initiated 2016 Initiated 2016 Initiated 2018 Partnership Partnership Partnership for Partnership Partnership Partnership Partnership focused on focused on INDiGO, DD, focused on focused on CNS focused on focused on diabetes & reproductive and CMC oncology oncology oncology obesity medicine & women’s health Initiated 2018 Initiated 2018 Initiated 2015 Initiated 2016 Initiated 2018 Initiated 2017 Initiated 2015 PAGE 17 Building a co-owned pipeline EVT Innovate – Selected performance indicators 7 >€ 1,000 bn >100 Disease areas of Unmet markets Co-owned pipe- core expertise1) addressed line programmes 10 >10 100% Clinical Co- First-in-Class and best-in- owned assets Unpartnered large R&D class approaches “Going for initiatives Cure not for Symptoms” 1) CNS, Pain, Oncology, Respiratory, Diabetes/Metabolic diseases, Women’s health, Infectious disease PAGE 18 Creating massive upside with limited cost & risk Example for co-owned deal structures Performance-based components (Illustrative) Ø 8% Ø € 200 m Milestones (MS) per project € 5-65 m Upfront MS 1MS 2MS 3 MS 4 Clinical MS 5 MS 6 MS 7 Total Royalties R&D cost and/or Start research payments PAGE 19 > 100 projects in fully invested pipeline Partnership portfolio Molecule Therapeutic Area/Indication Partner Discovery Pre-clinical Phase I Phase II EVT201 CNS – Insomnia BAY-1817080 Chronic cough ND1) Chronic cough Ph. II start SGM-10192) Inflammation (NASH) CT7001 Oncology Ph. II start CT7001 Oncology Ph. II start EVT401 Immunology & Inflammation Various Women’s health – Endometriosis Clinical Various Women’s health – Endometriosis Various Women’s health – Endometriosis Various Respiratory ND1) Oncology ND1) Immunology & Inflammation ND1) Pain Various Women’s health – Endometriosis EVT801 Oncology TargetImmuniT Oncology – Immunotherapy ND1) Oncology (+ several discovery programmes) ND1) Fibrosis NEW collaboration Pre-clinical Various Anti-infectives >5 programmes Various CNS, Metabolic, Pain & Inflammation >10 further programmes Various ND1) Nephrology Various ND1) Immunology & Inflammation Various ND1) Nephrology Various ND1) Metabolic – Diabetes Various Oncology Various Immunology & Inflammation – Tissue fibrosis Various Neurodegeneration ND1) Anti-bacterial Various All indications ND1) Dermatological diseases ND1) Facioscapulohumeral Dystrophy INDY inhibitor Metabolic Various Fibrotic disease Fibrocor Therap. / Galapagos Discovery TargetPicV Antiviral Various Anti-infectives >5 programmes Various Internal: Oncology, CNS, Metabolic, Pain & Inflammation >40 further programmes ND1) Oncology NEW collaboration ND1) Novel antibiotics NEW collaboration ND1) Novel antibiotics NEW collaboration ND1) Oncology – Colorectal cancer NEW collaboration 1) Not disclosed PAGE 20 2) Under review – Clinical Phase II trial currently on hold Note: Several projects have fallen back to Evotec, where Evotec does not intend to run further clinical trials unpartnered, e.g. EVT302, EVT101, … Co-owned projects with great partners EVT Innovate alliances – Examples Oncology I Chronic kidney Oncology Fibrosis Neurodegeneration Picornavirus Multi-target alliance disease (“CKD”) Small molecule- Novel mechanisms iPSC-based drug Respiratory Diabetic immunotherapies to in multi-organ fibrosis discovery indications2) complications complement check- point inhibitors1) Initiated 2018 Initiated 2016 Initiated 2015 Initiated 2015 Initiated 2016 Initiated 2017 Oncology II Endometriosis/Pain Diabetes Oncology & Infectious diseases Oncology & Respiratory Respiratory Targeted protein iPSC Beta Cell – Open innovation Joint Venture on degradation Non-hormonal Diabetes alliance Multi-target alliance alliance multiple targets treatments Initiated 2018
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