DOCSLIB.ORG

American Association for Cancer Research's (AACR)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
American Association for Cancer Research's (AACR) AACR Cancer Progress Report 2013 Special Feature on Making Research Count for Patients: A Continual Pursuit Immunotherapy www.cancerprogressreport.org • www.aacr.org AACR Cancer Progress Report 2013 Making Research Count for Patients: A Continual Pursuit Please cite this report as: American Association for Cancer Research. AACR cancer progress report 2013. Clin Cancer Res 2013;19(Supplement 2):S1-S86 www.cancerprogressreport.org • www.aacr.org Table of Contents AACR Cancer Progress Report Writing Committee......................................................................................................................iv A Message from the AACR............................................................................................................................................................vi Executive Summary ....................................................................................................................................................................viii A Snapshot of a Year of Progress..................................................................................................................................................1 The Status of Cancer in 2013 ........................................................................................................................................................2 Definitive Progress has Been Made Against Cancer ...................................................................................................2 Even in the Face of Progress, Cancer Remains a Significant Problem.......................................................................3 Cancer: An Expensive Disease. Biomedical Research: A Wise Investment ................................................................7 What is Cancer?.............................................................................................................................................................................8 The Origins of Cancer ...................................................................................................................................................8 The Genetic Basis of Cancer.........................................................................................................................11 Beyond Genetics: The Role of Epigenetics.....................................................................................................13 Outside Influences ....................................................................................................................................................15 The Immune System.....................................................................................................................................15 Blood and Lymphatic Vessel Networks..........................................................................................................16 Developing Cancer ....................................................................................................................................................17 Prevention and Early Detection...................................................................................................................................................18 Healthy Living Can Prevent Cancer ............................................................................................................................18 Eliminating High-Risk Activities.....................................................................................................................19 Tobacco Use and Cancer .............................................................................................................19 Outdoor and Indoor Tanning and Cancer ......................................................................................22 Cancer-associated Infectious Agents ............................................................................................................23 Energy Balance: Weighing in on Cancer ........................................................................................................24 Obesity and Cancer .....................................................................................................................25 Type 2 Diabetes Mellitus and Cancer ...........................................................................................26 Physical Activity and Cancer ........................................................................................................26 Looking For Cancer: Who, When, and Where.............................................................................................................27 Classifying Risk ............................................................................................................................................28 Prevention and Early Detection of Primary Tumors.......................................................................28 Prevention and Detection of Tumor Recurrence............................................................................33 Making Research Count for Patients: A Continual Pursuit ........................................................................................................35 Special Feature on Immunotherapy: Decades of Research Now Yielding Results For Patients..............................38 Releasing the Brakes on the Immune System ...............................................................................................38 Boosting the Killing Power of the Immune System ........................................................................................43 ii AACR Cancer Progress Report 2013 Flagging Cancer Cells for the Immune System..............................................................................................45 Molecularly Targeted Therapies .................................................................................................................................47 A Direct Hit: Targeting Chemotherapy to Breast Cancer.................................................................................47 Blocking Tumor Sustenance..........................................................................................................................49 Lessons Learned From CML .........................................................................................................................50 Two Drugs: One Cancer-driving Pathway.......................................................................................................53 Helping Some Lung Cancer Patients Breathe Easier......................................................................................53 Closing RANK on a Rare Bone Tumor ............................................................................................................55 Technology Advances for Patient Benefit ..................................................................................................................55 Nanotechnology: Tiny Technologies Make a Big Impact.................................................................................55 Mapping Cancer’s Escape Route...................................................................................................................55 Clear Images with Lower Radiation Doses ....................................................................................................57 Seeing the Wood Through the Trees: Improving Breast Cancer Detection.......................................................57 Genomic Medicine ....................................................................................................................................................57 On the Horizons............................................................................................................................................................................63 The Near Horizon.........................................................................................................................................................63 The Distant Horizon ....................................................................................................................................................64 What Is Required for Continued Progress Against Cancer? ......................................................................................................65 Advancing Regulatory Science and Policy.................................................................................................................65 Engaging Patients in Clinical Research .....................................................................................................................66 Integrating Research and Patient Care ......................................................................................................................67 Improving Biospecimen Repositories ........................................................................................................................67 Cultivating a Highly Skilled and Diverse Cancer Research Workforce .....................................................................67 Funding Cancer Research and Biomedical Science Drives Progress........................................................................................69 Funding Cancer Research and Biomedical Science Saves Lives and Boosts the Nation’s Economy......................69 Sequestration and a Declining Research Budget Threaten the Future of Our Nation’s Health................................70 The AACR Call to Action
Load more

Recommended publications
  • Improved Tumor Vascularization After Anti-VEGF Therapy with Carboplatin and Nab-Paclitaxel Associates with Survival in Lung Cancer
    Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer Rebecca S. Heista,1,2, Dan G. Dudab,1, Dushyant V. Sahanic,1, Marek Ancukiewiczb, Panos Fidiasd, Lecia V. Sequista, Jennifer S. Temela, Alice T. Shawa, Nathan A. Pennelle, Joel W. Nealf, Leena Gandhig, Thomas J. Lynchh, Jeffrey A. Engelmana, and Rakesh K. Jainb,2 Departments of aMedicine, bRadiation Oncology, and cRadiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; dDepartment of Medical Oncology, University of Arizona Cancer Center at Dignity, Phoenix, AZ 85013; eDepartment of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH 44195; fDepartment of Medicine, Division of Oncology, Stanford University/Stanford Cancer Institute, Palo Alto, CA 94305; gDepartment of Adult Oncology, Dana–Farber Cancer Institute, Boston, MA 02115; and hDepartment of Medical Oncology, Yale Cancer Center, New Haven, CT 06520 Contributed by Rakesh K. Jain, December 16, 2014 (sent for review November 18, 2014; reviewed by Elisabeth G. E. De Vries and Daniel Von Hoff) Addition of anti-VEGF antibody therapy to standard chemothera- tumors (3). However, this effect would eventually lead to both pies has improved survival and is an accepted standard of care for decreased drug delivery (and hence treatment resistance) and advanced non–small cell lung cancer (NSCLC). However, the mech- increased tumor hypoxia (a major driver of tumor progression) anisms by which anti-VEGF therapy increases survival remain un- (4). Another potential mechanism of antiangiogenic therapy is clear. We evaluated dynamic CT-based vascular parameters and plasma cytokines after bevacizumab alone and after bevacizumab Significance plus chemotherapy with carboplatin and nab-paclitaxel in ad- vanced NSCLC patients to explore potential biomarkers of treat- A better mechanistic understanding of the survival benefits ment response and resistance to this regimen.
    [Show full text]
  • Tolero Pharmaceuticals February 28Th, 2020 We Are Witnessing a Potential Global Health Crisis
    Lessons Learned from 25 Years of Hunting for Cures BIOUTAH 2020 Entrepreneur & Investor Summit David Bearss Ph.D. CEO Tolero Pharmaceuticals February 28th, 2020 We Are Witnessing a Potential Global Health Crisis 2 This Industry Has an Integral Role in Facing this Type of Crisis • We work in a unique industry • We strive to save millions of lives and help those suffering from disease to recover and lead more productive lives • Our industry employs millions of people who are proud to participate in this crucial endeavor • Although we are the recipients of lot of bad press (some of it deserved) the ongoing commitment of the research-based pharmaceutical industry to improve the quality of life for all of the world’s people is the driving force for those of us in this industry 3 Getting a Drug Approved is Rare and Historical • More than 800,000 people work in the biopharmaceutical industry in the United States across a broad range of occupations, including scientific research, technical support, and manufacturing • Directly and indirectly, the industry supports more than 4.7 million jobs across the United States. • There are only just over 3600 FDA approved drugs for human use • Getting a new drug approved is a very rare and historical event and new drug approvals change the world 4 Just a Few Examples of Drugs that Have Changed our World 1. Penicillin 2. Insulin 3. SmallpoX vaccine 4. Morphine 5. Aspirin 6. Polio vaccine 7. Chlorpromazine or thorazine 8. Chemotherapeutic drugs 9. HIV Protease inhibitors 10. Hormonal contraception 5 In Thinking
    [Show full text]
  • Forma Therapeutics Teams with Tgen Drug Development (Td2)
    FORMA THERAPEUTICS TEAMS WITH TGEN DRUG DEVELOPMENT (TD2) Organizational synergies will create transformative cancer therapies June 19, 2012 WATERTOWN, Mass., and SCOTTSDALE, Ariz. – June 15, 2012 – FORMA Therapeutics and TGen Drug Development (TD2) today announced an agreement to jointly develop transformative cancer therapies, leveraging the synergistic capabilities of both organizations. TD2 is a subsidiary of the Phoenix-based Translational Genomics Research Institute (TGen), a world-renowned biomedical research institute. FORMA and TD2 also announced that Daniel D. Von Hoff, M.D., F.A.C.P., TGen’s Distinguished Professor and Physician-in-Chief, and Stephen Gately, Ph.D., President and Chief Scientific Officer at TD2, will serve as clinical advisors to FORMA. FORMA Therapeutics targets essential cancer pathways to create transformative, small molecule cancer therapies. Its focus on early identification of potent tool compounds helps facilitate target validation, enabling the creation of a robust pipeline of new therapies in areas such as tumor metabolism, protein-protein interactions and epigenetics. TD2’s mission is to facilitate innovative drug development and move new, targeted compounds to patients as quickly as possible. TD2 applies cutting-edge preclinical tools, streamlined and efficient regulatory processes and unique, targeted clinical trial designs and strategies. The combination of cutting-edge science, clinical development expertise and access to patients will accelerate the development of new agents for patients. “I am
    [Show full text]
  • Dr. Daniel Von Hoff and Mr. John Mccray to Join Tau Therapeutics Company Adds Clinical Development and Business Development Expertise for Platform Expansion
    FOR IMMEDIATE RELEASE Contact: Andrew Krouse (434) 974-6969 [email protected] www.tautherapeutics.com Dr. Daniel Von Hoff and Mr. John McCray to Join Tau Therapeutics Company Adds Clinical Development and Business Development Expertise for Platform Expansion (Charlottesville, VA – May 1, 2014) Tau Therapeutics LLC announced two key hires for its executive management team. Daniel D. Von Hoff, M.D., F.A.C.P., will advise Tau on clinical development strategy for its platform of T-type calcium channel inhibitors, including its novel Interlaced Therapy™ approach. John McCray, M.BA, will fill the new position of Chief Business Officer. Both will contribute to the company’s goal of developing and commercializing T-type calcium channel inhibitors for treating solid tumors. Dr. Von Hoff is a recognized expert in clinical trial design, particularly in oncology. He is currently serving a six-year term on the National Cancer Advisory Board and has served on the FDA's Oncology Advisory Committee. Von Hoff is a past president of the American Association for Cancer Research (AACR), was on the AACR and the American Society of Clinical Oncology (ASCO) Board of Directors, and is a fellow of the American College of Physicians. ASCO recently named Dr. Von Hoff one of 50 Oncology Luminaries, celebrating doctors who over the past half-century have significantly advanced cancer care. Dr. Von Hoff has been integral to the development of multiple anticancer agents, including such routinely used agents as mitoxantrone, fludarabine, paclitaxel, docetaxel, gemcitabine, irinotecan, nelarabine, capecitabine, lapatinib. He is currently Physician in Chief and Director of Translational Research at TGen (Translational Genomics Research Institute) in Phoenix, Chief Scientific Officer for US Oncology and for Scottsdale Healthcare's Clinical Research Institute, and Clinical Professor of Medicine at the University of Arizona.
    [Show full text]
  • Cancer Survivorship)
    Published OnlineFirst September 16, 2013; DOI: 10.1158/1078-0432.CCR-13-2107 Clinical Cancer Research The Journal of Clinical and Translational Research AACR Cancer Progress Report 2013 Making Research Count for Patients: A Continual Pursuit Please cite this report as: American Association for Cancer Research. AACR Cancer Progress Report 2013. Clin Cancer Res 2013;19(Supplement 1):S1–S98 www.cancerprogressreport.org • www.aacr.org Downloaded from clincancerres.aacrjournals.org on October 1, 2021. © 2013 American Association for Cancer Research. Published OnlineFirst September 16, 2013; DOI: 10.1158/1078-0432.CCR-13-2107 Table of Contents AACR Cancer Progress Report Writing Committee ....................................................................................................................S4 A Message from the AACR ..........................................................................................................................................................S6 Executive Summary ....................................................................................................................................................................S8 A Snapshot of a Year of Progress .............................................................................................................................................S11 The Status of Cancer in 2013 ....................................................................................................................................................S12 Definitive Progress has
    [Show full text]
  • Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development Matthew D
    Journal of Cancer 2011, 2 142 Journal of Cancer 2011; 2:142-152 © Ivyspring International Publisher. All rights reserved Research Paper An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development Matthew D. Armstrong 1, Daniel Von Hoff 5, Bruce Barber 2, Laura A. Marlow3, Christina von Roemeling3, Simon J. Cooper3, Patrick Travis6, Elizabeth Campbell5, Ricardo Paz-Fumagalli4, John A. Copland3, Gerardo Colon-Otero1 1. Division of Hematology/Oncology; 2. Department of Laboratory Medicine and Pathology; 3. Department of Cancer Biology; 4. Department of Diagnostic Radiology, Mayo Clinic, Jacksonville, Florida, USA; 5. The Translational Genomics Research Institute (TGen), Phoenix AZ, USA; 6. Highlands Oncology Group, Bentonville AR, USA. Corresponding author: Dr. Gerardo Colon-Otero, Division of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, 32224. [email protected] Received: 2011.01.12; Accepted: 2011.02.23; Published: 2011.03.08 Abstract Acinar cell carcinoma of the pancreas is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We report the case of a patient with metastatic ACC who achieved prolonged survival as a result of personalized treatment designed in part on the basis of molecular and in-vitro data collected on analysis of the tumor and a cell line developed from the liver metastasis. To our knowledge, this represents the first human cell line of ACC. The molecular findings on this case and this patient’s cell line may be of use in the management of future cases of this rare tumor and allow the identification of potential novel targets for the effective treatment of this disease.
    [Show full text]
  • 2018 World Pancreatic Cancer Coalition Meeting Scientific Session and Panel Discussion May 9, 2018 Where We Began
    2018 World Pancreatic Cancer Coalition Meeting Scientific Session and Panel Discussion May 9, 2018 Where We Began • According to the WPCC Survey, the first organizations dedicated completely to pancreatic cancer were founded in 1997. • The Hirshberg Foundation for Pancreatic Cancer Research • The National Pancreas Foundation • In 1999, pancreatic cancer received $17.3 million in government funding in the United States through the National Cancer Institute (NCI), which was less than half of 1% of its total budget. • In 2000, the NCI convened a Progress Review Group on Pancreatic Cancer to set an agenda for pancreatic cancer research. Where We Began Continued • A report was released in 2001 which stated: oPancreatic cancer is disproportionately underrepresented in both clinical and basic research compared to other cancer sites. oThe pancreatic cancer research community is encouraged by the comprehensive and effective way that HIV/AIDS has been addressed in America. New dollars poured in to encourage investigators and institutions to create infrastructure and launch new research initiatives. Consequently, transmission and death rates decreased markedly. Where We Are Now • Twenty years later, of the 70+ organizations in the WPCC, there are more than 30 organizations funding pc research. • These groups have invested approximately $240 million in pancreatic cancer research. Research is starting to make an impact. There are more options for patients. Patients are living longer with a better quality of life. Breakthroughs are finally happening. The Lustgarten Foundation • Founded in 1998. • Our mission is to advance the scientific and medical research related to the diagnosis, treatment, cure and prevention of pancreatic cancer. • Since inception, invested more than $154 million in research.
    [Show full text]
  • Summer 2010 Issue
    Translational Genomics Research Institute 02 Swimmer Spans English Channel 04 Dr. David Craig Dives into the Mysteries of Bipolar Disorder 06 ASCO Honors Dr. Daniel Von Hoff 08 Dr. Matt Huentelman Peddles for Alzheimer’s The laTesT ally in The fighT againsT disease 10 canine DNA offers geneTic insighTs inTo cancer, deafness, hearT defecTs, obesiTy, neurologic disorders and more ® summer 2010 A Non-Profit Medical Research Institute Supporting TGen You, too, can make a difference n this issue of TGen Today, we feature Chip and Daryl Weil. We are truly fortunate to have received Itheir generous planned gift to fund our cutting-edge pancreatic cancer research. By naming TGen as a beneficiary of his life insurance policy, Chip ensures that he will leave a legacy in the area of research that he cares about – one that personally has touched his family. You, too, can make a difference by considering a planned gift to TGen. Whether you name TGen as a beneficiary in your life insurance policy, or as a charitable beneficiary of your will or trust, you will have the satisfaction of knowing that your gift will fund research into a broad range of human Denise McClintic diseases, the results of which help shape the future of medicine and lead to new diagnostics and improved treatments for patients. If you or someone you know would like to learn more about making a current or planned gift to TGen, please contact Denise A. McClintic, J.D., LL.M., Associate Vice-President at 602-343-8611 or at [email protected]. Summer 2010 | 1 Translational Genomics Research Institute Cover Story Page 10 — Canine Consortium Initiates Research The DNA of Bernese mountain dogs like this one will be studied at Michigan State University to better understand malignant histiocytic sarcoma, a type of cancer.
    [Show full text]
  • Press Resease
    News Release: 2014 Award of Excellence Honorees Announced Page 1 of 4 Press Release Hope Funds for Cancer Research For Immediate Release Media Contact: Kelly Powers [email protected] 401-847-3286 Hope Funds for Cancer Research Announces 2014 Award of Excellence Recipients NEWPORT, RI -- September 30, 2013 -- The Hope Funds for Cancer Research, dedicated to advancing innovative research for the most difficult-to-treat cancers, today announced its 2014 Award of Excellence honorees in the areas of basic science, clinical development, medicine and philanthropy. These individuals will be recognized at the organization's annual awards dinner on April 24, 2014, being held at The Metropolitan Museum of Art in New York City. The Award of Excellence honors those who have made outstanding contributions to basic, clinical, and medical research in cancer or conducted prominent advocacy and philanthropy on behalf of cancer research. This year's honorees are Tyler Jacks, Ph.D. for Basic Science; Charles L. Sawyers, M.D. for Clinical Development; Daniel D. Von Hoff, M.D. for Medicine; and Jan Vilcek, M.D., Ph.D. for Philanthropy. "These Honorees represent internationally recognized leaders in their fields," stated Dr. Malcolm A.S. Moore, Chairman of the Board of the Hope Funds for Cancer Research. Dr. Tyler Jacks developed mouse strains to carry mutations in genes known to be involved in human cancer. These mice provide invaluable models of many major human cancer cell types, including cancers of the lung, pancreas, colon and ovary. Dr. Charles Sawyers has revolutionized the molecular treatment of cancer. He developed imatinib (Gleevac®) and dasatinib (Sprycel®) for treatment of chronic myeloid leukemia and enzalutamide (Xtandi®) for prostate cancer.
    [Show full text]
  • Daniel D. Von Hoff, M.D., F.A.C.P
    Home | Events | Volunteering | Contact Us | News| Blog SEARCH SIGN UP FOR EMAIL UPDATES RESEARCH » PATIENT INFORMATION » EDUCATION & OUTREACH » ABOUT TGEN » TGEN FOUNDATION » ReGseEaTrc hINVORLeVsEeaDrc h» Faculty Daniel Von Hoff Daniel Von Hoff, MD, FACP Research Faculty PROFILE SELECTED PUBLICATIONS Research Divisions Daniel D. Von Hoff, M.D., F.A.C.P., is currently Physician in Chief and Director of Technology Centers Translational Research at TGen (Translational Genomics Research Institute) in Phoenix, Arizona. He is also Chief Scientific Officer for US Oncology and for TGen North Scottsdale Healthcare's Clinical Research Institute. He is also a Clinical Professor of Medicine, University of Arizona. Center for Rare Childhood Disorders Von Hoff graduated from Carroll College and received his medical degree from Columbia University College of Physicians and Surgeons. He went on to complete his internship and residency in internal medicine at the University of California, San Canine Health & Performance Daniel Von Hoff, M.D., Francisco, and a fellowship in medical oncology at the National Cancer Institute. Von F.A.C.P. Hoff became a professor in the departments of medicine and cellular and structural Macromolecular Analysis & Processing Center biology at the University of Texas Health Science Center, San Antonio. In 1989, he Physician in Chief and became the founding director of the Institute for Drug Development at the Cancer (MAPC) Distinguished Professor Therapy and Research Center in San Antonio and 10 years later he became the TGen director of the cancer center and professor of medicine at the University of Arizona. Research Resources Professor of Medicine Dr. Von Hoff's major interest is in the development of new anticancer agents, both in Mayo Clinic, Clinical the clinic and in the laboratory.
    [Show full text]