Curriculum Vitae

Name: Mr. Surasak Jittavisutthikul Gender : Male Date of Birth : October 23, 1982 Address: Bachgasse 23, 72070 Tuebingen, Germany E-mail: [email protected], [email protected] Tel: +4916095751650 Nationality Thai Race Thai Religion Buddhist Marital status Single

Education: 2009- 2015 Ph.D. (International program in Immunology), Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand. GPA = 3.38. Thesis title: Human single variable antibody fragment (HuscFv) and humanized-camel single domain antibodies (VH/VHH) that neutralize NS3 protease activity of hepatitis C virus (HCV).

2005-2007 Master of Science (Agricultural Biotechnology), Major Field: Agricultural Biotechnology, Interdisciplinary Graduate Program. Kasetsart University, Thailand. GPA = 3.69.

2001-2005 Bachelor of Science (Agricultural Biotechnology), Center for Agricultural Biotechnology, Faculty of Agriculture, Kasetsart University, Thailand GPA = 3.26 (Second Class Honors).

Workshop and Training July 2008 Workshop on “Molecular Techniques for Microbial Identification and Enumeration” by National Center for Genetic Engineering and Biotechnology. During July 8-11, 2008.

October 2007 Workshop on “Good Manufacturing Practices and Quality Systems of Vaccine Manufacturing Plant Design” by Dr. Neophytos Papamichael at Medical Biotechnology Center, Department of Medical Sciences, Ministry of Public Health. During October 1-19, 2007.

December 2007 Training on “Downstream bioprocesses for vaccine production” in the Sartorius Stedim Biotech Company, Gottingen, Germany. During November 3-6, 2007.

September 2008 Training on “Purification of SE36 Protein of Malaria Parasites by Column Chromatography” at Department of Molecular Protozoology, Research Institute for Microbial Diseases (RIMD), Osaka University, Japan. During September 1-12, 2008.

January-April 2015 Ph.D. research on “Production and Purification of Cell Penetrable Human Single Chain Variable Antibody Fragments (HuscFv) That Specific to HCV NS3 protease, EBOV-GP2, EBOV-VP35 and EBOV-VP40 in Good Manufacturing Practice (GMP) Level” at (1) Molecular Virology of Human Infectious Diseases University Clinic Tübingen, Institute of Medical Virology and Epidemiology under supervision of Prof. Dr. Michael Schindler; (2) Microbial Genetics of Interfaculty Institute of Microbiology and Infection Medicine Tübingen under supervision of Prof. Dr. Friedrich Götz; (3) Interfaculty Institute of Biochemistry (IFIB), University of Tübingen. This research was supervised by Prof. Dr. Dr. Rolf G. Werner, Professorship for Industrial Biotechnology, Faculty of Science,University of Tuebingen, and Former Cooperate Senior Vice President Biopharmaceuticals at Böhringer Ingelheim GmbH, Germany and supported by the NSTDA Chair Professor grant of The National Science and Technology Development Agency; the DPG5380001 of the Thailand Research Fund (TRF) and the National Research University (NRU) project of the Office of Commission on Higher Education, Ministry of Education.

Research experiences

2003-March 2007 Researcher Assistant, Department of Pathology, Kasetsart University, Nakorn Pathom (RT-PCR, PCR, cloning and ELISA)

April 2007- July 2007 Researcher, Cell Engineering and Tissue Growth (CETG), Institute of Research and Development of Science and Technology, Mahidol University, Salaya (cell culture, molecular laboratory: Real-Time PCR and RT-PCR)

August 2007-October 2009 Medical Scientist, Medical Biotechnology Center (MBC), Department of Medical Sciences, Ministry of Public Health. (Protein purification of H5N1 protein by using column chromatrography, molecular cloning in E.coli and yeast, DNA sequencing and ELISA)

June 2015-May 2017 Researcher of Laboratory for Research and Technology Development Department of Parasitology and Center of Excellent on Therapeutic Protein and Antibody Engineering, Faculty of Medicine Siriraj Hospital, Mahidol University.

June 2017-Present Postdoctoral researcher of Georg Forster Research Fellowship for postdoctoral researchers of Alexander von Humboldt Foundation under supervision of Prof. Dr. Friedrich Götz; Interfaculty Institute of Biochemistry (IFIB), University of Tübingen and Prof. Dr. Dr. Rolf G. Werner, Professorship for Industrial Biotechnology, Faculty of Science, University of Tuebingen, and Former Cooperate Senior Vice President Biopharmaceuticals at Böhringer Ingelheim GmbH, Germany Research title: Synergistic effects of human single chain antibodies (HuscFvs) and nanobodies (VH/VHH) with β-lactams could help treatment of Methicillin-resistance Staphylococcus aureus (MRSA)

Publications with peer review process

1. Thueng-in, K., Thanongsaksrikul, J., Jittavisutthikul, S., Seesuay, W., Chulanetra, M., Sakolvaree, Y., Srimanote. P., Chaicumpa, W. (2014): Interference of HCV replication by cell penetrable human monoclonal scFv specific to NS5B polymerase. mAbs 2014: 6(5): 1327-1339. IF (2015) = 4.558

2. Jittavisutthikul, S., Thanongsaksrikul, J., Thueng-in., K., Chulanetra, M., Srimanote, P.,

Seesuay, W., Malik, A. A., Chaicumpa, W. (2015): Humanized-VHH Transbodies that Inhibit HCV Protease and Replication. Viruses; 7: 2030-2056. IF (2016) = 3.465

3. Jittavisutthiku1, S., Seesuay, W., Thanongsaksrikul, J., Thueng-in, K., Srimanote, P., Werner, R. G., Chaicumpa, W. (2016): Human single chain transbodies to HCV NS3/4A protease inhibit viral replication and restore host innate immunity. Front. Immunol; 7: 318.

4.Teimoori S., Seesuay W., Jittavisutthikul S., Chaisri U., Sookrung N., Densumite J., Saelim N., Chulanetra M., Maneewatch S., Chaicumpa W. (2016): Human transbodies to VP40 inhibit cellular egress of Ebola virus-like particles. Biochem Biophys Res Commun; 479(2): 245-252. IF (2016) = 2.466

5. Seesuay W., Jittavisutthikul S., Sae-lim N., Sookrung., Sakolvaree., Chaicumpa W. (2018): Human transbodies that interfere with the function of Ebola virus VP35 protein in genome replication and transcription and innate immune antagonism. Emerging Microbes & Infections; 7: 41.