ANTICANCER RESEARCH International Journal of Cancer Research and Treatment

ISSN: 0250-7005

Volume 41, Number 6, June 2021

Contents Reviews Targeting the Supply Lines of Cancer – A Possible Strategy for Combating the Disease? O. ABRAHAMSEN, E. BALSLEV, E. HØGDALL (Copenhagen, Denmark) ...... 2737

The Holocaust Is a Significant and Independent Risk Factor of Late-Onset Cancers: A Systematic Review of the Literature and Original Data on Jewish Israeli, Jewish Non-Israeli and Non-Jewish Non-Israeli Survivors. E. VIRGILIO, D. CAMILLI, G. GILI, F. MONTALI, C. SALVEMINI, A. ANNICCHIARICO, L. PAGLIAI, A. MORINI, A. ROMBOLI, R. COSTI (Parma; Fidenza; Viterbo; Pesaro; L’Aquila; Piacenza, ) ...... 2745

Diet, Probiotics and Physical Activity: The Right Allies for a Healthy Microbiota. R. DIVELLA, G. DE PALMA, A. TUFARO, G. PELAGIO, G. GADALETA-CALDAROLA, R. BRINGIOTTI, A. PARADISO (Bari; Barletta, Italy) ...... 2759

Impact of Topoisomerases Complex Deregulation on Head and Neck Carcinoma Genomic Instability. E. KYRODIMOS, A. CHRYSOVERGIS, N. MASTRONIKOLIS, E. TSIAMBAS, V. RAGOS, D. PESCHOS, D. SPYROPOULOY, P. PANTOS, A. NIOTIS, V. PAPANIKOLAOU (; Patras; Ioannina, ) ...... 2773 Experimental Studies Gene Expression and Survival of Acute Lymphoblastic Leukemia Cells After Allogeneic Transplant. D. SCHENONE, J.R. ANDOLINA, B. RADEMACHER, T.J. FOUNTAINE, E. EDWARDS, L. NUNEZ, M. QIU, S. SHARMA, C.A. MULLEN (Rochester, NY, USA) ...... 2781

Association Between Iron and Cholesterol in Neuroblastomas. S.Y. LEE, B. SLAGLE-WEBB, C.-L. SCHENGRUND, J. ZHU, J.R. CONNOR (Hershey, PA, USA) ...... 2795 Contents continued on the back cover ISSN (print): 0250-7005 ISSN (online): 1791-7530 Editorial Board Editorial Office: International Institute of Anticancer Research, 1st km Kapandritiou-Kalamou Rd., Kapandriti, P.O. Box 22, Attiki 19014, Greece. P. A. ABRAHAMSSON , Malm , Sweden H. KOBAYASHI, Bethesda, MD, USA ö Tel / Fax: +30-22950-53389. B. B. AGGARWAL, San Diego, CA, USA S. D. KOTTARIDIS, Athens, Greece U.S. Branch: Anticancer Research USA, Inc., 111 Bay Avenue, Highlands, T. AKIMOTO, Kashiwa, Chiba, Japan G. R. F. KRUEGER, K ln, NJ 07732, USA. ö P. Z. ANASTASIADIS, Jacksonville, FL, USA Pat M. KUMAR, Manchester, UK E-mails: Editorial Office: [email protected] A. ARGIRIS, San Antonio, TX, USA Shant KUMAR, Manchester, UK Managing Editor: [email protected] J. P. ARMAND, Paris , France O. D. LAERUM, Bergen, Norway ANTICANCER RESEARCH supports: (a) the establishment and the activities V. I. AVRAMIS, Los Angeles, CA, USA F. J. LEJEUNE, Lausanne, of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH (IIAR; D.-T. BAU, Taichung, Taiwan, ROC S. LINDER, Link ping, Sweden Kapandriti, Attiki, Greece); and (b) the organization of the International ö Conferences of Anticancer Research. The IIAR is a member of UICC. For G. BAUER, Freiburg, Germany L. F. LIU, Taipei, Taiwan more information about ANTICANCER RESEARCH, IIAR and the E. E. BAULIEU, Le Kremlin-Bicetre, France D. M. LOPEZ, Miami, FL, USA Conferences, please visit the IIAR website: www.iiar-anticancer.org E. J. BENZ , Jr., Boston, MA, USA E. LUNDGREN, Um ea°, Sweden Publication Data: ANTICANCER RESEARCH (AR) is published bimonthly J.-Y. BLAY, Lyon, France Y. MAEHARA, Fukuoka, Japan from January 1981 to December 2008 and monthly from January 2009. J. BERGH, Stockholm, Sweden J. 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DELINASIOS, Athens, Greece D.T.P. BY IIAR K.L. KNUTSON, Jacksonville, FL, USA Managing Editor (1981-2016) PRINTED BY ENTYPO, ATHENS, GREECE. PRINTED ON ACID-FREE PAPER Announcement - Call for Papers

Special Issue of ANTICANCER RESEARCH 2021 on NEW ANTICANCER AGENTS

Topics :

A. Experimental studies on “ Νew Anticancer Agents ” 1. synthesis and evaluation in vitro and in vivo 2. Mechanism of action 3. Reversal of resistance to anticancer agents 4. oncolytic viruses

B. clinical studies on “New Anticancer Agents” 1. pharmacology 2. clinical trials 3. combination chemotherapy 4. immunotherapeutic agents 5. New methodologies in drug delivery 6. Vaccines

Deadline for submission of original and review articles: October 10, 2021 publication date: December 2021

information: Dr. George J. Delinasios, e-mail: [email protected] Reviews