Evidence-Based Practice Center Systematic Review Protocol
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Cytology of Myeloma Cells
J Clin Pathol: first published as 10.1136/jcp.29.10.916 on 1 October 1976. Downloaded from J. clin. Path., 1976, 29, 916-922 Cytology of myeloma cells F. G. J. HAYHOE AND ZOFIA NEUMAN1 From the Department of Haematological Medicine, Cambridge University SYNOPSIS A cytological, cytochemical, and cytometric study of plasma cells from 195 cases of multiple myeloma showed that, contrary to earlier reports, flaming cells, thesaurocytes, and intra- nuclear inclusions are not confined to IgA-secreting cases but are common also in IgG and Bence Jones varieties of myeloma. IgA-secreting cells are not larger, nor do they have a lower nuclear- cytoplasmic ratio than other myeloma cells. On average, for a given mass of tumour, Bence-Jones, IgG, and IgA varieties of myeloma produce amounts of paraprotein in the ratio 1 to 1 6 to 2-7. In 1961 Paraskevas et al reported a correlation the results of a larger scale survey carried out some between the morphological features of plasma cells years ago but previously unpublished. in myeloma and the type of immunoglobulin secreted. The cases studied included 12 with y1A Material and methods (f2A, IgA) myeloma, 30 with y (IgG) myeloma, and six myelomas without M protein (probably Bence The study was performed on bone marrow smearscopyright. Jones myelomas). Flaming cells, thesaurocytes, and from 200 consecutive patients newly entered into a intranuclear, PAS-positive inclusion bodies were comparative trial of treatments in myeloma, under found only in cases of IgA myeloma, and flaming the auspices of the Medical Research Council. Five cells especially were present in most cases and in patients were subsequently excluded as not confirmed high percentage in several. -
Instant Notes: Immunology, Second Edition
Immunology Second Edition The INSTANT NOTES series Series Editor: B.D. Hames School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK Animal Biology 2nd edition Biochemistry 2nd edition Bioinformatics Chemistry for Biologists 2nd edition Developmental Biology Ecology 2nd edition Immunology 2nd edition Genetics 2nd edition Microbiology 2nd edition Molecular Biology 2nd edition Neuroscience Plant Biology Chemistry series Consulting Editor: Howard Stanbury Analytical Chemistry Inorganic Chemistry 2nd edition Medicinal Chemistry Organic Chemistry 2nd edition Physical Chemistry Psychology series Sub-series Editor: Hugh Wagner Dept of Psychology, University of Central Lancashire, Preston, UK Psychology Cognitive Psychology Forthcoming title Physiological Psychology Immunology Second Edition P.M. Lydyard Department of Immunology and Molecular Pathology, Royal Free and University College Medical School, University College London, London, UK A. Whelan Department of Immunology, Trinity College and St James’ Hospital, Dublin, Ireland and M.W. Fanger Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA © Garland Science/BIOS Scientific Publishers Limited, 2004 First published 2000 This edition published in the Taylor & Francis e-Library, 2005. “To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk.” Second edition published 2004 All rights reserved. No part of this book may be reproduced or -
Canine Multiple Myeloma
Canine Multiple Myeloma Meredith Maczuzak, DVM; Kenneth S. Latimer, DVM, PhD; Paula M. Krimer, DVM, DVSc; and Perry J. Bain, DVM, PhD Class of 2003 (Maczuzak) and Department of Pathology (Latimer, Krimer, Bain), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-7388 Introduction Multiple myeloma or plasma cell myeloma, is a neoplasm of well- differentiated B cell lymphocytes typically originating from the bone marrow. Neoplastic cells can metastasize widely, having a predilection for bone and resulting in osteolysis. The malignant transformation of a single B cell can secrete a homogenous immunoglobulin product known as paraprotein, which will mimic the structure of normal immunoglobulins. Overabundant production of paraprotein, consisting of any of the immunoglobulin classes, will appear as a sharp, well-defined peak or monoclonal gammopathy on serum electrophoresis. The most frequently encountered multiple myelomas secrete IgG or IgA paraproteins, however IgM myelomas (macroglobulinemia) have also been diagnosed in companion animals. Light chain disease is caused by plasma cell overproduction of the light chain segment of the immunoglobulin complex, consisting of either the lambda or kappa light chain. These proteins are referred to as Bence-Jones proteins and are the most commonly observed immunoglobulin fragments in the monoclonal gammopathies.2 There are rare instances where a malignant plasma cell neoplasm will be nonsecretory. These tumors occur in approximately 1% of all cases of multiple myeloma and are referred -
Waldenstrom's Macroglobulinemia
Review Article Open Acc Blood Res Trans J Volume 3 Issue 1 - May 2019 Copyright © All rights are reserved by Mostafa Fahmy Fouad Tawfeq DOI: 10.19080/OABTJ.2019.02.555603 Waldenstrom’s Macroglobulinemia: An In-depth Review Sabry A Allah Shoeib1, Essam Abd El Mohsen2, Mohamed A Abdelhafez1, Heba Y Elkholy1 and Mostafa F Fouad3* 1Internal Medicine Department , Faculty of Medicine, Menoufia University 2El Maadi Armed Forces Institute, Egypt 3Specialist of Internal Medicine at Qeft Teatching Hospital, Qena, Egypt Submission: March 14, 2019; Published: May 20, 2019 *Corresponding author: Mostafa Fahmy Fouad Tawfeq MBBCh, Adress: Elzaferia, Qeft, Qena, Egypt Abstract Objective: The aim of the work was to through in-depth lights on new updates in waldenstrom macroglobulinemia disease. Data sources: Data were obtained from medical textbooks, medical journals, and medical websites, which had updated with the key word (waldenstrom macroglobulinemia ) in the title of the papers. Study selection: Selection was carried out by supervisors for studying waldenstrom macroglobulinemia disease. Data extraction: Special search was carried out for the key word waldenstrom macroglobulinemia in the title of the papers, and extraction was made, including assessment of quality and validity of papers that met with the prior criteria described in the review. Data synthesis: The main result of the review and each study was reviewed independently. The obtained data were translated into a new language based on the need of the researcher and have been presented in various sections throughout the article. Recent Findings: We now know every updated information about Wald Enstrom macroglobulinemia and clinical trials. A complete understanding of the Wald Enstrom macroglobulinemia will be helpful for the future development of innovative therapies for the treatment of the disease and its complications. -
Progression of a Solitary, Malignant Cutaneous Plasma-Cell Tumour to Multiple Myeloma in a Cat
Case Report Progression of a solitary, malignant cutaneous plasma-cell tumour to multiple myeloma in a cat A. Radhakrishnan1, R. E. Risbon1, R. T. Patel1, B. Ruiz2 and C. A. Clifford3 1 Mathew J. Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA, USA 2 Antech Diagnostics, Farmingdale, NY, USA 3 Red Bank Veterinary Hospital, Red Bank, NJ, USA Abstract An 11-year-old male domestic shorthair cat was examined because of a soft-tissue mass on the left tarsus previously diagnosed as a malignant extramedullary plasmacytoma. Findings of further diagnostic tests carried out to evaluate the patient for multiple myeloma were negative. Five Keywords hyperproteinaemia, months later, the cat developed clinical evidence of multiple myeloma based on positive Bence monoclonal gammopathy, Jones proteinuria, monoclonal gammopathy and circulating atypical plasma cells. This case multiple myeloma, pancytopenia, represents an unusual presentation for this disease and documents progression of an plasmacytoma extramedullary plasmacytoma to multiple myeloma in the cat. Introduction naemia, although it also can occur with IgG or IgA Plasma-cell neoplasms are rare in companion ani- hypersecretion (Matus & Leifer, 1985; Dorfman & mals. They represent less than 1% of all tumours in Dimski, 1992). Clinical signs of hyperviscosity dogs and are even less common in cats (Weber & include coagulopathy, neurologic signs (dementia Tebeau, 1998). Diseases represented in this category and ataxia), dilated retinal vessels, retinal haemor- of neoplasia include multiple myeloma (MM), rhage or detachment, and cardiomyopathy immunoglobulin M (IgM) macroglobulinaemia (Dorfman & Dimski, 1992; Forrester et al., 1992). and solitary plasmacytoma (Vail, 2001). These con- Coagulopathy can result from the M-component ditions can result in an excess secretion of Igs interfering with the normal function of platelets or (paraproteins or M-component) which produce a clotting factors. -
Laboratory Bulletin... Updates and Information from Rex Healthcare and Rex Outreach
Laboratory Bulletin... Updates and Information from Rex Healthcare and Rex Outreach June 2003 Issue Number 81 Polyclonal Gammopathy Serum protein electrophoresis (SPEP) is a useful screening test in the evaluation of hypergammaglobulinemia. An elevated gamma globulin level can be suspected in the setting of a patient with an increased total protein, but decreased albumin (e.g. in a comprehensive metabolic profile – CMP). At other times, physicians may order an SPEP as an initial test to “r/o myeloma”. Hypergammaglobulinemia may indeed be the result of a monoclonal gammopathy (in the setting of a plasma cell dyscrasia, lymphoma, amyloidosis or monoclonal gammopathy of undetermined clinical significance - MGUS). 1, 2 Follow-up testing in this case is rather straightforward – immunofixation studies of the serum and/or urine. Polyclonal gammopathy (PG) is another electrophoretic pattern frequently observed in hypergammaglobulinemia. At times, this SPEP interpretation may prompt questions with regard to the clinical significance and whether additional studies are required. Dr. Robert Kyle and associates published a very helpful review of the Mayo Clinic experience with polyclonal gammopathy. 3 They retrospectively studied all patients during a one year period (1991) at the Clinic who had polyclonal gamma globulin level > 3.0 g/dL. (This value was chose to correspond to the cut-off level they used to help distinguish between MGUS and plasma cell dyscrasia. 2) The diagnosis was made by visual inspection of cellulose acetate membranes only. Neither immunofixation nor quantitative immunoglobulin studies were performed. (For the purpose of maintaining a uniform study group, 10 patients who had immunofixation or immunoelectrophoresis performed were excluded from the study. -
Laboratory Testing Requirements for Diagnosis and Follow-Up of Multiple Myeloma and Related Plasma Cell Dyscrasias
Clin Chem Lab Med 2016; 54(6): 907–919 Review Maria A.V. Willrich* and Jerry A. Katzmann Laboratory testing requirements for diagnosis and follow-up of multiple myeloma and related plasma cell dyscrasias DOI 10.1515/cclm-2015-0580 Received June 19, 2015; accepted September 15, 2015; previously Monoclonal gammopathies published online October 28, 2015 overview and categorization Abstract: Monoclonal immunoglobulins are markers of Immunoglobulins are produced by plasma cells, and plasma cell proliferative diseases and have been described clonal plasma cell proliferative diseases usually secrete as the first (and perhaps best) serological tumor marker. a monoclonal immunoglobulin (M-protein) that can The unique structure of each monoclonal protein makes be used as a serologic “tumor” marker. Because of this them highly specific for each plasma cell clone. The dif- secreted monoclonal immunoglobulin, these diseases are ficulties of using monoclonal proteins for diagnosing and also called monoclonal gammopathies. The secreted pro- monitoring multiple myeloma, however, stem from the teins can be used as a diagnostic tool for the identifica- diverse disease presentations and broad range of serum tion of the clone of plasma cells as well as a quantitative protein concentrations and molecular weights. Because of marker to follow the course of the disease and response to these challenges, no single test can confidently diagnose therapy. Unlike most serologic tumor markers, M-proteins or monitor all patients. Panels of tests have been recom- are extremely diverse. The M-proteins each have unique mended for sensitivity and efficiency. In this review we variable region sequences and the molecules may range discuss the various disease presentations and the use of from pentameric IgM (~900,000 Daltons) to monomeric various tests such as protein electrophoresis and immuno- free light chains (~24,000 Daltons). -
Significance of Antiphospholipid Antibodies in Essential Cryoglobulin- Emia: a Case Report and Review of Literature Rama Atluri and Mian Muhammad Rizwan*
Atluri and Rizwan. Clin Med Rev Case Rep 2017, 4:151 Volume 4 | Issue 1 Clinical Medical Reviews ISSN: 2378-3656 and Case Reports Case Report: Open Access Significance of Antiphospholipid Antibodies in Essential Cryoglobulin- emia: A Case Report and Review of Literature Rama Atluri and Mian Muhammad Rizwan* Division of Rheumatology, Saint Louis University, St Louis, USA *Corresponding author: Mian Muhammad Rizwan, Fellow Rheumatology, Division of Rheumatology, 1402 South Grand Boulevard, Doisy Hall, Room 203, St Louis, MO 63104, USA, Tel: 314-977-8832, Fax: 314-977-8818, E-mail: [email protected] monoclonal cryoglobulins. In 1990s it was established that most Abstract of these essential MC are associated with chronic hepatitis C virus Cryoglobulinemia is a rare immune-complex-mediated small vessel (HCV) infection [2,3]. We now know that MC is associated with vasculitis that has a smoldering clinical course and can potentially clinical situations that generate large amounts of IgG and immune involve multiple organ systems. The discovery of its relationship complexes, including chronic autoimmune diseases such as systemic with hepatitis C infection shows the striking association between lupus erythematosus, Sjögren’s syndrome [4] or infections such as a viral infection, an autoimmune disease and lymphoproliferative HCV and HIV infections. MC not associated with those disorders disorders. It is estimated that hepatitis C negative cryoglobulinemia accounts for about 5% to 10% of cases. There have been sporadic has been defined as essential (primary) MC. The clinical features, reports of association between cryoglobulins and antiphospholipid etiologies, and treatment of MC not associated with HCV infection antibody leading to the suspicion that they participate in the have been poorly described. -
Chapter 7: Hematologic Disorders and Kidney Disease
Chapter 7: Hematologic Disorders and Kidney Disease Ala Abudayyeh, MD,* and Kevin Finkel, MD, FACP, FASN, FCCM*† *Division of General Internal Medicine, Section of Nephrology, University of Texas MD Anderson Cancer Center, Houston, Texas; and †UTHealth Science Center at Houston Medical School, Department of Medicine, Division of Renal Diseases and Hypertension, Houston, Texas MULIPLE MYELOMA chains precipitate with Tamm-Horsfall protein (THP) secreted by the thick ascending limb of the Pathogenesis loop of Henle and produce casts in the distal tubule. Multiple myeloma (MM) is a hematologic malig- Decreased GFR may increase the concentration of nancy involving the pathologic proliferation of light chains in the distal tubule and enhance the terminally differentiated plasma cells. It is the formation of casts. Therefore, hypercalcemia, vol- second most common hematologic malignancy ume depletion, diuretics, and nonsteroidal anti- behind non-Hodgkin lymphoma, with an annual inflammatory drugs can exacerbate renal injury. incidence of 4–7 cases per 100,000 in the United In some cases of AKI associated with MM, cast States. Clinical symptoms are due to osteolysis of formation is rare on renal biopsy. Instead, renal the bone, suppression of normal hematopoiesis, injury is attributed to the direct toxic effects of and the overproduction of monoclonal immuno- urinary free light chains (FLCs) on proximal tubule globulins that deposit in organ tissues. Clinical cells (5,6). After reabsorption, lysosomal degrada- symptoms include bone pain and fractures, anemia, tion of FLCs can activate the NF-kB pathway lead- infections, hypercalcemia, edema, heart failure, and ing to oxidative stress with an inflammatory renal disease. response, apoptosis, and fibrosis. -
Hypergammaglobulinemic Purpura of Waldenström
Hypergammaglobulinemic Purpura of Waldenström Amylynne Frankel, MD; Adam Ingraffea, MD; Maureen Massé, MD; Hua Zhou, MD Hypergammaglobulinemic purpura of Waldenström and serum immunofixation showed polyclonal is a rare syndrome that includes recurrent episodic hypergammaglobulinemia with an IgG level of purpura occurring mainly on the lower extremi- 2650 mg/dL (reference range, 562–1585 mg/dL). ties and dorsum of the feet. The hallmark of this A cutaneous biopsy specimen was obtained for condition is polyclonal hypergammaglobulinemia histologic analysis (Figure 2). Histologic sections primarily composed of IgG. Although the condi- showed a perivascular infiltrate composed of lym- tion generally is benign, it may herald an under- phocytes, numerous polymorphonuclear leukocytes lying connective tissue disease or hematologic showing karyorrhexis, and a few admixed eosinophils. malignancy. We report a case of a 47-year-old The vessels were intact without evidence of fibrinoid woman with episodic purpura of 3 years’ duration necrosis. There were extravasated red blood cells associated with Raynaud phenomenon. in the dermis and admixed within the inflamma- Cutis. 2010;86:23-24. tory infiltrate. Iron-stained sections for hemosiderin CUTISwere negative. Prior to diagnosis, the patient had tried using compression stockings that exacerbated her eruption Case Report and concomitant pain. She reported that when she A 47-year-old woman presented with lower extrem- lied down overnight her rash completely resolved and ity pain and swelling of 3 years’ duration followed recurred the following day while working. She did by a bright red, petechial eruption. She was other- not undergo any treatment for this condition and was wiseDo in good health and deniedNot any constitutional referred Copy to an oncologist for further evaluation. -
Hepatitis C Virus Infection a State of Immune Activation in Chronic Intrinsic Resistance to Apoptosis and Reflects Associated Wi
Peripheral Blood B Cell Subset Skewing Is Associated with Altered Cell Cycling and Intrinsic Resistance to Apoptosis and Reflects a State of Immune Activation in Chronic This information is current as Hepatitis C Virus Infection of September 24, 2021. Julia M. Sugalski, Benigno Rodriguez, Susan Moir and Donald D. Anthony J Immunol published online 23 July 2010 http://www.jimmunol.org/content/early/2010/07/23/jimmun Downloaded from ol.1000879 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 24, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Published July 23, 2010, doi:10.4049/jimmunol.1000879 The Journal of Immunology Peripheral Blood B Cell Subset Skewing Is Associated with Altered Cell Cycling and Intrinsic Resistance to Apoptosis and Reflects a State of Immune Activation in Chronic Hepatitis C Virus Infection Julia M. Sugalski,*,† Benigno Rodriguez,*,† Susan Moir,‡ and Donald D. Anthony*,† Chronic hepatitis C virus (HCV) infection is associated with B cell activation, although underlying mechanisms are unclear. -
Intranuclear Inclusions in Myeloma Patient
Published online: 2021-05-24 Letter to Editor Pathologist’s Feast: Intranuclear Inclusions in Myeloma Patient Sir, aspiration [Figure 2]. Plasma cells showed Dutcher body We present a case of a 36‑year‑old female admitted in bone marrow aspiration [Figure 3] as periodic acid– in hospital with complaints of pain in sacral region Schiff positive intranuclear inclusion [Figure 4]. The bone radiating toward right lower limb for 1 month. Laboratory marrow biopsy showed loss of normal architecture with examination revealed hemoglobin 8.1 g/dL, red blood packed marrow studded by plasma cells [Figure 5]. cell count – 2.61 × 109/mm3, white blood cell count Multiple myeloma account for 1% of all cancers and 16.16 × 103/mm3, and platelet count 299 × 109/mm3. The approximately 10% of all hematological malignancies.[1] The differential showed polymorphs – 74%, lymphocytes – 22%, eosinophils – 1%, and monocytes – 3%. Peripheral blood peak incidence is seventh decade, and it is quite rare, below smear showed rouleaux formation in red blood cells. The 40 years of age. The clinical and biological characteristics serum biochemistry showed blood urea – 54 mg/dl and of multiple myeloma in young patients are similar to those [2] creatinine – 3.8 mg/dl, angiotensin converting enzyme in elderly as in literature in studies by Usha et al. and [3] level – 64.25 U/L, and serum calcium – 13.3 mg/dl. Liver Bladé et al. The above case shows ditcher body inclusions function tests and serum electrolytes were normal and in plasma cells on bone marrow aspiration. HIV and HBsAg were nonreactive.