DOCSLIB.ORG

The Journal of Nutrition 1961 Volume.73 No.2

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The Journal of Nutrition 1961 Volume.73 No.2 Lysine Toxicity in the Chick* 1 J. D. JONES2 Department of Animal Husbandry, Iowa State University, Ames, Iowa That a dietary excess of most of the EXPERIMENTAL common amino acids, when fed to experi­ Day-old Cornish X White Rock cross­ mental animals receiving either complete bred chicks, obtained commercially, of both diets or diets lacking an essential nutrient, sexes were housed in electrically heated causes growth retardation is well docu­ batteries with raised screen floors. Ten to mented (Harper et al., ’55), although a 12 chicks were allotted at random to each satisfactory explanation for this observa­ pen using at least 4 pens per treatment. tion has not been proposed. L-lysine has All of the diets were offered ad libitum and been one of the amino acids most fre­ contained the following (in per cent): quently studied as a supplement for dietary casein, 18; gelatin, 10; salts 5 (Briggs et proteins, and both adverse and beneficial al., ’43), 6; com oil, 4; glycerol, 1; DL-me- effects have been observed. Levels of thionine, 0.3; choline chloride, 0.2; inosi­ lysine up to 4% , when added to adequate tol, 0.1; and vitamins (in mg per 100 gm and limiting protein rations, caused a of ration) as follows: thiamine-HC1, 0.6; severe growth depression when fed to day- riboflavin, 0.9; niacin, 5; Ca pantothenate, old chicks, which was partially overcome 2.0; pyridoxine, 0.8; biotin, 0.02; folic acid, by added gelatin (Anderson and Combs, 0.4; a-tocopherol, 0.3; vitamin Bi2, 0.003; ’52); also growth depression and toxicity and menadione, 0.05. Each week 240 ICU symptoms were observed by Jones.3 These of vitamin D3 and 2400 USP units of vita­ symptoms are not as readily observed in min A were given orally. Sucrose was older chicks (Hsu and Combs, ’52) or in added to make each diet up to 100% and rats (Harris and Burress, ’59) fed com­ all supplements were included in the basal parable levels of the amino acid added to ration at the expense of sucrose. The per­ complete or low protein diets. Thus, the centage composition of the basal ration day-old chick appeared to be the preferred was: lysine, 1.73; K, 0.74; and Na, 0.40 by experimental animal for lysine toxicity calculation. studies. Blood obtained by heart puncture, with Since numerous workers (Eckel et al., the chicks under ether anesthesia, was ’58; Iacobellis et al., ’56; Gershoff et al., heparinized for whole blood determina­ ’59) have shown a relationship between tions and centrifuged immediately for the distribution of basic amino acids and plasma determinations. Different birds of electrolytes in rodent tissues, this study the same groups were sacrificed by ether was initiated to compare the distribution anesthesia for the tissue analyses since loss pattern of lysine, Na and K in tissues of of blood has been implicated in altered tis­ the young chick fed excessive amounts of sue electrolyte concentrations (Widdowson lysine with that of the normal young chick. and Southgate, ’59). Lysine was determined Data were obtained in two experiments after supplying diets for various time inter­ Received for publication September 1, 1960. 1 Journal Paper no. J-3932 of the Iowa Agricul­ vals, to determine whether the change in tural and Home Economics Experiment Station, electrolyte composition of the tissues as Ames. Project no. 959. demonstrated for other species (Dickerson 2 Present address: Section of Biochemistry, Mayo Clinic, Rochester, Minnesota. and Widdowson, ’60; Darrow and Heller- 3 Jones, J. D. 1958 Studies on improved nu­ stein, ’58) would be apparent by three trition due to antibiotics. Ph.D. Thesis, Univer­ weeks of age in the chick. sity of Wisconsin, Madison. J. N u t r it io n , 7 3: ’61 107 108 J. D. JONES by a microbiological method (Steele et al., acid and diluted to not more than 3 gm of ’49) modified by the inclusion of 125 ug of tissue to 100 ml of water. At this dilution hydroxylysine per tube4 on ether extracted phosphorus at up to 4 times the maxi­ trichloroacetic acid preparations of serum mum level found in chick tissues was ob­ and homogenized tissue. Concentrations served to have no effect on the concentra­ of tissue components were calculated using tion of either sodium or potassium. Ninhy- a tissue water content of 77%. Deter­ drin-reacting material (NRM), determined mined tissue water was constant among colorimetrically, was used as a measure of treatments. Sodium and potassium were nonprotein nitrogen present in the tissues. determined by flame photometry using a 4 Sauberlich, H. E. 1957 Relationship of hy­ Beckman model B with flame attachment. droxylysine in microbiological assays for lysine. Tissues were digested with fuming nitric Federation Proc., 16: 399 (abstract). 1 25 »100 o * * 7 5 ^ 5 0 o 2 2 5 E 0 L Br. B L Br. B L Br. B L Br. B L Br. -0— I 7 — I I— 1 2 — I 1— 15--- 1 I—2 I—I TIME (days) Fig. 1 The effect of age on Na and K content of selected chick tissues. TABLE 1 The effect of 2% of i-lysine on tissue electrolytes of young chicks 14 days 21 days Treatment Na1 K1 A2 Na K A mmoles/kg mmoles/kg gm mmoles/kg mmoles/kg gm Control Leg 41.2s 95.04 35.5 91.5 Breast 23.44 107.8 22.3 110.1 Brain 58.7 95.7 Heart 58.9 75.5 1064 1644 2% L-Lysine Leg 49.3 81.7 46.2 93.3 Breast 36.2 105.6 30.9 106.7 Brain 57.2 95.5 Heart 55.9 77.2 47 54 1 Values are based on fresh weight and are an average of 10 birds. 2 A is the body weight change of sacrificed birds. 3 Differences between treatments statistically significant (P = 0.05). 4 Differences between treatments statistically significant (P = 0.01). LYSINE TOXICITY 109 All values are given on a wet-weight in CO 05 basis and were subjected to analyses of CD 00 05 variance as described in Snedecor ( ’56). cq r i RESULTS CO CD o C l rH c4 As in previous studies the addition of 5 ^ - 0 5 rH co o 05 O 2% of L-lysine, as the monohydrochloride,5 to the basal ration depressed growth (table ^ Cl CO o rH cq 1) and produced toxicity symptoms such co co CO rH 5 ^ c q h CO CN as hyperirritability, nervousness, leg trem­ ors and later leg weakness. Leg and breast Na were increased by the dietary lysine 0 5 t> while leg K was reduced by the same treat­ 00 0 0 ment after the diet had been fed for 14 days. The two tissues did not react in H1 S» i n ^ rH Tjt i > q a like manner to the dietary treatment at rH LO 0 5 C O C O 0 5 T3 O rH C O O 0 0 O 14 days and only Na distribution still ap­ rH rH rH rH peared to be affected at 21 days indicating H* Sf ai an adaptation to the diet although growth T3 ; ci c o o C J 0 0 ri S ° . ° i had not resumed. Plasma Na and K 1 > i n rH i n tA Ö c q rH c o c q c o c q CÖ showed no deviations due to treatment or Tl OQJ age, and brain and heart tissues showed ci no differences in either Na or K concentra­ (N CO tions due to treatment. CD Since the change in electrolytes caused T3 by excessive dietary lysine appeared to he rÛ.0 a function of the age of the animal, the Tl ï> cq 05 00 0 5 rH distribution of Na and K was determined 5 N C O O t> 05 t> o at varying intervals in a series of chicks from one- to 22-days old (figure 1 and ; Cl I> cq t> cq in 05 0 5 CD *0 control values, table 2). Whole blood ^ cq co cq showed a change only in Na concentration, from 124 to 109 mmoles per liter, while the K content remained constant. Plasma values remained constant for Na and K. In control animals a relatively high con­ Xf t QJ> QJ> centration of Na and low concentration of T5 •go»«« in q QJ QJ QJ S 2^ cq d o o co t> K was observed in both leg and breast Q CO 05 c- co muscle of the day-old birds which had > O +-> -m QJ changed by 12 days to values more similar i O i-j q cq t> «H ci a !^ r-5 i> in ci i f rH 3 co C O ^ to those observed in older birds. ^ cq ^ co ^ CO ■h T J T l No correlation of weight gain could be ri QJ Ö PJ ^ c3 al ci made with the change in tissue electrolyte g cq cq co concentrations within a treatment, the £ T3 . ri ri change being age-dependent only. E-h _bß 0 'S ' qj ’S g ö H rH cq The other experimental variables in this tfl - % * e+H -, ü aj qj cfl e > co “I ^ a n?pH rt S' O ü Ü experiment were the addition of equimolar 05 Cü JL1 bo qj T3 O ÿ i i i H bo qj w bx) ai ^ h CJ QJ QJ (1) M O QJ H O QJ H O r r t Ci h fH H levels of lysine as the free base6 and the _l pq PQ H-j pq pq hlWW OJ jO QJ QJ QJ monohydrochloride (table 2).
Load more

Recommended publications
  • Cosmic Search Issue 06
    North American AstroPhysical Observatory (NAAPO) Cosmic Search: Issue 6 (Volume 2 Number 2; Spring (Apr., May, June) 1980) [All Articles & Miscellaneous Items] Webpage Table of Contents (Bookmarks) (Internal links to items in this webpage) [Note. Use Back button (or <Alt>+<Left Arrow>) to get back to this Table of Contents after you have clicked on a link and viewed the article.] Codes Used Below: P: Starting page of article in magazine; A: Author(s); T: Title of article P: 2; A: Bruce E. Fleury; T: The Aliens In Our Oceans: Dolphins As Analogs P: 6; A: George H. Brown; T: Marconi P: 9; A: Editors; T: Letters P: 10; A: John Kraus; T: Editorial: Technology and the Future of Our Civilization P: 11; A: Editors; T: Space Happenings P: 12; A: Mirjana Gearhart; T: Off the Shelf P: 13; A: I. J. (Irving John "Jack") Good; T: The Chief Entities P: 17; A: Mirjana Gearhart; T: In Review: P: 18; A: Jill Tarter; T: Communication with Extraterrestrial Intelligence P: 19; A: Jill Tarter; T: Life in the Universe P: 20; A: Virginia Trimble; T: Where Are They? P: 26; A: G. Harry Stine; T: Space Industrialization: Opportunity for Space Science P: 30; A: Don Lago; T: In the Time Machine P: 32; A: John Kraus; T: ABCs of Space P: 38; A: Editors; T: College Courses on "Life in the Universe" P: 40; A: Vernon Pankonin; T: Allocating the Radio Spectrum P: 44; A: Robert S. Dixon; T: The SEnTInel (SETI News) P: various; A: Editors; T: Miscellaneous: Information from the Editors, Quotes & Graphics The Aliens In Our Oceans: Dolphins As Analogs By: Bruce E.
    [Show full text]
  • Atomic Health News Is Now Available Through Email
    VOLUME 4, EDITION 2 Claim Denied, But Former Atomic Worker Does Not Give Up “I saw the ash,” recalled Ross, a and said, ‘move everything o the former Electronic Technician at shelves and onto the oor.’ ey Nevada Test Site. “en came the didn’t want anything to fall o and ground waves. It felt like I was break because of the blast.” standing in the middle of the ocean with waves all around.” Ross experienced many once-in-a-lifetime events while Ross recalled one of his experiences working at both Nevada Test Site and aer a nuclear weapon was detonated Idaho National Lab. Unfortunately, underground at the Nevada Test Site, while working at these sites, Ross also where he worked from 1965-1968. experienced exposure to toxic Ross holds his DOL benets card he received chemicals and radiation. Several years from self-ling. Nuclear Care Partners is “ey came in to the equipment trailer ago, Ross was diagnosed with thyroid now providing Ross with guidance on how to add his other conditions to his card. CONTINUED ON PAGE 2... NCP ATOMIC SITE FOCUS AMES LABORATORY A Historical Highlight of One of the Many Nuclear Weapons Facilities Across the Nation e discovery of nuclear ssion in program to accompany the Manhattan 1939 led to advanced research of Project’s existing physics program. e uranium and other rare radioactive Ames Project, as it came to be known, was elements and isotopes. In 1942, Frank responsible for producing high purity Spedding of Iowa State College, an uranium from uranium ores. e Ames expert in the chemistry of rare earth Project group, led by chemist Harley A.
    [Show full text]
  • ORAU TEAM Dose Reconstruction Project for NIOSH
    ORAU TEAM Dose Reconstruction Project for NIOSH Oak Ridge Associated Universities I Dade Moeller & Associates I MJW Corporation Page 1 of 84 Document Title: Document Number: ORAUT-TKBS-0055 Revision: 00 Site Profile for Ames Laboratory Effective Date: 06/22/2007 Type of Document TBD Supersedes: None Subject Expert(s): Jerome B. Martin, Dillard B. Shipler, Donald E. Bihl, Eva E. Hickey, and Bruce A. Napier Site Expert(s): N/A Approval: Signature on File Approval Date: 06/11/2007 Jerome B. Martin, Document Owner Concurrence: Signature on File Concurrence Date: 06/08/2007 John M. Byrne, Task 3 Manager Concurrence: Signature on File Concurrence Date: 06/08/2007 Edward F. Maher, Task 5 Manager Concurrence: Signature on File Concurrence Date: 06/12/2007 Kate Kimpan, Project Director Approval: Brant A. Ulsh Signature on File for Approval Date: 06/22/2007 James W. Neton, Associate Director for Science New Total Rewrite Revision Page Change FOR DOCUMENTS MARKED AS A TOTAL REWRITE, REVISION, OR PAGE CHANGE, REPLACE THE PRIOR REVISION AND DISCARD / DESTROY ALL COPIES OF THE PRIOR REVISION. Document No. ORAUT-TKBS-0055 Revision No. 00 Effective Date: 06/22/2007 Page 2 of 84 PUBLICATION RECORD EFFECTIVE REVISION DATE NUMBER DESCRIPTION 06/22/2007 00 Approved new Site Profile for Ames Laboratory. Incorporates formal internal and NIOSH review comments. Adds Glossary and Attributions and Annotations section. There is no change to the assigned dose and no PER is required. Training required: As determined by the Task Manager. Initiated by Jerome B. Martin Document No. ORAUT-TKBS-0055 Revision No.
    [Show full text]
  • Volume 1 – General Appendix E
    rica MANHATTAN DISTRICT HISTORY EOOK I - GENERAL VOLUME I - GENERAL APPENDIX E GENERAL INDEX Q T ’i COPT ^ / t “gr a s — I------- ----- m m — mm— ^ REDACTED COPY CLASSIFICATION CANCELLED OB-eKnK'G» » ?T- W. <Uic+l<20>. •Y AUTHORITY -tspJiP^y x ' K E S T TA Of iThis dccumerT Restricted Oaf* .... DATE. .f.&lii3 as defined in rnic Cnorgy Act 61 BGLmJAcSOP- 1954. I pU'lcxut* tc any JlCi Department of E *rgy Declas^j ation Review unation: [Circle Number(s)] 1M Review Date 3 ^ 5 assification Retained A uth ority: Q D C g DD Classification Changed To:_____ Contains No DOE Classified Info oordinate W ith:______________ _^slficatlon Cancelled 2nd Review Date: * f/| 1 T^ZlS^gfied Info Bracketed A u th o rity Ihe^fcpe c ify) l§8l p l ® '■". - 'i ,T- ‘:T". '.I ' £Lo iSmoUsll 25441 U.SAE.C., WASH., D, C. SEP 26 1952 (JIEGHNICAL LIBRA RY S & C M l f F M B » SECURITY I^uKMAIIOtf M P H - 6k I Ur,f 1 Rt>pS. THIS DOCUMENT QCNSISTS OF . J . U f . FAGE(S NQ‘ ....... OF ■ COPIES, SERIES MAJJHATTAU DISTRICT HISTORY BOOK I - GEFIEAL VOLOKE I - GENERAL APPENDIX E GENERAL IEDEX 5£gv;:agr~>r JLJUI'HTir EEAHHATlaw GENERAL INDEX Notes t 1. This General Index supplements the Combined Indices of the Manhattan District History, in Appendix C of this Volumei C(l) Index of Names of Persons; C(2) Index of Names of Agencies, Industrial Organizations, P ‘ r-J Universities, etc, 2, The items included in this Index are confined for the most part to general Bubjects end general headings only* for more detailed items, reference should be made to the indices which are included in the separate Books and Volumes of the History, S.
    [Show full text]
  • A1218 Publication Title: Manhattan Engineer District
    Publication Number: A1218 Publication Title: Manhattan Engineer District History Date Published: n.d. MANHATTAN ENGINEER DISTRICT HISTORY CONTENTS Roll Description 1 Book I – General Volume 4 – Auxiliary Activities Chapter 1: Legislative Contacts of Manhattan District Chapter 2: Foundation of the National Laboratories Chapter 3: Program for Production and Administration of Radioisotopes Chapter 4: Research and Development of Atomic Energy for Power Chapter 5: Declassification and Distribution of Project Information Chapter 6: Investigation of the After Effects of the Bombing in Japan Chapter 7: Contributions of Representatives of the Manhattan District to the Discussion and Proposals for International Control Chapter 8: Press Releases, Part I and Part II Statement by the Honorable C.D. Howe, Canadian Minister of Munitions and Supply “A General Account of the Development of Methods of Using Atomic Energy for Military Purposes Under the Auspices of the United States Government, 1940- 1945” by H.D. Smyth, Chairman of the Department of Physics of Princeton University, 1945 A Report on the International Control of Atomic Energy The Atomic Bombings of Hiroshima and Nagasaki Photographs of the Atomic Bombings of Hiroshima and Nagasaki 2 Book I – General Volume 4 – Auxiliary Activities Chapter 9: Assistance on the Canadian Pile Project Chapter 10: The Oak Ridge Institute of Nuclear Studies Chapter 11: Ames Project (Iowa State College) Chapter 12: Activities of the National Bureau of Standards Chapter 13: Preparation and Publication of the Smyth
    [Show full text]
  • Inside Ames Residents Have an Unprecedented Opportunity to Join Six Partners in Building a One-Of- A-Kind Healthy Life Center
    June 2019 City Side Caring People Quality Programs Exceptional Service Healthy Life Center Moves Forward! Informational Meetings in June Inside Ames residents have an unprecedented opportunity to join six partners in building a one-of- a-kind Healthy Life Center. The proposed complex would make healthy living accessible Ames Named and achievable for all people regardless of age and socio-economic status. Learn more 2 Tree City U.S.A. about the proposed Healthy Life Center by attending Healthy Life Center one of five informational meetings scheduled in June. Water Quality Informational Meetings Each meeting will provide an overview of the project, 2 Report Available including proposed plans, amenities and costs. This Monday, June 10 will be followed by a question and answer period. Fee Increases 6 pm, Edwards School, Identified 820 Miller Ave. 2 The Healthy Life Center focuses on a holistic, Community Solar Wednesday, June 12 intergenerational approach to wellness focusing around 3Project Needs You 4 pm, Ames Public Library the idea of “Live Well. Be Well.” Areas of emphasis 515 Douglas Ave. include health and nutrition education, physical Emergency Sirens activities, social networking, and learning and research Provide Warning Thursday, June 13 3 6 pm, Sawyer School opportunities. The facility would include a warm- water indoor aquatic center, indoor walking track and Reducing Summer 4316 Ontario St. Peak Reduces Costs gymnasium, demonstration kitchen for cooking and 4 Monday, June 17 nutrition classes, meeting rooms, and more. 6 pm, Meeker School 300 20th St. The project’s partners are the City of Ames, Heartland Thursday, June 20 Senior Services, Iowa State University, Mary Greeley Noon, Ames High School Medical Center, Story County, and Des Moines Area 1921 Ames High Drive Community College.
    [Show full text]
  • Site Profile for Ames Laboratory Effective Date: 01/03/2012 Type of Document: TBD Supersedes: Revision 02
    ORAU TEAM Dose Reconstruction Project for NIOSH Oak Ridge Associated Universities I Dade Moeller I MJW Technical Services Page 1 of 90 DOE Review Release 01/18/2012 Document Title: Document Number: ORAUT-TKBS-0055 Revision: 03 Site Profile for Ames Laboratory Effective Date: 01/03/2012 Type of Document: TBD Supersedes: Revision 02 Subject Expert(s): Donald E. Bihl Approval: Signature on File Approval Date: 01/02/2012 Jackson R. Ellis, Document Owner Concurrence: Signature on File Concurrence Date: 01/03/2012 John M. Byrne, Objective 1 Manager Concurrence: Signature on File Concurrence Date: 12/29/2011 Edward F. Maher, Objective 3 Manager Concurrence: Vickie S. Short Signature on File for Concurrence Date: 12/29/2011 Kate Kimpan, Project Director Approval: Signature on File Approval Date: 01/03/2012 James W. Neton, Associate Director for Science New Total Rewrite Revision Page Change FOR DOCUMENTS MARKED AS A TOTAL REWRITE, REVISION, OR PAGE CHANGE, REPLACE THE PRIOR REVISION AND DISCARD / DESTROY ALL COPIES OF THE PRIOR REVISION. Document No. ORAUT-TKBS-0055 Revision No. 03 Effective Date: 01/03/2012 Page 2 of 90 PUBLICATION RECORD EFFECTIVE REVISION DATE NUMBER DESCRIPTION 06/22/2007 00 Approved new Site Profile for Ames Laboratory. Incorporates formal internal and NIOSH review comments. Adds Glossary and Attributions and Annotations section. There is no change to the assigned dose and no PER is required. Training required: As determined by the Task Manager. Initiated by Jerome B. Martin. 08/20/2008 00 PC-1 Approved page change revision made to include SEC-00075 on pages 10 and 11 in Section 1.3 where Sections 1.3.1, 1.3.2 and Table 1-2 were added.
    [Show full text]
  • Chicago Pile-1 - Wikipedia, the Free Encyclopedia
    Chicago Pile-1 - Wikipedia, the free encyclopedia https://en.m.wikipedia.org/wiki/Chicago_Pile-1#Later_operation Chicago Pile-1 (CP-1) was the Site of the First Self Sustaining Nuclear world's first nuclear reactor to Reaction achieve criticality. Its construction U.S. National Register of Historic Places was part of the Manhattan U.S. National Historic Landmark Project, the Allied effort to create Chicago Landmark atomic bombs during World War II. It was built by the Manhattan Project's Metallurgical Laboratory at the University of Chicago, under the west viewing stands of the original Stagg Field. The first man-made self-sustaining nuclear chain reaction was initiated in CP-1 on 2 December Drawing of the reactor 1942, under the supervision of Enrico Fermi, who described the apparatus as "a crude pile of black bricks and wooden timbers".[4] The reactor was assembled in November 1942, by a team that included Fermi, Leo Szilard, discoverer of the chain reaction, Location Chicago, Cook County, and Herbert L. Anderson, Walter Illinois, USA Zinn, Martin D. Whitaker, and Coordinates 41°47′32″N 87°36′3″W George Weil. It contained 45,000 Built 1942[2] graphite blocks weighing 400 NRHP Reference # 66000314 [1] short tons (360 t) used as a neutron moderator, and was Significant dates fueled by 6 short tons (5.4 t) of Added to NRHP 15 October 1966 [1] uranium metal and 50 short tons (66000314) (45 t) of uranium oxide. In the Designated NHL 18 February 1965[2] pile, some of the free neutrons Designated CL 27 October 1971[3] produced by the natural decay of uranium were absorbed by other uranium atoms, causing nuclear fission of those atoms, and the release of additional free neutrons.
    [Show full text]
  • The Us Department of Health and Human
    THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE CENTERS FOR DISEASE CONTROL AND PREVENTION NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH convenes the THIRTY-EIGHTH MEETING ADVISORY BOARD ON RADIATION AND WORKER HEALTH VOL. II DAY TWO ABRWH BOARD MEETING The verbatim transcript of the Meeting of the Advisory Board on Radiation and Worker Health held at the Marriott Metro Center, Washington, D.C., on June 15, 2006. 2 C O N T E N T S June 15, 2006 WELCOME AND OPENING COMMENTS 9 DR. PAUL ZIEMER, CHAIR DR. LEWIS WADE, DESIGNATED FEDERAL OFFICIAL AMES SEC PETITION: 10 NIOSH PRESENTATION, DR. JAMES NETON, NIOSH 11 PETITIONER COMMENTS, DR. LARS FUORTES, 38 UNIV. OF IOWA @ AMES WORKING GROUP REPORT, DR. JAMES MELIUS, 45 WORKING GROUP CHAIR BOARD DISCUSSION 68 SENATOR HILLARY CLINTON 100 AMES (CONT’D) 108 NIOSH PRESENTATION ON PARTIAL DOSE RECONSTRUCTIONS 110 FOR NON-PRESUMPTIVE CANCERS, MR. STUART HINNEFELD, NIOSH (CONT’D) 133 CONGRESSMAN TOM UDALL 125 UPDATE ON ISSUES RELATED TO NTS & PPG SEC PETITIONS (250 DAYS), DR. JAMES NETON, NIOSH 148 SENATOR REID’S MESSAGE, SANDI SCHUBERT 163 ROCKY FLATS SEC UPDATE 199 MR. MARK GRIFFON, WORKING GROUP CHAIR COMMENT BY MS. WANDA MUNN 250 Y12 SEC UPDATE: 260 NIOSH PRESENTATION, DR. JAMES NETON, NIOSH 264 WORKING GROUP REPORT 285 MR. MARK GRIFFON, WORKING GROUP CHAIR BOARD DISCUSSION 293 3 SC&A INITIAL PRESENTATION ON 4TH ROUND OF DOSE RECONSTRUCTION CASES, MS. KATHY BEHLING, SC&A 299 PUBLIC COMMENT 325 COURT REPORTER’S CERTIFICATE 381 4 TRANSCRIPT LEGEND The following transcript contains quoted material.
    [Show full text]
  • Women of the Manhattan Project
    ELLEN C. WEAVER, PH.D. Foreword RUTH AND CAROL'S BOOK fills a very personal need for me. I worked on the Manhattan Project in Oak Ridge, but I don't recall any other female scientists working in my groups, and I didn't get to know any of the women working elsewhere at the site. One reason for this was, of course, that women were a small minor- ity on the project. Another is that for security reasons, the various oper- ations at Oak Ridge were spread out over the site and kept separate as much as possible. I met a couple of women in the locker room, where we changed into protective clothing, but we didn't form lasting friend- ships. My buddies were all men. Indeed, I'm ashamed to say that I occa- sionally heard men at Oak Ridge discuss female scientists in insulting terms—concerning appearance, not competence—but that I did not rise to their defense. I remember no sense of camaraderie among women; indeed, we viewed other women with some suspicion. The support that women give one another today did not exist then. I had majored in chemistry in college, not out of any love of science but because I wanted a skill that would empower me to support my hus- band, a physicist, through graduate school. When he was spirited off to a secret project in Oak Ridge, Tennessee, I followed as soon as was prac- ticable. After a short stint cranking out calculations on those old Marchant calculators (talk about boring!), I was put in work in a lab with a real project of my own, and just loved what I was doing.
    [Show full text]
  • Agenda Meeting of the Ames Area Metropolitan Planning
    AGENDA MEETING OF THE AMES AREA METROPOLITAN PLANNING ORGANIZATION TRANSPORTATION POLICY COMMITTEE AND REGULAR MEETING OF THE AMES CITY COUNCIL COUNCIL CHAMBERS - CITY HALL DECEMBER 12, 2017 NOTICE TO THE PUBLIC: The Mayor and City Council welcome comments from the public during discussion. If you wish to speak, please complete an orange card and hand it to the City Clerk. When your name is called, please step to the microphone, state your name for the record, and limit the time used to present your remarks in order that others may be given the opportunity to speak. The normal process on any particular agenda item is that the motion is placed on the floor, input is received from the audience, the Council is given an opportunity to comment on the issue or respond to the audience concerns, and the vote is taken. On ordinances, there is time provided for public input at the time of the first reading. In consideration of all, if you have a cell phone, please turn it off or put it on silent ring. AMES AREA METROPOLITAN PLANNING ORGANIZATION (AAMPO) TRANSPORTATION POLICY COMMITTEE MEETING CALL TO ORDER: 6:00 p.m. 1. Motion setting January 9, 2018, as date of public hearing regarding Amendment to FY 2018- 2021 Transportation Improvement Program 2. Motion setting January 9, 2018, as date of public hearing regarding Amendment to 2015-2019 Final Passenger Transportation Plan POLICY COMMITTEE COMMENTS: ADJOURNMENT: REGULAR CITY COUNCIL MEETING* *The Regular City Council Meeting will immediately follow the meeting of the Ames Area Metropolitan Planning Organization Transportation Policy Committee.
    [Show full text]
  • Cosmic Search Issue 03
    North American AstroPhysical Observatory (NAAPO) Cosmic Search: Issue 3 (Volume 1 Number 3; Summer 1979) [All Articles & Miscellaneous Items] Webpage Table of Contents (Bookmarks) (Internal links to items in this webpage) [Note. Use Back button (or <Alt>+<Left Arrow>) to get back to this Table of Contents after you have clicked on a link and viewed the article.] Codes Used Below: P: Starting page of article in magazine; A: Author(s); T: Title of article P: 2; A: Jay M. Pasachoff & Marc L. Kutner; T: Neutrinos for Interstellar Communication P: 9; A: Editors; T: Letters P: 11; A: Michael A. G. Michaud; T: Extraterrestrial Politics P: 15; A: Editors; T: Editorial: The Stars on Radio (The Washington Post) P: 16; A: B. M. Oliver; T: Bio-Cosmology: A New NASA Thrust P: 21; A: Michael A. Arbib; T: MINDS AND MILLENIA: THe Psychology of Interstellar Communication P: 26; A: Robert S. Dixon; T: The SEnTInel (SETI News) P: 31; A: John Kraus; T: We Wait and Wonder P: 35b; A: Robert S. Dixon; T: Computers and the Garden Path P: 36; A: John Kraus; T: ABCs of Space P: 40; A: Editors; T: In Review: P: 41; A: Editors; T: SETI Popular Topic in Colleges P: 42; A: Mirjana Gearhart; T: Off the Shelf P: 43; A: Jesco von Puttkamer; T: Extraterrestrial Life: Where is Everybody? P: various; A: Editors; T: Miscellaneous: Information from the Editors, Quotes & Graphics ● Information About the Publication (Editorial Board, Editors, Table of Contents) ● Coming in COSMIC SEARCH ● Glossary ● SEARCH AWARDS ● SEARCH PUZZLE; Solution to Jan.
    [Show full text]