Anti-CBLC Monoclonal Antibody, Clone 4E0 (DCABH-3476) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Anti-CBLC monoclonal antibody, clone 4E0 (DCABH-3476) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to Cbl-c Antigen Description Cblc belongs to a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cblc is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitous). Cblc, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cblc knock out mice show no obvious phenotype. Thus, the physiological role of Cblc is not known. Immunogen Recombinant protein fragment corresponding to amino acids 244-474 of Human Cbl-c (NP_036248), produced in E.coli. Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone 4E0 Purity Protein G purified Conjugate Unconjugated Applications WB Positive Control Lysate from HEK293T cells transfected with Cbl-c cDNA. Format Liquid Size 100 μl Buffer pH: 7.30; Preservative: 0.02% Sodium azide; Constituents: 48% PBS, 50% Glycerol, 1% BSA Preservative 0.02% Sodium Azide Storage store at -20°C. Avoid repeated freeze / thaw cycles. Ship Shipped at 4°C. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved GENE INFORMATION Gene Name CBLC Cbl proto-oncogene, E3 ubiquitin protein ligase C [ Homo sapiens ] Official Symbol CBLC Synonyms CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger Entrez Gene ID 23624 Protein Refseq NP_001124324 UniProt ID Q9ULV8 Chromosome Location 19q13.2 Pathway Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem. Function SH3 domain binding; calcium ion binding; epidermal growth factor receptor binding; phosphotyrosine binding; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.

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Upregulation of E3 Ubiquitin Ligase CBLC Enhances EGFR
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