CURRICULUM VITAE Bruce Jason Tromberg, Ph.D. Beckman Laser
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Infrared Active Nanoprobes for Bio-Medical Imaging Based on Inorganic Nanocrystals A
Infrared active nanoprobes for bio-medical imaging based on inorganic nanocrystals A. Podhorodeckia*, L. W. Golackia, B. Krajnika, M. Banskia, A. Lesiaka, A. Noculaka, E.Fiedorczyka, H. P.Woznicaa, J. Cichosb aDepartment of Experimental Physics, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370, Wroclaw, Poland. e-mail: [email protected] bFaculty of Chemistry, University of Wroclaw, ul. F. Joliot-Curie 14, 50-383 Wroclaw, Poland ABSTRACT Fluorescence microscopy is an unique tool helping understanding number of fundametal process on the single In this work we will show the results of optical imaging cells level including both static and dynamic analysis. The with a different types of inorganic nanocrystals. The list of quality of such investigations depends on the properties of probes including hydrophilic NaGdF4:Yb, Er, NaGdF4:Eu fluoroscence probes (in terms of emission quantum yield and PbS nanocrystals all synthesised and modified in our and its stability in time, pH etc.) and performance of group. We will report on their optical porperties and discuss imaging systems. In conventional fluorescence microscopy, examples for perspective work for these types of markers. the lateral resolution is limited by diffraction, which results from the wave nature of light. With the shorten of the Keywords: nanocrystals, optical imaging, infrared, excitation wavelength the resolution improves. However, lanthanides the use of the high energy of UV light is harmful for the living cells and stimulate autofluoroscence. On the other 1 INTRODUCTION hand, recently developed super-resolution fluorescence microscopy allows for beaking diffraction barrier and Optically active inorganic nanocrystals (NCs) (i.e. imaging with resolution of order of magnitude higher than quantum dots, QDs) are recently widely used in research diffration limit [1]. -
Characterization of Diffuse Optical Tomography Scans Using NIRFAST
Characterization of Diffuse Optical Tomography Scans using NIRFAST Sean C. Youn Advisors: Professor W. Cooke and Professor D. Manos Senior Research Coordinator: Professor G. Hoatson May 11, 2015 Abstract Diffuse optical tomography (DOT) and other bio-optical imaging methods have recently emerged as comparable and viable alternatives to more well-established medical imaging technologies. DOT utilizes near-infrared light to create functional images based on differences in the relative scattering and absorbing properties of cellular components and molecules within the tissue in question. This study focused on the forward model portion of the DOT process, which calculates predicted values for the re-emission of near-infrared light across different discretized points within the tissue being imaged. NIRFAST, a software package developed specifically for the purpose of generating DOT scans based on experimental data, was used to simulate and conduct the forward model calculations. Initially, large variations were observed in the calculated values for the intensity and phase shift of the near-infrared light as measured by detectors in the NIRFAST forward model. The primary motivation of this study was to determine the underlying cause between the observed, unrealistic variations in intensity and phase shifts and to determine how the variations could be minimized through changes in the different input parameters involved in the forward model calculation. 1 Motivation Over the past century, medical imaging technologies have developed into integral components of both diagnostics and research, with different imaging methods varying widely in their sets of advantages, disadvantages, and functionality. While X-rays, magnetic resonance imaging, and positron emission to- mography rank among the most widely-used methods, optical imaging has recently gained traction in both clinical and experimental environments due to its versatility and the the low-risk associated with its use (no ionizing radiation or magnetic fields). -
Winter 2017/2018 Laser | Winter 2017/2018
LASER BECKMAN LASER INSTITUTE WINTER 2017/2018 LASER | WINTER 2017/2018 Executive Editor Bruce Tromberg Editors IN THIS ISSUE Gabrielle Comfort Sari Mahon IN THE FORESEEABLE FUTURE 1 Writers Elaine Kato BLIMC CELEBRATES 30 YEARS 2 Erin Miller Deborah Birnie RENAISSANCE IN LIGHT 4 Layout & Design Brian Hill IN MEMORIAM 6 Art TREATING THOSE IN NEED Alexandra Yount 8 Photography IMAGING INNOVATOR 10 Paul Kennedy Staff HONORED FELLOW OF SPIE 10 CEO AT AGE TWENTY-TWO 11 BLIMC Mission FAMILY TREATMENT 12 Discover new optics and photonics technologies for AND THE BEAT GOES ON biomedical research; Create 13 innovative, accessible methods and devices that transform healthcare; and Educate the next generation of Scientists, Engineers, and Physicians. ARNOLD AND MABEL BECKMAN FOUNDATION AND UCI GIFT CHALLENGE COLLABORATIVE GIVING SUPPORTS THE FUTURE OF MEDICINE On the Cover Front: Professor Bernard Choi with Without the vision of Dr. Arnold Beckman, the Beckman Laser Institute and LASER technology for imaging Medical Clinic (BLIMC) would not be the interdisciplinary center that it is blood flow. today. Dr. Beckman, through the Arnold and Mabel Beckman Foundation, Back: Dr. Elliot Botvinick with his provided the original financial gift to establish the BLIMC. As a successful research team. scientist and businessman, Dr. Beckman preferred to donate in the form of matching grants, challenging others to invest. In honor of Dr. Beckman’s spirit of giving to advance science through philanthropic partnerships, Arnold and Mabel Beckman Foundation and UCI have teamed up to offer a $3.5 million matching fund. In order to meet the challenge and continue to move life-changing technologies from “bench to bedside,” we need your help. -
Arjun G. Yodh
BIOGRAPHICAL INFORMATION: ARJUN G. YODH See Group Website for more information: http://www.physics.upenn.edu/yodhlab/ EDUCATION 1986 Ph.D., Harvard University, Division of Applied Sciences 1982 M.S., Harvard University, Division of Applied Sciences 1981 B.Sc., Cornell University, School of Applied and Engineering Physics POSITIONS HELD 1997- Professor of Physics and Astronomy, University of Pennsylvania 1997- Professor of Radiation Oncology, University of Pennsylvania 1993-97 Associate Professor of Physics, University of Pennsylvania 1988-93 Assistant Professor of Physics, University of Pennsylvania 1987-88 Postdoctoral Research Associate with Harry W. K. Tom, AT&T Bell Labs 1986-87 Postdoctoral Research Associate with Steven Chu, AT&T Bell Labs 1982-86 Research Assistant (RA) with Thomas W. Mossberg, Harvard University HONORS, APPOINTMENTS, FELLOWSHIPS, MEMBERSHIPS James M. Skinner Professor of Science, Endowed Chair, Univ. of Pennsylvania (2000- ) Director, PENN Laboratory for Research on Structure of Matter (LRSM) (2009- ) Director, NSF Materials Research Science & Engineering Center (MRSEC) (2009- ) Co-Director, NSF Partnership for Research & Education in Materials (PREM) w/U Puerto Rico (2009- ) Elected Electorate Nominating Committee, American Association for Advancement of Science (2017-20) Alexander von Humboldt Senior Research Award, Heinrich-Heine-University of Düsseldorf (2015-18) Raymond and Beverly Sackler Lecturer, Tel-Aviv University (2015-16) Visiting Professor, École Supérieure of Industrial Physics & Chemistry (ESPCI), -
Irvine Project Summaries 2017-18 to 2018-19
Irvine Project Summaries 2017-18 to 2018-19 Art Museum • 50,000 ASF/84,000 GSF • Constructs an art museum to serve the campus and surrounding community. • Addresses the campus’s lack of space to house and exhibit its art collection, currently scattered among a number of the buildings in the academic core. • Supports campus goal to provide support facilities to accommodate all aspects of campus life. • Will meet minimum of LEED Gold, with a bid alternate for Platinum. • Project will move forward when sufficient gift funding has been raised. Athletics Facilities Improvements • 46,874 ASF/59,646 GSF • Renovates Crawford Hall athletics building to reconfigure Carlos Prietto Sports Medicine room, reconfigure Crawford stage and balcony, and add air conditioning to the building. • Expands facilities at the baseball field to provide a press box and concession facilities, expand viewer seating, and create an identifiable entrance. • Creates a shade structure over the spectator stands at the Aquatics Stadium, creates a separate, identifiable entry, and enhances restrooms at the soccer field. • Renovates the pedestrian/emergency access pathways around the Crawford athletics complex, including entry and wayfinding elements. • Renovates Anteater Stadium, including spectator seating, restrooms, team locker rooms, meeting rooms, and concession areas. • Moves the hammer-throw field into Anteater Stadium and improves safety features to prevent injuries. • Replaces concrete pedestrian walkways and plazas around the Bren Events Center, including increased building security measures and wayfinding elements. • Reconfigures Vista Field and surrounding unimproved areas to create an artificial-turf training facility. • Addresses need for expansion and improvement of athletics facilities. • Will meet minimum of LEED Gold, with a bid alternate for Platinum for Crawford Hall improvements. -
UCI Main Campus
1 2 3 456 7 8 9 10 11 12 TO I-405 A TO A T. TO I-405 ORD C STANF 175 I-405 CU LV ER D 174 R. H TO A R 176 JOHN WAYNE VA RD AIRPORT AV E. 179 181 133 177 141 178 180 130 A 90H RRO B C YO B 98 AMP 132 84 D 182 90 NORTH US D 140 85 R. CAMPUS R. PLAZA VERDE 94 131 183 24 B HOUSING 37 BRIDGE RD. MESA E R AV2 93 ST R D K S COURT 1 A U ARROYO 86 VISTA DEL CAMPO NORTE N E F P 129 3700 O L M HOUSING FIELD E 92 ARBORETUM RD A 21 VISTA 95 C Y C 96 T. 162 AHA HOUSING 184 JAMBOREE RD. AV3 UNIVERSITY DR. 36 185 4199 161 128 UNIVERSITY 38 87 4 29 173 91 160 91 CENTER 39 80 LL 3 5 CORNE PUERTA DEL SOL 23 97 14 . D. 186 T HOUSING R 172 169 C E C 171 I MESA P CL A N E 159 IR L R C 533 I M COURT F C E 168 C E O U I B 167 R O L HOUSING . D 23 R A R C N 188 A V 535 M A D A I 170 E 450 M 158 E A 36 SAN JOAQUIN SA D 9 187 R N PU R CAMINO DEL SOL D R A . 49 O S . A MARSH RESERVE . D R V S R D N E 163 . -
UCI Campus Core
UCI Campus Core 12345678910 11 12 TO NORTH CAMPUS (SEE BOX AT LEFT) TO JOHN WAYNE TO NORTH CAMPUS AIRPORT TO A I-405 I-405 LEGEND A ST BUILDINGS ANFORD 1 PARKING LOTS CAMPUS DR. CT. C 2 DISABLED PARKING A AVAILABLE N 90H MESA M 90 COURT P U WALKWAYS JAMBOREE RD. FIELD S 24 S 93 D T 94 R A FOOTBRIDGES 92 14 . N B 1 F B TO MAIN 3 O BUS STOPS 91 I CT. CAMPUS N R 95 M D INFORMATION BOOTHS/ 91 LU A 3700 CT. H PARKING PERMITS UNIVERSITY DR. 450 80 A TO 5 R SHUTTLE STOPS 98 96 SR73 14A V A TO M 90 ARBORETUM MESA 1 R EMERGENCY PHONES SR73 E D C 97 915 S COURT 4 A 2 A BECKMAN 917 A EMERGENCY ASSEMBLY L V VISTA FIELD R HOUSING I AREAS P E CENTER F D . E . O 49 D 911 . R R R E C E G STUDENT HOUSING C N 59 I D 80 R RI I A B A MPS D 47 40 728 R 907 . 44 727 46 ACADEMY A 913 V 21 E . CRAWFORD 725 Bren 58 722 9 A ATHLETICS Bren R. C 720 34 D A A Center 721 N UNIVERSITY COMPLEX Events 20 O N D 909 723 S RESEARCH Center 715 A E CRAWFORD FIELD 901 T M L PARK E D TO Y 712 P D W 711 . UNIVERSITY I-405 A 710 714 SCPS 4199 Y W CENTER 6A S IN 31 905 713 NO 726 718 T VATI MEDICAL 25 13 A ON PLAZA DR. -
Imaging: a Laboratory Manual, by Rafael Yuste, Editor
Imaging: a laboratory manual, by Rafael Yuste, editor The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Masters, Barry R. “Imaging: A Laboratory Manual, by Rafael Yuste, Editor.” Journal of Biomedical Optics 16 (2011): 039901. © 2011 SPIE. As Published http://dx.doi.org/10.1117/1.3562205 Publisher Society of Photo-optical Instrumentation Engineers Version Final published version Citable link http://hdl.handle.net/1721.1/65838 Terms of Use Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. BOOK REVIEW Hopefully, they will address functional magnetic resonance Imaging: A Laboratory Manual imaging, positron emission tomography, and other techniques Rafael Yuste, Editor 952 pages; ISBN 978-087969-36-9, Cold of medical imaging. Spring Harbor Laboratory Press, Woodbury, New York(2011), $165 The subtitle, A Laboratory Manual is what differentiates the paperback. books in this series from the many textbook and reference books Reviewed by Barry R. Masters, Visiting Scientist, Department that introduce and provide comprehensive summaries of the field of Biological Engineering, Massachusetts Institute of Technol- of imaging. The practical benefit of a laboratory manual is that ogy, and Visiting Scholar, Department of the History of Science, the reader can have the manual opened and flat on the labora- Harvard University, Fellow of AAAS, OSA, and SPIE. E-mail: tory -
Optoacoustic Handheld Imaging for Clinical Screening and Intervention
TECHNISCHE UNIVERSITÄT MÜNCHEN Lehrstuhl für Biologische Bildgebung Optoacoustic handheld imaging for clinical screening and intervention Alexander Dima Vollständiger Abdruck der von der Fakultät für Elektrotechnik und Informationstechnik der Technischen Universität München zur Erlangung des akademischen Grades eines Doktor-Ingenieur (Dr. Ing.) genehmigten Dissertation. Vorsitzender: Univ. - Prof. Dr.-Ing. Martin Buss Prüfer der Dissertation: 1. Univ. - Prof. Vasilis Ntziachristos, Ph. D. 2. Univ. - Prof. Dr.-Ing. Klaus Diepold Die Dissertation wurde am 22.06.2015 bei der Technischen Universität München eingereicht und durch die Fakultät für Elektrotechnik und Informationstechnik am 17.12.2015 angenommen. Abstract Optoacoustic, also known as photoacoustic, imaging is a hybrid imaging modality that combines optical contrast with ultrasound resolution. The method has been studied since the 1990s, yet really took off only in the early 2000s, helped by the sufficient availability of technology components such as nanosecond pulsed lasers in the near- infrared, parallel data acquisition hardware and inversion algorithms. The foremost area of interest during these years has been pre-clinical biomedical imaging of small animals. In mice, reaching tissue diameters of up to 25mm, a number of disease models has been studied ranging from cancers and arthritis to Alzheimer’s. To achieve ever better results a variety of contrast agents has also been applied or newly developed in order to visualize functional and molecular parameters relating to the disease studied. At the same time a desire to increase sensitivity to these agents led to the development of multi-spectral approaches, such as Multi-Spectral Optoacoustic Tomography (MSOT). These techniques also imposed additional requirements in terms of image quality and frame rate that could only be covered by introducing detector arrays and parallel acquisition hardware. -
Ipob Abstract Book.Pdf
Table of contents In vivo detection of residual tumour in breast-conserving surgery using OCT based elastography ............................................................................................................................... 3 4D Megahertz-OCT: Technology and applications ................................................................... 4 Crosstalk-free volumetric in vivo imaging of a human retina and cornea with Fourier-domain full-field optical coherence tomography .................................................................................... 5 Label-free Optical Sensing of Cell State During Biomanufacturing ......................................... 6 Romancing the Startup: Starting the Entrepreneurial Journey on the Right Foot ...................... 7 Developing and validating quantification for OCT Angiography ............................................. 8 Beauty and power of two-photon excitation .............................................................................. 9 High-frame rate multi-meridian corneal imaging of air-puff induced deformation for improved detection of keratoconus .......................................................................................... 10 High finesse tunable Fabry-Perot filters in Fourier-domain mode-locked lasers .................... 11 MEMS Scanning Micromirror Based Multimodal Optical Endoscopic Imaging .................... 12 From pioneer publications to commercial expansion .............................................................. 13 Single exposure -
Characterization of Human Scalp Hairs by Optical Low-Coherence Reflectometry
524 OPTICS LETTERS / Vol. 20, No. 6 / March 15, 1995 Characterization of human scalp hairs by optical low-coherence reflectometry X. J. Wang and T. E. Milner Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, California 92715 R. P. Dhond Washington University, St. Louis, Missouri 63130 W. V. Sorin and S. A. Newton Hewlett-Packard Laboratories, Palo Alto, California 94303 J. S. Nelson Beckman Laser Institute and Medical Clinic, Departments of Surgery and Dermatology, University of California, Irvine, Irvine, California 92715 Received September 19, 1994 Optical low-coherence reflectometry is used to investigate the internal structure and optical properties of human scalp hair. Regardless of hair color, the refractive index of the cortical region remains within the range of 1.56±1.59. The amplitude of the backscattered infrared light coupled into different-colored hair confirms the relative melanin content. Discontinuities in the refractive index permit identification of distinct structural layers within the hair shaft. Photonics industries today use optical low-coherence nates in dark-colored hair. Pheomelanic pigment reflectometry (OLCR) to characterize various ma- is dominant in lighter-colored hair, particularly red terials. Recently OLCR has been applied to char- and blond shades.9 A relative deficiency of melanin acterize biological materials,1 including the human granules results in light colors such as blond and eye2 and skin.3 We have found that this method gray. White hair is believed to be unpigmented.9 also can be useful for investigating biological fibers. In our study, near-infrared light in one arm of a Previous research into the optical properties of hu- fiber-optic interferometer is coupled into the shaft of man hair used external probes to detect scattered an individual human scalp hair (Fig. -
COSI Cancer Biophotonics - Tenured and Tenure Track Faculty Position 2018-2019
COSI Cancer Biophotonics - Tenured and Tenure Track Faculty Position 2018-2019 The Beckman Laser Institute and Medical Clinic (BLIMC) in partnership with the Schools of Engineering and Medicine at the University of California, Irvine (UCI) is seeking applicants for two (tenured/tenure-track) faculty positions in the field of cancer biophotonics, with an expected start date of July 1, 2019. One faculty position is at the Associate Professor level and the other is at the Assistant Professor level. Qualified applicants at other levels will also be considered. The ideal candidate should have research expertise in the development of advanced optics and photonics technologies and their application to problems in cancer biology and medicine. These positions fall under the UCI's high impact program entitled "Convergence Optical Sciences Initiative (COSI)". COSI is a campus priority area that cuts across the fields of Physical Science, Engineering, Biology and Medicine. Activities are expected to lead to the development of advanced light sources and related optics, photonics and computational technologies that drive new systems, devices, and discoveries. Faculty will be appointed in the Schools of Engineering and Medicine as appropriate with opportunities for joint appointments. Membership and access to space and resources in the UCI’s NCI-designated Chao Comprehensive Cancer Center (http://www.cancer.uci.edu) and in BLIMC will also be provided. BLIMC facilities include the David and Lucille Packard Clinic with operating and recovery rooms, optics and photonics research and imaging labs, an animal surgical suite, tissue culture/biochemistry facilities, a histopathology facility, and a photonics incubator for commercialization. Applicants should have a Ph.D., or M.D./Ph.D.