Anatomical Variations of Gall Bladder & Its Association with Post
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2/2/2011 1 Development of Development of Endodermal
2/2/2011 ZOO 401- Embryology-Dr. Salah A. Martin DEVELOPMENT OF THE DIGESTIVE SYSTEM ◦ Primitive Gut Tube ◦ Proctodeum and Stomodeum ◦ Stomach Development of Endodermal Organs ◦ Duodenum ◦ Pancreas ◦ Liver and Biliary Apparatus ◦ Spleen ◦ Midgut Wednesday, February 02, 2011 DEVELOPMENT OF THE DIGESTIVE SYSTEM 2 Wednesday, February 02, 2011 Development of Ectodermal Organs 1 ZOO 401- Embryology-Dr. Salah A. Martin ZOO 401- Embryology-Dr. Salah A. Martin Primitive Gut Tube Proctodeum and Stomodeum The primitive gut tube is derived from the dorsal part of the yolk sac , which is incorporated into the body of The proctodeum (anal pit) is the primordial the embryo during folding of the embryo during the fourth week. anus , and the stomodeum is the primordial The primitive gut tube is divided into three sections. mouth . The epithelium of and the parenchyma of In both of these areas ectoderm is in direct glands associated with the digestive tract (e.g., liver and pancreas) are derived from endoderm . contact with endoderm without intervening The muscular walls of the digestive tract (lamina mesoderm, eventually leading to degeneration propria, muscularis mucosae, submucosa, muscularis of both tissue layers. Foregut, Esophagus. externa, adventitia and/or serosa) are derived from splanchnic mesoderm . The tracheoesophageal septum divides the During the solid stage of development the endoderm foregut into the esophagus and of the gut tube proliferates until the gut is a solid tube. trachea. information. A process of recanalization restores the lumen. Wednesday, February 02, 2011 Primitive Gut Tube 3 Wednesday, February 02, 2011 Proctodeum and Stomodeum 4 ZOO 401- Embryology-Dr. Salah A. -
Embryology, Comparative Anatomy, and Congenital Malformations of the Gastrointestinal Tract
Edorium J Anat Embryo 2016;3:39–50. Danowitz et al. 39 www.edoriumjournals.com/ej/ae REVIEW ARTICLE PEER REVIEWED | OPEN ACCESS Embryology, comparative anatomy, and congenital malformations of the gastrointestinal tract Melinda Danowitz, Nikos Solounias ABSTRACT Human digestive development is an essential topic for medical students and physicians, Evolutionary biology gives context to human and many common congenital abnormalities embryonic digestive organs, and demonstrates directly relate to gastrointestinal embryology. how structural adaptations can fit changing We believe this comprehensive review of environmental requirements. Comparative gastrointestinal embryology and comparative anatomy is rarely included in the medical anatomy will facilitate a better understanding of school curriculum. However, its concepts gut development, congenital abnormalities, and facilitate a deeper comprehension of anatomy adaptations to various evolutionary ecological and development by putting the morphology conditions. into an evolutionary perspective. Features of gastrointestinal development reflect the transition Keywords: Anatomy education, Digestive, Embry- from aquatic to terrestrial environments, such as ology, Gastrointestinal tract the elongation of the colon in land vertebrates, allowing for better water reabsorption. In How to cite this article addition, fishes exhibit ciliary transport in the esophagus, which facilitates particle transport in Danowitz M, Solounias N. Embryology, comparative water, whereas land mammals develop striated anatomy, and congenital malformations of the and smooth esophageal musculature and utilize gastrointestinal tract. Edorium J Anat Embryo peristaltic muscle contractions, allowing for 2016;3:39–50. better voluntary control of swallowing. The development of an extensive vitelline drainage system to the liver, which ultimately creates Article ID: 100014A04MD2016 the adult hepatic portal system allows for the evolution of complex hepatic metabolic ********* functions seen in many vertebrates today. -
Biliary Tract in Trident, an Anatomical Variation Between the Cystic Duct and Its Union to the Common Hepatic Duct
Int. J. Morphol., 37(1):308-310, 2019. Biliary Tract in Trident, an Anatomical Variation Between the Cystic Duct and its Union to the Common Hepatic Duct. A Rare Case Report Tracto Biliar en Tridente, una Variación Anatómica Entre el Conducto Cístico y su Unión al Conducto Hepático Común. Un Caso Raro Oscar Plaza1 & Freddy Moreno2 PLAZA, O. & MORENO, F. Biliary tract in trident, an anatomical variation between the cystic duct and its union to the common hepatic duct. A rare case report. Int. J. Morphol. 37(1):308-310, 2019. SUMMARY: Given that the gallbladder and the biliary tract are subject to multiple anatomical variants, detailed knowledge of embryology and its anatomical variants is essential for the recognition of the surgical field when the gallbladder is removed laparoscopically or by laparotomy, even when radiology procedures are performed. During a necropsy procedure, when performing the dissection of the bile duct is a rare anatomical variant of the bile duct, in this case the cystic duct joins at the confluence of the right and left hepatic ducts giving an appearance of trident. This rare anatomical variant in the formation of common bile duct is found during the exploration of the bile duct during a necropsy procedure, it is clear that the wrong ligation of a common hepatic duct can cause a great morbi-mortality in the post- surgical of biliary surgery. This rare anatomical variant not previously described is put in consideration to the scientific community. Anatomical variants of the biliary tract are associated with high rates of morbidity and mortality, causing serious bile duct injuries. -
A Morphological Study of the Development of the Human Liver I
A Morphological Study of the Development of the Human Liver I. DEVELOPMENT OF THE HEPATIC DIVERTICULUM ’ CHARLES B. SEVERN2 Department of Anatomy, University of Michigan, Ann Arbor, Michigan ABSTRACT The development of the hepatic diverticulum was examined in 38 human embryos representing somite stages 1, 5, 8 and 10 through 29, inclu- sive. Interpretations were based on light microscopic study of serial sections of these embryos. The liver primordium was first identified in a five-somite embryo as a flat plate of endodermal cells continuous with, but lying ventral to, the endoderm of the foregut at the anterior intestinal portal. It is positioned caudal and ventral to the developing heart. This plate of endoderm subsequently undergoes a progres- sive folding due to differential growth of adjacent structures. During the folding process there is a close spatial relationship between the cells of the endodermal plate and the caudal and ventral endothelial lining of the atrium and the sinus venosus. The result of this folding is the establishment of a “T-shaped” diver- ticulum which projects ventrally and cephalically from the gut tract. The hepatic diverticulum is established by the 20 somite-stage embryo. This mode of develop- ment of the hepatic diverticulum is compared to the classical interpretation and to the development of other visceral organs. The lack of an extensive sequential of the intrahepatic duct system, correla- series of human embryonic material has tion of the liver’s developmental pattern prevented past investigators from obtain- with its definitive architectural pattern, ing anything more than general and rather and comparison of the origin and develop- vague concepts as to how the human liver ment of the liver in various species of verte- develops. -
Gastrointestinal Block DEVELOPMENT of PANCREAS & SMALL INTESTINE ﯾﻌﺘﺒﺮ اﻟﻌﻤﻞ ﻣﺼﺪر ﻟﻠﻤﺬاﻛﺮة واﻟﻤﺮاﺟﻌﺔ ______
Gastrointestinal block DEVELOPMENT OF PANCREAS & SMALL INTESTINE ﯾﻌﺘﺒﺮ اﻟﻌﻤﻞ ﻣﺼﺪر ﻟﻠﻤﺬاﻛﺮة واﻟﻤﺮاﺟﻌﺔ ____________________________________________________________________________________________________________ Objectives ★ Describe the development of the duodenum. ★ Describe the development of the pancreas. ★ Describe the development of the small intestine. ★ Identify the congenital anomalies of the small intestine : ● Congenital omphalocele. ● Umbilical hernia. ● Meckel’s diverticulum. Resources ★ 435 embryology (males & females) lectures. ★ BRS embryology Book. ★ Langman embryology book. Color Index ★ IMPORTANT ★ Day, Week, Month ★ Doctor notes and extra information. Team Leaders Afnan AlMalki & Helmi M AlSwerki. ❖ INTRODUCTION the Extra information for better understanding ( ) : Overview ★ The primitive gut tube is formed from the incorporation of the dorsal part of the yolk sac into the embryo due to the craniocaudal folding and lateral folding of the embryo. ★ The primitive gut tube extends from the oropharyngeal membrane to the cloacal membrane and is divided into the foregut, midgut,and hindgut. ★ Arterial supply: ○ Foregut derivatives are supplied by the celiac trunk.The exception to this is the esophagus( not all of the esophagus ). ○ Derivatives of the midgut are supplied by the superior mesenteric artery. ○ Derivatives of the hindgut are supplied by the inferior mesenteric artery. ★ Stages in the development of duodenum, liver, biliary ducts and pancreas (pic.A-D). ★ pic A > 4th week , pic B and C > 5th week , pic D > 6th week ★ Early in the 4th week , the duodenum develops from the endoderm of primordial gut of : Caudal part of foregut , Cranial part of midgut & Splanchnic mesoderm. ★ The junction of the 2 parts of the gut lies just below or distal to the origin of bile duct (pic. C&D). ★ Midgut ( development of small intestine ) : Derivatives of cranial part of the Derivatives of the caudal part of midgut Derivative of the caudal part midgut loop. -
High-Yield Embryology 4
LWBK356-FM_pi-xii.qxd 7/14/09 2:03 AM Page i Aptara Inc High-Yield TM Embryology FOURTH EDITION LWBK356-FM_pi-xii.qxd 7/14/09 2:03 AM Page ii Aptara Inc LWBK356-FM_pi-xii.qxd 7/14/09 2:03 AM Page iii Aptara Inc High-Yield TM Embryology FOURTH EDITION Ronald W. Dudek, PhD Professor Brody School of Medicine East Carolina University Department of Anatomy and Cell Biology Greenville, North Carolina LWBK356-FM_pi-xii.qxd 7/14/09 2:03 AM Page iv Aptara Inc Acquisitions Editor: Crystal Taylor Product Manager: Sirkka E. Howes Marketing Manager: Jennifer Kuklinski Vendor Manager: Bridgett Dougherty Manufacturing Manager: Margie Orzech Design Coordinator: Terry Mallon Compositor: Aptara, Inc. Copyright © 2010, 2007, 2001, 1996 Lippincott Williams & Wilkins, a Wolters Kluwer business. 351 West Camden Street 530 Walnut Street Baltimore, MD 21201 Philadelphia, PA 19106 Printed in China All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appear- ing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Lippincott Williams & Wilkins at 530 Walnut Street, Philadelphia, PA 19106, via email at [email protected], or via website at lww.com (products and services). -
26 April 2010 TE Prepublication Page 1 Nomina Generalia General Terms
26 April 2010 TE PrePublication Page 1 Nomina generalia General terms E1.0.0.0.0.0.1 Modus reproductionis Reproductive mode E1.0.0.0.0.0.2 Reproductio sexualis Sexual reproduction E1.0.0.0.0.0.3 Viviparitas Viviparity E1.0.0.0.0.0.4 Heterogamia Heterogamy E1.0.0.0.0.0.5 Endogamia Endogamy E1.0.0.0.0.0.6 Sequentia reproductionis Reproductive sequence E1.0.0.0.0.0.7 Ovulatio Ovulation E1.0.0.0.0.0.8 Erectio Erection E1.0.0.0.0.0.9 Coitus Coitus; Sexual intercourse E1.0.0.0.0.0.10 Ejaculatio1 Ejaculation E1.0.0.0.0.0.11 Emissio Emission E1.0.0.0.0.0.12 Ejaculatio vera Ejaculation proper E1.0.0.0.0.0.13 Semen Semen; Ejaculate E1.0.0.0.0.0.14 Inseminatio Insemination E1.0.0.0.0.0.15 Fertilisatio Fertilization E1.0.0.0.0.0.16 Fecundatio Fecundation; Impregnation E1.0.0.0.0.0.17 Superfecundatio Superfecundation E1.0.0.0.0.0.18 Superimpregnatio Superimpregnation E1.0.0.0.0.0.19 Superfetatio Superfetation E1.0.0.0.0.0.20 Ontogenesis Ontogeny E1.0.0.0.0.0.21 Ontogenesis praenatalis Prenatal ontogeny E1.0.0.0.0.0.22 Tempus praenatale; Tempus gestationis Prenatal period; Gestation period E1.0.0.0.0.0.23 Vita praenatalis Prenatal life E1.0.0.0.0.0.24 Vita intrauterina Intra-uterine life E1.0.0.0.0.0.25 Embryogenesis2 Embryogenesis; Embryogeny E1.0.0.0.0.0.26 Fetogenesis3 Fetogenesis E1.0.0.0.0.0.27 Tempus natale Birth period E1.0.0.0.0.0.28 Ontogenesis postnatalis Postnatal ontogeny E1.0.0.0.0.0.29 Vita postnatalis Postnatal life E1.0.1.0.0.0.1 Mensurae embryonicae et fetales4 Embryonic and fetal measurements E1.0.1.0.0.0.2 Aetas a fecundatione5 Fertilization -
Cholelithiasis in an Intrahepatic Gallbladder
International Surgery Journal Chandrasekar G et al. Int Surg J. 2017 Sep;4(9):3177-3179 http://www.ijsurgery.com pISSN 2349-3305 | eISSN 2349-2902 DOI: http://dx.doi.org/10.18203/2349-2902.isj20173912 Case Report Cholelithiasis in an intrahepatic gallbladder Chandrasekar G.*, Vivek Nagappa Department of General Surgery, Government Stanley Medical College and Hospital, Chennai, Tamil Nadu, India Received: 19 June 2017 Accepted: 22 July 2017 *Correspondence: Dr. Chandrasekar G., E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Intrahepatic gall bladder (GB) is an uncommonly encountered condition in clinical practice characterized by ectopic location of GB within the hepatic parenchyma. This condition not only produces difficulty in clinical diagnosis of various GB diseases especially cholecystitis and carcinoma but also in their management including cholecystectomy. An ectopic partial intrahepatic GB can make cholecystectomy hazardous, when indicated. A case of cholelithiasis in an intrahepatic gallbladder with concurrent choledocholithiasis is reported. The patient initially presented with pain over the right upper abdomen. The diagnosis was made during intraoperative laparoscopic cholecystectomy. This article discusses about difficultly faced during cholecystectomy and rarity of the presentation. Keywords: Cholelithiasis in ectopic gall bladder, Hepatic cyst like gall bladder, Intrahepatic gall bladder, Laparoscopic removal of intrahepatic gall bladder INTRODUCTION Anatomy An intrahepatic gallbladder is one that is partially or The gallbladder is a piriform (pear-shaped) organ that lies completely embedded within the liver parenchyma. -
Embryology, Histology, and Anatomy
EMBRYOLOGY, HISTOLOGY, 1 AND ANATOMY EMBRYOLOGY intimate contact with the portal mesenchyme At the beginning of fetal development (to- surrounding a portal vein branch (2). In the ward the latter part of the third week of gesta- weeks that follow, certain parts of the ductal tion), the hepatic diverticulum buds from the plates are duplicated by a second layer of cells, ventral foregut. The hepatic diverticulum then to become double-layered ductal plates, which gives rise to the transverse septum (septum then dilate to form cylindrical structures to be transversum), a structure situated between integrated into the mesenchyme of the newly the pericardial and peritoneal cavities (1,2). formed portal region (fig. 1-1). When they are Mesenchymal elements of the transverse sep- integrated into the portal space, the immature tum, which already exist, are invested by liver tubules evolve into bile ducts that are embraced parenchyma formed from hepatic endodermal by connective tissue and gradually situated in cells (also known as hepatoblasts) of the he- their usual location in the portal tracts as the patic diverticulum to give rise to the liver buds portal tracts increase in size (2,7–9). (3). During fetal development the liver buds function as a hematopoietic organ, which is GROSS ANATOMY composed of hepatocytic cords, venous-sinusoi- The liver can be divided into the right and dal plexus, and hematopoietic precursor cells, left lobes by the middle hepatic vein and a plane including Kupffer cells (macrophages residing between the inferior vena cava and the gallblad- in liver). The umbilical vein supplies most of der fossa. -
Left-Sided Gallbladder: Uncommon Presentation and Laparoscopic Approach
CASE REPORT Left-Sided Gallbladder: Uncommon Presentation and Laparoscopic Approach Quoc-Hung “Key” Nguyen, B.A.,1 and Amalanshu Jha, M.D.2 1Albert Einstein College of Medicine, Bronx, NY. 2Department of Surgery, Montefiore Medical Center, Bronx, NY. Sinistroposition, or left-sided placement of the gallblad- can lead to diagnostic difficulty. We present a case of atyp- der, is a rare congenital anomaly with a prevalence of ical presentation of acute cholecystitis from a left-sided about 0.3%. These gallbladders, through multiple pro- gallbladder and the modified laparoscopic technique posed developmental aberrations, are situated beneath used for its safe removal. segment III or IV (or both, as in this case) of the liver, and INTRODUCTION In an era in which laparoscopic cholecystectomy has become sided gallbladder, gallstones, mild wall thickening, disten- the gold standard for treatment of acute cholecystitis, sion, and a sonographic Murphy’s sign (Figure 2). knowledge of developmental anomalies of the gallbladder and biliary system is essential in order to avoid intraopera- The patient underwent laparoscopic cholecystectomy. The tive injury to bile ducts (Suhocki & Meyers, 1999). initial look revealed the gallbladder oriented obliquely, tak- ing off from the right of the midline and coursing toward The embryologic origin of the gallbladder is from the the left side. The falciform ligament was situated normally, hepatic diverticulum, an out-pouching of the primitive fore- with the gallbladder running below and across it to the liver gut (Ando, 2010). During this early development, a number segments III and IV. Further dissection at the Calot’s triangle of malformations may occur: double gallbladder, bilobed revealed that the cystic duct was taking off anterolateral (septate) gallbladder, diverticulum of the gallbladder, or to the common bile duct and the cystic artery was located gallbladder agenesis (Gross, 1936). -
Conservation of Different Mechanisms of Hox Cluster Regulation Within Chordates
Conservation of different mechanisms of Hox cluster regulation within chordates Carlos Herrera Úbeda Aquesta tesi doctoral està subjecta a la llicència Reconeixement- NoComercial – CompartirIgual 4.0. Espanya de Creative Commons. Esta tesis doctoral está sujeta a la licencia Reconocimiento - NoComercial – CompartirIgual 4.0. España de Creative Commons. This doctoral thesis is licensed under the Creative Commons Attribution-NonCommercial- ShareAlike 4.0. Spain License. PHD THESIS 2019 CONSERVATION OF DIFFERENT MECHANISMS OF HOX CLUSTER REGULATION WITHIN CHORDATES CARLOS HERRERA ÚBEDA PHD THESIS 2019 CARLOS HERRERA ÚBEDA Departamento de Genética, Microbiología y Estadística Programa de Doctorado de Genetica 2019 Tesis Doctoral presentada por Carlos Herrera Úbeda bajo el título Conservation of different mechanisms of Hox cluster regulation within chordates para optar al titulo de doctor por la Universitat de Barcelona Firmado, el doctorando Firmado, el Director, responsable asimismo de la tutela de la tesis Jordi Garcia Fernàndez Barcelona, 27 de Septiembre de 2019 We are LEGIONX David Haller Summary 1 Acknowledgements 3 Introduction 9 1. Evolution and development 9 1.1. Dawn of the Evo-Devo 9 1.2. Changes vs Conservation 9 1.3. Amphioxus 10 Overview 10 Development 12 Functional genomics 13 1.4. Xenopus tropicalis 14 1.5. Hox Cluster 15 1.6. ParaHox Cluster 17 2. Long non-coding RNAs 19 2.1. Overview of lncRNAs 19 History 19 Origin and characteristics of lncRNAs 21 Evolution of lncRNAs 22 Classification 23 Challenges 24 2.2. Hotairm1 (HOX antisense intergenic RNA myeloid 1) 25 Overview 25 Mechanism of Hotairm1 26 Objectives 33 Results 37 Article RI 39 Article RII 67 Article RIII 83 Discussion 137 1. -
The Anatomy of the Human Embryo: a Scanning Electron-Microscopic Atlas
The Anatomy of the Human Embryo A Scanning Electron-Microscopic Atlas Dedicated to the memory of the great anatomists and embryologists Wilhelm His (1831–1904) and Erich Blechschmidt (1904–1992) Gerd Steding The Anatomy of the Human Embryo A Scanning Electron-Microscopic Atlas 818 fi gures, 2008 Basel • Freiburg • Paris • London • New York • Bangalore • Bangkok • Shanghai • Singapore• Tokyo • Sydney Dr. med. Gerd Steding Former Professor of Anatomy and Head of the Department of Embryology Centre of Anatomy University of Göttingen Germany Library of Congress Cataloging-in-Publication Data Steding, Gerd. The anatomy of the human embryo : a scanning electron-microscopic atlas / Gerd Steding. p. ; cm. Includes bibliographical references. ISBN 978-3-8055-8361-9 (hard cover : alk. paper) 1. Embryology, Human--Atlases. 2. Scanning electron microscopy--Atlases. I. Title. [DNLM: 1. Embryo, Mammalian--anatomy & histology--Atlases. 2. Microscopy, Electron, Scanning--Atlases. QS 617 S812t 2008] QM602.S738 2008 612.6‘40222--dc22 2008026596 All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any infor- mation storage and retrieval system, without permission in writing from the publisher. © Copyright 2008 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel ISBN 978–3–8055–8361–9 Contents Introduction . VII Acknowledgements . XIII 1. External Aspects . 1 1.1 The External Form of the Embryo . 2 1.2 The Development of the Face .