Phd Day 13 January 2006
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UNIVERSITY OF AARHUS GRADUATE SCHOOL OF HEALTH SCIENCES PhD Day 13 January 2006 2 Welcome The PhD Day is the annual gathering of PhD students enrolled at the University of Aarhus Graduate School Health Sciences. As evident from the present volume containing all submitted abstracts, our Faculty has a large and thriving research environment covering a multitude of clinical, biomedical and public health areas. The studies span contributions from basic investigations in molecular medicine to contributions which address significant challenges to public health. The PhD students perform an important part of the research carried out under the auspices of the Faculty. More than 350 students are enrolled in the Graduate School. Their projects, although firmly rooted in the research activities in Aarhus and Aalborg, have wide international collaboration, emphasizing the Faculty’s high international rating. Students in our Graduate School are thus well-prepared to meet with international leaders in health science research. The program for PhD Day 2006 arranged by the Organizing Committee has focused on the criteria for excellence in research and how scientific results should be published. We therefore welcome the distinguished panel of speakers who have accepted our invitation to contribute. We believe that this PhD Day will, as in previous years, demonstrate the strength of our PhD program, and provide students and supervisors alike with encouragement for their continued scientific activity. On behalf of the Faculty of Health Sciences, The Graduate School of Medicine, and the Organizing Committee, we offer you an enthusiastic welcome to the PhD Day 2006. Michael John Mulvany Thomas Vorup-Jensen Director, Graduate School of Health Sciences Chairman, Organizing Committee Søren Mogensen Dean, Faculty of Health Sciences 3 4 Contents Welcome 3 Information 7 Program 8 Free communication program - oral 10 - posters 11 Invited speakers 33 Abstracts 34 Index 228 Information from the PhD Association 232 5 6 Information Practical information: • Lunch will be held in Lake Auditorium Building • Posters will be shown in Lake Auditorium 5; Bartholin Building reading room and auditoria 3 and 4; Victor Albeck Building • Posters must be set up at 7.30 before the start of the conference, and taken down immediately after the close. • Oral presenters for sessions O1-O4 must meet in the auditorium concerned between 07.30 and 08.00 to put their powerpoint presentation onto the auditorium hard disk. Other oral presenters should meet in auditorium 1 at the first coffee-break 9.25 to load their presentations. Organizing committee: • Thomas Vorup-Jensen (chairman) , Institute of Medical Microbiology • Niels Trolle Andersen, Department of Biostatistics, Institute of Public Health • Birgit Bonefeld, Chairman, PhD Association • Helene Nørrelund, Department of Medicine, Clinical Institute • Louise Østergaard Petersen, Board member, PhD Association • Troels Staehelin Jensen, co-Director of PhD studies • Michael Mulvany, Director of PhD studies Prize committee: • Chairman, Jens Chr. Djurhuus • Co-chairman, Helene Nørrelund • Coordinators: o Oral sessions, Torben Ørntoft o Poster sessions Lake Auditorium 5 (groups 1-6), Michael Hasenkam Bartholin Building (groups 7-14), Raben Rosenberg Victor Albeck Building (groups 15-27), Jens Sandahl Christensen Secretariat: Inge Haislund Andersen, Forskeruddannelsen, The Faculty of Health Sciences, Vennelyst Boulevard 9, 8000 Aarhus C. [email protected] 7 Programme Welcome 8.30 Søren Mogensen (Dean of the Faculty of Health Sciences) Michael Mulvany (Director, PhD studies) Birgit Bonefeld (Chairman, PhD Association) Thomas Vorup-Jensen (Chairman, organizing committee) Health science research process. Chairman Troels Staehlin Jensen, co-Director PhD studies 8.45 Tomas Hökfelt, Karolinska Institute, Neuropeptides: from basics to the clinic 9.25 Tea/coffee Medical publishing. Chairmen Povl Riis, former editor Journal of the Danish Medical Association (Ugeskrift for Læger), Michael Mulvany, Director PhD studies 9.55 Fiona Godlee, Editor British Medical Journal. Protecting medical publishing from bias 10.35 Torben Schroeder, Editor Journal of the Danish Medical Association Ethics of medical publishing 10.55 Discussion - 11.10 Oral communications 11.20 Parallel sessions Session O1. Chairmen: Mogens Kilian, Lise Wogensen Bach Auditorium 1 Session O2 Chairmen: Søren Moestrup, Leif Mosekilde Auditorium 2 Session O3 Chairmen: Torsten Toftegaard, Christian Aalkjær Auditorium 3 Session O4 Chairmen: Hans Gregersen, Ebba Nexø Auditorium 4 8 12.35 Lunch Poster session 13.00 Poster viewing 13.30 Poster visits (for chairmen see poster programme) Groups P1-P6 Auditorium 5 Groups P7-P14 Bartholin Building Teaching Wing Groups P15-P27 Victor Albeck Building Training in health science research. Chairmen: Hans Jørn Kolmos, Director of PhD studies, University of Southern Denmark Jørgen Vinten, Director of PhD studies, University of Copenhagen 14.45 Seppo Meri, Helsinki University Research training: an international perspective 15.15 Discussion Special lecture. Chairman Søren Nielsen, Institute of Anataomy, University of Aarhus 15.30 Peter Agre, Duke University, Nobel Laureate. What is good research? Closing remarks 16.15 Søren Mogensen Social programme 18.30 Dinner, Entertainment and Dance, Stakladen. Jens Christian Djurhuus: Announcement of the prizes Lars Bolund; Festive speech 9 Free communications program Presenting authors and title. For co-authors and affiliation see abstracts. Oral session O1. Chairmen: Mogens Kilian, Lise Wogensen Bach O1.01 Hanne Vebert Olesen. VIRAL AND ATYPICAL BACTERIAL INFECTIONS IN CHILDREN WITH CYSTIC FIBROSIS O1.02 Mette Skytte Tetsche. PROGNOSIS OF OVARIAN CANCER ASSOCIATED WITH VENOUS THROMBOEMBOLISM: A NATIONWIDE DANISH COHORT STUDY O1.03 Irene Dige. QUANTITATIVE MEASUREMENT OF BACTERIA IN DENTAL BIOFILMS: A PILOT STUDY O1.04 Mette Møller-Kristensen. DEFICIENCY OF MANNAN-BINDING LECTIN GREATLY INCREASES SUSCEPTIBILITY TO POST-BURN INFECTION WITH PSEUDOMONAS AERUGINOSA O1.05 Thomas Nielsen. RELATIONSHIP BETWEEN COMBRETASTATIN INDUCED CHANGES IN DCEMRI PARAMETERS AND RADIATION RESPONSE IN A MURINE TUMOUR MODEL Oral session O2. Chairmen: Søren Moestrup, Leif Mosekilde O2.01 Anja Pernille Einholm. MUTATION OF GLY94 IN TRANSMEMBRANE SEGMENT M1 OF THE NA+,K+-ATPASE INTERFERES WITH NA+ AND K+ BINDING IN E2P CONFORMATION O2.02 Ramune Aleksyniene. EFFECTS OF PARATHYROID HORMONE TREATMENT ON DISTRACTION OSTEOGENESIS IN THE RABBIT TIBIAL LENGTHENING MODEL O2.03 Marianne Jensby Nielsen. MOLECULAR CHARACTERIZATION OF THE HAPTOGLOBIN-HEMOGLOBIN RECEPTOR CD163: ENDOCYTIC PROPERTIES OF THE CYTOPLASMIC TAIL OF PHYSIOLOGICAL CD163 VARIANTS O2.04 Mathias Hauge Bünger. THE EFFECTS OF STRONTIUM ON BONE ULTRASTRUCTURE: INSIGHTS FROM LABORATORY SCANNING SMALL ANGLE X- RAY SCATTERING (SSAXS) O2.05 Bjarke Moosgaard. VITAMIN D STATUS AND SEASONAL VARIATIONS IN PRIMARY HYPERPARATHYROIDISM 10 Oral session O3. Torsten Toftegaard, Christian Aalkjær O3.01 Kim Holmgaad Jensen. THE IMPAIRMENT OF RETINAL VASOCONSTRICTION CAUSED BY PERIVASCULAR TISSUE CAN BE BLOCKED BY INHIBITION OF THE GLUTAMATE NMDA RECEPTOR AND COX O3.02 Niels Jessen. ALTERED SUBSTRATE METABOLISM AND ABLATED AMPKΑ2 ACTIVITY IN LKB1 KNOCKOUT HEARTS O3.03 Rikke Nørregaard. SEGMENTAL AQP2 REGULATION BY SELECTIVE COX-2 INHIBITION IN AFTER RELEASE OF BILATERAL URETERAL OBSTRUCTION IN RATS O3.04 Søren Dalager-Pedersen. PERIADVENTITIAL INFLAMMATION - A MARKER OF SYSTEMIC INFLAMMATORY ACTIVATION AND CORONARY DEATH? O3.05 Lars Riisgaard Ribe. MOTION ANALYSIS FOR SHORTER SCAN TIMES IN CARDIAC MRI Oral session O4. Hans Gregersen, Ebba Nexø O4.01 Trine Munk-Olsen. RISK OF POSTPARTUM MENTAL DISORDERS, WOMEN ARE AT RISK, BUT WHAT ABOUT MEN? O4.02 Ellen M. Mikkelsen. PSYCHOSOCIAL CONDITIONS OF WOMEN WHO ANTICIPATE GENETIC COUNSELING: A POPULATION-BASED STUDY O4.03 Karen Johanne Pallesen. EMOTION PROCESSING IN THE HUMAN BRAIN: AN fMRI STUDY O4.04 Brent M. Witgen. INHIBITORY INTERNEURONS FOLLOWING EXPERIMENTAL BRAIN INJURY O4.05 Anita Rethmeier. THE USE OF OLIGONUCLEOTID ARRAYS IN SEARCH OF NEW MOLECULAR MARKERS IN AML Poster session 01. Chairmen: Flemming Winther Bach, Lars Bolund P01.01 Jane Clemmensen. TELEMEDICAL HOME TREATMENT OF PATIENTS WITH DIABETIC FOOT ULCERS: VIDEO PHONE AS A DIAGNOSTIC AID P01.02 Lars Uhrenholt . INJURIES TO THE CERVICAL SPINE FACET JOINTS OF A ROAD TRAFFIC CRASH FATALITY – A CASE REPORT P01.03 Christian Lodberg Hvas. IMPAIRED CYTOKINE RESPONSE IN INTESTINAL CD4+ T CELLS FROM CROHN DISEASE PATIENTS 11 P01.04 Rikke Søgaard. SOCIOECONOMIC EVALUATION OF LUMBAR SPINAL FUSION IN CHRONIC LOW BACK PAIN PATIENTS P01.05 Ashfaque Ahmed Memon. ACTIVITY OF THE EPIDERMAL GROWTH FACTOR RECEPTOR DELAYS THE ONSET OF CALCIUM-INDUCED APOPTOSIS IN BLADDER CANCER CELLS P01.06 Jianguo Chen. STEVIOSIDE DOES NOT CAUSE INCREASED BASAL INSULIN SECRETION OR ß-CELL DESENSITISATION LIKE THE SULPHONYLUREA, GLIBENCLAMIDE: STUDIES IN VITRO P01.07 AnetteTorvin Møller. NEUROPATHIC PAIN AND SENSORY DISTURBANCES IN HETEROZYGOTE PATIENTS WITH FABRY DISEASE P01.08 Mimi Kjærsgaard. TREATMENT OF IDIOPATHIC THROMBOCYTOPENIC PURPURA IN CHILDREN WITH SUBCUTANEOUS ADMINISTERED ANTI-D P01.09 Bodil Øster. HUMAN HERPESVIRUS 6B INDUCES P53 ACCUMULATION AND CELL CYCLE ARREST IN T CELLS P01.10 Anja Fjorback. A ROLE FOR M6B IN THE FUNCTIONAL REGULATION OF THE HUMAN SEROTONIN TRANSPORTER Poster session 02. Chairmen: Jens Overgaard, Gunna Christiansen P02.01 Guixian Wang. DOWNREGULATION OF KEY RENAL ACID BASE TRANSPORT