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® DECEMBER 2012 news ManagingSex LUPUS PLUS Counterfeit Drugs Detecting Sjögren’s and Klinefelter Zoo Endocrinology 01_Cover_Dec2012.indd 1 11/19/12 1:22 PM KRdbts.fpENDO1211_x1a.pdf 1 10/14/12 5:17 PM 02-03 TOC DEC2012.indd 2 11/19/12 1:23 PM KRdbts.fpENDO1211_x1a.pdf 1 10/14/12 5:17 PM DECEMBER 2012 Vol. 37 No. 12 contents NEWS & INSIGHTS FOR THE ENDOCRINE COMMUNITY WWW.ENDO-SOCIETY.ORG Features Departments COVER STORY Systemic Lupus and Hormones 4 ...............................................Viewpoint 16 By Drs. Ida Dzifa Dey, David A. Isenberg, 5 .........................................Editor’s Page Robert G. Lahita, and Cherie Butts Four specialists discuss the impact of endocrine systems on this multifac- 12 ..............................Trends & Insights eted and debilitating autoimmune disease. 28 ...................................Trainee Corner Puzzling Conditions 35 .................................Research Briefs 24By Terri D’Arrigo and Glenda Fauntleroy pg. 16 .............................................Spotlight Like Lupus, the complex symp- 41 toms of Sjögren’s and Klinefelter syndromes make them difficult to 46 ..................................Society Update detect. 49 .................................................Donors Counterfeit Drugs 54 ..........................................Back Story 36By Shannon Fischer When the commercial use of the Internet went global, it opened the 59 .........................................Classifieds floodgates for fake pharmaceuticals. Zoo Fertility Specialist 54By Dan Kelly For Smithsonian Institution’s animal reproductive scientist Janine Brown, pg. 36 endocrinology is critical in the ef- forts to preserve endangered species. DECEMBER 2012 Scan this QR code with your smartphone/mobile NEWS • pg. 54 device for Endocrine News Online. ENDOCRINE 3 02-03 TOC DEC2012.indd 3 11/19/12 1:23 PM VIEWPOINT Those who receive the Early Career Forum Travel Award are also provided with complimentary registration to attend ENDO 2013. The Promotion and Tenure Workshop Travel Awards for junior faculty and mid-career professionals Recognizing Excellence in will also be offered in 2013. These awards provide travel Research, Clinical Practice, support for members early in their careers to attend a workshop that focuses on the skills needed to secure pro- Leadership, and Service motion and/or tenure. Other awards offered include the Early Investigators Awards for early career investigators, Dear Colleagues: the Future Leaders Advancing Research in Endocrinology Program Awards for leadership development training, the The Endocrine Society’s Awards International Endocrine Scholars Awards for international Program is really quite remarkable. trainees, the Minority Access Program Summer Research Each year at ENDO, the Society Awards for undergraduate students from underrepresented presents awards totaling nearly communities, the Medical Student Achievement Awards, $600,000. These awards recognize the Summer Research Fellowship Awards, the Clinical U.S. and internationally based Research Fellowship Award in Acromegaly, the Endocrine William F. Young, Jr. clinical researchers, clinical prac- M.D., M.Sc. Clinical Research Fellowship Awards, and the Endocrinolo- titioners, and basic scientists. The gy and Molecular Endocrinology Student Author Awards. “Awards Call for Nominations” will launch in early January 2013, and I encourage you to nominate your peers, men- Other Awards tors, trainees, and mentees. In this letter, I highlight some The Delbert A. Fisher Research Scholar Award recipient is of the unique aspects of the Society’s Awards Program. recognized for scholarly work on the history of endocrinol- ogy. The awardee will deliver the Clark T. Sawin Memorial Laureate Awards History of Endocrinology Lecture at ENDO 2013 and submit Representing the highest achievement in the field of an article highlighting the presentation for publication in endocrinology, the Laureate Awards honor endocrinologists Endocrine News. Finally, practicing physicians have the whose accomplishments are unmatched in science, leader- opportunity to compete for travel support to ENDO through ship, education, clinical practice, and service. In addition the Harold Vigersky Practicing Physician Travel Award. to the established 11 Laureate Awards, two new awards will The details and application information for these debut in 2013: the International Excellence in Endocri- awards are presented on the Society’s Web site and else- nology Award and the Outstanding Clinical Practitioner where in this and other issues of Endocrine News. Award. Like their predecessors, this year’s Laureate Award recipients will be added to the growing list of distinguished 2013 Election: Reminder, don’t forget to vote! endocrinologists who have made significant contributions This is your opportunity to participate in selecting to improve human health globally. The Laureate Awards the Society’s future leadership. Committee encourages all voting members to contribute to The ballot for the Society’s 2013 election of officers the nomination process beginning in January. and Council will launch in early January 2013. I encour- age you to vote and to remind your colleagues to do the Trainee and Early-Career Awards same. This is your Society, and your participation is vital. For trainees and early-career professionals, the Society The positions on the 2013 ballot are: President-Elect has invested heavily in awards and grants to recognize (Clinical Scientist), Vice President (Physician-in-Practice), their outstanding achievements. In 2012, the Society and Council (one Basic Scientist designated seat and two presented awards to more than 400 trainees. In 2013, At-Large seats.) the Society will continue to offer a robust portfolio of I would like to thank the Nominating Committee trainee- and early-career investigator awards aimed at members for their thoughtful deliberations in selecting encouraging trainees’ continued growth and contribu- an excellent slate of candidates. tions to the Society and the field. Trainees who are both My best wishes for wonderful holidays andy a Happ first and presenting authors of an ENDO 2013 abstract New Year! If you have any comments or questions, please are eligible for the numerous abstract and travel awards. contact me at [email protected]. ■ DECEMBER 2012 In addition, trainee authors of the highest-scoring ab- Sincerely, stracts selected for poster presentation will be invited to NEWS • participate in the Presidential Poster Competition. The Society is pleased to offer continued travel grant support to trainees who wish to attend the ENDO 2013 William F. Young, Jr., M.D. ENDOCRINE Early Career Forum (formerly Endocrine Trainee Day). President, The Endocrine Society 4 04 Viewpoint DEC2012.indd 4 11/19/12 1:24 PM FROM THE EDITOR Endocrine News® is a registered trademark Dear Readers, tating consequences for their owned by The Endocrine Society. fertility (page 24). William F. Young, Jr., M.D. Our bodies’ immune system usually A fascinating story full of warning President protects us from invaders like bacte- is Shannon Fischer’s investigation of [email protected] ria and viruses, but sometimes the counterfeit drug trafficking. As our Teresa K. Woodruff, Ph.D. President-Elect system goes haywire and attacks the global communications via the Inter- [email protected] very organs it should be protecting. net have increased in the last decades, Janet E. Hall, M.D. Autoimmune diseases are frequently the pharmaceuticals market has been Past President hard to diagnose and treatment may inundated with fake medicines. In her [email protected] require a team of specialists, among article, Fischer takes us along as she John C. Marshall, M.D., Ph.D. Secretary-Treasurer them endocrinologists. In this issue, shops online for medications and de- [email protected] four specialists discuss strategies for tails the how-to of the illicit trade and Scott Hunt managing systemic lupus, an autoim- what authorities are doing to stem the Executive Director & CEO mune syndrome that affects multiple tide (page 36). [email protected] body organs and systems. The condi- This month’s Back Story takes us Eleanore Tapscott Senior Director of Publications tion afflicts far more women than men to the zoo. Dan Kelly’s profile of re- [email protected] (page 16). productive physiologist Janine Brown Doug Byrnes Expanding on the problems of auto- tells us how advances in endocrinology Director of Publications immune diseases and perplexing medi- are working to increase populations of [email protected] cal conditions, writers Terri D’Arrigo and endangered animals (page 54). ■ Marian Smith Holmes Managing Editor Glenda Fauntleroy explore two of the [email protected] most baffling to diagnose, Klinefelter Sincerely, Jacqueline Ruttimann, Ph.D. and Sjögren’s syndromes. Sjögren’s, like Associate Editor most autoimmune diseases, usually af- Marian Smith Holmes [email protected] flicts women, but Klinefelter affects Managing Editor Cynthia Richardson Product/Production Manager only men. Although a sleeper condition Endocrine News [email protected] for many men, it usually has devas- touch three Magazine Design & Production www.touch3.com Cenveo Publisher Services Printing & Prepress ENDOCRINE NEWS ONLINE EXCLUSIVES www.cenveo.com The following articles are housed online only. See Endocrine News Online to read them and find related links (www.endo-society.org⁄endo_news). news ® Type O Blood and