January 13, 2015 u vol. 112 u no. 2 u 297–630

Cover image: Pictured is a herd of African forest elephants, Loxodonta cyclotis, foraging in the savanna of La Lopé National Park, Gabon. Jeremy E. Martin et al. analyzed the ele- mental and stable isotopic composition of tooth enamel of forest elephants and 10 other mammal species in the park. The isotope ratios of magnesium, 26Mg/24Mg, were lowest in strict herbivores and highest in omnivorous species. In combination with measurements of barium/calcium ratios and carbon isotopes, measurements of magnesium isotopes may be useful in determining the dietary behavior of fossilized specimens for which dental enamel may be the only material available for analysis. See the article by Martin et al. on pages 430– 435. Image courtesy of Estel Sarroca (photographer). From the Cover

430 Mammalian diet and magnesium isotope ratios E110 Counting proteins with super-resolution microscopy 332 Ocean carbon cycling and climate change 458 Human adaptation to ethanol 500 Antibody similarities in twins

Contents RETROSPECTIVE

302 Max Birnstiel 1933–2014: Gene pioneer Michael Grunstein and Adrian Bird THIS WEEK IN PNAS

297 In This Issue COMMENTARIES

304 A promising approach to molecular counting problem LETTERS (ONLINE ONLY) in superresolution microscopy Jin Wang See companion article on page E110 E99 Simple chained guide trees give poorer multiple sequence alignments than inferred trees in simulation 306 Ironing out carbon export to the deep ocean and phylogenetic benchmarks Ingrid L. Hendy Ge Tan, Manuel Gil, Ari P. Löytynoja, Nick Goldman, See companion article on page 332 and Christophe Dessimoz 308 Ferment in the family tree E101 Reply to Tan et al.: Differences between real and Nathaniel J. Dominy simulated proteins in multiple sequence alignments See companion article on page 458 Kieran Boyce, Fabian Sievers, and Desmond G. Higgins E102 Should we “reef” obsolete oil platforms? PNAS PLUS Ashley M. Fowler, Peter I. Macreadie, and David J. Booth 310 Significance Statements Brief statements written by the authors about the significance of their papers. NEWS FEATURE—An in-depth look at trending science issues

299 News Feature: The search for what sets humans apart PERSPECTIVE Robert Frederick 313 A generation at risk: Young investigators and the future of the biomedical workforce Free online through the PNAS open access option. Ronald J. Daniels

PNAS u January 13, 2015 u vol. 112 u no. 2 u iii–vii Downloaded by guest on September 26, 2021 SOCIAL SCIENCES INAUGURAL ARTICLE 354 Cohort of birth modifies the association between FTO genotype and BMI 319 Kinetic pathway of 40S ribosomal subunit recruitment to James Niels Rosenquist, Steven F. Lehrer, A. James hepatitis C virus internal ribosome entry site O’Malley, Alan M. Zaslavsky, Jordan W. Smoller, Gabriele Fuchs, Alexey N. Petrov, Caleb D. Marceau, and Nicholas A. Christakis Lauren M. Popov, Jin Chen, Seán E. O’Leary, Richard Wang, Jan E. Carette, Peter Sarnow, and Joseph D. Puglisi 360 Measuring the effectiveness of scientific gatekeeping Kyle Siler, Kirby Lee, and Lisa Bero PHYSICAL SCIENCES BIOLOGICAL SCIENCES CHEMISTRY

326 Energetic basis for the molecular-scale organization ANTHROPOLOGY of bone Jinhui Tao, Keith C. Battle, Haihua Pan, E. Alan 366 Recent origin of low trabecular bone density in Salter, Yung-Ching Chien, Andrzej Wierzbicki, modern humans and James J. De Yoreo Habiba Chirchir, Tracy L. Kivell, Christopher B. Ruff, Jean-Jacques Hublin, Kristian J. Carlson, Bernhard Zipfel, and Brian G. Richmond EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 332 Climate change decouples oceanic primary and export 372 Gracility of the modern Homo sapiens skeleton is the productivity and organic carbon burial result of decreased biomechanical loading Cristina Lopes, Michal Kucera, and Alan C. Mix Timothy M. Ryan and Colin N. Shaw See Commentary on page 306 APPLIED BIOLOGICAL SCIENCES 336 Carbonate formation events in ALH 84001 trace the evolution of the Martian atmosphere 378 Detecting nanoscale vibrations as signature of life Robina Shaheen, Paul B. Niles, Kenneth Chong, Catherine M. Sandor Kasas, Francesco Simone Ruggeri, Carine Benadiba, Corrigan, and Mark H. Thiemens Caroline Maillard, Petar Stupar, Hélène Tournu, Giovanni Dietler, and Giovanni Longo 430 Magnesium stable isotope ecology using mammal tooth enamel BIOCHEMISTRY Jeremy E. Martin, Derek Vance, and Vincent Balter 382 Structure of the Pseudomonas aeruginosa 436 Effect of increasing CO2 on the terrestrial transamidosome reveals unique aspects of carbon cycle bacterial tRNA-dependent asparagine biosynthesis David Schimel, Britton B. Stephens, and Joshua B. Fisher Tateki Suzuki, Akiyoshi Nakamura, Koji Kato, Dieter Söll, Isao Tanaka, Kelly Sheppard, and Min Yao ENGINEERING 388 Crystal structures of alkylperoxo and anhydride E103 Oxidation-driven surface dynamics on NiAl(100) intermediates in an intradiol ring-cleaving dioxygenase Hailang Qin, Xidong Chen, Liang Li, Peter W. Sutter, Cory J. Knoot, Vincent M. Purpero, and John D. Lipscomb and Guangwen Zhou 394 Mechanism by which a recently discovered allosteric 378 Detecting nanoscale vibrations as signature of life inhibitor blocks glutamine metabolism in Sandor Kasas, Francesco Simone Ruggeri, Carine Benadiba, transformed cells Caroline Maillard, Petar Stupar, Hélène Tournu, Giovanni Clint A. Stalnecker, Scott M. Ulrich, Yunxing Li, Dietler, and Giovanni Longo Sekar Ramachandran, Mary Kate McBrayer, Ralph J. DeBerardinis, Richard A. Cerione, and Jon W. Erickson PHYSICS 400 Human mutations in methylenetetrahydrofolate 342 Granular impact cratering by liquid drops: dehydrogenase 1 impair nuclear de novo Understanding raindrop imprints through an thymidylate biosynthesis analogy to asteroid strikes Martha S. Field, Elena Kamynina, David Watkins, Runchen Zhao, Qianyun Zhang, Hendro Tjugito, David S. Rosenblatt, and Patrick J. Stover and Xiang Cheng BIOPHYSICS AND COMPUTATIONAL BIOLOGY SOCIAL SCIENCES E110 Stochastic approach to the molecular counting problem in superresolution microscopy ANTHROPOLOGY Geoffrey C. Rollins, Jae Yen Shin, Carlos Bustamante, and Steve Pressé 348 Warfare and reproductive success in a tribal population See Commentary on page 304 Luke Glowacki and Richard Wrangham E119 Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, PSYCHOLOGICAL AND COGNITIVE SCIENCES in lipid bilayers 619 Direct coupling of haptic signals between hands Nabanita Das, Jian Dai, Ivan Hung, Malini R. Rajagopalan, Lucile Dupin, Vincent Hayward, and Mark Wexler Huan-Xiang Zhou, and Timothy A. Cross

iv u www.pnas.org Downloaded by guest on September 26, 2021 E127 β-Helical architecture of cytoskeletal bactofilin filaments 448 Experiment, monitoring, and gradient methods used to revealed by solid-state NMR infer climate change effects on plant communities yield Suresh Vasa, Lin Lin, Chaowei Shi, Birgit Habenstein, consistent patterns Dietmar Riedel, Juliane Kühn, Martin Thanbichler, Sarah C. Elmendorf, Gregory H. R. Henry, Robert D. and Adam Lange Hollister, Anna Maria Fosaa, William A. Gould, Luise Hermanutz, Annika Hofgaard, Ingibjörg I. Jónsdóttir, 319 Kinetic pathway of 40S ribosomal subunit recruitment to Janet C. Jorgenson, Esther Lévesque, Borgþór Magnusson, hepatitis C virus internal ribosome entry site Ulf Molau, Isla H. Myers-Smith, Steven F. Oberbauer, Gabriele Fuchs, Alexey N. Petrov, Caleb D. Marceau, Christian Rixen, Craig E. Tweedie, and Marilyn Walker Lauren M. Popov, Jin Chen, Seán E. O’Leary, Richard Wang, Jan E. Carette, Peter Sarnow, and Joseph D. Puglisi ENVIRONMENTAL SCIENCES 406 Bacterial growth laws reflect the evolutionary importance of energy efficiency 332 Climate change decouples oceanic primary and export Arijit Maitra and Ken A. Dill productivity and organic carbon burial Cristina Lopes, Michal Kucera, and Alan C. Mix See Commentary on page 306 CELL BIOLOGY 412 Remodeling of intermediate metabolism in the 453 Cryptic carbon and sulfur cycling between surface diatom Phaeodactylum tricornutum under ocean plankton nitrogen stress Bryndan P. Durham, Shalabh Sharma, Haiwei Luo, Christa B. Orly Levitan, Jorge Dinamarca, Ehud Zelzion, Smith, Shady A. Amin, Sara J. Bender, Stephen P. Dearth, Desmond S. Lun, L. Tiago Guerra, Min Kyung Kim, Benjamin A. S. Van Mooy, Shawn R. Campagna, Joomi Kim, Benjamin A. S. Van Mooy, Debashish Elizabeth B. Kujawinski, E. Virginia Armbrust, Bhattacharya, and Paul G. Falkowski and Mary Ann Moran 418 Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum EVOLUTION Shuliang Chen, Tanvi Desai, James A. McNew, Patrick 458 Hominids adapted to metabolize ethanol long before Gerard, Peter J. Novick, and Susan Ferro-Novick human-directed fermentation Matthew A. Carrigan, Oleg Uryasev, Carole B. Frye, Blair L. DEVELOPMENTAL BIOLOGY Eckman, Candace R. Myers, Thomas D. Hurley, E137 β-Catenin–related protein WRM-1 is a multifunctional and Steven A. Benner regulatory subunit of the LIT-1 MAPK complex See Commentary on page 308 Xiao-Dong Yang, Tejas R. Karhadkar, Jessica Medina, 464 Pan-vertebrate comparative genomics unmasks Scott M. Robertson, and Rueyling Lin retrovirus macroevolution 424 Fnip1 regulates skeletal muscle fiber type Alexander Hayward, Charlie K. Cornwallis, specification, fatigue resistance, and susceptibility and Patric Jern to muscular dystrophy 470 Directional selection can drive the evolution of Nicholas L. Reyes, Glen B. Banks, Mark Tsang, modularity in complex traits Daciana Margineantu, Haiwei Gu, Danijel Djukovic, Diogo Melo and Gabriel Marroig Jacky Chan, Michelle Torres, H. Denny Liggitt, Dinesh K. Hirenallur-S, David M. Hockenbery, Daniel Raftery, and Brian M. Iritani GENETICS 354 Cohort of birth modifies the association between FTO ECOLOGY genotype and BMI 430 Magnesium stable isotope ecology using mammal James Niels Rosenquist, Steven F. Lehrer, A. James ’ tooth enamel O Malley, Alan M. Zaslavsky, Jordan W. Smoller, and Nicholas A. Christakis Jeremy E. Martin, Derek Vance, and Vincent Balter

436 Effect of increasing CO2 on the terrestrial carbon cycle IMMUNOLOGY AND INFLAMMATION David Schimel, Britton B. Stephens, and Joshua B. Fisher E147 Immunological consequences of intragenus conservation of Mycobacterium tuberculosis 442 The global distribution of diet breadth in T-cell epitopes insect herbivores Cecilia S. Lindestam Arlehamn, Sinu Paul, Federico Mele, Matthew L. Forister, Vojtech Novotny, Anna K. Panorska, Charlie Huang, Jason A. Greenbaum, Randi Vita, Leontine Baje, Yves Basset, Philip T. Butterill, Lukas Cizek, John Sidney, Bjoern Peters, Federica Sallusto, Phyllis D. Coley, Francesca Dem, Ivone R. Diniz, Pavel and Alessandro Sette Drozd, Mark Fox, Andrea E. Glassmire, Rebecca Hazen, Jan Hrcek, Joshua P. Jahner, Ondrej Kaman, Tomasz J. E156 Polymeric synthetic nanoparticles for the induction of Kozubowski, Thomas A. Kursar, Owen T. Lewis, John Lill, antigen-specific immunological tolerance Robert J. Marquis, Scott E. Miller, Helena C. Morais, Masashi Roberto A. Maldonado, Robert A. LaMothe, Joseph D. Murakami, Herbert Nickel, Nicholas A. Pardikes, Robert E. Ferrari, Ai-Hong Zhang, Robert J. Rossi, Pallavi N. Kolte, Ricklefs, Michael S. Singer, Angela M. Smilanich, John O. Aaron P. Griset, Conlin O’Neil, David H. Altreuter, Erica Stireman, Santiago Villamarín-Cortez, Stepan Vodka, Martin Browning, Lloyd Johnston, Omid C. Farokhzad, Robert Volf, David L. Wagner, Thomas Walla, George D. Weiblen, Langer, David W. Scott, Ulrich H. von Andrian, and Lee A. Dyer and Takashi Kei Kishimoto

PNAS u January 13, 2015 u vol. 112 u no. 2 u v Downloaded by guest on September 26, 2021 E166 HLA ligandome analysis identifies the underlying MEDICAL SCIENCES specificities of spontaneous antileukemia immune 530 MSCs derived from iPSCs with a modified protocol are responses in chronic lymphocytic leukemia (CLL) tumor-tropic but have much less potential to promote Daniel J. Kowalewski, Heiko Schuster, Linus Backert, Claudia tumors than bone marrow MSCs Berlin, Stefan Kahn, Lothar Kanz, Helmut R. Salih, Qingguo Zhao, Carl A. Gregory, Ryang Hwa Lee, Roxanne L. Hans-Georg Rammensee, Stefan Stevanovic, Reger, Lizheng Qin, Bo Hai, Min Sung Park, Nara Yoon, and Juliane Sarah Stickel Bret Clough, Eoin McNeill, Darwin J. Prockop, + 476 miR-155 augments CD8 T-cell antitumor activity in and Fei Liu lymphoreplete hosts by enhancing responsiveness to 536 Inhibition of soluble epoxide hydrolase modulates homeostatic γ cytokines c inflammation and autophagy in obese adipose tissue Yun Ji, Claudia Wrzesinski, Zhiya Yu, Jinhui Hu, Sanjivan and liver: Role for omega-3 epoxides Gautam, Nga V. Hawk, William G. Telford, Douglas C. Cristina López-Vicario, José Alcaraz-Quiles, Verónica Palmer, Zulmarie Franco, Madhusudhanan Sukumar, Rahul García-Alonso, Bibiana Rius, Sung H. Hwang, Esther Titos, Roychoudhuri, David Clever, Christopher A. Klebanoff, Aritz Lopategi, Bruce D. Hammock, Vicente Arroyo, Charles D. Surh, Thomas A. Waldmann, Nicholas P. Restifo, and Joan Clària and Luca Gattinoni 542 A red meat-derived glycan promotes inflammation and 482 Appearance and disappearance of the mRNA signature cancer progression characteristic of T cells in visceral adipose tissue: Age, reg Annie N. Samraj, Oliver M. T. Pearce, Heinz Läubli, Alyssa N. diet, and PPARγ effects Crittenden, Anne K. Bergfeld, Kalyan Banda, Christopher J. Daniela Cipolletta, Paul Cohen, Bruce M. Spiegelman, Gregg, Andrea E. Bingman, Patrick Secrest, Sandra L. Diaz, Christophe Benoist, and Diane Mathis Nissi M. Varki, and Ajit Varki 488 Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization MICROBIOLOGY Catherine A. Fromen, Gregory R. Robbins, Tammy W. Shen, E176 Antiviral immunity of Anopheles gambiae is highly Marc P. Kai, Jenny P. Y. Ting, and Joseph M. DeSimone compartmentalized, with distinct roles for RNA 494 Intracellular osteopontin regulates homeostasis and interference and gut microbiota function of natural killer cells Guillaume Carissimo, Emilie Pondeville, Melanie McFarlane, Jianmei W. Leavenworth, Bert Verbinnen, Qin Wang, Isabelle Dietrich, Christian Mitri, Emmanuel Bischoff, Erxia Shen, and Harvey Cantor Christophe Antoniewski, Catherine Bourgouin, Anna-Bella Failloux, Alain Kohl, and Kenneth D. Vernick 500 B-cell repertoire responses to varicella-zoster vaccination in human identical twins E186 The polarity of myxobacterial gliding is regulated by Chen Wang, Yi Liu, Mary M. Cavanagh, Sabine Le Saux, Qian direct interactions between the gliding motors and the Qi, Krishna M. Roskin, Timothy J. Looney, Ji-Yeun Lee, Ras homolog MglA Vaishali Dixit, Cornelia L. Dekker, Gary E. Swan, Jörg J. Beiyan Nan, Jigar N. Bandaria, Kathy Y. Guo, Xue Fan, Goronzy, and Scott D. Boyd Amirpasha Moghtaderi, Ahmet Yildiz, and David R. Zusman

506 Hematopoietic IKBKE limits the chronicity of E194 Tracking heavy water (D2O) incorporation for inflammasome priming and metaflammation identifying and sorting active microbial cells Meghana N. Patel, William G. Bernard, Nikolay B. Milev, David Berry, Esther Mader, Tae Kwon Lee, Dagmar William P. Cawthorn, Nichola Figg, Dan Hart, Xavier Prieur, Woebken, Yun Wang, Di Zhu, Marton Palatinszky, Arno Sam Virtue, Krisztina Hegyi, Stephanie Bonnafous, Beatrice Schintlmeister, Markus C. Schmid, Buck T. Hanson, Naama Bailly-Maitre, Yajing Chu, Julian L. Griffin, Ziad Mallat, Shterzer, Itzhak Mizrahi, Isabella Rauch, Thomas Decker, Robert V. Considine, Albert Tran, Philippe Gual, Osamu Thomas Bocklitz, Jürgen Popp, Christopher M. Gibson, Takeuchi, Shizuo Akira, Antonio Vidal-Puig, Martin R. Patrick W. Fowler, Wei E. Huang, and Michael Wagner Bennett, and Jaswinder K. Sethi 548 Evolution of the H9N2 influenza genotype that 512 Inducible RNAi in vivo reveals that the transcription facilitated the genesis of the novel H7N9 virus factor BATF is required to initiate but not maintain CD8+ Juan Pu, Shuoguo Wang, Yanbo Yin, Guozhong Zhang, T-cell effector differentiation Robert A. Carter, Jinliang Wang, Guanlong Xu, Honglei Sun, Jernej Godec, Glenn S. Cowley, R. Anthony Barnitz, David E. Min Wang, Chu Wen, Yandi Wei, Dongdong Wang, Baoli Root, Arlene H. Sharpe, and W. Nicholas Haining Zhu, Gordon Lemmon, Yuannian Jiao, Susu Duan, Qian + + Wang, Qian Du, Meng Sun, Jinnan Bao, Yipeng Sun, 518 Activated CD4 CCR5 T cells in the rectum predict Jixun Zhao, Hui Zhang, Gang Wu, Jinhua Liu, increased SIV acquisition in SIVGag/Tat-vaccinated and Robert G. Webster rhesus macaques Diane G. Carnathan, Katherine S. Wetzel, Joana Yu, S. Thera 554 Epstein–Barr virus nuclear antigen 3A partially coincides Lee, Brent A. Johnson, Mirko Paiardini, Jian Yan, Matthew P. with EBNA3C genome-wide and is tethered to DNA Morrow, Niranjan Y. Sardesai, David B. Weiner, through BATF complexes Hildegund C. J. Ertl, and Guido Silvestri Stefanie C. S. Schmidt, Sizun Jiang, Hufeng Zhou, Bradford Willox, Amy M. Holthaus, Peter V. Kharchenko, Eric C. 524 CTLA-4 controls follicular helper T-cell differentiation by Johannsen, Elliott Kieff, and Bo Zhao regulating the strength of CD28 engagement Chun Jing Wang, Frank Heuts, Vitalijs Ovcinnikovs, Lukasz 560 Direct measurement of oxidative and nitrosative stress Wardzinski, Chantelle Bowers, Emily M. Schmidt, Alexandros dynamics in Salmonella inside macrophages Kogimtzis, Rupert Kenefeck, David M. Sansom, Joris van der Heijden, Else S. Bosman, Lisa A. Reynolds, and Lucy S. K. Walker and B. Brett Finlay

vi u www.pnas.org Downloaded by guest on September 26, 2021 566 The chemistry of negotiation: Rhythmic, glycan-driven 607 Coral host cells acidify symbiotic algal microenvironment acidification in a symbiotic conversation to promote photosynthesis Julia A. Schwartzman, Eric Koch, Elizabeth A. C. Katie L. Barott, Alexander A. Venn, Sidney O. Perez, Heath-Heckman, Lawrence Zhou, Natacha Kremer, Sylvie Tambutté, and Martin Tresguerres Margaret J. McFall-Ngai, and Edward G. Ruby 572 Dialkylresorcinols as bacterial signaling molecules PLANT BIOLOGY Sophie Brameyer, Darko Kresovic, Helge B. Bode, 613 Nitric oxide negatively regulates abscisic acid signaling in and Ralf Heermann guard cells by S-nitrosylation of OST1 Pengcheng Wang, Yanyan Du, Yueh-Ju Hou, Yang Zhao, Chuan-Chih Hsu, Feijuan Yuan, Xiaohong Zhu, W. Andy NEUROSCIENCE Tao, Chun-Peng Song, and Jian-Kang Zhu E204 Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus PSYCHOLOGICAL AND COGNITIVE SCIENCES Matildé Le Bail, Magalie Martineau, Silvia Sacchi, Natalia E230 Extinction learning, which consists of the inhibition of Yatsenko, Inna Radzishevsky, Sandrine Conrod, Karima retrieval, can be learned without retrieval Ait Ouares, Herman Wolosker, Loredano Pollegioni, Jociane de Carvalho Myskiw, Cristiane Regina Guerino Jean-Marie Billard, and Jean-Pierre Mothet Furini, Bianca Schmidt, Flávia Ferreira, and Ivan Izquierdo

E214 Differential roles of delay-period neural activity in the 619 Direct coupling of haptic signals between hands monkey dorsolateral prefrontal cortex in visual–haptic Lucile Dupin, Vincent Hayward, and Mark Wexler crossmodal working memory Liping Wang, Xianchun Li, Steven S. Hsiao, Fred A. Lenz, 625 Enhancing long-term memory with stimulation tunes Mark Bodner, Yong-Di Zhou, and Joaquín M. Fuster visual attention in one trial Robert M. G. Reinhart and Geoffrey F. Woodman E220 Sensory determinants of behavioral dynamics in Drosophila thermotaxis Mason Klein, Bruno Afonso, Ashley J. Vonner, Luis Hernandez-Nunez, Matthew Berck, Christopher J. Tabone, CORRECTIONS (ONLINE ONLY) Elizabeth A. Kane, Vincent A. Pieribone, Michael N. Nitabach, Albert Cardona, Marta Zlatic, Simon G. OPINION Sprecher, Marc Gershow, Paul A. Garrity, and Aravinthan D. T. Samuel E234 Opinion: Mathematical models: A key tool for outbreak response 578 Distinct dopamine neurons mediate reward signals for Eric Lofgren, M. Elizabeth Halloran, C. M. Rivers, short- and long-term memories J. M. Drake, Travis C. Porco, Bryan Lewis, Wan Yang, Nobuhiro Yamagata, Toshiharu Ichinose, Yoshinori Alessandro Vespignani, Jeffrey Shaman, Joseph N. S. Aso, Pierre-Yves Plaçais, Anja B. Friedrich, Eisenberg, M. C. Eisenberg, Madhav Marathe, Samuel V. Richard J. Sima, Thomas Preat, Gerald M. Scarpino, Kathleen A. Alexander, Rafael Meza, Matthew J. Rubin, and Hiromu Tanimoto Ferrari, James M. Hyman, Lauren A. Meyers, and Stephen Eubank 584 Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep Christa J. Van Dort, Daniel P. Zachs, Jonathan D. COLLOQUIUM Kenny, Shu Zheng, Rebecca R. Goldblum, Noah A. E235 Genomic imprinting and the evolutionary psychology of Gelwan, Daniel M. Ramos, Michael A. Nolan, human kinship Karen Wang, Feng-Ju Weng, Yingxi Lin, Matthew A. David Haig Wilson, and Emery N. Brown

590 G protein-coupled odorant receptors underlie BIOCHEMISTRY mechanosensitivity in mammalian olfactory E236 Combinatorial regulation of a signal-dependent sensory neurons activator by phosphorylation and acetylation Timothy Connelly, Yiqun Yu, Xavier Grosmaitre, Jue Wang, Jose C. Paz, Sang-Ho Park, Naomi Phillips, Shigenobu Lindsey C. Santarelli, Agnes Savigner, Xin Qiao, Zhenshan Matsumura, Wen-Wei Tsai, Lawryn Kasper, Paul K. Brindle, Wang, Daniel R. Storm, and Minghong Ma Guangtao Zhang, Ming-Ming Zhou, Peter E. Wright, 596 Enhancement of a robust arcuate GABAergic input to and Marc Montminy gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome ENVIRONMENTAL SCIENCES Aleisha M. Moore, Mel Prescott, Christopher J. Marshall, Siew Hoong Yip, and Rebecca E. Campbell E237 The commonly used antimicrobial additive triclosan is a liver tumor promoter Mei-Fei Yueh, Koji Taniguchi, Shujuan Chen, Ronald M. PHYSIOLOGY Evans, Bruce D. Hammock, Michael Karin, 602 Stac adaptor proteins regulate trafficking and function and Robert H. Tukey + of muscle and neuronal L-type Ca2 channels Alexander Polster, Stefano Perni, Hicham Bichraoui, and Kurt G. Beam ix Subscription Form

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