VASCULAR DISORDERS INTRODUCTION the Term Vascular
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Deep Vein Thrombosis in Behcet's Disease
BRIEF PAPER Clinical and Experimental Rheumatology 2001; 19 (Suppl. 24): S48-S50. Deep vein thrombosis ABSTRACT stitute the most frequent vascular mani- Objective festation seen in 6.2 to 33 % cases of in Behcet’s disease We aimed to describe the epidemiologi - BD (1, 2). We carried out this study to cal and clinical aspects of deep vein d e t e rmine the fre q u e n cy, the cl i n i c a l M.H. Houman1 thrombosis (DVT) in Behçet’s disease characteristics and course of deep vein 1 (BD) and to determine the patients at thrombosis (DVT) in BD patients and I. Ben Ghorbel high risk for this complication. to define a subgroup of patients at high I. Khiari Ben Salah1 Methods risk for this complication. M. Lamloum1 Among 113 patients with BD according 2 to the international criteria for classifi - Patients and methods M. Ben Ahmed cation of BD, those with DVT were ret - The medical records of one hundred M. Miled1 rospectively studied.The diagnosis of and thirteen patients with BD were re- DVT was made in all cases using con - viewed in order to investigate the pa- 1Department of Internal Medicine. La ventional venous angiography, venous tient’s medical history, the clinical ma- Rabta Hospital, 2Department of Immuno- ultrasonography and/or thoracic or ab - nifestations and outcome of the disease logy, Institute Pasteur. Tunis, Tunisia. dominal computed tomograp hy. Pa - as well as the treatment prescribed.The Houman M Habib, MD; Ben Ghorbel tients were divided in two subgroups diagnosis of BD was made based on the Imed, MD; Khiari Ben Salah Imen; a c c o rding to the occurrence of DV T criteria established by the international Lamloum Mounir, MD; Ben Ahmed other than cereb ral thromboses. -
High B1a0d Pressure and Its Treatment in General
HIGH B1A0D PRESSURE AND ITS TREATMENT IN GENERAL PRACTICE WITH PARTICULAR REFERENCE TO A SERIES OF 100 CASES TREATED BY THE AUTHOR By HAROLD WILSON B01YBR IB.ffh.B. ProQuest Number: 13849841 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a com plete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. uest ProQuest 13849841 Published by ProQuest LLC(2019). Copyright of the Dissertation is held by the Author. All rights reserved. This work is protected against unauthorized copying under Title 17, United States C ode Microform Edition © ProQuest LLC. ProQuest LLC. 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106- 1346 -CONTENTS SECTION 1. Introduction. SECTION 2. General Remarks. Definitions of General Interest. Present Views on Etiology. Pathology and Morbid Anatomy. Brief Historical Survey. SECTION 3. The Present Position. Prevalence. Clinical Manifestations. Prognosis. SECTION 4. Prevalence in Bolton. Summary of Cases. Symptomatology and Case Histories Prognosis. Treatment. SECTION 5. Conclusions. Bibliography. SECTION 1. INTRODUCTION. I think it can truthfully be said that the most interest ing problems in Medioine are those that are most baffling. Some years ago Ralph M a j o r ^ wrote these words, ”If our knowledge of the etiology of arterial hypertension is shrouded in a oertain haze, our knowledge of an effective therapy in this disease is enveloped in a dense fog.n A study of some of the vast literature on this subject does not greatly clarify the obscurity. -
441.2.Full.Pdf
Ann Rheum Dis: first published as 10.1136/annrheumdis-2018-eular.4790 on 12 June 2018. Downloaded from Scientific Abstracts Thursday, 14 June 2018 441 All GCA TAK p (n 23) (n 13) (n 8) Female, n (%) 19 (82.6) 12 (92.3) 6 (75) ns Age at diagnosis 63 (51–68) 68 (63–73) 43.5 (30.5–57) 0.003 Diagnostic latency (months) 4.5 (2–12) 3 (2–10) 8 (3.5–12) ns ESR at disease onset (mm/h) 49 (38–68) 52.5 (45.5– 42 (40–61.5) ns 59.7) CRP at disease onset (mg/L) 61.8 (13– 89 (32.5–106) 60.5 (9.3–132.5) ns 132.5) Disease duration at PET/MR 27 (18–36) 24 (13–29.5) 36.5 (14.75– ns (months) 129.3) ESR at examination (mm/h) 18 (9–35) 16 (7–31) 20.5 (11–44.5) ns CRP at examination (mg/L) 4.5 (2.55–8.9) 3.9 (3.48–4.72) 4.55 (2.05–10.4) ns Results: 23 LVV patients were included, 56.5% GCA, 34.8% TAK and 8.7% iso- Results: Among 602 patients with TA during this period, 119 (19.8%) were jTA, lated aortitis, all Caucasian, mostly females (82%). We considered 55 PET scans, while 483 were aTA. Female predominance was less striking in jTA (71.4%) than 32/55 in LVV group (from min. 1 to max. 3 scans/patient) mainly during follow-up aTA (79%), p=0.047. Patients with jTA had presented more commonly with fever (29/32 scans), and 23/55 in control group. -
Peripheral Vascular Disease (PVD) Fact Sheet
FACT SHEET FOR PATIENTS AND FAMILIES Peripheral Vascular Disease (PVD) What is peripheral vascular disease? Vascular disease is disease of the blood vessels (arteries and veins). Peripheral vascular disease (PVD) affects The heart receives blood, the areas that are “peripheral,” or outside your heart. sends it to The most common types of PVD are: the lungs to get oxygen, • Carotid artery disease affects the arteries and pumps that carry blood to your brain. It occurs when it back out. one or more arteries are narrowed or blocked by plaque, a fatty substance that builds up inside artery walls. Carotid artery disease can increase Veins carry Arteries carry your risk of stroke. It can also cause transient blood to your oxygen-rich [TRANZ-ee-ent] ischemic [iss-KEE-mik] attacks (TIAs). heart to pick blood from up oxygen. your heart TIAs are temporary changes in brain function to the rest of that are sometimes called “mini-strokes.” your body. • Peripheral arterial disease (PAD) often affects the arteries to your legs and feet. It is also caused by Healthy blood vessels provide oxygen plaque buildup, and can for every part of your body. cause pain that feels like a dull cramp or heavy tiredness in your hips or legs when • Venous insufficiency affects the veins, usually you exercise or climb stairs. in your legs or feet. Your veins have valves that This pain is sometimes Damaged Healthy keepvalve blood fromvalve flowing backward as it moves called claudication. If PAD toward your heart. If the valves stop working, blood worsens, it can cause cold Plaque can build backs up in your body, usually in your legs. -
Aortic Thrombus Causing a Hypertensive Emergency
CASE REPORT Aortic Thrombus Causing a Hypertensive Emergency Kraftin E. Schreyer, MD*† *Temple University Hospital, Department of Emergency Medicine, Philadelphia, Jenna Otter, MD* Pennsylvania Zachary Johnston, BS† †Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania Section Editor: Rick A. McPheeters, DO Submission history: Submitted February 9, 2017; Revision received June 27, 2017; Accepted June 28, 2017 Electronically published November 3, 2017 Full text available through open access at http://escholarship.org/uc/uciem_cpcem DOI: 10.5811/cpcem.2017.6.33876 Thoracic aorta thrombi are a rare condition typically presenting as a source for distal embolization in elderly patients with atherosclerotic risk factors. However, young patients with a variety of presentations resulting from such thrombi have rarely been reported. We describe a case of a young patient with refractory hypertensive emergency caused by a large thoracic aorta thrombus. Investigation was guided by abnormal physical exam findings. [Clin Pract Cases Emerg Med.2017;1(4):387–390.] INTRODUCTION supine positioning. It had progressively worsened over the Thoracic aorta thrombi are exceedingly rare. When they course of one day and was associated with chest pain, do occur, they typically present as a source of distal subjective fever, and cough productive of blood-tinged embolization, clinically resulting in stroke, transient sputum. According to the patient, he had experienced similar ischemic attack, or arterial embolization of an extremity. symptoms when he was diagnosed with PJP pneumonia. Diagnosis of thoracic aorta thrombi is often made in older On initial exam, the patient had a blood pressure (BP) of patients with atherosclerotic risk factors or known 247/128 mmHg, pulse of 135 beats per minute, and an aneurysmal or atherosclerotic disease.1,2 Thrombi have also oxygen saturation of 86% on room air. -
Echocardiography in Pediatric Pulmonary Hypertension
REVIEW ARTICLE published: 12 November 2014 PEDIATRICS doi: 10.3389/fped.2014.00124 Echocardiography in pediatric pulmonary hypertension Pei-Ni Jone* and D. Dunbar Ivy Pediatric Cardiology, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA Edited by: Pulmonary hypertension (PH) can be a rapidly progressive and fatal disease. Although Antonio Francesco Corno, Universiti right heart catheterization remains the gold standard in evaluation of PH, echocardiogra- Sains Malaysia, Malaysia phy remains an important tool in screening, diagnosing, evaluating, and following these Reviewed by: Jeffrey Feinstein, Stanford University, patients. In this article, we will review the important echocardiographic parameters of the USA right heart in evaluating its anatomy, hemodynamic assessment, systolic, and diastolic Cecile Tissot, The University function in children with PH. Children’s Hospital, Switzerland Tilman Humpl, SickKids Hospital, Keywords: pediatric pulmonary hypertension, echocardiography, right heart, right ventricular function Canada *Correspondence: Pei-Ni Jone, Pediatric Cardiology, Children’s Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO 80045, USA e-mail: pei-ni.jone@ childrenscolorado.org INTRODUCTION of the RA area in end-systole is performed to evaluate for RA dila- Pulmonary hypertension (PH) is a progressive disease that carries tion (Figure 1)(3). Indexed RA area to body surface area in adult high morbidity and mortality. Although cardiac catheterization is patients with idiopathic PH has been a predictor of mortality and used to define PH, echocardiography is the most important non- has been shown to be a prognostic marker for follow up of PH invasive tool that is used to detect PH (1). -
What Is Dvt? Deep Vein Thrombosis (DVT) Occurs When an Abnormal Blood Clot Forms in a Large Vein
What is DVt? Deep vein thrombosis (DVT) occurs when an abnormal blood clot forms in a large vein. These clots usually develop in the lower leg, thigh, or pelvis, but can also occur in other large veins in the body. If you develop DVT and it is diagnosed correctly and quickly, it can be treated. However, many people do not know if they are at risk, don’t know the symptoms, and delay seeing a healthcare professional if they do have symptoms. CAn DVt hAppen to me? Anyone may be at risk for DVT but the more risk factors you have, the greater your chances are of developing DVT. Knowing your risk factors can help you prevent DVt: n Hospitalization for a medical illness n Recent major surgery or injury n Personal history of a clotting disorder or previous DVT n Increasing age this is serious n Cancer and cancer treatments n Pregnancy and the first 6 weeks after delivery n Hormone replacement therapy or birth control products n Family history of DVT n Extended bed rest n Obesity n Smoking n Prolonged sitting when traveling (longer than 6 to 8 hours) DVt symptoms AnD signs: the following are the most common and usually occur in the affected limb: n Recent swelling of the limb n Unexplained pain or tenderness n Skin that may be warm to the touch n Redness of the skin Since the symptoms of DVT can be similar to other conditions, like a pulled muscle, this often leads to a delay in diagnosis. Some people with DVT may have no symptoms at all. -
A Comprehensive Study on Incidence and Risk Factors of Deep Vein Thrombosis in Asymptomatic Patient After Prolonged Surgery
D. Princess Beulah, T. Avvai. A comprehensive study on incidence and risk factors of deep vein thrombosis in asymptomatic patient after prolonged surgery. IAIM, 2019; 6(3): 237-242. Original Research Article A comprehensive study on incidence and risk factors of deep vein thrombosis in asymptomatic patient after prolonged surgery D. Princess Beulah1, T. Avvai2* 1Assistant Professor, Department of General Surgery, Govt. Stanley Medical College, Tamil Nadu, India 2Associate Professor, Department of General Surgery, Govt. Omandurar Medical College and Hospital, Tamil Nadu, India *Corresponding author email: [email protected] International Archives of Integrated Medicine, Vol. 6, Issue 3, March, 2019. Copy right © 2019, IAIM, All Rights Reserved. Available online at http://iaimjournal.com/ ISSN: 2394-0026 (P) ISSN: 2394-0034 (O) Received on: 28-02-2019 Accepted on: 04-03-2019 Source of support: Nil Conflict of interest: None declared. How to cite this article: D. Princess Beulah, T. Avvai. A comprehensive study on incidence and risk factors of deep vein thrombosis in asymptomatic patient after prolonged surgery. IAIM, 2019; 6(3): 237-242. Abstract Background: Deep vein thrombosis (DVT) is one of the most dreaded complications in postoperative patients as it is associated with considerable morbidity and mortality. The prevalence of Deep Vein Thrombosis (DVT) in various series involving Western population ranges from 15% to 40% among patients undergoing major general surgical procedures. The aim of the study: To identify risk factors of deep vein thrombosis in asymptotic patients after prolonged surgery Age, Gender, Diabetes, Hypertension, COPD, Hyperlipidemia, Renal disorder, liver disorder, duration of surgery, blood transfusion, nature of surgery elective or emergency, type of surgery. -
Effects of Immediate Versus Delayed Antihypertensive Therapy on Outcome in the Systolic Hypertension in Europe Trial Jan A
Original article 847 Effects of immediate versus delayed antihypertensive therapy on outcome in the Systolic Hypertension in Europe Trial Jan A. Staessena, Lutgarde Thijsa, Robert Fagarda, Hilde Celisa, Willem H. Birkenha¨gerb, Christopher J. Bulpittc, Peter W. de Leeuwd, Astrid E. Fletchere, Franc¸oise Forettef, Gastone Leonettig, Patricia McCormackh, Choudomir Nachevi, Eoin O’Brienh, Jose´ L. Rodicioj, Joseph Rosenfeldk, Cinzia Sartil, Jaakko Tuomilehtol, John Websterm, Yair Yodfatn and Alberto Zanchettig, for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators Background To assess the impact of immediate versus systolic hypertension. Immediate compared with delayed delayed antihypertensive treatment on the outcome of treatment prevented 17 strokes or 25 major cardiovascular older patients with isolated systolic hypertension, we events per 1000 patients followed up for 6 years. These extended the double-blind placebo-controlled Systolic findings underscore the necessity of early treatment of Hypertension in Europe (Syst-Eur) trial by an open-label isolated systolic hypertension. J Hypertens 22:847–857 & follow-up study lasting 4 years. 2004 Lippincott Williams & Wilkins. Methods The Syst-Eur trial included 4695 randomized Journal of Hypertension 2004, 22:847–857 patients with minimum age of 60 years and an untreated Keywords: calcium-channel blocker, clinical trial, isolated systolic blood pressure of 160–219 mmHg systolic and below hypertension, outcome, myocardial infarction, stroke 95 mmHg diastolic. The double-blind -
Hypertension and Coronary Heart Disease
Journal of Human Hypertension (2002) 16 (Suppl 1), S61–S63 2002 Nature Publishing Group All rights reserved 0950-9240/02 $25.00 www.nature.com/jhh Hypertension and coronary heart disease E Escobar University of Chile, Santiago, Chile The association of hypertension and coronary heart atherosclerosis, damage of arterial territories other than disease is a frequent one. There are several patho- the coronary one, and of the extension and severity of physiologic mechanisms which link both diseases. coronary artery involvement. It is important to empha- Hypertension induces endothelial dysfunction, exacer- sise that complications and mortality of patients suffer- bates the atherosclerotic process and it contributes to ing a myocardial infarction are greater in hypertensive make the atherosclerotic plaque more unstable. Left patients. Treatment should be aimed to achieve optimal ventricular hypertrophy, which is the usual complication values of blood pressure, and all the strategies to treat of hypertension, promotes a decrease of ‘coronary coronary heart disease should be considered on an indi- reserve’ and increases myocardial oxygen demand, vidual basis. both mechanisms contributing to myocardial ischaemia. Journal of Human Hypertension (2002) 16 (Suppl 1), S61– From a clinical point of view hypertensive patients S63. DOI: 10.1038/sj/jhh/1001345 should have a complete evaluation of risk factors for Keywords: hypertension; hypertrophy; coronary heart disease There is a strong and frequent association between arterial hypertension.8 Hypertension is frequently arterial hypertension and coronary heart disease associated to metabolic disorders, such as insulin (CHD). In the PROCAM study, in men between 40 resistance with hyperinsulinaemia and dyslipidae- and 66 years of age, the prevalence of hypertension mia, which are additional risk factors of atheroscler- in patients who had a myocardial infarction was osis.9 14/1000 men in a follow-up of 4 years. -
Hypertensive Emergency
Presentation of hypertensive emergency Definitions surrounding hypertensive emergency Hypertension: elevated blood pressure (BP), usually defined as BP >140/90; pathological both in isolation and in association with other cardiovascular risk factors Severe hypertension: systolic BP (SBP) >200 mmHg and/or diastolic BP (DBP) >120 mmHg Hypertensive urgency: severe hypertension with no evidence of acute end organ damage Hypertensive emergency: severe hypertension with evidence of acute end organ damage Malignant/accelerated hypertension: a hypertensive emergency involving retinal vascular damage Causes of hypertensive emergency Usually inadequate treatment and/or poor compliance in known hypertension, the causes of which include: Essential hypertension o Age o Family history o Salt o Alcohol o Caffeine o Smoking o Obesity Secondary hypertension o Renal . Renal artery stenosis . Glomerulonephritis . Chonic pyelonephritis . Polycystic kidney disease o Endocrine . Cushing’s syndrome . Conn’s syndrome . Acromegaly . Hyperthyroidism . Phaeochromocytoma o Arterial . Coarctation of the aorta o Drugs . Alcohol . Cocaine . Amphetamines o Pregnancy . Pre-eclamplsia Pathophysiology of hypertensive emergency Abrupt rise in systemic vascular resistance Failure of normal autoregulatory mechanisms Fibrinoid necrosis of arterioles Damage to red blood cells from fibrin deposits causing microangiopathic haemolytic anaemia Microscopic haemorrhage Macroscopic haemorrhage Clinical features of hypertensive emergency Hypertensive encephalopathy o -
Hypertension and the Prothrombotic State
Journal of Human Hypertension (2000) 14, 687–690 2000 Macmillan Publishers Ltd All rights reserved 0950-9240/00 $15.00 www.nature.com/jhh REVIEW ARTICLE Hypertension and the prothrombotic state GYH Lip Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK The basic underlying pathophysiological processes related to conventional risk factors, target organ dam- underlying the major complications of hypertension age, complications and long-term prognosis, as well as (that is, heart attacks and strokes) are thrombogenesis different antihypertensive treatments. Further work is and atherogenesis. Indeed, despite the blood vessels needed to examine the mechanisms leading to this being exposed to high pressures in hypertension, the phenomenon, the potential prognostic and treatment complications of hypertension are paradoxically throm- implications, and the possible value of measuring these botic in nature rather than haemorrhagic. The evidence parameters in routine clinical practice. suggests that hypertension appears to confer a Journal of Human Hypertension (2000) 14, 687–690 prothrombotic or hypercoagulable state, which can be Keywords: hypercoagulable; prothrombotic; coagulation; haemorheology; prognosis Introduction Indeed, patients with hypertension are well-recog- nised to demonstrate abnormalities of each of these Hypertension is well-recognised to be an important 1 components of Virchow’s triad, leading to a contributor to heart attacks and stroke. Further- prothrombotic or hypercoagulable state.4 Further- more, effective antihypertensive therapy reduces more, the processes of thrombogenesis and athero- strokes by 30–40%, and coronary artery disease by 2 genesis are intimately related, and many of the basic approximately 25%. Nevertheless the basic under- concepts thrombogenesis can be applied to athero- lying pathophysiological processes underlying both genesis.