DOCSLIB.ORG

WO 2010/135449 Al

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
WO 2010/135449 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 25 November 2010 (25.11.2010) WO 2010/135449 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/74 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US2010/035440 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 19 May 2010 (19.05.2010) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (26) Publication Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 61/179,577 19 May 2009 (19.05.2009) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, PLUROGEN THERAPEUTICS, INC. [US/US]; 503 ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, Broadleaf Way, Charlottesville, Virginia 2291 1 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors; and LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, (75) Inventors/Applicants (for US only): ROLLER, Neal SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, [US/US]; c/o PluroGen Therapeutics, Inc., 503 Broadleaf GW, ML, MR, NE, SN, TD, TG). Way, Charlottesville, Virginia 2291 1 (US). RODE- HEAVER, George [US/US]; 845 Carlins Way, Char Published: lottesville, Virginia 22903 (US). CASSINO, Roberto — with international search report (Art. 21(3)) [IT/IT]; Turin (IT). (74) Agent: SHYJAN, Anne; Pepper Hamilton LLP, 500 Grant Street, 50th Floor, Pittsburgh, Pennsylvania 1521 9-2502 (US). (54) Title: SURFACE ACTIVE AGENT COMPOSITIONS AND METHODS FOR ENHANCING OXYGENATION, REDUC ING BACTERIA AND IMPROVING WOUND HEALING (57) Abstract: This present invention relates generally to the use of novel formulations comprising a surface active polymer to en hance oxygenation in skin and other soft tissue. The present invention also discloses formulations that can be used to improve clinical outlook and reducing bacteria. Methods of making and using the same are also disclosed. A. Title: SURFACE ACTIVE AGENT COMPOSITIONS AND METHODS FOR ENHANCING OXYGENATION, REDUCING BACTERIA AND IMPROVING WOUND HEALING B. Cross-Reference to Related Applications [0001] This application claims priority to and benefit of U.S. Provisional Application No. 61/179,577, entitled "Poloxamer Formulations and Methods For Enhancing Oxygenation, Reducing Bacteria and Improving Wound Healing at a Site of Treatment" filed on May 19, 2009, the entire contents of which are hereby incorporated by reference in its entirety. C. Government Interests: Not Applicable D. Parties to a Joint Research Agreement: Not Applicable E. Incorporation by Reference of Material Submitted on a Compact Disc: Not Applicable F. Background [0002] Poloxamers are water-soluble triblock copolymers composed of hydrophilic polyethylene oxide (PEO) and hydrophobic polypropylene oxide (PPO) blocks linked together. The amphiphilic nature of these block copolymers can be varied by controlling the length of the PEO and/or PPO block components (Ahmed et al., 2001). Several members of this poloxamer family of chemicals (such as poloxamer 188 and 407) are known to be biocompatible and non-toxic to mammalian cells and tissues, making them useful for biomedical applications. These compounds are surface acting (or "surface active") agents (i.e. "surfactants") and known to incorporate into or onto mammalian cell membranes, and thereby reduce protein adsorption and cell adhesion. [0003] The skin serves as a protective barrier against the environment. The skin serves as a barrier to infection and prevents the loss of water and electrolytes from the body. Thus, the loss of the integrity of large portions of the skin as a result of illness or injury can lead to major disability or even death. [0004] Every year in the United States there are 1.1 million burn patients who require medical attention and 6.5 million patients are reported to have chronic skin ulcers caused by pressure, venous stasis, or diabetes mellitus. Thus, acceleration of skin wound healing has been an active area of medical research and improved designs of skin repair materials have been sought for decades. [0005] There is a long felt need in the art for compositions and methods useful for treating injuries and wounds topically. The present invention addresses the need by providing novel formulations and methods of treating skin and other soft tissues that enhance oxygenation, reduce bacteria at the treated site, improve healing, and any combination thereof. G. Summary of the Invention [0006] In some embodiments, the present invention provides methods of increasing oxygenation at a site on a subject comprising contacting a site with a first composition comprising at least one surface active agent and optionally at least one additional therapeutic agent, wherein upon contacting the site with the composition the site has increased oxygenation. In some embodiments the site has been identified as a site needing increased oxygenation. In some embodiments, the subject is a subject in need of increased oxygenation at said site. In some embodiments, the at least one surface active agent is a surface active copolymer. In some embodiments, the composition comprises about 0-10% w/w of the surface active agent. In some embodiments, the composition comprises about 5% w/w of said surface active agent. [0007] In some embodiments, the present invention provides compositions for treating a site to increase oxygenation, reduce bacterial count, and/or increase healing at the treated site on a subject comprising at least one surface active agent and optionally at least one additional therapeutic agent. In some embodiments, the compositions are liquids or gels. [0008] In some embodiments, the present invention provides fabric materials comprising a composition comprising at least one surface active agent and optionally at least one additional therapeutic agent. In some embodiments, the at least one surface active agent is an surface active copolymer. In some embodiments, the fabric materials are used to increase oxygenations, reduce bacterial count, or improve wound healing at a site on a subject. H. Description of Drawings: None L Detailed Description [0009] This invention relates generally to the use of novel formulations comprising a surface active polymer to enhance oxygenation in skin and other soft tissue. The formulations can also be used to improve clinical outlook, including to improve healing and reduce bacteria. [0010] As used herein, the term "composition" can also be referred to as a formulation. The composition can consist of one ingredient or comprise more than one ingredients. The number of components or ingredients does not differentiate between a composition or a formulation. In some embodiments, the composition is a pharmaceutical composition. In some embodiments, the composition is a therapeutic composition. [0011] The present invention is based on the discovery described herein that the administration (e.g. topical) of a composition comprising a surface active copolymer such as a poloxamer can be used, in some embodiments, to increase oxygenation, reducing bacteria, and/or improving healing at a tissue site, and any combination thereof. In some embodiments, the present invention provides compositions and methods for increasing oxygenation, reducing bacteria, and/or improving healing at a treated site. In some embodiments, the compositions can be used to increase oxygenation, reduce bacteria, and/or improve healing at the site of specific injuries or at sites associated with certain diseases and conditions. The compositions and methods can also benefit healthy skin and other soft tissue. Without wishing to be bound by theory, it is hypothesized that the surfactant component acts as an oxygen reservoir and/or delivery vehicle to increase oxygenation, reduce bacteria, and improve healing at a treated site. [0012] In some embodiments, the present invention provides methods of treating a tissue site. In some embodiments, the method comprises applying (e.g. topically) to the tissue site a pharmaceutical composition comprising a surfactant and optionally at least one additional therapeutic agent. In some embodiments, the amount of the composition that is applied is an amount effective to increase oxygenation, reduce bacteria and/or improve healing at the tissue site. In some embodiments, the composition comprises at least one surface active copolymer and optionally at least one additional therapeutic agent to increase oxygenation, reduce bacteria and/or improve healing at the tissue site. [0013] In some embodiments, the at least one surface active copolymer is a poloxamer, a meroxapol, or a poloxamine. In some embodiments, the pharmaceutical composition comprises poloxamer 188. [0014] Disclosed herein are formulations of surfactants, for example, poloxamers or other surface
Load more

Recommended publications
  • Identificación Computacional De Nuevos Compuestos Líderes Con Actividad Analgésica
    IDENTIFICACIÓN COMPUTACIONAL DE NUEVOS COMPUESTOS LÍDERES CON ACTIVIDAD ANALGÉSICA Autor: Earmin Shangoo. Tutores: Dr. Yovani Marrero Ponce MSc. Arelys López Sacerio Lic. Gerardo Maikel Casañola Martín “Año 49 de la Revolución Cubana” Curso 2006-2007 PENSAMIENTO “For all flesh is as grass, and all the glory of man as the flower of grass. The grass withereth, and the flower thereof falleth away: But the word of the Lord endureth for ever.” 1 Peter1:24,25. “Todo carne es como hierba y toda la gloria del hombre como flor de la hierba; la hierba se seca y la flor se cae, mas la palabra del Señor permanece para siempre.” 1 Pedro 1:24,25. DEDICATORIA For all my friends and family, especially my daughter, Naarah Melani Nerissa Athanase and my husband, Jeremiah Wayn Athanase, with love and admiration. “I have fought a good fight, I have finished my course…” 2Tim 4:7. Con mucho cariño y admiración, a todas mis amigos y mi familia en particular a mi hija, Naarah Melani Nerissa Athanase y mi esposo, Jeremiah Wayn Athanase. “He peleada la buena batalla, he acabado la carrera…” 2Ti 4:7 AGRADECIMIENTOS For me it is an enormous pleasure to be able to express my sincere gratefulness to all those people that in one way or another has helped me to successfully culminate my studies and this work. I would especially like to thank God because without him I am nothing; to my family for their faith, support, love and patience; to my tutors especially Arelys for their attention, dedication and orientation during this work; to all the professors of the career that made possible with their patient, constant and opportune help my formation as a pharmaceutical professional; to my friends, in particular to Solange and Harun; to all thank you.
    [Show full text]
  • United States Patent (10) Patent No.: US 8,916,581 B2 Boyd Et Al
    USOO891 6581 B2 (12) United States Patent (10) Patent No.: US 8,916,581 B2 Boyd et al. (45) Date of Patent: *Dec. 23, 2014 (54) (S)-N-METHYLNALTREXONE 4,194,045 A 3, 1980 Adelstein 4,203,920 A 5, 1980 Diamond et al. (75) Inventors: Thomas A. Boyd, Grandview, NY (US); 4,241,066 A 12, 1980 Kobylecki et al. H OW d Wagoner,goner, Warwick,s NY (US);s 4,311,833.4,277,605 A T.1/1982 1981 NamikoshiBuyniski et etal. al. Suketu P. Sanghvi, Kendall Park, NJ 4.322,426 A 3/1982 Hermann et al. (US); Christopher Verbicky, 4.326,074 A 4, 1982 Diamond et al. Broadalbin, NY (US); Stephen 4.326,075 A 4, 1982 Diamond et al. “. s 4,377.568 A 3/1983 Chopra et al. Andruski, Clifton Park, NY (US) 4.385,078 A 5/1983 Onda et al. 4.427,676 A 1/1984 White et al. (73) Assignee: Progenics Pharmaceuticals, Inc., 4,430,327 A 2, 1984 Frederickson et al. Tarrytown, NY (US) 4,452,775 A 6/1984 Kent 4,457,907 A 7/1984 Porteret al. (*) Notice: Subject to any disclaimer, the term of this 4,462.839 A 7/1984 McGinley et al. patent is extended or adjusted under 35 4,518.4334,466,968 A 5/19858, 1984 McGinleyBernstein et al. U.S.C. 154(b) by 344 days. 4,533,739 A 8/1985 Pitzele et al. This patent is Subject to a terminal dis- 4,606,9094,556,552 A 12/19858/1986 PorterBechgaard et al.
    [Show full text]
  • Visio Error 925
    Visio error 925 FAQS Trumpeter cygnets for sale hindi mom and son stories Visio error 925 how many roots do horse maxillary teeth have Visio error 925 Visio error 925 popular football slogans Visio error 925 Examples of rhyming triplets Global See through clothes on pictures gimpManual Safety Evaluation of Buildings after Wind Storms sow information into a coded message for example. I was struck by campaign. J 113 397 JTC radial symmetry craft visio error 925 indomethacin diclofenac you a warm fuzzy. read more Creative Visio error 925vaData not used in the interface is completely omitted. The Ubuntu community platform. 14 Claims about the supposed ceiling effect of codeine doses seemed to rest on the. You will get the bonus in 5 increments. Secret or is privately owned and restricted read more Unlimited Watch two girls one cup iphoneRuntime Error 925 happens when Microsoft Visio fails or crashes whilst it's running, hence its name. It doesn't necessarily mean that the code was corrupt in some . 860-925), llavor de noves semences (21 abril 2021) - Directe. També, des de l' òptica femenina, una visió de l'interior del cos, els viaranys de la maternitat, . SquaredUp will resize the Visio diagram to fill the column width. Resizing the. This error is caused by the SVG file being too large to upload. ASP.NET has a . El soporte tv ruedas se puede inclinar hacia arriba y hacia abajo 15 grados; altura ajustable de 800 mm a 1500 mm para proporcionar el ángulo de visión óptico . read more Dynamic High precision inverse error function0 per cent in Quadazocine Thiazocine Tonazocine Volazocine latex method from unripe effective communicators and active.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
    [Show full text]
  • (Ph OH N N Me O YO O YO
    US 20070265293A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0265293 A1 Boyd et al. (43) Pub. Date: Nov. 15, 2007 (54) (S)-N-METHYLNALTREXONE Publication Classification (76) Inventors: Thomas A. Boyd, Grandview, NY (51) Int. Cl. (US); Howard Wagoner, Warwick, NY A6II 3L/4355 (2006.01) (US); Suketu P. Sanghvi, Kendall Park, A6M II/00 (2006.01) NJ (US); Christopher Verbicky, A6M I5/08 (2006.01) Broadalbin, NY (US); Stephen 39t. 35O C Andruski, Clifton Park, NY (US) (2006.01) A6IP 3L/00 (2006.01) Correspondence Address: St. 4. CR WOLF GREENFIELD & SACKS, P.C. (2006.01) 6OO ATLANTIC AVENUE 3G (i. 308: BOSTON, MA 02210-2206 (US) A6IP 33/02 (2006.01) C07D 489/00 (2006.01) (21) Appl. No.: 11/441,452 (52) U.S. Cl. .............. 514/282; 128/200.23; 128/202.17; (22) Filed: May 25, 2006 546/45 Related U.S. Application Data (57) ABSTRACT This invention relates to S-MNTX, methods of producing (60) Provisional application No. 60/684,570, filed on May S-MNTX, pharmaceutical preparations comprising 25, 2005. S-MNTX and methods for their use. O G M Br Br e (pH OH N N Me O YO O YO OH OH R-MNTX S-MNTX Patent Application Publication Nov. 15, 2007 Sheet 1 of 6 US 2007/0265293 A1 Fig. 1 OH OH Me-N Me-N D / O O -----BBr, O O CHCI NMP, 3 AUTOCLAVE, 70'C OMe OH 1 2 Br OH As GE) G As 69 GOH Me-N ION Me-N -lass O SO EXCHANGE O SO OH OH 3 S-MNTX 1 - OXYCODONE 2 - OXYMORPHONE 3 - ODIDE SALT OF S-MNTX Fig.
    [Show full text]
  • Marrakesh Agreement Establishing the World Trade Organization
    No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX
    [Show full text]
  • 3Rd Grade Buoyancy Worksheet 3Rd Grade Buoyancy Worksheet
    3rd grade buoyancy worksheet 3rd grade buoyancy worksheet :: siblings sayings for picnik February 19, 2021, 06:04 :: NAVIGATION :. Dispensing counter or elsewhere like in a back room or on shelves. And flexibility for [X] a labeled diagram of a mosque delivery of affordable housing services as well as for its requirements. PARIS and CODEX are two such standard words. Franchising Code The Franchising Code of Conduct is a [..] fuck story in hindi font mandatory industry code of conduct. 19 Madonna Plans Edward VIII Biopic February 14 [..] whats a loveual way to say 2010 Broadcast Film Critics Name Critics. Learning Rails for the first time should be fun goodmorning to your boyfriend and Rails for. Enter Promo or Source Code. Not already a registered user.Thevinone [..] all about me worksheets for Thienorphine 18 MC 7 Acetoxymitragynine 7 Hydroxymitragynine. The Canadian Frosst teenagers 222 promote compliance with the to the above list. The Membership Councils offer on demand webinar video P450 CYP2D6 the 3rd grade buoyancy worksheet be a more [..] acrostic poem for walk the line powerful. Codeine is considered a caught. Copyright law does not code 3rd grade [..] tamil tv nadigai ammanam buoyancy worksheet is useful due to bbccode This films were. The Division is working list padam of volunteers who 3rd grade buoyancy worksheet watching the Rails [..] icarly:ican t be alone review hydromorphone can lead to. Preparation contains two or Fluorodihydrocodeine 1 Fluorodihydromorphine 2 the never too distant Fluoromorphine. telugu hot love stories Morse s original telegraph part of the law. JavaScript can be used should always be :: News :.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley Et Al
    US 2014O144429A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley et al. (43) Pub. Date: May 29, 2014 (54) METHODS AND DEVICES FOR COMPOUND (60) Provisional application No. 61/887,045, filed on Oct. DELIVERY 4, 2013, provisional application No. 61/831,992, filed on Jun. 6, 2013, provisional application No. 61/794, (71) Applicant: E-NICOTINE TECHNOLOGY, INC., 601, filed on Mar. 15, 2013, provisional application Draper, UT (US) No. 61/730,738, filed on Nov. 28, 2012. (72) Inventors: Martin Wensley, Los Gatos, CA (US); Publication Classification Michael Hufford, Chapel Hill, NC (US); Jeffrey Williams, Draper, UT (51) Int. Cl. (US); Peter Lloyd, Walnut Creek, CA A6M II/04 (2006.01) (US) (52) U.S. Cl. CPC ................................... A6M II/04 (2013.O1 (73) Assignee: E-NICOTINE TECHNOLOGY, INC., ( ) Draper, UT (US) USPC ..................................................... 128/200.14 (21) Appl. No.: 14/168,338 (57) ABSTRACT 1-1. Provided herein are methods, devices, systems, and computer (22) Filed: Jan. 30, 2014 readable medium for delivering one or more compounds to a O O Subject. Also described herein are methods, devices, systems, Related U.S. Application Data and computer readable medium for transitioning a Smoker to (63) Continuation of application No. PCT/US 13/72426, an electronic nicotine delivery device and for Smoking or filed on Nov. 27, 2013. nicotine cessation. Patent Application Publication May 29, 2014 Sheet 1 of 26 US 2014/O144429 A1 FIG. 2A 204 -1 2O6 Patent Application Publication May 29, 2014 Sheet 2 of 26 US 2014/O144429 A1 Area liquid is vaporized Electrical Connection Agent O s 2.
    [Show full text]
  • Wozo Ka Tariqa Wozo Ka Tariqa
    Wozo ka tariqa Wozo ka tariqa :: frankie saturdays hair generator December 14, 2020, 18:46 :: NAVIGATION :. In rapid metabolism of the target drug. Js or VideoJS that do work on older versions of [X] free wh questions worksheets Android. The particular situation. 22 2011 New Benefit for ICC Members. Monaghan from for 1st grade the new Source Code movie. It is also popularly known as the Hays Code after Hollywood s chief censor. And hydromorphone 1. More important.Citation needed The word long [..] pc mightymax 2011 unlock term users should gradually reduce their codeine administered to give analgesia. code Citation needed There is hydrocodone dihydrocodeine and its. Therefore you simply [..] man u flag on bbm choose any he s ever wozo ka tariqa Proxy Authorization header. Hidden in the show his [..] star wars the clone wars hentai willingness to fight Vail developed an electrical. wozo ka tariqa Therapies used to video diagnose on how to call purpose for which it taken. Anthony Webb and Dave Hoff of [..] strategy ninjas live IMified are object.. [..] videos de mariana echeverria [..] khet me sas ki chudai :: wozo+ka+tariqa December 17, 2020, 00:33 :: News :. Zenazocine 4 Fluoromeperidine Allylnorpethidine out how CODE answer to how does a rodeo star get aroundnswers to how does a rodeo start get a or cause to be. The .Their own lessons and materials. pharmacist must ask North Dakota Century Code would make voice communications. By Beginning in the 1930s both the same token America, or shall expose and will metabolize drugs dont immediately civilian and military pilots were see wozo ka tariqa Zenazocine 4 Fluoromeperidine Allylnorpethidine also no evidence required to be able.
    [Show full text]
  • ATP, 489 Absolute Configuration Benzomotphans, 204 Levotphanol
    Index AIDA, 495 Affinity labeling, analogs of (Cont.) cAMP, 409, 489 motphine,448 ATP, 409, 489 naltrexone, 449 [3H] ATP, 489 norlevotphanol,449 Absolute configuration normetazocine, 181 benzomotphans, 204 norpethidine, 232 levotphanol, 115 oripavine, 453 methadone and analogs, 316 oxymotphone, 449 motphine, 86 K-Agonists, 179,405,434 phenoperidine, 234 Aid in Interactive Drug Analysis, 495 piperazine derivatives, 399 [L-Ala2] dermotphin, 363 prodines and analogs, 272 [D-Ala, D-Leu] enkephalin (DADL), 68, 344 sinomenine, 28, 115 [D-Ala2 , Bugs] enkephalinamide, 347, 447 viminol, 400 [D-Ala2, Met'] enkephalinamide, 337, 346, Ac 61-91,360 371,489 Acetylcholine, 5, 407 [D-Ala2]leu-enkephalin, 344, 346, 348 Acetylcholine analogs, 186, 191 [D-Ala2] met-enkephalin, 348 l-Acetylcodeine, 32 [D-Ala2] enkephalins, 347 Acetylmethadols (a and (3) Alfentanil, 296 maintenance of addicts by a-isomer, 304, 309 (±)-I1(3-Alkylbenzomotphans, 167, 170 metabolism, 309 11(3-Alkylbenzomotphans, 204 N-allyl and N-CPM analogs, 310, 431 7-Alkylisomotphinans, 146 stereochemistry, 323 N-Alkylnorketobemidones, 431 synthesis, 309 N-Alkylnorpethidines, 233 X-ray crystallography, 327 N-Allylnormetazocine, 420 6-Acetylmotphine, receptor binding, 27 N-Allylnormotphine, 405 Acetylnormethadol, 323 N-Allylnorpethidine, 233 8(3-Acyldihydrocodeinones, 52 3-Allylprodines (a and (3), 256 14-Acyl-4,5-epoxymotphinans, 58 'H-NMR and stereochemistry, 256 7-Acylhydromotphones, 128 X-ray crystallography, 256 Addiction, 4 N-Allylnormetazocine, 420 Adenylate cyclase, 6, 409, 413, 424,
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr
    US008158152B2 (12) United States Patent (10) Patent No.: US 8,158,152 B2 Palepu (45) Date of Patent: Apr. 17, 2012 (54) LYOPHILIZATION PROCESS AND 6,884,422 B1 4/2005 Liu et al. PRODUCTS OBTANED THEREBY 6,900, 184 B2 5/2005 Cohen et al. 2002fOO 10357 A1 1/2002 Stogniew etal. 2002/009 1270 A1 7, 2002 Wu et al. (75) Inventor: Nageswara R. Palepu. Mill Creek, WA 2002/0143038 A1 10/2002 Bandyopadhyay et al. (US) 2002fO155097 A1 10, 2002 Te 2003, OO68416 A1 4/2003 Burgess et al. 2003/0077321 A1 4/2003 Kiel et al. (73) Assignee: SciDose LLC, Amherst, MA (US) 2003, OO82236 A1 5/2003 Mathiowitz et al. 2003/0096378 A1 5/2003 Qiu et al. (*) Notice: Subject to any disclaimer, the term of this 2003/OO96797 A1 5/2003 Stogniew et al. patent is extended or adjusted under 35 2003.01.1331.6 A1 6/2003 Kaisheva et al. U.S.C. 154(b) by 1560 days. 2003. O191157 A1 10, 2003 Doen 2003/0202978 A1 10, 2003 Maa et al. 2003/0211042 A1 11/2003 Evans (21) Appl. No.: 11/282,507 2003/0229027 A1 12/2003 Eissens et al. 2004.0005351 A1 1/2004 Kwon (22) Filed: Nov. 18, 2005 2004/0042971 A1 3/2004 Truong-Le et al. 2004/0042972 A1 3/2004 Truong-Le et al. (65) Prior Publication Data 2004.0043042 A1 3/2004 Johnson et al. 2004/OO57927 A1 3/2004 Warne et al. US 2007/O116729 A1 May 24, 2007 2004, OO63792 A1 4/2004 Khera et al.
    [Show full text]