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Uniform Faint Reticulate Pigment Network - a Dermoscopic Hallmark of Nevus Depigmentosus
Our Dermatology Online Letter to the Editor UUniformniform ffaintaint rreticulateeticulate ppigmentigment nnetworketwork - A ddermoscopicermoscopic hhallmarkallmark ooff nnevusevus ddepigmentosusepigmentosus Surit Malakar1, Samipa Samir Mukherjee2,3, Subrata Malakar3 11st Year Post graduate, Department of Dermatology, SUM Hospital Bhubaneshwar, India, 2Department of Dermatology, Cloud nine Hospital, Bangalore, India, 3Department of Dermatology, Rita Skin Foundation, Kolkata, India Corresponding author: Dr. Samipa Samir Mukherjee, E-mail: [email protected] Sir, ND is a form of cutaneous mosaicism with functionally defective melanocytes and abnormal melanosomes. Nevus depigmentosus (ND) is a localized Histopathologic examination shows normal to hypopigmentation which most of the time is congenital decreased number of melanocytes with S-100 stain and and not uncommonly a diagnostic challenge. ND lesions less reactivity with 3,4-dihydroxyphenylalanine reaction are sometimes difficult to differentiate from other and no melanin incontinence [2]. Electron microscopic hypopigmented lesions like vitiligo, ash leaf macules and findings show stubby dendrites of melanocytes nevus anemicus. Among these naevus depigmentosus containing autophagosomes with aggregates of poses maximum difficulty in differentiating from ash melanosomes. leaf macules because of clinical as well as histological similarities [1]. Although the evolution of newer diagnostic For ease of understanding the pigmentary network techniques like dermoscopy has obviated the -
Pityriasis Alba Revisited: Perspectives on an Enigmatic Disorder of Childhood
Pediatric ddermatologyermatology Series Editor: Camila K. Janniger, MD Pityriasis Alba Revisited: Perspectives on an Enigmatic Disorder of Childhood Yuri T. Jadotte, MD; Camila K. Janniger, MD Pityriasis alba (PA) is a localized hypopigmented 80 years ago.2 Mainly seen in the pediatric popula- disorder of childhood with many existing clinical tion, it primarily affects the head and neck region, variants. It is more often detected in individuals with the face being the most commonly involved with a darker complexion but may occur in indi- site.1-3 Pityriasis alba is present in individuals with viduals of all skin types. Atopy, xerosis, and min- all skin types, though it is more noticeable in those with eral deficiencies are potential risk factors. Sun a darker complexion.1,3 This condition also is known exposure exacerbates the contrast between nor- as furfuraceous impetigo, erythema streptogenes, mal and lesional skin, making lesions more visible and pityriasis streptogenes.1 The term pityriasis alba and patients more likely to seek medical atten- remains accurate and appropriate given the etiologic tion. Poor cutaneous hydration appears to be a elusiveness of the disorder. common theme for most riskCUTIS factors and may help elucidate the pathogenesis of this disorder. The Epidemiology end result of this mechanism is inappropriate mel- Pityriasis alba primarily affects preadolescent children anosis manifesting as hypopigmentation. It must aged 3 to 16 years,4 with onset typically occurring be differentiated from other disorders of hypopig- between 6 and 12 years of age.5 Most patients are mentation, such as pityriasis versicolor alba, vitiligo, younger than 15 years,3 with up to 90% aged 6 to nevus depigmentosus, and nevus anemicus. -
Phacomatosis Spilorosea Versus Phacomatosis Melanorosea
Acta Dermatovenerologica 2021;30:27-30 Acta Dermatovenerol APA Alpina, Pannonica et Adriatica doi: 10.15570/actaapa.2021.6 Phacomatosis spilorosea versus phacomatosis melanorosea: a critical reappraisal of the worldwide literature with updated classification of phacomatosis pigmentovascularis Daniele Torchia1 ✉ 1Department of Dermatology, James Paget University Hospital, Gorleston-on-Sea, United Kingdom. Abstract Introduction: Phacomatosis pigmentovascularis is a term encompassing a group of disorders characterized by the coexistence of a segmental pigmented nevus of melanocytic origin and segmental capillary nevus. Over the past decades, confusion over the names and definitions of phacomatosis spilorosea, phacomatosis melanorosea, and their defining nevi, as well as of unclassifi- able phacomatosis pigmentovascularis cases, has led to several misplaced diagnoses in published cases. Methods: A systematic and critical review of the worldwide literature on phacomatosis spilorosea and phacomatosis melanorosea was carried out. Results: This study yielded 18 definite instances of phacomatosis spilorosea and 14 of phacomatosis melanorosea, with one and six previously unrecognized cases, respectively. Conclusions: Phacomatosis spilorosea predominantly involves the musculoskeletal system and can be complicated by neuro- logical manifestations. Phacomatosis melanorosea is sometimes associated with ancillary cutaneous lesions, displays a relevant association with vascular malformations of the brain, and in general appears to be a less severe syndrome. -
2018 Abstract Book
CONTENTS Table of Contents INFORMATION Continuing Medical Education .................................................................................................5 Guidelines for Speakers ..........................................................................................................6 Guidelines for Poster Presentations .........................................................................................8 SPEAKER ABSTRACTS Abstracts ...............................................................................................................................9 POSTER ABSTRACTS Basic Research (Location – Room 101) ...............................................................................63 Clinical (Location – Room 8) ..............................................................................................141 2018 Joint Global Neurofibromatosis Conference · Paris, France · November 2-6, 2018 | 3 4 | 2018 Joint Global Neurofibromatosis Conference · Paris, France · November 2-6, 2018 EACCME European Accreditation Council for Continuing Medical Education 2018 Joint Global Neurofibromatosis Conference Paris, France, 02/11/2018–06/11/2018 has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) for a maximum of 27 European CME credits (ECMEC®s). Each medical specialist should claim only those credits that he/she actually spent in the educational activity. The EACCME® is an institution of the European Union of Medical Specialists (UEMS), www.uems.net. Through an agreement between -
The Frequency of Superficial Mycoses According to Agents Isolated During a Ten-Year Period (1999-2008) in Zagreb Area, Croatia
Acta Dermatovenerol Croat 2010;18(2):92-98 CLINICAL ARTICLE The Frequency of Superficial Mycoses According to Agents Isolated During a Ten-Year Period (1999-2008) in Zagreb Area, Croatia Paola Miklić, Mihael Skerlev, Dragomir Budimčić, Jasna Lipozenčić University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia Corresponding author: SUMMARY Fungal infections involving the skin, hair and nails represent Paola Miklić, MD one of the most common mucocutaneous infections. Significant changes in the epidemiology, etiology and clinical pattern of mycotic University Department of Dermatology infections have been observed during the last years. The aim of this and Venereology retrospective study was to determine the incidence and the etiologic Zagreb University Hospital Center factors of superficial fungal infections in Zagreb area, Croatia, over a and School of Medicine 10-year period (1999-2008). A total of 75828 samples obtained from 67 983 patients were analyzed. Dermatomycosis was verified by culture in Šalata 4 17410 (23%) samples obtained from 16086 patients. Female patients HR-10000 Zagreb were more commonly affected than male (59% vs. 41%). Dermatophytes Croatia were responsible for 63% of all superficial fungal infections, followed by yeasts (36%) and molds (1%). Trichophyton (T.) mentagrophytes [email protected] (both var. interdigitalis and var. granulosa) was the most frequent dermatophyte isolated in 58% of all samples, followed by Microsporum Received: November 10, 2009 (M). canis (29%) and T. rubrum (10%). The most common clinical forms of dermatomycosis were onychomycosis (41%), tinea corporis (17%) Accepted: April 20, 2010 and tinea pedis (12%). Candida spp. was mainly isolated from fingernail debris. -
Therapies for Common Cutaneous Fungal Infections
MedicineToday 2014; 15(6): 35-47 PEER REVIEWED FEATURE 2 CPD POINTS Therapies for common cutaneous fungal infections KENG-EE THAI MB BS(Hons), BMedSci(Hons), FACD Key points A practical approach to the diagnosis and treatment of common fungal • Fungal infection should infections of the skin and hair is provided. Topical antifungal therapies always be in the differential are effective and usually used as first-line therapy, with oral antifungals diagnosis of any scaly rash. being saved for recalcitrant infections. Treatment should be for several • Topical antifungal agents are typically adequate treatment weeks at least. for simple tinea. • Oral antifungal therapy may inea and yeast infections are among the dermatophytoses (tinea) and yeast infections be required for extensive most common diagnoses found in general and their differential diagnoses and treatments disease, fungal folliculitis and practice and dermatology. Although are then discussed (Table). tinea involving the face, hair- antifungal therapies are effective in these bearing areas, palms and T infections, an accurate diagnosis is required to ANTIFUNGAL THERAPIES soles. avoid misuse of these or other topical agents. Topical antifungal preparations are the most • Tinea should be suspected if Furthermore, subsequent active prevention is commonly prescribed agents for dermatomy- there is unilateral hand just as important as the initial treatment of the coses, with systemic agents being used for dermatitis and rash on both fungal infection. complex, widespread tinea or when topical agents feet – ‘one hand and two feet’ This article provides a practical approach fail for tinea or yeast infections. The pharmacol- involvement. to antifungal therapy for common fungal infec- ogy of the systemic agents is discussed first here. -
Tinea Incognito
TINEA INCOGNITO http://www.aocd.org Tinea incognito is a localized skin infection caused by fungus, just like tinea corporis (ringworm) and tinea capitis (scalp ringworm). It is a skin infectious process that looks very different from other fungal infections, both the shape and the degree of involvement. Topical corticosteroid use is the culprit for the difference. Fungal infection, most often caused by Trichophyton rubrum, presents initially as a flat, scaly rash that gradually becomes a circular lesion with a raised border and the border is scaly as it advances. While the lesion enlarges, the center becomes brown or less pigmented. These skin findings comprise of the ringworm we typically see on the body. Lesions can be large or small. At this stage of the disease, if a topical corticosteroid is applied to the lesion, the local inflammation from the fungal infection will be decreased, so to alter the clinical presentation of the typical infection. And this secondary appearance is called tinea incognito. The most common site for this clinical transformation is the face and the back of the hand. The hand is a popular site for a lot of skin diseases, which is why tinea incognito is hard to diagnose and be differentiated from the others. Altered clinical picture of tinea incognito could resemble eczema, psoriasis and other diseases. What makes the clarification important is the difference in treatment approach. Corticosteroid makes tinea worse but helps the other ones. The new appearance of tinea incognito is quite different from other fungal infections. Instead of a localized lesion, it becomes much more extensive and loses its original circular shape, which is one of the most important clinical clues to diagnose fungal infection. -
Dermoscopy of Inflammatory Dermatoses (Inflammoscopy): an Up-To-Date Overview
Dermatology Practical & Conceptual Dermoscopy of Inflammatory Dermatoses (Inflammoscopy): An Up-to-Date Overview Enzo Errichetti1 1 Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy Key words: dermoscopy, differential diagnosis, general dermatology, inflammoscopy Citation: Errichetti E. Dermoscopy of inflammatory dermatoses (inflammoscopy): an up-to-date overview. Dermatol Pract Concept. 2019;9(3):169-180. DOI: https://doi.org/10.5826/dpc.0903a01 Accepted: June 2, 2019; Published: July 31, 2019 Copyright: ©2019 Errichetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: None. Competing interests: The author has no conflicts of interest to disclose. Authorship: The author takes responsibility for this publication. Corresponding author: Enzo Errichetti, MD, MSc, Institute of Dermatology, Santa Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia, 15, 33100 Udine, Italy. Email: [email protected] ABSTRACT In addition to its use in pigmented and nonpigmented skin tumors, dermoscopy is gaining apprecia- tion in assisting the diagnosis of nonneoplastic diseases, especially inflammatory dermatoses (inflam- moscopy). In this field, dermoscopic examination should be considered as the second step of a “2-step procedure,” always preceded by the establishment of a differential diagnosis on the basis of clinical examination. In this paper, we sought to provide an up-to-date overview on the use of dermoscopy in common inflammatory dermatoses based on the available literature data. For practical purposes, the analyzed dermatoses are grouped according to the clinical presentation pattern, in line with the 2-step procedure principle: erythematous-desquamative and papulosquamous dermatoses, papulokeratotic dermatoses, erythematous facial dermatoses, sclero-atrophic dermatoses, and miscellaneous. -
Tacrolimus-Induced Tinea Incognito
Tacrolimus-Induced Tinea Incognito Narendra Siddaiah, MD; Capt Quenby Erickson, USAF, MC; Gea Miller, MD; Dirk M. Elston, MD Tacrolimus and pimecrolimus represent a new class of topical nonsteroidal medications cur- rently used in the treatment of a variety of inflam- matory skin lesions. We report the case of a patient in whom topical tacrolimus therapy resulted in widespread lesions of tinea incognito. This case shows that partial treatment of derma- tophytosis with griseofulvin may obscure the diagnosis. It also suggests that topical tacro- limus appears capable of inducing widespread dermatophytosis. The clinical appearance in this case was similar to tinea incognito induced by a topical corticosteroid. Cutis. 2004;73:237-238. he term tinea incognito is generally used to describe a dermatophytic infection whose T appearance is modified by the use of cortico- steroids.1 Steroids suppress local immunity, thus pro- moting fungal growth. Lesions often lack the degree of inflammation associated with tinea, and diagnosis is often delayed. Tacrolimus is 1 of 2 topical macrolide calcineurin inhibitors with potent immunomodula- Figure 1. Annular erythematous and scaly patches on tory activity approved in the treatment of atopic the face. dermatitis. We describe the case of a patient with wide- spread tinea incognito secondary to topical tacrolimus. One year before presentation, the child and his Case Report 4-year-old brother were treated with a 6-week course A 9-year-old black male child presented to the der- of griseofulvin 12.5 mg/kg per day for tinea capitis, matology clinic with large erythematous and scaly and his mother was treated with topical antifungal patches on his face, neck, and trunk (Figures 1 and agents for tinea corporis. -
Incidence and Biodiversity of Yeasts, Dermatophytes and Non
Journal de Mycologie Médicale (2017) 27, 166—179 Available online at ScienceDirect www.sciencedirect.com ORIGINAL ARTICLE/ARTICLE ORIGINAL Incidence and biodiversity of yeasts, dermatophytes and non-dermatophytes in superficial skin infections in Assiut, Egypt Incidence et biodiversite´ des levures, des dermatophytes, et non dermatophytes, agents de mycoses superficielles dans le gouvernorat d’Assiout — ´Egypte A.H. Moubasher, M.A. Abdel-Sater *, Z. Soliman Department of Botany and Microbiology, Faculty of Science, Assiut University Mycological Centre, Assiut University, Assiut, Egypt Received 1st October 2016; received in revised form 28 December 2016; accepted 11 January 2017 Available online 7 February 2017 KEYWORDS Summary Skin infections; Objective. — The aim was to identify the incidence of the causal agents from dermatophytes, Yeasts; non-dermatophytes and yeasts in Assiut Governorate employing, beside the morphological and Dermatophytic; physiological techniques, the genotypic ones. Non-dermatophytic; Patients. — Samples from infected nails, skin and hair were taken from 125 patients. PCR Materials and methods. — Patients who presented with onychomycosis, tinea capitis, tinea corporis, tinea cruris and tinea pedis during the period from February 2012 to October 2015 were clinically examined and diagnosed by dermatologists and were guided to Assiut University Mycological Centre for direct microscopic examination, culturing and identification. Results. — Onychomycosis was the most common infecting (64.8% of the cases) followed by tinea capitis (17.6%). Direct microscopic preparations showed only 45 positive cases, while 96 cases showed positive cultures. Infections were more frequent in females than males. Fifty-one fungal species and 1 variety were obtained. Yeasts were the main agents being cultured from 46.02% of total cases. -
Granulosis Rubra Nasi Response to Topical Tacrolimus
Hindawi Case Reports in Dermatological Medicine Volume 2017, Article ID 2519814, 3 pages https://doi.org/10.1155/2017/2519814 Case Report Granulosis Rubra Nasi Response to Topical Tacrolimus Farhana Tahseen Taj,1 Divya Vupperla,2 and Prarthana B. Desai1 1 Department of Dermatology, Venereology & Leprosy, Jawaharlal Nehru Medical College and KLE’s Dr. Prabhakar Kore Hospital and MedicalResearchCentre,Belgaum,Karnataka590010,India 2Department of Dermatology, Venereology & Leprosy, Government District Headquarters Hospital, Khammam, Andhra Pradesh 507 002, India Correspondence should be addressed to Farhana Tahseen Taj; [email protected] Received 1 September 2017; Accepted 8 November 2017; Published 29 November 2017 Academic Editor: Jacek Cezary Szepietowski Copyright © 2017 Farhana Tahseen Taj et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face, most commonly on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip. It is commonly seen in childhood but it can present in adults. Here we report a case of GRN in an adult patient with very unusual histopathological presentation. 1. Introduction itching or burning (Figure 1). Clinically, we made a diagnosis of Granulosis Rubra Nasi, Lymphangioma Circumscriptum, Granulosis Rubra Nasi (GRN) is also known as “Acne Nevus Comedonicus, and sebaceous gland hyperplasia. papulo-rosacea of the nose.”. In 1901, a German dermatol- A biopsy of the skin lesion was done. -
Phacomatosis Pigmentovascularis Revisited and Reclassified
REVIEW Phacomatosis Pigmentovascularis Revisited and Reclassified Rudolf Happle, MD Objective: To provide a new comprehensible and prac- morata (blue spots and cutis marmorata telangiectatica ticable classification by use of descriptive terms to dis- congenita). Phacomatosis cesioflammea is identical with tinguish the various types of phacomatosis pigmento- the traditional types IIa and IIb; phacomatosis spilo- vascularis (PPV), which has previously been classified rosea corresponds to types IIIa and IIIb; and phacoma- by numbers and letters that are difficult to memorize. tosis cesiomarmorata is a descriptive term for type V. A categorical distinction of cases with and without extra- Study Selection: Published case reports on PPV were cutaneous anomalies seems inappropriate. The tradi- reassessed. tional type I does not exist, and the extremely rare traditional type IV is now included in the group of un- Data Extraction and Data Synthesis: A critical re- classifiable forms. view revealed that only 3 well-established types of PPV so far exist. To eliminate the cumbersome traditional clas- Conclusion: The proposed new classification of PPV by sification by numbering and lettering, the following new using 3 descriptive terms may be easier to memorize com- terms are proposed: phacomatosis cesioflammea (blue spots pared with the time-honored grouping of in part not even [caesius=bluish gray] and nevus flammeus); phacoma- existing subtypes by numbers and letters. tosis spilorosea (nevus spilus coexisting with a pale- pink telangiectatic nevus),