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Direct Thermal Extraction Analysis of Food Packaging Material Laurel Vernarelli, Jackie Whitecavage, and John Stuff, Gerstel, Inc

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Direct Thermal Extraction Analysis of Food Packaging Material Laurel Vernarelli, Jackie Whitecavage, and John Stuff, Gerstel, Inc Volume 17 Number 5 May 2019 www.chromatographyonline.com TSKgel® FcR-IIIA-NPR Affi nity Column A New Tool for Quick ADCC Activity Assessment Mid activity Low activity High activity ABS 280nm Analyzing Pesticides in Spinach Using 0 5 10 15 20 Retention time (minutes) GC×GC–TOF-MS Separation of mAb glycoforms according to their affi nity to Fc receptor/ADCC activity • Faster and less expensive than current ADCC activity Flavonoidassays Profi ling • Easy and reproducible HPLC analysis based on FcJIIIa receptor affi nity of mAbs with a Structure- n • Unique glycoprotein elution profi le of IgG allowsBased assessment MS Approach of ADCC activity Determination of Lurasidone Metabolites in Urine with Untargeted www.tosohbioscience.com LC–HRMS magentablackcyanyellow ES83495_LCGCCTMS0519_CVTP1_FP.pgs 05.03.2019 20:02 UBM TSKgel FcR-IIIA-NPR Affi nity Column Versatile Method Applicable Cell culture monitoring to Both Purifi ed Sample and Supernatant Day 4 Day 6 HPLC analysis of two lots of a therapeutic antibody Lot A Lot B Day 8 8 8 7 7 Peak 2 Peak 2 6 6 Day 10 41% 36% 5 5 Peak 1 Peak 1 42% 3 34% Peak 3 3 Day 12 26% Peak 3 3 3 22% 2 2 Day 14 Detector response (mAU) 1 Detector response (mAU) 1 0 5 10 15 20 25 30 0 0 Retention time (minutes) -1 -1 CHO cell culture was kindly provided by Manufacturing 0 5 10 15 20 0 5 10 15 20 Technology Association of Biologics. Retention time (minutes) Retention time (minutes) Can be used in many phases of development and production: • Cell line screening in early R&D • Biosimilar/originator comparison • Upstream development and optimization • Monitoring of glycoengineering • Lot-to-lot comparison in QC TSKgel and Tosoh Bioscience are registered trademarks of Tosoh Corporation. www.tosohbioscience.com magentablackcyanyellow ES83496_LCGCCTMS0519_CVTP2_FP.pgs 05.03.2019 20:02 UBM Volume 17 Number 5 May 2019 www.chromatographyonline.com Analyzing Pesticides in Spinach Using GC×GC–TOF-MS Flavonoid Profi ling with a Structure- Based MSn Approach Determination of Lurasidone Metabolites in Urine with Untargeted LC–HRMS Conduct Critical Qualitative and Quantitative Analysis with )GPWKPG%QPƂFGPEGCPF'CUG Shimadzu’s research-grade LCMS-9030 quadrupole VKOGQHƃKIJV 361( OCUUURGEVTQOGVGT combines the GPIKPGGTKPI&0#HTQOQWTRTQXGPVTKRNGSWCFTWRQNG .%/5/5 RNCVHQTOYKVJRQYGTHWNPGY61(CTEJKVGEVWTG VQVTCPUHQTOJKIJOCUUCEEWTCE[YQTMƃQYU6JGTGUWNVKUC U[UVGOVJCVFGNKXGTUJKIJTGUQNWVKQPCEEWTCVGOCUU FGVGEVKQPYKVJKPETGFKDN[HCUVFCVCCESWKUKVKQPTCVGU Learn more about Shimadzu’s Q-TOF LCMS-9030. Call (800) 477-1227 or visit us online at www.ssi.shimadzu.com 5JKOCF\W5EKGPVKƂE+PUVTWOGPVU+PE4KXGTYQQF&T%QNWODKC/&75# The power of polymeric columns Polymer HPLC columns have a lot of benefits. They don’t require any functionalization for reversed-phase separations, and rigid polymeric supports intrinsically resist chemical and pH degradation, a fundamental problem with silica columns. Plus, polymer’s inertness to most chemical environments makes it a robust and economical solution. Hamilton offers a line of pH stable polymer HPLC columns for reversed phase, anion exchange, cation exchange, and ion exclusion separations perfect for pharmaceuticals, small molecules, proteins, peptides, DNA, organic, and inorganic ions, and more. 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