5/25/2011

Whenis not Formula=Breastmilk? contraindicated

JackNewman,MD,FRCPC JackNewman,MD,FRCPC

AA crucial question Isformulaalmostlikebreastmilk?

 Isformulareallyverynearto,oralmostlike  Howcanitpossiblybe? breastmilk?  Wedon’treallyknowwhatisinbreastmilk  Ifitis,itisdifficulttoexplainanyhealthrisksto  Thereisnosuchthingasa standard breastmilk artificialfeeding  Eventheformulacompaniesadmitthatnotall  Butisitreallyveryneartooralmostthesameas babiesneedexactlythesamestuff breastmilk?  And,ofcourse,willusethisnotiontomarkettheir  No! formulas(specialformulasforspecialbabies)  Evennow,formulaisonlysuperficiallysimilarto  While,atthesametimeconvincingusthatformula breastmilk isis virtuallythesameasbreastmilk  Thereisnoquestionaboutthis !!  But different andbetterthantheformulasoftheir competitors,whicharealsovirtuallythesameas breastmilk

Quotefrom: TravelsinHyperreality Breastmilkvaries byUmbertoEco

 ...theAmericanimaginationdemandsthereal  Fromwomantowoman thingand,toattainit,mustfabricatetheabsolute  Dependingonthebaby’sgestationalage fake;  Withthe’sdiet  Withthetimeofday  Withthelengthoftimeafterbirth  Duringasinglefeeding  Withwhichisofferedfirst  Withthetimeofthemother’smenstrualcycle  Withthenumberofpreviouspregnancies  Dependingonhowtheisobtained

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Variationinfatcontentduringa Diurnalvariationofbreastmilk singlefeeding

Variationinlysozymeover18months But…

Numberofconsecutivesamplingdaysrequiredfor Onesampleisnotenough eachwomantoobtainastableestimate

 DhonuksheDhonuksheRuttenRAM,VossenaarM,WestCERuttenRAM,VossenaarM,WestCE etal .Day.DaytotoDayvariationinIron,andDayvariationinIron,Zincand CopperinbreastmilkofGuatemalan. JJ PediatrGastroNutr 2005;40:1282005;40:1283434

2 5/25/2011

Theformulafedbabyneedsmoreand Whatisanadequatesample? morewithincreasingageandweight

 Wedon’tknowthiseither  Wenowknowthatthebreastfedbabyisgetting  Manyoldstudies(uponwhichwestillrely)used less thanwepreviouslythought,muchlessthan “drippedmilk” theformulafedbaby  Ispumpedmilkthesameasthatwhichthebaby  The exclusively breastfed, wellgaining 5month getswhenhe’sonthebreast? oldisgettingonly, atmost ,10,1015%moremilkthan15%moremilkthan theexclusivelybreastfed,wellgaining1monthold, eventhoughthe5montholdistwiceasheavy

Really?Isthatpossible? isawonderfulfluid

 See: Kent,J.C.,Mitoulas,L.R.,Cox,D.B.,Owens,  MoreNa,K,Cl,protein,fatMoreNa,K,Cl,protein,fatsolublevitaminssolublevitamins R.A.andHartmann,P.E.Breastvolumeandmilk  Moreminerals productionduringextendedinwomen  Richinimmunoglobulins,especiallySIgA ExperimentalPhysiology 1999;84:4351999;84:435447447  Richincells(100,000Richincells(100,0005,000,000leukocytesperml)5,000,000leukocytesperml)  DuringthisperiodofexclusivebreastDuringthisperiodofexclusivebreastfeeding,24feeding,24hh  Higherpercentageoffatisdocosahexaenoic, milkproductionfromeachbreastremained arachidonicandlinolenicacids relativelyconstant(453.6 ±± 20.1g,nb=48),and storagecapacitywas209.9 ±± 11—0ml(nb=46)  Theycomparedmilkproductionbythemother between1and6monthsofage

Inaddition,colostrum…

 Facilitatesestablishmentof L.bifidus florainGI tract  Facilitatesexpulsionofmeconium  Isthebest“treatment”forpreventing hypoglycæmiaandhyperbilirubinæmia

3 5/25/2011

Adforformula

Sowhyleaveoutalltheother importantingredients?

Adoublestandard? What’smissinginbreastmilk?

 Thereisalotofblahblahblahaboutwhat’s 1.1. Iron? missinginbreastmilk  No,thereisjusttherightamountofironin  Butwedon’ttalkmuchaboutwhat’smissingin breastmilk formula  Togetherwiththestoresthebabygetsatbirth, probablythereisenoughtokeepthebabyiron  Maybebecauseitwouldtakeallday sufficientforupto6to9months 2.2. VitaminD?  Thebreastmilkdoesnotneedtosupplyvitamin DD

GettingfreevitaminD What’smissingfromformula? (TorontoinFebruary)

 Whataboutcolostrum?  WheredoIbuySimilostrum?  Enfalostrum?  GoodStartostrum?

4 5/25/2011

Whichformulaisclosesttowhich Breastmilkvarieswiththelengthof colostrum? timeafterbirth;considerthisemail

 Ihadacalltodayfromawomanwhosesisterwho isadruguser deliveredababytoday.Thebaby remains inhospital andisbeingtreatedfordrug withdrawal.Themotherhasabandonedthe infant andthebabywillbecaredforbyanaunt. Myquestionisthis: thecaregiverwantsto breastfeedthisnewbornassheisstillnursingher own11monthold.Ishermilkappropriateforthis infantorshouldthebabybesupplementedat breast aswell?

So,shouldthisbabybe supplementedwithformula?

 Why?  Inwhatwaydoesformulabecomemore appropriateforsupplementingcolostrumthanthe milkofamotherwhoisbreastfeedingan11month old?  Therewegoagain,believingformulaisagood copyofbreastmilk  Whatagewasthecalfwhosemotherprovidedthe milktomaketheformula?

Whitecells?

5 5/25/2011

ImmuneFactorsinBreastmilk

Breastmilkmadetomeasure

Andthesearenotevenallofthe immunefactorswhicharepresentin breastmilk,butabsentfromformulas

6 5/25/2011

Ifthemotherhasautoimmunedisease,can shepassonillnesstothebabyinthrough Oligosaccharides antibodiesinhermilk? 1.1. Thepredominantimmunoglobulininhuman milkissecretoryIgA,butthereisnoevidence thatsecretoryIgAisapathogenicantibodyin autoimmunedisease 2.2. Inanycase,secretoryIgAisnotabsorbedviathe gastrointestinaltract 3.3. ThereisnoevidencethatIgGinhumanmilkis absorbedintothecirculationoftheinfant 4.4. IgMalsoexcludedfromtheinfant’scirculatory system

Formulacontainsthesameamount ofproteinasbreastmilk

 Breastmilkcontains8to15g/Lofprotein  Thisissomewhatlessthanmostformulas(most contain15g/Lor more ))  But:  Upto60Upto6065%(about5g/L)oftheproteinin65%(about5g/L)oftheproteinin breastmilkislactoferrin,whichisnotabsorbed fromthegut!  About0.5g/Loftheproteinisimmunoglobulin, whichisalsonotabsorbedfromthegut! formulacontainswaytomuchprotein

7 5/25/2011

WhataboutS100Bprotein? Stemcellsinbreastmilk

 S100BisanacidiccalciumS100Bisanacidiccalciumbindingproteinofthebindingproteinofthe  See: EFEFhandfamily,characterizedbythemosthandfamily,characterizedbythemost  CreganMD,FanY,Applebee,A, etal. commoncalciumbindingmotifofahelixcommoncalciumbindingmotifofahelixlooploop IdentificationofnestinIdentificationofnestinpositiveputativemammarypositiveputativemammary helixstructure stemcellsinhumanbreastmilk CellTissueRes  Whateverthatmeans (2007)329:129(2007)329:129––136136  Itmaybeimportanttobraindevelopment  Presentinmuchhigherconcentrationsin breastmilk thaninformula(andhigherinmature breastmilk thanincolostrum thanin colostrum))

Yogurtclosesttobreastmilk?

Sowhat’sthisallabout? Isitgoodorbad?

 Ifthisisformula,it’sneithergoodnorbad  Ifit’sbreastmilk,it’sprobablygood,butwhy?  Breastmilkisfullofimmunefactors(andnotjust immunoglobulins)  Theimmunefactorslinethebabiesupper respiratorytractanduppergut,likelyprotecting thebabyagainstinfection  Soifthebabyaspiratesbreastmilk?  formula=breastmilk?

8 5/25/2011

That’snice,butdoesitmakea APerfectExample differencetothebaby?  Youbetitdoes!  Manydidnotbelievethatthelongchainedpolyunsaturated fattyacidsinbreastmilkcouldmakebabies“smarter”  Thestudiesareallthere,it’sjustthatsomany peopleprefernottobelievethembecausethey  Maybetheydon’t don’tliketobelievethem  Butwhentheformulacameoutwiththeirnewformula,I haveheardpædiatricianshavesaid“Nowformulaisjustas  Assoonas one studycomesoutdoubtingthe goodasbreastmilk” resultsof many studies,wehear“Yousee?  LongchainedPUFA’smakebabiessmarteronlywhenthey Formulaisjustasgood!” areinformula?  Studiesshowingrisksofformulaareneveraswell  CheckoutMeadJohnson’swebsiteforthe“breastmilk formulaformulaEnfamil”:Grosslyunethicalmarketing!Enfamil”:Grosslyunethicalmarketing! doneasstudiesshowingnorisk… http://www.enfamil.com/app/iwp/enfamil/productDetail .do?dm=enf&id=.do?dm=enf&id= 10733&iwpst=B2C&ls=0&csred=1&r=3422101508

Oh,andonemorethingformulais Infact… missing…

 NoevidencethatsimplyaddingDHAandARAto  Breastfeeding! formulagivesthebenefitit’ssupposedto  HowcouldIforgetthat?  ThesePUFA’sneedtobeaddedincorrect  Becauseinthemindoftheaveragepersoninan proportions,andtheyarenotabsorbedfrom industrializedsociety… formulainthesamewayastheyarefrom breastmilk Bottlefeeding=Breastfeeding  Studiesdonotsupportanybenefitwhenaddedto formula  See http://cornucopia.org/DHA/DHA_FullReport.pdf

9 5/25/2011

Howbreastfeedinghelpsprevent adultheartdisease

 TosckeAM etal .Overweightandobesityin6.Overweightandobesityin6toto 1414yearyearoldCzechchildrenin1991:ProtectiveeffectoldCzechchildrenin1991:Protectiveeffect ofbreastofbreastfeedingfeeding JPediatr 2001;141:7642001;141:76499  vonKriesR etal .(1999)Breastfeedingandobesity: crosssectionalstudy BrMedJ 1999;319:1471999;319:147150150  RavelliAC etal .Infantfeedingandadultglucose tolerance,lipidprofile,bloodpressure,andobesity ArchDisChild 2000;82:2482000;82:2485252

Howbreastfeedinghelpstoprevent Formula:aheavymetalcocktail adult cardiacdisease

 ArmstrongJ etal .Breastfeedingandloweringtheriskof childhoodobesity Lancet 2002;359:20032002;359:20030404  OwenCG etal .InfantFeedingandBloodCholesterol:A StudyinAdolescentsandaSystematicReview 2002;110:5972002;110:597608608  SinghalA,ColeT,LucasA.Earlynutritioninpreterm andlaterbloodpressure:twocohortsafter randomisedtrials Lancet 2001;357:4132001;357:41399  MartinRM,NessAR,GunnellD,EmmettPE,SmithGD fortheALSPACStudyTeam.Doesbreastfeedingininfancy lowerbloodpressureinchildren Circulation 2004;109:12592004;109:1259 6666

Toomuch…

 Toomuchaluminum  Cowmilkformula100x  Soyformulaupto2000x  Toomuchmanganese  Toomuchlead  Toomuchcadmium  Toomuchiron

10 5/25/2011

Errorsininfantformulas

Recallsofinfantformulas Recalls(continued)

 1978  1981  Enfamilcontaminatedwith E.coli  Enfamilrecalled(excesssolvents)  1979  1982  SMArecalled(improperhomogenization)  SMA,Nursoyrecalled(lackVitaminB6)  NeomulsoyandCHOfreecausedhypochloremic alkalosis  SMArecalled(containedblackmaterial)   1980 SMAhadbadodorandfatseparated  SoyalaccontainedtoomuchVitaminD  Enfamilrecalled(sour,green,curdled)

Recalls(continued) Recalls(continued)

 1983  1984  Soyalacrecalled(problemwithVitaminAstability)  NeoNeoAgAgU(Taiwanese)deficientincalciumU(Taiwanese)deficientincalcium   Naturlacrecalled(absencethiamine,copper, DeDelactInfantfoundtocontaincalciumcalceinalactInfantfoundtocontaincalciumcalceinatete VitaminB6) (believeddangerousforinfants)  Enfamilcontains Enterobactercloacae  Similac,Isomilfoundtocontaincarcinogens (trichloroethyleneandparchorethylene)

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Recalls(continued) Recalls(continued)

 1985  1986  KamaKamaMilrecalled(deficientfolicacid,zincandMilrecalled(deficientfolicacid,zincand  Soyalacrecalled(progressivedegradationof VitaminD) VitaminA)  NutraNutraMilkrecalled(nutrientdeficiencies)Milkrecalled(nutrientdeficiencies)  1993  GerbermeatGerbermeatbasedformularecalled(excessbasedformularecalled(excess VitaminD)  SoyalacandEnfalacrecalledinCanada(bacterial contamination)  CarnationevaporatedmilkinAustraliamislabeled Prosobee  LabelingerroronSimilac

FDAALERTSPUBLICREGARDING RECALLOF POWDEREDINFANTFORMULA (November1,2002):see http://www.fda.gov/bbs/topics/NEWS/2002 /NEW00849.html

12 5/25/2011

Anotherrecall(February2005) And…

 SimilacAdvancewithIronpowderedinfant  Forthosewhoarefondofexoticfoods… formula  Interestingfoodthathasbeenfoundininfant  FDAandtheRossProductsDivisionofAbbott Laboratoriesannouncedarecall…duetothe formulas: presenceofblackplasticparticlesreportedina oo Rathair smallnumberofcans.Theparticlesaretheresult ofanisolatedmanufacturingeventthathasalready oo Piecesofglass beencorrected.Noserioushealthorsafetyreports oo Melamine havebeenreceivedthatareattributedtothis situation.  duetoadulterationofmilkbygreedypeople  http://www.fda.gov/medwatch/SAFETY/2005/s  We’veforgottenalready! afety05.htm#Similac

Wethinkweprogress! ,1902France,1902——adulteratedmilkkillsadulteratedmilkkills

Othersourcesoferror

 Errorsby  ConcentrateinsteadofreadyConcentrateinsteadofreadytotouseuse  MixingErrors oo 16%inonestudy oo Likelihoodincreasedwhensuppliedbyfoodbank

13 5/25/2011

Risksforthemother Breastcancer

 Ovariancancer  Womenwhobreastfeedarelesslikelytodevelop breastcancer  Endometrialcancer  CollaborativeGrouponHormonalFactorsin  Breastcancer BreastCancer.Breastcancerandbreastfeeding:  Osteoporosis collaborativereanalysisofindividualdatafrom47  Irondeficiency epidemiologicalstudiesin30countries,including 50,302womenwithbreastcancerand96,973  Delayedinvolutionoftheuterus womenwithoutthedisease Lancet 2002;360:1872002;360:187 195195  Thisstudybringstogether>80%oftheworldwide epidemiologicaldataonbreastcancerand breastfeeding

Whatdoesthismean?

 “About470,000womenindevelopedcountriesand 320,000womenindevelopingcountrieswere diagnosedwithbreastcancerin1990”  “Basedonestimatesobtainedhere,ifwomenin developedcountrieshad2.5childrenonaverage, butbreastfedeachchildfor6monthslongerthan theycurrentlydo,about25,000(5%)breastcancers couldbepreventedeveryyear,andifeachchild werebreastfedforanadditional12months,about 50,000(11%)breastcancersmightbeprevented everyyear”

Morematernalrisks

 Difficultywithweightloss  Disempowerment  Increaseddifficultyinattachmentwithbaby  Cost

14 5/25/2011

Type2diabetes Type2diabetes,anotherstudy

 StuebeAM,RichStuebeAM,RichEdwardsJW,WillettWC,EdwardsJW,WillettWC, etal ..  LiuB,JormL,BanksE.Parity,breastfeedingand Durationoflactationandincidenceoftype2 thesubsequentriskofmaternaltype2diabetes diabetes JAmMedAssoc 2005;294:26012005;294:260126102610 DiabetesCare 2010;33:12392010;33:123912411241  “Longerdurationofbreastfeedingwasassociated  “Otherlargeprospectivestudiessuggestrisk withreducedincidenceoftype2diabetesin2large reductionofabout15reductionofabout1520%peryearoflactation(120%peryearoflactation(1 cohortsofwomen” 3);ourfindingsconcurwiththisestimate”

Metabolicsyndrome Whatismetabolicsyndrome?

 RamK,BobbyP,HailpernS, etal. Durationof  Themetabolicsyndromeisaclusteringofthe lactationisassociatedwithlowerprevalenceofthe metabolicabnormalities: metabolicsyndromeinmidlifemetabolicsyndromeinmidlife——SWAN,thestudySWAN,thestudy ofwomen’shealthacrossthenation AmJObstet  Insulinresistance,dyslipidemia,hypertension,and Gynecol 2008;198:268.e12008;198:268.e1268.e6268.e6 obesity  “Durationoflactationisassociatedwithlower  Womenwithmetabolicsyndromeareatincreased prevalenceofMetSyninadoseprevalenceofMetSyninadoseresponsemannerresponsemanner riskofdiabetesmellitus,majorcardiovascular inmidlife,parouswomen” events,andincreasedallevents,andincreasedallcausemortalitycausemortality

EnoughformulatocovertheSahara Riskstosociety Desert?

 Formulaasanenvironmentalhazard  Thinkwhatthatmeansinenvironmentalterms!

 Lossofcontraceptiveeffect  http://www.youtube.com/watch?v=http://www.youtube.com/watch?v=XOCYLxfRNUXOCYLxfRNU  Lossofsecurity,stablebeginningforthechild  Andthat’sjustonecompany

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17 5/25/2011

Westernprejudice[assumes]artificial areinnocentuntilprovenguilty,whereas breastmilkisguiltyuntilproveninnocent.

RVShort,1988

Advertisingwouldn’tleadusastray!

Whenisbreastfeeding not contraindicated

Hardlyeverisbreastfeeding contraindicated!

ArtificialBabyMilks areonlyapproximations Breastfeedingis more than tooutdatednotionsofwhat Breastmilk we think breastmilkis(was)

18 5/25/2011

Fromanemail…

 “Sheisstillveryattachedtonursing,stillnursesat leastthreetimesadayandduringthenight,since wearecosleeping(sobasically,ondemand).Ihad triedtoexplaintoherthatwearenotnursing anymoreatnighttostarther,butshewill nottakeanythingbutthebreast. Lastnightshe crieduntilshegotthebreastfinally,andthenshe wouldnotletmego.”

Formulas

 Occasionallysavelives  Canbeusefultherapeutically BreastfeedingandMaternal But! Medication  Theyshouldbeconsidereddrugs,withpossible shortterm,mediumtermandlongtermside effects  Andusedonlyif necessary

19 5/25/2011

Drugsaregenerallysaferfornursing Principlesofdruguse babiesif…

 Usemedicationonlyifnecessary  Highlyproteinbound  Useolder,betterknowndrugs  ShorthalfShorthalflifelife  Usedrugswhichareleasttoxic  PoorlyabsorbedfromGItract  Usedrugswhichareusedforinfants  Largevolumeofdistribution  Beflexible,lookforalternatives  Watersoluble,acidic,ionized  Largemolecularweight  Shortexposure

Example Example

 Abreastfeedingmotherneedstousesomethingfor  Informationonthreedrugs(accordingtoHale) arthritis Halflife:  ItisdecidedthatanonItisdecidedthatanonsteroidalantisteroidalantiinflammatoryinflammatory  Ibuprofen:T½=1.8Ibuprofen:T½=1.82.5hours2.5hours drugisbestatthistime  Ketorolac:T½=2.4Ketorolac:T½=2.48.6hours8.6hours  Forthesakeofargument,letusconsiderthree  Naproxen:T½=12Naproxen:T½=1215hours15hours possibilities Proteinbinding:  ibuprofen(Advil,Motrin),ketorolac(Toradol),  Ibuprofen:>99% naproxen(Anaprox,Naprosyn)  Ketorolac:99%  Naproxen:99.7%

Example Example

 Informationonfourdrugs(accordingtoHale) 1.1. Proteinbinding: Halflife:  Ketorolac:99%  Ketorolac:T½=2.4Ketorolac:T½=2.48.6hours8.6hours  Ibuprofen:>99%  Ibuprofen:T½=1.8Ibuprofen:T½=1.82.5hours2.5hours  Naproxen:99.7%  Naproxen:T½=12Naproxen:T½=1215hours15hours  Diclofenac:99.7%  Diclofenac:T½=1hour 2.2. Halflife:  Ketorolac:T½=2.4Ketorolac:T½=2.48.6hours8.6hours  Ibuprofen:T½=1.8Ibuprofen:T½=1.82.5hours2.5hours  Naproxen:T½=12Naproxen:T½=1215hours15hours  Diclofenac:T½=1.1hour

20 5/25/2011

But… Therealquestionis…

 Almostallaresafeforthebaby  Whichissaferforthebaby?  Somearesaferthanothers  Breastmilkwithatinyamountofmedication(and  Withveryfewexceptions ,breastfeedingcanand itisalmostalwaystiny),or should continue!  Formula  Theanswer, withveryfewexceptions ,is breastmilkwithalittlebitofmedication  Takeintoaccounteverythingwhichhasbeensaid inthebreastmilkvsformula

Not contraindicated! Radioactiveiodine

 Metronidazole  Avoidifatallpossible( not necessarytodoscanto  Prednisone differentiatepostpartumthyroiditisfromGraves’ Disease)  Alcohol  Delayaslongaspossibleiftrulynecessary  Interferon  UseI¹²³insteadofI¹³¹(I¹²³requiresonly12to24  Nicotine(inanyform) hoursinterruptionofbreastfeedingdependingon  Etanercept(Enbrel),Infliximab(Remicad),andall dose) otherantibodiesusedtherapeutically  Mothershouldexpressmilkinadvancesobaby  Tetracycline cangetbreastmilk,notformula  Vaccines  IfI¹³¹mustbeused,thereisonepossibility…

I¹³¹ Theremaybeanotherissue

 TheonlytimeI¹³¹ mustbeused ,isfortreatingfor  Isitpossiblethatradioactiveiodinecoulddamage possiblemetastasesofcarcinomaofthethyroid thealveolarcellsofthebreast,thosemilk (butdoesit really needtobedone?) producingcells,andcompromise future milk  Ifthemotherhasnothyroidtissue(ormetastases), theradioactiveiodinewillbequicklybeeliminated production? fromherbody  Therearethosethatsuggeststopping  Expressmilk(tohelpgetridofiodine) breastfeedingatleastaweekbeforethemother  Onecancheckforradioactivityfromtimetotime getsradioactiveiodine andrestartbreastfeedingwhengone  Howmanymothersaredriedupafteraweek?  Radioactivityinthemilkdecayssoevenmilkthat containsradioactivitycanbesavedandusedlater  Theoreticalconcernonly,notproved

21 5/25/2011

I¹²³ PostpartumthyroiditisvsGraves’disease

 Thisradioisotopehasamuchshorterhalflifeand  Ifthemotherpresentswithsymptomsof requiresstoppingbreastfeedingonly12to24 hyperthyroidism,treatsymptomaticallyandfollow hours,dependingonthedose herthyroidfunction  Ifascanisabsolutelynecessary,bettertousethis  Usuallywithinsixweeksorso,thethyroidfunction radioisotope willbenormalizingwithpostpartumthyroiditis  Butisitreallynecessary?!  (themostlikelydiagnosisforanursingmother4or 5monthspostpartum)

Otherscansusingradioactivetracers Technetium

 Avoidifpossible  Thismostcommonofradioactiveisotopeshasa  DoinganMRIorCTscanorsomeothertestratherthana halflifeof<6hours radioactivescanisoftenfeasible   e.g.multie.g.multisliceCTtechnologynowreplaceslungssliceCTtechnologynowreplaceslungscanforcanfor Therefore98%ofitisoutofthemother’sbody diagnosisofpulmonaryembolus within5halflives(30hours)  Butifit’sunavoidable…  Sowhydosomanyradiologiststellthemotherto  Themothershouldexpresshermilkinadvancesothatthe stopbreastfeedingfor48orevenmorehours? babycanatleastgetbreastmilkinsteadofformula   Milkexpressedafterthetestuntilthemotherrestarts Actually75%willbeoutofthemother’sbodyin12 breastfeedingcanbesavedandcanbeusedafterwaiting hours untilradioactivityhasdecayedaway  Inmyopinion,12hoursislongenough

HIDAscan Emergencylungscan

 Donewithtechnetiumtolookatthegallbladder.  Themotheris1daypostpartum,presentswith  Technetiumisradioactive,somotherhastostop symptomsandsignsofapulmonaryembolus breastfeeding,right?  Alungscanisnecessary!  Wrong!  Forhowlongafterthescandowestop  Sincetheisotopeistrappedinthegallbladder,and breastfeeding? thenexcretedintothemother’sgut,itdoesn’tget  Whystop? intothemilk  Afterall,theamountofcolostrumthebabygetsis  (Theisotopeisattachedtoacarrierwhichtakesit verysmall,andthustheamountoftechnetium tothegallbladder) also!

22 5/25/2011

But,nevermindtheemergencylung MRIscan scan

 FromthechiefofradiologyataTorontohospital  Contrastmaterialisgadopentetate (communityhospital, not tertiarycare)  Theamountthatisexcretedintothemilkis0.04%  ThenewmultisliceCTtechnologynowallowsus ofthematernaldose todononinvasiveCTangiographywhichisas goodasregularangiography  Theamountabsorbedfromthegastrointestinal tractis0.8%oftheingesteddose  WehavenowreplacedNuclearMedlungscans withCTpulmonaryangiogramswhichtakeabout  Thehalflifeofthematerialis1.6hours 15secondstoperformcomparedwiththeV/Q  Weusethisforbabies,evenpremature scanswhichtakeabout30minutesandarenot nearlyasaccurateorspecific(unlesstheyare normal)

FromtheAmericanCollegeofRadiology Asforothercontraststudies (October2001)

 ThematerialusedforCTscanisiodinebasedand  Youwillbeprovidedwiththisdocument isacomplexsubstancewhichwillnotgetintothe  Becauseofitslowlipidsolubility,lessthan1percentofthe milk administeredmaternaldoseofiodinatedcontrastmedium isexcretedintothebreastmilkinthefirst24hours. 1,21,2  Theamountofiodinewhichgetsintothemilk Becauselessthan1percentofthecontrastmedium afterIVP,lymphangiogram,etc,isverysmall,and ingestedbytheinfantisabsorbedfromitsgastrointestinal tract, 33 theexpecteddoseabsorbedbytheinfantfromthe willhardlyincreasetheamountofiodineinthe breastmilkislessthan0.01percentoftheintravascular milkoverwhatisalreadythere dosegiventothemother.Thisamountofcontrastmedium representslessthan1percentoftherecommendeddosefor aninfantundergoinganimagingstudy,whichis2mL/kg.

FromtheAmericanCollegeofRadiology (October2001)

 Likeiodinatedcontrastagents,gadoliniumcontrastagents haveaplasmahalfhaveaplasmahalflifeofabout2hoursandarenlifeofabout2hoursandarenearlyearly completelyclearedfromthebloodstreamwithin24hours. Lessthan0.04percentoftheintravasculardosegiventothe Drugsofrecreationandabuse motherisexcretedintothebreastmilkinthefirst24 hours. 4466 Becauselessthan1percentofthecontrast mediumingestedbytheinfantisabsorbedfromits Theprinciplesarethesame gastrointestinaltract, 77 theexpecteddoseabsorbedbythe infantfromthebreastmilkislessthan0.0004percentofthe intravasculardosegiventothemother.

23 5/25/2011

Alcohol Whatistheconcern?

 Goesbackandforthintomilkfromthemother’s  Ifthemotheristoodrunktotakecareofherbaby, bloodandispresentinthemilkinthesame thisisanotherissue,butthisdoesnotmakethe concentrationasinherblood milkitselfdangerous  Whiskyhas40%,wine12%,beer3Whiskyhas40%,wine12%,beer35%alcohol5%alcohol  Onestudyshoweddecreasedmotoractivityin  LegalbloodlimitinOntario0.08% babieswhosemothersweredailyheavyusersof alcoholwhilebreastfeeding,buttookthemothers  Ifthemotherhas0.08%alcoholinherblood,her milkwillhave0.08% wordforitthattheydidnotdrinkduringthe pregnancy(duh!)  Thisisnothingandisnotaconcern  Decreasedmilksupplywithalcoholuse(noproof ofthisatall)

Marijuana

 Thebreastdoesnotknowthatadrugisillegalor not TheissueisnotmostlytheTHCinthe  Marijuanadoesnotactdifferentlyfromotherdrugs  Inotherwords,verylittlegetsintothemilk milk,butrather,ifthemotherisa  Ifthemotherisaconstantheavyuser,thisisa constantheavyuser,canshetakecareof differentsituation,becausethedrugwilleventually herbaby? accumulateinthebaby’sbodystores  Whatisthesignificanceofthat?  Nobodyknows

Heroin,cocaine,methamphetamine, Methadone others

 Verylittlegetsintothemilk,justaswithanyother  Thisisamoredifficultproblem drug  Regularusersofharddrugsrarelybreastfeed  Evenlargedoses,say120mgaday+,doesnotget  Buttheirbabiesareathighriskofillness intothebabyinsignificantamounts morbidityandmortality  Thereisnomaximumtherapeuticdoseoverwhich  Shouldthebabybeapprehended? breastfeedingiscontraindicated  Ifnot,shouldweencouragebreastfeeding?  Certainly,thebabygetslessexposurethanduring thepregnancy  Weshouldencouragethemothertobreastfeed

24 5/25/2011

Possibleapproach? It’snotadonedeal

 Ifwetellapregnantwoman“youcanonly  Ofcourse,somewillcontinuetouse breastfeedifyoustopusing”,shewon’tstop,  Welookatthesituationagain usually,thebabywillbeapprehended,often,the motherwillremainaddicted  Theexperienceofencouragingwomento  Buthavingababy andbreastfeeding canbealife breastfeedinrehabilitationclinicsinAustraliais changingexperience verypositive  Ifwesaytoher“Hereisachanceforyouto changeyourlifesobreastfeed,butstopusing”,the motherjustmaygotorehabilitationand methadone  Ifnot,well,wereIfnot,well,wereevaluatethesituation,butweevaluatethesituation,butwe shouldseizethisopportunity

Thebabyinwithdrawal Infantillness

 Ifthebabyisshowingsignsofnarcoticwithdrawal shouldwerefusetogivethebabythemother’s milk?  Wewillgivethebabyopium,paregoricor morphine,butweworryaboutthetinyamountof narcoticinthemilk?  Thereisnotenoughnarcoticinthemilktoprevent withdrawal(onerecentstudysuggestsyoucan diminishthesymptomsbybreastmilkor breastfeedingbreastfeeding——Pediatrics 2006;117:11632006;117:11639)9)  ThisisalsotrueforwithdrawalfromSSRI antidepressants(e.g.paroxetine)

Breastfeedingis best for… Maternalillness

 Prematurebabies(often without fortifiers!)  Gastroenteritis  Respiratoryillness  Cleftpalate,otheranatomicabnormalitiesofthe face(atleast breastmilk ))  Metabolicdiseases(some)  Hyperbilirubinemia  Failuretothrive  Ahospitalizedchildneedsbreastmilk…and breastfeeding more notless

25 5/25/2011

Continuebreastfeeding… Andwhatabout…?

 Fever,cough,diarrhea,rash,etc.  Chickenpox  ,breastabscess  WestNileVirus  Otherbreastissues,e.g.,breastaugmentationor  HepatitisA,B,C…Z reduction  Rubella  Postpartumthyroiditis(seepreviousdiscussion)  Cytomegalovirus  Radioactiveisotopes(seepreviousdiscussion)   Etcetera!  HIV

Animportantstudy Results

 CoutsoudisA,PillayK,KuhnL,SpoonerE,Tsai  Exclusive breastfeedingdoesnotseemtoincrease WWY,CoovadiaHMY,CoovadiaHM etal. Methodoffeedingand riskoftransmissionofHIVmorethan exclusive transmissionofHIVtransmissionofHIV1frommotherstochildrenby1frommotherstochildrenby formulafeeding 15monthsofage:prospectivecohortstudyfrom  Infact,theremayevenbeaprotectiveeffect Durban,SouthAfrica AIDS 2001;15:3792001;15:3798787  Partial breastfeedingwithanysupplement significantlyincreasestheriskoftransmissionof HIV

Twomorestudies! Othersituations

 Thisstudy,withlargernumbers,helpstoconfirm 1.1. Anewpregnancy thepreviousstudybythepreviousstudybyCoutsoudisCoutsoudis::  Noevidenceforincreasedriskofdamagetothe  Iliff PJ,PJ,PiwozPiwoz EG,EG,TavengwaTavengwaNV, etal. Early fœtusorspontaneousabortion exclusivebreastfeedingreducestheriskof  See:IshiiH.Doesbreastfeedinginduce postnatalHIVpostnatalHIV1transmissionandincreasesHIV1transmissionandincreasesHIV spontaneousabortion? JObstetGynaecol freesurvival AIDS 2005;19:6992005;19:699708708 2009;5:8642009;5:864868868 2.2. Hospitalizationofthemother  LouiseKuhn1,MosesSinkala,ChipepoKankasa, etal. HighUptakeofExclusiveBreastfeedingand  Noincreasedriskofinfectiontothebabyifthe babyishospitalizedwiththemother(perhaps ReducedEarlyPostReducedEarlyPostNatalHIVTransmissionNatalHIVTransmission evenless) PLoS ONE 2(12):e1363.doi:10.1371/journal.pone.0001363

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Contactinformation

 Myemail: [email protected]  Ourwebsite: www.nbci.ca allowsfreeaccessandcontains:  informationsheetsinEnglishandsomeinFrench,afewin RussianandPortuguese  videoclipswithexplanatorytextsinEnglish,French, Spanish,Chinese,Russian,Portuguese,Italian, Indonesian,Arabic,RomanianandGerman  informationaboutourteachinginstitute,including amongstmanyotherprogrammes,adiplomacourse(click “institute”formoreinformation)

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