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Sources, Symptoms, and Signs of Arsenic Poisoning

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Sources, Symptoms, and Signs of Arsenic Poisoning Sources, Symptoms, and Signs of Arsenic Poisoning J. Thomas Hutton, MD, PhD, and Bonna L. Christians, MA Lubbock, Texas, and Minneapolis, Minnesota Arsenic poisoning continues to be a serious medical problem that may easily be overlooked or misdiagnosed. The broad constellation of symptoms and signs in arsenic poisoning, along with changing sources of this toxin, contributes to mis­ diagnosis. A re-examination of current potential sources was carried out. Sources were determined in 17 of 20 documented cases of arsenic poisoning. Fourteen cases resulted from inges­ tion of a single, commonly available, arsenic-containing ant killer. In contrast to earlier reports, this survey found that agricultural and industrial sources were relatively uncommon. A peculiar posturing of the hand is commonly seen in the early stages of arsenic poisoning prior to the development of Mee's lines or palmar hyperkeratosis. An illustrative case is reported that resulted from intermittent self-administration of an arsenic-containing ant killer in order to maintain a state of chronic invalidism. Many years have passed since the sources for to arsenic, however, has heightened concern that arsenic intoxication were investigated.1 Prior to arsenic poisoning may again be on the rise.2'4 The World War II arsenic poisoning was fairly com­ possible changing epidemiology prompted a re­ mon. At that time the widespread use of medicinal examination of this potentially avoidable health arsenic gave rise to inadvertent overdosing and hazard. provided a ready source of arsenic for attempted homicides. Arsenic poisoning also resulted from Survey of Arsenic Poisonings the widespread application of arsenic-containing insecticides to grain, fruits, and vegetables. Cur­ A case investigation was carried out using rent medical uses of arsenic are few. Agricultural postmortem laboratory results from death certifi­ applications are limited to additives for livestock cates (2 cases) and results of clinical laboratory and poultry rations. Potential industrial exposure analyses (18 cases) from the Minnesota State Board of Health. The survey covered the period from 1976 through 1979. Twenty instances of elevated arsenic levels for From the Department of Medical and Surgical Neurology, Texas Tech University Health Science Center, Lubbock, different individuals were recorded for the four- Texas, and the Division of Epidemiology, University of Min­ year period under study. Follow-up inquiries to nesota Health Science Center, Minneapolis, Minnesota. Re­ quests for reprints should be addressed to Dr. J. Thomas the referring physicians, patients, families, and lo­ Hutton, Department of Medical and Surgical Neurology, cal police revealed an identifiable source in 17 cases. Texas Tech University Health Science Center, Lubbock, TX Table 1 summarizes the sources of arsenic and 79430. ® 1983 Appleton-Century-Crofts 423 THE JOURNAL OF FAMILY PRACTICE, VOL. 17, NO. 3: 423426, 1983 ARSENIC POISONING Table 1. Documented Causes of Arsenic Poisonings* Total Accident Suicide Homicide Malingering No. (%) Terro Ant Killer 6** 5 2 1 14(82) Laboratory arsenic compound 2 2(12) Commercial insecticide 1 1(6) Total 7 7 2 1 17(100) *Source of arsenic could not be determined in three cases of poisoning **Five of these were children motivations underlying the poisoning cases. For The wife continued to cook for both of them. an additional three cases, a source could not be Medical personnel and the local police were determined. Of the 20 subjects, 14 were male and 6 unable to establish a source or definite motive. were female. Fourteen of the 17 explainable cases Following a prolonged rehabilitation effort, the (82 percent) were caused by Terro Ant Killer. Self­ patient was discharged and returned home. administration of arsenic by childhood accident or The patient was readmitted seven additional as an adult suicide attempt represented the most times over the next three years for recurrent but common type of ingestion. less severe arsenic poisoning. Typically, when his One case stands out. This was the first of three gait was returning to normal, he would again suc­ arsenic poisonings to present at the Minneapolis cumb to a bout of arsenic poisoning. Additional Veterans Administration Medical Center. This episodes occurred while he was away on pass from case was representative of the subsequent survey the hospital, with documented elevations of urine results in that Terro Ant Killer proved to be the arsenic levels on return to the hospital. With per­ source of arsenic. In addition, this case was par­ mission of the patient and his wife, the home was ticularly interesting because the patient was will­ thoroughly searched for arsenic, which resulted in fully self-administering arsenic for the purpose the discovery of a partially used bottle of Terro of creating and maintaining a state of chronic Ant Killer. The search also found medical texts invalidism. with underlined descriptions of arsenic poisoning. In addition, a sensationalized and annotated arti­ cle was found describing the arsenic poisoning Case Report of Clare Booth Luce while she was ambassador to A 57-year-old unemployed man was first admit­ Italy. Multiple artifacts and volumes relating to the ted to the Minneapolis VA Medical Center in April occult were also noted. 1977, with initial complaints and findings including Subsequent psychiatric and psychological eval­ severe abdominal cramping, diarrhea, and pan­ uations suggested that the patient was highly intel­ cytopenia. After the gastrointestinal complaints ligent, depressed, narcissistic, and hysteroid. He resolved, severe acroparesthesias and gait diffi­ revealed, after several years of interviews, his culty appeared. Serial examinations revealed pro­ conviction that he could communicate with his de­ gressively more peripheral neuropathy. Urine ceased mother through involuntary writing. The analysis for arsenic revealed a strikingly elevated patient reported that this psychical automatism of level (3,600 mg/L, normal value < .015 mg/L). Di- his hand also allowed communication with a num­ mercaprol treatment was begun. Efforts to deter­ ber of other deceased persons who would provide mine the source of the arsenic poisoning were in­ him with advice and counseling. Paranoid tenden­ conclusive. The patient denied any knowledge of cies were expressed. He was certain that he was exposure to arsenic. He stated that he was “ sepa­ being spied on through one-way mirrors and hid­ rated” from his wife, although they continued to den microphones. He was diagnosed as having occupy the same house, living on different floors. a narrowly confined delusional system that had 424 THE JOURNAL OF FAMILY PRACTICE, VOL. 17, NO. 3, 1983 ARSENIC POISONING escaped detection for years because of marked may occur. In the most severe form, urine reten­ defensiveness. tion, shock, and death are seen. He continued to express a strong desire to Chronic arsenic intoxication is manifested by clarify the circumstances surrounding his recur­ malaise and fatigue. Skin findings include in­ rent arsenic poisoning. An amobarbital (Amytal creased pigmentation and hyperkeratosis of the Sodium) interview was conducted in an attempt to palms and soles. Transverse white lines in the nail overcome the patient’s substantial resistance. beds (Mee's lines) appear approximately six Under Amytal he revealed that he had first ad­ weeks following intoxication. Peripheral neuropa­ ministered arsenic to himself in 1947. He had thy with prominent muscle atrophy is also a late proved to be an unsuccessful college teacher and finding in severe arsenic poisoning. Severe hema­ had attempted suicide by ingesting arsenic. The tological abnormalities including pancytopenia are poisoning had made him mildly ill and had given associated with arsenic intoxications.5 rise to some mild disturbance of his legs. To him A neurological finding that occurs earlier but this was sufficient to justify retirement in a face­ has received very little attention is an unusual saving way. He lived with his mother until her posturing of the hands. A waxy immobility of the death. Following his mother’s death, he married hands is brought about by intense dysesthesias in his mother’s best friend and continued in a simi­ the hands and feet. The painful sensory symptoms larly dependent relationship with his wife. and hand immobility are consistently seen in se­ During a routine visit to a Veterans Adminis­ vere arsenic poisoning. In addition to the sensory tration clinic, a well-intentioned house officer sug­ complaints, the hands and feet may be slightly ery­ gested vocational counseling and a return to work. thematous and edematous. Intense acrodysesthe- This suggestion, combined with the patient’s sias are not specific for arsenic poisoning, as they chronic feelings of inadequacy, resulted in emo­ may occasionally be seen in other disorders such tional turmoil. Subsequently, he began intermit­ as acute Guillain-Barre syndrome. tent self-administration of arsenic to maintain a Treatment of acute arsenic poisoning consists state of chronic invalidism. He also revealed while of fluid replacement during the initial gastrointesti­ under Amytal that he had a large supply of Terro nal illness. Dimercaprol remains the treatment Ant Killer hidden, and that he typically would mix of choice. This chelating agent has proved most it with beer to make it more palatable. Because of effective when administered within hours of the his expressed belief that he might well continue to
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