Synthesis of Aliphatic Bis(Thioureas)
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Determination of Thiamazole in Tablet Formulation by Using Reversed Phase Liquid Chromatographic Method
4th International Symposium on Innovative Approaches in Engineering and Natural Sciences SETSCI Conference November 22-24, 2019, Samsun, Turkey Proceedings https://doi.org/10.36287/setsci.4.6.146 4 (6), 512-515, 2019 2687-5527/ © 2019 The Authors. Published by SETSCI Determination of Thiamazole in Tablet Formulation by Using Reversed Phase Liquid Chromatographic Method Kader Poturcu1+, Ebru Çubuk Demiralay1* 1Arts & Science Faculty, Suleyman Demirel University, Isparta, Turkey *Corresponding author: [email protected] +Speaker: [email protected] Presentation/Paper Type: Oral / Full Paper Abstract – In this study, the amount of thiamazole (methimazole) in pharmaceutical tablet formulation was determined by using reversed phase liquid chromatography method (RPLC). Chromatographic separation was carried out by using YMC Triart C18 (150 mm × 4.6 mm, 3μm, YMC, USA) column. 5% (v/v) acetonitrile-water binary mixture at pH 9.5 was used as a mobile phase. Metronidazole was chosen as an internal standard. Flow rate was 0.8 ml/min and column temperature was 25 °C in chromatographic separation. The studied wavelengths for thiamazole and metronidazole are 260 and 340 nm, respectively. This proposed method was suitably validated with respect to accuracy, precision, linearity, the limit of detection (LOD) and limit of quantification (LOQ). The calibration graph of thiamazole was linear from 4 ppm to 14 ppm. The recovery of the 5 mg thiamazole containing commercial tablet (Thyromazol) was 100.059%. The proposed RPLC method was successfully applied to the determination of thiamazole in commercial tablet formulation. Keywords –Thiamazole, tablet formulation, RPLC method, method validation, recovery. I. INTRODUCTION In the last years thiamazole became also a fashioned model substance for endocrine disruption (thyroid axis) studies thus During the last decades, there has been increasing evidence inhibits the production of the thyroid hormones. -
Cool Reaction the Endothermic Reaction Between SCIENTIFIC Barium Hydroxide and Ammonium Thiocyanate
Cool Reaction The Endothermic Reaction Between SCIENTIFIC Barium Hydroxide and Ammonium Thiocyanate Introduction Many reactions produce heat, in fact when people think of chemical reactions, heat production is often expected. However, endothermic reactions, reactions which consume heat, can be just as exciting. One of the most striking examples of this is when the solids barium hydroxide and ammonium thiocyanate are mixed together in a beaker. Materials Ammonium thiocyanate, NH4SCN, 10 g Stirring rod Barium hydroxide octahydrate, Ba(OH)28H2O, 20 g Thermometer graduated to at least –30 °C Erlenmeyer flask, small, with stopper, or a 50-mL beaker Safety Precautions Barium salts are toxic by ingestion. Ammonium thiocyanate is also toxic by ingestion. Use caution when handling the beaker or flask. Use tongs if available. The temperatures involved are cold enough to freeze skin. Ammonia vapor is very irritating to eyes and the respiratory tract. Do not allow students to inhale this gas. Wear chemical splash goggles, chemical-resistant gloves, and a chemical-resistant apron. Please review current Material Safety Data Sheets for additional safety, handling, and disposal information. Procedure 1. Transfer 20 g of barium hydroxide and 10 g of ammonium thiocyanate to a flask and mix with a glass or plastic stirring rod. 2. In less than two minutes the solids become liquid. A thermometer placed in the mixture shows the temperature falling far below freezing. An ammonia odor is evident to all who are near the flask. 3. Place the flask in a small puddle of water and your students will clearly see just how cool this reaction is; the water will freeze the flask to the counter top. -
Gold Dissolution in Acid Thiourea-Thiocyanate Solutions Using Ferric As Oxidant
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by The University of Utah: J. Willard Marriott Digital Library University of Utah Institutional Repository Author Manuscript Thiourea-thiocyanate leaching system for gold a b b b a Xiyun Yang , Michael S. Moats , Jan D. Miller , Xuming Wang , Xichang Shi , a Hui Xu a UU IR Author Manuscript School of Metallurgical Science and Engineering, Central South University, Hunan 410083, China bDepartment of Metallurgical Engineering, College of Mines and Earth Sciences, University of Utah, Salt Lake City, Utah 84112, USA Abstract: The leaching of gold in thiourea-thiocyanate solutions has been studied by the rotating-disk technique using ferric sulfate as oxidant. The effects of initial concentrations of ferric, thiourea (Tu) and thiocyanate as well as temperature and pH values on gold leaching rates were studied. An initial gold leaching rate in the order of -9 -2 -1 10 mol cm s was obtained at 25℃, which was higher than rates obtained when either ferric-thiocyanate or ferric-thiourea solutions were used separately. The synergistic effect was attributed to the formation of a mixed ligand complex UU IR Au(Tu)2SCN. Determinations of apparent activation energy indicate that the process was controlled by a combination of chemical reaction and diffusion in the mixed lixiviant system. Open circuit potentials show that thiocyanate stability is increased in Author Manuscript the mixture. Keywords: Gold dissolution; Thiourea; Thiocyanate; Synergistic effect 1. Introduction Corresponding author:Tel.:+86 731 88877352; fax:+86 731 88710171 E-mail address:[email protected](Xiyun Yang) University of Utah Institutional Repository Author Manuscript A possible alternative reagent to cyanide for gold leaching is thiocyanate, as first reported by White (1905). -
Thyroid Hormone Regulation of Mrnas Encoding Thyrotropin β-Subunit, Glycoprotein Î
Thyroid hormone regulation of mRNAs encoding thyrotropin b-subunit, glycoprotein a-subunit, and thyroid hormone receptors a and b in brain, pituitary gland, liver, and gonads of an adult teleost, Pimephales promelas Sean C Lema, Jon T Dickey , Irvin R Schultz and Penny Swanson Abstract Thyroid hormones (THs) regulate growth, morphological transcript levels for TR isoforms a and b (tra and trb) in the development, and migratory behaviors in teleost fish, yet liver and brain, but reduced levels of brain mRNA for the little is known about the transcriptional dynamics of gene immediate-early gene basic transcription factor-binding targets for THs in these taxa. Here, we characterized TH protein (bteb). In the ovary and testis, exogenous T3 elevated regulation of mRNAs encoding thyrotropin subunits and gene transcripts for tshb, glycoprotein hormone a-subunit thyroid hormone receptors (TRs) in an adult teleost fish ( gpha), and trb, while not affecting tra levels. Taken model, the fathead minnow (Pimephales promelas). Breeding together, these results demonstrate negative feedback of T4 pairs of adult minnows were fed diets containing 3,5, on pituitary tshb, identify tra and trb as T3-autoinduced 0 3 -triiodo-L-thyronine (T3) or the goitrogen methimazole genes in the brain and liver, and provide new evidence for 10 days. In males and females, dietary intake of that tshb, gpha, and trb are THs regulated in the gonad of exogenous T3 elevated circulating total T3, while methima teleosts. Adult teleost models are increasingly used to zole depressed plasma levels of total thyroxine (T4). In both evaluate the endocrine-disrupting effects of chemical sexes, this methimazole-induced reduction in T4 led to contaminants, and our results provide a systemic assessment elevated mRNA abundance for thyrotropin b-subunit (tshb) of TH-responsive genes during that life stage. -
1 Abietic Acid R Abrasive Silica for Polishing DR Acenaphthene M (LC
1 abietic acid R abrasive silica for polishing DR acenaphthene M (LC) acenaphthene quinone R acenaphthylene R acetal (see 1,1-diethoxyethane) acetaldehyde M (FC) acetaldehyde-d (CH3CDO) R acetaldehyde dimethyl acetal CH acetaldoxime R acetamide M (LC) acetamidinium chloride R acetamidoacrylic acid 2- NB acetamidobenzaldehyde p- R acetamidobenzenesulfonyl chloride 4- R acetamidodeoxythioglucopyranose triacetate 2- -2- -1- -β-D- 3,4,6- AB acetamidomethylthiazole 2- -4- PB acetanilide M (LC) acetazolamide R acetdimethylamide see dimethylacetamide, N,N- acethydrazide R acetic acid M (solv) acetic anhydride M (FC) acetmethylamide see methylacetamide, N- acetoacetamide R acetoacetanilide R acetoacetic acid, lithium salt R acetobromoglucose -α-D- NB acetohydroxamic acid R acetoin R acetol (hydroxyacetone) R acetonaphthalide (α)R acetone M (solv) acetone ,A.R. M (solv) acetone-d6 RM acetone cyanohydrin R acetonedicarboxylic acid ,dimethyl ester R acetonedicarboxylic acid -1,3- R acetone dimethyl acetal see dimethoxypropane 2,2- acetonitrile M (solv) acetonitrile-d3 RM acetonylacetone see hexanedione 2,5- acetonylbenzylhydroxycoumarin (3-(α- -4- R acetophenone M (LC) acetophenone oxime R acetophenone trimethylsilyl enol ether see phenyltrimethylsilyl... acetoxyacetone (oxopropyl acetate 2-) R acetoxybenzoic acid 4- DS acetoxynaphthoic acid 6- -2- R 2 acetylacetaldehyde dimethylacetal R acetylacetone (pentanedione -2,4-) M (C) acetylbenzonitrile p- R acetylbiphenyl 4- see phenylacetophenone, p- acetyl bromide M (FC) acetylbromothiophene 2- -5- -
United States Patent to 11 4,012,839 Hill 45 Mar
United States Patent to 11 4,012,839 Hill 45 Mar. 22, 1977 (54) METHOD AND COMPOSITION FOR TREATING TEETH OTHER PUBLICATIONS 75) Inventor: William H. Hill, St. Paul, Minn. Dental Abstracts, "Silver Nitrate Treatment of Proxi (73) Assignee: Peter Strong & Company, Inc., mal Caries in Primary Molars', p. 272, May 1957. Portchester, N.Y. Primary Examiner-Robert Peshock (22 Filed: Nov. 26, 1973 Attorney, Agent, or Firm-Thomas M. Meshbesher (21) Appl. No.: 418,997 57 ABSTRACT 52 U.S. Cl. ................................... 32/15; 424/129; In the well-known technique of disinfecting caries 424/210 infected or potentially caries-infected dental tissue with 51 int. Cl”.......................................... A61K 5/02 silver nitrate, silver thiocyanate or its complexes have 58 Field of Search ............ 424/290, 132, 129, 49, been substituted for silver nitrate with excellent disin 424/54; 32/15 fecting results and lowered side effects, e.g., with low 56) References Cited ered toxicity toward dental tissues and mouth mem UNITED STATES PATENTS branes and less blackening of exposed portions of the teeth. 1,740,543 12/1929 Gerngross .......................... 424/129 2,981,640 4/1961 Hill ................................. 171138.5 3,421,222 1/1969 Newman ................................ 32/15 16 Claims, No Drawings 4,012,839 1 2 and potassium or barium thiocyanate as a relatively METHOD AND COMPOSITION FOR TREATING non-irritating disinfectant is disclosed. TEETH Silver thiocyanate (AgSCN) is known to be both bactericidal and relatively light stable; see U.S. Pat. No. FIELD OF THE INVENTION 2,981,640 (Hill), issued Apr. 25, 1961. The Hill patent This invention relates to a method for treating mam teaches the use of AgSCN or mixtures thereof with malian dental tissue with a bactericidal amount of a other thiocyanates to treat or sterilize cloth articles silver salt. -
Heats of Formation of Certain Nickel-Pyridine Complex Salts
HEATS OF FORFATION OF CERTAIN NICKEL-PYRIDINE COLPLEX SALTS DAVID CLAIR BUSH A THESIS submitted to OREGON STATE COLLEGE in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE June l9O [4CKNOWLEDGMENT The writer wishes to acknowledge his indebtedness and gratitude to Dr. [4. V. Logan for his help and encour- agement during this investigation. The writer also wishes to express his appreciation to Dr. E. C. Gilbert for helpful suggestions on the con- struction of the calortheter, and to Lee F. Tiller for his excellent drafting and photostating of the figures and graphs. APPROVED: In Charge of ?ajor Head of Department of Chemistry Chairrian of School Graduate Comrittee Dean of Graduate School Date thesis is presented /11 ' Typed by Norma Bush TABLE OF CONTENTS HISTORICAL BACKGROUND i INTRODUCTION 2 EXPERIMENTAL 5 Preparation of the Compounds 5 Analyses of the Compounds 7 The Calorimeter Determination of the Heat Capacity 19 Determination of the Heat of Formation 22 DISCUSSION 39 41 LITERATURE CITED 42 TABLES I Analyses of the Compounds 8 II Heat Capacity of the Calorimeter 23 III Heat of Reaction of Pyridine 26 IV Sample Run and Calculation 27 V Heat of Reaction of Nickel Cyanate 30 VI Heat of Reaction of Nickel Thiocyanate 31 VII Heat of Reaction of Hexapyridinated Nickel Cyanate 32 VIII Heat of Reaction of Tetrapyridinated Nickel Thiocyanate 33 IX Heat of Formation of the Pyridine Complexes 34 FI GURES i The Calorimeter 10 2 Sample Ijector (solids) 14 2A Sample Ejector (liquids) 15 3 Heater Circuit Wiring Diagram 17 4 heat Capacity of the Calorimeter 24 5 Heat of Reaction of Pyridine 28 6 Heat of Reaction of Hexapyridinated Nickel Cyanate 35 7 Heat of Reaction of Tetrapyridinated Nickel Thiocyanate 36 8 Heat of Reaction of Nickel Cyanate 37 9 Heat of Reaction of Nickel Thiocyanate 38 HEATS OF FOW ATION OF CERTAIN NICKEL-PYRIDINE COMPLEX SALTS HISTORICAL BACKGROUND Compounds of pyridine with inorganic salts have been prepared since 1970. -
United States Patent Office Patented Jan
3,071,593 United States Patent Office Patented Jan. 1, 1963 2 3,071,593 O PREPARATION OF AELKENE SULFES Paul F. Warner, Philips, Tex., assignor to Philips Petroleum Company, a corporation of Delaware wherein each R is selected from the group consisting of No Drawing. Filed July 27, 1959, Ser. No. 829,518 5 hydrogen, alkyl, aryl, alkaryl, aralkyl and cycloalkyl 8 Claims. (C. 260-327) groups having 1 to 8 carbon atoms, the combined R groups having up to 12 carbon atoms. Examples of Suit This invention relates to a method of preparing alkene able compounds are ethylene oxide, propylene oxide, iso sulfides. Another aspect relates to a method of convert butylene oxide, a-amylene oxide, styrene oxide, isopropyl ing an alkene oxide to the corresponding sulfide at rela O ethylene oxide, methylethylethylene oxide, 3-phenyl-1, tively high yields without refrigeration. 2-propylene oxide, (3-methylphenyl) ethylene oxide, By the term "alkene sulfide' as used in this specifica cyclohexylethylene oxide, 1-phenyl-3,4-epoxyhexane, and tion and in the claims, I mean to include not only un the like. substituted alkene sulfides such as ethylene sulfide, propyl The salts of thiocyanic acid which I prefer to use are ene sulfide, isobutylene sulfide, and the like, but also 5 the salts of the alkali metals or ammonium. I especially hydrocarbon-substituted alkene sulfides such as styrene prefer ammonium thiocyanate, sodium thiocyanate, and oxide, and in general all compounds conforming to the potassium thiocyanate. These compounds can be reacted formula with ethylene oxide in a cycloparaffin diluent to produce 20 substantial yields of ethylene sulfide and with little or S no polymer formation. -
Ammonium Thiocyanate Amt
AMMONIUM THIOCYANATE AMT CAUTIONARY RESPONSE INFORMATION 4. FIRE HAZARDS 7. SHIPPING INFORMATION 4.1 Flash Point: 7.1 Grades of Purity: Reagent; Technical, 50-65% Common Synonyms Solid or solution (in White Odorless Solid may be combustible; solution is not solution in water water) Ammonium rhodanate flammable. 7.2 Storage Temperature: Ambient Ammonium rhodanide 4.2 Flammable Limits in Air: Not pertinent Ammonium sulfocyanate 7.3 Inert Atmosphere: No requirement 4.3 Fire Extinguishing Agents: Water Ammonium sulfocyanide Sinks and mixes with water. 7.4 Venting: Open Thiocyanic acid, ammonium salt 4.4 Fire Extinguishing Agents Not to Be Used: Currently not available 7.5 IMO Pollution Category: Currently not available 7.6 Ship Type: Currently not available Stop discharge if possible. Keep people away. 4.5 Special Hazards of Combustion Call fire department. Products: Decomposes to form 7.7 Barge Hull Type: Currently not available Avoid contact with liquid and solid. ammonia, hydrogen sulfide, and hydrogen cyanide. Oxides of nitrogen Avoid contact with solid and dust. 8. HAZARD CLASSIFICATIONS Isolate and remove discharged material. may also form. All of these products are Notify local health and pollution control agencies. toxic. 8.1 49 CFR Category: Not listed Protect water intakes. 4.6 Behavior in Fire: Currently not available 8.2 49 CFR Class: Not pertinent 4.7 Auto Ignition Temperature: Not pertinent 8.3 49 CFR Package Group: Not listed. Combustible Solid. Solution not flammable. 4.8 Electrical Hazards: Not pertinent Fire POISONOUS GASES MAY BE PRODUCED IN FIRE. 8.4 Marine Pollutant: No Wear goggles and self-contained breathing apparatus. -
TR-332: 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6c3f1mice (Gavage Studies)
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 332 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2-MERCAPTOBENZOTHIAZOLE (CAS NO. 149-30-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health NATIONAL TOXICOLOGY PROGRAM The National Toxicology Program (NTP), established in 1978,develops and evaluates scientific information about potentially toxic and hazardous chemicals. This knowledge can be used for protecting the health of the American people and for the primary prevention of disease. By bringing to- gether the relevant programs, staff, and resources from the US. Public Health Service, DHHS, the National Toxicology Program has centralized and strengthened activities relating to toxicology research, testing and test developmenthalidation efforts, and the dissemination of toxicological in- formation to the public and scientific communities and to the research and regulatory agencies. The NTP is made up of four charter DHHS agencies: the National Cancer Institute (NCI), National Institutes of Health; the National Institute of En- vironmental Health Sciences (NIEHS), National Institutes of Health; the National Center for Toxicological Research (NCTR), Food and Drug Ad- ministration; and the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control. In July 1981, the Carcino- genesis Bioassay Testing Program, NCI, was transferred to the NIEHS. 2-Mercaptobenzothiazole,NTP TR 332 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2-MERCAPTOBENZOTHIAZOLE (CAS NO. 149-30-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) Michael P. Dieter, Ph.D., Chemical Manager NATIONAL TOXICOLOGY PROGRAM P.O. Box S2233 Research Triangle Park, NC 27709 May 1988 NTP TR 332 NIH Publication No. -
House Fly Attractants and Arrestante: Screening of Chemicals Possessing Cyanide, Thiocyanate, Or Isothiocyanate Radicals
House Fly Attractants and Arrestante: Screening of Chemicals Possessing Cyanide, Thiocyanate, or Isothiocyanate Radicals Agriculture Handbook No. 403 Agricultural Research Service UNITED STATES DEPARTMENT OF AGRICULTURE Contents Page Methods 1 Results and discussion 3 Thiocyanic acid esters 8 Straight-chain nitriles 10 Propionitrile derivatives 10 Conclusions 24 Summary 25 Literature cited 26 This publication reports research involving pesticides. It does not contain recommendations for their use, nor does it imply that the uses discussed here have been registered. All uses of pesticides must be registered by appropriate State and Federal agencies before they can be recommended. CAUTION: Pesticides can be injurious to humans, domestic animals, desirable plants, and fish or other wildlife—if they are not handled or applied properly. Use all pesticides selectively and carefully. Follow recommended practices for the disposal of surplus pesticides and pesticide containers. ¿/áepé4áaUÁí^a¡eé —' ■ -"" TMK LABIL Mention of a proprietary product in this publication does not constitute a guarantee or warranty by the U.S. Department of Agriculture over other products not mentioned. Washington, D.C. Issued July 1971 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 - Price 25 cents House Fly Attractants and Arrestants: Screening of Chemicals Possessing Cyanide, Thiocyanate, or Isothiocyanate Radicals BY M. S. MAYER, Entomology Research Division, Agricultural Research Service ^ Few chemicals possessing cyanide (-CN), thio- cyanate was slightly attractive to Musca domes- eyanate (-SCN), or isothiocyanate (~NCS) radi- tica, but it was considered to be one of the better cals have been tested as attractants for the house repellents for Phormia regina (Meigen). -
Material Safety Data Sheet
Material Safety Data Sheet Silver Thiocyanate (Powder), 99% (Titr.) ACC# 55179 Section 1 - Chemical Product and Company Identification MSDS Name: Silver Thiocyanate (Powder), 99% (Titr.) Catalog Numbers: AC419390000, AC419390250 Synonyms: None. Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 For information in North America, call: 800-ACROS-01 For emergencies in the US, call CHEMTREC: 800-424-9300 Section 2 - Composition, Information on Ingredients CAS# Chemical Name Percent EINECS/ELINCS 1701-93-5 Thiocyanic Acid, Silver(1+) Salt 99 216-934-9 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: white powder. Caution! May cause eye and skin irritation. May cause respiratory and digestive tract irritation. Light sensitive. Moisture sensitive. The toxicological properties of this material have not been fully investigated. Target Organs: None known. Potential Health Effects Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Ingestion of soluble silver salts may cause argyria, characterized by permanent blue-gray pigmentation of the skin, mucous membranes, and eyes. Ingestion of silver compounds may cause abdominal pain, rigidity, convulsions and shock. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.