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Symposium Programme PHEASANT RUN ST. CHARLES, IL L I N O I S U S A JULY 7 - 11, 2009 Website: http://www.cannabinoidsociety.org Symposium Programming by Cortical Systematics LLC Copyright © 2009 International Cannabinoid Research Society, Inc. Department of Psychology University of Vermont Burlington VT 05405 USA ISBN: 0-9786040-3-2 These abstracts may be cited in the scientific literature. The citation format is as follows: Author(s), Abstract Title (2009) 19th Annual Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, Page #. The 2009 ICRS Symposium on the Cannabinoids is dedicated to the memory of Dr. Christopher S. Kearn Didier M. Lambert, Coco N. Kapanda, BIS[(DIALKYLTHIOCARBAMOYL)]DISULFIDE Giulio G. Muccioli, DERIVATIVES AS POTENT AND SELECTIVE Geoffray Labar MONOGLYCERIDE LIPASE INHIBITORS and Jacques H. Poupaert John W. Huffman, STRUCTURE-ACTIVITY RELATIONSHIPS Valerie J. Smith, AT THE CB1 AND CB2 RECEPTORS FOR Jianhong Chen, 1-ALKYL-3-(1-NAPHTHOYL-4 Jenny L. Wiley AND 8-HALOGEN SUBSTITUTED) INDOLES and Billy R. Martin Xiang-Qun (Sean) Xie, Yuxun Zhang, Lirong DISCOVERY OF NEW CB2 LIGANDS Wang, Jianzhong Chen, WITH NOVEL CHEMICAL SCAFFOLD Juerg Gertsch and Dana E. Selley Michael Meyer, Betty Yao, Anthony Daza, Yihong Fan, A-1036654, A NOVEL ORALLY Lanlan Li, Loan Miller, BIOAVAILABLE CB2-SELECTIVE AGONIST Odile El Kouhen, Gin EXHIBITING ANALGESIC ACTIVITY IN Hsieh, Erica Wensink, Anita RODENT MODELS OF OSTEOARTHRITIC Salyers, Prasant Chandran, AND NEUROPATHIC PAIN Michael Dart, Tongmei Li and William Carroll Aron H. Lichtman, Anu Mahadevan, Raj K. Razdan, COMPARISON BETWEEN THE CB2 RECEPTOR AGONIST O-3223 AND THE Sreenivasulu P. Naidu, POTENT, MIXED CB1/CB2 RECEPTOR Steven G. Kinsey, AGONIST CP55,940 IN A BATTERY OF Bingjun Zhao, Hang Sun, NOCICEPTIVE ASSAYS Dana E. Selley and M. Imad Damaj Jenny L. Wiley, Pinglang Wang, PYRAZOLE CANNABINOIDS WITH Anu Mahadevan, NON-CB1, NON-CB2 ACTIVITY Raj K. Razdan and Billy R. Martin Zhuanhong Qiao, DETERMINATION OF AN INTERNAL Jian Cai, DISULFIDE BOND IN THE SECOND William M. Pierce Jr. EXTRACELLULAR LOOP OF CANNABINOID and Zhao-Hui Song CB2 RECEPTOR BY MASS SPECTROMETRY Mitzi Nagarkatti, TARGETING CANNABINOID RECEPTORS Rupal Pandey AS A NOVEL APPROACH TO PREVENT and Prakash Nagarkatti GRAFT-VERSUS-HOST DISEASE Orr Ofek, Malka Attar-Namdar, OSTEOBLASTIC CB2 CANNABINOID Esther Shohami, RECEPTOR ACTIVATES GI PROTEIN-ERK1/2- Raphael Mechoulam MAPKAPK2 -CREB SIGNALING PATHWAY and Itai Bab Nancy E. Buckley, DELTA-9-TETRAHYDROCANNABINOL, Beverly McDowell, CB2R AND IMMUNITY TO YEAST Ehsan Taqavi INFECTION and Gideon Blumstein Betty B Yao, Odile El Kouhen, Gin Hsieh, Yihong Fan, Bradley A Hooker, Loan Miller, David G Witte, Lanlan Li, CB2 RECEPTOR-MEDIATED ANTI- Steve McGaraughty, ALLODYNIC EFFECTS IN NEUROPATHIC Kathleen Chu, PAIN MODELS IS LIKELY MEDIATED Madhavi Pai, Erica J THROUGH NON-NEURONAL CELLS Wensink, Anita K Salyers, Chang Z Zhu, William A Carroll, Michael J Dart and Michael D Meyer Kofi-Kermit Horton, Sarah Bough, CHRONIC RIMONABANT ALTERS Anushka Goonawardena, BEHAVIOR AND GENE EXPRESSION IN John Sesay, HIPPOCAMPUS DURING LEARNING Allyn Howlett and Robert E. Hampson Peter Nguyen, Cullen L. Schmid, Kirsten M. BETA-ARRESTIN 2 REGULATES CB1 RECEPTOR DESENSITIZATION Raehal, Dana E. Selley, AND THC-MEDIATED Laura M. Bohn ANTINOCICEPTIVE TOLERANCE and Laura J. Sim-Selley DIFFERENTIAL REGULATION OF DSI TIME Alex Straiker COURSE IN IDENTIFIED POPULATIONS OF and Ken Mackie AUTAPTIC HIPPOCAMPAL NEURONS EXPRESSION, LOCALIZATION, AND DRUG MODULATION OF CANNABINOID CB1 AND Val J. Watts DOPAMINE D2 RECEPTOR HETERODIMERS and Julie A. Przybyla IN CATH.A DIFFERENTIATED NEURONAL CELLS Joel E. Schlosburg, James J. Burston, Steven G. Kinsey, BEHAVIORAL AND FUNCTIONAL Lamont Booker, ADAPTATION OF THE ENDOCANNABINOID Rehab A. Abdullah, SYSTEM FOLLOWING REPEATED Jonathan Z. Long, MONOACYLGLYCEROL LIPASE Dana E. Selley, (MAGL) INHIBITION Benjamin F. Cravatt and Aron H. Lichtman LONG-TERM DEPRESSION IN VENTRAL TEGMENTAL DOPAMINE NEURONS Xia Zhang MEDIATES LEARNING TO ASSOCIATE CANNABINOID EXPOSURE WITH ENVIRONMENTAL CUES Sachin Patel, REPEATED HOMOTYPIC STRESS ELEVATES Philip J. Kingsley, 2-AG AND ENHANCES DEPOLARIZATION- Ken Mackie, INDUCED SUPRESSION OF INHIBITION IN Lawrence J. Marnett BASOLATERAL AMYGDALA and Danny G. Winder Tiziana Rubino, Natalia Realini, URB597 RECOVERS SOME OF THE SIGNS PRESENT IN THE DEPRESSIVE Daniela Vigano’, PHENOTYPE INDUCED BY Guidali Cinzia ADOLESCENT EXPOSURE TO THC and Daniela Parolaro “THE GLUTAMATE HOMEOSTASIS HYPOTHESIS OF ADDICTION” Medical University of South Carolina Chris Henstridge, LACK OF SPECIFICITY FOR CANNABINOID CB1 RECEPTOR Simon Arthur ANTAGONISTS: INTERACTIONS and Andrew Irving WITH GPR55 Khalil Eldeeb, LPI-EVOKED INCREASES IN Stephen Alexander, INTRACELLULAR CALCIUM David Pritchard INCREASES IN MICROGLIAL and David Kendall CELLS IN CULTURE Ankur Kapur, Pingwei Zhao, Haleli Sharir, Yushi Bai, GPR55: TO BE OR NOT TO BE A Marc G. Caron, Larry S. Barak CANNABINOID RECEPTOR and Mary E. Abood Nariman Balenga, Ralf Schröder, FUNCTIONAL SELECTIVITY OF Wolfgang Platzer, Julia Kargl, CANNABINOIDS ON THE NOVEL Christopher M Henstridge, CANNABINOID RECEPTOR GPR55 Andrew J Irving, Evi Kostenis and Maria Waldhoer LYSOPHOSPHATIDYLINOSITOL INDUCES RAPID CYTOSKELETAL REARRANGEMENTS AND Takayuki Sugiura, MORPHOLOGICAL CHANGES IN Atsushi Yamashita HEK293 CELLS EXPRESSING and Saori Oka GPR55: FURTHER EVIDENCE THAT LYSOPHOSPHATIDYL- INOSITOL IS THE NATURAL LIGAND FOR GPR55 Lisa A.Gauson, CANNABIGEROL DISPLAYS Maria-Grazia Cascio, SIGNIFICANT POTENCY Ruth A. Ross AS A 5-HT1A RECEPTOR and Roger G. Pertwee ANTAGONIST Sean D. McAllister, Darryl Lau, Rigel T. Christian, Arash E. CANNABIDIOL AS A NOVEL INHIBITOR OF ID-1 GENE Pakdel, Anne J. Zielinski, EXPRESSION IN AGGRESSIVE Jasmine Lee, Dan H. Moore BREAST CANCER CELLS and Pierre-Yves Desprez Nicholas A. Jones, ANTICONVULSANT EFFECTS OF CANNABIDIOL UPON Andrew J. Hill, Gary J. Stephens, SPONTANEOUS EPILEPTIFORM Claire M. Williams ACTIVITY IN ACUTE and Benjamin J. Whalley HIPPOCAMPAL BRAIN SLICES Tamás Bíró, Attila Oláh, CANNABIDIOL AS A NOVEL Balázs I. Tóth, ANTI-ACNE AGENT? CANNABIDIOL INHIBITS LIPID Gabriella Czifra, SYNTHESIS AND INDUCES CELL Christos C. Zouboulis DEATH IN HUMAN SEBACEOUS and Ralf Paus GLAND-DERIVED SEBOCYTES CANNABIDIOL (THE NON- Erin M. Rock, PSYCHOACTIVE COMPONENT OF Cheryl L. Limebeer, CANNABIS) MAY ACT AS A 5- Raphael Mechoulam HT1A AUTO-RECEPTOR AGONIST and Linda A. Parker TO REDUCE TOXIN-INDUCED NAUSEA AND VOMITING Daniele De Filippis, Giuseppe Esposito, CANNABIDIOL CONTROLS INTESTINAL INFLAMMATION Mariateresa Ciprian, THROUGH THE MODULATION OF Caterina Scuderi, Joris De Man ENTERIC GLIAL CELLS and Teresa Iuvone INDIVIDUAL DIFFERENCES IN RESPONSES TO DRUGS IN HUMANS University of Chicago GABAA MODULATION OF THE Joshua A. Lile, Thomas H. Kelly DISCRIMINATIVE STIMULUS and Lon R. Hays EFFECTS OF 9-THC IN HUMANS CANNABIS AS A SUBSTITUTE FOR Amanda Reiman ALCOHOL AND OTHER DRUGS Andrea M Dlugos, Ajna Hamidovic, MORE AROUSED, LESS FATIGUED: Colin A Hodgkinson, FAAH GENE POLYMORPHISMS David Goldman, INFLUENCE ACUTE RESPONSE Abraham A Palmer TO AMPHETAMINE and Harriet de Wit José Alexandre S. Crippa, Guilherme Nogueira Derenusson, Thiago Borduqui Ferrari, Lauro Wichert-Ana, Fábio Duran, Rocio Martin- Santos, Marcus Vinícius Simões, NEURAL BASIS OF ANXIOLYTIC EFFECTS OF CANNABIDIOL (CBD) Sagnik Bhattacharyya, Paolo IN GENERALIZED SOCIAL Fusar-Poli, Alaor Santos Filho, ANXIETY DISORDER Maria Cecília Freitas-Ferrari, Philip K. McGuire, Antonio Waldo Zuardi, Geraldo Busatto Filho, Jaime Eduardo Cecílio Hallak and Richard E. Musty SEX AND CANNABINOID CB1 GENOTYPE DIFFERENTIATE Sara Jane Ward PALATABLE FOOD AND COCAINE and Ellen A. Walker SELF-ADMINISTRATION IN MICE THE EFFECT OF CANNABIDIOL Daniel Thomas Malone, AND Dennis Jongegan 9-TETRAHYDROCANNABINOL and David Alan Taylor ON SOCIAL INTERACTION OF RATS GENETIC BASIS OF Emmanuel Shan Onaivi MARIJUANA USE Mark Ware, CANNABIS FOR THE Tongtong Wang, MANAGEMENT OF PAIN: Stan Shapiro ASSESSMENT OF SAFETY STUDY and Jean-Paul Collet (COMPASS) Notes: Lourdes Ruiz-Valdepeñas, CANNABIDIOL REDUCES José Antonio Martínez Orgado, LIPOPOLYSACCHARIDE-INDUCED Cristina Otalora, Marta Moreno, VASCULAR DYSFUNCTION IN África Millán, Rosa María Tolón THE MOUSE BRAIN: AN and Julián Romero INTRAVITAL MICROSCOPY STUDY Stefania Petrosino, Marcello Naccarato, BLOOD ENDOCANNABINOID AND Daniela Pizzuti, PALMITOYLETHANOLAMIDE Marco Simonetto, Fabio Chiodo LEVELS IN HUMAN ISCHEMIC Grandi, Gilberto Pizzolato STROKE and Vincenzo Di Marzo THE COMBINATION TREATMENT Ming Zhang, Martin W. Adler, WITH A CB2 AGONIST AND CB1 ANTAGONIST ATTENUATED Mary Abood, Doina Ganea CEREBRAL ISCHEMIC INJURY and Ronald F. Tuma THROUGH DIFFERENT MECHANISMS Yosefa Avraham, Nicholaos C Grigoriadis, CAPSAICIN AFFECTS BRAIN Iddo Magena, FUNCTION IN A MODEL OF Theofilos Poutahidis, HEPATIC ENCEPHALOPATHY Lia Vorobiava, Yaron Ilan, ASSOCIATED WITH FULMINANT Raphael Mechoulam HEPATIC FAILURE IN MICE and Elliot M Berry Somnath Mukhopadhyay, ENDOCANNABINOID AND CB1 RECEPTOR-MEDIATED Ju-Ahng Lee REGULATION OF NEUROGENESIS and Shailendra Devkota IN ZEBRAFISH Geoffray Labar, Franck Borel, MOLECULAR INSIGHT INTO Cédric Bauvois, Jean-Luc Ferrer, MONOGLYCERIDE LIPASE, THE Johan Wouters ENZYME DEGRADATING and Didier M. Lambert 2-ARACHIDONOYLGLYCEROL MECHANISTIC Jonathan Z. Long, CHARACTERIZATION OF SELECTIVE MONOACYLGLYCEROL LIPASE Daniel K. Nomura INHIBITION REVEALS DIFFERENCES and Benjamin
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