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Symposium Guide 2006

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Symposium Guide 2006 2006 Summer Student Research Symposium August 10, 2006 Program Guide The National Institutes of Health Short Term Training for Minority College Students Grant #5 T35 HL07807 NHLBI Comprehensive Sickle Cell Center Training of High School Students in Sickle Cell Disease Research Grant #1 P60 MD000222 2006 CHORI Summer Research Program Research 2006 CHORI Summer August 10, 2006 This summer was the 17h year that we offered a research internship program for high school and undergraduate students. Once again, we had an exceptional class of students working in the clinical (7) and laboratory (20) research settings. As can be seen from the personal statements and research abstracts, the contribution and experience gained by each participant is remarkable. Students came from a broad range of backgrounds and experiences. All were provided unique research programs, coordinated with mentors willing to teach and accommodate their student. We are most grateful for the support we received for summer student stipends from the NHLBI, as part of a Short Term Summer Minority Training Program, as well as from the Summer for Sickle Cell Training Program. Additionally, twelve volunteers conducted both clinical and laboratory research. All of the students participating in our program are presenting the results of their research in either an oral or poster presentation. Without the 42 mentors who dedicated time to teach these students the excitement and pleasure of working in basic, translational, or clinical research, the program would not succeed. In addition, staff who took the time to make the lecture series informative and engaging were outstanding. Barbara Staggers, Vasanthy Narayanaswami, Diane Kohlman and Phillip Bollinger are to be particularly acknowledged for their administrative assistance and for guiding students as required. Again, congratulations and thanks to all members of the CHORI/CHRCO family for making the Summer Student Research Internship program a success in 2006. Bertram H. Lubin, MD President, CHORI Director of Medical Research Children’s Hospital & Research Center at Oakland Director: Betram H. Lubin, M.D. President & Director of Medical Research at CHORI Co-Director: Co-Director: Barbara Staggers, M.D. Vasanthy Narayanaswami, Ph.D. Director, Adolescent Medicine Assistant Scientist at CHORI MENTORS Bruce Ames, Ph.D. Gregory Moe, Ph.D. Peter Beernink, Ph.D. Claudia Morris, M.D. Jeremy Brown, Ph.D. Vasanthy Narayanaswami, Ph.D. Susan Conrad, M.D. Janelle Noble, Ph.D. Kitty de Jong, Ph.D. Michael Oda, Ph.D. Pieter de Jong, Ph.D. Zahra Pakbaz, M.D. Deborah Dean, M.D., M.P.H. Donald Reason, Ph.D. David Durand, M.D. Robert Ryan, Ph.D. Catherine Egli, M.D. Julie Saba, M.D., Ph.D. Heidi Flori, M.D. Mark Shigenaga, Ph.D. Horst Fischer, Ph.D. Stuart Smith, Ph.D., D.Sc. Paul Harmatz, M.D. Barbara Staggers, M.D. Beate Illek, Ph.D. Jung Suh, Ph.D. David Iovannisci, Ph.D. Yuen Yee Tam, Ph.D. Lourdes Juarez, P.N.P. Shiori Tamamizu-Kato, Ph.D. David Killilea, Ph.D. Elizabeth Trachtenberg, Ph.D. Janet King, Ph.D. Marsha Treadwell, M.D. Frans Kuypers, Ph.D. Fernando Viteri, Ph.D., M.D. Ash Lal, M.D. Patsy Wakimoto, Ph.D. Edward Lammer, M.D. Gordon Watson, Ph.D. David Martin, M.D. Jo Anne Welsch, Ph.D. Olga Martinez Andrzej Witkowski, Ph.D. SELECTION COMMITTEE Bertram Lubin, M.D. Frans Kuypers, Ph.D. Barbara Staggers, M.D. Tomas Magana, M.D. Vasanthy Narayanaswami, Ph.D. John Matsui, Ph.D. Caroline Kane, Ph.D. Laurie Schumacher, M.D. PROGRAM ADMINISTRATION Bertram Lubin, M.D. Phillip Bollinger Barbara Staggers, M.D. Diane Kohlman Vasanthy Narayanaswami, Ph.D. 006 SCHEDULE OF STUDENT SEMINARS The lectures will be held in the Little Theater at CHORI at 4:00 pm Tuesday, June 7 Elizabeth Trachtenberg, PhD, d(ABHI) “The Role of HLA and KIR Complexes in Disease” Tuesday, July 11 Marsha Treadwell, PhD “Sickle Cell Disease” Tuesday, July 18 Elizabeth Jameson “Multiple Sclerosis” Tuesday, August 1 at 1:00 Noon Patty Siri, PhD “Dietary and Pharmacological Interventions in the Management of Lipid Abnormalities” Tuesday, August 8 Lydia Tinajero-Deck, MD “Obesity” SYMPOSIUM SCHEDULE 006 Summer Student Research Symposium Thursday, August 10, 006 CHORI Theater 8:30 – 9:00 Check-in and Continental Breakfast 9:00 – 9:15 Introduction by Program Directors Bertram H. Lubin, M.D. – Director Barbara Staggers, M.D. – Co-Director Vasanthy Narayanaswami, Ph.D. – Co-Director Oral Presentations Session 1 Troy Skwor, Ph.D., Postdoctoral Fellow Chairs: Grace Liu, Albany High School 9:15 – 9:30 Obi Amajoyi, University of California, Berkeley 17 Mentor: Lourdes Juarez, PNP Clinical Significance of Acanthosis Nigricans as a Phenotypic Marker for Type-2 Diabetes in Obese Adolescents 9:30 – 9:45 Richard Tibbs, Fisk University 7 Mentors: Claudia Morris, M.D., Paul Harmatz, M.D. Analyzing the Effects of Human Recombinant N- acetylgalactoamine on the Heart in Persons with Mucopolysaccharidosis VI 9:45 – 10:00 Laila Williams, Oberlin College 8 Mentors: Peter Beernink, Ph.D., Jo Anne Welsch, Ph.D., Dan Granoff, M.D. Sequence Analysis and Expression of Neisseria meningitidis Vaccine Candidates Factor H Binding Protein and NadA in Disease-Causing Group B Isolates From the United States 10:00 – 10:15 Daniel Hausrath, Head Royce School 9 Mentors: Lucia Carbone, Ph.D. Pieter de Jong, Ph.D. Examining Breakpoint Regions in the Family Hylobatidae 6 10:15 – 10:30 Mallery Quetawki, University of New Mexico 61 Mentor: Catherine Egli, M.D. A Statistical Analysis on the Prevalence of Celiac Disease Among Type 1 Diabetic Children and Adolescents Based on Gender, Ethnicity, BMI, and Height and Weight Percentages 10:30 – 10:45 Jacob A. Hartman-Kenzler, Berkeley High School 7 Mentor: Robert Ryan, Ph.D. Mechanism of Amphotericin B Dependant Yeast Growth Inhibition 10: – 11:00 Break Session Jung Suh, Ph.D., Assistant Staff Scientist Chairs: Nathan Shaw, Acalanes High School 11:00 – 11:15 Sara Price, El Cerrito High School 9 Mentor: Frans Kuypers, Ph.D. Hemolyzed Red Blood Cells 11:15 – 11:30 Nadia Kaaid, State University of New York at Buffalo Mentors: Andrzej Witkowski, Ph.D., Stuart Smith, Ph.D., D.Sc. Quantification of Baculovirus by Flow Cytometry and its Application in Optimization of Expression of Recombinant Proteins in the Baculovirus-Insect Cell System 11:30 – 11:45 Olayemi Akintunde, University of California, 1 Berkeley Mentors: Shiori Tamamizu-Kato, Ph.D., Vasanthy Narayanaswami, Ph.D. Oxidative Stress Modification of Apolipoprotein E in Environmental Cigarette Smoke 11:45 – 12:00 Stephanie Orth, Chapman University 7 Mentor: Marsha Treadwell, Ph.D. The Effect of Family Stress on Automatic Nervous System Reactivity in Children with Sickle Cell Disease 7 12:00 – 12:15 Tara Streich- Tilles, Yale University 7 Mentors: Beate Illek, Ph.D. Horst Fischer, Ph.D. Regulation of H2O2 Secretion and Duox1 Expression in Fetal Alveolar Type II Cells and A549 Cells 12:15 – 12:30 Carol Umanzor, University of San Francisco 81 Mentors: Janet King, Ph.D., Suruchi Bhatia, Ph.D. A Retrospective View of Vitamin D Deficient Rickets at Oakland Children’s Hospital 2001 – 2006 12:30 – 1:30 Lunch in the Senior Center Courtyard 1:30 – 3:00 Poster Session in the Senior Center Auditorium Ken Akiha, Bowdin College 1 Mentor: Gregory Moe, Ph.D. Identification of Early Intermediate in the Biosynthesis Pathway of the Neisseria meningitidis Group B Capsular Polysaccharide Benjamin Brown, Laney College 19 Mentor: Donald Reason, Ph.D. Testing Biothrax’s Ability to Induce Somatic Hypermutation Tina Chan, California State University East Bay 1 Mentor: Heidi Flori, M.D. Parental Acupuncture Survey Study Julia Chiang, Brown University Mentor: Fernando Viteri, M.D., Sc.D. Absorption and Regulation by CaCo2 Cells of Different Iron Compounds Used as Food Fortifiers Tram Dam, University of California, Berkeley Mentor: Susan Conrad, MD. Risk Factors for Outcome in Type 1 Diabetes 8 Rommel Devera, St. Mary’s College 7 Mentors: Julie Saba, M.D. Ph.D., Yuen Yee Tam, Ph.D. Sphingosine-1-phosphate Levels in Sickle Cell Disease Carolyn Drake, The College Preparatory School 9 Mentor: Vasanthy Narayanaswami, Ph.D. Apolipoprotein E and Aβ Peptide in Alzheimer’s Disease Sara Epstein, Brown University 1 Mentor: Barbara Staggers, M.D. Evaluating the Standard of Care for Adolescent Sexual Assault Victims Daniela G’Mariam, Oakland Technical High School Mentor: Horst Fischer, Ph.D. Effects of the CFTR Chloride Channel on Cellular H2O2 Production Wendy Gordillo, San Francisco State University Mentor: Patsy Wakimoto, Ph.D. Dietary Intake of Local Minority Adolescents in East Oakland Dominique Johnson, California State University 1 Hayward Mentor: Gordon Watson, Ph.D. The Role of Caloric Restriction in the Prolongation of Life and Mimetic Use of Metformin Mawuli Ladzekpo, Howard University Mentor: Ash Lal, M.D. Flow Cytometric Analysis of Sickle Erythrocytes for the Demonstration of Micronucleated Reticulocytes and Howell-Jolly Bodies 9 Genevieve Lawrence, Colby College 7 Mentors: David Martin, M.D., Jeremy Brown, Ph.D., Olga Martinez Transmitting the Epigenetic Silencing of the HPRT Gene Through the Mouse Germline and Culturing Embryonic Stem Cells Grace Liu, Albany High School 9 Mentors: Bruce Ames, Ph.D., David Killilea, Ph.D. The Role of Oxidative Stress in Magnesium Deficiency Jessica Liu, University of California, Berkeley 1 Mentor: Deborah Dean, M.D., M.P.H. Persistence and Mutations in the trpA gene of Chlamydia trachomatis Among Trachoma Patients in Nepal Yessica Martinez, San Francisco State University Mentor: Michael Oda, Ph.D. Site Directed Mutagenesis of Apolipoprotein A-I at positions ∆134-145 Rachel Maxwell-Jolly, University of California, Santa Cruz Mentor: Elizabeth Trachtenberg, Ph.D. Development of a New MALDI-TOF Mass Spectrometry Assay to Search for Novel Single Nucleotide Polymorphisms in KIR2DL5 exon 3 Julian Ramirez, University of California, Santa 6 Cruz Mentor: Deborah Dean, M.D., M.P.H.
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