www.aging-us.com AGING 2021, Vol. 13, No. 13 Research Paper Roxadustat for the treatment of anemia in patients with chronic kidney diseases: a meta-analysis Li Zhang1, Jie Hou1, Jia Li1, Sen-Sen Su1, Shuai Xue2 1Department of Nephrology, The First Hospital of Jilin University, Jilin Province, China 2Department of Thyroid Surgery, The First Hospital of Jilin University, Jilin Province, China Correspondence to: Shuai Xue; email:
[email protected] Keywords: roxadustat, chronic kidney disease, anemia, meta-analysis Received: January 22, 2021 Accepted: May 17, 2021 Published: June 11, 2021 Copyright: © 2021 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Background: Anemia is a common complication of chronic kidney disease (CKD). Treating renal anemia with erythropoiesis-stimulating agents (ESAs) or erythropoietin analogs is effective but has side effects. Therefore, we performed a meta-analysis to assess the efficacy and safety of roxadustat in treating CKD-induced anemia. Methods: We searched publications online and conducted a meta-analysis and calculated relative risks with 95% confidence intervals (CIs) for dichotomous data and mean differences (MD) with 95% CIs for continuous data. Results: Of 110 articles, nine were included that contained 12 data sets and 11 randomized control trials on roxadustat. In the non-dialysis-dependent (NDD) high-dose/low-dose subgroups, the change in hemoglobin (Hb) levels was significantly higher in the roxadustat group than in the placebo group (P<0.0001, P=0.001, respectively).