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International Symposium on Mycoses PROCEEDINGS INTERNATIONAL SYMPOSIUM ON MYCOSES PAN AMERICAN HEALTH ORGANIZATION Pan American Sanitary Bureau o Regional Office of the WORLD HEALTH ORGANIZATION 1970 INTERNATIONAL SYMPOSIUM ON MYCOSES 24-25 February 1970 Washington, D.C. Scientific Publication No. 205 PAN AMERICAN HEALTH ORGANIZATION Pan American Sanitary Bureau * Regional Office of the WORLD HEALTH ORGANIZATION 525 Twenty-third Street, N.W. Washington, D.C. 20037, U.S.A. 1970 NOTE The International Symposium on Mycoses, held under the auspices of the Pan American Health Organization on 24-26 February 1970 at Washington, D.C., was aided in part by grants from the Squibb Institute for Medical Research, Lederle Laboratories, and the U.S. Army Research and Development Command. PARTICIPANTS AND INVITED GUESTS Dr. Donald G. Ahearn Dr. Ismael Conti Díaz Department of Biology Department of Community Medicine Georgia State College College of Medicine Atlanta, Georgia, USA University of Kentucky Lexington, Kentucky, USA Dr. Libero Ajello Mycology Section Dr. John L. Converse National Communicable Disease Center MB Division Atlanta, Georgia, USA Fort Detrick Frederick, Maryland, USA Dr. Johnsie W. Bailey National Institute of Allergy and Infectious Dr. George C. Cozad Diseases Department of Microbiology Bethesda, Maryland, USA University of Oklahoma Norman, Oklahoma, USA Dr. José Ignacio Baldó Instituto Nacional de Tuberculosis Dr. Edouard Drouhet Caracas, Venezuela Service de Mycologie Institut Pasteur Dr. Christel Benitz Paris, France Medical Research Department Cyanamid International Dr. Phyllis Q. Edwards Pearl River, New York, USA Tuberculosis Branch National Communicable Disease Center Dr. John E. Bennett Atlanta, Georgia, USA Infectious Diseases Section National Institute of Allergy and Infectious Dr. Martin Forbes Diseases Lederle Laboratories Bethesda, Maryland, USA Pearl River, New York, USA Dr. Dante Borelli Dr. Michael L. Furcolow Instituto de Medicina Tropical Department of Community Medicine Universidad Central de Venezuela College of Medicine Caracas, Venezuela University of Kentucky Lexington, Kentucky, USA Dr. Humberto Campins Policlínica Barquisimeto Dr. Hans H. Gadebusch Barquisimeto, Venezuela Chemotherapy and Infectious Diseases Section The Squibb Institute for Medical Research Dr. Luis M. Carbonell New Brunswick, New Jersey, USA Department of Microbiology Instituto Venezolano de Investigaciones Dr. James D. Gallagher Científicas Medical Research Department Caracas, Venezuela Cyanamid International Pearl River, New York, USA Dr. Sotiros D. Chaparas Mycobacterial and Fungal Antigens Section Dr. Lucille K. Georg Division of Biologics Stanidards Mycology Section National Institutes of Health National Communicable Disease Center Bethesda, Maryland, USA Atlanta, Georgia, USA iii Major Robert M. Glickman Dr. Margarita Silva Hutner U.S. Army Research and Development Mycology Laboratory Command Columbia University College of Physicians and Washington, D.C., USA Surgeons New York, New York, USA Dr. Mariano Gómez Vidal Centro Dermatalógico "Pascua" Dr. William Kaplan México. D.F., Mexico Mycology Section National Communicable Disease Center Dr. Amado González-Mendoza Atlanta, Georgia, USA Hospital General del Centro Médico Nacional Instituto Mexicano del Seguro Social Dr. Leo Kaufman México, D.F., Mexico Mycology Section National Communicable Disease Center Dr. Antonio González Ochoa Atlanta, Georgia, USA Departamento de Dermatología Tropical Instituto de Salubridad y Enfermedades Dr. David Kirsh Tropicales Licensure and Performance Evaluation Section México, D. F., Mexico National Communicable Disease Center Atlanta, Georgia, USA Dr. Sarah Grappel Skin and Cancer Hospital Dr. J. R. Knill The Squibb Institute for Medical Research Temple University New Brunswick, New Jersey, USA Philadelphia, Pennsylvania, USA Mr. William S. Knop Dr. Donald Greer E. R. Squibb & Sons Inc. International Center for Medical Research and New York, New York, USA Training University of Valle Mr. Richard H. Kruse Cali, Colombia Industrial Health and Safety Directorate Fort Detrick Professor E. 1. Grin Frederick, Maryland, USA Institute of Dermato-Venereology Sarajevo, Yugoslavia Dr. Marshall Landay Department of Epidemiology and Public Health Dr. Leanor D. Haley The George Washington University Medical Mycology Training Unit School National Communicable Disease Center Washington, D.C., USA Atlanta, Georgia, USA Dr. Howard W. Larsh Dr. H. F. Hasenclever Department of Botany and Microbiology Medical Mycology Section University of Oklahoma National Institute of Allergy and Infectious Norman, Oklahoma, USA Diseases Bethesda, Maryland, USA Dr. Ramón F. Lazo Departamento de Parasitología Universidad de Guayaquil Dr. Abraham Horwitz Guayaquil, Ecuador Pan American Health Organization Washington, D.C., USA Dr. H. B. Levine Medical Microbiology Department Dr. Milton Huppert School of Public Health Mycology Research Laboratory University of California, Berkeley Veterans Administration Hospital Naval Biological Laboratory San Fernando, California, USA Oakland, California, USA iv Dr. A. T. Londero * Professor Pablo Negroni Instituto de Parasitologia e Micologia Centro de Micología Universidade de Santa Maria Facultad de Ciencias Médicas Santa Maria, Rio Grande do Sul Universidad de Buenos Aires Brazil Buenos Aires, Argentina Dr. Donald B. Louria Dr. F. C. Ottati New Jersey College of Medicine and Dentistry Medical Research Department Newark, New Jersey, USA Cyanamid International Pearl River, New York, USA Dr. Edwin P. Lowe Mycology Division Dr. Angulo Ortega Fort Detrick Instituto Nacional de Tuberculosis Frederick, Maryland, USA Caracas, Venezuela Dr. Donald W. MacKenzie Dr. Demosthenes Pappagianis Department of Microbiology Department of Medical Microbiology Cornell University Medical College University of California School of Medicine New York, New York, USA Davis, California, USA Dr. Juan E. Mackinnon Dr. Ladislao Pollak Facultad de Medicina Departamento de Bacteriología Instituto de Higiene Instituto Nacional de Tuberculosis Montevideo, Uruguay Caracas, Venezuela Dr. Ernesto Macotela-Ruíz Dr. Angela Restrepo M. Hospital General del Centro Médico Nacional Departamento de Microbiología y Parasitología Instituto Mexicano del Seguro Social Facultad de Medicina México, D.F., Mexico Universidad de Antioquia Medellín, Colombia Dr. F. Mariat Service de Mycologie Dr. Mario Robledo V. Institut Pasteur Departamento de Microbiología y Parasitología Paris, France Facultad de Medicina Universidad de Antioquia Dr. M. Martins da Silva Medellín, Colombia Pan American Health Organization Washington, D.C., USA Dr. John A. Schmitt Faculty of Botany Dr. Rubén Mayorga Ohio State University Laboratorio de Micología Columbus, Ohio, USA Departamento de Microbiología Facultad de Ciencias Químicas y Farmacia Dr. John H. Seabury Universidad de San Carlos School of Medicine Guatemala, Guatemala Louisiana State University New Orleans, Louisiana, USA Dr. P. Montero-Gei Dr. Edward B. Seligmann Departamento de Microbiología Laboratory of Control Activities Universidad de Costa Rica Division of Biologics Standards San José, Costa Rica National Institutes of Health Bethesda, Maryland, USA Dr. Harold G. Muchmore University of Oklahoma Medical Center Dr. Smith Shadomy Oklahoma City, Oklahoma, USA Medical College of Virginia Virginia Commonwealth University * Unable to attend. Richmond, Virginia, USA v Mr. David Taplin Dr. J. P. Utz Department of Dermatology Medical College of Virginia University of Miami School of Medicine Virginia Commonwealth University Miami, Florida, USA Richmond, Virginia, USA Dr. Fred E. Tosh Dr. Nardo Zaias Ecological Investigations Program Department of Dermatology National Communicable Disease Center University of Miami School of Medicine Kansas City, Kansas, USA Miami, Florida, USA PROGRAM COMMITTEE Dr. Libero Ajello (Consultant) Dr. Antonio González Ochoa National Communicable Disease Center Instituto de Salubridad y Enfermedades Atlanta, Georgia, USA Tropicales México, D.F., Mexico Dr. José Ignacio Baldó Dr. M. Martins da Silva (Secretary) Instituto Nacional de Tuberculosis Pan American Health Organization Caracas, Venezuela Washington, D.C., USA vi CONTENTS Page Participants and Invited Guests ...................................................... iii Session I. The Mycoses as a Major Public Health Problem The Medical Mycological Iceberg Libero Ajello ....................................... 3 Prevalence of Cutaneous Mycoses in Latin America A. T. Londero ..................... 13 Prevalence of Subcutaneous Mycoses in Latin America Rubén Mayorga .................. 18 Prevalence of Systemic Mycoses in Latin America Dante Borelli ...................... 28 Opportunistic Mycoses Amado González-Mendoza .................................... 39 Discussion .......................................................... 45 Session II. Recent Advances in Diagnostic Procedures Experience with a New Indicator Medium (DTM) for the Isolation of Dermatophyte Fungi David Taplin, Alfred M. Allen, and Patricia Mann Mertz ......................... 55 Isolation and Identification Media for Systemic Fungi Howard W. Larsh ............... 59 Systematics of Yeasts of Medical Interest Donald G. Ahearn ........................... 64 Diagnostic Procedures for the Isolation and Identification of the Etiologic Agents of Actino- mycosis Lucille K. Georg ..................................................... 71 Discussion ........................................ 82 The Fluorescent Antibody Technique in the Diagnosis of Mycotic
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