UCLA Stein Eye Institute Annual Report 2017-2018

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ANNUAL REPORT 2014–2015 Stein Eye Institute UCLA Stein Eye Institute VISION-SCIENCE CAMPUS

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ANNUAL REPORT 2017–2018ANNUAL REPORT Annual Report 2016–2017

THE ONLY BARRIER TO A CURE Benefactor: Benefactor: Uncle Claude IS ACCESS Uncle Claude TO CARE.

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David Geffen School of Medicine at UCLA University of California, Los Angeles Benefactor: Benefactor: Uncle Claude Uncle Claude

Benefactor: Uncle Claude Stein Eye Institute ANNUAL REPORT

July 1, 2017– June 30, 2018

DIRECTOR Bartly J. Mondino, MD

MANAGING EDITOR Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 [email protected]

PUBLICATION COMMITTEE Anthony C. Arnold, MD Kevin M. Miller, MD Alapakkam P. Sampath, PhD Alfredo A. Sadun, MD, PhD M. Gail Summers

CONTRIBUTING EDITORS Teresa Closson Susan Ito Sarah Johnson Peter J. López Ellen Pascual Debbie Sato

CONTRIBUTING WRITERS Dan Gordon Harlan Lebo

PHOTOGRAPHY Reed Hutchinson J. Charles Martin Robin Weisz

DESIGN Robin Weisz/Graphic Design

PRINTING Colornet Press

To view the Annual Report online, visit: www.uclahealth.org/Eye/annual-report

For more information about the Institute, see: www.uclahealth.org/eye/

Saving Sight Across the Globe 2 Institute News 5 Faculty Honors 6 New Faculty Appointments 7 In Memoriam 8 Research 10 Education 12 Community Outreach 15 Alumni 16 JSEI Affiliates 17 Philanthropy 18 Thank You 19 Jules and Doris Stein 25 Board of Trustees and Executive Committee 27

FACULT Y 31

PROGRAMS 93

Patient Care Services 94 Research and Treatment Centers 97 Clinical Laboratories 102 Training Programs 104

APPENDICES 109

Volunteer and Consulting Faculty 110 Residents and Fellows 112 Research Contracts and Grants 114 Clinical Research Studies 127 Publications of the Full-Time Faculty 135 Giving Opportunities 146 DEAR FRIENDS

Dr. Jules Stein envisioned a world where everyone can see, and the UCLA Stein Eye Institute was borne upon the promise of eradicating eye disease and preventing avoidable blindness. Our commitment to fulfill Dr. Stein’s dream extends throughout the United States and across all borders.

Together with our affiliation partner, the Doheny Eye Institute, we are advancing vision-science research and setting a global standard for patient care. At any given time, UCLA Department of Ophthalmology doctors, residents, fellows, and alumni are delivering medical care in countries throughout the world, serving children and adults in regions with great need.

I thank our physicians and researchers who are dedicated to achieving Dr. Stein’s vision. Through their tireless work, they are giving sight to countless individuals who thought their lives would be lived in darkness.

I thank you, our donors and friends. Because of your partnership in our mission, there is hope that future generations will no longer need fear being blinded by eye disease. The impact of our collective investment in blindness prevention, both here at home and abroad, is incalculable.

Please enjoy these highlights of our 2017–2018 academic year, which reflect our efforts to ensure that people the world over have the gift of sight.

Sincerely,

Bartly J. Mondino, MD

Bradley R. Straatsma, MD, Endowed Chair in Ophthalmology Director, Stein Eye Institute Chairman, UCLA Department of Ophthalmology Affiliation Chairman, Doheny Eye Institute UCLA Department of Ophthalmology ACADEMIC DIVISIONS

CATARACT AND NEURO-OPHTHALMOLOGY RETINAL DISEASES AND REFRACTIVE SURGERY Anthony Arnold, MD, Chief SEI OPHTHALMIC GENETICS John Bartlett, MD Laura Bonelli, MD Michael Gorin, MD, PhD, Chief Kenneth Lu, MD Lynn Gordon, MD, PhD Phillip Le, MD, PhD Kevin Miller, MD, Chief Stacy Pineles, MD Colin McCannel, MD Mitra Nejad, MD Peter Quiros, MD Steven Nusinowitz, PhD Optometrists Alfredo Sadun, MD, PhD, Chief DEI SriniVas Sadda, MD Carolyn Duong, OD David Sarraf, MD Linda Hwang, OD OPHTHALMIC PATHOLOGY Mark Landig, OD Ben Glasgow, MD VISION SCIENCE Amanda Powers, OD Suraj Bhat, PhD ORBITAL AND OPHTHALMIC Gordon Fain, PhD COMPREHENSIVE OPHTHALMOLOGY PLASTIC SURGERY Debora Farber, PhD, DPhhc Gavin Bahadur, MD Robert Goldberg, MD, Chief Joseph Horwitz, PhD Rachel Feit-Leichman, MD Daniel Rootman, MD Wayne Hubbell, PhD Tania Onclinx, MD Steven Nusinowitz, PhD Susan Ransome, MD PEDIATRIC OPHTHALMOLOGY Natik Piri, PhD Meryl Shapiro-Tuchin, MD AND STRABISMUS Roxana Radu, MD Ronald Smith, MD Joseph Demer, MD, PhD, Chief Alapakkam Sampath, PhD, Chief Simon Fung, MD Deming Sun, MD Optometrists Sherwin Isenberg, MD Hui Sun, PhD Michael Baker, OD Monica Khitri, MD Gabriel Travis, MD Vivian Shibayama, OD Stacy Pineles, MD David Williams, PhD

Federico Velez, MD Xian-Jie Yang, PhD CORNEA AND UVEITIS Jie Zheng, PhD Anthony Aldave, MD, Chief SEI Optometrist Saba Al-Hashimi, MD Laura Robbins, OD Benjamin Bert, MD Richard Casey, MD RETINA Sophie Deng, MD, PhD Gad Heilweil, MD Gary Holland, MD Jean-Pierre Hubschman, MD Hugo Hsu, MD, Chief DEI Hamid Hosseini, MD John Irvine, MD Michael Ip, MD, Chief DEI Batool Jafri, MD Ali Khan, MD Olivia Lee, MD Allan Kreiger, MD Ralph Levinson, MD Tara McCannel, MD, PhD Bartly Mondino, MD, Chairman Pradeep Prasad, MD Steven Schwartz, MD, Chief SEI GLAUCOMA Irena Tsui, MD Find out more about UCLA Joseph Caprioli, MD, Chief SEI Optometrists Department of Ophthalmology Vikas Chopra, MD Melissa Chun, OD Academic Divisions and our Anne Coleman, MD, PhD Jennie Kageyama, OD faculty at: www.uclahealth.org/ Brian Francis, MD, Chief DEI eye/academic-divisions. JoAnn Giaconi, MD Alex Huang, MD, PhD Simon Law, MD, PharmD Kouros Nouri-Mahdavi, MD Natik Piri, PhD James Tan, MD, PhD

A Year in Review | Stein Eye Institute 1 SAVING SIGHT ACROSS THE GLOBE

At any given time, UCLA Department of Ophthalmology doctors, residents, fellows, and alumni are advancing eye health and eradicating blindness throughout the world.

A YEAR IN REVIEW

JULY 1, 2017–JUNE 30, 2018

ur work has no borders,” says Bartly J. Mondino, MD, director of the Stein Eye Institute and chairman of the OUCLA Department of Ophthalmology. “We are dedicated to preserving and restoring sight both here at home and abroad.” The World Health Organization reports that an estimated 39 million people are blind—yet up to 80% of these cases could be easily prevented or treated if individuals had access to vision care. Taking this call to action, Stein Eye ophthalmologists bring their specialized skills to underserved regions where avoidable blindness is most prevalent. “More than 230 international fellows from throughout the world have trained at Stein Eye. They then bring this subspecialty clinical and research expertise back to their home country, advancing eye care in their region,” says Dr. Mondino. “In addition to our fellows, Stein Eye faculty, staff, and alumni have shown incredible leadership in their outreach efforts.”

2 Stein Eye Institute | A Year in Review Dr. Bradley Straatsma, founding director of the UCLA Stein Eye Institute, was instrumental in the creation of the Magrabi ICO Cameroon Eye Institute in Yaoundé.

MICEI is the first not-for- profit subspecialty and training eye hospital in the Central Africa Region.

Changing the Quality of Life “By providing subspecialty ser- in Sub-Saharan Africa vices and advanced training,” says Dr. Straatsma, “MICEI is enhancing vision Bradley R. Straatsma, MD, JD, found- and the quality of life for individuals, ing director of the Stein Eye Institute families, and ultimately all of society in and founding chairman of the UCLA Sub-Saharan Africa.” Department of Ophthalmology, is a shining example of how one person can make a difference in the lives of Volunteer Organizations so many. Making a Global Difference Dr. Straatsma led UCLA into becom- Ending corneal blindness is the inspired ing one of the world’s premier cen- mission of Visionaries International, ters for vision research, education, and a non-profit volunteer organization patient care, and he was recently instru- founded by Stein Eye faculty member mental in the development of the first Anthony J. Aldave, MD, Walton Li subspecialty and training eye hospital in Chair in Cornea and Uveitis. the Central Africa region: the Magrabi “The consequences are especially ICO Cameroon Eye Institute (MICEI) in serious in the developing world, where Yaoundé, Cameroon. 90 percent of all corneal blind live,” “Blindness is closely linked with says Dr. Aldave, chief of the Institute’s extreme poverty and significantly short- Cornea and Uveitis Division. “Lack of er life spans, especially in poorer coun- transplantable corneas and inadequate tries. Independent of a patient’s ability numbers of trained transplant surgeons to pay, MICEI offers services for cata- are the main barriers to treatment.” To ract, cornea, glaucoma, neuro-ophthal- combat these obstacles, Dr. Aldave mology, orbit and oculoplastic surgery, and dedicated volunteers “train the pediatric ophthalmology, refractive sur- trainers” in performing newer forms of gery, in addition to retina and vitreous corneal transplantation to treat corneal surgery,” says Dr. Straatsma. The not- blindness. for-profit eye center officially opened in Stein Eye alumnus Harry S. Brown, 2017 and provided vision care for 20,000 MD, FACS, established Surgical Eye patients its inaugural year. Expeditions (SEE) International in 1974 Teaching sight-saving procedures to prevent blindness and restore vision to eye health providers is a critical tool to disadvantaged individuals worldwide for advancing vision care. Jean-Pierre by providing sustainable medical, surgi- Hubschman, MD, Stein Eye associ- cal, and educational services. ate professor of ophthalmology, was The alumnus organization has grown MICEI’s first Visiting Professor and to more than 650 volunteers from over conducted the hospital’s first vitreo- 75 different countries. To date, SEE retinal surgery with Henry Nkumbe, has conducted 500,000 surgeries and MD, MICEI’s medical director. provided free vision screenings to 3.8 million individuals in over 80 countries.

A Year in Review | Stein Eye Institute 3 Protecting Children’s Vision Across the World Corneal infections from bacteria are the world’s leading cause of preventable blindness in children. Leonard Apt, MD, the late founding chief of the Division of Pediatric Ophthalmology, and Sherwin J. Isenberg, MD, Laraine and David Gerber Chair in Ophthalmology, were key participants in one of the most significant breakthroughs in pediatric vision care: they identified povidone- iodine (betadine) as a practical, low-cost solution for preventing neonatal eye infections. “In low-resource countries,” explains Dr. Isenberg, “antibiotics are unafford- able so infections would go untreated, and babies would go blind. Povidone- iodine changed that, as it costs pennies. The treatment is now used globally.” Institute doctors also work with physicians and institutions overseas to give children a brighter future. As an example, Irena Tsui, MD, assistant professor of ophthalmology, and her international colleagues, are exploring the effects Dr. Irena Tsui (left) and Dr. Andrea Zin in Rio de Janeiro, Brazil, examining the retina of an infant of Zika virus on infants in Brazil. Their with Zika-related eye findings. study results indicate that all infants born during Zika virus epidemics should undergo screening eye examinations, as eye abnormalities can be the only initial finding in congenital Zika virus infection.

Making a Difference Here at Home “The vast majority of vision problems in underserved populations are treatable,” says Anne L. Coleman, MD, PhD, The Fran and Ray Stark Foundation Chair in Ophthalmology. As Director of the Stein Eye Institute Centers for Community Outreach and Policy, Dr. Coleman oversees the UCLA Mobile Eye Clinic, which has provided free care to more than 300,000 underserved children and adults in Los Angeles County since it began operations in 1975. “The importance Stein Eye places on caring for our most vulnerable populations cannot be overstated,” says Dr. Coleman. “The only barrier to a cure is access to care.” Dr. Anthony Aldave (left) assists a Thai ophthalmologist during a Descemet stripping endothelial keratoplasty workshop in Bangkok, Thailand. Dr. Aldave founded Visionaries International to “train the trainers” in an effort to eliminate corneal blindness worldwide.

4 Stein Eye Institute | A Year in Review Institute News

Doheny Eye Institute Marks 70 Years of Care The Doheny Eye Institute began in 1947, Fifty Years of Vision with the launch of its forerunner, the The original dream for ophthalmology at UCLA has evolved into the Estelle Doheny Eye Foundation, which Institute’s bold transformation to a vision-science campus. was founded by Mrs. Carrie Estelle The book “50 Years of Vision: 1966–2016,” published in 2017, com- Doheny in the desire to make a posi- memorates the UCLA Stein Eye Institute’s five decades of achievement, tive difference in people’s lives by sav- chronicling the Institute’s history and half-century of growth. ing sight. “In its 70-year history, Doheny Eye Institute ophthalmologists and vision- scientists have made major clinical and research advances,” says Bartly J. Mondino, MD, chairman of the UCLA Department of Ophthalmology and affiliation chairman of the Doheny Eye Insti- tute. “Under the leadership of Execu- tive Director Marissa Goldberg, and President and Chief Scientific Officer SriniVas R. Sadda, MD, they are poised for a future filled with new innovations and discoveries.”

New Leadership Roles As the first Vice-Chairman for Education, Anthony C. Arnold, MD, is the primary supervisor for UCLA weekly grand rounds, the annual seminar, and the UCLA neuroscience seminar. He is an advisor to the residency program director, and he assists in departmental continuing medical education activities. In addition, he provides oversight for affiliated training sites, fellowship programs, and undergraduate and graduate medical education. Dr. Arnold is also newly appointed to the Executive Committee of the Stein Eye Institute and UCLA Department of Ophthalmology Previously serving as associate residency director for the UCLA Department of Ophthalmology, Stacy L. Pineles, MD, has been named the program’s director, taking over the position previously held by Dr. Arnold. As Associate Director of the Vision Science Division, Alapakkam P. Sampath, PhD, provides operational oversight of the Division and its laboratory research. Gabriel H. Travis, MD, stepping down as a co-director, will serve as a special advisor to the Executive Committee.

A Year in Review | Stein Eye Institute 5 2017 AAO Annual Meeting Faculty Honors Robert Alan Goldberg, MD, Karen and Frank Dabby Endowed Chair in UCLA Department of Ophthalmol- Anthony J. Aldave, MD, Walton Li Chair Ophthalmology, received the Robert H. ogy faculty, staff, and alumni were in Cornea and Uveitis, was invited to give Kennedy Presidential Award from the honored at the November 11–14, the David Easty Lecture by the Bowman American Society of Ophthalmic Plastic 2017, American Academy of Oph- Club, the UK Corneal Society. The lec- & Reconstructive Surgery, November thalmology Annual Meeting in New ture was given in Newcastle upon Tyne, 10, 2017, in New Orleans, Louisiana. Orleans, Louisiana. United Kingdom, on March 23, 2018. In addition, Dr. Aldave gave a plenary Life Achievement Honor Award lecture at the 6th Biennial Asia Cornea Baruch D. Kuppermann, MD Michael S. Ip, MD, professor of oph- Society meeting in Qingdao, China, on thalmology, presented the Alex E. Paul P. Lee, MD, JD May 17, 2018. Kevin M. Miller, MD Krill Memorial Lecture at the Chicago Jay Stuart Pepose, MD, PhD Ophthalmological Society meeting on Alfredo A. Sadun, MD, PhD December 4, 2017, in Chicago, Illinois. Anthony C. Arnold, MD, professor In addition, Dr. Ip was the keynote of clinical ophthalmology, has been Senior Achievement Award speaker at the Milwaukee Ophthalmo- appointed Mary Oakley Foundation Chair Joseph L. Demer, MD, PhD logical Society meeting on April 24, in Neurodegenerative Disease. Christina Joy Flaxel, MD 2018, in Milwaukee, Wisconsin. JoAnn A. Giaconi, MD David Sarraf, MD Anne L. Coleman, MD, PhD, The Fran Neda Shamie, MD Bartly J. Mondino, MD, Bradley R. and Ray Stark Foundation Chair in Oph- Paul A. Sidoti, MD Straatsma, MD, Endowed Chair in thalmology, was the keynote speaker at Ophthalmology and chairman of the Achievement Award the 16th Annual Downeast Ophthalmol- UCLA Department of Ophthalmology, Mina M. Chung, MD ogy Symposium, September 16, 2017, delivered the Inaugural C. Stephen Troy R. Elander, MD in Bar Harbor, Maine. Foster, MD, Lecture at the 2018 Sonoma Troy M. Tanji, MD Dr. Coleman also presented the key- Eye, March 23–25, 2018, in Sonoma, Kristina Tarczy-Hornoch, MD note address at the Australian and New California. Stephen H. Tsang, MD, PhD Zealand Glaucoma Symposium during Fei Yu, PhD the Royal Australian and New Zealand College of Ophthalmologists Scientific Stacy L. Pineles, MD, Associate Profes- Secretariat Award Congress, November 1, 2017, in Perth, sor of Ophthalmology, has been named Gary N. Holland, MD Australia. the Jerome and Joan Snyder Chair in Ophthalmology.

Joseph L. Demer, MD, PhD, Arthur L. Rosenbaum, MD, Chair in Pediatric Peter A. Quiros, MD, health sciences Ophthalmology, delivered the key- associate clinical professor, was elected note address to the Japanese Neuro- to a two-year term as president of the Ophthalmology Society on November Latin American Neuro-Ophthalmology 10, 2017, in Yokohama, Japan. Club. Dr. Demer was also honored with a Lifetime Achievement Award from the American Association for Pediatric Oph- SriniVas R. Sadda, MD, professor thalmology and Strabismus on March of ophthalmology, received the Presi- 18, 2018, in Washington, D.C. dents’ Young Investigator Award from the American Society of Retina Spe- cialists (ASRS) on August 14, 2017, at the ASRS annual meeting in Boston, Massachusetts.

6 Stein Eye Institute | A Year in Review David Sarraf, MD, health sciences Best in the West New Faculty Appointments clinical professor of ophthalmology, UCLA Health is consistently ranked received the LuEsther T. Mertz Lecture- Specializing in infections of the cornea, among the best hospitals in the coun- ship Award from The Macula Founda- Saba Al-Hashimi, MD, health sciences try by U.S. News & World Report, tion, on April 10, 2018, in New York, New assistant clinical professor, joined the and UCLA Stein Eye and Doheny Eye York. Dr. Sarraf also presented the Mark UCLA Department of Ophthalmology Institutes are ranked among the top five J. Daily, MD, Retina Lecture at the 29th faculty on July 10, 2017. in the nation in ophthalmology. Loyola Ophthalmology Resident Alumni Day held at Loyola University on June 8, 2018, in Chicago, Illinois. Benjamin B. Bert, MD, health sciences In addition, The Retinal Atlas, 2nd assistant clinical professor, became a Edition, by Dr. Sarraf and co-authors, UCLA Department of Ophthalmology received highly commended honors at faculty member on July 1, 2017. He the 2017 British Medical Association specializes in cornea-external ocular Medical Book Awards on September disease and refractive surgery. 18, 2017, in London, United Kingdom.

Simon Fung, MD, a specialist in adult David S. Williams, PhD, professor of and pediatric cornea and anterior seg- neurobiology, received a $2.3 million ment, began his faculty appointment as grant for research on RPE cell biology, an assistant professor of ophthalmology aging, and disease from the National Eye on January 11, 2018. Institute, National Institutes of Health on September 1, 2017. Dr. Williams also received two Hamid Hosseini, MD, assistant pro- awards from the Foundation Fighting fessor of ophthalmology, specializes Blindness on October 16, 2017: a New in retinal and macular conditions. He Foundation Fighting Blindness Individ- was promoted to his current position ual Investigator Award of $300,000 for on August 1, 2017. studies on gene editing to treat Usher syndrome, and a New Foundation Fight- ing Blindness Program Project Award of $2.5 million for collaborative research on understanding Usher syndrome and choroideremia.

A Year in Review | Stein Eye Institute 7 David R. Fett, MD

David R. Fett, MD, associate clinical professor of ophthalmology, passed away from a heart attack on August 3, 2017. Following his undergraduate education at the Massachusetts Institute of Technology, Dr. Fett graduated from the Geisel School of Medicine at Dartmouth. He conducted his residency training at the UCLA Stein Eye Institute (1981– 1984) and then completed a fellowship in ophthalmic plastic surgery at the University of Illinois in Chicago. Upon his return to Los Angeles, Dr. Fett began a successful private practice in oculoplastic surgery, performing approximately 40,000 surgeries by the time he retired in 2016. Passionate about education and help- ing others, Dr. Fett spoke publicly about the importance of giving back. A leader in the community, Dr. Fett was an active member of the Leo Baeck Temple, supported his alma maters, and served on advisory boards. As a volunteer clinical faculty member at the UCLA Stein Eye Institute, he furthered the education of residents and fellows. Among his philanthropic gifts, he supported the training of fellows with the establishment of the David and Randi Fett Orbital and Ophthalmic Plastic Surgery Fellowship Endowment. “Dr. Fett was a great friend, colleague, and supporter of UCLA,” says Bartly J. Mondino, MD, director of the Stein Eye Institute. “Through his academic contributions and his generous philanthropy, he has advanced the education of generations of Stein Eye residents and fellows.”

8 Stein Eye Institute | A Year in Review IN MEMORIAM

Henry I. Baylis, MD

Henry I. Baylis, MD, found- established in 1981—with the vision and support of Institute ing chief of the UCLA Stein Founding Director, Bradley R. Straatsma, MD, JD. Eye Institute Orbital and Dr. Baylis regularly presented at the American Society of Ophthalmic Plastic Surgery Ophthalmic Plastic and Reconstructive Surgery (ASOPRS), Division, died September 19, and the annual Baylis Lecture at the ASOPRS meeting honors 2017. Dr. Baylis’s leadership in ae sthetic oculofacial surgery. In addi- Dr. Baylis was born in tion to writing respected academic articles and running a busy Pontiac, Michigan, in 1935 clinic, he founded the premier subspecialty publication, Journal and attended medical school of Ophthalmic Plastic and Reconstructive Surgery. To further at the University of Michigan. education in the field, Dr. Baylis started the ASOPRS Fellowship He conducted his residency at UCLA in 1975, which has since trained 60 fellows. at the University of California “Hank’s career was characterized by imagination and bold San Francisco and trained in innovation. His numerous articles on surgical technique intro- ophthalmic plastic surgery in duced ideas that have become cornerstones of our specialty,” New York. says Robert Alan Goldberg, MD, chief of the Orbital and Soon after arriving in Los Angeles to open his medical practice, Ophthalmic Plastic Surgery Division. Dr. Baylis joined the clinical faculty of the UCLA Stein Eye Through his foresight and leadership, Dr. Baylis saw his field Institute. Combining a passion for the discipline with an inno- transform to a robust discipline with an accredited subspe- vative approach to teaching and surgery, Dr. Baylis created cialty curriculum, academic divisions in almost every university an innovative and academically robust Division—formally ophthalmology program, and wide respect from colleagues in related specialties. Dr. Baylis is survived by his three children, two gr andchildren, and his wife, Barbara Baylis.

Honoring the Life Work of Dr. Henry Baylis To recognize Dr. Baylis’s remarkable contributions to both academic medicine and ophthalmology, the Stein Eye Institute established the Henry I. Baylis, M.D. Fund in Orbital and Ophthalmic Surgery to support the research activities of the Orbital and Ophthalmic Plastic Surgery Division. Due to initial generous support from alumni and colleagues, the fund was converted to an endowment. The aim is to raise $2 million, so an administrative chair may be established. “Dr. Baylis was a true pathfinder, and we endeavor to fully honor his legacy,” says Bartly J. Mondino, MD, director of the Stein Eye Institute and chairman of the UCLA Department of Ophthalmology. “We thank our alumni and friends for their continued commitment to outstanding members of the UCLA family.” For information on how you can support the chair campaign in honor of Dr. Baylis, contact Director of Development, M. Gail Summers, at: [email protected] or 310-206-9701.

Dr. Baylis, center, an innovative and influential leader in the field of orbital and ophthalmic plastic surgery, trained generations of ophthalmologists in the subspecialty.

A Year in Review | Stein Eye Institute 9 Research

Repetitive Strain Injury to the Optic Nerve Could Play an Important Role in Some Glaucoma Cases

It has been long believed that glaucoma Stein Eye researchers are investigat- is caused by damage to the optic nerve ing a new concept with major implica- due to elevated intraocular pressure. But tions for the second-leading cause of that may not be the case for many peo- blindness worldwide: the possibility ple who have glaucoma. “In Western that many cases of glaucoma can be populations, as many as half of people attributed in part to repetitive strain with glaucoma have intraocular pres- injury to the optic nerve caused by every- Computer simulation, by finite element analysis, of mechanical strain in the optic sure in the normal range, and in certain day eye movements. nerve head and adjacent eye wall caused by Asian populations, approximately 90 “If this turns out to be the case, it tethering of the optic nerve sheath during percent have normal pressure,” says could be a major breakthrough,” says adduction eye movement. This simulation incorporates a combination of biomechanical Joseph Caprioli, MD, David May II Joseph L. Demer, MD, PhD, Arthur properties—all measured in tissues donated Chair in Ophthalmology and chief of L. Rosenbaum, MD, Chair in Pediatric to eyebanks—that are predicted to result in the Glaucoma Division at the UCLA Ophthalmology, chief of the Pediatric glaucomatous optic nerve damage over a Stein Eye Institute. Because of that, Dr. Ophthalmology and Strabismus Division, lifetime of eye movements. (Credit: simulation and graphic by Joseph Park, MS, using data Caprioli notes, intraocular pressure is and director of the Ocular Motility collected by Andrew Shin, Joseph Park, and Joseph now considered a glaucoma risk factor, Clinical and Basic Science Laboratory. L. Demer.) but not a defining characteristic.

10 Stein Eye Institute | A Year in Review Stein Eye researchers are investigating a new concept with major implications: the possibility that many cases of glaucoma can be attributed in part to repetitive strain injury to the optic nerve caused by everyday eye movements.

“Currently, intraocular pressure is the used a technique called finite element the eye gets pulled back into the socket, only significant modifiable risk for glau- analysis, which is used by mechani- and the optic nerve head is deformed.” coma, but most cases of glaucoma cal engineers to calculate how certain Dr. Demer and his collaborators are occur at normal, not elevated, pressure.” stresses will affect small elements in continuing to test their hypothesis. They During his research using magnetic structures. In the finite element model, have established a biomechanics labora- resonance imaging (MRI) to learn about which is run on a supercomputer sys- tory, and using eye bank tissue provided eye muscle function, Dr. Demer began tem at UCLA, researchers rotated the by donors with and without glaucoma, to hypothesize that the types of eye eye beyond the point where the optic they are measuring the elasticity and movements people make tens of thou- nerve ran out of slack, and found this viscosity of various parts of the human sands of times a day might contribute commonly encountered additional rota- eye. They are combining that work with to some cases of glaucoma. “We would tion produced stresses and strains in microscopic analysis of the connected have our volunteers make large eye the places that commonly show clin- tissues in the same eyes in an effort to movements as they were undergoing ical damage with age—particularly in correlate the microscopic appearance scanning, and we noticed there are patients who have glaucoma at normal and chemical composition of the tissues certain gaze positions where the optic intraocular pressure. with their mechanical behavior. They are nerve isn’t quite long enough to allow Next, the researchers used optical also testing the clinical implications in the eye to rotate freely without it tighten- coherence tomography (OCT) to view larger groups of patients. ing,” he says. The most notable of these the eye over a range of gaze positions The researchers are studying also positions is adduction, in which the eye and found that the optic nerve head the potential connection between the rotates inwardly toward the nose. “In rocks back and forth as the eye rotates, tethering of the optic nerve and the almost everyone, that causes the optic most notably in the adduction position. elongation of the eye that is character- nerve to use up all of its available slack “This confirmed our prediction that optic istic of myopia (nearsightedness). “The and become tight, pulling on the back nerve tethering should cause visible dis- glaucomatous condition of the optic of the eye,” Dr. Demer explains. “We tortion,” Dr. Demer says. “And in fact, nerve seems to be more prevalent and recognized from MRI that these move- the amount of distortion of the optic important in myopia,” Dr. Caprioli says. ments impose a great deal of strain on nerve tissues that we can see with OCT “This might explain the extra glaucoma the junction of the highly mobile eyeball is far greater during adduction than it is risk conferred by myopia.” with the optic nerve, which is the cable when intraocular pressure is elevated Overall, Dr. Caprioli notes, “this work, that conveys vision to the brain.” during an acute attack of glaucoma.” if confirmed, would add an important This is significant, Dr. Demer notes, Following these observations, Dr. risk factor for glaucoma that could lend because that junction—called the optic Demer’s group conducted a clinical itself to treatment.” disc or optic nerve head—is the point study of glaucoma patients who have where glaucoma damage is known to normal intraocular pressure, comparing occur. “The site of the most common them with a control group of healthy vol- damage we see is on the temporal edge unteers of comparable ages and another of the optic disc, which is the edge that group of patients who have strabismus gets most tightly pulled when the eye but not glaucoma. Of the three groups, rotates inwardly toward the nose,” Dr. only the glaucoma patients showed sub- Demer says. “As people get older, the stantial eyeball retraction during adduc- optic nerve head changes in appear- tion movements. ance. Most patients develop a depres- Then, looking at the microanatomy of sion in the center that increases in size, the tissues from anatomical donations, and the nerve head tilts in the direction the researchers found that in some older where these forces are pulling. Over people, the optic nerve sheath thickens time, the edge of the eye wall adjacent and stiffens, much like the sclerosis that to the optic disc begins to atrophy in a occurs in the arteries. “We are find- crescent-shaped pattern in the majority ing that when the optic nerve pulls up of people.” tight in younger people, it harmlessly To test the plausibility that these stretches without applying excessive changes are results of the accumula- force to the back of the eye,” Dr. Demer tion of wear and tear from adduction explains. “But as some people get older eye movements, Dr. Demer’s team and the sheath becomes less elastic,

A Year in Review | Stein Eye Institute 11 Education

Club LatinoAmericano de Comprehensive Resident and Fellow Neuro-oftalmologia Ophthalmology Review Course Graduation Award The Club LatinoAmericano de Neuro- The Comprehensive Ophthalmology Ceremony oftalmologia (CLAN) held their XXIX Review Course on February 15–18, reunion at the UCLA Stein Eye Institute 2018, at the UCLA Stein Eye Institute, Residents, fellows, and faculty were on October 6–7, 2017. Spanish-speaking reviewed the clinical essentials of each honored for excellence at the Stein professionals and invited experts who subspecialty in ophthalmology. The Eye Institute/Doheny Eye Institute specialize in neuro-ophthalmology came course was clinically oriented, with graduation on June 1, 2018: together at CLAN to discuss complex review concentrating on the epidemi- issues and clinical cases. The event was ology, clinical presentation, diagnosis, Resident Research Award co-coordinated by Peter A. Quiros, MD. and management of ophthalmologic Tamara Lenis, MD, PhD Invited Speaker, Joseph L. Demer, disease to prepare attendees for upcom- Clinical Fellow Research Award MD, PhD, spoke about the contribu- ing ophthalmology examinations and tions of orbital connective tissues and required continuing medical education Deepak Ramesh, MD extraocular muscle compartmentaliza- recertification. International Fellow tion to ocular motility and strabismus. Directed by Drs. John A. Irvine and Research Award UCLA Department of Ophthalmology Sherwin J. Isenberg, the 4-day inten- Ji Hyun Kim, MD faculty Drs. Anthony C. Arnold, Laura sive review course is held annually by Bonelli, Lynn K. Gordon, Stacy L. the UCLA Stein Eye and Doheny Eye Predoctoral Fellow Pineles, and Alfredo A. Sadun contrib- Institutes. UCLA Course Faculty con- Research Award uted to the two-day program, as did vol- tributing to the 2018 program were Roni Hazim unteer faculty member Dr. Howard R. Drs. Bruce B. Becker, Benjamin B. Krauss and neuro-ophthalmology clini- Bert, Hugo Y. Hsu, Alex A. Huang, Postdoctoral Fellow cal fellow alumnus Dr. Melinda Chang. Monica R. Khitri, Olivia L. Lee, Colin Research Award A. McCannel, Tara A. McCannel, Soh Youn Suh, MD Basic and Advanced Training Kevin M. Miller, Daniel B. Rootman, SriniVas R. Sadda, David Sarraf, Irena ARVO Young Investigator in Cataract Surgery Tsui, and Federico G. Velez. Travel Award Dr. Kevin M. Miller, chief of the Cataract Todd Driver, MD and Refractive Surgery Division, orga- International Retinal Imaging nized two cataract surgery courses, Symposium and Case Resident Weekly Quiz Award which included instruction by Drs. Cameron Pole, MD Saba Al-Hashimi, John D. Bartlett, Conference Resident Award for Medical Hugo Y. Hsu, Kenneth L. Lu, Colin A. The International Retinal Imaging Sym- Student Teaching McCannel, Bartly J. Mondino, and the posium (IntRIS) held at the California valuable contributions of UCLA volun- Todd H. Driver, MD Nano-Systems Institute at UCLA on teer faculty members. Wade Stoddard, MD February 20, 2018, featured lectures The J&J Vision Basic Cataract Sur- in retinal imaging, including adaptive Resident Teaching Award gery Course in Santa Ana, California, optics, fundus auto fluorescence, ultra- Todd H. Driver, MD on October 21, 2017, included all steps wide field imaging, spectral domain and of cataract surgery from obtaining swept source optical coherence tomog- Fellow Teaching Award informed consent through postopera- raphy (OCT), and OCT angiography. Christopher C. Lo, MD tive instructions. In addition, afternoon Directed by Drs. David Sarraf, skills-transfer laboratories provided K. Bailey Freund, and SriniVas R. Faculty Teaching Award attendees with hands-on experience. Sadda, IntRIS was a joint presentation Monica R. Khitri, MD The Bausch & Lomb Advanced Cat- by the UCLA Stein Eye and Doheny aract Surgery course, May 5, 2018, in Eye Institutes and featured worldwide Irvine, California, presented an anterior experts as guest speakers. and pars plana vitrectomy wet lab, an The Doheny/Stein Case Conference affiliated technologies dry lab, and a that followed on February 21, 2018, complex case video workshop. reviewed case presentations demon- For information about upcoming cat- strating diagnostic and/or management aract courses, contact Dr. Miller at (310) dilemmas. 206-9951 or by email: kmiller@ ucla.edu.

12 Stein Eye Institute | A Year in Review 23rd Annual Vision Science Conference The Vision Science Conference, jointly sponsored by the Stein Eye Institute and the National Eye Institute Vision Science Training Grant, celebrated its twenty-third year October 13–15, 2017, at the UCLA Lake Arrowhead Confer- ence Center. Basic scientists, clinical researchers, pre- and postdoctoral fellows, and invited guests participated in discussions and learning activities related to vision-science research. Dr. Gustavo Aguirre, professor of medical genetics and ophthalmology at the Uni- versity of Pennsylvania, presented the keynote address.

UCLA Orbital Center Master’s Symposium and Dissection Workshop UCLA Department of Ophthalmology Clinical and Research Seminar The UCLA Orbital Center Master’s Symposium and Dissection Workshop The Institute’s most prestigious edu- 16TH THOMAS H. PETTIT LECTURER February 23–24, 2018, at the UCLA Stein cational event, the UCLA Depart- David S. Rootman, MD Eye Institute, was a tightly focused pro- ment of Ophthalmology Clinical and Professor of Ophthalmology gram of techniques and concepts related Research Seminar, was held June and Visual Sciences to orbital disease and its management. 8–9, 2018, at the UCLA Stein Eye University of Toronto Targeted to practicing ophthalmolo- Institute. gists and orbital surgeons, the workshop The seminar covered current clin- 16TH BRADLEY R. STRAATSMA focused on practical techniques and ical and research aspects of each of LECTURER conceptual pearls that participants could the ophthalmic sub-specialties, and Vinit B. Mahajan, MD, PhD immediately apply to their own practice. included the full-time faculties of Associate Professor of Ophthalmology Dr. Dinesh Selva, foundation chair the Stein Eye and Doheny Eye Insti- Stanford University of ophthalmology at the University of tutes, along with nationally promi- Adelaide, Australia, presented The Jack nent invited lecturers. 49TH JULES STEIN LECTURER Rootman Lectureship in Orbital Disease. Sessions addressed current best Carol L. Shields, MD Program Chairs Drs. Daniel Rootman practices in management, advanced Professor and Director and Robert Alan Goldberg, chief of the surgical techniques, latest diagnos- Ocular Oncology Service Orbital and Ophthalmic Plastic Surgery tic technology, and translational Wills Eye Hospital Division, oversaw the program, which research, in multiple educational was taught by a multidisciplinary faculty formats, including didactic lecture, 49TH DOHENY MEMORIAL of renowned leaders in the field. panel discussion, and case-based LECTURER interactive presentations. Stephen D. McLeod, MD The annual seminar also included Professor and Chair keynote lectures. Department of Ophthalmology University of California, San Francisco

A Year in Review | Stein Eye Institute 13 Ophthalmology Basic and Study Groups Clinical Science Course Regular study group meetings are an The Ophthalmology Basic and Clinical integral part of the Stein Eye residency Science Course is designed for ophthal- and clinical fellowship training pro- mology residents and also serves as a grams, and they also serve as an infor- review course for ophthalmologists. mal resource for practicing ophthalmol- In 2017–2018, the following course ogists in the community. components were offered under the Cornea Conference direction of Course Chairman, Bartly J. Mondino, MD. Coordinator: Anthony J. Aldave, MD

Fundamentals and Principles of Glaucoma Conference Ophthalmology Coordinator: Joseph Caprioli, MD Daniel B. Rootman, MD, MS Neuro-Ophthalmology Conference September 6, 2017–September 27, 2017 Coordinator: Anthony C. Arnold, MD Pathology Oculoplastics Conference Ben J. Glasgow, MD Coordinator: Robert Alan Goldberg, MD October 4, 2017–October 25, 2017 Ophthalmic Pathology Conference Orbit, Eyelids, and Lacrimal System Coordinator: Ben J. Glasgow, MD Robert Alan Goldberg, MD November 1, 2017–December 20, 2017 Pediatric Ophthalmology and Strabismus Conference External Disease and Cornea Coordinators: Sherwin J. Isenberg, MD, Anthony J. Aldave, MD Federico Valez, MD, and January 10, 2018–February 21, 2018 Joseph L. Demer, MD, PhD Refractive Surgery Pediatric Rheumatology and David Rex Hamilton, MD, FACS Uveitis Conference February 28, 2018–March 7, 2018 Coordinator: Gary N. Holland, MD Lens and Cataract Retinal Imaging Conference Kevin M. Miller, MD Coordinators: Steven D. Schwartz, March 21, 2018–April 18, 2018 MD, and other members of the Retina Glaucoma Division Joseph Caprioli, MD April 25, 2018–June 6, 2018 Vision Science Seminar Series The seminar series, coordinated by Ophthalmology Clinical Conferences, Drs. Sophie X. Deng and David S. coordinated by Drs. Anthony C. Arnold Williams, is conducted throughout and Gary N. Holland, are offered in con- the academic year and allows faculty junction with the weekly Ophthalmology to present their research to colleagues. Basic and Clinical Science Course. The series often includes presentations The conferences review patient care by eminent visitors to the Stein Eye activities of the UCLA Department of Institute vision-science campus. Ophthalmology, present topics in ophthalmic science, and promote discussion of relevant aspects of ophthalmic pathology and pharmacy.

14 Stein Eye Institute | A Year in Review Community Outreach

Access to a Cure Learn More at the UMEC Website is Access to Care Privately funded, the UMEC has been providing free eye care services and The UCLA Mobile Eye Clinic (UMEC) glasses for underserved communities achieved extraordinary numbers this in Los Angeles County for over 40 years 2017–2018 academic year: 17,642 chil- and has been honored for exemplary dren and adults were served, 2,224 leadership in shaping the future of health ocular abnormalities were diagnosed, care. and 789 trips were made throughout Preschool Vision Program Go to uclahealth.org/mobile-eye- Los Angeles County. In addition, the clinic to find dates, times, and locations The UCLA Preschool Vision Stein Eye Institute’s community out- of upcoming UMEC clinics; listings of Program offered no-cost reach activities included the following: low-income clinics in the Los Angeles services for underserved community; and organizations aligned preschoolers in the Los Adult Vision Program with the UMEC’s mission to provide Angeles area and provided: Through the Adult Vision Program, 1,343 vision services at low or no cost to ff14,861 vision screenings free eye exams were given to individ- the most vulnerable members of our uals lacking access to adequate vision community. ff1,903 fully dilated eye exams care due to reasons such as cost, trans- ff1,630 pairs of eyeglasses portation, and insurance. The program provided 133 adult community-outreach ff443 referrals for partner events at homeless shelters, libraries, specialists for preschool federally qualified health centers, and students needing other nonprofits in the Los Angeles Below: Ken Kitayama, a UCLA medical specialized medical or County area. student volunteering at the November 2017 surgical treatments. Care Harbor free clinic, uses an FDT Matrix visual field machine to determine if a patient Health Fairs is experiencing any visual field loss. The UMEC attended five health fairs, saw 141 patients, and gave 29 referrals to individuals who needed follow-up care.

Care Harbor 2017 Continuing its annual tradition, the UMEC participated in Care Harbor Los Angeles, November 17–19, 2017, where 2,151 of the community’s most vulnerable patients received free medical, dental, vision, and preventive care con- servatively valued at $2,110,000. At the three-day event, 16 ophthalmologists, and over 20 nurses, tech- nicians, and support staff volunteered their time and evaluated 233 patients. Comprehensive dilated exams were given to patients at risk for eye disease, which would include a history of diabetes or hypertension, a family history of glaucoma, or decreased vision not corrected with eyeglasses, and 187 patients were referred to community eye specialists for further evaluation and treatment, which is often given free of charge.

A Year in Review | Stein Eye Institute 15 Alumni

Alumni News 90 publications and invited lectures throughout the world. David H. Aizuss, MD, resident alumnus Dr. Kokame is also a co-founder of (1981–1984) and assistant clinical pro- the Gass Fellowship Society, which cel- fessor of ophthalmology, was honored ebrated its 7th meeting in New Orleans, with the Independent Physician Lead- Louisiana, on November 9, 2017. ership Award in Los Angeles, California, on November 1, 2017. AAO Stein Resident alumnus Harry S. Brown, and Doheny Alumni MD, FACS, (1967–1970), posthumously Stein and Doheny Host received the 2018 Biosyntrx Thornton Reception in Joint Alumni Reception Humanitarian Award for his humanitarian New Orleans spirit and relentless passion to restore UCLA Stein Eye and Doheny Eye Insti- sight to nearly a half million people tute faculty members, along with res- through Surgical Eye Expeditions (SEE) ident and fellow alumni from around International. Dr. Brown founded the the world, gathered in New Orleans nonprofit organization over 40 years ago on November 12, 2017, for the UCLA to offer medical services by volunteer Stein Eye Institute Alumni Association ophthalmic surgeons to disadvantaged and Doheny Eye Institute Professional patients worldwide. Alumni Association’s reception. The The award was presented to SEE in annual gathering provided an opportu- Dr. Brown’s honor at the Hawaiian Eye nity for alumni from various graduating Foundation event in Wailea, Hawaii, on classes to reconnect with colleagues January 15, 2018. and classmates.

Find more photos at: www.facebook. John So-Min Chang, MD, resident com/JSEIAlumni/. Drs. Anne Coleman, Bartly Mondino, and George alumnus (1987–1990), has been named Rajacich join Marissa Goldberg, chief operating officer of the Doheny Eye Institute. president-elect of the International Society of Refractive Surgery. Drs. Stacy Pineles, Erika Tanaka, Victoria Tseng, Mitra Nejad, David B. Cohen, MD, PC, resident Grant Moore, alumnus (1989–1992), died September Juliet Essilfie, and 26, 2017, at the age of 55, following Dr. Robert Goldberg at the 2017 alumni four years of neurological complications reception. associated with radical neck surgery.

Gregg T. Kokame, MD, resident alumnus (1984–1987) and 2014 Pettit Lecturer, celebrated the 25th anniver- sary of The Retina Center at Pali Momi, with an international vitreoretinal symposium April 27–29, 2018, in Waikiki, Hawaii. Dr. Kokame founded The Retina Center in 1993—the same year as his clinical practice, Retina Consultants of Hawaii—and is its medical director of research and educational programs. The Retina Center at Pali Momi has participated in over 50 multicenter clini- Drs. Howard Krauss, Kamal Zakka, and cal trials, with research resulting in over Colin McCannel with Dr. J. Bronwyn Bateman. Drs. Jonathan Braun and Alexander Khammar share a light-hearted moment.

16 Stein Eye Institute | A Year in Review JSEI Affiliates

JSEI Affiliates ff The MagniVision program provides ff The Shared Vision program col- Share the Gift of Sight financial support for the UCLA Vision lected and recycled approximately Rehabilitation Center (VRC), which 2,600 donated eyeglasses for those The JSEI Affiliates, the volunteer arm enables the purchase of low-vision in need. Recycled eyeglasses were of the Stein Eye Institute established tools for the VRC lending library. This cleaned, tagged with the vision in 1990, accomplished impressive year, under the direction of JSEI Affil- correction, and distributed to Los community outreach results this fiscal iates Advisory Board Member Robin Angeles homeless shelters, as well year—results that would not have been Carnesale, the Amazon Echo Dot and as clinic missions conducted by possible without the commitment of Kindle Fire devices were added to nonprofit groups in Africa, Central generous members and donors and the library. Low-vision patients may America, and other low-resource the dedication of over 143 volunteers. borrow the voice-activated assistive regions. ff The Vision IN-School (VIS) educa- devices for an indefinite period of time. ff Team Stein Eye participated in the tion program is offered free of charge eleventh annual Los Angeles Foun- to fourth- through seventh-grade pub- ff The Preschool Vision Screening dation Fighting Blindness Vision lic school students in Los Angeles. program began 18 years ago with the Walk, which was held at Woodley Students are taught about the anat- inspiration and support of Mrs. Glorya Park on October 21, 2017. The event, omy of the eye, eye safety, and injury Kaufman and under the supervision supported by both Stein Eye Institute prevention. The highlight of each of the late Dr. Leonard Apt, found- employees and volunteers from the in-class presentation is a hands-on ing chief of the Division of Pediatric JSEI Affiliates, raised funds for retinal dissection of a bovine eye. Thirty- Ophthalmology and Strabismus. eye disease research. three VIS volunteers visited 18 class- During the 2017–2018 school year, rooms this past year, presenting 44 JSEI Affiliates volunteers visited the curriculum to 579 elementary 32 preschools to screen 789 children students. between three and five years of age. ff Two successful sponsorship drives were held this year for the Make Surgery Bearable program, an initiative that provides Dr. Teddy bears to each pediatric patient undergoing eye surgery at the Stein Eye Institute. This past year, the Affiliates intro- duced a bigger, cuddlier bear dressed in green scrubs and tagged with the name of the donor to help children feel comforted and secure during what could otherwise be a frighten- ing time. UCLA Bruin Belle volunteers joined forces with the Affiliates to help tag the bears. The informational children’s book, Making Eye Surgery Bearable, helps pediatric patients and parents prepare for their surgery at the Stein Eye Institute. Offered in both Spanish and English, the book was written at the suggestion of the Pediatric Ophthalmology and Strabismus Division.

A Year in Review | Stein Eye Institute 17 Philanthropy

A LEGACY FOR LOVED ONES

s a young resident at Stein Eye, Dr. Bronwyn Bateman was in the early stages of a brilliant career when tragedy struck. Her late Ahusband, Roderick K. Smith, who was an orthopedic resident at UCLA, was diagnosed with mesothelioma, an asbestos-related cancer, and passed away after an 11-month battle with the disease.

This could have derailed her career, but her Stein Eye advisor, Dr. Bradley Straatsma, made sure Dr. Bateman had the support needed to stay on track. “He called me in,” Dr. Bateman recalls, “and asked what I wanted to do with my life, and I said I didn’t know. He suggested ophthalmic genetics. This was before DNA was really harnessed to identify gene defects in hereditary diseases. I said yes.” Dr. Bateman took the Boards in both Ophthalmology and Medical Genetics/Clinical Genetics. “I was able to have one foot in ophthalmology and one foot in medical genetics,” she explains. “Looking back, the professional opportunities offered by Dr. Straatsma and Dr. Bartly Mondino, director of the UCLA Stein Eye Institute Dr. Bronwyn Bateman and chairman of the UCLA Department of Ophthalmology, were pivotal in my career.” The key is creating a BREAKING THE GLASS CEILING—Dr. Bateman segued into a faculty legacy at a quality position at Stein Eye, and also became the first woman president of the institution that has a high American Association of University Professors, the organization for chairs of ophthalmology in the U.S. and Canada, and the president of the Pan level of integrity, and I American Association of Ophthalmology, strengthening ties with Latin think there is opportunity American colleagues, many of whom are Stein Eye alumni. for people to do very nice things for their family here GIVING FOR SOMEONE WHO COULD NOT—“I thought about a gift to benefit Stein Eye for a long time. I wanted to honor my first husband, who at UCLA. was not able to have a life and career. By endowing a chair in his name, I DR. BRONWYN BATEMAN gave him the legacy that he could not create.”

With this in place, funded through an outright gift of cash and an additional future gift, pledged through her estate, Dr. Bateman is now focusing on further structuring her estate in a tax-sensible manner to fund an endowed chair named after her mother and grandmother. “My grandmother was a Norwegian farm girl who married a physician. She used to say ‘you better study otherwise you’re going to end up on a farm,’“ Dr. Bateman laughs. “My mother graduated from medical school in 1941 and became a pediatrician while my father was busy with the U.S. military in the Pacific theater. She managed to work full-time and raise five children.”

Not one to forget kindness, Dr. Bateman also plans to create a “nurses travel fund” in honor of nurses Nan Fulton, Sue Yamada, and Leonore Vogel who were especially caring and helpful while she was dealing with her husband’s health and his passing.

18 Stein Eye Institute | A Year in Review Thank You

or more than 50 years, the Stein Eye Institute at UCLA has joined Fwith devoted donors to carry forward our mission to preserve sight and restore vision. We are tremendously grateful for the commitment our supporters have provided for vital research, education, patient-care, and community-outreach pursuits. Such an investment has a powerful and positive impact on ophthalmology and related disciplines locally, nationally, and worldwide, for which we remain enduringly thankful.

A Year in Review | Stein Eye Institute 19 Major Gifts $25,000 and above: Albert Sarnoff Bert O. Levy Kotick Family Foundation Bradley R. Straatsma, MD, JD Bruce Ford and Anne Smith Bundy Foundation Carol and Timothy W. Hannemann Dr. Peter F. Mason Elaine Sarkaria Estate of Jean Stein Fairchild-Martindale Foundation Frederic G. Rappaport Trust Heidelberg Engineering GMBH Heidelberg Engineering, Inc. Hongbin Peng J. Bronwyn Bateman, MD Jan K. Takasugi, MD, and Robert A. Goldberg, MD Jerome and Joan Snyder Joan A. Payden and William R. Payden Jules and Doris Stein UCLA Support Group Karen and Franklin Dabby Lavery Foundation Lin Hsiung Chen Memorial Scholarship Foundation Louis and Annette Kaufman Family Trust Michael J. Groth, MD, and Ileana E. Zapatero, MD Nancy and Allen Kramer Patricia M. and Wayne T. Clemensen Peter and Helen Bing Research to Prevent Blindness, Inc. Ruth and George E. Moss Smidt Family Foundation The Carl and Roberta Deutsch Foundation The Foundation Fighting Blindness The Karl Kirchgessner Foundation The Simms/Mann Family Foundation The Vision of Children Foundation, Sam Hardage and Vivian Hardage The William & Margaret Fern Holmes Family Foundation Theo and Wendy Kolokotrones Tony and Marilyn Rossi Family Trust–1992 VHL Alliance Wilbur May Foundation Individuals Recognized Stein Eye Institute Endowed Dolly Green Chair of with a Tribute Gift Chairs Supporting Department Ophthalmology of Ophthalmology Faculty Established in 1980 by Ms. Dorothy (Dolly) Green. IN HONOR OF: The Ahmanson Braddock–Andrews Family Dean Bok, PhD Chair in Ophthalmology 1984–2013 Dr. Dean Bok Established in 2006 by The Ahmanson Dr. Joseph Caprioli Foundation as an administrative chair Ernest G. Herman Dr. Richard Casey for the Retina Division Chief to further Chair in Ophthalmology research, education, and clinical care Established in 2008 by Mr. Ernest G. Dr. Joseph L. Demer programs. Herman to support a vision scientist or Mr. Robert J. Drabkin Steven D. Schwartz, MD a clinician-investigator. Dr. Robert A. Goldberg 2007–Present Xian-Jie Yang, PhD Dr. Michael B. Gorin 2012–Present Leonard Apt Endowed Mary Lou Harnden Chair in Pediatric Ophthalmology Karl Kirchgessner Foundation Mrs. Karyn Jackson Established in 2004 by Professor Emer- Chair in Vision Science Jennie Kageyama, OD itus of Ophthalmology and Founding Established in 2001 as a term chair by a Director of the Division of Pediatric Oph- colleague of Dr. Jules Stein to promote Dr. Allan E. Kreiger thalmology and Strabismus, Dr. Leonard basic-science research initiatives. Debra Lauer Apt, with a gift from the trust of Frederic Debora B. Farber, PhD, DPhhc Mr. David A. Leveton G. Rappaport, Dr. Apt’s nephew. 2001–2018 Ken Matsumoto Joseph L. Demer, MD, PhD Dr. Kevin M. Miller 2005–2015 Kolokotrones Chair in Ophthalmology Dr. Steven D. Schwartz Karen and Frank Dabby Established in 2004 by Wendy and Theo Dr. Bradley R. Straatsma Endowed Chair in Ophthalmology Kolokotrones to support the teaching Lon Tinney Established in 2007 by Dr. and Mrs. and research of a cataract surgeon and Dabby as a term chair to support the scientist. Patricia Tussing activities of a distinguished faculty mem- Kevin M. Miller, MD ber in the area of orbital disease. 2005–Present IN MEMORY OF: Robert Alan Goldberg, MD Dr. Leonard Apt 2008–2018 Grace and Walter Lantz Bob Artechevarria Endowed Chair in Ophthalmology Charles Kenneth Feldman Established in 1991 as a term chair by Pat Busch Chair in Ophthalmology Mr. and Mrs. Lantz and, with an addi- Duane Carter Established in 1982 by various donors in tional pledge, it was converted to a Mr. Edward C. Cazier, Jr. memory of Charles Kenneth Feldman, permanent-appointment chair in 2010. an entertainment industry executive. Donald M. Fetherolf J. Bronwyn Bateman, MD Robert D. Yee, MD Janet Freeman Grace and Walter Lantz Scholar Professor 1984–1987 1993–1995 Ms. Peggy L. Giambrocco Hillel Lewis, MD Dr. Herbert J. Grossman Sherwin J. Isenberg, MD Scholar 1989–1993 Grace and Walter Lantz Scholar Jeanette M. Gunn 1993–1995 Gabriel H. Travis, MD Chad J. Holman Professor 1996–2004 2001–Present Kenya Jamal Joseph L. Demer, MD, PhD Ms. Ione J. Kanne Laraine and David Gerber Professor 2004–2005 Dr. Ralph Kustoff Chair in Ophthalmology Established in 1998 as a term chair Walton Li Chair in Cornea Joseph S. Mancuso by Mr. and Mrs. Gerber and, with and Uveitis Paul H. Orlopp an additional pledge, converted to a Established in 2013 by Walton W. Li, Judy Page permanent-appointment chair in 2009. MD, as an administrative chair for the Cornea and Uveitis Division to further Mr. Stanley K. Rothstein Joseph L. Demer, MD, PhD 2000–2004 research and teaching activities. Rose Silkiss Anthony J. Aldave, MD Sherwin J. Isenberg, MD Pat Stel 2014–Present 2004–Present Ruth Straatsma

A Year in Review | Stein Eye Institute 21 David May II Chair in Jack H. Skirball Chair in Ocular Jules Stein Chair in Ophthalmology Inflammatory Diseases Ophthalmology Established in 1998 as a term chair by Initiated in 2008 by The Skirball Foun- Established in 1982 as a memorial the family of Mr. David May II, a found- dation in honor of Jack H. Skirball’s tribute to Dr. Jules Stein by his many ing member of the Institute’s Board of long-standing friendship with Dr. Jules friends, with the leadership of Mr. Trustees, to perpetuate, in memoriam, Stein and Lew Wasserman. Samuel Goldwyn, Jr. Mr. May’s association with the Stein Gary N. Holland, MD Wayne L. Hubbell, PhD Eye Institute; after an additional pledge 2009–Present 1983–Present from the Wilbur May Foundation, it was converted to a permanent-appointment Smotrich Family Optometric Bradley R. Straatsma, MD, chair in 2009. Clinician-Scientist Chair Endowed Chair in Ophthalmology Gary N. Holland, MD Established in 2016 to support an opto- Established in 1994 to honor found- 1999–2004 metric clinician-scientist at the UCLA ing director of the Stein Eye Institute, Stein Eye Institute and will fund the Bradley R. Straatsma, MD, JD. Joseph Caprioli, MD appointee’s education and research Bartly J. Mondino, MD 2004–Present programs. 2000–Present

Mary Oakley Foundation Jerome and Joan Snyder Chair in Vernon O. Underwood Family Chair in Neurodegenerative Ophthalmology Chair in Ophthalmology Diseases Established in 2008 by Mr. and Mrs. Established in 1995 as a term chair by Established in 2013 by The Mary Oakley Snyder to support the activities of a dis- Mrs. Adrienne Underwood Pingree in Foundation to support neurodegenera- tinguished faculty member who directs memory of her late husband, Mr. Vernon tive diseases. the ophthalmology residency program, O. Underwood. Anthony C. Arnold, MD ensuring that UCLA’s accredited pro- John R. Heckenlively, MD 2017–Present gram continues to offer rigorous and 1997–2004 comprehensive instruction for individ- Oppenheimer Brothers Chair uals of the highest caliber. Gary N. Holland, MD Established in 2002 as a term chair by Anthony C. Arnold, MD 2004–2009 the Oppenheimer Brothers Foundation. 2008–2017 Joseph Horwitz, PhD Lynn K. Gordon, MD, PhD 2003–2017 Stacy L. Pineles, MD 2012–Present 2017–Present Harold and Pauline Price Chair in The Wasserman Professor of Ophthalmology Joan and Jerome Snyder Chair in Ophthalmology Established in 2000 by the Louis and Cornea Diseases Established in 1977 by Edie and Lew Harold Price Foundation and, with an Established in 2013 by Mr. and Mrs. Wasserman to honor Dr. Jules Stein. additional pledge, it was converted to a Snyder to support the activities of a Manfred Spitznas, MD permanent-appointment chair in 2006. distinguished faculty member in the 1979–1981 area of corneal diseases and research. Michael B. Gorin, MD, PhD Bartly J. Mondino, MD 2006–Present Scholar 1984–1988 The Fran and Ray Stark Professor 1988–2000 Arthur L. Rosenbaum, MD, Chair Foundation Chair in in Pediatric Ophthalmology Ophthalmology Ben J. Glasgow, MD Established in 2007 by Mr. and Mrs. Established in 1992 as a term chair by 2003–Present Gottlieb as an administrative chair for the the Fran and Ray Stark Foundation, and Division of Pediatric Ophthalmology and with an additional commitment, it was Strabismus in honor of the late Dr. Arthur converted to a permanent-appointment L. Rosenbaum. The chair was originally chair in 2009. named the Brindell and Milton Gottlieb Joseph Caprioli, MD Chair in Pediatric Ophthalmology. 1997–2004 Arthur L. Rosenbaum, MD Anne L. Coleman, MD, PhD 2008–June 2010 2004–Present Joseph L. Demer, MD, PhD 2015–Present

22 Stein Eye Institute | A Year in Review Doheny Eye Institute Endowed Stein Eye Institute Fellowship Frances Howard Goldwyn Chairs Supporting Department Funds and Endowments Fellowship of Ophthalmology Faculty Established in 1977 by Mr. Samuel Rosalind W. Alcott Fellowship Goldwyn, Jr., with gifts from Mrs. Stephen J. Ryan-Arnold and Established in 1978 by the Rosalind W. Goldwyn’s estate and Dr. and Mrs. Mabel Beckman Foundation Alcott Charitable Remainder Trust for Jules Stein. Endowed Presidential Chair the training of outstanding postdoctoral Bora Chae, MD SriniVas R. Sadda, MD fellows. 2016–2017 2015–Present Laura A. Vickers, MD, MA 2016–2017 Elsa and Louis Kelton Fellowship Rupert and Gertrude I. Stieger Endowed by the Keltons in 1982 to sup- Vision Research Chair Leonard Apt Endowed Fellowship port postdoctoral research and training. Brian A. Francis, MD, MS in Pediatric Ophthalmology Aaron Nagiel, MD, PhD 2015–Present Established in 2002 by founding chief 2015–2016 of the Pediatric Ophthalmology and An Huynh, MD Flora L. Thornton Endowed Strabismus Division, Leonard Apt, MD, 2016–2017 Chair in Vision Research to support outstanding clinical fellows in the field of pediatric ophthalmology Alfredo A. Sadun, MD, PhD Jerome Comet Klein, MD, and strabismus. 2014–Present Fellowship Fund Rui Zhang, MD Established in 2007 by the Irving & 2016–2017 A. Ray Irvine, Jr. MD, Estelle Levy Foundation to provide fel- Chair in Clinical Ophthalmology lowship and lecture support in the areas Leonard Apt, MD, Pediatric John A. Irvine, MD of orbital and ophthalmic plastic surgery. Fellowship Fund 2014–Present Wenjing Liu, MD Established in 2015 by the trust of 2016–2017 Mary D. Allen Chair in Leonard Apt, MD, founding chief of the Vision Research Pediatric Ophthalmology and Strabismus Bert Levy Research Fellowship Division, to support pediatric ophthal- Deming Sun, MD Fund mology fellowships. 2015–Present Established in 1995 by Mr. Bert Levy to enhance the educational opportunities Thelma and William Brand Gavin S. Herbert Endowed of vision science scholars and advance Director’s Fund Chair for Macular Degeneration research in neuro-ophthalmology. Established in 2004 with a trust from Mr. William F. Brand to benefit worthy Charles Stewart Warren and David May II Fellowship Fund Hildegard Warren students at the Stein Eye Institute. Established in 1992 by the family of Endowed Research Chair Mr. David May II to support advanced Vikas Chopra, MD Cooperman Fellowship Fund study and research in ophthalmology 2017–present Established in 1988 by the Coopermans and vision science. to support eye research and education, Sanket U. Shah, MD with emphasis on clinical ophthalmology. 2016–2017 Melinda Y. Chang, MD 2016–2017 Wilbur D. May Fellowship Established in 2013 by the May family David and Randi Fett Orbital and Ophthalmic Plastic Surgery as a tribute to Mr. Wilbur D. May, the Fellowship Endowment beloved uncle of Mr. David May II. Established in 2013 by Dr. David R. Fett and Ms. Randi Levine to support fellows John and Theiline McCone Fellowship in the Orbital and Ophthalmic Plastic Surgery Division. Established in 1989 by the McCones Sathyadeepak Ramesh, MD to support and enhance education pro- 2016–2017 grams and fellowship training in macular disease. Klara Spinks Fleming Fellowship Robert Arthur Lalane III, MD Fund 2016–2017 Established in 1985 by Klara Spinks Christian J. Sanfilippo, MD Fleming to support cataract research. 2016–2017 David T. Truong, MD 2016–2017

A Year in Review | Stein Eye Institute 23 Abe Meyer Memorial Fellowship Jules Stein Research Fellowship Jerome T. Pearlman, MD, Fund Fund Established in 1982 by various donors to John and Theiline McCone Macular Established in 1969 by various donors to honor the memory of Charles Kenneth Disease Research Fund support clinical fellows at the Institute. Feldman. David T. Truong, MD Aaron Nagiel, MD, PhD JSEI Maintenance Fund 2016–2017 2016–2017 Katherine L. Gardner Research Fund Adelaide Stein Miller Research Louis and Annette Kaufman Fund Fellowship Endowments for Research, Maggi Kelly Vision Fund Established in 1977 by Mr. Charles Miller Education, and Patient Care as a tribute to his wife, Adelaide Stein Albert Sarnoff Endowed Cataract Marie and Jerry Hornstein Family Miller, Dr. Jules Stein’s sister. Fund Endowed Macular Degeneration Nathaniel C. Sears, MD Research Fund 2016–2017 Amalia Simon Roth Endowment Michael Huffington Ophthalmology Anne H. West Estate Fund Scholarship Fund The Harold and Pauline Price Fellowship Anthony Eannelli Fund Pat and Joe Yzurdiaga Endowed Established in 1987 by the Louis and Arna Saphier Macular Degeneration Cataract Fund Harold Price Foundation to support Fund Patricia and Joseph Yzurdiaga research and education in ophthalmol- Endowed Vision Science Research ogy and vision care. Arthur Spitzer Fund Fund Laura A. Vickers, MD, MA Audrey Hayden-Gradle Trust 2016–2017 Patricia Pearl Morrison Research Fund Barbara P. Taylor Fund Paul J. Vicari Endowed Cataract Frederic G. Rappaport Endowed Bradley R. Straatsma Research Fund Fellowship in Retina/Oncology Research Fund Established in 2004 by Mrs. Jeanne Card Family Research Fund Raymond and Ruth Stotter Vision A. Rappaport as a memorial to her son Chesley Jack Mills Trust Science Research Fund Frederic. Daniel B. Whipple Fund Richard B. Shapiro Vision Fund Dr. Jack Rubin Memorial Dr. William F. Stein and Esther Sara Kolb Memorial Fund Fellowship Elizabeth Stein Memorial Fund Stella F. Joseph Fund Established in 1987 by the family of Dr. Jack Rubin to support postdoctoral Edward and Hannah Carter Fund The Annenberg Foundation Fund fellows. Elsie B. Ballantyne Regents Fund The Karl Kirchgessner Foundation Nathaniel Sears, MD Ophthalmology Endowment Fund 2016–2017 Elsie B. Ballantyne UCLA Foundation Fund The Leonard Apt, MD, Pediatric Sanford and Erna Schulhofer Emily G. Plumb Estate and Trust EyeSTAR Residency Training Fund Fellowship Fund Established in 1986 by Mr. Sanford Emma B. Gillespie Fund The Leonard Apt, MD, Pediatric Schulhofer to support postdoctoral Ophthalmology Fund Endowment for Children with Uveitis research and training in vision science. The Skirball Foundation Fund Bora Chae, MD Esther Shandler Research Fund 2016–2017 UCLA Center for Eye Epidemiology Gerald Oppenheimer Family Foundation Center for the Prevention Uncle Claude Fund The Mae and Lee Sherman of Eye Disease Endowment Fund Fellowship Fund Virginia Burns Oppenheimer Established in 1981 by the Sherman Harold B. and Bernice L. Belfer Fund Endowment Fund family to support postdoctoral fellows. Henry I. Baylis, MD, Endowed Fund Wickham Retina Research Fund Andrew Salem, MD in Orbital and Ophthalmic Plastic 2015–2016 William R. Payden Fund for Glaucoma Surgery Research Saba Al-Hashima, MD Herb Ritts, Jr., Memorial Vision Fund William, Richard, & Roger Meyer Fund 2016–2017 Herman King Fund Audrey and Jack Skirball Ocular Hintze Glaucoma Research Fund Inflammatory Disease Fellowship Established in 2011 by The Skirball J. Richard Armstrong and Foundation to support the training of Ardis Armstrong Fund fellows specializing in ocular inflammatory disease.

24 Stein Eye Institute | A Year in Review The legacy of Dr. and Mrs. Jules Stein arises from their role in the 20th century as visionaries. Through brilliance and beneficence, they created a multitude of programs aimed specifically at one goal: preserving and restoring eyesight. They approached this task dauntlessly, integrating the worlds of business, medicine, and philanthropy in such a way as to enhance each and leave in trust the promise of limitless accomplishment in the advancement of eye research and treatment. The Stein Eye Institute was established as a result of their philanthropy.

A Year in Review | Stein Eye Institute 25 Doris Stein Doris Stein’s purposeful, yet richly varied life, earned the respect and affection of the many people who benefited from her humanitarianism. Inspiring partner of her husband for more than half a century, Doris Stein shared with him the accomplishments of his philanthropic endeavors and guided his interests in ophthalmology, beginning with a visit to the New York Lighthouse for the Blind in the late 1950s. Deeply moved, Doris Stein urged her husband to “do some- thing!” From that passionate beginning came a broad base of programs that catalyzed eye research. Doris Stein was a major force in this vision renaissance. She served as an officer and director of Research to Pre- vent Blindness, personally leading the appeal to establish more resources for investigations into eye diseases. She suggested that Jules Stein assume the principal role in the creation of an eye Jules Stein institute at UCLA, and her unflagging Jules Stein is the foremost benefactor the entertainment industry. enthusiasm nurtured the Institute’s in the world history of vision science Throughout his phenomenally suc- development as a unique provider of and blindness prevention. He combined cessful career, Jules Stein maintained every facet of vision research and patient his love for music and medicine with a a strong interest and emotional invest- care. Serving as Trustee, she focused unique talent for analysis and organiza- ment in medicine, particularly his own special attention on Institute initiatives tion to produce a lifetime of celebrated field of ophthalmology. In the late 1950s, to combat blindness throughout the achievements as musician, physician, urged by his wife, Doris, he chose to world. She devoted her last days, until business leader, and humanitarian. direct his considerable talents to blind- her death in 1984, to the development Born in South Bend, Indiana, in 1896, ness prevention. The result was a con- of an expansion and companion building Jules Stein received a bachelor of phi- cert of ideas and achievements that for eye research. In 1989, dedication cer- losophy degree from the University of encompassed philanthropy, govern- emonies were held for the Doris Stein Chicago at age 18 followed by a medi- ment, and academic medicine. Eye Research Center. cal degree from Rush Medical College. By his efforts, Research to Prevent With grace, vision, and meaningful After completing postgraduate studies Blindness was created, now recog- action, Doris Stein enhanced the lives at the University of Vienna and Chicago’s nized as the world’s leading voluntary of all privileged to know her, stimulated Cook County Hospital, he began med- organization in support of studies of a cascade of progress in eye research, ical practice and was certified by the the eye and its diseases. Jules Stein co-founded the Institute with its bound- American Board of Ophthalmology. was largely responsible for the passage less scientific potential, and extended A musician from an early age, he of legislation to establish the National the miracle of sight to untold numbers financed his education by playing in and Eye Institute as a separate entity in the of people. leading his own band. As his reputation National Institutes of Health. Under his increased, he began booking other musi- leadership, the Stein Eye Institute was cians for professional engagements, and founded as a multidisciplinary center for in 1924, founded Music Corporation vision science. Since its establishment, of America (MCA). Shortly thereafter, the Institute has become internationally he gave up the practice of medicine to identified as the focus for coordinated concentrate on this enterprise. Within programs of research in the sciences 10 years, MCA represented most of the related to vision, ophthalmic education, great name bands and corporate activi- and the care of patients with eye dis- ties began to extend to representation of ease. Jules Stein died in 1981, leaving a film stars, directors, writers, and musi- legacy of hope to the world. Through his cal artists. MCA entered the promising accomplishments and philanthropy, he new field of television at its inception, created ever-replenishing resources for eventually acquiring the Universal City eye research and the means to preserve property, Universal Pictures, and other and restore sight for future generations. enterprises to become preeminent in

26 Stein Eye Institute | A Year in Review Board of Trustees

Board of Trustees, established in 1977, ensures the Institute’s orderly growth and development. The Board meets regularly during the year, with each Trustee providing his/her unique counsel. Collectively, their invaluable contributions have included fiscal planning for the Institute, adoption of measures to facilitate recruitment of the world’s finest vision scientists, allocation of funds for the purchase of vision research equipment, and recommendations for expansion programs.

Norman Abrams, Esq. Edward A. Landry, Bartly J. Mondino, MD Distinguished Professor Esq. Director of Law Emeritus Stein Eye Institute Partner Acting Chancellor Emeritus 1994–present Musick, Peeler & Garrett UCLA 2016–present 2015–present

Ronald L. Olson, Gerald H. Oppenheimer Nelson C. Rising, Esq. President, Gerald Oppenheimer Esq. Partner Family Foundation Chairman and Munger, Tolles & Olson President, Systems Design Chief Executive Officer 1995–present Associates Rising Realty Partners 1992–present 2011–present

Katrina vanden Casey Wasserman Observer Heuvel President and Chief Executive Marissa Goldberg Publisher and Editor Officer Executive Director and The Nation The Wasserman Foundation Chief Financial Officer 1984–present 1998–present Doheny Eye Institute 2015–present

A Year in Review | Stein Eye Institute 27 The Executive Committee

The Executive Committee of the Stein Eye Institute and UCLA Department of Ophthalmology meets regularly during the year, with each member providing their unique expertise. The Committee ensures the orderly growth and development of the Institute and Department. It is involved in fiscal planning, expansion, recruitment, program development, and resolution of interdivisional issues.

Bartly J. Mondino, MD Director, Stein Eye Institute Chairman, UCLA Department of Ophthalmology Affiliation Chairman, Doheny Eye Institute

Anthony C. Arnold, MD Vice Chairman, Education

Anne L. Coleman, MD, PhD Vice Chairman, UCLA Department of Ophthalmology

SriniVas R. Sadda, MD President and Chief Scientific Officer, Doheny Eye Institute

Alfredo A. Sadun, MD, PhD Vice Chairman, Doheny Eye Center UCLA

Alapakkam P. Sampath, PhD Associate Director, Stein Eye Institute

Jonathan D. Smith Chief Administrative Officer, Stein Eye Institute

Gabriel H. Travis, MD Special Advisor

28 Stein Eye Institute | A Year in Review The UCLA Stein Eye Institute is a vision-science campus dedicated to the preservation and restoration of vision through its global programs in innovative research, quality patient care, and multidisciplinary, integrative education, all with community outreach.

A Year in Review | Stein Eye Institute 29 30 Stein Eye Institute | A Year in Review Faculty Faculty

Anthony J. Aldave, MD Public Service Walton Li Chair in Cornea and Uveitis Associate Examiner, American Board of Ophthalmology Professor of Ophthalmology Chair, American Academy of Chief of the Cornea and Uveitis Division Ophthalmology Practicing Ophthalmologists Curriculum, Member of the Stein Eye Institute Cornea and External Disease Panel Chair, Cornea Society Scientific Program Committee Discovering the Genetic Basis of the Corneal Dystrophies Member, Cornea Society Board of Directors The Cornea Genetics Laboratory, under Dr. Aldave’s direction, is involved in Member, Eye Bank Association of identifying and elucidating the genetic basis of inherited corneal disorders, America Medical Advisory Board such as posterior polymorphous and Lisch corneal dystrophies. Member, Editorial Board, Cornea Member, Editorial Board, Molecular Vision Ad hoc member, NIH, Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section, 2016/10 NAME meeting Ad hoc member, NIH, Genetics of Health and Disease (GHD) Study Section, 2017/05 GHD meeting Reviewer for many scientific journals

32 Stein Eye Institute | Faculty Faculty

Saba Al-Hashimi, MD

Health Sciences Assistant Clinical Professor

Cornea, External Disease, and Refractive Surgery Specialist

Dr. Al-Hashimi is a clinician with a research interest in keratoconus and corneal crosslinking. His research focus involves halting the progression of corneal disease by using light and chemicals to strengthen the cornea. Specializing in infections of the cornea, Dr. Al-Hashimi performs surgical procedures that include corneal transplantation, Descemet membrane stripping endothelial keratoplasty, Descemet membrane endothelial keratoplasty, deep anteri- or lamellar keratoplasty, corneal patch grafts, pterygium surgery, corneal repair, cataract surgery, and premium cataract surgery with femtosecond laser. Patients can see “Dr. Saba” at the UCLA Stein Eye Institute.

Faculty | Stein Eye Institute 33 Faculty

Anthony C. Arnold, MD Public Service Mary Oakley Foundation Chair in Neurodegenerative Diseases Faculty, Stanford/Bay Area Basic Science Course in Professor of Clinical Ophthalmology Neuro‑Ophthalmology Chief of the Neuro-Ophthalmology Division Faculty, Lancaster Course in Ophthalmology, Colby College Director of the UCLA Optic Neuropathy Center Board Director, American Vice Chairman, Education Board of Ophthalmology Member of the Stein Eye Institute Chair, ACGME Residency Review Committee for Ophthalmology Chair, ACGME Milestones Committee Ischemic and Inflammatory Diseases of the Optic Nerve for Ophthalmology Reviewer for many scientific journals Dr. Arnold directs a neuro-ophthalmol Ongoing additional research studies ogy research program concerned with include clinical characteristics of is diseases of the optic nerve. The overall chemic optic neuropathy in young pa- goals of the program are the develop- tients; improved differentiation of arte ment of new techniques for imaging ritic from nonarteritic anterior ischemic the optic nerve and its blood supply; optic neuropathy; identification of is an improved understanding and classi- chemic aspects of other rare optic fication of ischemic and inflammatory neuropathies, such as diabetic papil- optic nerve diseases; and the devel- lopathy, uremic optic neuropathy, and opment and evaluation of new thera- chemotherapy-induced optic neuropa- peutic modalities for these diseases. thy after bone marrow transplantation; and classification of unusual optic neu Dr. Arnold was a principal investigator ropathies, such as ethambutol-induced in the National Eye Institute-sponsored optic neuropathy and focal congenital clinical study of optic nerve sheath de- optic nerve hypoplasia. A study of dif- compression surgery for nonarteritic ferentiation of optic disc drusen from anterior ischemic optic neuropathy, papilledema has recently been com- and he was on the study’s Visual Field pleted. A major thesis entitled, The Data Analysis Committee. He is a pri- Spectrum of Optic Disc Ischemia, has mary advisor for an international multi- been submitted to the American Oph center study of risk factors for nonarte- thalmological Society. ritic anterior ischemic optic neuropathy.

34 Stein Eye Institute | Faculty Faculty

Gavin G. Bahadur, MD Public Service Health Sciences Assistant Clinical Professor of Ophthalmology Volunteer, Care Harbor Los Angeles

Informatics and Health Care Policy

Dr. Bahadur is a full-time ophthalmologist at the Stein Eye Center–Santa Monica, specializing in comprehensive ophthalmology, including cataract, pterygium, and glaucoma surgery. In addition to his clinical duties, Dr. Bahadur teaches medical students during their ophthalmology surgical subspecialties rotation. His research interests include medical informatics and health care policy.

Faculty | Stein Eye Institute 35 Faculty

Richard S. Baker, MD Public Service Associate Professor of Ophthalmology Trustee, California Medical Association Associate Director, Stein Eye Institute Center for Community Outreach and Policy, Chairman, Council for UCLA Center for Eye Epidemiology Scientific and Clinical Affairs, California Medical Association Executive Director, Center for Health Services Research Charles R. Drew University of Medicine and Science Secretary, Board of Trustees, Los Angeles County Chairman, Department of Ophthalmology Medical Association Charles R. Drew University of Medicine and Science Chairman, African American Physician Member of the Stein Eye Institute Advisory Committee, Los Angeles County Medical Association Vice Dean for Medical Education, Wayne State University School of Medicine Secretary, Board of Trustees, Latino Physicians of California Reviewer for multiple National Ophthalmic Epidemiology and Institutes of Health and Agency for Healthcare Research and Quality Health Services Research Special Emphasis Panels Reviewer for many scientific journals Dr. Baker’s primary areas of research interest are in the fields of ophthalmic epidemiology, health services research, and health information technol ogy, including telemedicine. Current projects in ophthalmic epidemiology include statistical analysis of national and statewide databases to produce definitive population-based estimates of the distribution and the determi- nants of major ophthalmic diseases and their treatments. As executive director of the Charles R. Drew Center for Health Services Re- search, Dr. Baker works closely with collaborators at the Stein Eye Insti tute and across UCLA on multiple projects related to improving access to care, optimizing the quality of care, and eliminating health disparities in diverse and underserved populations.

36 Stein Eye Institute | Faculty Faculty

John D. Bartlett, MD Public Service Ambulatory Practice Care Associate, Health Sciences Assistant Clinical Professor of Ophthalmology UCLA Health, Faculty Practice Group Member of the Stein Eye Institute Member, CareConnect Ambulatory Operations Advisory Group, UCLA Health Quality Officer, Stein Eye Institute Cataract and Refractive Surgery Interim Medical Director, University Ophthalmology Associates, Dr. Bartlett has an ongoing clinical in- Stein Eye Institute terest in cataract surgery, particularly refractive cataract surgery where the goal is to improve the focusing of the eyes and reduce dependence on glasses, while restoring vision potential. He is involved with teaching these surgical techniques to the Stein Eye residents, training the next generation of eye surgeons to deal with challenging cases.

Clinical Informatics As one of UCLA’s physician informaticists, Dr. Bartlett is involved in the ongoing implementation and optimi- zation of electronic health records (EHRs). UCLA physician informaticists engage in all aspects of understanding and promoting effective organization, analysis, management, and use of clinical information. Dr. Bartlett is interested in using EHRs to reach the “Triple Aim” of improved patient care and satisfaction, improved population health, and decreased cost of health care.

Faculty | Stein Eye Institute 37 Faculty

Suraj P. Bhat, PhD Public Service Professor of Ophthalmology Member, Joint Working Group INDO-US Collaboration in Member of the Molecular Biology Institute Vision Research Member of the Stein Eye Institute Assessor, National Health and Medical Research Council, Australia Editor, Molecular Vision Editorial Board Member, Molecular Biology of Vision Developmental Neuroscience Editorial Board Member, Dr. Bhat’s laboratory studies the regu- generated mouse models of this cata International Journal of Biochemistry lation of gene activity during differen- ract, thus enabling first-time investiga and Molecular Biology tiation and development of the verte- tion of this childhood pathology. Reviewer for many scientific journals brate eye. This involves isolation and characterization of genes and gene Studies on the function of the aB- products, identification of the regula- crystallin protein in the lens and the tory elements and factors, and eluci- RPE (in particular its relation to AMD) dation of their mechanisms employ- are focused on elucidating its “non- ing both in vivo and in vitro paradigms crystallin” function, which is relevant with manipulated gene sequences. both in the transparent and nontrans- parent physiology. These investiga- Two areas of research currently under tions have led Dr. Bhat’s laboratory investigation are focused on gaining to the discovery of the secretion of deeper insight into molecular mech- aB-crystallin from the RPE in lipo anisms that developmentally predis- protein vesicles known as exosomes, pose the eye to visual impairment and to initiate studies on elucidation of through ocular lens pathologies such intercellular communication (via exo- as cataracts, and through retinal dis- somes) in the RPE, in health, and eases including age-related macular in disease. degeneration (AMD). One area of attention is the study of the developmental and tissue-specific control of the aB-crystallin gene and its involvement in cataractogenesis. Another is the elucidation of the physiological function of the aB-crystallin protein in the ocular lens, in the neuro retina and retinal pigment epithelium (RPE), and in the brain. Technically this work involves gene manipulations and the study of their consequences on the phenotype, both in vitro (cultured cells) as well as in vivo (transgenic animals). Studies on the regulation of the expression of the small heat-shock protein gene, aB-crystallin, are focused on heat-shock transcription factor 4 (HSF4), which Dr. Bhat’s laboratory has reported to be the predominant heat-shock transcription factor of the developing lens, and its post-natal expression correlating with the most prevalent form of early childhood la mellar cataracts. Dr. Bhat’s group has

38 Stein Eye Institute | Faculty Faculty

Nicholas C. Brecha, PhD Public Service Distinguished Professor of Neurobiology, Ophthalmology, and Medicine Reviewer for many scientific journals Member of the Stein Eye Institute Member of the Brain Research Institute Member of CURE: Center for Digestive Diseases Member of the California NanoSystems Institute

Functional and Structural Organization of the Mammalian Retina

Dr. Brecha’s research focuses on the and global image processing, includ- elucidation of the structural and func- ing the formation of visual receptive tional organization of the outer and fields, blue-yellow color opponency, inner retina for understanding visual and ganglion cell gain. These inves- information processing by the retina. tigations are fundamental steps in Morphological studies are focused on establishing the retina’s functional or defining the different cell types and ganization and provide the basis for their microcircuitry in the outer and understanding the pathophysiology of inner retina. Neurochemical studies retinal dysfunction concomitant with have investigated the action of the retinal disease and injury. excitatory and inhibitory neurotransmitters and neuroactive peptides in these retinal microcircuits. Experimen- tal work has clarified the functional role of neuropeptides in the inner retina and supports the current hypothesis that certain dopamine and neuropeptides are modulators of retinal neurons and circuitry that influence light and dark adaptation; they also influence retinal circuitry that mediate pupillary reflexes and eye movements. Other experimental work has investigated the photoreceptor synaptic triad, a specialized synaptic complex that is the site of initial transfer of visual information from photoreceptors and is critically important for visual processing. Experimental studies are testing the idea that a gamma- Aminobutyric acid (GABA) mediated vesicular release underlies horizontal cell feedback and feed forward signaling, to cones and bipolar cells, respectively. The horizontal cell microcircuitry is critically important for both local

Faculty | Stein Eye Institute 39 Faculty

Joseph Caprioli, MD Public Service David May II Chair in Ophthalmology Chair, American Academy of Ophthalmology, Committee on Professor of Ophthalmology Practice Improvement Chief of the Glaucoma Division Clinical Volunteer, Venice Family Clinic Member of the Stein Eye Institute Editorial Board Member, American Journal of Ophthalmology, Investigative Ophthalmology and Visual Science, and Journal of Glaucoma Causes and New Treatments for Glaucoma Reviewer for many scientific journals

Dr. Caprioli’s long-term objective in Molecular Mechanisms of his clinical and basic research is to Retinal Ganglion Cell Damage identify those individuals at greatest and Neuroprotective Approaches risk for visual loss and to implement to Treatment new treatment strategies to prevent Basic science research under Dr. Cap- blindness. Currently, the only tool that rioli’s direction involves the mecha- physicians have to treat glaucoma nisms of glaucomatous optic nerve is reduction of intraocular pressure. damage. The stress protein response This treatment does not prevent visu- in a glaucoma model is being inten- al loss in a substantial proportion of sively studied. An important goal in patients whose damage progresses this research is to identify neuropro- quickly. The development of effective tective drugs that prevent the death neuroprotective avenues of treatment of retinal ganglion cells in mammali- will be a hallmark advance to elimi- an models of glaucoma, and to apply nate blindness from this disease. these findings to clinical trials of human glaucoma. Evaluation of Methods to Measure Rates of Glaucomatous Optic Nerve Damage Accurate assessment of optic nerve and nerve fiber layer is important to the early detection and timely treatment of glaucoma. Studies are under way to develop novel structural measures of the optic nerve and nerve fiber layer, which are sensitive and specific for early and progressive glaucomatous optic nerve damage. The goals of this work include identifying clinically implementable techniques to measure the rate of progressive damage. It is unlikely that a single structural or functional technique will be best throughout the course of the disease, and different methods will need to be applied at different stages to best measure disease progression.

40 Stein Eye Institute | Faculty Faculty

Richard Casey, MD Public Service Health Sciences Clinical Professor of Ophthalmology President, Los Angeles Ophthalmology Medical Group, Inc. Associate Member of the Stein Eye Institute

Cornea External Disease

Dr. Casey’s research is focused on un derstanding the causes of a variety of ocular surface and corneal disorders, with the intended goal to develop or improve treatments for patients with these disorders. He is currently col- laborating with both the Retina and Ophthalmic Pathology Divisions in separate clinical research projects. One study evaluates the ocular surface of patients undergoing corneal transplantation surgery to establish previously undescribed clinical-pathologic correlation with tear insufficiency and corneal epithelial abnormalities. A major outcome is to improve the success of corneal transplantation in high-risk patients with the comorbid conditions of tear insufficiency. He is also working with the Retina Division to determine which variables improve corneal transplant survival when corneal transplantation is combined with vitreoretinal surgery.

Public Health Services/ Health Access Dr. Casey has elected to dedicate a significant portion of his professional career to improving access to health care in specific underserved communities of Los Angeles. He has focused on assessing unmet needs in vision health to develop innovative strategies that address these deficits. He established the Los Angeles Ophthalmology Medical Group in 2001, which provides comprehensive eye care services in South Los Angeles.

Faculty | Stein Eye Institute 41 Faculty

Anne L. Coleman, MD, PhD Public Service The Fran and Ray Stark Foundation Chair in Ophthalmology Associate Editor, Editorial Board, American Journal of Ophthalmology Professor of Ophthalmology Mentor, Women’s Leadership, Professor of Epidemiology Association for Research in Vision and Ophthalmology Director of the Stein Eye Institute Centers for Community Outreach and Policy, Eye Epidemiology, and the UCLA Mobile Eye Clinic Council Chair, American Ophthalmological Society Vice Chairman of Academic Affairs, UCLA Department of Ophthalmology Member, Fight for Sight Member of the Stein Eye Institute Scientific Review Committee Member, Glaucoma Research Foundation Scientific Advisory Glaucoma, Cataract, and Committee Age-Related Macular Degeneration Member, Board of Trustees, Helen Keller International Dr. Coleman’s research is directed toward the diagnosis, treatment, and societal Board Member, International Council of impact of glaucoma, cataracts, and age-related macular degeneration, including Ophthalmology Foundation the study of lifestyle limitations imposed on patients with these kinds of eye Member, National Academy of diseases. Clinical projects include studies that analyze the prevention of visual Sciences, Engineering, and Medicine, impairment and blindness in school-age children, comparative effectiveness re- Committee on Human Rights search, and glaucomatous visual field and optic nerve progression. Member, NIH/CSR Neurological, Aging and Musculoskeletal Epidemiology (NAME) Study Section Review Group Member, National Glaucoma Research Review/Bright Focus Member, Research to Prevent Blindness Scientific Advisory Board Panel Director/Trustee, St. John of Jerusalem Eye Hospital Group US Hospitaller, The Most Venerable Order of the Hospital of St. John of Jerusalem

42 Stein Eye Institute | Faculty Faculty

Joseph L. Demer, MD, PhD Public Service Arthur L. Rosenbaum, MD, Chair in Pediatric Ophthalmology Editorial Board Member, Investigative Ophthalmology and Visual Science Professor of Ophthalmology Editorial Board Member, Journal of the Professor of Neurology American Association for Pediatric Ophthalmology and Strabismus Chief of the Pediatric Ophthalmology and Strabismus Division Associate Editor, Strabismus Member of the Stein Eye Institute Grant Reviewer, United States Public Health Service Scientific Advisory Committee Motility and Vision Member, Knights Templar Eye Foundation Dr. Demer studies the role of the brain and extraocular muscles in the control of Council Member, International eye movements and visual perception. He is directing a National Eye Institute re- Strabismological Association search project aimed at developing an understanding of the role of orbital connec- Reviewer for many medical and tive tissues and nerves in the development of binocular coordination disorders, scientific journals such as strabismus, and is developing new technologies for magnetic resonance imaging of extraocular muscles and nerves. This research has contributed to the knowledge of the functional anatomy of extraocular muscles and connective tissues, allowing development of new types of surgeries. An emerging research topic is the possible role of extraocular muscle forces in the development of optic neuropathies, such as glaucoma and anterior ischemic optic neuropathy. Dr. Demer’s research also employs novel micro- and nano-technological techniques to study the biomechanical properties of the extraocular muscles and associated tissues, as well as optical and x-ray imaging of the effects of physiological forces in the tissues.

Faculty | Stein Eye Institute 43 Faculty

Sophie X. Deng, MD, PhD Public Service Member, American Academy of Professor of Ophthalmology Ophthalmology Ophthalmic Technology Member of the UCLA Jonsson Comprehensive Cancer Center Assessment Committee, Cornea and Anterior Segment Disorders Panel Member of the UCLA Broad Stem Cell Research Center Member, Annual Meeting Program Member of the Stein Eye Institute Committee (Cornea Section), Association for Research in Vision and Ophthalmology Representative, Cornea Society, Limbal Stem Cell Deficiency Association of University Professors of Ophthalmology Fellowship Compliance Committee Dr. Deng’s research is focused on developed xenobiotic-free and feed er- improving the current diagnosis and free culture methods to expand autol Reviewer for many scientific journals treatments for patients with limbal ogous limbal stem cells in culture. Pre- stem cell deficiency. One of her on- clinical studies are ongoing to bring going clinical studies using laser scan- this stem cell therapy to restore vi- ning in vivo confocal microscopy in pa- sion in patients who suffer from lim- tients with limbal stem cell deficiency bal stem cell deficiency. shows correlated cellular changes in the cornea and limbus. Damages to Cornea Endothelial Dysfunction the limbal stem cells could be detect- Another area of Dr. Deng’s research ed and correlated with clinical presen- is the development of cell therapy tation. This new technique could al- to treat endothelial dysfunction by low for a better understanding of the regeneration of human corneal endo pathophysiology of limbal stem cell thelial cells. Currently, her laboratory deficiency. Another study focuses on focuses on investigating the signa- finding a better diagnostic marker for ture genes of cornea endothelial cells limbal stem cell deficiency. By using and the regulation of these quiescent the new diagnostic marker and in vivo cells. Another project aims to increase confocal imaging, a timely diagnosis the efficiency of expansion of corneal and staging of disease progression endothelial cells in culture and deri- could be achieved. vation of these cells from pluripotent stem cells. Dr. Deng’s laboratory studies the microenvironment/niche of the limbal stem cells to elucidate those factors that govern the fate of limbal stem cells. The role of the Wnt signal transduction pathway in human limbal stem/ progenitor cells is under investigation. Recent study in her laboratory reveals that activation of the Wnt/ß-catenin promotes self-renewal of limbal stem cells and that Frizzled 7 might be the receptor that mediates the Wnt activation. Use of small molecules to modulate Wnt signaling is being investigated to increase the efficiency of ex vivo expansion of limbal stem cells for transplantation. Dr. Deng’s laboratory is also trying to achieve patient-specific therapy by regenerating autologous limbal stem cells in a xenobiotic-free culturing system for transplantation. They have

44 Stein Eye Institute | Faculty Faculty

Debora B. Farber, PhD, DPhhc Public Service Scientific Advisory Board Member, Karl Kirchgessner Foundation Chair in Vision Science The Foundation Fighting Blindness; Distinguished Professor of Ophthalmology Visionary Scientists Board Member, Hope for Vision. Scientific Advisor Member of the Brain Research Institute and Board Member, The Vision of Children Foundation Member of the Molecular Biology Institute Editorial Board Member: Molecular Member of the Stein Eye Institute Vision; The Open Ophthalmology Journal; Journal of Ocular Biology, Diseases, and Informatics; and Stem Cells and Cloning Advances Retinal Biochemistry, Molecular Biology, and Applications Grant Reviewer: National Eye Institute; Genetics of Retinal Degenerations, and Studies on The Foundation Fighting Blindness; Embryonic Stem Cell-Derived Extracellular Vesicles The Vision of Children Reviewer for many scientific journals Dr. Farber’s research focuses on the Other projects center on the study study of genes involved in inherited of animal models of ocular albinism, retinal diseases, and on the charac- which lack the OA1 gene and are terization and use of human extracel- affected with permanent visual im- lular vesicles released by embryonic pairment. An important discovery of stem cells (ESEVs) for retinal thera- Dr. Farber’s team related to this work py. Her team has worked on several is that mutations in another gene, genes encoding proteins that play a Gai3, also cause ocular albinism. key role in vision and that when mutated cause blinding diseases. These Currently, the main focus of Dr. Far- ber’s group is the study of human include the b-PDE gene (mutated in rd mice, Irish setter dogs, and in ESEVs, nanoparticles that may have humans with autosomal recessive a pro-regenerative potential: by trig- retinitis pigmentosa (arRP); the RP1 gering molecular changes in Müller gene (responsible for a type of auto- glia they may favor regeneration of somal dominant RP); the gene caus- damaged retinas. ing disease in the rd7 mouse, a model for Enhanced S-Cone Syndrome; the a-transducin gene, disrupted in the Rd4 mouse, another model of retinal disease; the mouse homologue of the gene causing X-linked juvenile ret- inochisis (Xlrs1); and the cone genes ZBED4 and RHBDD2, that when mutated cause arCRD and arRP, respectively. Utilizing gene therapy methods, Dr. Farber and collaborators delivered the normal b-PDE gene to rd mouse retinas and rescued their photoreceptors. Dr. Farber’s group also worked on the mechanisms that regulate transcription and expression of retinal genes. They found that the transcription factor SP4 controls the activity of the b-PDE promoter and mutations in both SP4 and a-transducin cause digenic arRP and cone-rod dystrophy (arCRD).

Faculty | Stein Eye Institute 45 Faculty

Simon Fung, MD Public Service Committee member, Assistant Professor of Ophthalmology European Society of Ophthalmology Young Ophthalmologists Editor, European Society of Ophthalmology Pediatric Ophthalmology and Cornea Specialist Young Ophthalmologists newsletter

Dr. Fung’s clinical interests are childhood cornea and anterior segment diseases. His research focuses on evaluation of pediatric cornea conditions using novel imaging technologies. After finishing his residency in 2015, Dr Fung undertook a fellowship in adult cornea and external disease at Moorfields Eye Hospital in London, England, followed by a second fellowship in pediatric cornea and anterior segment at The Hospital for Sick Children in Toronto, Canada. Dr. Fung became a UCLA Department of Ophthalmology faculty member in 2018. Dr. Fung provides clinical care at the UCLA Stein Eye Institute in Westwood.

46 Stein Eye Institute | Faculty Faculty

JoAnn A. Giaconi, MD Public Service Faculty, Glaucoma section of American Health Sciences Associate Clinical Professor of Ophthalmology Academy of Ophthalmology’s Chief of the Ophthalmology Section at the Greater Los Angeles Basic and Clinical Science Course VA Healthcare System Program Committee, American Co-Director of Medical Student Education at the Glaucoma Society annual meeting David Geffen School of Medicine, UCLA President-Elect, Medical Student Member of the Stein Eye Institute Educators Council of the Association of University Professors of Ophthalmology Nominating Committee, Glaucoma American Academy of Ophthalmology Committee, American Glaucoma Society Strategic Plan Working Group Dr. Giaconi’s research focuses on the treatment of glaucoma. She is interested on Member Education in glaucoma surgery outcomes and side effects. She is currently working on various projects in the Veteran population, including examination of the over- Councilor and President-Elect, California Academy of treatment or undertreatment of glaucoma. She is enrolling patients in two clinical Eye Physicians and Surgeons studies at the Stein Eye Institute. One study is examining the effect of various glaucoma surgeries on the corneal endothelium, which is the layer of cells that Past President, Los Angeles Society of Ophthalmology keeps the cornea clear, and the other study is investigating a new surgical device. Volunteer, Eye Care America Reviewer for many scientific journals

Faculty | Stein Eye Institute 47 Faculty

Ben J. Glasgow, MD

The Wasserman Professor of Ophthalmology Professor of Pathology and Laboratory Medicine Chief of the Ophthalmic Pathology Division Member of the Stein Eye Institute

Ophthalmic Pathology

Dr. Glasgow’s research interests are primarily in the field of ophthalmic pathology. His major focus is the role of human lacrimal gland proteins in the protection and maintenance of the eye. His laboratory is investigating the structure-function relationship of tear lipocalin, the principal lipid carrier protein of tears. Currently, the labora tory has developed a technique called site-directed tryptophan fluorescence to probe and report information re garding molecular motion and solution structure. By studying the mo lecular mechanisms of tear proteins, Dr. Glasgow is seeking to learn the normal functions of tear lipocalin and its role in maintaining the health of the ocular surface and in the prevention of dry eye diseases. It is hoped that this research will lead to new treatments for dry eye and have broad application to numerous other members of this protein family that transport small, in- soluble molecules through the body.

48 Stein Eye Institute | Faculty Faculty

Robert Alan Goldberg, MD Public Service Karen and Frank Dabby Endowed Chair in Ophthalmology President, American Society of Ophthalmic Plastic and Professor of Ophthalmology Reconstructive Surgery Chief of the Orbital and Ophthalmic Plastic Surgery Division Fellowship Program Director, American Academy of Cosmetic Surgery and Director of the UCLA Orbital Disease Center American Society of Ophthalmic Plastic and Reconstructive Surgery Co-Director of the UCLA Aesthetic Center Member of the Stein Eye Institute Editorial Board Member, Archives of Ophthalmology, Ophthalmic Plastic and Reconstructive Surgery, Aesthetic Surgery Journal, and Archives of Facial Plastic Surgery Diseases and Therapy of the Eyelid and Orbit Section Editor, American Academy of Ophthalmology, ONE Network Research into the various surgical ap Outcomes of medical and surgical proaches to Graves orbitopathy (thy treatment of orbital and eyelid dis roid eye disease) has resulted in new orders are being studied in an orga- techniques that include less invasive nized, prospective fashion in order to small incision surgical approaches. In better understand which treatments addition, detailed clinical information are most effective. gathered from patients with Graves orbitopathy is being recorded in a shared database as a way to under stand the natural history and response to treatment of this multifaceted disease, which is a cause of significant visual loss and discomfort. Multicenter studies are underway. Dr. Goldberg is also investigating the underlying causes of thyroid-related orbitopathy. The goal of this research is to develop better tests to monitor disease activity, as well as new treatments to address the basic cause of the disease. Research into orbital and eyelid anato my, currently in progress, is resulting in improved techniques and approaches to deep orbital disease. Included is the use of high-resolution magnetic resonance imaging and high-resolution dy- namic ultrasonography to evaluate motility problems following trauma and orbital surgery, and three-dimensional analysis of orbital anatomy. Improved understanding of eyelid and orbital physiology and anatomy is the basis for developing improved surgical techniques. Instrumentation and devices that allow less invasive surgical approaches, such as hyaluronic acid gels, are being developed and studied. In collaboration with the Department of Engineering, custom materials for orbital reconstruction are investigated.

Faculty | Stein Eye Institute 49 Faculty

Lynn K. Gordon, MD, PhD Public Service Member, Board of Trustees, Vernon O. Underwood Family Chair in Ophthalmology American Academy of Ophthalmology Professor of Ophthalmology Past-Chair, Group on Women in Senior Associate Dean for Academic Diversity, Medicine and Science, American David Geffen School of Medicine at UCLA Association of Medical Colleges Chair of the College of Applied Anatomy, Member, Scientific Review Committee, David Geffen School of Medicine at UCLA Fight for Sight Committee Member of the Stein Eye Institute Member, Association for Research in Vision and Ophthalmology’s WEAVR Committee Co-Chair, Leadership Development Retinal Cell Biology and Inflammatory Disease Program for Women in ARVO Editorial Board Member, Ophthalmology, Investigative Dr. Gordon’s laboratory is involved in The second area of interest of Dr. Ophthalmology and Visual Science, two primary areas of research. One Gordon’s group is the role of pro- Journal of Neuro-Ophthalmology, and project investigates the role for epi- grammed death 1 (PD-1), a molecule Ocular Immunology and Inflammation thelial membrane protein 2 (EMP2) in that is known to play an important controlling ocular pathologic respons- role in immune regulation in the eye. es. Dr. Gordon and her colleagues PD-1 has a major function as a nega- identified that EMP2 plays an impor tive regulator in the immune system. tant role in an in-vitro model of pro- Although previous studies identified liferative vitreoretinopathy (PVR) and PD-1 expression in the lymphoid sys- have evidence that EMP2 is highly ex- tem, Dr. Gordon and her colleagues pressed in human retinal diseases. In identified its expression in neuronal addition, they recently identified that cells of the retina. Additionally her lab EMP2 controls VEGF production in oratory has identified that blockade of epithelial cells and in specific tumors. the PD-1 pathway may be protective The laboratory, in collaboration with in uveitis. Studies are ongoing to iden- others at UCLA, has recently devel- tify the mechanisms of that protection. oped a designer antibody fragment that has demonstrated efficacy in in- vitro studies in the PVR model and in other animal models in vivo. This antibody has now been successfully used to control pathologic neovascularization in a corneal burn model, achieving proof of principle for using this antibody to control disease.

50 Stein Eye Institute | Faculty Faculty

Michael B. Gorin, MD, PhD Public Service Member, Medical Education Harold and Pauline Price Chair in Ophthalmology Committee, David Geffen School of Professor of Ophthalmology Medicine at UCLA Professor of Human Genetics Editorial Board Member, Current Eye Research and Chief of the Division of Retinal Disorders and Ophthalmic Genetics Experimental Eye Research Member of the Stein Eye Institute Advisory Board Member, American Health Assistance Foundation Member, Ad Hoc Committee for Faculty Advancement and Promotions Hereditable Eye Disorders and Molecular Genetics for the Department of Human Genetics, UCLA of Age-Related Maculopathy Member, Special National Institutes of Health Study Sections for the National Dr. Gorin’s primary research focus work, opportunities have emerged to Eye Institute, National Institute on is molecular genetics of hereditable investigate the pathogenesis of light Aging (Claude Pepper Grants), National Human Genome Research, Center for eye disorders, specifically age-related sensitivity for individuals who suffer Inherited Disease Research macular degeneration (AMD). His re- from migraines and/or mild traumatic search group was the first to identify brain injury. Scientific Advisory Committee Member, BrightFocus Foundation specific regions of the genome that Clinical research efforts are directed and the Knights Templar Eye contributed to ARM development in Research Foundation families, leading to discovery of gene towards developing methods to monitor and quantify retinal function in pro- Member, Research Committee for the variations that contribute to the risk Blind Children’s Center, Los Angeles of developing ARM. He continues to gressive retinal disorders (such as dia work on studies of the genetics of betic retinopathy, Stargardt disease, Founding Member, and retinitis pigmentosa) and in pa- von Hippel-Lindau Center of Excellence AMD, in particular the use of genetic at UCLA Medical Center risk profiles to test for clinical mark- tients with potential ocular toxicities ers, including sensitive methods for from systemic medications. Applied Member, Clinical Research Governance Committee for UCLA detecting changes in retinal structure research interests include bioinformat and function that precede the onset ics in clinical ophthalmic practice and Member, Data Safety Monitoring of clinical disease. public health issues pertaining to oc- Board for jCyte RP Trial JC-01 ular disease. Reviewer for many scientific journals Dr. Gorin investigates the molecular genetics of complex disorders such as cystoid macular edema, age-related cataracts, and glaucoma, as well as monogenic disorders such as hereditary retinal degenerations, glaucoma, cataracts, and ocular syndromes. He is pursuing studies to identify genetic variations that contribute to the severity, complications, and therapeutic responses of these conditions. Dr. Gorin and his clinical team work with the clinical and research human genetics group at UCLA to explore use of new technologies, including next-generation sequencing for clinical utility in ophthalmic genetics. Research also focuses on the neurobiology of ocular pain and photophobia (sensitivity to light) to understand the basic biology and neural pathways that contribute to photophobia so that new therapeutic strategies can be developed. Based upon preliminary

Faculty | Stein Eye Institute 51 Faculty

David Rex Hamilton, MD, FACS Public Service Editorial Board Member, Health Sciences Clinical Professor of Ophthalmology Ophthalmology, Journal of Refractive Director of the UCLA Laser Refractive Center Surgery, and Journal of Cataract and Refractive Surgery Member of the Stein Eye Institute Member, Refractive Leadership Council, Alcon Laboratories Member, ASCRS Refractive Surgery Advanced Intraocular Lenses Clinical Committee Member, ASCRS Refractive Surgery/ Cataract Clinical Subcommittee Dr. Hamilton’s research interests are in the areas of corneal biomechanics Member, American Academy and tomography (3D imaging of the of Ophthalmology, Preferred Practice Pattern Committee for cornea), screening for corneal ectat- Refractive Surgery ic disorders, and the clinical study of intraocular lenses (IOLs) for the treat- Member, American Academy of Ophthalmology, ONE Network, ment of high myopia (phakic IOLs), Refractive Surgery astigmatism (toric IOLs), and presby opia (multifocal and accommodating IOLs). Dr. Hamilton is actively involved in training residents and fellows in the surgical treatment of refractive errors and cataracts.

52 Stein Eye Institute | Faculty Faculty

Gary N. Holland, MD Public Service Associate Editor, American Journal Jack H. Skirball Chair in Ocular Inflammatory Diseases of Ophthalmology Professor of Ophthalmology Editorial Board, EyeNet Magazine Director of the Ocular Inflammatory Disease Center (American Academy of Ophthalmology), Section Editor, Uveitis Director of the UCLA Department of Ophthalmology Clinical Research Center Executive Committee Member, Co-Director of Medical Student Education American Uveitis Society Member of the Stein Eye Institute

Uveitis and Cornea-External Ocular Diseases

Dr. Holland’s research deals with in- Chronic anterior uveitis is a common fectious and inflammatory diseases complication of juvenile idiopathic of the eye, including ocular toxo- arthritis (JIA). Dr. Holland is study- plasmosis; HIV-related eye disease; ing risk factors for, and treatment of, chronic anterior uveitis in children; vision-threatening complications of and birdshot chorioretinopathy. Clin- JIA-associated uveitis, including glau- ical studies are being performed to coma, and he is interested in the psy identify populations at greatest risk chosocial impact of uveitis on children for these ocular diseases and factors and their families. that influence disease severity. Stud- ies also investigate the course of Birdshot chorioretinopathy is a chron- these diseases and response to new ic autoimmune disease of the eye. treatments. Better understanding of Dr. Holland is participating in several these conditions may lead to im- multicenter studies involving retinal proved disease management. imaging and electrophysiologic techniques to understand the basis for vi- Ocular toxoplasmosis, caused by a sion loss among people with the dis- parasite, is the most common retinal ease. He also helped to organize and infection in the general population. is analyzing data from a 10-year lon- With investigators in North America, gitudinal clinical study of the disease Brazil, and Europe, Dr. Holland is in Paris, France, that involves a large studying human and parasitic genetic cohort of patients. factors that influence risk for ocular involvement among people infected with the parasite. Dr. Holland continues to study cytomegalovirus (CMV) retinitis, the most serious eye problem among HIV- infected individuals, and still a major public-health problem in many areas of the world because of the AIDS pan- demic. He is also investigating HIV- related “neuroretinal disorder” (NRD), a degenerative condition that causes deterioration of vision and reduced quality of life, even among individuals whose immune function has improved because of antiretroviral drugs. NRD is also a marker of non-ocular, life-threatening diseases among HIV- infected people.

Faculty | Stein Eye Institute 53 Faculty

Hamid Hosseini, MD

Assistant Professor of Ophthalmology

Retinal and Macular Conditions

Dr. Hosseini specializes in retinal and macular conditions, such as macular degeneration, diabetic retinopathy, and retinal detachment. Dr. Hosseini completed two fellowships at the UCLA Stein Eye Institute, the first in glaucoma and the second in retina. He participates in all activities of the Retina Division, including research, education, and clinical care. He sees patients at the Stein Eye Institute in Westwood and Harbor-UCLA Medical Center.

54 Stein Eye Institute | Faculty Faculty

Wayne L. Hubbell, PhD Public Service Member, National Academy Jules Stein Chair in Ophthalmology of Sciences Distinguished Professor of Ophthalmology Member, American Academy Distinguished Professor of Chemistry and Biochemistry of Arts and Sciences

Molecular Basis of Phototransduction in the Vertebrate Retina

Dr. Hubbell’s research is focused is obtained and changes in the struc- on understanding the complex rela- ture during function can be followed tionship between molecular struc- in real time. While determination of ture, plasticity, and conformational static protein structure is important changes that control protein function to understanding function, current re- in the visual system. Of particular search has highlighted a crucial role for interest are proteins that behave as protein flexibility (dynamics), which has “molecular switches,” that is proteins not been previously appreciated. To ex- whose structures are switched to an plore molecular flexibility in proteins of active state by a physical or chemical the visual system, Dr. Hubbell’s group signal. Examples include rhodopsin, is developing novel methods using the membrane-bound photoreceptor time-domain and high-pressure EPR. protein of the retina, and transducin and arrestin, proteins that associate with rhodopsin during function. The overall goal is to determine the structure of these proteins in their native environment, monitor the changes in structure that accompany the tran sition to an active state, and to understand the role of protein flexibility in function. To investigate these and other proteins, Dr. Hubbell’s laboratory has developed the technique of site-directed spin labeling, a novel and powerful approach to the exploration of protein structure and dynamics. By changing the genetic code, a specific attach- ment point in the protein is created for a nitroxide spin label probe. Anal- ysis of the electron paramagnetic resonance (EPR) spectrum of the spin label provides information about the local environment in the protein. With a sufficiently large set of labeled proteins, global information on structure

Faculty | Stein Eye Institute 55 Faculty

Jean-Pierre Hubschman, MD Public Service Associate Professor of Ophthalmology Reviewer for many scientific journals Member of the Stein Eye Institute

Advanced Vitreoretinal Surgical Interventions and Robotics

Dr. Hubschman’s clinical research focuses on the development and evaluation of new vitreoretinal surgical techniques and robotics for ophthalmic surgery. Automated surgery utilizing robotics promises to increase surgical precision and accuracy, as well as improve access to medical care. Dr. Hubschman’s publications include research papers on the development of a new retinal patch for the treatment of retinal detachment, on the feasibility of robotic surgery in ophthalmology, and results of various clinical trials. Currently, he is also investigating the use of the terahertz laser for the evaluation of ocular tissue hydration.

56 Stein Eye Institute | Faculty Faculty

Sherwin J. Isenberg, MD Public Service Past-President, American Association Laraine and David Gerber Chair in Ophthalmology for Pediatric Ophthalmology Distinguished Professor of Ophthalmology and Strabismus Professor of Pediatrics Member, Medical Advisory Board and Board of Directors; and Member of the Stein Eye Institute Research Committee Chair, Blind Children’s Center Past President, Costenbader Pediatric Ophthalmology Society Pediatric Ophthalmology, Amblyopia, and Co-Founder and Delegate, Ophthalmic Pharmacology International Pediatric Ophthalmology and Strabismus Council Dr. Isenberg’s research activities have Lastly, a new device that reports blood concentrated on various aspects of gases from the conjunctiva, such as surgical and medical diseases of chil- oxygen and carbon dioxide, is being dren’s eyes. The goal is to decrease developed. Preliminary trials have been the frequency of blindness in children completed in animals and in adults un- worldwide. In a series of studies of dergoing cardiac bypass surgery. The newborns, Dr. Isenberg has charac- hope is to apply the device to the eyes terized a number of elements, includ- of premature newborns. The continu ing: the type and source of bacteria ous readout of tissue blood gas le vels of the external eye at birth; the evo- should enable the pediatrician to pre- lution of iris structural changes; the vent damage to the baby’s brain and development of the macula, which keep the oxygen at an appropriate lev- is the source of central vision; and el, minimizing the possibility of blind- pupillary responses after birth. Re- ness from retinopathy of prematurity. cent publications have characterized the production and nature of tears of infants and the development of the cornea in the first year of life. He has also reported the ocular signs in newborns whose mothers abuse cocaine, facilitating the diagnosis of newborn cocaine intoxication. In another avenue of research, povidone-iodine eyedrops have been found to treat bacterial conjunctivitis successfully in a three-year, international study with the University of the Philippines. The eyedrops were also found to be safer and more effective in preventing eye infections than the currently used agents. Dr. Isenberg and other investigators have now proven that the povidone-iodine eyedrops can treat the number one cause of preventable pediatric blindness in the world—corneal infections due to bacteria. These studies, conducted in children and adults in India and the Philippines, should reduce the number of 400,000 children now blind from corneal infections. A new study investigating fungal infections of the eye, which blind approximately 10,000 children annually, has been completed at three sites in India.

Faculty | Stein Eye Institute 57 Faculty

Simon K. Law, MD, PharmD Public Service Expert Reviewer, Medical Board Health Sciences Clinical Professor of Ophthalmology of California Member of the Stein Eye Institute Pharmacy Editor, eMedicine Member of the Committee on Aging, American Academy of Ophthalmology Optic Disc Evaluation Subcommittee Member, American Academy of Ophthalmology Basic and Clinical Science Course Dr. Law’s principal research interest LASIK and Glaucoma Reviewer for many scientific journals focuses on the structural appearance LASIK refractive procedure has been of the optic disc in different ocular popular for many years for patients diseases, including patients with high with high myopia. As high myopia myopia. Assessment of optic disc size is a risk factor for glaucoma, some is an important component of the di middle-aged patients with prior LASIK agnostic evaluation for glaucoma. Pa- have developed the disease. Because tients with high myopia are at greater of LASIK’s effect on the cornea, eye risk of developing glaucoma, and they pressure estimation has been inac- also have an atypical optic disc that curate after LASIK, and monitoring makes diagnosis difficult. The purpose of glaucoma is difficult in these eyes. of Dr. Law’s research is to character- Dr. Law is currently studying the out- ize the appearance of the optic disc in comes of glaucoma management in eyes with high myopia and to identify glaucoma patients who have had a the related risk factors for develop- prior LASIK refractive procedure. ment of glaucoma.

Glaucoma Filtering Procedure Trabeculectomy is the traditional time- honored procedure for glaucoma, and it is considered the gold standard by which newer procedures are compared. The success rate of trabeculectomy, however, is lower in eyes that have undergone prior intraocular surgery. Dr. Law is interested in perfect- ing the procedure in these cases and in developing a surgical technique to improve the pressure reduction function in current trabeculectomy.

58 Stein Eye Institute | Faculty Faculty

Ralph D. Levinson, MD Public Service ONE Committee, American Academy Health Sciences Clinical Professor of Ophthalmology of Ophthalmology Member of the Stein Eye Institute Reviewing Editor, Ocular Immunology and Inflammation Institutional Review Board Member, UCLA Ocular Inflammatory Diseases Reviewer for many scientific journals Dr. Levinson’s research interest is in both the clinical aspects of uveitis and the basic mechanisms and immunogenetics of ocular inflammation. Current projects include a collaborative longitudinal study of a chronic inflammatory disease, birdshot chorioretinopathy, with investigators in France. The study focuses on the in- terrelationship of disease factors, as well as the course of disease and response to treatment. Dr. Levinson is also conducting laboratory research on cell-based therapies for uveitis and is a co-investigator for National Eye Institute-funded laboratory research on the effects of cancer immunother- apy on uveitis.

Faculty | Stein Eye Institute 59 Faculty

Colin A. McCannel, MD Public Service Professor of Clinical Ophthalmology Moderator, “Retina Talk” online discussion forum, American Member of the Stein Eye Institute Association of Retina Specialists Chair, Editorial Committee, Retina and Vitreous Basic and Clinical Science Course, Section 12, American Vitreoretinal Surgery Academy of Ophthalmology Medical Information Technology Committee Member, American Dr. McCannel has a longstanding interest in the management of vitreoretinal Academy of Ophthalmology conditions, particularly complex retinal detachments, complications of diabetic retinopathy, macular holes and epimacular membranes, and age-related macu- Reviewer for many scientific journals lar degeneration. His clinical research efforts are directed at the improvement of vitreoretinal surgical techniques and outcomes, including the prevention of endophthalmitis following intravitreal injections. Dr. McCannel devotes time to educational research as well. Currently, he is investigating the utility of virtual reality surgery simulation in teaching ophthalmic surgery. He has several ongoing protocols that assess ophthalmic surgical simu lation in surgical teaching.

60 Stein Eye Institute | Faculty Faculty

Tara A. McCannel, MD, PhD Public Service Reviewer for many scientific journals Health Sciences Associate Clinical Professor of Ophthalmology Director of the Ophthalmic Oncology Center Member of the Stein Eye Institute

Metastatic Ocular Melanoma

Dr. McCannel’s primary research interest is metastatic ocular melanoma. Under her direction, the Ophthalmic Oncology Laboratory is studying molecular markers in ocular melanoma to provide prognostic information to pa tients and advance understanding of metastatic disease. Discovery of can- didate genes from tissue of patients undergoing surgical treatment for ocular melanoma is being explored. This information will be important to estab lish a better understanding of the bi ology of metastatic ocular melanoma and help develop better treatments for this cancer. New modalities are being investigated to predict, detect, and ultimately treat choroidal mela noma metastasis.

Surgical Approaches to Vitreoretinal Disease and Cancer Dr. McCannel is both a vitreoretinal Health Psychology and surgeon and an ophthalmic oncologist. Ocular Melanoma She manages the spectrum of vitreo Central to incorporating an integra- retinal disease in addition to the surgi- tive approach to health care, the con- cal management of ocular melanoma, cerns and wishes of the patient as allowing patients to benefit maximally a whole are important aspects of from her wide range of surgical prog- cancer management. In collaboration nostic and therapeutic expertise. with the UCLA Department of Health Vitrectomy with silicone oil placement Psychology and the Jonsson Compre- is a novel therapeutic strategy, which hensive Cancer Center, Dr. McCannel was discovered at UCLA to reduce ra- works closely with health psycholo- diation exposure to the healthy struc- gists who are interested in providing tures of the eye during plaque surgery clinical care while researching factors, for melanoma treatment. Dr. McCan- which predict psychological adjust- nel offers this potentially sight-saving ment to cancer. technique to patients who need radiation treatment.

Faculty | Stein Eye Institute 61 Faculty

Kevin M. Miller, MD Public Service Course Director, Southern California Kolokotrones Chair in Ophthalmology Basic and Advanced Cataract Surgery Professor of Clinical Ophthalmology Courses for Residents and Fellows Chief of the Cataract and Refractive Surgery Division Co-Organizer, Biannual Curso Universitario Internacional de Director of the Anterior Segment Diagnostic Laboratory Oftalmologia, Santiago, Chile Member of the Stein Eye Institute American Academy of Ophthalmology, Skills Transfer Course Advisory Committee American Academy of Ophthalmology, Cataract and Refractive Surgery Annual Meeting Program Committee, Cataract Subcommittee Dr. Miller’s research interests are in to refractive cataract surgery and ICL American Academy of Ophthalmology, Preferred Practice Patterns Committee, cataract and refractive surgery, intra- implantation, he also performs DSEK, Anterior Segment Panel ocular lenses, artificial iris implants, LASIK, PRK, and other cornea-based ophthalmic optics, surgical devices, laser refractive procedures. American Society of Cataract and Refractive Surgery, Cataract Clinical and surgical outcomes. Dr. Miller runs several clinical trials of Committee, Retina Clinical Committee, and Skills Transfer Subcommittee Dr. Miller’s clinical practice focuses artificial iris implants to treat congeni- primarily on refractive cataract sur- tal and acquired aniridia. He completed Executive Editor, gery and the surgical correction of the multicenter Ophtec 311 clinical trial. American Journal of Ophthalmology presbyopia and astigmatism with pre He has an individual device exemption Faculty of 1000, Post-Publication mium technology intraocular lenses. from the FDA to study Morcher arti- Peer Review, Lens Disorders Section He developed an astigmatism man- ficial iris implants. He is the only sur- International Editorial Board, agement service for treating corneal geon in the United States who is per- Oftalmologia Em Foco and astigmatism at the time of cataract mitted by the FDA to implant Morcher Revisita Brasileira de Oftalmologia surgery that optimizes postoperative devices at this time. He is also study- Editorial Board, Cataract Section, uncorrected visual acuity. He devel- ing a custom artificial iris implant from American Society of Cataract oped a nomogram for peripheral cor- Dr. Schmidt Intraocularlinsen, a sub- and Refractive Surgery, EyeWorld Magazine neal relaxing incisions and participated sidiary of HumanOptics. All of these in the clinical trial of the world’s most devices are showing promising results Editorial Board, Cataract and popular toric intraocular lens. He was in patients who suffer from congenital Refractive Surgery Today instrumental in bringing femtosecond and acquired iris defects. Editorial Board, American Academy of laser technology to UCLA for use in Ophthalmology, EyeNet Magazine Finally, he is an investigator in the cataract surgery. He described a non- Reviewer for many scientific journals parametric multivariate technique for RxSight light adjustable lens study comparing astigmatism outcomes be- and the Alcon Laboratories high-power tween treatment groups. In addition toric lens post-market approval study.

62 Stein Eye Institute | Faculty Faculty

Bartly J. Mondino, MD Public Service Medical Advisory Board Member, Bradley R. Straatsma, MD, Endowed Chair in Ophthalmology Braille Institute Distinguished Professor of Ophthalmology Editorial Board Member, Ophthalmic Chairman, UCLA Department of Ophthalmology Surgery, Lasers and Imaging Director, Stein Eye Institute Vice President and Board of Directors Member, National Alliance for Member, UCLA Brain Research Institute Eye and Vision Research Board of Directors (Observer), Doheny Eye Institute Affiliation Chairman, Doheny Eye Institute

Cornea and External Ocular Diseases and Immunological Disorders

Dr. Mondino’s research activity is focused on cornea-external ocular diseases, with particular emphasis on immunological disorders. He has studied the role of lymphocytes and the complement system in the immunopathogenesis of anterior segment diseases. In addition, a model of staphylococcal hypersensi tivity lesions of the cornea was explored as well as the immune response to staphylococcal endophthalmitis. Other research interests included corneal dystrophies, peripheral corneal ulcers, bullous diseases of the skin and mucous membranes, collagen shields, and contact lens-related corneal ulcers.

Faculty | Stein Eye Institute 63 Faculty

Kouros Nouri-Mahdavi, MD, MSc Public Service Member, American Academy of Associate Professor of Ophthalmology Ophthalmology Glaucoma Registry Director of the Glaucoma Advanced Imaging Laboratory Measures Working Group Member of the Stein Eye Institute Member, American Glaucoma Society Patient Care Committee, Document Subcommittee Member, Residency Program Role of Structural and Functional Measurements for Evaluation Committee Member, Stein Eye Institute Detection of Glaucoma and Its Progression Electronic Medical Record Implementation Committee Dr. Nouri-Mahdavi’s research is fo- Glaucoma Treatment Outcomes Member, Glaucoma Progression cused on improving methods to de- and Role of Ethnicity Scholars tect early glaucoma and glaucoma de- Dr. Nouri-Mahdavi is also interested terioration with spectral-domain optical Member, International Education in studying glaucoma treatment out- Subcommittee, Education and coherence tomography (SD-OCT) and comes and their variations as a func- Communication Committee, various perimetry techniques. More tion of ethnicity. An ongoing study is American Glaucoma Society specifically, he is interested in de comparing the long-term outcomes Advisory Board Member, tection of glaucoma progression in of trabeculectomy with adjunctive mi- Journal of Current Ophthalmology patients with advanced disease. Dr. tomycin C in patients of African de- Editorial Board Member, Journal of Nouri-Mahdavi is currently exploring scent to those of European descent. Ophthalmic and Vision Research the role of macular imaging for detection of glaucoma progression in a co- Glaucoma Section Editor, Journal of Vision and Eye Research hort of advanced glaucoma patients. Methodologist, American Academy of Ophthalmology Ophthalmic Technology Assessment Committee Volunteer, EyeCare America, provide ophthalmic patient screening at annual Los Angeles charity clinic events Reviewer for many scientific journals

64 Stein Eye Institute | Faculty Faculty

Steven Nusinowitz, PhD Public Service Editorial Board Service, Professor of Ophthalmology Current Eye Research Co-Director of the Visual Physiology Laboratory Grant Reviewer: National Eye Institute Director of the Live Imaging and Functional Evaluation (LIFE) Core (ad hoc) Member of the Stein Eye Institute Intramural Program Review Committee: National Eye Institute Scientific Advisor: The Mouse Mutant Resource, The Jackson Laboratory; and Ionis (formerly ISIS) Mechanisms of Retinal Degeneration Pharmaceuticals, Inc.

Dr. Nusinowitz’s primary research in- Data Safety Monitoring (Clinical Trials): New Drug Investigations, Ionis terest is focused on understanding (formerly ISIS) Pharmaceuticals, Inc. the cellular contributions to noninva- Allergan Pharmaceuticals sive measures of visual function and Reviewer for Current Eye Research, defining the sites and mechanisms Experimental Eye Research, of disease action in inherited retinal Investigative Ophthalmology and and visual pathway disorders. In his Vision Science, Visual Neurosciences research laboratory, Dr. Nusinowitz’s main approach to gaining an understanding of the site and mechanism of vision loss in humans is to study the patterns of electrophysiological responses obtained from mice in which the disruption of different cells or pathways in the visual system are specifically targeted by genetic manipulation. By comparing the patterns of responses in human disease with the patterns of responses from ro- dents with targeted cellular disruption, Dr. Nusinowitz is able to test hypothe- ses about the underlying pathophysiology in human disease and to provide a mechanism for the development of specific diagnostic tools that are sufficiently sensitive for early detection and better diagnosis of clinical disease. In addition, on a more applied level, Dr. Nusinowitz’s research studies in both humans and mice have involved investigations testing the efficacy of multiple therapeutic interventions for retinal disease, including pharmacological, viral, and stem cell therapies.

Faculty | Stein Eye Institute 65 Faculty

Stacy L. Pineles, MD Public Service Member, Department of Jerome and Joan Snyder Chair in Ophthalmology Ophthalmology Residency Training Associate Professor of Ophthalmology Committee and Department of Ophthalmology Residency Member of the Stein Eye Institute Selection Committee Associate Residency Director, Department of Ophthalmology Secretary/Treasurer, UCLA Stein Eye Pediatric Neuro-Ophthalmology, Amblyopia, and Institute Alumni Association, Neurologic Causes of Strabismus Department of Ophthalmology Member, Research Committee, Dr. Pineles’ research interests include American Academy of Pediatric evaluating the surgical outcomes of Ophthalmology and Strabismus strabismus surgery and studying pe- Member, Professional Education diatric optic nerve diseases. With her Committee, American Academy dual training in pediatric ophthalmol- of Pediatric Ophthalmology and Strabismus ogy and neuro-ophthalmology, she has a special interest in pediatric Member, Adult Strabismus Task Force, American Academy of Pediatric neuro-ophthalmic diseases, as well Ophthalmology and Strabismus as adult patients with amblyopia and neurologic causes of strabismus. Member, Young Neuro- Ophthalmologists Committee, North American Neuro-Ophthalmology Society Member, Walsh Committee, North American Neuro-Ophthalmology Society Member, Ophthalmic Technology Assessment Committee Pediatric Ophthalmology and Strabismus, American Academy of Ophthalmology Reviewer and editorial board member for many scientific journals

66 Stein Eye Institute | Faculty Faculty

Natik Piri, PhD Public Service Editorial Board Member, Journal of Professor of Ophthalmology Synthesis Theory and Applications, Member of the Stein Eye Institute Advances in Medicine: Ophthalmology, and the Journal of Neurophysiology and Neurological Disorders Reviewer for many scientific journals Retinal Ganglion Cell Biology, Glaucomatous Neurodegeneration, and Neuroprotection

The main directions in Dr. Piri’s re- Another area of investigation focuses search are defining the mechanisms on understanding the degeneration of leading to retinal ganglion cell (RGC) RGCs and their axons, which is a hall- degeneration in glaucomatous neurop mark of glaucoma. Dr. Piri’s laboratory athy; developing strategies for preserv is analyzing retinal gene expression ing RGCs against neurodegeneration; profiles from the glaucoma model and identifying and characterizing the with the aim of identifying factors in- genes critical for RGC function and involved in the initiation and execution tegrity. Different types of RGCs have of RGC apoptosis. Study results have been identified based on their mor- implicated several members of the phological and physiological character- crystallin superfamily in this process, istics, yet current knowledge of RGC including alpha crystallins. Dr. Piri is molecular biology is very limited. Char- also studying the involvement of oxi acterization of RGC-expressed genes dative stress and proteins of the thio is fundamental to a better understand redoxin system, particularly in RGC ing of normal RGC physiology and degeneration in the glaucoma model, pathophysiology. and the neuroprotective effects of these proteins against glaucomatous RGC death.

Faculty | Stein Eye Institute 67 Faculty

Pradeep S. Prasad, MD, MBA Public Service Ophthalmology Clerkship Director, Health Sciences Assistant Clinical Professor UCLA School of Medicine Chief, Division of Ophthalmology, Harbor-UCLA Medical Center Member of the Stein Eye Institute

Vitreoretinal Surgery and Disease Management

Dr. Prasad specializes in the medical and surgical management of diseases of the retina and vitreous. His research is focused on teleretinal screening for diabetic retinopathy, applications of wide-field fundus photog raphy for retinal vascular disease, and health care delivery for low-income populations. Dr. Prasad also serves as the chief of the Division of Ophthal- mology at Harbor-UCLA Medical Cen- ter where he provides clinical supervision and instruction to UCLA medical students as well as to Stein Eye residents and vitreoretinal fellows.

68 Stein Eye Institute | Faculty Faculty

Roxana A. Radu, MD Public Service Member, Association for Research in Assistant Professor of Ophthalmology Vision and Ophthalmology Reviewer for Fight for Sight grant applications in the United States and Retina Biochemistry and United Kingdom Clinical Disease Modeling Laboratory Board Member, JSEI Affiliates Reviewer for many scientific journals Dr. Radu is a basic science researcher at the Stein Eye Institute. She is a medical doctor who trained as a biochemist during her postdoctoral fellowship at the Institute. The focus of Dr. Radu’s laboratory research is studying the formation and pathogenic roles of bisretinoid-pigments (vitamin A condensation products) in the retinas of humans with macular degeneration, such as recessive Star- gardt disease (STGD1) and age-related macular degeneration (non-vascularized form). The main aim of this research is to develop and characterize disease models—cell-based and mouse lines—to advance understanding of the patho genesis of maculopathies and potentially lead to novel therapeutic approaches to treat these blinding diseases. Dr. Radu’s group investigates the mechanisms by which ABCA4 mutations result in the STGD1 phenotype, and they explore the bisretinoid-mediated complement dysregulation in the retinal pigment epi thelium cells as a key player in visual loss from early and late-onset macular degenerations. Other areas of study include the regulation of the visual cycle for chromophore regeneration by non-visual opsins.

Faculty | Stein Eye Institute 69 Faculty

Alapakkam P. Sampath, PhD Public Service Member, Association for Research Professor of Ophthalmology and Neurobiology in Vision and Ophthalmology Associate Director of the Stein Eye Institute Publications Committee Associate Director of the Vision Science Division Member, Neurotransmitters, Transporters, Receptors and Member of the Stein Eye Institute Calcium Study Section, NIH

Molecular Mechanisms Underlying Early Visual Processing

The Sampath laboratory is interested in understanding the molecular mechanisms underlying early visual processing. In particular, the focus of laboratory researchers has been on elucidating mechanisms that set the sensitivity of night vision. Night blindness, or nyctalopia, is a condition that results from abnormal signaling by the rod photoreceptors, or the retinal circuits that process rod-driven signals. Using physiological and genetic methods, the laboratory studies signal transmission in these retinal rod pathways to identify how these processes are optimized to allow our exquisite visual sensitivity.

70 Stein Eye Institute | Faculty Faculty

David Sarraf, MD Public Service Associate Editor, Retinal Cases and Health Sciences Clinical Professor of Ophthalmology Brief Reports Member of the Stein Eye Institute Editorial Board Member: Retina; Ophthalmic Surgery, Lasers and Imaging Retina (OSLI Retina); and Ophthalmology @ Point of Care Age-Related Macular Degeneration and Retinal Imaging Advisory Board Member: OCT Angiography, Diabetic Retinopathy Clinical Research Network; Dr. Sarraf is a member of the Retinal Dr. Sarraf has been awarded achieve- Optovue, Inc. Disorders and Ophthalmic Genetics ment and secretariat awards by the Division of the Stein Eye Institute. He American Academy of Ophthalmol- Member: American Society of Retinal Specialists, Retina Society, has published approximately 200 re- ogy, and he is a leader in advanced Macula Society, Gass Club, American search papers, case reports, reviews, retinal imaging. He has published ex- Ophthalmological Society and book chapters and is co-author of tensively in the area of spectral do- Program Committee Member, The Retinal Atlas, 2nd edition. main optical coherence tomography Macula Society (SD-OCT) analysis of AMD and other Co-Director, Pacific Retina Club Dr. Sarraf’s focus of research inter- novel and established macular disor- est includes the dry and wet forms and International Retinal Imaging ders. He was one of the first research- Symposium of age-related macular degeneration ers to describe ischemia of the deep (AMD) and specifically the evaluation Co-Founder, International Retinal retinal capillary plexus using advanced Imaging Society of pigment epithelial detachment SD-OCT imaging, and he is a world (PED) and retinal pigment epitheli- expert on the clinical application of Reviewer for many scientific journals al tears. He was nominated to the OCT angiography. American Ophthalmological Society because of his research work on the subjects of PED and AMD. Dr. Sarraf leads various national and international trials at UCLA for the diagnosis and treatment of AMD and diabetic retinopathy.

Faculty | Stein Eye Institute 71 Faculty

Steven D. Schwartz, MD Public Service Program Committee Member, The Ahmanson Chair in Ophthalmology Association for Research in Vision Professor of Ophthalmology and Ophthalmology Chief of the Retina Division Diabetic Eye Disease Screening, Venice Family Clinic Director of the UCLA Diabetic Eye Disease and Retinal Vascular Center Director of the Macula Center Member of the Stein Eye Institute

Stem Cell Research

Dr. Schwartz is leading two new clinical trials testing the use of stem cell-derived retinal pigment epithelial cells to address vision loss in people suffering from Stargardt macular dystrophy and dry age-related macular degeneration.

Retinal Diseases Dr. Schwartz’s primary areas of research include early diagnosis and treatment of diseases such as retinopathy of prematurity (ROP), diabetic eye disease, and macular degeneration. Additionally, his focus includes development and evaluation of novel medical device technologies, imaging technologies, surgical equipment (including surgical robots), and drug- delivery systems, with particular emphasis on diagnostic and treatment applications. Dr. Schwartz’s clinical research focuses on trials of novel pharmacotherapeutic agents to dis- cover treatments for both wet and dry age-related macular degeneration, ROP, and diabetic retinopathy. Through innovative teleophthalmolog- ical approaches to screen for eye diseases, such as diabetic retinopathy and ROP, Dr. Schwartz is dedicated to improving both the quality of and access to specialized ophthalmology care. Currently, a collaborative pr ogram with UCLA’s Gonda Diabetes Center and Venice Family Clinic is underway, in which screening for diabetic retinopathy is conducted with a nonmydriatic camera (a camera that does not require dilation of the eyes) as part of each patient’s regular diabetes treatment. Results are telecommunicated to specialists at the Stein Eye Institute for interpretation and further action.

72 Stein Eye Institute | Faculty Faculty

Hui Sun, PhD Public Service Ad hoc reviewer for NIH/NEI Professor of Physiology and Ophthalmology Special Emphasis Panels Member of the Stein Eye Institute Ad hoc reviewer for Natural Sciences and Engineering Research Council, Canada

Molecular Mechanism of Vitamin A Transport for Vision; Identification of New Therapeutic Targets for Blinding Diseases

Dr. Sun’s laboratory studies the molecular mechanism of vitamin A transport for vision and new therapeutic targets for blinding diseases. Vitamin A is essential for vision because it is the precursor for the chromophore of photoreceptor proteins and also plays critical roles in eye development. Plasma retinol binding protein (RBP) is the principal carrier of vitamin A in the blood. Dr. Sun’s laboratory identified the long-sought RBP receptor, which functions simultaneously as a membrane receptor and a membrane transporter that mediates cellular up- take of vitamin A. His laboratory is using a variety of techniques to study this membrane transport system. Dr. Sun’s lab is also identifying new therapeutic targets. Specifically, his lab identified new factors that pro- tect cone photoreceptor cells and is testing these factors in vivo in collaboration with Dr. Xian-Jie Yang’s lab. A second project is studying the newly identified membrane receptors for a factor that has broad therapeutic value in treating diverse cancer types and blinding diseases, such as diabetic retinopathy, ischemia-induced retinopathy, and age-related macular degeneration. In addition to studying the signaling mechanism, Dr. Sun’s lab has developed an innovative screening technique that allows the identification of chemical compounds that specifically target the receptors of this therapeutic factor and mimic its function in vitro and in vivo. These compounds are potential first-in-class medicine to treat major human blinding diseases.

Faculty | Stein Eye Institute 73 Faculty

Gabriel H. Travis, MD Public Service Scientific Advisory Panel Member, Charles Kenneth Feldman Chair in Ophthalmology The Karl Kirchgessner Foundation Professor of Ophthalmology Vision Science Program Grant Reviewer, National Institutes of Health, the Biology and Diseases of the Posterior Eye Study Section Biochemistry of Vertebrate Photoreceptors and Reviewer, Howard Hughes Medical Mechanisms of Retinal Degeneration Institute Investigators Reviewer for many scientific journals Dr. Travis’ laboratory uses biochemi- Still another project in Dr. Travis’ lab- cal and genetic approaches to study oratory concerns the mechanism of the visual cycle and its role in retinal visual-pigment regeneration in cone and macular degenerations. Vision in photoreceptors. Despite the impor- vertebrates is mediated by two types tance of cones, little is known about of light-sensitive cells: rods and cones. how visual pigments are replenished These cells contain light-detecting mol- to permit sustained vision under day- ecules called opsin pigments. Detec light conditions. Recent results from tion of a single light particle bleaches Dr. Travis’ group point to the exis- the opsin pigment. Restoring light sen- tence of a new enzymatic pathway sitivity to a bleached opsin involves an for regenerating visual pigments in enzymatic pathway called the visual cones. His group is currently working cycle. Mutations in the genes for many to purify and clone the enzymes that proteins of the visual cycle cause in- define this new biochemical pathway. herited blinding diseases. One project in Dr. Travis’ laboratory studies the function of a transporter protein in rods and cones called ABCA4. Mutations in the human ABCA4 gene cause recessive Star- gardt macular degeneration and cone- rod dystrophy. Dr. Travis’ group generated mice with a null mutation in this gene. Biochemical analysis of the phenotype in these ABCA4 “knock- out” mice led them to the function of ABCA4 in photoreceptors, and the biochemical etiology of Stargardt disease. This understanding suggested a pharmacological strategy to reverse the biochemical defect in patients with Stargardt disease and age-related macular degeneration. A phase II clinical trial is currently underway to test a drug based on this strategy as a treatment for age-related macular degeneration. Another ongoing project in Dr. Travis’ laboratory characterizes Rpe65, which catalyzes the critical isomerization step in the visual cycle. Previously, Dr. Travis and co-workers identified Rpe65 as the retinoid isomerase.

74 Stein Eye Institute | Faculty Faculty

Irena Tsui, MD Public Service Committee Member, UCLA Women in Assistant Professor of Ophthalmology Medicine and Science Member of the Stein Eye Institute Care Harbor LA Free Clinic Reviewer for many scientific journals

Clinical Vitreoretinal Research

Dr. Tsui’s research focuses on im proving clinical outcomes in patients with retinal diseases. Her areas of interest include retinopathy of prematurity, diabetic retinopathy, ultra-wide field imaging, surgical techniques, and studying patient-centered outcomes in veterans. In addition to providing patient care at the Stein Eye Institute in Westwood, Dr. Tsui also sees patients at the Doheny Eye Center UCLA–Arcadia.

Faculty | Stein Eye Institute 75 Faculty

Federico G. Velez, MD Public Service Vice-Chair, Adult Strabismus Health Sciences Associate Clinical Professor of Ophthalmology Committee, American Association Member of the Stein Eye Institute of Pediatric Ophthalmology and Strabismus Editorial Board Advisory Panel Member, Treatment Strategies—Pediatrics, Strabismus and Childhood Eye Disorders The Cambridge Research Centre Editorial Board Member, Journal of the American Association of Pediatric Dr. Velez’s primary research interest Dr. Velez has recently completed stud- Ophthalmology and Strabismus, is studying the mechanisms of con- ies that apply bioengineering technol and Journal of the Colombian Society genital and acquired forms of stra- ogy to the correction of ocular motil- of Ophthalmology bismus. He has participated in the ity disorders. He has also identified Member, American Academy of development of guidelines for preop- a new ocular motility disorder in pa- Ophthalmology, American Association erative assessment and surgical ap- tients with the human immunodefi- for Pediatric Ophthalmology and Strabismus, Latin American Council of proaches to patients with convergent ciency virus. He provides patient care Strabismus, Latin American Pediatric (esotropia), divergent (exotropia), and at the Stein Eye Institute in West- Ophthalmology Society, Colombian vertical forms of strabismus, and has wood and the Doheny Eye Center Society of Ophthalmology, and developed new techniques to treat UCLA–Orange County. Colombian Society of Pediatric Ophthalmology and Strabismus pediatric patients with eyelid abnormalities and cataracts. Reviewer for many scientific journals

76 Stein Eye Institute | Faculty Faculty

David S. Williams, PhD Public Service NIH Biology of the Visual System (BVS) Professor of Ophthalmology and Neurobiology Study Section Member of the Stein Eye Institute NEI Board of Scientific Counselors Executive Committee, Beckman- Argyros Award in Vision Research Cell Biology of the Retina and Inherited Retinal Disease Scientific Advisory Board Member, Foundation Fighting Blindness Dr. Williams’ laboratory focuses on the Executive Board Member, cell biology of photoreceptor and reti- Sustainability Council of New Zealand nal pigment epithelium cells. His group Co-Chair, Federation of American is especially interested in proteins Societies for Experimental Biology that function in transport and com- (FASEB) Summer Conference on partmentalization within these cells. Biology and Chemistry of Vision These proteins include those that un derlie Usher syndrome and macular degeneration. Translational areas of his research involve gene therapy ex periments aimed at preventing the blindness that ensues from Usher syndrome type 1B and studies on stem cell-derived RPE cells, which may be transplanted into retinas afflicted by macular degeneration.

Faculty | Stein Eye Institute 77 Faculty

Xian-Jie Yang, PhD Public Service Grant Reviewer (US), Ernest G. Herman Chair in Ophthalmology National Institutes of Health; Professor of Ophthalmology National Science Foundation Member of the Stein Eye Institute Grant Reviewer (foreign), Medical Research Council and Wellcome Trust in the United Kingdom; Research Grant Council of Hong Kong; Israel Science Foundation; Biomedical Research Development and Disease Therapy of the Retina Council of Singapore; National Science Foundation of China Dr. Yang’s laboratory studies the mo- Editorial Board Member, Visual lecular and cellular mechanisms un- Neuroscience, Translational Vision Science & Technology, Signal derlying retinal development and Transduction and Targeted Therapy repair. Blinding diseases such as retinitis pigmentosa, geographic atrophy, Reviewer for many scientific journals and glaucoma involve the permanent loss of photoreceptors or retinal ganglion cells. A potential treatment strategy is to supply diseased retinas with protective agents that can prolong neuronal survival. One area of current research focus in the Yang laboratory is to understand how certain growth factors enhance neuronal viability under retinal degeneration conditions. These investigations use genetic and biochemical approaches to dissect cellular events triggered by growth factor treatments in disease models, thus providing insight into clinical application of neuroprotective therapies for patients afflicted with retinal degenerative diseases. Another major research direction of the Yang laboratory is to enable stem cell-based derivation of human retinal organoids in culture and to induce differentiation of retinal neurons, especially retinal ganglion cells. These studies utilize cutting-edge stem cell technologies and apply known developmental regulatory principles to establish in vitro models of human retinogenesis. Out- comes of the research will provide stem cell-based tools to study human retinal differentiation and diseases, and opportunities to develop new thera peutic treatments.

78 Stein Eye Institute | Faculty Faculty

Jie J. Zheng, PhD Public Service Member, Professional Development Professor of Ophthalmology and Education Committee, Member of the Molecular Biology Institute The Association for Research in Vision and Ophthalmology (ARVO) Member of the Jonsson Comprehensive Cancer Center Editorial Board Member, Member of the Stein Eye Institute Cell Communication and Signaling

Therapeutic Development in Ophthalmology

Dr. Zheng’s research is at the inter- The current focus of the laboratory face of biochemistry, computational is to develop proteins and small biology, systems pharmacology, and molecules that can modulate signal drug discovery with an emphasis on transduction pathways, such as Wnt, therapeutic development in ophthal- Hedgehog, BMP, and Hippo pathways, mology. Taking advantage of increas- in an effort to better understand the ing computer capability, Dr. Zheng’s biological functions of these signaling research group finds that the combi- pathways and to explore the thera- nation of experimental and compu- peutic potential of these compounds tational studies gives them a unique and proteins. Aiming to establish new strength, and on the basis of this translational research within the vi- strength, Dr. Zheng’s laboratory has sion research community at UCLA, achieved great successes. the goal of Dr. Zheng’s research is to develop novel therapies for retinal degenerative diseases, glaucoma, and corneal disorders.

Faculty | Stein Eye Institute 79 Faculty Faculty, Doheny Eye Center UCLA

Benjamin B. Bert, MD Vikas Chopra, MD Brian A. Francis, MD, MS Health Sciences Health Sciences Health Sciences Clinical Professor Assistant Clinical Professor Associate Clinical Professor Rupert and Gertrude I. Stieger Charles Stewart Warren and Vision Research Chair Cornea-External Hildegard Warren Endowed Research Chair Director of Glaucoma Services, Ocular Disease and Doheny Eye Center UCLA Refractive Surgery Medical Director, Doheny Eye Center UCLA–Pasadena Medical Director, Doheny Eye Center Dr. Bert provides comprehensive oph- UCLA–Orange County thalmic care and is a subspecialist in Glaucoma cornea/external disease. His areas of Glaucoma expertise include: dry eye/blepharitis, Specializing in glaucoma, Dr. Chopra’s Dr. Francis’ clinical specialties are glau- conjunctivitis, uveitis, acute corneal research activities include advanced coma and complex cataract. His re- injury, and genetic corneal disorders, optic nerve and retinal nerve fiber search activities include: innovative as well as cataract surgery with ad- layer imaging for early glaucoma de- glaucoma surgeries, minimally inva- vanced intraocular lenses and refrac- tection, as well as development and sive glaucoma surgery, novel visual tive surgery. validation of novel parameters for use field techniques, glaucoma diagnostic in anterior segment optical coherence Dr. Bert sees patients at the Doheny and functional imaging, anterior seg- tomography devices as principal in- Eye Center UCLA offices in Orange ment imaging (ultrasound biomicros- vestigator at the Doheny Image Read- County and Pasadena. copy and Fourier domain optical co- ing Center. Dr. Chopra also evaluates herence tomography), and glaucoma laser and surgical techniques for the laser surgery. management of glaucoma. Dr. Francis sees patients at the Doheny Dr. Chopra provides patient care at Eye Center UCLA locations in Arcadia, the Doheny Eye Center UCLA loca- Orange County, and Pasadena. tions in Arcadia and Pasadena.

80 Stein Eye Institute | Faculty Faculty

Gad Heilweil, MD Hugo Y. Hsu, MD Alex A. Huang, MD, PhD Health Sciences Health Sciences Assistant Professor of Ophthalmology Assistant Clinical Professor Associate Clinical Professor Glaucoma Degenerative Retinal Disease Cornea and Dr. Huang’s clinical specialties in- External Diseases Dr. Heilweil’s research activities include glaucoma, minimally invasive clude stem-cell therapy for degenera- Dr. Hsu specializes in corneal infection glaucoma surgery, trabeculectomy, tive retinal disease; retinal and uveal and inflammation, corneal transplanta glaucoma drainage devices, cyclode- drug toxicity; and pharmacokinetics tion, anterior segment reconstruction, struction, and complex cataracts. His of intravitreal drugs. and cataract surgery. His research research activities involve character- interests include corneal and ocular izing post-trabecular meshwork and In addition to providing patient care at infections and ophthalmic antibiotics. scleral changes in glaucoma, optical the Stein Eye Institute in Westwood, coherence tomography visualization Dr. Heilweil also sees patients at Dr. Hsu sees patients at the Doheny of aqueous humor outflow pathways the Doheny Eye Center UCLA loca- Eye Center UCLA locations in Arcadia, in the eye, and angiographic visualiza- tions in Arcadia, Orange County, and Orange County, and Pasadena. tion of aqueous humor outflow in the Pasadena. eye. His goal is to provide the most individual centric care, and through the use of research, develop means to customize glaucoma management and surgery for each patient. Dr. Huang provides patient care at the Doheny Eye Center UCLA–Pasadena.

Faculty | Stein Eye Institute 81 Faculty

Michael S. Ip, MD John A. Irvine, MD Ram Kannan, PhD Professor of Ophthalmology Health Sciences Adjunct Professor of Ophthalmology Clinical Professor Vitreoretinal Disease A. Ray Irvine, Jr., MD, Eye Physiology and Pathology Dr. Ip’s research focuses on the design Chair in Clinical Ophthalmology Dr. Kannan’s research focuses on eye and conduct of clinical trials investigat- Medical Director, physiology and pathology. He cur- ing treatments for diabetic retinopathy, Doheny Eye Center UCLA rently investigates age-related macu- age-related macular degeneration, and lar degeneration, a leading cause of retinal venous occlusive disease. He Cornea and External Diseases blindness in high-resource countries. has served as the national director for Dr. Irvine’s clinical specialties are cor- numerous National Eye Institute fund- nea and external diseases (eg, tumors, ed ophthalmic clinical trials. Addition- infections), anterior segment surgical ally, as director of the Doheny Image consultation, and prosthetic replace- Reading Center, Dr. Ip assists with the ment of the ocular surface ecosystem collection, analysis, and dissemination (PROSE). His research activities focus of important secondary outcomes in on ocular infections. many important clinical trials in the field of ophthalmology. Dr. Irvine provides patient care at the Doheny Eye Center UCLA loca- Dr. Ip sees patients at the Doheny tions in Arcadia, Orange County, and Eye Center UCLA–Pasadena. Pasadena.

The Doheny Eye Center UCLA–Orange County, located at the Orange Coast Memorial Medical Center, provides comprehensive ophthalmology and subspecialty services.

82 Stein Eye Institute | Faculty Faculty

M. Ali Khan, MD Olivia L. Lee, MD Kenneth L. Lu, MD Assistant Professor of Ophthalmology Health Sciences Health Sciences Assistant Clinical Professor Assistant Clinical Professor Vitreoretinal Disease Medical Director, Dr. Khan specializes in the medical Cornea/External Diseases and Doheny Eye Center UCLA–Arcadia and surgical treatment of vitreoretinal Uveitis; Corneal Imaging disease, and his research interests in- Focusing on cornea/external diseases Cataract and clude proliferative vitreoretinopathy, and uveitis, Dr. Lee’s particular inter- Refractive Surgery diabetic retinopathy, and retinal im- est is in inflammatory ocular surface Dr. Lu specializes in cataract and re- aging modalities. disease, corneal melts, pterygia, and fractive surgery, and his research ac- anterior segment complications of tivities are focused in the same areas. Dr. Khan sees patients at the Doheny uveitis. Dr. Lee performs all types of Eye Center UCLA locations in Arcadia, corneal transplants, as well as com- Dr. Lu sees patients at the Doheny Orange County, and Pasadena. plex cataract surgery in uveitic eyes. Eye Center UCLA–Arcadia. Dr. Lee’s research interests are anterior segment imaging applied to the tear film, cornea, and conjunctiva. With her expertise in corneal imaging, a specular microscopy reading center was developed at the Doheny Image Reading Center, where she serves as an investigator. Dr. Lee provides patient care at the Doheny Eye Center UCLA locations in Arcadia, Orange County, and Pasadena.

Faculty | Stein Eye Institute 83 Faculty

Peter A. Quiros, MD Daniel B. Rootman, MD, MS SriniVas R. Sadda, MD Health Sciences Assistant Professor of Ophthalmology Professor of Ophthalmology Associate Clinical Professor Stephen J. Ryan-Arnold and Orbit and Ophthalmic Mabel Beckman Foundation Neuro-Ophthalmology Plastic Surgery Endowed Presidential Chair Specializing in neuro-ophthalmology, Dr. Rootman is an orbit and oph President and Chief Scientific Officer, the clinical specialties of Dr. Quiros thalmic plastic surgery specialist. His Doheny Eye Institute are: optic nerve disease, including op clinical expertise includes Graves dis- tic neuritis and multiple sclerosis; dou- ease, orbital surgery, orbital tumors, Retinal and Macular Diseases ble vision and adult strabismus; eye ptosis, lacrimal disorders, blepharo Dr. Sadda specializes in age-related pain, headache, and idiopathic intra- plasty, blepharospasm, Botox®, cos- macular degeneration, hereditary ret- cranial hypertension; Graves disease; metic dermal fillers, endoscopic eye- inal degenerations, diabetic retinopa- orbital inflammatory syndromes; and brow lift, eyelid surgery, eyelid tumo rs, thy, venous occlusive disease, tele- stroke. Dr. Quiros’ research activities and trauma. Research activities are medicine screening and consultation include idiopathic intracranial hyperten- on developing and refining patient- programs, as well as retinal disease sion, headache, ocular myasthenia gra centered outcome measures for sur- diagnosis and classification. His re- vis, Graves disease, optic neuritis and gical care; randomized clinical trials in search activities include: quantitative, multiple sclerosis, and visual rehabili- surgery, including ptosis, Graves orbi automated retinal image analysis; tation after stroke. Dr. Quiros was the topathy and lacrimal disease; health retinal substructure assessments; ad- principal investigator for the recently economics of eyelid and facial surgery; vanced retinal imaging technologies; completed idiopathic intracranial hyper- sociodemographics of facial trauma; genotype-phenotype correlative stud- tension treatment trial and is currently physiology and pathobiology of ptosis; ies; and vision restoration technolo the principal investigator for the longi- new approaches to surgery; and mea- gies, such as stem cells and pros- tudinal idiopathic intracranial hyperten- surement and assessment in medi- thetic vision. sion treatment trial. Dr. Quiros is also a cal education. member of the Neuro-Ophthalmology Dr. Sadda provides patient care at the Researcher and Disease Investigators Dr. Rootman sees patients at the Stein Doheny Eye Center UCLA locations Consortium (NORDIC) and is the local Eye Institute in Westwood, as well in Arcadia and Pasadena. NORDIC director. as the Doheny Eye Center UCLA locations in Orange County and Pasadena. Dr. Quiros provides patient care at the Doheny Eye Center UCLA locations in Orange County and Pasadena.

84 Stein Eye Institute | Faculty Faculty

Alfredo A. Sadun, MD, PhD Deming Sun, MD James C. Tan, MD, PhD Professor of Ophthalmology Professor of Ophthalmology Associate Professor of Ophthalmology Flora L. Thornton Endowed Chair Mary D. Allen Chair in Vision Research in Vision Research Glaucoma Vice Chairman of Ophthalmology, Research Scientist Dr. Tan is a dual fellowship-trained Doheny Eye Center UCLA Dr. Sun is a researcher whose pri- glaucoma specialist. He treats the mary areas of investigation include full spectrum of cataract and glauco- Neuro-Ophthalmology uveitis, autoimmune diseases, optic ma conditions, ranging from mild to Clinical specialties of Dr. Sadun include neuritis, animal disease models, and complex. His treatments and surger- neuro-ophthalmology, optic nerve, op- T-cell biology. ies focus on safe and effective out- tic neuropathies (eg, posterior ische comes using advanced techniques. mic optic neuropathy, anterior ische Dr. Tan has authored over 100 scien- mic optic neuropathy, and traumatic tific papers, abstracts, book chapters, optic neuropathy), Leber hereditary and books. His glaucoma research optic neuropathy, toxic and nutrition- addresses advanced imaging, molec- al optic neuropathies, vision in Alzhei- ular pathogenesis, drug development, mer’s, AIDS, and other central ner- and surgical techniques. He has re- vous system disorders. Dr. Sadun’s ceived awards from the National Insti- research activities focus on human tutes of Health, Research to Prevent visual neuroanatomy; retinal ganglion Blindness, and the American Glauco- cell degeneration and regeneration; ma Society. axon populations in the human optic Dr. Tan provides patient care at the nerve in development, aging, and dis- Doheny Eye Center UCLA locations ease; and mitochondrial impairments in Arcadia and Pasadena. as a cause of optic neuropathy and other forms of neurodegeneration. Dr. Sadun sees patients at the Do heny Eye Center UCLA–Pasadena.

Faculty | Stein Eye Institute 85 Faculty Stein Eye Institute Members Based at Other Sites

James W. Bisley, PhD Antoni Ribas, MD Associate Professor of Neurobiology Professor of Medicine, Surgery, and and Psychology Molecular and Medical Pharmacology Member of the Stein Eye Institute Member of the Stein Eye Institute Member of the Brain Research Institute Dr Ribas is a physician-scientist who conducts laboratory and clinical re- Cognitive Processing of search in malignant melanoma, focus- Visual Information ing on gene engineered adoptive cell transfer (ACT) therapies, anti-CTLA4 Dr. Bisley’s research revolves around antibodies, anti-PD-1 antibodies, and understanding the neural mechanisms BRAF and MEK inhibitors. underlying the cognitive processing of visual information. These cognitive processes include visual perception, Dario L. Ringach, PhD visual memory, and visual attention. His recent work has focused on how Professor of Neurobiology and Psychology, the responses of neurons in the pos- Biomedical Engineering Program terior parietal cortex are involved in the allocation of visual attention to Member of the Stein Eye Institute neurons in visual cortices and how they guide eye movements in goal- Visual Perception directed visual search. and Neurophysiology Dr. Ringach’s research focuses on the relationship between eye move- Patrick T. Dowling, MD, MPH ments and visual perception, as well Chair, UCLA Department of as how motor planning and execution, Family Medicine such as reaching, grasping, navigat- The Kaiser Endowed Professor of ing, and adjusting body posture, is Community Medicine influenced by visual information and impaired vision. In collaboration with Member of the Stein Eye Institute a team of neurosurgeons at UCLA, Dr. Ringach’s laboratory is also re- Health Care Policy and Access cording the brain activity of patients for Underserved Populations with epilepsy who are undergoing clin- Dr. Dowling has received grant fund- ical evaluation for surgical treatment, ing for more than 30 years to link med- shedding new light into the process- ical education to underserved neigh- es involved in object recognition and borhoods thereby providing access perception. to care. Further, he has worked with Dr. Anne Coleman and the Care Har- bor program to provide free medical, dental, and eye care to low-income families and the medically indigent of Los Angeles.

86 Stein Eye Institute | Faculty Faculty Professional Research Series

Christian Altenbach, PhD Barry L. Burgess, BS Rajendra Gangalum, PhD Research Ophthalmologist Research Specialist Assistant Research Specialist

Structure and Function Degenerative Retinal Function and Regulation of Rhodopsin Disease Research of Small Heat Shock The membrane protein rhodopsin is Mr. Burgess provides research sup- Protein aB-crystallin a critical first step in visual transduc- port for the Photoreceptor/RPE Cell in Health and Disease tion, converting light energy into a Biology Laboratory of Dr. David Wil- Dr. Gangalum’s research seeks to chemical form in the photoreceptor liams. Research interests include pro- gain understanding of the physiologi- cell of the eye. To understand this production of differentiated RPE cells cal function of aB-crystallin in the de- cess on a detailed molecular level, Dr. from human stem cell precursors and veloping ocular lens and non-ocular Altenbach is using site-directed spin developing in vitro models of oxida- tissues. aB-crystallin has been shown labeling and electron paramagnetic tive stress involved in degenerative to associate with pathologies such as resonance spectroscopy to study the retinal disease progression. cataracts, cancer, age-related macu- structure of rhodopsin in the absence lar degeneration, and various neuro of light, as well as the changes in degenerative diseases. structure caused by light. Jeremy D. Cook, PhD Assistant Project Scientist Sheyla Gonzalez, PhD Navid Amini, PhD Regulation of the Visual Cycle Assistant Project Scientist Assistant Research Ophthalmologist Dr. Jeremy Cook is studying the role of peropsin, the non-visual opsin, in Limbal Stem Cells Biomedical Imaging and retinal pigment epithelial cells. This Dr. Gonzalez´s research aims to im- Mobile Health protein appears to regulate the me- prove the ex vivo expansion of limbal Dr. Amini develops signal processing tabolism of visual retinoids in a light- epithelial stem cells (LSCs) by mod- and machine learning techniques in dependent fashion. ulating Notch signaling in individuals ophthalmic research, and he utilizes suffering from limbal stem cell defi- these techniques in quantitative as- ciency (LSCD). The identification of sessment of major ocular diseases, Rikard Frederiksen, PhD niche factors could help to improve including glaucoma. He also investi- Assistant Research Ophthalmologist the in vitro production of LSCs for gates the behavior of nonvisual sen- transplantation. sory systems and the effects of low Adaptation vision on activities of daily living. Dr. Frederiksen’s main research inter- Sonia Guha, PhD est is adaptation, specifically how the Assistant Project Scientist Michael Bridges, PhD rods and cones in the retina adapt to different light intensities. Assistant Project Scientist Unraveling New Therapeutic Targets for Ocular Albinism Paramagnetic Resonance Dr. Guha studies genes that may be Methodologies associated with the misrouting of ret- Dr. Bridges’ research in the laborato- inal ganglion cell (RGC) axons at the ry of Dr. Wayne Hubbell is centered brain’s optic chiasm in individuals af- on the development and application fected with X-linked ocular albinism of new pulsed electron paramagnet- type 1 (OA1). This disease is also ic resonance methodologies. Protein characterized by hypopigmentation conformational dynamics and struc- and presence of macromelanosomes tural relaxation are his central focus in the RPE. How the reduced pigmen- with the goal of characterizing the tation of OA1 RPE exerts its effects timescales and motional amplitudes on the RGCs to influence the misrout- of functional activation. ing of their axons at the optic chiasm remains unsolved, and Dr. Guha’s findings have the potential to unravel new therapeutic targets for OA1.

Faculty | Stein Eye Institute 87 Faculty

Joanna J. Kaylor, PhD Anna Matynia, PhD Alberto C. Ruiz-Morales Assistant Project Scientist Associate Research Ophthalmologist Research Specialist

Visual Chromophore Dr. Matynia’s research investigates Visual Cycle Regeneration in the the mechanisms underlying photo Mr. Ruiz, a molecular biologist, is di- Retina of the Eye allodynia, a condition in which normal rectly involved in the cloning and char- levels of light produce or enhance oc- Dr. Kaylor has discovered that light acterization of enzymes critical for the ular or headache pain. Using behav- plays a vital role in regeneration of proper functioning of the visual cycle. ioral, molecular, genetic, and cellular visual chromophore in the retina. She Currently, Mr. Ruiz is analyzing genes, approaches, the laboratory focuses recently identified a non-enzymatic such as ARMS2 and HTRA1, which on corneal, retinal, and central mech- process that generates visual pig- are thought to be involved in age- anisms from dry eye injury, achroma- ment in photoreceptor membranes related macular degeneration. topsia, and migraine, respectively. in light. Her research now focuses on the function of retinal G-protein Alejandra Young, PhD coupled receptor (RGR). Johan Pahlberg, PhD Assistant Project Scientist Assistant Project Scientist Jacky M. K. Kwong, PhD Ocular Albinism Research Ophthalmologist Optimal Processing of Sensory Signals in the Retina Dr. Young’s research is focused on the study of the molecular mech- Degeneration of Dr. Pahlberg is interested in how noise anisms that cause ocular albinism Retinal Ganglion Cells in the mammalian retina is mitigated type 1 (OA1), a disease caused by and Neuroprotection to allow for highly sensitive night vi- mutations in the OA1 gene and char- sion. The research is focused on how Dr. Kwong identifies novel neuropro- acterized by hypopigmentation of the rod photoresponses are processed tective and regenerative therapies for retinal pigment epithelium and abnor- and parsed into the retinal circuitry, glaucoma that preserve and restore mal crossing of the optic axons at the the correlations between retinal phys- the nerve cells. He utilizes animal optic chiasm. In addition, she investi- iology and behavior for low light level models related to optic nerve injury gates the potential therapeutic use of vision, and thus, how sensory systems and glaucoma to understand the pro- engineered human embryonic stem increase their signal-to-noise ratio and gression of retinal ganglion cell de- cell-derived extracellular vesicles for the information encoded in the neu- generation, and pharmacologic tech- the treatment of ocular albinism. ral pathway. niques and functional assessments to evaluate therapies.

Qihua Le, MD, PhD Visiting Assistant Project Scientist

Diagnostic Potential of Ocular Imaging in the Diagnosis of Limbal Stem Cell Deficiency Dr. Le’s research aims to study the diagnostic potential of a newly developed ocular imaging technique, in vivo confocal microscopy, and anteri- or segment optical coherence tomography, in the diagnosis of limbal stem cell deficiency.

88 Stein Eye Institute | Faculty Faculty Professional Clinical Series

Laura Bonelli, MD Rachel Feit-Leichman, MD Associate Physician Diplomate Associate Physician Diplomate

Neuro-Ophthalmology Cataract Surgery Dr. Bonelli provides clinical supervi Dr. Feit-Leichman divides her time sion to resident physicians at the between supervising residents and University Ophthalmology Associates providing patient care at the Stein and teaches medical students during Eye Institute’s Urgent Care Clinic, and their ophthalmology surgical subspe- teaching cataract surgery and over- cialties clinical rotation. She is collab- seeing residents at the ophthalmol- orating on a study to learn and better ogy clinic of the Harbor-UCLA Med- understand giant cell arteritis (GCA), ical Center. Dr. Feit-Leichman is also an inflammation of the lining of the ar- active in striving to improve patient teries. GCA frequently causes blurred access to eye care in the greater Los Uday Devgan, MD, FACS, or double vision, and if left untreated, Angeles County Healthcare System. FRCS may result in loss of vision. She is also a co-investigator for the National Clinical Professor of Ophthalmology Eye Institute-sponsored study of idio- Batool Jafri, MD pathic intracranial hypertension. Associate Physician Diplomate Chief of Ophthalmology, Olive View-UCLA Medical Center Assistant Clinical Professor of Ophthalmology Dr. Devgan is a cataract and re- Eli L. Chang, MD fractive surgery specialist who Associate Physician Diplomate Cornea/External Disease/ has taught ophthalmic surgery in Refractive Surgery more than 50 countries. He has Reconstructive Surgery been actively involved in resident Dr. Jafri provides patient care as well teaching for nearly two decades, Dr. Chang is a specialist in ophthal- as supervision to resident physicians and he has mentored more than mic plastic, orbital, and reconstructive and cornea fellows. Her focus is med- 130 residents over the course of surgery. He specializes in treatment ical and surgical treatment of diseases thousands of ocular surgeries, in- of diseases of the eyelids, tear drain- of the cornea, external disease, and cluding advising former residents age system, and orbit. His expertise refractive conditions like near and far after the culmination of their train- includes eyelid cancers, thyroid eye sightedness. She also provides gen- ing. Passionate about teaching disease, fractures, and trauma of the eral ophthalmic care and offers cata- the next generation of ophthal- area surrounding the eye, tearing, and ract surgery with premium intraocular mologists, Dr. Devgan has been cosmetic surgery of the eyelids. lens implants. honored with the ophthalmology Faculty Teaching Award an un- precedented four times. Melissa W. Chun, OD Associate Clinical Professor of Ophthalmology Director of the UCLA Vision Rehabilitation Center

Vision Rehabilitation Dr. Chun’s clinical research interests are in vision rehabilitation outcomes and training techniques that maximize visual function. She is a member of the Low Vision Research Network, a nationwide collaboration of low vision specialists for multicenter clinical studies. She is also involved in visual outcome measures for various clinical studies on macular degeneration.

Faculty | Stein Eye Institute 89 Faculty

Monica R. Khitri, MD Tania Onclinx, MD Ronald J. Smith, MD Associate Physician Diplomate Associate Physician Diplomate Associate Physician Diplomate Clinical Instructor of Ophthalmology Associate Clinical Professor Pediatric Ophthalmic of Ophthalmology Diseases and Strabismus Urgent Care and Dr. Khitri specializes in the evaluation Clinical Supervision Objective Assessment of Surgical Technique and treatment of pediatric ophthalmic Dr. Onclinx attends at the Urgent Care and Training diseases, including pediatric cataracts, Walk-In service at the Stein Eye Insti- nasolacrimal duct obstructions, am- tute. She teaches resident physicians Dr. Smith’s research interest is the blyopia, and retinopathy of prematu- and medical students at the Univer objective assessment of surgical tech- rity. She also treats and operates on sity Ophthalmology Associates during nique and development of evidence- strabismus in both children and adults. their subspecialty clinical rotation. She based surgical training for residents Dr. Khitri sees patients at the Doheny also provides clinical supervision to to improve patient care. In addition Eye Center UCLA locations in Arca- resident physicians at Ronald Reagan to teaching residents at the Veterans dia and Pasadena. She also teaches UCLA Medical Center and UCLA Med- Affairs Greater Los Angeles Health- residents and fellows at Harbor-UCLA ical Center, Santa Monica. care System and in the UCLA Micro- Medical Center, where she is chief of surgery Laboratory, Dr. Smith provides the pediatric ophthalmology service. cornea and comprehensive eye care Susan S. Ransome, MD to patients at the Stein Eye Center– Santa Monica. Phillip Le, MD, PhD Associate Physician Diplomate Associate Physician Diplomate Clinical Instructor of Ophthalmology Laura A. Syniuta, MD HIV and Diabetic Retinopathy Retinal and Macular Diseases Associate Physician Diplomate Dr. Le is a comprehensive ophthalmol- Dr. Ransome is participating in a ogist who specializes in retinal and clinical research study involving HIV- Pediatric Ophthalmology macular diseases. He sees patients infected patients who have diabetes and Strabismus to see whether there is increased risk at the Doheny Eye Center UCLA– Dr. Syniuta completed her fellowship of development or progression of dia Pasadena. training in pediatric ophthalmology betic retinopathy when subjects are and strabismus at the Stein Eye Insti- treated for abdominal lipodystrophy tute in 1999. With children’s eye and with Egrifta (tesamorelin). Mitra Nejad, MD learning disorders being her passion, Associate Physician Diplomate she sees patients at UCLA’s Stein Clinical Instructor of Ophthalmology Meryl L. Shapiro-Tuchin, MD Eye Center in Santa Monica and has staffed UCLA’s Mobile Eye Clinic Associate Physician Diplomate Comprehensive since 2011. Assistant Clinical Professor Ophthalmology of Ophthalmology Dr. Nejad practices comprehensive Co-Director of the Ophthalmology Victoria Yom, MD ophthalmology at the Stein Eye Insti- Inpatient Consultation Service Associate Physician Diplomate tute and the Stein Eye Center–Santa Monica. Her practice involves general Comprehensive ophthalmic care, as well as cataract Ophthalmology and refractive surgery. In addition, LECTURER Dr. Nejad teaches UCLA medical stu- Dr. Shapiro-Tuchin provides clinical supervision to resident physicians. She dents and residents at the Stein Eye Kathleen L. Boldy, VMD Institute, as well as supervising resi- functions as Co-Director of the Oph- dent cataract surgery at Harbor-UCLA thalmology Inpatient Consultation Ser- Lecturer in Ophthalmology Medical Center. vice, assisting resident physicians in their evaluation of inpatients admitted to the Ronald Reagan UCLA Medical Center and the UCLA Medical Center, Santa Monica.

90 Stein Eye Institute | Faculty Faculty Stein Eye Institute Emeritus Faculty

Dean Bok, PhD Barry A. Weissman, OD, PhD Dolly Green Chair of Ophthalmology Professor of Ophthalmology Emeritus Professor of Ophthalmology Emeritus (Active Recall) Marc O. Yoshizumi, MD Distinguished Research Professor of Neurobiology Professor of Ophthalmology Emeritus Member of the Member of the Stein Eye Institute Brain Research Institute Member of the Stein Eye Institute

Gordon L. Fain, PhD Distinguished Professor of the Departments of Integrative Biology/ Physiology and of Ophthalmology (Active Recall) Member of the Stein Eye Institute

Michael O. Hall, PhD Professor of Ophthalmology Emeritus Founding Member of the Stein Eye Institute

Robert S. Hepler, MD Professor of Ophthalmology Emeritus (Active Recall) Founding Chief of the Neuro-Ophthalmology Division Member of the Stein Eye Institute

Joseph Horwitz, PhD Distinguished Professor of Ophthalmology (Active Recall) Member of the Stein Eye Institute

Allan E. Kreiger, MD Professor of Ophthalmology Emeritus (Active Recall) Founding Chief of the Retina Division

Bradley R. Straatsma, MD, JD Professor of Ophthalmology Emeritus Founding Chairman of the Department of Ophthalmology Founding Director of the Stein Eye Institute

Faculty | Stein Eye Institute 91 92 Stein Eye Institute | Faculty Programs Patient Care Services Patient Care Services

he Institute’s program of care Faculty Consultation Service Inpatient Consultation Tfor patients encompasses the Service full range of eye diseases. Nation Institute faculty members provide ally and internationally renowned direct consultation and treatment, The Ophthalmology Inpatient Con faculty, along with highly skilled clin including emerging therapies, to pa sultation Service, operating 24 hours ical fellows and physician residents, tients through the Ophthalmology a day through the Ronald Reagan provide integrated consultation and Faculty Consultation Service. Faculty UCLA Medical Center and UCLA treatment, including new diagnos members have extensive, advanced Medical Center Santa Monica, pro training in ophthalmic subspecialties, vides ophthalmic consultation and tic and therapeutic procedures that providing referring physicians and pa treatment to pediatric and adult pa have been made available through tients with a valuable resource for tients who are admitted to the hospital recent scientific advances. Skilled special eye problems. for inpatient care. optometrists, orthoptists, techni cians, and nurses support institute Led by Drs. Laura Bonelli and Meryl ophthalmologists in their efforts. L. Shapiro-Tuchin, the consultation Care is delivered in distinctive sub team consists of physician-residents at the UCLA Stein Eye Institute, with specialty treatment centers, service subspecialty coverage provided as areas, and clinical laboratories, as needed by UCLA Department of Oph well as in specially equipped oph thalmology faculty. thalmic surgical suites. In addition, the Stein Eye Center–Santa Monica and the Doheny Eye Center UCLA offer premier eye care services in convenient neighborhood locations.

Find detailed information about our locations, including providers and services offered, by going to: www.uclahealth.org/eye/ our-locations.

From the westside to the eastside and south to Orange County, access to the UCLA Department of Ophthalmology physicians you know and trust has never been easier.

UCLA Department of Ophthalmology Los Angeles and Beyond

94 Stein Eye Institute | Programs Patient Care Services

Six operating suites, a sterile process Stein Eye Institute, Westwood Surgical Services ing area, procedure treatment units, 100 Stein Plaza, UCLA Ophthalmic surgery of every kind, and postoperative areas serve all Los Angeles, CA 90095 from cataract extraction to removal ophthalmic specialties, including ret Referral Service: (310) 825-5000 of ocular and orbital tumors, is per ina, glaucoma, cataract, strabismus, Emergency Service: (310) 825-3090 formed in the Institute’s dedicated cornea, and oculoplastics. In addition, After-Hours Emergency Service: operating rooms. Additionally, laser there are three procedure rooms for (310) 825-2111 vision-correction surgeries, such as physicians to perform minor laser laser-assisted in situ keratomileusis treatments and ophthalmologic sur (LASIK) and certain aesthetic and gical procedures. Stein Eye Center– retinal laser surgeries and injection Santa Monica procedures, are performed in desig The Stein Eye Center–Santa Monica, nated outpatient procedure rooms. Comprehensive Ophthalmology under the direction of Dr. Colin A. Mc- Faculty members perform surgical Cannel, offers the world-renowned procedures according to their specific Comprehensive and subspecialty eye comprehensive and subspecialty eye ophthalmic specialty. They are joined care in all medical and surgical areas care of the Stein Eye Institute at a by other medical specialists, including of ophthalmology is offered at the convenient location in Santa Monica. anesthesiologists, nurses, and tech Stein Eye Institute through the ser Established in 2011, the Stein Eye nicians to ensure the highest quality vice formally known as University Center–Santa Monica features well- preoperative and postoperative care. Ophthalmology Associates. Dr. John equipped exam rooms, an optical shop, The award-winning Edie & Lew D. Bartlett is medical director, and on-site parking for easy access, and Wasserman Building houses the In ophthalmologists who are members testing facilities offering a wide range stitute’s expanded surgery center, of the UCLA Medical Group staff of examinations, including visual field, which enables the Stein Eye Institute the practice. corneal mapping (corneal topography), to provide a greater number of surgi intraocular lens measurement, fluores cal services to patients in need. cein angiography, spectral domain opti cal coherence tomography, and other diagnostic retinal imaging techniques.

Nearly all the evaluation, diagnosis, testing, and treatment services avail able at the Stein Eye Institute in Westwood are offered at the Stein UCLA Department of Ophthalmology Eye Center–Santa Monica by experts Summary of Patient Care Statistics in retinal disorders, corneal disorders, glaucoma, neuro-ophthalmology, and 2016–2017 2017–2018 laser refractive surgery. For surgeries Faculty Consultation Service and seldom-needed tests requiring Patient visits 142,535 149,771 specialized laboratories, patients can Comprehensive Ophthalmology be referred to the Institute’s main fa Patient visits 22,380 24,223 cility in Westwood.

Inpatient Consultation Service Stein Eye Center–Santa Monica Patient evaluations 1,098 985 1807 Wilshire Boulevard, Suite 203 Clinical Laboratories Santa Monica, CA 90403 Procedures 75,139 83,122 Telephone: (310) 829-0160 Fax: (310) 829-0170 Surgery Services Number of procedures1 33,617 34,446 Intravitreal Injections 12,164 12,476

Mobile Eye Clinic Number of patients seen 26,184 17,646 Ocular abnormalities 17% 31% Number of trips 1,212 789

1Includes lasers

Programs | Stein Eye Institute 95 Patient Care Services

Doheny Eye Center UCLA– Doheny Eye Center UCLA– Doheny Eye Center UCLA Orange County Pasadena The UCLA Department of Ophthal The Doheny Eye Center UCLA– The Doheny Eye Center UCLA– mology and the Doheny Eye Institute Orange County opened on May 15, Pasadena, which opened on July 1, formed a historic affiliation in 2014, 2014, in the Orange Coast Memorial 2014, serves as the primary hub of the and patient access to eye care was Medical Center, broadening the reach Doheny Eye Center UCLA. Located immediately broadened across Los of the UCLA Department of Ophthal on the second floor of the Hunting Angeles and into Orange County, mology south to Orange County. ton Pavilion, the Doheny Eye Center with the opening of three Doheny UCLA–Pasadena provides expanded Recently renovated, the Orange Eye Center UCLA locations: Arcadia, vision care services and clinics devot County location, overseen by Med Orange County, and Pasadena. The ed to retina and cornea; comprehen ical Director , Doheny and Stein Eye Institutes share Dr. Brian A. Francis sive ophthalmology and oculoplastics; offers comprehensive ophthalmolo a long tradition of excellence, and neuro-ophthalmology; and glaucoma. gy, as well as glaucoma, retina, cor through this partnership, the respec Each subspecialty clinic has dedi nea, neuro-ophthalmology, pediatric, tive strengths that gained each Insti cated, state-of-the-art diagnostic laser and uveitis subspecialty services. The tute an international reputation have suites, as well as in-office procedure Doheny Eye Center UCLA–Orange been combined. The board-certified rooms. More complex procedures are County includes 12 exam rooms, ded Doheny ophthalmologists that pa performed at the Huntington Pavilion icated diagnostic equipment, and invit tients and referring physicians know Surgical Suites, which are located on ing patient areas. and trust are now members of the the building’s third floor. UCLA Department of Ophthalmology. Doheny Eye Center UCLA– The Doheny Eye Center UCLA is un The Huntington Pavilion is home to a Orange County wide variety of medical practitioners, der the supervision of Vice Chairman Orange Coast Memorial which provides physicians with ease Dr. Alfredo A. Sadun and Medi- Medical Center of referral for patients requiring spe cal Director Dr. John A. Irvine. Dr. 18111 Brookhurst St., Suite 6400 cialized eye care and provides pa SriniVas R. Sadda is the president and Fountain Valley, CA 92708 tients with the added convenience chief scientific officer of the Doheny Telephone: (714) 963-1444 of seeing their doctors and having Eye Institute. Fax: (714) 963-1234 any necessary services all in one lo Doheny Eye Center UCLA– cation. The Medical Director of the Arcadia Doheny Eye Center UCLA–Pasadena is Dr. Vikas Chopra. As Medical Director of the Doheny Eye Center UCLA–Arcadia, Dr. Kenneth L. Doheny Eye Center UCLA–Pasadena Lu oversees a renovated office that Huntington Pavilion includes 12 exam rooms, dedicated 625 S. Fair Oaks Blvd., 2nd Floor diagnostic equipment, and attractive Pasadena, CA 91105 patient areas. The Center provides Telephone: (626) 817-4747 comprehensive ophthalmology, and Fax: (626) 817-4748 nearly all subspecialty services, includ ing glaucoma, retina, and cornea. The Doheny Eye Center UCLA– Arcadia, which opened April 1, 2014, serves patients in the broader Arcadia region and San Gabriel area, expand ing the UCLA Department of Oph thalmology’s reach in Los Angeles County. The Arcadia Center is easily accessible from two freeways and provides on-site, free parking.

Doheny Eye Center UCLA–Arcadia 622 W. Duarte Road, Suite 101 Arcadia, CA 91007 Telephone: (626) 254-9010 Fax: (626) 254-9019

96 Stein Eye Institute | Programs Research and Treatment Centers

he Research and Treatment of facial aging, surgical healing, and research among faculty and inves TCenters provide subspecialty on developing new techniques for tigators from various UCLA depart care from faculty physicians who aesthetic surgery. Center physicians ments and other institutions around are actively involved in related re have pioneered minimal incision sur the world to advance knowledge re search, enabling emerging and ex gical techniques to enhance the nor lated to the causes and prevention of mal function and appearance of the specific eye diseases. perimental treatment options to be eyes and face, and often receive re developed for a gamut of eye disor ferrals for complex and re-operative UCLA Mobile Eye Clinic ders. In addition to comprehensive plastic surgery cases. treatment, the centers provide both For more than 40 years, the UCLA Mobile Eye Clinic has supported pa patients and physicians with expert tient care and screening programs in diagnostic and consultation services Center for Community neighborhoods where poverty and Outreach and Policy for diseases that are difficult to iden- vision disabilities intersect. The dedi tify and treat. Ophthalmology fac The Stein Eye Institute’s Center for cation and hard work of UCLA Mobile ulty work closely with other spe Community Outreach and Policy, un- Eye Clinic ophthalmologists, techni cialists, both within the Stein Eye der the direction of Dr. Anne L. cians, and volunteers have touched Institute and in other UCLA clinical Coleman, is dedicated to the prin the lives of hundreds of thousands departments, to create a multidis ciple that all individuals deserve the of individuals. ciplinary team customized for each best vision attainable. Building upon The UCLA Mobile Eye Clinic, a 39- the Institute’s long tradition of com patient’s unique medical needs. foot-long bus specially outfitted with munity service and leadership at the eye examination equipment, is sup interface of ophthalmology and public Learn more about our research ported by charitable contributions to health, the Center conducts vital re and academic Centers at: www. the Stein Eye Institute. The UCLA search in public-health ophthalmology uclahealth.org/eye/academic- Mobile Eye Clinic’s staff of trained through the UCLA Center for Eye Epi centers. ophthalmic personnel provides gen demiology and provides high-impact eral eye care to over 25,000 under community-based services, such as served adults and children annually the UCLA Mobile Eye Clinic. throughout Southern California. Ser Aesthetic Center vices include vision screening, oph UCLA Center for thalmic examination and refraction, The Aesthetic Center, under the di Eye Epidemiology rection of Dr. Robert Alan Goldberg, diagnosis of potential or existing eye The UCLA Center for Eye Epidemiol provides services to patients who are disorders, treatment of some ocular ogy was established in 1997 to pro interested in enhancing their appear diseases, and appropriate referral of mote interdisciplinary investigations ance through aesthetic surgery. Dr. patients who need additional care. into blinding diseases of public health Daniel B. Rootman also sees pa importance. It is supported by private tients. Established in 1998, the Cen donations, including an endowment Center to Prevent ter has earned a reputation for high established by The Ahmanson Foun Childhood Blindness quality, individualized care delivered dation. The Center maintains and im by surgeons trained in both ophthal proves vision health through public The Center to Prevent Childhood mic and plastic surgery. health research and intervention, and Blindness, under the direction of Dr. Sherwin J. Isenberg, is committed Surgical services include upper and serves as a coordinating body for ex to reducing pediatric blindness. UCLA lower eyelid blepharoplasty, endo panding and sharing information. physicians and basic scientists, in scopic forehead lifting, endoscopic Center members have expertise in ep cluding Drs. Gary N. Holland, Ste- midface surgery, lifting of the neck idemiology, biostatistics, health policy, ven Nusinowitz, and Irwin Weiss, and face, liposuction, fat transfer, public health, and international health. collaborate on research, education, and skin treatment, as well as dermal Members draw on their diverse back and patient care programs designed filler and other cosmetic injections to grounds and complementary skills to to increase awareness and help treat smooth facial lines. Minimally invasive promote an understanding of issues pediatric blindness. Significant em approaches are utilized to provide the related to vision health as it affects phasis is on the development and optimal aesthetic result. A major goal individuals, communities, and society. evaluation of ophthalmic medical and of the Center is to conduct research The Center encourages collaborative surgical options for children. focused on improving understanding

Programs | Stein Eye Institute 97 Research and Treatment Centers

Center members are developing a current stem cell studies and pursues The specialty lenses that are avail- new noninvasive method of mea new research programs to diagnose, able through the Contact Lens Cen suring blood gases from the surface treat, and ultimately cure and prevent ter include rigid gas permeable con of the eye, which may be critical in blinding eye diseases. tact lenses, multifocal contact lenses, preventing retinopathy of prematurity, hybrid lenses, scleral lenses, custom a leading cause of blindness in pre soft lenses, soft lenses for irregu mature newborns. In another avenue Clinical Research Center lar corneas, prosthetic soft lenses, of research, the Center developed pediatric aphakic lenses, and adult The UCLA Department of Ophthalmol an extremely inexpensive antiseptic aphakic lenses. ogy Clinical Research Center (CRC) solution to treat pediatric corneal in was established in 1998 to provide Dr. Shibayama’s clinical research is fections in developing areas of the core support to faculty members who focused on keratoconus and scler world and completed a study show are conducting patient-based research al lenses for the treatment of ocu ing its effectiveness in treating cor studies. This support involves vital, lar surface disease. A large majority neal ulcers that now blind more than behind-the-scenes activities that fa of her patients require custom con 400,000 children worldwide. A sec cilitate the clinical research process. tact lenses and are referred by cor- ond study, which evaluated the solu Dr. Gary N. Holland serves as Direc neal specialists. tion’s effectiveness in treating fungal tor of the CRC working with full-time corneal infections, a major cause of administrator, Ms. Ellen Pascual, and pediatric blindness in tropical coun a Board of Directors composed of Diabetic Eye Disease and tries, has shown promise in treating Department of Ophthalmology faculty Retinal Vascular Center the milder fungal infections. members. The CRC has an in-house Under the direction of Dr. Steven D. statistician, Fei Yu, PhD. CRC staff , the Diabetic Eye Disease members interact with granting agen- Schwartz Center for Regenerative and Retinal Vascular Center provides cies and government regulatory bod Medicine in Ophthalmology diabetic patients with comprehensive ies, assist with the preparation of grant ophthalmic care. Established more Representing a milestone in the thera applications, participate in the design than a decade ago, the Center has peutic use of stem cells, in 2011, Stein and management of clinical studies, contributed significantly to the un Eye Institute clinician-scientists suc and perform data collection and analy derstanding, treatment, and preven cessfully transplanted the first human sis functions for investigators at both tion of diabetic eye disease. Current embryonic stem-cell-derived retinal the UCLA Stein Eye Institute and the focus is on innovation in technolo pigment epithelial cells into the eyes Doheny Eye Institute. gies and techniques that expand the of legally blind patients with Stargardt Institute faculty members are current standard of treatment, such as drugs disease and dry macular degeneration. ly conducting over 80 clinical research and pharmacotherapeutic strategies, The Center for Regenerative Medicine studies (listed in the Appendices). new lasers and laser strategies, re in Ophthalmology (CRMO), under the Patients can volunteer to participate finement of microsurgical techniques co-direction of Drs. Sophie X. Deng in studies that contribute to a better specific to diabetic eye diseases, and and Gabriel H. Travis, is building understanding of ocular disorders or nontraditional treatment approaches. upon these efforts, using stem cells that evaluate new, potentially better The Center’s treatment philosophy is for the treatment of corneal disorders treatments for various diseases of based upon the systemic nature of and retinal degenerative diseases. The the eye. diabetes. Patient care is coordinated CRMO fosters collaboration between with other UCLA departments to ad basic scientists and clinicians, includ dress the special needs of diabetics ing Drs. Debora Farber, Jean-Pierre Contact Lens Center that lie outside the field of ophthal Hubschman, Steven D. Schwartz, The Contact Lens Center, under the mology. Center treatment interven and Xian-Jie Yang, to translate ad supervision of Dr. Vivian Phan Shi- tions include pharmacotherapy, laser vances in basic science research into bayama, serves patients with all and ophthalmic surgery. Recognizing new and improved clinical therapies. ophthalmic diagnoses that can be the special care needed for diabetics Many of the blinding eye diseases, treated with contact lenses. The Cen in any surgical situation, Center physi including glaucoma, macular degen ter’s primary focus is on customized cians perform all eye surgeries for dia eration, and corneal diseases, are specialty lenses that visually rehabili betics, including those specific to the due to the loss of functional tissue. tate conditions, such as keratoconus, disease, as well as vitrectomy, cata The development of effective and corneal transplants, corneal scarring, ract surgery, and retinal reattachment. safe individualized stem-cell-based postrefractive surgery ectasia, ocular therapies relies on robust basic sci surface disease, and aphakia. Dr. Shi ence, as well as translational and clin bayama also prescribes contact lens ical research. The CRMO supports es to address farsightedness, near sightedness, and presbyopia.

98 Stein Eye Institute | Programs Research and Treatment Centers

exudative or wet form of macular dis Eye Trauma and Glaucoma Center ease are diagnosed and treated with Emergency Center for Excellence in cutting-edge therapies. Treatment op Care and Research The Eye Trauma and Emergency Cen tions for wet macular disease include ter, under the direction of Dr. Robert In the United States, glaucoma is the therapy and participation in clinical Alan Goldberg, provides immediate second cause of irreversible legal studies that are matched to the pa response to ophthalmic emergencies blindness. If glaucoma is detected ear tient’s disease status. A patient coor through an eye trauma team avail ly, however, vision loss can be slowed dinator is available to answer ques able 24 hours a day for consultative, or even prevented. Under the direc tions and provide information on an medical, and surgical care involving tion of Dr. Joseph Caprioli, the Glau ongoing basis. both primary and secondary ocular coma Center for Excellence in Care repairs. Ophthalmic emergency care and Research is committed to giving has been provided by the UCLA De each patient a chance for a brighter Ocular Inflammatory partment of Ophthalmology since its future and a life filled with sight. Disease Center inception. In 1980, the Eye Trauma Stein Eye Institute researchers, The Ocular Inflammatory Disease and Emergency Center was formally Drs. , , Center, under the direction of Dr. established to encompass all levels of Anne L. Coleman JoAnn A. Giaconi , , Gary N. Holland, was established in ocular trauma within the UCLA hospi Jacky M. K. Kwong Simon K. Law , and 1985 to coordinate research, educa tal system, including support to affili Kouros Nouri-Mahdavi Natik , are working with researchers and tional activities, and patient-care ser ated institutions. Piri statisticians from the UCLA School of vices related to a broad spectrum of Patients are commonly referred to Public Health to identify individuals at inflammatory eye disorders, including the Center for such ocular traumas greatest risk for vision loss, to devel uveitis, infectious corneal ulcers, en as ruptured globe, intraocular foreign op and assess therapeutic strategies, dophthalmitis, autoimmune diseases bodies, acute orbital hypertension, and to implement new treatments to of the cornea and ocular surface, and retinal detachment, chemical burns preserve vision. the ophthalmic manifestations of HIV of the cornea and conjunctiva, and disease. The Center has a long history acute vitreous hemorrhage. The Cen of participating in clinical studies and ter offers complete evaluation and Macular Disease Center drug-therapy trials that have furthered treatment of the traumatically injured the understanding and treatment of The Macular Disease Center, under the eye, including vitreoretinal and/or or these diseases. direction of Dr. Steven D. Schwartz, bital and ophthalmic plastic surgery, was created in 1994 in response to the Center faculty members were the anterior segment surgery, and medi growing national incidence of macular first to describe cytomegalovirus ret cal follow up. Expertise is provided for degeneration. The Center’s mission is initis as an ophthalmic manifestation both urgent primary repair and sched threefold: provide high-quality patient of AIDS; today the Center is a na uled secondary repair. care, utilizing standard and develop tionally recognized site of expertise ing treatments; offer associated reha for AIDS-related ophthalmic disease. Other special clinical and research Gerald Oppenheimer Family bilitation services, such as low-vision aids and counseling, in order to en programs have been developed in the Foundation Center for the following areas: ocular toxoplasmosis, Prevention of Eye Disease hance quality of life for patients; and promote collaborative translational re uveitis in children, birdshot chorioret Established with a generous pledge search between clinicians and basic inopathy, immunogenetics of inflam from Gail and Gerald H. Oppen- science researchers into the cause of matory eye diseases, unusual corneal heimer, the Gerald Oppenheimer macular disease. infections, and mediators of intraocu Family Foundation Center for the Pre lar inflammation. Patients with the atrophic or dry form vention of Eye Disease is committed of macular disease are evaluated and to the discovery of agents and meth often considered for clinical trials, such ods to prevent ophthalmic diseases. as the stem cell programs, and their Areas of study supported by the cases are followed at the Macular Foundation include genetic and envi Disease Center in conjunction with ronmental factors that may cause eye services offered by the Vision Re disease, and pharmacologic and natu habilitation Center. Patients with the ral agents to prevent eye disease. The Center complements an expanding array of research in many other fields at UCLA, where rigorous scientific methods are being applied to study novel approaches to health care.

Programs | Stein Eye Institute 99 Research and Treatment Centers

analysis of diagnostic data, together Ophthalmic Oncology Center with information from the patient’s UCLA Laser Refractive Center The Ophthalmic Oncology Center, medical history and comprehensive The UCLA Laser Refractive Center is under the direction of Dr. Tara A. physical examination, enables Center under the direction of Dr. David Rex McCannel, is renowned for its exper physicians to determine the nature of Hamilton. Founded in 1991, the Cen tise in teaching, research, and clinical the disease and devise a treatment ter specializes in refractive surgery of management of adult posterior seg plan. Treatment may be medical or both the cornea and lens of the eye, ment tumors. Established in the early surgical depending on the nature of including clinical and research appli 1980s by the Institute’s Founding Di the referral and the patient’s disease cations of new laser technology. The rector, Dr. Bradley R. Straatsma, the status. As part of the Center’s clinical Center is one of a few in the United Center is internationally recognized for research effort, physicians are refin States to pioneer investigations into the diagnosis and management of oc ing disease classifications along with laser eye surgery. ular melanoma. The Center serves as diagnostic and treatment approaches The UCLA Laser Refractive Center of a hub for national, long-term studies to further the field of optic neuropathy fers all cornea refractive procedures, investigating ocular melanoma, and and improve options for patients with including LASIK and LASEK/PRK, astig played an important role in the Collab these complex disorders. matic keratotomy, conductive kerato orative Ocular Melanoma Study spon plasty, and intracorneal ring implanta sored by the National Eye Institute. Orbital Disease Center tion. Advanced intraocular lens (IOL) The Center’s clinical goal is success procedures are also available, includ ful treatment of the primary eye tu The Orbital Disease Center, under ing presbyopia-correcting IOLs (multi mor. Patients diagnosed with ocular the direction of Drs. Daniel B. Root- focal and accommodating), toric IOLs, melanoma may be offered highly so man and Robert Alan Goldberg, and phakic IOLs. Patients referred to phisticated treatment plans coordinat was founded in 1991. The Center the Center undergo a complete ocu ed with UCLA radiation physicists and brings multidisciplinary expertise to lar examination that includes corneal radiation oncologists. Patients may the treatment and study of orbital topographic mapping, wavefront anal also qualify to participate in clinical diseases arising from trauma, cancer, ysis, and corneal biomechanical mea research studies in partnership with inflammation, and infection. Care is surements to identify conditions that the UCLA Jonsson Comprehensive organized around a team of experts in may interfere with surgical correction Cancer Center. The Center’s primary ophthalmology, interventional neuro of refractive errors. Candidates for la research goal is to gain a fundamental radiology, neurosurgery, head and neck ser or intraocular lens surgery receive understanding of the molecular biolo surgery, radiation oncology, and cra intensive education to understand the gy of metastatic ocular melanoma. In niofacial surgery, bringing to the treat benefits, risks, and alternatives to sur addition to providing genetic prognos ment of orbital diseases a depth of gery. Participation in clinical trials for tic information to patients on their risk knowledge and experience not avail new refractive devices and techniques of tumor metastasis, the Center has able elsewhere in Southern California. to treat nearsightedness, farsighted identified key genes associated with The Center provides both medical ness, and presbyopia may be an op metastatic tumors. and surgical management of orbital tion for qualified patients. For more diseases. The team performs proce information about the UCLA Laser Re dures that are not usually available in fractive Center, go to: www.uclaser. Optic Neuropathy Center the community, including orbital de com and lasik.ucla.edu. Under the direction of Dr. Anthony compression, microsurgery for orbital C. Arnold, the Optic Neuropathy Cen apical tumors, optic canal decompres ter provides multidisciplinary consul sion, combined interventional neu tation, diagnosis, and treatment for roradiology procedures for vascular patients with complex diseases in tumors, and bony reconstruction to ad volving the optic nerve. Established dress traumatic or congenital defects. in 1991, the Center incorporates spe The Center has an active program in cialized facilities and equipment for thyroid eye disease, where new sur diagnostic testing and offers consul gical techniques are evaluated, and tation from neuro-ophthalmologists, basic science research is carried out orbital surgeons, neurologists, neuro to advance understanding about the radiologists, and neurosurgeons. disease. A fellowship program trains future leaders, and teaching courses Patients referred to the Optic Neurop draw international audiences of highly athy Center receive advanced diag trained orbital specialists to learn the nostic testing of the orbit and optic latest advances in the field. nerve to assist in evaluation. Extensive

100 Stein Eye Institute | Programs Research and Treatment Centers

Vision Genetics Center Vision Proteomics Center Vision Rehabilitation Center

Initially established in 1978 as the Genes encode the sequences of pro The Vision Rehabilitation Center, un UCLA Retinitis Pigmentosa Registry, teins, and knowledge of the struc der the direction of Dr. Melissa W. the Vision Genetics Center, under the ture and function of these proteins Chun with Dr. Steven D. Schwartz direction of Dr. Michael B. Gorin, is is required to unlock the secrets of as medical advisor, was established an integrated clinical and research the cell. That task is now set before to provide rehabilitation to maximize program that addresses the full spec current and future generations of visual function and quality of life of pa trum of hereditary eye disorders. Cen scientists, and a new field of study, tients with low vision, defined as best ter members, representing multiple Proteomics, has been born. It is only corrected vision of 20/70 or worse disciplines, combine their efforts to through an understanding of protein in the better eye. These outcomes understand the underlying molecular function at the molecular level that are accomplished with a rehabilitation basis of a broad range of ocular con researchers can learn the fundamen plan tailored to each patient’s specific ditions, including those involving the tal origins of disease and develop ra needs and goals. development of the eye, cornea, lens, tional therapeutic designs to correct The Center provides assistance in the extraocular muscles, retina, vitreous, defects in the molecular machinery. form of patient consultation and train and optic nerve. Areas of interest The Vision Proteomics Center at the ing, including reading and computer include both simple inherited condi Stein Eye Institute, under the direc training, as well as evaluation with tions caused by alterations in single tion of , with re the latest low-vision devices that can genes, as well as conditions in which Dr. Wayne L. Hubbell searchers , help patients adapt to their visual re multiple genetic variations and other Drs. Ben J. Glasgow Dean , , and strictions. The Center utilizes a wide risk factors play a role. Bok Joseph Horwitz Gabriel H. Travis, has pioneered the develop array of technologically advanced de The Center offers patients and their ment of site-directed spin labeling–– vices, such as magnifiers, telescopes, family members state-of-the-art di the only one of its kind in the world, and digital and computer technology. agnosis and care of the hereditary ushering in a new era of exploration Customized for each patient’s individ eye or vision condition. Services in of structure/function relationships in ual needs, services may range from clude genetic counseling, and when proteins. Research groups at the Stein simple solutions to specialized ap appropriate, DNA testing either as a Eye Institute, departments at UCLA, proaches. One unique feature of the clinical diagnostic service, a research and other major institutions through Center is a special “lending library” of program, or in combination. The Cen out the United States and abroad, select low-vision devices that enables ter’s faculty members collaborate are taking advantage of the singular patients to try devices at home or in with a number of genetic research opportunities provided by the Vision the office prior to purchase. When groups around the world to ensure Proteomics Center. appropriate, referrals are provided that patients can participate in the to assist independent living through most advanced research for their par occupational therapy and orientation ticular condition. and mobility training. During the past year, the Center has initiated involvement in a natu ral history study and clinical trial for gene therapy for choroideremia and a therapeutic clinical trial for Star- gardt Disease.

Low-vision devices, available from the Vision Rehabilitation Center, help patients adapt to their visual restrictions.

Programs | Stein Eye Institute 101 Patient Care Services Clinical Laboratories

he Ophthalmology Clinical Lab to noninvasively measure LASIK re Laboratory is conducting clinical stud Toratories provide precise mea sidual bed thicknesses and flap thick ies to evaluate the effectiveness of surements, photographs, and quan nesses as well as evaluate the LASIK each photographic modality in terms titative studies of the eye and the interface for possible infections, dif of predictive accuracy and early de visual system. Quantitative informa fuse lamellar keratitis, and ingrowth. tection of glaucoma. tion of this type enhances patient care by increasing the accuracy of Glaucoma Photography Live Imaging and diagnosis and enlarging the parame Laboratory Functional Evaluation (LIFE) ters employed to assess the clinical Core Laboratory course and effectiveness of treat The Glaucoma Photography Laborato ment. Additionally, the clinical labo ry, under the direction of Dr. Joseph The Live Imaging and Functional Eval , provides specialized photo uation (LIFE) Core Laboratory is jointly ratories expand the scope of treat Caprioli graphs for new and follow-up patients supervised by Drs. Steven Nusino ment alternatives, promote clinical to assist the ophthalmologist in the witz and Alapakkam Sampath. The research, and generally augment management of patients with glau LIFE Module directors are commit the effectiveness of ophthalmic dis coma. The GDX Nerve Fiber Analyzer ted to the provision of state-of-the- ease management. The laboratories utilizes polarized light in place of dila art noninvasive in vivo imaging and are available to all ophthalmologists tion to measure the thickness of the functional analysis of animal models in the community. nerve fiber layer. This test is partic of ocular disease and treatments. ularly useful in diagnosing new glau Testing provided by the module in Find out more about UCLA coma. Heidelberg retinal tomography, cludes full-field and multi-focal elec Department of Ophthalmology using confocal laser light, measures ad troretinography (ERG), pattern electro- research by going to: www. ditional parameters of the optic nerve retinography (pERG), and flash and uclahealth.org/eye/research- and provides more information on the pattern visually-evoked cortical poten nerve fiber layer. Optical coherence tials (fVECP and pVECP, respectively). laboratories. tomography utilizes reflected light to For all of these tests, the ERG com measure the nerve fiber layer as well ponent of interest is extracted from as to measure macular holes as a the waveform targeting a specific cell Corneal staging procedure for surgical repair. type of interest. Structural analysis is Diagnostic Laboratory An ophthalmic fundus camera photo provided by direct fundus imaging, graphs the optic nerve in stereo. The auto-fluorescence imaging, angiogra The Corneal Diagnostic Laboratory, phy, and optical coherence tomogra under the direction of Dr. Anthony J. phy (OCT). Aldave, offers a comprehensive array of corneal imaging modalities. Ser vices include imaging of the anterior and posterior corneal surfaces with the Marco OPD-Scan III and Optovue RTVue, and imaging of the corneal en dothelium for assessment of corneal endothelial cell morphology and den sity using the KONAN CellChek XL specular microscope. Full-thickness confocal microscopic imaging of the cornea, a useful tool in the diagnosis of suspected fungal, acanthamoebic, and other parasitic infections of the cornea, is performed with the Heidel berg HRT3 confocal microscope. This instrument and the Optovue RTVue can also perform optical pachymetry

102 Stein Eye Institute | Programs Clinical Laboratories

the eye. The Laboratory also supports eye diseases such as glaucoma, ret Ocular Motility Clinical and the research and teaching activities of inal disorders, and neuro-ophthalmic Basic Science Laboratory the Stein Eye Institute by preparing conditions. Utilizing pinpoints of light The Ocular Motility Clinical and Basic and duplicating graphic materials for around a perimetry bowl, the test eval Science Laboratory, under the direc presentation and publication. uates different areas of the field of tion of Dr. Joseph L. Demer, records vision. Test results are computerized and quantitatively analyzes eye move and compared to a range of normal ment abnormalities resulting from oc Ophthalmic Ultrasonography values by age group. Patterns of di ular and neurological disorders, such Clinical Laboratory minished fields of vision are related to specific eye diseases. Perimetry test as ocular myasthenia gravis. Several The Ophthalmic Ultrasonography Clini ing is employed for diagnostic pur types of tests are performed. The cal Laboratory, directed by Dr. Steven poses and to monitor visual field sensi Hess test utilizes specialized eye D. Schwartz, performs clinical exam tivity over time, especially for glaucoma charts and lenses to assist in the di inations that are useful in diagnosing patients. Both standard and shortwave agnosis of a number of problems, in both ocular and orbital eye diseases. automated techniques are available, in cluding double vision. Magnetic scler Diagnostic examinations include stan addition to frequency-doubling perim al search coil techniques are utilized dardized A-scan, B-scan, and ultra etry and motion-detection perimetry. in clinical research studies to detect sound biomicroscopy. Standardized fine movements not evident through A-scan is useful in tissue differenti normal visual examination. Another ation and is commonly employed to test involves the visual recording of Visual Physiology diagnose ocular and orbital tumors, Clinical Laboratory eye movement using a video cam- including choroidal melanoma. B-scan era. The Laboratory also engages in provides location and contour infor The Visual Physiology Clinical Lab basic science research to further un mation and is particularly useful in dif oratory, under the direction of Drs. derstanding of eye movement, as well ferentiating vitreous membranes from Michael B. Gorin and Steven Nusi as diseases of the eye, brain, and retinal detachment. Ultrasound biomi nowitz, quantitatively evaluates the muscles, and related tissues of the croscopy provides exquisitely detailed, function of the retina and visual path- inner ear. high-resolution views of the anterior ways. Patients are referred for func segment of the eye and is a critical tional testing to confirm a specific tool for the evaluation of ocular pathol diagnosis, or in cases where the eti Ophthalmic Photography ogy, especially in opaque corneas. ology is unknown, to rule out alter Clinical Laboratory native diagnostic possibilities. Elec Biometry and intraocular lens calcula trophysiological tests, including both The Ophthalmic Photography Clini tions are also performed in the Lab the full-field and multifocal electro cal Laboratory, under the direction of oratory. Biometry measures the axial retinograms (ERG and mfERG), the Dr. Tara A. McCannel, provides a eye length, anterior chamber depth, electro-oculogram (EOG), and visually wide array of photographic techniques and lens thickness; intraocular lens cal evoked cortical potentials (VECP), re important in patient care, research, culations are performed to determine cord electrical signals from different and teaching. The primary purpose the power of the lens implant for cat layers of the visual system to identify of ophthalmic photography in patient aract patients. care is to record the present state of the site responsible for visual symp the eye, and in cases of abnormality, toms. Psychophysical tests require to establish a baseline and monitor the Perimetry Laboratory the participation of the patient in spe patient’s condition over time. Patient cific tasks to evaluate visual functions care services include photographic The Perimetry Laboratory, under the like color blindness, contrast sensitiv documentation of anterior segment direction of Dr. Joseph Caprioli, per ity, and visual acuity. In many cases, diseases involving corneal problems forms visual field examinations that both electrophysical and psychophys like growths, infection, and trauma; determine the sensitivity of central ical tests are performed together to photographs of ocular motility to re and peripheral vision. Examinations obtain the optimum amount of infor cord abnormalities in eye movement; are conducted with advanced Hum mation for diagnosis. fundus photography, which captures phrey automated perimetry equip pictures of the retina; and diagnostic ment. Testing detects visual field defi testing using fluorescein and indo cits associated with certain kinds of cyanine green angiography, which re cords the dynamics of blood flow in

Programs | Stein Eye Institute 103 Patient Care Services Training Programs

he Stein Eye Institute and the UCLA UCLA Medical Student TUCLA Department of Ophthal Medical Student Program Research Program mology jointly provide comprehen sive training in ophthalmology and Each academic year, the UCLA De At the Stein Eye Institute, medical vision science to medical students, partment of Ophthalmology and the students have taken short-term labo residents, and clinical and research Institute extend instruction to UCLA ratory and clinical research electives fellows. The programs encompass medical students in their second, for decades. In addition, there is now the gamut of ophthalmic and vision third, and fourth years of instruc a Medical Student Research Program tion. Through lectures, small group that provides select medical students science education, representing ev discussions, and clinical experience, with a year-long opportunity to partic ery level of training and incorporat all students have numerous training ipate in laboratory or clinical research ing a full range of subjects in the sessions from which to gain knowl in the field of ophthalmology. Each study of the eye. The residency pro edge about eye diseases and develop year, a committee selects one or two gram is rated one of the top in the eye examination skills that should be medical student researchers to re country. A large patient population known by all physicians, regardless of ceive salary and research support for with diverse vision problems offers their specialties. Those students who 12 months in the laboratory or clinical innumerable training opportunities are interested in ophthalmology as a research area of the student’s chosen for both residents and clinical fel career have additional learning oppor mentor. The goal of the program is to lows. The availability of more than tunities in elective courses. encourage medical students to pursue careers in academic ophthalmology. 15 research laboratories ensures a In their second year of instruction, all wide choice of vision science proj medical students attend a series of ects for all trainees. Predoctoral lectures distributed throughout their UCLA Ophthalmology and postdoctoral research fellows year-long Human Biology and Dis Residency Program particularly benefit from the wealth ease course, covering various topics of new and unfolding research related to eye diseases. Students also The Department of Ophthalmology generated by vision scientists at attend several afternoon workshops conducts an accredited three-year res the Institute. during which they learn eye examina idency program for 24 residents; eight tion skills and treatments for eye prob new residents begin training each July. lems that can be managed by non- The full breadth of ophthalmology train Learn more about UCLA ophthalmologists. During their third ing is offered, including experience in Department of Ophthalmology year of instruction, medical students general ophthalmology and ophthalmic Training Programs at: interested in additional training and subspecialties. Training incorporates www.uclahealth.org/eye/ experience can elect to spend two the resources of the UCLA Stein Eye ophthalmology-fellowship- weeks of their surgical clerkship on Institute, Harbor-UCLA Medical Cen training- programs. the Ophthalmology Service, examin ter, Olive View-UCLA Medical Cen ing patients in clinic and observing eye ter, and the Veterans Affairs Greater surgeries. During the fourth year of in Los Angeles Healthcare System at struction, a series of advanced clinical West Los Angeles and Sepulveda. electives are available to medical stu Every resident has exposure to each dents who plan eventually to practice medical center during the course of ophthalmology as their specialty. training, thereby ensuring clinical ex perience with a wide range of prob lems and patient populations. Cer tification by the American Board of Ophthalmology is a natural objective of the program.

104 Stein Eye Institute | Programs Training Programs

Clinical Rotations Research EyeSTAR Program Clinical rotations at the Stein Eye In An understanding of and an appreci stitute include both general ophthal ation for research are major prerequi For physicians who are interested in mology and subspecialties. In gener sites for assimilating future develop academic careers and professional al, ophthalmology residents work as a ments in ophthalmology. Accordingly, leadership as clinician-scientists, the team, handling clinics, emergencies, ophthalmic research is an integral com Stein Eye Institute offers an Ophthal and walk-in patients. They also serve ponent of residency training. Resi mology Specialty Training and Ad as an ophthalmology consult service dents are expected to undertake inde vanced Research Program, referred for inpatients in the UCLA Medical pendent investigation or to participate to as EyeSTAR, which offers vision Center. Residents assigned to subspe in ongoing clinical or basic science science training combined with an cialty service rotations are provided research projects in ophthalmology. ophthalmology residency. Appointees with intensive exposure to the various Residents present the results of their complete a residency program leading divisions within the Department, work work at the Stein Eye Institute Clini to certification in ophthalmology, as ing closely with faculty members in a cal and Research Seminar during their well as laboratory research experience private practice environment. At the second and third years of residency. leading to a doctorate, or postdoctoral UCLA-affiliated medical centers, resi They are also encouraged to report training in the event that the trainee dents work in teams that provide both their studies at regional and nation already has a doctorate. EyeSTAR general and subspecialty patient care. al meetings and publish their results trainees work under the guidance of a in scientific journals. Residents with faculty advisory panel representing the Didactic Education special clinical or research interests trainee’s clinical and research interests. Residents receive didactic education have an opportunity to use elective The unique program began in 1995 in the classroom on an ongoing basis. time to increase their exposure to and is geared to physicians commit Once each week, all residents attend a particular area of ophthalmology. ted to academic careers in ophthal a mandatory half-day program that in This time can be spent with full-time mology, combining basic science with cludes faculty lectures that, over the or volunteer faculty at UCLA or at clinical practice in a five-year or six- course of the three-year program, cov other institutions. year curriculum. EyeSTAR graduates er each of the required subjects in the are trained to compete not just with American Academy of Ophthalmolo clinical scientists but also with top EyeMBA: Innovation in gy Basic and Clinical Sciences Course. basic scientists from all institutions. Medical Education These lectures are followed by Grand Trainees select their faculty mentors Rounds, which consist of presenta The Institute recently created another from the Vision Research Division of tion and discussion of specific patient national first for medical education by the Stein Eye Institute or from the cases, and faculty lectures on clinical working with the David Geffen School David Geffen School of Medicine at topics related to ophthalmic subspe of Medicine at UCLA and the UCLA UCLA, College of Letters and Sci cialties. Throughout the week, clinical Anderson School of Management to ences, School of Public Health, Clinical conferences in ophthalmic subspe develop EyeMBA, a master’s of busi Scholars Program, and RAND Grad- cialties are held where problems are ness administration degree that is uate School. presented and discussed. earned in tandem with an ophthalmol EyeSTAR is recognized by the Nation ogy residency—the only joint program al Eye Institute and the Association of Surgery Training of its kind. University Professors of Ophthalmol Residents begin to perform surgery in EyeMBA was developed in recogni ogy as a model training program for their first year of training and continue tion that future leaders in ophthalmol clinician-scientists in ophthalmology. to operate throughout their residen ogy will need the financial, manage cy. Surgical cases are assigned com ment, and measurement skills that mensurate with level of training and are at the core of an MBA curriculum. experience. First-year residents begin Residents in the EyeMBA program in the Institute’s Microsurgery Labo gain skills that are broadly applicable ratory, an organized surgical course to ophthalmologic leadership in aca that includes computerized surgical demia, translational research, health simulators. This facility is available system management, health care de to residents throughout their train livery, and the biomedical industry. ing. Residents first assist on select ed surgical cases, and by the end of their residency, they are performing procedures independently.

Programs | Stein Eye Institute 105 Training Programs

cases at the Stein Eye Institute. Fel management of a broad array of ret UCLA Clinical Ophthalmology lows work in the microsurgical labora inal disorders, including age-related and Vision Science tory and assist in teaching microsurgi macular degeneration, diabetic reti Fellowship Programs cal skills to ophthalmology residents. nopathy, retinal vascular disease, in The Stein Eye Institute offers particu Under the direction of faculty, fellows flammatory retinopathies, drug-relat larly well-qualified persons the oppor also perform primary surgical proce ed toxic retinopathies, and retinal and tunity to receive fellowship training in dures in the UCLA Laser Refractive macular degenerations and dystro specific areas of clinical ophthalmolo Center. In addition to in-depth train- phies. Fellows are instructed in the gy or vision-science research. ing at the Institute, fellows provide proper use and interpretation of non medical and surgical care to patients invasive diagnostic tools, and training Following successful completion of a at the Veterans Affairs Greater Los includes genetic counseling and the residency program, a clinical fellow Angeles Healthcare System at West proper use of molecular genetic diag ship combines outpatient, inpatient, Los Angeles and at Harbor-UCLA nostics. Fellows gain experience with and surgical experience in an ophthal Medical Center. Fellows typically com- a diverse set of interventional skills, mic subspecialty. The clinical fellow plete an original clinical or laboratory including a wide spectrum of retinal assumes increasing responsibility for research project, and frequently co- laser procedures and periocular and patient care under the supervision of author a book chapter or review dur- intravitreal injection of various classes faculty members responsible for the ing their training. of drugs. program. In addition to receiving train ing from faculty, the fellow instructs Fellowship in Glaucoma Fellows divide their time among the medical students and residents. Re clinical practices of Drs. Gorin, David Under the direction of Drs. Joseph search is considered an important Sarraf, and Colin A. McCannel with Caprioli, Anne L. Coleman, JoAnn aspect of specialty training and a main the Division of Retinal Disorders A. Giaconi, Simon K. Law, and jor prerequisite for assimilating fu and Ophthalmic Genetics, the Retina Kouros Nouri-Mahdavi, the one- ture developments in ophthalmology. Division of the Doheny Eye Institute, year or two-year glaucoma fellow Clinical fellows are expected to un as well as in the Retinal Diagnostics ship provides clinical and laboratory dertake independent investigation or Unit and the Visual Physiology Lab experience in glaucoma diagnosis and to participate in one of the ongoing oratory directed by Dr. Steven Nu management. Fellows gain clinical ex research projects in a field related to sinowitz at UCLA. Dr. McCannel’s perience by examining patients in the their specialty. clinic provides exposure to surgical consultation suite and participating retinal decision-making and manage Vision-science fellowship training is in the clinical and surgical manage ment issues. The fellows also provide laboratory based and offers both pre ment of patients. Fellows work in the care and teach residents in retina sub doctoral and postdoctoral opportuni Glaucoma Microsurgery Laboratory, specialty clinics at two UCLA-affiliated ties to trainees in specific areas of vi participate in microsurgery courses, hospitals. Fellows are strongly encour sion science that encompass a wide assist in the Glaucoma Clinic, and aged to engage in translational clini range of topics. Trainees work under develop expertise in the various di cal research and/or clinical trials and the supervision of Institute faculty agnostic techniques used in glauco descriptive retrospective studies and members who are engaged in basic ma treatment through preceptor-type develop an in-depth working knowl science research and have active lab relationships with faculty. Fellows par- edge of the current scientific liter oratories. The scope and nature of the ticipate in glaucoma teaching at the ature of medical and genetic retina. training program for each predoctoral Stein Eye Institute and affiliated in They are expected to participate in or postdoctoral fellow is developed by stitutions, present cases at teaching genetic and imaging conferences as the trainee and his/her faculty mentor. rounds, and prepare presentations for well as other relevant meetings. regularly scheduled glaucoma confer Fellowship in Cornea– ences. Fellows also undertake at least Fellowship in External Ocular Diseases and one research project, which may be Neuro-Ophthalmology Refractive Surgery a clinical study or an applied research The one-year fellowship in neuro- project in the laboratory, in coopera Under the direction of Drs. Anthony ophthalmology, under the direction tion with the faculty advisor. J. Aldave, Sophie X. Deng, David of Dr. Peter A. Quiros, involves a close Rex Hamilton, and Kevin M. Miller, preceptor-preceptee relationship, par Fellowship in Medical Retina one-year fellowships are offered in ticipation in teaching rounds, and work the study of diseases of the cornea, This combined Stein Eye Institute and in the private consultation suite. The external eye, anterior segment, and Doheny Eye Institute one-year fel David Geffen School of Medicine at refractive surgery. Clinical experience lowship, under the co-directorship of UCLA maintains major clinical and re consists of participation in the cornea Drs. Michael B. Gorin and SriniVas search programs in neurology, neuro faculty practices, including surgery, R. Sadda, provides clinical knowl surgery, and neuroradiology. Fellows and in the care of emergency cornea edge pertaining to the diagnosis and attend the weekly Neurology and

106 Stein Eye Institute | Programs Training Programs

Neurosurgery Grand Rounds, take including fine-needle aspiration; elec peer-reviewed scientific journals, fel an active part in seeing relevant in tron microscopy; immunohistochem lows complete a formal thesis that patient consultations throughout the istry; DNA in situ hybridization; South partially satisfies the membership re Medical Center, and assist in select ern blot analysis; and polymerase quirements of the American Society of ed surgical procedures of interest to chain reaction techniques for diagnos Ophthalmic Plastic and Reconstructive neuro-ophthalmologists. Attendance tic work. The fellowship programs are Surgery. International research fellows at the weekly neuroradiology teach individualized according to the creden also participate in the program annu ing conferences is encouraged. Time tials and capabilities of each fellow. ally. The two-year fellowship program is allotted for scientific reading and is approved by the American Society for research activities. Participation in Fellowship in Orbital and of Ophthalmic Plastic and Reconstruc clinical research, such as studies of Ophthalmic Plastic Surgery tive Surgery. eye movement disorders and distur Fellowships in orbital and ophthal bances of visual pathways, is expected. mic plastic surgery, under the over Fellowship in Pediatric Ophthalmology and Strabismus all supervision of Drs. Robert Alan Fellowship in Goldberg and Jonathan Hoenig, pro- The division of Pediatric Ophthalmol Ophthalmic Pathology vide training for ophthalmologists who ogy and Strabismus offers one-year Under the direction of Dr. Ben J. are interested in specializing in orbit fellowships, under the directorship Glasgow, this fellowship provides al and adnexal disorders, and in aes of Drs. Sherwin J. Isenberg and preparation for an academic career thetic and reconstructive orbitofacial Joseph L. Demer. Clinical experience in ophthalmic pathology. One-year, surgery. Fellows participate in orbital consists of supervised participation two-year, and three-year training pro and ophthalmic plastic surgery out in the ophthalmic care of pediatric grams are available depending on the patient consultation, inpatient care, patients seen at the Stein Eye Insti background of the applicant. Train and surgical procedures at the Stein tute, Harbor-UCLA Medical Center, ing encompasses many aspects of Eye Institute and affiliated hospitals. and Olive View-UCLA Medical Cen ophthalmic pathology. Fellows may They also participate extensively in ter. Specific activities include partic- choose between a research-based the teaching and research activities ipation in University Ophthalmology or clinical -based curriculum. Clinical of the Orbital and Ophthalmic Plastic Associates, the Nursery and Neona fellows gain expertise in surgical pa Surgery Division. In addition to pub tal Intensive Care Units, Ophthalmic thology; autopsy pathology; cytology, lishing results of original research in Plastic and Reconstructive Surgery Service, and the Pediatric Retinal Ser vice. Other activities in pediatric oph thalmology include experience in the private consultation suites and partic ipation in pediatric cases that are han dled through other services. Fellows may collaborate with vision scientists, including biochemists, physiologists, pathologists, and anatomists, on re search projects of mutual interest.

Fellowship in Vision Science Predoctoral and postdoctoral fellow ships in vision science are offered to individuals who have an interest in specific research areas being pursued by Institute faculty in highly special ized laboratory environments. These fellowships are supported either by individual funds available to Institute professors or as part of a special pro gram offered under the auspices of a National Eye Institute Vision Science Training Grant directed by Dr. Gabriel H. Travis.

Programs | Stein Eye Institute 107 Training Programs

Predoctoral fellows take a defined Fellowship in encouraged. Other activities include program of core courses and carry Vitreoretinal Diseases teaching of vitreoretinal diseases at out eye-related research, obtaining and Surgery the Stein Eye Institute and affiliated doctorates in about six years. Fellows Under the co-directorship of Drs. Allan institutions and case presentations at are required to present their research E. Kreiger and Steven D. Schwartz, teaching sessions. The program also at informal and formal seminars, and the Vitreoretinal Diseases and Surgery includes the participation of several are encouraged to participate in na Fellowship in the Department of Oph international fellows. tional and international meetings and thalmology at the Stein Eye Institute is publish scientific papers. They gain a two-year program designed to pro International Fellowship and a broad background in the vision sci vide medical and surgical training and Exchange Program ences by interacting with members clinical- and vision-science research of adjacent laboratories and collab opportunities related to vitreoretinal To promote and encourage research orating with faculty members other disease. Major components of the and education interaction with oph than their own preceptors. Postdoc fellowship relate to diabetic retinop thalmology institutions throughout the toral research fellowships are offered athy, diseases of the macula and ret world, the Stein Eye Institute offers for one to three years. Each one is ina, hereditary retinal degenerations, an International Ophthalmology Fel unique with research programs estab ocular trauma, ophthalmic oncology, lowship and Exchange Program con lished according to mutual agreement rhegmatogenous retinal disease, vit sisting of one-year to two-year fellow- between trainees and mentors. Re reoretinal surgery, pediatric retinal dis- ships under the supervision of specific search areas for postdoctoral fellows ease, and diagnostic imaging. Clini Institute faculty. Candidates for these include molecular biology, genetics, cal training includes the prevention, fellowships are nominated by presti biophysics, biomechanics, cell biolo diagnosis, and treatment of retinal, gious institutions outside the United gy, eye development, and biochemis choroidal, vitreous, and related ocular States and often hold academic po try. Upon completion of their fellow disease. Fellows participate in retinal sitions within their own countries. ships, trainees usually pursue careers clinics and surgical procedures at the Fellows participate in the clinical and in academia or industry. Stein Eye Institute and four UCLA- research activities of ophthalmic sub affiliated hospitals. Clinical, laborato specialties according to their train- ry, or translational research is also ing needs.

108 Stein Eye Institute | Programs Appendices Appendices UCLA Department of Ophthalmology Volunteer and Consulting Faculty

olunteer and consulting fac Associate Clinical Professors Assistant Clinical Professors Vulty––many of whom have con of Ophthalmology of Ophthalmology tributed to the Department’s edu Gerrald Barron, MD (Senior Status) David H. Aizuss, MD cational mission for more than 25 Arnold Barton, MD (Senior Status) Malvin B. Anders, MD Kevin J. Belville, MD Richard K. Apt, MD years––teach courses, participate Louis Bernstein, MD (Senior Status) Reginald G. Ariyasu, MD, PhD in conferences, and bring hands-on W. Benton Boone, MD Arthur A. Astorino, MD practical experience and common Harvey Brown, MD Mark A. Baskin, MD sense guidance that is invaluable to Andrew E. Choy, MD Arthur Benjamin, MD young ophthalmologists in training. Melissa W. Chun, OD Katherine L. Bergwerk, MD Peter J. Cornell, MD Betsy E. Blechman, MD Bernard Davidorf, MD (Senior Status) Cynthia A. Boxrud, MD Paul B. Donzis, MD Amarpreet S. Brar, MD Kathryn M. Gardner, MD Almira W. Cann, MD, PhD Volunteer Faculty Donald I. Goldstein, MD Arnett Carraby, MD Michael J. Groth, MD Vicki K. Chan, MD Andrew Henrick, MD Andrew M. Chang, MD Clinical Professors Edwin P. Hill, MD Candice Chen, MD of Ophthalmology Jonathan A. Hoenig, MD Thomas B-H. Choi, MD J. Bronwyn Bateman, MD Richard H. Hoft, MD Milton W. Chu, MD Bruce B. Becker, MD, PC David F. Kamin, MD Robert A. Clark, MD Michael S. Berlin, MD Stanley Kopelow, MD (Senior Status) Charles A. Cooper, MD William P. Chen, MD Joseph Lambert, MD (Senior Status) Yadavinder P. Dang, MD Paul Deiter, MD (Senior Status) Brian L. Lee, MD Jonathan M. Davidorf, MD Uday Devgan, MD, FACS, FRCS Steven Leibowitz, MD John L. Davidson, MD Chief of Ophthalmology Gene Matzkin, MD (Senior Status) Sanford S. Davidson, MD Olive View-UCLA Medical Center Joan E. McFarland, MD Louise Cooley Davis, MD Donald Dickerson, MD (Senior Status) James McKinzie, MD (Senior Status) Farid Eghbali, OD Donald S. Fong, MD, MPH Alan Norton, MD (Senior Status) Troy R. Elander, MD Leland M. Garrison, MD John F. Paschal, MD (Senior Status) Naomi L. Ellenhorn, MD Thomas A. Hanscom, MD Firas Rahhal, MD Calvin T. Eng, MD John D. Hofbauer, MD George M. Rajacich, MD Robert E. Engstrom, MD Kenneth J. Hoffer, MD Michael Reynard, MD Doreen T. Fazio, MD C. Richard Hulquist, MD David S. Robbin, MD Sanford G. Feldman, MD Barry M. Kerman, MD David E. Savar, MD Laura E. Fox, MD Roger A. Kohn, MD Timothy V. Scott, MD Ronald P. Gallemore, MD Howard R. Krauss, MD Kayur Shah, MD George H. Garcia, MD Benjamin C. Kwan, MD Albert Sheffer, MD Leslie C. Garland, MD (Senior Status) Jeremy Levenson, MD (Senior Status) James D. Shuler, MD W. James Gealy, Jr., MD Jonathan I. Macy, MD Yossi Sidikaro, MD, PhD Damien Goldberg, MD Ezra Maguen, MD Matthew Sloan, MD Lawrence “Tim” Goodwin, MD Robert K. Maloney, MD Ronald J. Smith, MD Lawrence H. Green, MD (Senior Status) Samuel Maskeat, MD Alfred Solish, MD, MS Richard Havunjian, MD Leon G. Partamian, MD Kenneth D. Steinsapir, MD Man M. Singh Hayreh, MD George Primbs, MD (Senior Status) Sadiqa Stelzner, MD, MA, FACS Matthew L. Hecht, MD Yaron S. Rabinowitz, MD William C. Stivelman, MD (Senior Status) David A. Hollander, MD Teresa O. Rosales, MD Hector L. Sulit, MD Jeffrey Hong, MD Robert J. Schechter, MD (Senior Status) Kamal A. Zakka, MD Catherine J. Hwang, MD, MPH Stephen Seiff, MD (Senior Status) Morton P. Israel, MD Alan L. Shabo, MD Steven J. Jacobson, MD Norman Shorr, MD Batool Jafri, MD Roger W. Sorenson, MD (Senior Status) Aarchan Joshi, MD Véronique H. Jotterand, MD J. David Karlin, MD David S. Katzin, MD

110 Stein Eye Institute | Appendices Volunteer and Consulting Faculty

Assistant Clinical Professors Clinical Instructors of Ophthalmology continued in Ophthalmology Consulting Members James F. Kleckner, MD (Senior Status) Eduardo Besser, MD Jerome R. Klein, MD Maria Braun, MD of the Stein Eye Craig H. Kliger, MD Stephen S. Bylsma, MD Institute Howard E. Lazerson, MD (Senior Status) Andrew Caster, MD Robert T. Lin, MD Hajir Dadgostar, MD Robert W. Baloh, MD Joanne E. Low, MD John J. Darin, MD (Senior Status) Professor of Neurology and Surgery Bryant J. Lum, MD Paul J. Dougherty, MD (Head and Neck) Michael C. Lynch, MD Sean Dumars, MD Ferdinand V. Coroniti, PhD M. Polly McKinstry, MD Daniel Ebroon, MD Professor, Department of Physics Ashish M. Mehta, MD Brad S. Elkins, MD and Astronomy Kenneth J. Miller, MD (Senior Status) Satvinder Gujral, MD David Eisenberg, DPhil David R. Milstein, MD Lawrence M. Hopp, MD, MS Investigator, Howard Hughes Medical Institute Ronald L. Morton, MD Anisha J. Judge, MD Paul D. Boyer Professor of Biochemistry Roger L. Novack, MD, PhD Jason Jun, MD and Molecular Biology David Paikal, MD Rajesh Khanna, MD Professor, Departments of Chemistry Alpa A.S. Patel, MD Julie A. King, MD and Biochemistry, and Biological Chemistry Molecular Biology Institute James H. Peace, MD Monica R. Khitri, MD Gilbert Perlman, MD (Senior Status) Mark H. Kramar, MD Alan M. Fogelman, MD Cheryl J. Powell, MD Daniel Krivoy, MD Castera Professor and Executive Chair John R. Privett, MD (Senior Status) Laurie C. McCall, MD Department of Medicine Laurence N. Roer, MD Mitra Nejad, MD Alan D. Grinnell, PhD Gerald Sanders, MD (Senior Status) Jayantkumar Patel, MD Professor of Physiology and Aaron M. Savar, MD Susan S. Ransome, MD Physiological Science Director, Jerry Lewis Neuromuscular Barry S. Seibel, MD Steven H. Rauchman, MD Research Center Meryl Shapiro-Tuchin, MD Richard H. Roe, MD Director, Ahmanson Laboratory David M. Shultz, MD Louis M. Savar, MD of Neurobiology Eliot B. Siegel, MD Abraham Soroudi, MD C. Kumar Patel, PhD Lance M. Siegel, MD Sharon N. Spooner-Dailey, MD Professor, Department of Physics John D. Slaney, MD Laura A. Syniuta, MD and Astronomy Robert J. Smyth, MD Rosalind Vo, MD Kenneth O. Sparks, MD Mark Volpicelli, MD Leonard H. Rome, PhD Senior Associate Dean for Research Mehryar “Ray” Taban, MD, FACS Mathew Wang, MD Professor of Biological Chemistry Homayoun Tabandeh, MD Peter H. Win, MD Robert C. Tarter, MD Andrew Young, MD Peter C. Whybrow, MD Judson Braun Professor and Executive Chair Debra G. Tennen, MD Department of Psychiatry and Teddy Y. Tong, MD Biobehavioral Sciences Sterling M. Trenberth, MD (Senior Status) Director and Physician in Chief Robert C. Tudor, MD (Senior Status) Neuropsychiatric Institute Henry E. Ullman, MD Tay J. Weinman, MD (Senior Status) Irwin S. Weiss, MD (Senior Status) Sidney J. Weiss, MD Scott Whitcup, MD David L. Williams, MD (Senior Status) Jeffrey V. Winston, MD David M. Winters, MD (Senior Status) David L. Wirta, MD Barry J. Wolstan, MD Wilson C. Wu, MD, PhD Michael C. Yang, MD Patrick C. Yeh, MD Richard H. Yook, MD (Senior Status) Peter D. Zeegen, MD (Senior Status)

Appendices | Stein Eye Institute 111 Residents and Fellows

Medical Retina Medical Retina Residents and Fellows and Ophthalmic Genetics and Ophthalmic Genetics Siya Huo, MD M. Zubair Yameen Arain, MD Luca Zatreanu, MD Pakistan Residents Giulia Corradetti, MD Neuro-Ophthalmology Third-Year Residents Italy 2015–2018 None Juan Pablo Davila Gonzalez, MD Mexico Todd H. Driver, MD Orbital and Ophthalmic Plastic Surgery Marco Nassisi, MD Juliet O. Essilfie, MD (Doheny Eye Center UCLA) Sean F. Garrity, MD Christopher Lo, MD Italy Wei “Wayne” Gui, MD Sathyadeepak Ramesh, MD Neuro-Ophthalmology Shawn Lin, MD Pathology (Eye) Erika T. Tanaka Friesen, MD None Diana Lee, MD Ye Elaine Wang, MD Orbital and Ophthalmic David Xu, MD Pediatric Ophthalmology Plastic Surgery and Strabismus Second-Year Residents Hamzah Mustak, MD 2016–2019 Shauna Berry, DO South Africa Azam Qureshi, MD Christine L. Bokman, MD Shoaib Ugradar, MD United Kingdom Benjamin C. Campbell, MD Uveitis and Inflammatory Elisha C. Garg, MD Eye Disease Pediatric Ophthalmology Kirk K. Hou, MD None Narisa Rattanalert, MD Patrick J. Lee, MD Thailand Vitreoretinal Diseases and Surgery Xiongfei Lu, MD Muhammad Ali, MBBS Eric Shieh, MD Nikisha Kothari, MD Pakistan Jason “Mingyi” Huang, MD Victoria L. Tseng, MD, PhD (EyeSTAR) Uveitis Christian Sanfilippo, MD First-Year Residents Sanket U. Shah, MD None 2017–2020 Visual Physiology Judd Cahoon, MD None Tamara L. Lenis, MD, PhD (EyeSTAR) International Fellows Cameron Pole, MD Cornea Research Vitreoretinal Diseases and Surgery David T. Stark, MD, PhD (EyeSTAR) Tulika Chauhan, MD Amirhossein Hariri, MD William Stoddard, MD India (Doheny Eye Center UCLA) Sandip Suresh, MD Huong Duong, MD Iran Qing Wang, MD, PhD (EyeSTAR) Thailand Anibal Francone, MD Madeline Yung, MD Erick Encampira Luna, MD Argentina Mexico Seong Joo Shin, MD South Korea EyeSTAR Trainees Comprehensive Ophthalmology/ Vidal Soberon Ventura, MD Cataract (Retina Oncology) Adrian Au, MD None Mexico Tamara L. Lenis, MD Anh H. Pham, MD, PhD Glaucoma David Stark, MD, PhD Goichi Akiyama, MD, PhD Predoctoral Michel Sun, MD, PhD (Doheny Eye Center UCLA) Research Fellows Japan Victoria Tseng, MD, PhD Kevin Eden Ramin Daneshvar, MD Qing Wang, MD, PhD W. Blake Gilmore Iran Khristopher Griffis Nima Fatehi, MD Clinical Fellows Iran Roni Hazim Ji Hyun Kim, MD Norianne Ingram Cornea/External Ocular Diseases Margaux Kreitman and Refractive Surgery South Korea Alessandro Rabiolo, MD Alan Le Pejman Bakhtiary, MD Italy Eunice Ng Glaucoma Joseph Park Thomas Avallone, MD Katie Pohl Janet Lee, MD Gabriel Pollock Wen-Shin Lee, MD Gabriela Sendek Christine V. Nguyen, MD Tongzhou Xu (Doheny Eye Center UCLA)

112 Stein Eye Institute | Appendices Residents and Fellows

Postdoctoral Research Fellows

Zachary Balmuth-Loris, PhD Edouard Baulier, PhD Abhishek Chadha, PhD Doug Chung, PhD Aurelie Dos Santos, PhD Matthias Elgeti, PhD Antonio Escudero Paniagua, PhD Sheyla Gonzalez-Garrido, PhD Nermin Kady, PhD Michael Lerch, PhD Ala Morshedian, PhD Jonathan Rodriguez, PhD Charles Avery Sader, PhD Kwang Sup “Andrew” Shin, PhD Kaushali Thakore-Shah, PhD Soh Youn Suh, MD Ankita Umapathy, PhD Stefanie Volland, PhD Yanjie Wang, PhD Chi Zhang, PhD Wenlin Zhang, PhD

Appendices | Stein Eye Institute 113 Appendices Research Contracts and Grants

Active Funding July 1, 2017–June 30, 2018

Vision Science Grants Total Award Anthony J. Aldave, MD Identification and Characterization of the Genetic Basis of PPCD National Eye Institute Duration: 12/1/12–11/30/17 $250,000 Vision Restoration with a Collagen Crosslinked Boston Keratoprosthesis Unit Department of Defense Sub-award from Massachusetts Eye and Ear Infirmary Duration: 9/1/15–8/31/17 $50,492

Suraj P. Bhat, PhD Childhood Cataractogenesis: Heterogeneity of Gene Expression National Eye Institute Duration: 1/1/15–12/31/18 $250,000

Joseph Caprioli, MD Clinical Research Program in Glaucoma Simms-Mann Family Foundation Duration: 7/1/14–6/30/18 $50,000 The Efficacy and Safety of Bimatoprost SR in Patients with Open-Angle Glaucoma or Ocular Hypertension Allergan Pharmaceutical Corp. Duration: 4/22/15–1/31/19 $149,974

Anne L. Coleman, MD, PhD UCLA Mobile Eye Clinic Child Vision Program LA County Children and Families First (First 5 LA) Duration: 7/1/13–9/30/17 $1,082,500 Ocular Hypertension Treatment Study 20-Year Follow-Up: Clinical Center Grant National Eye Institute Sub-award from Washington University Duration: 7/1/15–6/30/18 $9,483

Joseph L. Demer, MD, PhD Biomechanical Analysis in Strabismus Surgery National Eye Institute Duration: 5/1/16–4/30/20 $384,867

Sophie X. Deng, MD, PhD Regeneration of a Normal Corneal Surface by Limbal Stem Cell Therapy California Institute for Regenerative Medicine (CIRM) Duration: 8/1/16–11/30/18 $922,786

Gordon L. Fain, PhD Physiology of Photoreceptors National Eye Institute Duration: 8/1/17–7/31/21 $250,000

114 Stein Eye Institute | Appendices Research Contracts and Grants

Debora B. Farber, PhD, DPhhc Edouard Baulier, PhD Patient-Derived iPSCs, CRISPR/Cas and RPE-Derived Exosomes for the Treatment of Ocular Albinism Vision of Children Duration: 6/1/16–5/31/19 $163,783

Lynn K. Gordon, MD, PhD Diversity and Inclusion Culture and Climate Self-Assessment Tool and Scorecard Association of American Medical Colleges Duration: 9/15/17–9/14/18 $12,000

Michael B. Gorin, MD, PhD IPS Model for Retinal Hemangioma Pathogenesis VHL Family Alliance Duration: 10/1/16–9/30/18 $50,000 Natural History of the Progression of X-Linked Retinitis Pigmentosa NightstaRx Duration: 9/28/17–8/31/19 $135,770

Gary N. Holland, MD Macular Edema Treatment Trials Associated with MUST (META-MUST) National Eye Institute Sub-award from Johns Hopkins University Duration: 9/30/14–1/31/18 $39,180 Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study (SITE) University of Pittsburgh Duration: 3/2/16–3/2/21 Non-monetary Contract Systemic Immunosuppressive Therapy for Eye Disease (Cancer Surveillance and Research Branch/CCR) University of Pittsburgh Duration: 3/2/16–3/2/21 Non-monetary Contract Long-term Suppressive Valacyclovir Treatment for Herpes Zoster Ophthalmicus New York University Duration: 4/3/17–7/31/21 $339,898 Multicenter Uveitis Steroid Treatment (MUST) Trial National Eye Institute Sub-award from Johns Hopkins University Duration: 6/1/12–4/30/18 $14,354

Joseph Horwitz, PhD Analysis of Lens Crystallins and Cataractous Mutants at High Hydrostatic Pressure National Eye Institute Duration: 4/1/14–3/31/19 $150,000

Alex A. Huang, MD, PhD Discovery and Characterization of Anterior Sclera Pathology in Glaucoma National Eye Institute Duration: 9/30/14–9/29/19 $203,981 Research to Prevent Blindness Career Development Award Research to Prevent Blindness, Inc. Duration: 1/1/16–12/31/19 $75,000

Appendices | Stein Eye Institute 115 Research Contracts and Grants

Wayne L. Hubbell, PhD Molecular Basis of Membrane Excitation National Eye Institute Duration: 5/1/15–4/30/20 $311,375

Michael Ip, MD Studies of Comparative Treatments in Retinal Vein Occlusion 2 (SCORE 2) National Eye Institute Sub-award from Penn State University Duration: 6/16/16–3/31/19 $47,631

Bartly J. Mondino, MD RPB Unrestricted Grant Research to Prevent Blindness, Inc. Duration: 1/1/12–12/31/18 $115,000

Stacy L. Pineles, MD Integrating Perceptual Learning Approaches into Effective Therapies for Low Vision National Eye Institute Sub-award from University of California Riverside Duration: 9/1/13–7/31/18 $28,921 Pediatric Eye Disease Investigator Group (PEDIG) JAEB Center for Health Research Duration: 2/28/11–12/31/18 $11,220

Roxana Radu, MD The Role of Complement in Recessive Stargardt Disease National Eye Institute Distribution: 8/1/15–7/31/20 $250,000

SriniVas R. Sadda, MD Non Exudative Age-Related Macular Degeneration Imaged with Swept Source Optical Coherence Tomography Boston Image Reading Center Duration: 2/1/18–2/28/21 $42,520 AREDS 2 10-Year Follow-up Emmes Corporation Duration: 11/1/17–2/31/18 $20,790

Alfredo A. Sadun, MD, PhD Samuel Asanad Fall 2017 RPB Medical Student Eye Research Fellowship Research to Prevent Blindness, Inc. Duration: 1/1/18–12/31/18 $30,000

Alapakkam P. Sampath, PhD Molecular Basis of Photoreceptor Wiring National Eye Institute (Multi-PI award with Scripps Clinic and Research Foundation) Duration: 5/1/17–4/30/22 $91,444 Analyses of Retinal Circuits After Rod Rescue in a Mouse Model of Human Blindness National Eye Institute (Multi-PI award with University of Southern California) Duration: 9/1/16–8/31/21 $95,673 Vision Science Training Program National Eye Institute Duration: 9/1/17–8/31/18 $215,081

116 Stein Eye Institute | Appendices Research Contracts and Grants

David Sarraf, MD Diabetic Retinopathy Clinical Research Network JAEB Center for Health Research Duration: 6/13/17–12/31/18 Non-monetary Contract

Gabriel H. Travis, MD The Role of Müller Cells in Visual Pigment Regeneration National Eye Institute Duration: 7/1/13–6/30/18 $326,429 Instrumentation Grant for Stein Eye Investigators Bruce Ford and Anne Smith Bundy Foundation Duration: 8/16/11–8/15/18 $100,000 Functional Characterization of RGR-OPSIN in Retinal Müller Cells National Eye Institute Distribution: 9/1/15–8/31/18 $250,000

Irena Tsui, MD Ophthalmic Manifestations of Congenital Zika Virus Infection National Eye Institute Duration: 3/1/17–2/28/19 $25,932

David S. Williams, PhD The Photoreceptor Cilium National Eye Institute Duration: 5/1/13–4/30/19 $250,000 Photoreceptor Disk Membrane Morphogenesis National Eye Institute Sub-award from University of California, Santa Barbara Duration: 4/1/15–3/31/19 $124,797 Stein Eye Institute Core Grant for Vision Research National Eye Institute Duration: 9/1/15–6/30/20 $533,453 Gene Editing of the Usher 1B Gene Foundation Fighting Blindness Duration: 6/1/17–5/31/18 $100,000 Cellular Mechanisms of Disease in Patient-Specific RPE Cells Foundation Fighting Blindness Sub-award from University of California, San Francisco Duration: 6/1/17–5/31/18 $164,930 RPE Cell Biology, Aging, and Disease National Eye Institute Duration: 9/1/17–5/31/22 $296,846

Xian-Jie Yang, PhD Neuroprotection Mechanism for Photoreceptors National Eye Institute Duration: 5/1/16–4/30/21 $250,000

Appendices | Stein Eye Institute 117 Research Contracts and Grants

Professional Research Series Navid Amini, PhD EyeSee: Mobile Assistive Technology for Hemianopic Patients Vodafone-US Foundation Duration: 7/1/16–6/30/19 $66,675

Sonia Guha, PhD Role of Doublecortin in Axonal Misrouting in OA1 -/- Mice Vision of Children Duration: 7/1/14–3/15/20 $152,236

Rustum Karanjia, MD, PhD Photopic Negative Response (PhNR) as an Objective Outcome Measures in Mitochondrial Disease United Mitochondrial Disease Foundation Duration: 12/1/17–11/30/19 $50,000

Anna Matynia, PhD Targeted Hsp70 as a Therapeutic for Central Retinal Artery Occlusion Rubicon Biotechnology Duration: 9/30/17–9/30/18 $40,400

Alejandra Young, PhD Identification of the OA1 Molecule Partners Critical for Axonal Guidance of RGCs Growth Cones (Proposal Continuation of Grant #20142326) Vision of Children Duration: 11/1/13–7/14/20 $195,525

Residents and Fellows Abhishek Chadha, PhD (Vision-Science Postdoctoral Fellow) Functional Characterization of MY07A in Retinal Tissue National Eye Institute Duration: 7/1/16–6/30/19 $57,066

Roni Hazim (Vision-Science Predoctoral Fellow) CFH in RPE Cell Biology and Disease National Eye Institute Duration: 3/1/17–8/31/18 $26,810

Wenlin Zhang, MD, PhD Transcriptome Analysis of the Metabolic Reprogramming in SLC4A11 Associated Congenital Hereditary Endothelial Dystrophy Knights Templar Eye Foundation, Inc. Duration: 7/1/17–12/31/18 $65,000

Clinical Trials Michael B. Gorin, MD, PhD A Single-Masked, Randomized, Controlled, Parallel Group, Phase 3 Clinical Trial of Retinal Gene Therapy for Choroideremia Using an Adeno-Associated Viral Vector Encoding Rab Escort Protein 1 NightstaRx Duration: 6/13/18–6/13/21 $96,333

118 Stein Eye Institute | Appendices Research Contracts and Grants

Jean-Pierre Hubschman, MD A Ph 2 Multicenter Randomized Clinical Trial of Ciliary Neurotrophic Factor for Macular Telangiectasia Type 2 Lowy Medical Research Institute Duration: 8/6/14–6/30/18 $750 Extension Study of NT-501 Ciliary Neurotrophic Factor Implant for Macular Telangiectasia Lowy Medical Research Institute Duration: 8/14/17-6/30/22 $29,878

Kenneth L. Lu, MD Using Pattern ERG to Objectively Measure Contrast Sensitivity Associated with Intraocular Lenses: Study Design Bausch and Lomb Duration: 11/1/17–6/30/19 $36,661

Tara A. McCannel, MD Phase 1B Open-Label, Single Ascending Dose Clinical Trial to Evaluate the Safety of Two Dose Levels of Light-Activated AU-011 for Treatment of Subjects with Small to Medium Primary Choroidal Melanoma Aura Biosciences, Inc. Duration: 9/28/17–9/28/19 $72,909

Peter A. Quiros, MD A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered by Single or Multi-Dose Intravitreal Injection(s) to Subjects with Acute Nonarteritic Anterior Ischemic Optic Neuropathy Quark Pharmaceuticals, Inc. Duration: 8/4/16–8/4/19 $1,600

Alfredo A. Sadun, MD, PhD A Prospective, Randomized, Double-Masked, Vehicle-Controlled, Phase 2 Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of MTP-131 TOPI Stealth Biotherapeutics Inc. Distribution: 2/12/16–2/12/18 $13,876 Reality LHON Registry GenSight Biologics Duration: 1/16/18–9/1/19 $45,810 Long-term Follow-up of ND4 LHON Subjects Treated with GS010 Ocular Gene Therapy in the RESCUE or REVERSE Phase III Clinical Trials GenSight Biologics Duration: 1/3/18–1/3/21 $474,754

Steven D. Schwartz, MD A Phase 2B Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Zimura (Complement CS Inhibitor) Compared to Sham in Subjects with Autosomal Recessive Stargardt Disease Ophthotech Corporation Duration: 4/10/18–4/10/21 $305,751

Irena Tsui, MD RAINBOW Study: A Randomized Controlled Study Evaluating the Efficacy and Safety of RAnibizumab Compared with Laser Therapy for the Treatment of INfants BOrn Prematurely with Retinopathy of Prematurity Novartis Pharmaceuticals Duration: 4/3/17–7/31/18 $38,953

Appendices | Stein Eye Institute 119 Research Contracts and Grants

Research Contracts and Grants Active Funding Administered by Doheny Eye Center UCLA

Vision Science Grants Alex A. Huang, MD, PhD Structure and Function of Aqueous Humor Outflow American Glaucoma Society and Allergan Young Clinician Scientist Award Duration: 3/17/15–9/30/2018 $20,000/initial year Glaukos Research (Outflowing Imaging) Glaukos Corporation Duration: 10/17/15–9/30/2018 $10,000/two years

SriniVas R. Sadda, MD Multimodal Image Analysis in Age-Related Macular Degeneration Macula Vision Research Foundation Duration: 1/1/15–12/31/17 $100,000/year Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine Applications Eyenuk, Inc. Sub-award on NEI EY026864 Duration: 8/1/16–7/31/18 $47,771 High Resolution Retinal Imaging by Fourier Ptychography CalTech Sub-award on NEI Grant EY026228 Duration: 4/1/16–3/31/19 $25,000 Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine Application Eyenuk, Inc. Sub-award on NEI Grant SB1EY027241 Duration: 9/30/16–7/31/19 $19,108

Alfredo A. Sadun, MD, PhD Psychological and Environmental Effectors of mtDNA Disease Penetrance Children’s Hospital of Philadelphia Duration: 10/1/16–6/30/18 $20,000/initial year

Deming Sun, MD Role of IL-17+ Autoreactive T Cells in Experimental Autoimmune Uveitis (EAU) National Eye Institute Duration: 9/1/09–7/31/19 $274,912

James C. Tan, MD, PhD Karl Kirchgessner Foundation Vision Research Grant The Karl Kirchgessner Foundation Duration: 10/17/09–Open $50,000 Fibrillin-1 and TGFB2 Abnormality Models PAOG Pathogenesis and Treatment National Eye Institute Duration: 9/30/17–5/31/20 $250,000 Contractile Modulation of Distal Aqueous Humor Drainage National Eye Institute Duration: 6/1/18–5/31/20 $150,000

120 Stein Eye Institute | Appendices Research Contracts and Grants

Clinical Trials SriniVas R. Sadda, MD Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order Amish University of Pennsylvania Sub-award on NEI Grant EY023164 Duration: 2/1/13–1/31/18 $60,784

Research Contracts and Grants Totals Reported in Previous Years

Vision Science Grants Anthony J. Aldave, MD Effect of Corneal Preservation Time on Long-Term Graft Success JAEB Center for Health Research Duration: 3/6/12–8/31/17 Genetic Factors in Keratoconus National Eye Institute Sub-award from Cedars-Sinai Medical Center Duration: 12/1/14–2/28/18

Dean Bok, PhD Analysis of ARMS2 and HTRA 1 Gene Expression in Retinal Pigment Epithelium Helen Keller Foundation for Research and Education Inc. Duration: 6/1/16–5/31/18

Anne L. Coleman, MD, PhD UCLA Mobile Eye Clinic Child Vision Program LA County Children and Families First (First 5 LA) Duration: 7/1/13–9/30/17

Sophie X. Deng, MD, PhD Ex Vivo Expansion of Human Limbal Stem Cells for Transplantation National Eye Institute Duration: 9/1/12–8/31/18

Lynn K. Gordon, MD, PhD Pd-Ligand, a Paradoxical Role in Experimental Uveitis Pathogenesis and Therapy National Eye Institute Duration: 4/1/15–3/31/18

Michael B. Gorin, MD, PhD Genetics-Based Testing of Functional and Structural Endophenotypes for Pre- and Early-Age-Related Macular Degeneration Arnold and Mabel Beckman Foundation Duration: 7/1/14–6/30/18 Natural History of the Progression of Choroideremia Study NightstaRx Duration: 6/18/15–4/11/18

Steven Nusinowitz, PhD Michael B. Gorin, MD, PhD (Co-Principal Investigator) Scotopic Critical Flicker Fusion in Preclinical AMD BrightFocus Foundation Duration: 7/1/15–6/30/18

Appendices | Stein Eye Institute 121 Research Contracts and Grants

Stacy L. Pineles, MD RPB Walt and Lilly Disney Award for Amblyopia Research Research to Prevent Blindness, Inc. Duration: 7/1/14–6/30/19

Daniel B. Rootman, MD, MS Hyaluronic Acid Gels for Upper Lid Retraction in Thyroid Eye Disease Galderma Laboratories L.P. Duration: 6/8/16–7/11/18

Alapakkam P. Sampath, PhD Experimental and Clinical Investigations of Retinal Stimulation National Eye Institute Sub-award from University of Michigan Duration: 3/1/17–2/28/18

SriniVas R. Sadda, MD Sears, Connie: Re-engineering the Screening and Staging of Diabetic Retinopathy Research to Prevent Blindness, Inc. Duration: 1/1/17–12/31/18

David Sarraf, MD DRCR Funding Addendum JAEB Center for Health Research Duration: 6/13/17–12/31/18 DRCR Protocol W: Intravenous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk JAEB Center for Health Research Duration: 6/13/17–12/31/18

Federico G. Velez, MD An Observational, Multicenter Study of the Prevalence of Cerebrotendinous Xanthomatosis in Patient Population Diagnosed with Early Onset Idiopathic Bilateral Cataract Retrophin, Inc. Duration: 1/6/16–12/6/19

Clinical Trials Joseph Caprioli, MD The Efficacy and Safety of Bimatoprost SR in Patients with Open-Angle Glaucoma or Ocular Hypertension Allergan Pharmaceutical Corp. Duration: 4/22/15–1/31/19 A Randomized Study Comparing the Safety and Efficacy of the InnFocus MicroShunt® Glaucoma Drainage System to Standard Trabeculectomy in Subjects with Primary Open Angle Glaucoma Protocol INN-005 Innfocus Inc. Duration: 2/4/16–2/4/18

Brian A. Francis, MD, MS Study for Benchmarking the Management of Ophthalmic Diseases Using the Diopsys Visual Evoked Potential/Pattern ERG/ERG Protocol Diopsys Inc. Duration: 2/21/16–1/31/19

122 Stein Eye Institute | Appendices Research Contracts and Grants

Robert Alan Goldberg, MD A Multicenter Double-Masked Placebo-Controlled Efficacy and Safety Study of RV001 Premier Research International, LLC Duration: 4/16/13–8/31/17

Michael B. Gorin, MD, PhD A Phase 2 Multicenter, Double-Masked, Randomized, Placebo-Controlled Study to Investigate the Long Term Safety, Tolerability, Pharmacokinetics and Effects of ALK-001 on the Progression of Stargardt Disease Alkeus Pharmaceuticals Inc. Duration: 5/23/16–8/22/18

Jean-Pierre Hubschman, MD A Phase 3, Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Intravitreous Administration of Fovista (Anti-PDGF-B Pegylated Aptamer)…ARMD Ophthotech Corporation Duration: 12/4/13–9/27/17

Jean-Pierre Hubschman, MD Steven D. Schwartz, MD (Previous Principal Investigator) A Natural History of Macular (Parafoveal) Telangiectasia Lowy Medical Research Institute Duration: 9/1/05–12/31/18

Colin A. McCannel, MD A Phase II, Multicenter, Randomized, Active Treatment-Controlled Study of the Efficacy and Safety of the Ranibizumab Port Delivery System for Sustained Delivery of Ranibizumab in Patients with Subfoveal Neovascular Age-Related Macular Degeneration Genentech, Inc. Duration: 9/22/15–6/12/19

Kevin M. Miller, MD Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects Clinical Research Consultants, Inc. Duration: 6/12/14–1/9/19

SriniVas R. Sadda, MD Safety and Efficacy of Abicipar Pegol (AGN-150998) in Patients with Neovascular Age-Related Macular Degeneration CEDAR Study Allergan Pharmaceutical Corp. Duration: 3/8/16–5/31/20

Alfredo A. Sadun, MD, PhD Emergency Administration of EPI-743 to a Single Patient with Leber’s Hereditary Optic Neuropathy Edison Pharmaceuticals, Inc. Duration: 10/17/14–9/26/18 A Randomized, Double-Masked, Sham-Controlled, Pivotal Clinical Trial to Evaluate the Efficacy of a Single, Intravitreal Injection of GS010 (RAAV2/2-ND4) A GenSight Biologics Duration: 1/11/16–11/7/18

Appendices | Stein Eye Institute 123 Research Contracts and Grants

A Randomized, Double-Masked, Sham-Controlled, Pivotal Clinical Trial to Evaluate the Efficacy of a Single, Intravitreal Injection of GS010 (RAAV2/2-ND4) B GenSight Biologics Duration: 1/12/16–11/7/18

David Sarraf, MD A Phase III, Multicenter, Randomized Double-Masked Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients with Geographic Atrophy Secondary to ARMD Genentech, Inc. Duration: 11/21/14–9/27/18 Safety and Efficacy of Abicipar Pegol (AGN-150998) in Patients with Neurovascular Age-Related Macular Degeneration Sequoia Study Allergan Pharmaceutical Duration: 4/14/16–5/31/20 The IAI-OCTA Study, or: Microvascular Structure and Morphology of Neovascular Membranes in Age Related Macular Degeneration After Intravitreal Aflibercept Injection Therapy Using OCT-Angiography Analysis Regeneron Pharmaceuticals, Inc. Duration: 3/28/17–3/28/20 A Randomized, Double-Masked, Active Controlled, Phase 2 Study of the Efficacy, Safety, and Tolerability of Repeated Doses of Intravitreal REGN910-3 in Patients with Neovascular Age-Related Macular Degeneration Regeneron Pharmaceuticals, Inc. Duration: 9/8/16–9/8/19 A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Lampalizumab in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration Who Have Completed a Roche-Sponsored Study Genentech, Inc. Duration: 11/16/16–11/16/19 Intravitreous Anti-VEGF Treatment for Prevention of Vision Threatening Diabetic Retinopathy in Eyes at High Risk, Protocol W JAEB Center for Health Research Duration: 8/1/16–7/31/21

Steven D. Schwartz, MD A Multicenter, Prospective Epidemiologic Study of the Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration: Protocol Number GX29633 Genentech, Inc. Duration: 10/18/16–8/1/20 Long Term Follow Up to a Phase I/II, Open-Label, Multi-Center Prospective Study to Determine the Safety and Tolerability of Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial Cells in Patients with Stargardt’s Macular Dystrophy Astellas Institute for Regenerative Medicine (formerly Advanced Cell Technology and Ocata Therapeutics) Duration: 3/23/11–1/09/19 A Multicenter, Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Lampalizumab in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration Who Have Completed a Roche-Sponsored Study Genentech, Inc. Duration: 10/27/16–10/27/19

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Long-Term Follow-Up to a Phase I/II, Open-Label, Multicenter, Prospective Study to Determine the Safety and Tolerability of Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cells in Patients with Advanced Dry AMD Astellas Institute for Regenerative Medicine (formerly Advanced Cell Technology and Ocata Therapeutics) Duration: 4/5/11–6/12/19 A Multiple-Center, Multiple-Dose, Randomized, Active, Comparator- Controlled, Double-Masked, Parallel Group, 28-Week Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO6867461 Administered Intravitreally in Patients with Diabetic Macular Edema Hoffmann-La Roche (Include Roche Molecular Systems, Inc.) Duration: 10/18/16–11/21/17 A Phase III, Multicenter, Randomized Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients with Geographic Atrophy Secondary to ARMD Genentech, Inc./Hoffman-La Roche Inc. Duration: 11/18/14–9/27/18 A Phase 2, Double-Masked, Randomized, Parallel Group, Sham Surgery Placebo Controlled Multicenter Study to Evaluate Systemic Immunosuppression Regimens as Graft Rejection Prophylaxis Following Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial Cells in Patients with Geographic Atrophy Secondary to ARMD Astellas Institute for Regenerative Medicine (formerly Advanced Cell Technology and Ocata Therapeutics) Duration: 10/7/15–10/7/17

Federico G. Velez, MD A Randomized, Double-Masked, Parallel-Group, Phenylephrine Controlled Study of the Effect of OMS302 Added to Standard Irrigation Solution on Intraoperative Pupil Diameter and Acute Postoperative Pain in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction with or Without Lens Replacement Omeros Inc. Duration: 8/6/15–8/6/17 A Randomized, Multicenter, Double Masked, Parallel-Group Study Assessing the Safety and Efficacy of Loteprednol Etabonate Ophthalmic Gel, 0.5% Versus Prednisolone Acetate Ophthalmic Suspension, 1% for the Treatment of Intraocular Inflammation Following Surgery for Childhood Cataract Bausch and Lomb Duration: 9/17/15–9/17/17

Appendices | Stein Eye Institute 125 Appendices

126 Stein Eye Institute | Appendices Appendices Clinical Research Studies

n the 2017–2018 academic year, Genetic Basis of Posterior Eye Infections IUCLA Department of Ophthal Polymorphous Corneal Dystrophy and Inflammations This study seeks to identify the mology faculty conducted over 80 Corneal Endothelial Cell Changes gene(s) responsible for posterior clinical research studies to better un in Children with Uveitis polymorphous dystrophy, an inherited derstand the eye and its ocular disor corneal endothelial disorder that may This is a prospective study to evalu ders, as well as to evaluate new and result in irreversible corneal swell ate the cornea, specifically endothelial cells, in children with uveitis. Uveitis potentially sight-saving treatments. ing and loss of vision. Investigators: Anthony J. Aldave, MD, and Gary N. may lead to a change in the number Holland, MD of endothelial cells and their shape. Cornea and External Eye Specular microscopy, which is a non Disease Identifying Novel Genes invasive corneal-imaging technique, for Fuchs Corneal helps to estimate changes in corneal Analysis of the Corneal and Endothelial Dystrophy endothelium long before clinical Limbal Epithelial Changes in signs of corneal damage. Investiga Investigators are working to identify Limbal Stem Cell Deficiency Using tors: Joseph Caprioli, MD, JoAnn A. the gene(s) responsible for Fuchs cor In Vivo Confocal Microscopy Giaconi, MD, Gary N. Holland, MD, neal endothelial dystrophy, an inherited Investigators are working to establish Simon K. Law, MD, PharmD, and disorder that may result in irreversible a system for diagnosing limbal stem Ralph D. Levinson, MD corneal swelling and loss of vision. cell deficiency at a cellular level by Investigators: Anthony J. Aldave, MD, correlating the information from impres Corticosteroids for Gary N. Holland, MD, and Bartly J. sion cytology tests, confocal micros Uveitic Macular Edema Mondino, MD copy pictures, and medical records. This research study compares three Investigators: Anthony J. Aldave, MD, treatments for macular edema in and Sophie X. Deng, MD, PhD Keratoprosthesis Implantation in Patients with patients who have uveitis. Macular Corneal Opacification edema is swelling of the retina at Effect of Corneal Preservation Time the back of the eye, and it can cause This study aims to determine the suc on Long-Term Graft Success vision loss. The standard treatment is cess rate of keratoprosthesis (artificial This study evaluates the effect of pres to inject corticosteroid drugs next to corneal) transplantation for visual ervation time on corneal transplants. It the eye or directly into the eye. Investi rehabilitation in patients with corneal will compare the preservation time up gators: Gary N. Holland, MD, and Colin opacification. Investigators: Anthony J. to the FDA limit of 14 days and hopes A. McCannel, MD Aldave, MD, and Gary N. Holland, MD to determine that longer preservation time does not adversely impact graft Factors Related to the Severity Ocular Surface Microbiome Study success and endothelial cell density. of Ocular Toxoplasmosis This study aims to investigate and Investigators: Anthony J. Aldave, MD, Toxoplasmosis is a common parasitic understand the normal ecosystem of and Sophie X. Deng, MD, PhD disease that can cause a vision- microbes that live on the eye’s surface threatening infection of the retina. and how their ecological system Evaluation of Corneal Individuals with and without ocular changes and responds to routine eye Cross-Linking Keratoprosthesis toxoplasmosis are being evalu care and treatments. Investigators: Carrier Tissue ated with a blood test to determine Hugo Hsu, MD, Vikas Chopra, MD, This clinical trial evaluates the safety whether (1) people can have a genetic and Gad Heilweil, MD and efficacy of corneal collagen cross- predisposition to severe disease when linking the keratoprosthesis carrier tis infected with the parasite, or (2) there sue in subjects who are candidates for is a particular strain of parasite that high-risk keratoprosthesis implantation causes more severe disease than because of a history of corneal melts, others. Investigators: Gary N. Holland, sterile corneal ulcers, or autoimmune MD, and Ralph D. Levinson, MD diseases (eg, Stevens-Johnson syn drome, ocular cicatricial pemphigoid). Investigators: Anthony J. Aldave, MD, and Sophie X. Deng, MD PhD

Appendices | Stein Eye Institute 127 Appendices Clinical Research Studies

Macular Edema Ranibizumab v. Effect of Yoga on Glaucoma Ocular Biometric Measurements Intravitreal Anti-inflammatory The purpose of this study is to in Angle-Closure Glaucoma Therapy (MERIT) Trial examine the practice of yoga and its The purpose of this study is to deter The MERIT Trial was designed to ability to improve a patient’s vision by mine the potential contributing factors determine which intravitreal therapy relieving stress and reducing eye pres in angle-closure patients of different offers the best balance of effective sure. Investigator: Anne L. Coleman, ethnicities and to determine predic ness and tolerability in treating per MD, PhD tive factors for this type of glaucoma. sistent uveitic macular edema in eyes Investigators: Joseph Caprioli, MD, with controlled uveitis but persistent Evaluating a Microshunt for the Anne L. Coleman, MD, PhD, Simon macular edema, specifically by com Treatment of Glaucoma K. Law, MD, PharmD, and Kouros paring the relative efficacy and safety This study is to assess the safety and Nouri‑Mahdavi, MD of intravitreal ranibizumab (Lucentis®) efficacy of a microshunt when used and intravitreal methotrexate to to lower intraocular pressure (IOP) Ocular Hypertension intravitreal dexamethasone implant in subjects with primary open angle Treatment Study (Ozurdex®). Investigators: Gary N. glaucoma whose IOP is not controlled Since topical hypotensive medica Holland, MD, Colin A. McCannel, MD, when using maximum-tolerated tions are safe and effective in delay and Pradeep S. Prasad, MD glaucoma medications. Investiga ing or preventing primary open angle tors: Joseph Caprioli, MD, Anne L. glaucoma, this study is examining Zoster Eye Disease Study (ZEDS) Coleman, MD, PhD, JoAnn A. Giaconi, whether other forms of treatment The purpose of this study is to find MD, Simon K. Law, MD, PharmD, and can be deferred with little or no pen out whether one year of a low dose of Brian A. Francis, MD, MS alty. Investigator: Anne L. Coleman, valacyclovir reduces complications of MD, PhD shingles affecting the eye. The study Evaluating the Efficacy and Safety will involve two groups of partici of an Investigational Eye Drop Ocular Imaging in pants who have eye problems due to in Patients with Open-Angle Simulated Microgravity shingles. One group will receive daily Glaucoma or Ocular Hypertension Consideration needs to be given to valacyclovir medication and the other This study evaluates the intraocular how microgravity may influence the group will receive a placebo. Investiga pressure-lowering efficacy and biology and well-being of astronauts. tors: Gary N. Holland, MD, Anthony safety of two dose strengths of an Astronauts returning from space expe J. Aldave, MD, Sophie X. Deng, MD, investigational eye drop in patients rience visual disturbance in addition to PhD, and John A. Irvine, MD with open-angle glaucoma or ocular pathological changes that affect the hypertension after initial and repeated eye. This study noninvasively esti administrations. Investigators: Joseph mates intracranial pressure in study Glaucoma Caprioli, MD, Anne L. Coleman, MD, participants and obtains intraocular/ Analysis of Visual Function PhD, JoAnn A. Giaconi, MD, Simon vascular imaging in simulated micro in Glaucoma K. Law, MD, PharmD, and Kouros gravity environments. Investigator: Nouri‑Mahdavi, MD Alex A. Huang, MD, PhD The purpose of this study is to estab lish electrophysiological benchmarks Eye Health Imaging Study Optic Nerve Appearance in using the Visual Evoked Potential/ Age-Related Macular Degeneration Pattern Electroretinogram protocols The purpose of this study is to expand of populations with glaucoma before the normative database for the In order to evaluate the relationship treatment and after treatment. Investi Heidelberg Spectralis OCT by collect between macular degeneration and gators: Brian A. Francis, MD, MS, Alex ing ophthalmic data from healthy eyes optic nerve change, digital imaging A. Huang, MD, PhD, Vikas Chopra, of people of Hispanic/Latino, Asian, technology and photography are being MD, SriniVas R. Sadda, MD, and and African American descent. Inves used to assess the structural appear Gad Heilweil, MD tigators: Joseph Caprioli, MD, and ance of the optic nerve in patients Kouros Nouri-Mahdavi, MD with age-related macular degen Clinical Measurements of the eration. Investigator: Simon K. Law, Optic Nerve in Glaucoma Glaucoma Imaging Study MD, PharmD The goal of this study is to develop This study is evaluating different imag novel structural measures of the optic ing techniques and their use in improv nerve and nerve fiber layer, which ing open-angle glaucoma detection. are sensitive and specific for early Investigators: Joseph Caprioli, MD, and progressive glaucomatous optic and Kouros Nouri-Mahdavi, MD nerve damage. Investigators: Joseph Caprioli, MD, Anne L. Coleman, MD, PhD, and Simon K. Law, MD, PharmD

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Role of Pattern Electroretinogram Arm-Mounted Heidelberg Evaluation of a New Drug for (PERG) in Glaucoma OCT-A for Noninvasive Vascular Stargardt Disease This study is researching the elec Zone Imaging in Infants with The study purpose is to find out trophysiological test, pattern elec Retinopathy of Prematurity (ROP) whether a new drug for Stargardt troretinogram (PERG) to determine This study evaluates OCT-A imag disease is safe and effective. There the role of PERG in estimating the ing data on preterm infants who are are currently no proven treatments for risk of future glaucoma progression screened and/or treated for ROP, Stargardt disease, a disease that leads and the reversibility of glaucomatous especially evaluating the potentially to blindness in almost all cases. Inves damage after treatment. The latter beneficial effects of anti-VEGF treat tigators: Michael B. Gorin, MD, PhD, could help clinicians better determine ment on foveal development and and Steven Nusinowitz, PhD to what extent eye pressure needs visual outcomes. Investigators: Alex to be lowered to prevent disease Huang, MD, PhD, and Irena Tsui, MD Extension Study of NT-501 Ciliary progression. Investigators: Joseph Neurotrophic Factor Implant for Caprioli, MD, Anne L. Coleman, MD, Clinical Characterization, Genetic Macular Telangiectasia PhD, JoAnn A. Giaconi, MD, Simon Testing, and Visual Function in The primary objective of this study is K. Law, MD, PharmD, and Kouros Patients with Stargardt Disease to investigate long-term safety and Nouri-Mahdavi, MD Investigators are doing a compre efficacy of the NT-501 implant in par hensive analysis of visual function in ticipants previously enrolled in NTMT Vision-Related Quality of Life and patients diagnosed with Stargardt dis protocols. Investigators: Jean-Pierre Ocular Dominance ease, an early onset form of macular Hubschman, MD, Steven D. Schwartz, This study is designed to evaluate how degeneration caused by a number of MD, and Hamid Hosseini, MD quality of life is impacted by glaucoma mutations in the ABCR gene. They are in relation to eye dominance. It aims performing molecular genetic testing IAI-OCTA Study to determine whether quality of life is to confirm the Stargardt diagnosis and This study is utilizing a new, FDA affected more by glaucoma if it primar better understand the diversity of the approved, non-standard of care tech ily affects the dominant eye. Investi condition. Investigators: Debora B. nology (optical coherence tomography- gators: Joseph Caprioli, MD, Anne L. Farber, PhD, DPhhc, Michael B. Gorin, angiography by Optovue) to image Coleman, MD, PhD, JoAnn A. Giaconi, MD, PhD, and Steven Nusinowitz, PhD and evaluate the treatment outcomes MD, and Simon K. Law, MD, PharmD of using standard of care intravitreal Determining the Safety and Aflibercept injections for their approved Efficacy of Renexus in Macular use in patients diagnosed with neo Lens and Cataract Telangiectasia Type 2 vascular age-related macular degen Safety and Effectiveness of This study is assessing the safety eration who are naive to previous the CustomFlex Artificial Iris of the NT-501 implant in patients Anti-VEGF therapies. Investigator: Prosthesis for the Treatment of with macular telangiectasia type 2. David Sarraf, MD Iris Defects The implant, a small capsule of cells that is placed inside the eye, allows Modified Retinal Fundus Camera This study is being conducted to evalu a controlled, sustained release of ate the safety and effectiveness of an This study evaluates a modified retinal CNTF directly to the retina. Investiga fundus camera to see if significant artificial iris prosthesis for the treat tors: Jean-Pierre Hubschman, MD, ment of full or partial aniridia result differences can be found in patients Steven D. Schwartz, MD, and Hamid with choroidal melanoma, age-related ing from congenital aniridia, acquired Hosseini, MD iris defects (including traumatic iris macular degeneration, or diabetic reti defects and mydriasis), or conditions nopathy. Investigator: Irena Tsui, MD Evaluating the Use of an associated with full or partial aniridia, Implant for Patients with such as ocular or oculocutaneous Natural History of the Macular Degeneration albinism and iridocorneal endothelial Progression of Choroideremia (ICE) syndrome, and iris coloboma. This clinical trial determines the This study characterizes the visual Investigators: Anthony J. Aldave, MD, efficacy, safety, and pharmacokinet function and retinal structural changes and Kevin M. Miller, MD ics of ranibizumab delivered through associated with X-linked choroideremia the implant using three ranibizumab- with the intention of determining the formulation arms compared with the best means of measuring disease Macula, Retina, and Vitreous control arm in patients with subfoveal progression and the rate of natural neovascular (wet) age-related macular progression for this condition. Inves Analysis for Visual Function in degeneration. The study also evalu tigators: Michael B. Gorin, MD, PhD, Age-Related Macular Degeneration ates the safety of the ranibizumab port and Steven Nusinowitz, PhD The study establishes electrophysi delivery system combination product. ological benchmarks using the visual Screening and randomization visits evoked potential/pattern electroretino will be followed by a treatment period. gram (VEP/PERG) protocols of popula Investigators: Colin A. McCannel, MD, tions with glaucoma before treatment Tara A. McCannel, MD, PhD, Pradeep and after treatment. Investigators: S. Prasad, MD, Michael B. Gorin, MD, SriniVas R. Sadda, MD, Gad Heilweil, PhD, and David Sarraf, MD MD, Brian A. Francis, MD, MS, Alex A. Huang, MD, PhD, and Vikas Chopra, MD

129 Stein Eye Institute | Appendices Appendices | Stein Eye Institute 129 Appendices Clinical Research Studies

Natural History of the Progression Research with Retinal Cells Study of Macular Disease of X-Linked Retinitis Pigmentosa Derived from Stem Cells for Using Spectral Domain Optical This study is to characterize the visual Dry Age-Related Macular Coherence Tomography function and retinal structural changes Degeneration (AMD) Angiography (SD-OCTA) associated with X-linked retinitis pig This study evaluates the long-term The RTVue XR 100 Avanti with SSADA mentosa to determine the best means safety and tolerability of MA09-hRPE will be used to screen patients with of measuring disease progression and cellular therapy in subjects with macular disease as detected with the rate of natural progression for this advanced dry AMD from one to five clinical examination or ancillary test condition. Investigator: Michael B. years following the surgical proce ing, such as with standard OCT, color Gorin, MD, PhD dure to implant the MA09-hRPE cells. fundus photography, fluorescein Investigators: Steven D. Schwartz, angiography, or fundus autofluo Natural History Study of MD, Hamid Hosseini, MD, Jean-Pierre rescence. Investigators: Michael B. Macular Telangiectasia Hubschman, MD, Pradeep Prasad, Gorin, MD, PhD, Colin A. McCannel, The primary study objective is to MD, Irena Tsui, MD MD, David Sarraf, MD, and Steven D. develop a registry of participants with Schwartz, MD MacTel Type 2 (as confirmed by the Research with Retinal Cells Reading Center) who may agree to Derived from Stem Cells for Understanding the Genetics of be contacted for inclusion in future Stargardt Macular Dystrophy Inherited Eye Disorders clinical trials. Investigators: Jean-Pierre This study evaluates the long-term This study searches for the gene(s) Hubschman, MD, Hamid Hosseini, safety and tolerability of MA09- responsible for inherited disorders MD, Allan E. Kreiger, MD, Tara A. hRPE cellular therapy in subjects that are either specific to the eye or McCannel, MD, PhD, Pradeep Prasad, with advanced Stargardt macular are part of the medical condition. The MD, Irena Tsui, MD, and Steven D. dystrophy from one to five years study provides for the clinical charac Schwartz, MD following the surgical procedure to terization of affected individuals and implant the MA09-hRPE cells. Inves at-risk family members, in conjunction Optical Coherence Tomography tigators: Steven D. Schwartz, MD, with molecular genetic testing, to Angiography Images of Hamid Hosseini, MD, Jean-Pierre identify the causative genes and muta Pregnant Women Hubschman, MD, Pradeep Prasad, tions. Investigators: Anthony J. Aldave, This study aims to identify changes MD, and Irena Tsui, MD MD, and Michael B. Gorin, MD, PhD that occur in the retina as a result of gestational associated diseases (eg, Safety and Efficacy of Zimura™ gestational diabetes, high blood pres (Complement C5 Inhibitor) Neuro-Ophthalmology Compared to Sham in Subjects sure, increased myopia) and unknown A Protocol to Follow-up changes that may affect the eyes dur with Autosomal Recessive Stargardt Disease with Patients on Emergency ing gestation and in the 2–3 months Administration of EPI-743 with following birth. Investigator: Irena The objectives of this study are to Leber Hereditary Optic Neuropathy Tsui, MD evaluate the safety and efficacy of EPI-743, a form of vitamin E that has Zimura™ intravitreal injection com been changed to a new compound Optical Coherence Tomography pared to sham in subjects with auto in the laboratory, is an experimental Angiography of Foveal Avascular somal recessive Stargardt disease 1. drug that may improve mitochon Zone in Premature Children Investigators: Steven D. Schwartz, drial function. Mitochondrial disease This prospective study evaluates blood MD, Hamid Hosseini, MD, Jean-Pierre Hubschman, MD, Pradeep Prasad, manifestations appeared to improve vessel development in children and when the EPI-743 was given to cells MD, Irena Tsui, MD adults who are born early and com from a patient with Leber hereditary pares them with children and adults optic neuropathy that were grown in Study for Retinopathy who were not born early, by getting the laboratory. Investigator: Alfredo A. of Prematurity optical coherence tomography (OCT), Sadun, MD, PhD OCT-angiography, color pictures, This study is to determine if intra refraction, and axial length on subjects vitreal ranibizumab is superior to laser A Trial of QPI-1007 Delivered by with retinopathy of prematurity and ablation therapy in the treatment of Single or Multi-Dose Intravitreal without retinopathy of prematurity. retinopathy of prematurity (ROP). The Injection(s) to Subjects with Acute Investigators: Irena Tsui, MD, Stacy study will assess the ability of these Nonarteritic Anterior Ischemic L. Pineles, MD, and Federico G. treatments to lead to regression of Optic Neuropathy (NAION) Velez, MD active ROP and prevent the develop This research study tests whether the ment of ocular complications that are experimental drug QPI-1007 helps Repeated Doses of an associated with poor visual outcome. prevent loss of visual acuity. QPI‑1007 Investigational Drug in Patients Investigator: Irena Tsui, MD is being developed to treat vision with Neovascular Age-Related loss that can occur when there is not Macular Degeneration enough blood flow to the nerve tissue This phase 2, year-long study requires in the eye, such as after a stroke the recruitment of patients with wet of the optic nerve or from NAION. or neovascular age-related macular Investigators: Peter A. Quiros, MD, degeneration who are naive to anti- Gad Heilweil, MD, Michael S. Ip, MD, VEGF treatment. Investigators: David Mohammad Khan, MD, Alfredo A Sarraf, MD, Michael B. Gorin, MD, Sadun, MD, PhD PhD, and Colin A. McCannel, MD

130 Stein Eye Institute | Appendices Appendices | Stein Eye Institute 130 Clinical Research Studies Appendices

Evaluating the Efficacy of a Ocular Melanoma Clinical Presentation and Single Intravitreal Injection for Management of Orbital Patients with Leber Hereditary Evaluating the Safety and Efficacy Plasmacytoma of Light-Activated AU-011 for the Optic Neuropathy Orbital plasmacytoma is a rare mono Treatment of Subjects with This clinical trial is to assess the effec clonal proliferation of plasma cells Small to Medium Primary tiveness of a gene therapy in improv that can be associated with multiple Choroidal Melanoma ing the visual outcome in patients with myeloma. The purpose of this study Leber Hereditary Optic Neuropathy Primary objectives are to evaluate is to contribute to the largest case (LHON) due to a mitochondrial muta the safety of intravitreal administra series of orbital plasmacytomas to tion. Investigator: Alfredo A. Sadun, tion of one of three dose levels and date and review its clinical characteris MD, PhD repeat dose regimens of light-activated tics. Investigator: Daniel B. Rootman, AU-011 and one or two laser applica MD, MS Evaluation of a Drug for the tions in the treatment of subjects with Treatment of Leber Hereditary small to medium primary choroidal Effect of External Eyelid Weighting Optic Neuropathy melanoma. Secondary objectives on Lid Position in Normal and include evaluating the immunogenicity Ptosis Patients This study evaluates the safety, and effectiveness of AU-011. Investi tolerability, and efficacy of a topical gators: Tara A. McCannel, MD, PhD, This investigation compares the ophthalmic solution in the treatment of Colin McCannel, MD, and Melissa ability of normal and ptotic patients subjects with Leber Hereditary Optic Chun, OD to maintain eyelid position by adapt Neuropathy (LHON). The study drug ing to acute and dramatic changes has been shown to enhance or benefit in protracting forces by using eyelid Molecular and Cytogenetic Studies mitochondria function in studies done weights. This project will help eluci of Ocular Melanoma on cells grown in the laboratory. Inves date the physiology of the eyelid posi tigator: Alfredo A. Sadun, MD, PhD This research is to study ocular mela tion maintenance system, and provide noma tumor tissue and to identify key insight into its ability to respond to Natural History Study of molecular and genetic features that changes in disease. Investigator: Leber Hereditary Optic Neuropathy could help predict those patients who Daniel B. Rootman, MD, MS may be at high risk for metastasis. Leber hereditary optic neuropathy Investigators: Lynn K. Gordon, MD, (LHON) is one of the diseases where Hyaluronic Acid Gels for PhD, Tara A. McCannel, MD, PhD, and Upper Lid Retraction in the mitochondria of the retina cells are Bradley R. Straatsma, MD, JD not functioning correctly, which can Active State Thyroid Eye Disease lead to loss of vision. This study is to This study is to determine if hyal PET/CT Imaging for Early obtain electroretinography (ERG) data uronic acid gel (HAG) can be used Detection of Ocular Melanoma and optical coherence tomography to correct upper eyelid retraction, (OCT) data from patients who carry This research involves the use of improve dry eye related symptoms, the Leber hereditary optic neuropathy combined positron emission tomog aesthetic appearance, and quality of gene. Investigator: Alfredo A. Sadun, raphy (PET)/computed tomography life in active-stage thyroid eye disease MD, PhD (CT) scans in subjects with ocular (TED). The study also aims to deter melanoma to ideally develop better mine the long-term outcome of TED Noninvasive Methods for Early ways of monitoring for tumor spread and how long the effects of HAG can Detection of Alzheimer Disease and allow for early treatment if metas last. Investigator: Daniel B. Rootman, tasis is found. Investigators: Tara A. MD, MS The purpose of this study is to obtain McCannel, MD, PhD, and Bradley R. electroretinography data and optical Straatsma, MD, JD coherence tomography data from Neuroendocrine Tumor Metastases patients with Alzheimer disease, with in the Eye and Orbit the aim of permitting earlier interven Orbital and Ophthalmic The purpose of this study is to under tion and improved disease monitoring. Plastic Surgery stand the diversity in presentation of Investigator: Alfredo Sadun MD, PhD carcinoid tumors of the orbit, as well Characteristics of the Brow–Eyelid as to identify, stage, and grade related Margin Relationship factors that may affect prognosis and The study purpose is to determine if thus treatment decisions. Also consid changing the effect of gravity has an ered will be if there are features of car effect on eyelid position. Investigators: cinoid tumor presentations in the orbit Robert Alan Goldberg, MD, and Daniel that can predict outcome and thus B. Rootman, MD, MS guide therapeutic decision-making. Investigator: Daniel B. Rootman, MD, MS

131 Stein Eye Institute | Appendices Appendices | Stein Eye Institute 131 Appendices Clinical Research Studies

Ocular Protrusion in Sitting and Pediatrics and Strabismus Genetic and Anatomic Studies of Supine Positions Eye Movement Disorders A Prospective Observation Study The aim of this study is to compare This study is conducting magnetic of Adult Strabismus the degree of ocular protrusion in resonance imaging of the extraocu normal individuals and patients with This study is to learn about treatments lar muscles. This procedure clarifies thyroid eye disease between sitting for strabismus in adults. There are the phenotypes and mechanisms of and lying (supine) positions. Investiga several different treatment options for congenital cranial dysinnervation syn tors: Robert Alan Goldberg, MD, and strabismus: sometimes these condi dromes whose hereditary properties Daniel B. Rootman, MD, MS tions are treated with special glasses have been characterized using modern that help to align the eyes (prism) molecular genetics. Patients with Pro-Inflammatory Cytokines, or with exercises that help the eyes these syndromes have severe forms Dry Eye, and Thyroid Eye Disease work together, and sometimes these of strabismus. Investigator: Joseph L. conditions are treated with surgery or Demer, MD, PhD This study is to determine whether Botox injection to straighten the eyes. there are specific inflammatory pro Investigators: Stacy L. Pineles, MD, Observational Study of Patients teins in tears of patients with active- and Federico G. Velez, MD stage thyroid eye disease (TED). If Diagnosed with Idiopathic these inflammatory proteins exist, the Bilateral Cataracts Biomechanical Analysis in study aims to determine whether they The purpose of this study is to under Strabismus Surgery can be used to predict dry eye symp stand better how many people who tomatology and TED activity. Investi This study aims to develop new have been diagnosed with early-onset gators: Robert Alan Goldberg, MD, and diagnostic tests and computer models idiopathic bilateral cataracts may have Daniel B. Rootman, MD, MS that will lead to improvements in a rare but treatable disease called strabismus surgery. Tests of binocular cerebrotendinous xanthomatosis Ptosis Surgery Outcomes Scale alignment and eye movements, as (CTX). Often one of the first signs of well as magnetic resonance imaging CTX is cataracts from an unknown This investigation is to define and of the extraocular muscles, are being validate a universal measure for ptosis cause at an early age. Investiga performed in the Institute’s Clinical tors: Federico G. Velez, MD, Stacy L. outcomes that can be used in defining and Basic Science Ocular Motility both value and efficacy in ptosis sur Pineles, MD, and Joseph L. Demer, Laboratory before and after strabis MD, PhD gery. Investigator: Daniel B. Rootman, mus surgery. To date, this research MD, MS has fundamentally contributed to the Optic Nerve in Amblyopia knowledge of the functional anatomy Studies on Tissue in of the extraocular muscles and con Amblyopia is a major cause of child Autoimmune Diseases nective tissues, and allowed discovery hood visual loss. This study uses high This study aims to determine the of causes of common strabismus and resolution, surface-coil magnetic reso cause of eye problems in Graves dis development of new types of surger nance imaging to study optic nerve ease and other autoimmune diseases. ies. Investigator: Joseph L. Demer, size in amblyopia. It tests the theory Examination is being done of material MD, PhD that the optic nerve is smaller than removed from orbits during surgical normal in amblyopia and that optic nerve size may be a limiting factor therapy for Graves disease or other Determining the Proportion in restoration of vision by amblyopia problems requiring surgery on the of Patients with Isolated treatment. Investigator: Joseph L. tissue surrounding the eyes, of thyroid Third, Fourth, and Sixth Nerve Demer, MD, PhD tissue removed during the course of Palsies of Microvascular Versus surgical therapy, or of blood drawn for Nonmicrovascular Etiology laboratory tests. Investigator: Robert Optical Coherence Tomography Magnetic resonance imaging scan in the Newborn Eye Alan Goldberg, MD ning is currently only recommended in atypical cases (ie, young age, no This study is to better characterize the Temporal Fossa in vascular risk factors). This study is to retina and optic nerve in newborns Different Ethnicities determine whether central nervous using spectral-domain optical coher The aim of this study is to investigate system abnormalities are detected ence tomography (SD-OCT). SD-OCT differences in anatomy of temporal in patients who otherwise would not has been used for many years to help fossa between different ethnicities have neuroimaging. Investigator: Stacy diagnose and treat adults with eye dis using three-dimensional CT scan L. Pineles, MD eases, but it has never been studied in images. Better knowledge of these newborns, where it could potentially differences is important for cosmetic help in the diagnoses of glaucoma, procedures to achieve better results optic nerve hypoplasia, foveal hypo and fewer complications. Investiga plasia, and colobomata, among many tors: Robert Alan Goldberg, MD, and other disorders. Investigator: Sherwin Catherine J. Hwang, MD J. Isenberg, MD

132 Stein Eye Institute | Appendices Appendices | Stein Eye Institute 132 Clinical Research Studies Appendices

Pediatric Cataract Surgery Sweep Visual Evoked Potential Outcomes Registry for Use in Amblyopia and The study aim is to collect core clinical Pediatric Optic Nerve Disorders data on children and teens undergoing Using a new technique, investiga surgery for cataracts in order to con tors are measuring vision in preverbal duct analyses and generate hypoth children to diagnose and follow optic eses. Clinical outcomes data will be nerve diseases. Currently, treat collected from affected subjects after ment decisions are based on clinical cataract surgery has been performed. examinations that are insensitive and Investigators: Stacy L. Pineles, MD, reveal vision loss well after permanent and Federico G. Velez, MD damage has taken place. This tech nique allows more accurate exami Prevention of Visual Impairment nations, which leads to provision of in School-Age Children treatments at the first signs of vision To promote the use of eyeglasses loss and thereby decreases the risk in schools, first- and second-grade of permanent damage. Investigators: students with refractive errors receive Joseph L. Demer, MD, PhD, Sherwin two pairs of eyeglasses, with one pair J. Isenberg, MD, Stacy L. Pineles, MD, staying at home and the other in the and Federico G. Velez, MD classroom. School nurses collaborate with teachers in monitoring the use of Study of Luminopia One eyeglasses in the classroom, and par Digital Therapeutic as ents receive eye care education. Inves Amblyopia Treatment tigator: Anne L. Coleman, MD, PhD The primary objective of this study is to establish safety and efficacy of the Sensory Processing and Learning Luminopia One therapeutic for the This study evaluates amblyopic treatment of amblyopia. Investigators: patients, who are traditionally thought Joseph L. Demer, MD, PhD, Simon to be beyond the critical period for Fung, MD, and Stacy L. Pineles, MD treatment. These subjects will be enrolled and randomized to one of the two amblyopia therapies using a per ceptual learning technique. Investiga tor: Stacy L. Pineles, MD

133 Stein Eye Institute | Appendices Appendices | Stein Eye Institute 133 Appendices

134 Stein Eye Institute | Appendices Appendices 2017–2018 Publications of the Full-Time Faculty

n the 2017–2018 academic year, Govetto A, Su D, Farajzadeh M, Gu L, Bok D, Yu F, Caprioli J, Piri N. IUCLA Department of Ophthalmol Megerdichian A, Platner E, Ducournau Downregulation of splicing regulator Y, Virgili G, Hubschman JP. Micro RBFOX1 compromises visual depth per ogy full-time faculty advanced vision- cystoid Macular Changes in Association ception. PLoS One. 2018 Jul 12;13(7): science research with 275 publica With Idiopathic Epiretinal Membranes in e0200417. Eyes With and Without Glaucoma: Clini tions that include peer-reviewed Moghimi S, Mazloumi M, Johari MK, articles, book chapters, and books. cal Insights. Am J Ophthalmol. 2017 Sep;181:156–165. Epub 2017 Jul 1. Fard MA, Chen R, Weinreb R, Nouri-Mahdavi K. Comparison of Schönbach EM, Wolfson Y, Strauss RW, macular choroidal thickness in patients July 2017 Ibrahim MA, Kong X, Muñoz B, Birch with pseudoexfoliation syndrome to Schwartz SD, Nagiel A, Lanza R. DG, Cideciyan AV, Hahn GA, Nittala M, normal control subjects with enhanced Cellular Therapies for Retina Disease: Sunness JS, Sadda SR, West SK, depth SD-OCT imaging. J Curr Ophthal A Strategic Approach. Springer Interna Scholl HPN; ProgStar Study Group. mol. 2017 Jul 12;29(4):258–263. tional Publishing. 2017. Macular Sensitivity Measured With Microperimetry in Stargardt Disease in Kuan EC, Tajudeen BA, Welch KC, Apinyawasisuk S, McCannel T, the Progression of Atrophy Secondary Chandra RK, Glasgow BJ, Suh JD. Arnold AC. Clinical and Spectral- to Stargardt Disease (ProgStar) Study: Aggressive necrotizing pseudomonal Domain Optical Coherence Tomography Report No. 7. JAMA Ophthalmol. 2017 sinonasal infections. Int Forum Allergy Appearance of Optic Disc Melano Jul 1;135(7):696–703. Rhinol. 2017 Sep;7(9):910–915. Epub cytoma: A New Classification and Dif 2017 Jul 14. ferentiation from Pigmented Choroidal Morshedian A, Toomey MB, Pollock GE, Frederiksen R, Enright JM, McCormick Chung LK, Bhatt NS, Lagman C, Lesions. Ocul Oncol Pathol. 2017 Jul; Pelargos PE, Qin Y, Gordon LK, 3(2):142–148. SD, Cornwall MC, Fain GL, Corbo JC. Cambrian origin of the CYP27C1- Wadehra M, Yang I. Epithelial mem Golan S, Gupta A, Goldberg RA. brane protein 2: Molecular inter mediated vitamin A1-to-A2 switch, a Double Vision After Minimally Invasive key mechanism of vertebrate sensory actions and clinical implications. J Clin Orbital Decompression. J Craniofac plasticity. R Soc Open Sci. 2017 Jul 5; Neurosci. 2017 Oct;44:84–88. Epub Surg. 2017 Jul;28(5):e412–e415. 4(7):170362. 2017 Jul 15. Review. Goldberg RA. Discussion: Vertical Yang J, Milasta S, Hu D, AlTahan AM, Martemyanov KA, Sampath AP. The Midface Lifting with Periorbital Anchor Interiano RB, Zhou J, Davidson J, Low Transduction Cascade in Retinal ing in the Management of Lower Eyelid J, Lin W, Bao J, Goh P, Nathwani AC, ON-Bipolar Cells: Signal Processing and Retraction: A 10-Year Clinical Retrospec Wang R, Wang Y, Ong SS, Boyd VA, Disease. Annu Rev Vis Sci. 2017 Sep tive Study. Plast Reconstr Surg. 2017 Young B, Das S, Shelat A, Wu Y, Li Z, 15;3:25–51. Epub 2017 Jul 17. Review. Jul;140(1):46–48. Zheng JJ, Mishra A, Cheng Y, Qu C, Alfreihi SH, Pineles SL, McCannel TA, Hariri AH, Velaga SB, Girach A, Ip MS, Peng J, Green DR, White S, Guy RK, Prada AM, Velez FG. Surgical manage Le PV, Lam BL, Fischer MD, Sankila Chen T, Davidoff AM. Targeting Histone ment of strabismus following choroi EM, Pennesi ME, Holz FG, MacLaren Demethylases in MYC-Driven Neuro dal melanoma plaque brachytherapy. RE, Birch DG, Hoyng CB, MacDonald blastomas with Ciclopirox. Cancer Res. J AAPOS. 2017 Aug;21(4):286–290.e2. IM, Black GC, Tsang SH, Bressler NM, 2017 Sep 1;77(17):4626–4638. Epub Epub 2017 Jul 18. 2017 Jul 6. Larsen M, Gorin MB, Webster AR, Chang MY, Velez FG, Demer JL, Sadda SR; Natural History of the Cook PJ, Thomas R, Kannan R, Bonelli L, Quiros PA, Arnold AC, Progression of Choroideremia (NIGHT) de Leon ES, Drilon A, Rosenblum MK, Sadun AA, Pineles SL. Accuracy of Study Group. Measurement and Scaltriti M, Benezra R, Ventura A. Diagnostic Imaging Modalities for Clas Reproducibility of Preserved Ellipsoid Somatic chromosomal engineering sifying Pediatric Eyes as Papilledema Zone Area and Preserved Retinal identifies BCAN-NTRK1 as a potent Versus Pseudopapilledema. Ophthal Pigment Epithelium Area in Eyes With glioma driver and therapeutic target. mology. 2017 Dec;124(12):1839–1848. Choroideremia. Am J Ophthalmol. 2017 Nat Commun. 2017 Jul 11;8:15987. Epub 2017 Jul 18. Jul;179:110–117. Junk AK, Chen PP, Lin SC, Nouri- Ghasemi Falavarjani K, Tsui I, Nagiel A, McCannel CA, Moreno C, Mahdavi K, Radhakrishnan S, Singh K, Sadda SR. Ultra-wide-field imaging in McCannel TA. Vitrectomy-assisted Chen TC. Disinfection of Tonometers: diabetic retinopathy. Vision Res. 2017 biopsy for molecular prognostication A Report by the American Academy of Oct;139:187–190. Epub 2017 Jul 20. of choroidal melanoma 2 mm or less Ophthalmology. Ophthalmology. 2017 Review. in thickness with a 27-gauge cutter. Dec;124(12):1867–1875. Epub 2017 Retina. 2017 Jul;37(7):1377–1382. Jul 11. Review. Jones L, Downie LE, Korb D, Benitez-Del-Castillo JM, Dana R, Lin TY, Li N, Yeh MW, Leung AM, Deng, SX, Dong PN, Geerling G, Hida Rootman DB. Prognostic indicators RY, Liu Y, Seo KY, Tauber J, Wakamatsu for the development of strabismus TH, Xu J, Wolffsohn JS, Craig JP. TFOS among patients with Graves’ ophthal DEWS II Management and Therapy mopathy. J Clin Transl Endocrinol. 2017 Report. Ocul Surf. 2017 Jul;15(3):575– Jul 11;9:38–40. 628. Epub 2017 Jul 20. Review.

Appendices | Stein Eye Institute 135 Publications

Zhao Z, Liang Y, Liu Y, Xu P, Flamme- Daneshvar R, Nouri-Mahdavi K. Wykoff CC, Ou WC, Croft DE, Payne Wiese MJ, Sun D, Sun J, Mullins RF, Optical Coherence Tomography Angi JF, Brown DM, Clark WL, Abdelfattah Chen Y, Cai J. Choroidal γδ T cells ography: A New Tool in Glaucoma Diag NS, Sadda SR; TREX-AMD Study in protection against retinal pigment nostics and Research. J Ophthalmic Vis Group. Neovascular age-related macular epithelium and retinal injury. FASEB J. Res. 2017 Jul–Sep;12(3):325–332. degeneration management in the third 2017 Nov;31(11):4903–4916. Epub year: final results from the TREX-AMD 2017 Jul 20. August 2017 randomised trial. Br J Ophthalmol. 2018 Apr;102(4):460–464. Epub 2017 Aug 4. Hosseini HR, Kaklamanos EG, Huang P, Tepelus T, Vickers LA, Athanasiou AE. Treatment outcomes Baghdasaryan E, Huang J, Irvine JA, Huang J, Maram J, Tepelus TC, Modak of pre-surgical infant orthopedics in Hsu HY, Sadda S, Lee OL. Quantita C, Marion K, Sadda SR, Chopra V, patients with non-syndromic cleft lip tive Analysis of Depth, Distribution, Lee OL. Comparison of manual & and/or palate: A systematic review and Density of Cysts in Acanthamoeba automated analysis methods for corneal and meta-analysis of randomized con Keratitis Using Confocal Microscopy. endothelial cell density measurements trolled trials. PLoS One. 2017 Jul 24; Cornea. 2017 Aug;36(8):927–932. by specular microscopy. J Optom. 2017 12(7):e0181768. Tan ACS, Yzer S, Freund KB, Dansingani Aug 7. Minasyan L, Sreekumar PG, Hinton DR, KK, Phasukkijwatana N, Sarraf D. Cho Akil H, Chopra V, Al-Sheikh M, Kannan R. Protective Mechanisms roidal changes associated with serous Ghasemi Falavarjani K, Huang AS, of the Mitochondrial-Derived Peptide macular detachment in eyes with Sadda SR, Francis BA. Swept-source Humanin in Oxidative and Endoplasmic staphyloma, dome-shaped macula or OCT angiography imaging of the macu Reticulum Stress in RPE Cells. Oxid tilted disk syndrome. Retina. 2017 Aug; lar capillary network in glaucoma. Br J Med Cell Longev. 2017;2017:1675230. 37(8):1544–1554. Ophthalmol. 2017 Aug 9. Epub 2017 Jul 26. Review. Tepelus TC, Huang J, Sadda SR, Rajabi MT, Papageorgiou K, Taban M, Zhou XE, He Y, de Waal PW, Gao X, Lee OL. Characterization of Corneal Hwang CJ, Hosseini SS, Rajabi MB, Kang Y, Van Eps N, Yin Y, Pal K, Involvement in Eyes With Mucous Goldberg RA. Ultrasonographic motion Goswami D, White TA, Barty A, Membrane Pemphigoid by In Vivo analysis of lower eyelid compartments Latorraca NR, Chapman HN, Hubbell Confocal Microscopy. Cornea. 2017 in patients with chronic thyroid associ WL, Dror RO, Stevens RC, Cherezov V, Aug;36(8):933–941. ated ophthalmopathy. J Curr Ophthal Gurevich VV, Griffin PR, Ernst OP, Al-Sheikh M, Falavarjani KG, Pfau M, mol. 2017 Aug 10;29(4):310–317. Melcher K, Xu HE. Identification of Uji A, Le PP, Sadda SR. Quantitative Williams DS, Pijpers IAB, Ridolfo R, Phosphorylation Codes for Arrestin Features of the Choriocapillaris in Recruitment by G Protein-Coupled van Hest JCM. Controlling the morphol Healthy Individuals Using Swept-Source ogy of copolymeric vectors for next Receptors. Cell. 2017 Jul 27;170(3): Optical Coherence Tomography Angiog 457–469.e13. generation nanomedicine. J Control raphy. Ophthalmic Surg Lasers Imaging Release. 2017 Aug 10;259:29–39. Tseng VL, Coleman AL, Chang MY, Retina. 2017 Aug 1;48(8):623–631. Review. Caprioli J. Aqueous shunts for glau Böni C, Thorne JE, Spaide RF, Fung SSM, Jabbour S, Harissi-Dagher coma. Cochrane Database Syst Rev. Ostheimer TA, Sarraf D, Levinson 2017 Jul 28;7:CD004918. Review. M, Tan RRG, Hamel P, Baig K, Ali A. RD, Goldstein DA, Rifkin LM, Vitale Visual Outcomes and Complications Friedman DI, Quiros PA, Subramanian AT, Jaffe GJ, Holland GN. Fundus of Type I Boston Keratoprosthesis in PS, Mejico LJ, Gao S, McDermott M, Autofluorescence Findings in Eyes Children: A Retrospective Multicenter Wall M; and the NORDIC IIHTT Study With Birdshot Chorioretinitis. Invest Study and Literature Review. Ophthal Group. Headache in Idiopathic Intra Ophthalmol Vis Sci. 2017 Aug 1;58(10): mology. 2018 Feb;125(2):153–160. cranial Hypertension: Findings From 4015–4025. Epub 2017 Aug 12. the Idiopathic Intracranial Hyperten Demer JL, Clark RA, Suh SY, Giaconi sion Treatment Trial. Headache. 2017 McCannel CA. Continuous Curvilinear JA, Nouri-Mahdavi K, Law SK, Capsulorhexis Training and Non-Rhexis Sep;57(8):1195–1205. Epub 2017 Bonelli L, Coleman AL, Caprioli J. Jul 28. Related Vitreous Loss: The Specific Magnetic Resonance Imaging of Optic ity of Virtual Reality Simulator Surgical Wilson JT, Gerber MJ, Prince SW, Chen Nerve Traction During Adduction in Training (An American Ophthalmological CW, Schwartz SD, Hubschman JP, Primary Open-Angle Glaucoma With Society Thesis). Trans Am Ophthalmol Tsao TC. Intraocular robotic interven Normal Intraocular Pressure. Invest Soc. 2017 Aug 22;115:T2. tional surgical system (IRISS): Mechani Ophthalmol Vis Sci. 2017 Aug 1;58(10): cal design, evaluation, and master-slave 4114–4125. Akil H, Al-Sheikh M, Falavarjani KG, Francis B, Chopra V. Choroidal thick manipulation. Int J Med Robot. 2018 Garrity ST, Holz EJ, Sarraf D. Amalric Feb;14(1). Epub 2017 Jul 31. ness and structural glaucoma param Triangular Syndrome Associated With eters in glaucomatous, preperimetric Rootman DB, Golan S, Pavlovich P, Outer Nuclear Layer Infarction. Ophthal glaucomatous, and healthy eyes using Rootman J. Postoperative Changes in mic Surg Lasers Imaging Retina. 2017 swept-source OCT. Eur J Ophthalmol. Strabismus, Ductions, Exophthalmom Aug 1;48(8):668–670. 2017 Aug 30;27(5):548–554. etry, and Eyelid Retraction After Orbital Sharifipour F, Morales E, Lee JW, Decompression for Thyroid Orbitopathy. Giaconi J, Afifi AA, Yu F,Caprioli J, Ophthalmic Plast Reconstr Surg. 2017 Nouri-Mahdavi K. Vertical Macular Jul/Aug;33(4):289–293. Asymmetry Measures Derived From SD-OCT for Detection of Early Glau coma. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4310–4317.

136 Stein Eye Institute | Appendices Publications

Balducci N, Morara M, Veronese C, Saldanha IJ, Lindsley K, Do DV, Chuck Halai UA, Nielsen-Saines K, Moreira ML, Barboni P, Casadei NL, Savini G, RS, Meyerle C, Jones LS, Coleman de Sequeira PC, Junior JPP, de Araujo Parisi V, Sadun AA, Ciardella A. Optical AL, Jampel HD, Dickersin K, Virgili G. Zin A, Cherry J, Gabaglia CR, Gaw SL, coherence tomography angiography in Comparison of Clinical Trial and System Adachi K, Tsui I, Pilotto JH, Nogueira acute arteritic and non-arteritic anterior atic Review Outcomes for the 4 Most RR, de Filippis AMB, Brasil P. Maternal ischemic optic neuropathy. Graefes Prevalent Eye Diseases. JAMA Ophthal Zika Virus Disease Severity, Virus Load, Arch Clin Exp Ophthalmol. 2017 Nov; mol. 2017 Sep 1;135(9):933–940. Prior Dengue Antibodies, and Their 255(11):2255–2261. Epub 2017 Aug 31. Relationship to Birth Outcomes. Clin Zin AA, Tsui I, Rossetto J, Vasconcelos Infect Dis. 2017 Sep 15;65(6):877–883. Zhang C, Miller DJ, Guibao CD, Donato Z, Adachi K, Valderramos S, Halai UA, DM, Hanks SK, Zheng JJ. Structural Pone MVDS, Pone SM, Silveira Filho Qin Y, Chan AM, Chang YL, Matynia A, and functional insights into the interac JCB, Aibe MS, da Costa ACC, Zin OA, Kouris NA, Kimbrel EA, Ashki N, Parikh tion between the Cas family scaffolding Belfort R Jr, Brasil P, Nielsen-Saines K, S, Gorin MB, Lanza R, Levinson RD, protein p130Cas and the focal adhesion- Moreira MEL. Screening Criteria for Gordon LK. Human Embryonic Stem associated protein paxillin. J Biol Chem. Ophthalmic Manifestations of Congeni Cell-Derived Mesenchymal Stromal 2017 Nov 3;292(44):18281–18289. tal Zika Virus Infection. JAMA Pediatr. Cells Decrease the Development of Epub 2017 Aug 31. 2017 Sep 1;171(9):847–854. Severe Experimental Autoimmune Uveitis in B10.RIII Mice. Ocul Immunol Tepelus TC, Chiu GB, Maram J, September 2017 (Fall) Inflamm. 2017 Sep 15:1–9. Huang J, Chopra V, Sadda SR, Lee Kally PM, Sidikaro Y, McCannel CA. OL. Corneal features in ocular graft- Cascavilla ML, Parisi V, Triolo G, Ziccardi Resolution of treatment-resistant versus-host disease by in vivo confocal L, Borrelli E, Di Renzo A, Balducci N, subretinal fluid in a patient with exuda microscopy. Graefes Arch Clin Exp Oph Lamperti C, Bianchi Marzoli S, Darvizeh tive age-related macular degeneration thalmol. 2017 Dec;255(12):2389–2397. F, Sadun AA, Carelli V, Bandello F, following endophthalmitis. Retin Cases Epub 2017 Sep 5. Barboni P. Retinal dysfunction char Brief Rep. 2017 Fall;11(4):316–318. acterizes subtypes of dominant optic Galloway CA, Dalvi S, Hung SSC, Apinyawasisuk S, Zhou X, Tian JJ, atrophy. Acta Ophthalmol. 2018 Mar; MacDonald LA, Latchney LR, Wong 96(2):e156–e163. Epub 2017 Sep 19. Garcia GA, Karanjia R, Sadun AA. RCB, Guymer RH, Mackey DA, Validity of Forced Eyelid Closure Test: A Williams DS, Chung MM, Gamm DM, Wang K, Jayadev C, Nittala MG, Velaga Novel Clinical Screening Test for Ocular Pébay A, Hewitt AW, Singh R. Drusen SB, Ramachandra CA, Bhaskaranand Myasthenia Gravis. J Neuroophthalmol. in patient-derived hiPSC-RPE models M, Bhat S, Solanki K, Sadda SR. Auto 2017 Sep;37(3):253–257. of macular dystrophies. Proc Natl Acad mated detection of diabetic retinopathy Arnold AC. Does Nocturnal Hypoten Sci USA. 2017 Sep 26;114(39):E8214– lesions on ultrawidefield pseudocolour sion Play a Causal Role in Nonarteritic E8223. Epub 2017 Sep 6. images. Acta Ophthalmol. 2018 Mar; 96(2):e168–e173. Epub 2017 Sep 19. Anterior Ischemic Optic Neuropathy?: Chung LK, Pelargos PE, Chan AM, Response. J Neuroophthalmol. 2017 Demos JV, Lagman C, Sheppard JP, Borrelli E, Lei J, Balasubramanian S, Sep;37(3):352–353. Nguyen T, Chang YL, Hojat SA, Prins Uji A, Cozzi M, Sarao V, Lanzetta P, Borrelli E, Abdelfattah NS, Uji A, Nittala RM, Liau LM, Nghiemphu L, Lai A, Staurenghi G, Sadda SR. Green emis MG, Boyer DS, Sadda SR. Postrecep Cloughesy TF, Yong WH, Gordon LK, sion fluorophores in eyes with atrophic tor Neuronal Loss in Intermediate Wadehra M, Yang I. Tissue micro age-related macular degeneration: a Age-related Macular Degeneration. array analysis for epithelial membrane colour fundus autofluorescence pilot Am J Ophthalmol. 2017 Sep;181:1–11. protein-2 as a novel biomarker for study. Br J Ophthalmol. 2018 Jun; gliomas. Brain Tumor Pathol. 2018 Jan; 102(6):827–832. Epub 2017 Sep 25. Tu JH, Foote KG, Lujan BJ, Ratnam K, 35(1):1–9. Epub 2017 Sep 8. Qin J, Gorin MB, Cunningham ET Jr, Tan CS, Sadda SR. Anti-vascular Tuten WS, Duncan JL, Roorda A. Dys Sinha KR, Duckwiler G, Rootman DB. endothelial growth factor therapy for flective cones: Visual function and cone Urticarial reaction following endovas the treatment of myopic choroidal neo reflectivity in long-term follow-up of cular embolization of an orbital arterio vascularization. Clin Ophthalmol. 2017 acute bilateral foveolitis. Am J Ophthal venous malformation (AVM) with Sep 26;11:1741–1746. mol Case Rep. 2017 Sep;7:14–19. n-butyl cyanoacrylate (nBCA) glue. Interv Neuroradiol. 2017 Dec;23(6):666– Zhang X, Dastiridou A, Francis BA, Amini N, Daneshvar R, Sharifipour F, 668. Epub 2017 Sep 11. Tan O, Varma R, Greenfield DS, Romero P, Henry S, Caprioli J, Schuman JS, Huang D; Advanced Nouri-Mahdavi K. Structure-Function Deng, SX, Lee WB, Hammersmith KM, Imaging for Glaucoma Study Group. Relationships in Perimetric Glaucoma: Kuo AN, Li JY, Shen JF, Weikert MP, Comparison of Glaucoma Progres Comparison of Minimum-Rim Width Shtein RM. 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October 2017 Lei J, Durbin MK, Shi Y, Uji A, Balasub Huang AS, Francis BA, Weinreb RN. Balasubramanian S, Lei J, Nittala MG, ramanian S, Baghdasaryan E, Al-Sheikh Structural and functional imaging of Velaga SB, Haines J, Pericak-Vance MA, M, Sadda SR. Repeatability and Repro aqueous humour outflow: a review. Clin Stambolian D, Sadda SR. Association ducibility of Superficial Macular Retinal Exp Ophthalmol. 2018 Mar;46(2):158– of drusen volume with choroidal param Vessel Density Measurements Using 168. Epub 2017 Oct 12. Review. Optical Coherence Tomography Angiog eters in nonneovascular age-related Zakharevich M, Kattan JM, Chen JL, macular degeneration. Retina. 2017 raphy En Face Images. JAMA Ophthal mol. 2017 Oct 1;135(10):1092–1098. Lin BR, Cervantes AE, Chung DD, Oct;37(10):1880–1887. Frausto RF, Aldave AJ. Elucidating the Cirineo N, Morales E, Lee JM, Lonngi M, Velez FG, Tsui I, Davila JP, molecular basis of PPCD: Effects of Ramanathan M, Hirunpatravong P, Rahimi M, Chan C, Sarraf D, Demer decreased ZEB1 expression on corneal Lin M, Capistrano V, Abdelmonen A, JL, Pineles SL. Spectral-Domain Optical endothelial cell function. Mol Vis. 2017 Yu F, Nouri-Mahdavi K, Coleman AL, Coherence Tomographic Angiography Oct 14;23:740–752. in Children With Amblyopia. JAMA Caprioli J. Expert Evaluation of Visual Pijpers IAB, Abdelmohsen LKEA, Field Decay in Glaucoma Correlates Ophthalmol. 2017 Oct 1;135(10): 1086–1091. Williams DS, van Hest JCM. Morphol With the Fast Component of Visual ogy Under Control: Engineering Bio Field Loss. J Glaucoma. 2017 Oct; Shin A, Yoo L, Park J, Demer JL. Finite degradable Stomatocytes. ACS Macro 26(10):902–910. Element Biomechanics of Optic Nerve Lett. 2017 Nov 21;6(11):1217–1222. Cunningham ET, Levinson RD, Sheath Traction in Adduction. J Bio Epub 2017 Oct 19. mech Eng. 2017 Oct 1;139(10). Denniston AK, Brézin AP, Zierhut M. Thorne AW, Chundury RV, Perry JD, Birdshot Chorioretinopathy. Ocul Immu Suh SY, Le A, Shin A, Park J, Demer JL. Rootman DB. Relationship between nol Inflamm. 2017 Oct;25(5):589–593. Progressive Deformation of the Optic ocular dominance and brow position Garrity ST, Paques M, Gaudric A, Nerve Head and Peripapillary Struc in patients with blepharoptosis. Orbit. Freund KB, Sarraf D. Considerations in tures by Graded Horizontal Duction. 2018 Apr;37(2):145–148. Epub 2017 the Understanding of Venous Outflow Invest Ophthalmol Vis Sci. 2017 Oct 1; Oct 20. 58(12):5015–5021. in the Retinal Capillary Plexus. Retina. Golan S, Goldberg RA. Abducens 2017 Oct;37(10):1809–1812. Hazim RA, Karumbayaram S, Jiang M, nerve palsy after orbital decompression. Magalhaes OA, Aldave AJ. Scleral Dimashkie A, Lopes VS, Li D, Burgess Orbit. 2018 Jun;37(3):230–234. Epub Pneumatonometry in Penetrating Kera BL, Vijayaraj P, Alva-Ornelas JA, Zack 2017 Oct 23. JA, Kohn DB, Gomperts BN, Pyle AD, toplasty: A Clinical Study. Cornea. 2017 Scott IU, Figueroa MJ, Oden NL, Oct;36(10):1200–1205. Lowry WE, Williams DS. Differentia tion of RPE cells from integration-free Ip MS, Blodi BA, VanVeldhuisen PC; Carelli V, La Morgia C, Ross-Cisneros iPS cells and their cell biological char SCORE2 Investigator Group. SCORE2 FN, Sadun AA. Optic neuropathies: acterization. Stem Cell Res Ther. 2017 Report 5: Vision-Related Function in the tip of the neurodegeneration Oct 2;8(1):217. Patients With Macular Edema Second iceberg. Hum Mol Genet. 2017 Oct 1; ary to Central Retinal or Hemiretinal 26(R2):R139–R150. Review. Pichi F, Sarraf D, Morara M, Mazumdar Vein Occlusion. Am J Ophthalmol. 2017 S, Neri P, Gupta V. Pearls and pitfalls of Dec;184:147–156. Epub 2017 Oct 23. Chang MY, Phasukkijwatana N, Garrity optical coherence tomography angiog S, Pineles SL, Rahimi M, Sarraf D, raphy in the multimodal evaluation of Fung SSM, Brookes J, Wilkins MR, Johnston M, Charles A, Arnold AC. uveitis. J Ophthalmic Inflamm Infect. Adams GGW. Mobile femtosecond Foveal and Peripapillary Vascular 2017 Oct 5;7(1):20. Review. laser platform for pediatric cataract Decrement in Migraine With Aura surgery. Eur J Ophthalmol. 2018 Mar; Demonstrated by Optical Coherence Diouf B, Lin W, Goktug A, Grace CRR, 28(2):246–250. Epub 2017 Oct 26. Tomography Angiography. Invest Waddell MB, Bao J, Shao Y, Heath RJ, Zheng JJ, Shelat AA, Relling MV, Chen Govetto A, Bhavsar KV, Virgili G, Ophthalmol Vis Sci. 2017 Oct 1;58(12): Gerber MJ, Freund KB, Curcio CA, 5477–5484. T, Evans WE. Alteration of RNA Splicing by Small-Molecule Inhibitors of the Burgoyne CF, Hubschman JP, Sarraf Garrity ST, Iafe NA, Phasukkijwatana N, Interaction between NHP2L1 and U4. D. Tractional Abnormalities of the Chen X, Sarraf D. Quantitative Analy SLAS Discov. 2018 Feb;23(2):164–173. Central Foveal Bouquet in Epiretinal sis of Three Distinct Retinal Capillary Epub 2017 Oct 6. Membranes: Clinical Spectrum and Plexuses in Healthy Eyes Using Optical Pathophysiological Perspectives. Am J Coherence Tomography Angiography. McCannel TA, Kim E, Kamrava M, Ophthalmol. 2017 Dec;184:167–180. Invest Ophthalmol Vis Sci. 2017 Oct 1; Lamb J, Caprioli J, Yang D, McCannel Epub 2017 Oct 26. 58(12):5548–5555. CA. New ultra-wide-field angiographic grading scheme for radiation retinopa Newman NJ, Yu-Wai-Man P, Sadun AA, Garrity ST, Sarraf D. The Arc of Change thy after iodine-125 brachytherapy for Karanjia R, Carelli V. Management of in Optical Coherence Tomographic uveal melanoma. Retina. 2017 Oct 6. ophthalmologic manifestations of mito Angiography Technology: Progres chondrial diseases. Genet Med. 2017 sion Toward Greater Reliability. JAMA Mei H, González S, Nakatsu MN, Dec;19(12). Epub 2017 Oct 26. Baclagon ER, Chen FV, Deng, SX. Ophthalmol. 2017 Oct 1;135(10): Amini N, Alizadeh R, Parivisutt N, 1098–1099. Human adipose-derived stem cells support the growth of limbal stem/ Kim E, Nouri-Mahdavi K, Caprioli J. progenitor cells. PLoS One. 2017 Optic Disc Image Subtraction as an Aid Oct 11;12(10):e0186238. to Detect Glaucoma Progression. Transl Vis Sci Technol. 2017 Oct 27;6(5):14.

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Huang P, Huang J, Tepelus T, Maram Le Q, Xu J, Deng, SX. The diagnosis Sung S, Dabironezare S, Llombart N, J, Sadda S, Lee OL. Validity of a new of limbal stem cell deficiency. Ocul Selvin S, Bajwa N, Chantra S, Nowroozi comprehensive pterygia grading scale Surf. 2018 Jan;16(1):58–69. Epub 2017 B, Garritano J, Goell J, Li A, Deng, SX, for use in clinical research and clinical Nov 4. Review. Brown E, Grundfest WS, Taylor ZD. trial. Int Ophthalmol. 2017 Oct 27. Optical System Design for Noncontact, Cook JD, Ng SY, Lloyd M, Eddington S, Normal Incidence, THz Imaging of in Sacconi R, Freund KB, Yannuzzi LA, Sun H, Nathans J, Bok D, Radu RA, vivo Human Cornea. IEEE Trans Tera Dolz-Marco R, Souied E, Capuano V, Travis GH. Peropsin modulates transit hertz Sci Technol. 2018 Jan;8(1):1–12. Semoun O, Phasukkijwatana N, Sarraf of vitamin A from retina to retinal pig Epub 2017 Nov 22. D, Carnevali A, Querques L, Bandello F, ment epithelium. J Biol Chem. 2017 Querques G. The Expanded Spectrum Dec 29;292(52):21407–21416. Epub Lin SR, Miller KM. Lessons learned of Perifoveal Exudative Vascular Anoma 2017 Nov 6. from implantation of Morcher 50D and lous Complex. Am J Ophthalmol. 2017 96S artificial iris diaphragms. Case Rep Dec;184:137–146. Epub 2017 Oct 27. Elzarrug H, Miller KM, Yu F, Farzad S, Ophthalmol. 2017 Nov 23;8(3):527–534. Grusha YO. Effect of anterior capsule Straatsma BR, Spivey BE. American polishing on the need for laser capsul Chang MY, Coleman AL, Tseng VL, Journal of Ophthalmology 1993–2002: otomy. Open J Ophthalmol, 2017 Nov; Demer JL. Surgical interventions for A Decade of Change. Am J Ophthalmol. 7:319–331. vertical strabismus in superior oblique 2018 Jan;185:3–4. Epub 2017 Oct 31. palsy. Cochrane Database Syst Rev. available. Khan MA, Kuley A, Riemann CD, 2017 Nov 27;11:CD012447. Review. Berrocal MH, Lakhanpal RR, Hsu J, Sivalingam A, Ho AC, Regillo CD. Kerur N, Fukuda S, Banerjee D, Kim Y, November 2017 Long-Term Visual Outcomes and Safety Fu D, Apicella I, Varshney A, Yasuma Bozkurt TK, Acar B, Kilavuzoglu AE, Profile of 27-Gauge Pars Plana Vitrec R, Fowler BJ, Baghdasaryan E, Marion Akdemir MO, Hamilton DR, Cosar tomy for Posterior Segment Disease. KM, Huang X, Yasuma T, Hirano Y, Yurteri CB, Acar S. An 11-Year Review Ophthalmology. 2018 Mar;125(3):423– Serbulea V, Ambati M, Ambati VL, of Keratoplasty in a Tertiary Referral 431. Epub 2017 Nov 13. Kajiwara Y, Ambati K, Hirahara S, Center in Turkey: Changing Surgical Bastos-Carvalho A, Ogura Y, Terasaki H, Techniques for Similar Indications. Eye Balasubramanian S, Tepelus T, Stenger Oshika T, Kim KB, Hinton DR, Leitinger Contact Lens. 2017 Nov;43(6):364–370. MB, Lee SMC, Laurie SS, Liu JHK, N, Cambier JC, Buxbaum JD, Kenney Feiveson AH, Sadda SR, Huang AS, MC, Jazwinski SM, Nagai H, Hara I, Srinivas S, Tan O, Nittala MG, Wu JL, Macias BR. Thigh Cuffs as a Counter Fawzi AA, Huang D, Sadda SR. Assess West AP, Fitzgerald KA, Sadda SR, measure for Ocular Changes in Simu Gelfand BD, Ambati J. cGAS drives ment of retinal blood flow in diabetic lated Weightlessness. Ophthalmology. retinopathy using doppler fourier- noncanonical-inflammasome activation 2018 Mar;125(3):459–460. Epub 2017 in age-related macular degeneration. domain optical coherence tomography. Nov 16. Retina. 2017 Nov;37(11):2001–2007. Nat Med. 2018 Jan;24(1):50–61. Epub Ghasemi Falavarjani K, Al-Sheikh M, 2017 Nov 27. Tian JJ, Coupland S, Karanjia R, Sadun Darvizeh F, Sadun AA, Sadda SR. AA. Melanoma-Associated Retinopa Retinal vessel calibre measurements December 2017 (Winter) thy 28 Years After Diagnosis. JAMA by optical coherence tomography Akil H, Vu PQ, Nguyen AH, Nugent A, Ophthalmol. 2017 Nov 1;135(11): angiography. Br J Ophthalmol. 2017 Chopra V, Francis BA, Tan JC. Revers 1276–1277. Jul;101(7):989–992. Epub 2016 Nov 16. ible Venting Stitch for Fenestrating Valve-less Glaucoma Shunts. J Glau Tsui I, Chu A. Hot Topics in Retinopa Govetto A, Virgili G, Rodriguez FJ, coma. 2017 Dec;26(12):1081–1085. thy of Prematurity. Pediatr Ann. 2017 Figueroa MS, Sarraf D, Hubschman Nov 1;46(11):e415–e422. Review. JP. Functional and anatomical signifi Carelli V, Carbonelli M, de Coo IF, Uji A, Balasubramanian S, Lei J, cance of the ectopic inner foveal layers Kawasaki A, Klopstock T, Lagrèze WA, Baghdasaryan E, Al-Sheikh M, Sadda in eyes with idiopathic epiretinal mem La Morgia C, Newman NJ, Orssaud C, SR. Choriocapillaris Imaging Using branes: Surgical Results at 12 Months. Pott JWR, Sadun AA, van Everdingen Multiple En Face Optical Coherence Retina. 2017 Nov 16. J, Vignal-Clermont C, Votruba M, Yu-Wai-Man P, Barboni P. International Tomography Angiography Image Aver Bird AC, Bok D. Why the macula? Eye Consensus Statement on the Clinical aging. 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Schwartz SD, Sadda SR, Sarraf D, sus Definition for Atrophy Associated Diagnostic and Therapeutic Challenges. Tsui I. Optical coherence tomography Retina. 2017 Nov 22. with Age-Related Macular Degenera angiography of the fovea in children tion on OCT: Classification of Atrophy born preterm. Retina. 2017 Dec;37(12): Report 3. Ophthalmology. 2018 Apr; 2289–2294. 125(4):537–548. Epub 2017 Nov 2.

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Huang J, Liu X, Tepelus TC, Nazikyan Sung S, Selvin S, Bajwa N, Chantra S, Bergdoll LA, Lerch MT, Patrick JW, T, Chopra V, Sadda SR, Lee OL. Nowroozi B, Garritano J, Goell J, Li A, Belardo K, Altenbach C, Bisignano P, Comparison of the Center and Flex- Deng, SX, Brown E, Grundfest WS, Laganowsky A, Grabe M, Hubbell Center Methods of Corneal Endothelial Taylor ZD. THz imaging system for WL, Abramson J. Protonation state Cell Analysis in the Presence of Guttae. in vivo human cornea. IEEE Trans Tera of glutamate 73 regulates the forma Cornea. 2017 Dec;36(12):1514–1520. hertz Sci Technol. 2018 Jan;8(1):27–37. tion of a specific dimeric association Epub 2017 Dec 7. of mVDAC1. Proc Natl Acad Sci U S A. Klufas MA, Richter E, Itty S, Moreno C, 2018 Jan 9;115(2):E172–E179 Epub McCannel CA, McCannel TA. Compari Travis AM, Heflin SJ, Hirano AA, 2017 Dec 26. son of Gene Expression Profiling and Brecha NC, Arshavsky VY. 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Published by Heidelberg Engi Endothelial Cell Loss 3 Years After Suc Song Y, Sun M, Wang N, Zhou X, neering, Heidelberg, Germany. 2018. cessful Descemet Stripping Automated Zhao J, Wang Q, Chen S, Deng Y, Qiu L, Chen Y, Aldave AJ, Zhang F. Preva Khitri M, Isenberg SJ. International Endothelial Keratoplasty in the Cornea Pediatric Ophthalmology. In Rudolph’s Preservation Time Study: A Randomized lence of transforming growth factor β-induced gene corneal dystrophies in Pediatrics. 23nd ed. Rudolph CR, Clinical Trial. JAMA Ophthalmol. 2017 Rudolph AM, Lister GE, First LR, Dec 1;135(12):1394–1400. Chinese refractive surgery candidates. J Cataract Refract Surg. 2017 Dec; Gershon AA, eds. McGraw-Hill Medi Rosenwasser GO, Szczotka-Flynn LB, 43(12):1489–1494. Epub 2017 Dec 9. cal Publishing Division, New York, NY. Ayala AR, Liang W, Aldave AJ, Dunn 2018. Wu CM, Wu AM, Tseng VL, Yu F, SP, McCall T, Navarro LC, Pramanik S, Truong DT, Miller KM. Chapter 12. Iris Ross KW, Stulting RD, Terry MA, Tu EY, Coleman AL. Frequency of a diagnosis of glaucoma in individuals who con Reconstruction. In Agarwal A, ed. More Verdier DD, Kollman C, Gal RL, Beck Phaco Nightmares: Conquering Cataract RW, Lass JH; Cornea Preservation sume coffee, tea and/or soft drinks. Br J Ophthalmol. 2018 Aug;102(8): Catastrophes. Thorofare, NJ: SLACK Time Study Group. Effect of Cornea Inc., 2018. Preservation Time on Success of Des 1127–1133. Epub 2017 Dec 14. cemet Stripping Automated Endothelial Kashani AH, Green KM, Kwon J, Chu Z, Aravena C, Yu F, Aldave AJ. Long- Keratoplasty: A Randomized Clinical Zhang Q, Wang RK, Garrity S, Sarraf D, Term Visual Outcomes, Complications, Trial. JAMA Ophthalmol. 2017 Dec 1; Rebhun CB, Waheed NK, Schaal KB, and Retention of the Boston Type I 135(12):1401–1409. Munk MR, Gattoussi S, Freund KB, Keratoprosthesis. Cornea. 2018 Jan; 37(1):3–10. Fatehi N, Morales E, Parivisutt N, Zheng F, Liu G, Rosenfeld PJ. 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Hirano AA, Liu X, Brecha NC, Barnes S. Fan W, Abdelfattah NS, Uji A, Lei J, Dohlman CH, Cade F, Regatieri Analysis of Feedback Signaling from Ip M, Sadda SR, Wykoff CC; TREX- CV, Zhou C, Lei F, Crnej A, Harissi- Horizontal Cells to Photoreceptors AMD Study Group. Subfoveal choroidal Dagher M, Robert MC, Papaliodis GN, in Mice. Methods Mol Biol. 2018; thickness predicts macular atrophy Chen D, Aquavella JV, Akpek EK, 1753:179–189. in age-related macular degeneration: Aldave AJ, Sippel KC, D’Amico DJ, results from the TREX-AMD trial. Dohlman JG, Fagerholm P, Wang Liang D, Shao H, Born WK, O’Brien RL, Graefes Arch Clin Exp Ophthalmol. L, Shen LQ, González-Andrades M, Kaplan HJ, Sun D. Connection between 2018 Mar;256(3):511–518. Epub 2018 Chodosh J, Kenyon KR, Foster CS, γδ T-cell- and Adenosine-Mediated Jan 27. Pineda R, Melki S, Colby KA, Ciolino Immune Regulation in the Pathogenesis JB, Vavvas DG, Kinoshita S, Dana R, of Experimental Autoimmune Uveitis. Bakhoum MF, Wu WP, White EC, Paschalis EI. Chemical Burns of the Crit Rev Immunol. 2018;38(3):233–243. Sengillo JD, Sanfilippo C, Morcos MM, Eye: The Role of Retinal Injury and New Freund KB, Perry HD, Sarraf D, Tsang Volland S, Williams DS. Preservation of Therapeutic Possibilities. Cornea. 2018 SH. Mitochondrial A3243G mutation Feb;37(2):248–251. Photoreceptor Nanostructure for Elec results in corneal endothelial polymega tron Tomography Using Transcardiac thism. Graefes Arch Clin Exp Ophthal Dyk DW, Miller KM. Mechanical model Perfusion Followed by High-Pressure mol. 2018 Mar;256(3):583–588. Epub of human eye compliance for volumet Freezing and Freeze-Substitution. Adv 2018 Jan 29. ric occlusion break surge measure Exp Med Biol. 2018;1074:603–607. ments. J Cataract Refract Surg. 2018 Williams DS, Mouradov D, Jorissen Feb;44(2):231–236. Hendrick AM, Lavine JA, Domalpally A, RN, Newman MR, Amini E, Nickless Kulkarni AD, Ip MS. Propranolol for Pro DK, Teague JA, Fang CG, Palmieri M, Klufas MA, Tsui I, Sadda SR, Hosseini liferative Diabetic Retinopathy. Ophthal Parsons MJ, Sakthianandeswaren A, H, Schwartz SD. Ultrawidefield auto mic Surg Lasers Imaging Retina. 2018 Li S, Ward RL, Hawkins NJ, Faragher I, fluoresence in ABCA4 Stargardt dis Jan 1;49(1):35–40. Jones IT, Gibbs P, Sieber OM. Lympho ease. Retina. 2018 Feb;38(2):403–415. cytic response to tumour and deficient Stark DT, Anderson DMG, Kwong JMK, Romero P, Hirunpatravong P, Alizadeh Patterson NH, Schey KL, Caprioli RM, DNA mismatch repair identify subtypes of stage II/III colorectal cancer associ R, Kim EA, Nouri-Mahdavi K, Morales Caprioli J. Optic Nerve Regeneration E, Law SK, Caprioli J. Trabeculectomy After Crush Remodels the Injury Site: ated with patient outcomes. Gut. 2018 Jan 30. With Mitomycin-C: Outcomes and Risk Molecular Insights From Imaging Mass Factors for Failure in Primary Angle- Spectrometry. Invest Ophthalmol Vis Friedlander AH, Graves LL, Chang TI, closure Glaucoma. J Glaucoma. 2018 Sci. 2018 Jan 1;59(1):212–222. Kawakami KK, Lee UK, Grabich SC, Feb;27(2):101–107. Fang ZT, Zeidler MR, Giaconi JA. Prev Tseng VL, Chlebowski RT, Yu F, Srinivas S, Nittala MG, Hariri A, Pfau M, Cauley JA, Li W, Thomas F, Virnig BA, alence of primary open-angle glaucoma Gasperini J, Ip M, Sadda SR. Quanti Coleman AL. Association of Cata among patients with obstructive sleep apnea. Oral Surg Oral Med Oral Pathol fication of intraretinal hard exudates in ract Surgery With Mortality in Older eyes with diabetic retinopathy by optical Women: Findings from the Women’s Oral Radiol. 2018 Sep;126(3):226–230. Epub 2018 Jan 31. coherence tomography. Retina. 2018 Health Initiative. JAMA Ophthalmol. Feb;38(2):231–236. 2018 Jan 1;136(1):3–10. February 2018 Tam EK, Golchet P, Yung M, DeCroos Chaudhuri Z, Demer JL. Long-term Alizadeh R, Akil H, Tan J, Law SK, FC, Spirn M, Lehmann-Clarke L, Surgical Outcomes in the Sagging Eye Caprioli J. Trabeculectomy Outcomes Ambresin A, Tsui I. Ischemic central Syndrome. Strabismus. 2018 Mar; After Glaucoma Drainage Device retinal vein occlusion in the anti-vascular 26(1):6–10. Epub 2018 Jan 3. Surgery. J Glaucoma. 2018 Feb;27(2): endothelial growth factor era. Retina. Xu D, Lin SR, Bonelli L, Glasgow BJ, 133–139. 2018 Feb;38(2):292–298. Goldberg RA. Orbital granulomatosis Al-Sheikh M, Iafe NA, Phasukkijwatana Caprioli J. Visual Field Assessment with polyangiitis masquerading as N, Sadda SR, Sarraf D. Biomarkers in Children. JAMA Ophthalmol. 2018 invasive fungal sinusitis. Orbit. 2018 of neovascular activity in age-related Feb 1;136(2):162–163. Aug;37(4):309–312. Epub 2018 Jan 5. macular degeneration using optical Chan CK, Sarraf D, Abraham P. Treat coherence tomography angiography. Glasgow BJ, Abduragimov AR. Inter ment outcomes of conventional or Retina. 2018 Feb;38(2):220–230. action of ceramides and tear lipocalin. high-dose ranibizumab for vascularized Biochim Biophys Acta Mol Cell Biol Bates CK, Jagsi R, Gordon LK, Travis E, pigment epithelial detachment based Lipids. 2018 Apr;1863(4):399–408. Epub Chatterjee A, Gillis M, Means O, on lesion subtypes. Eur J Ophthalmol. 2018 Jan 11. Chaudron L, Ganetzky R, Gulati M, 2018 Feb 1:1120672117747034. , Rosenbaum JT. The Chal Fivush B, Sharma P, Grover A, Holland GN Falavarjani KG, Sarraf D, Tsui I. Optical Lautenberger D, Flotte TR. It Is Time for lenge of Blau Syndrome. Am J Ophthal Coherence Tomography Angiography of Zero Tolerance for Sexual Harassment mol. 2018 Mar;187:xviii–xix. Epub 2018 the Macula in Adults With a History of in Academic Medicine. Acad Med. 2018 Jan 12. Preterm Birth. Ophthalmic Surg Lasers Feb;93(2):163–165. Khan MA, Gupta OP, Pendi K, Chiang Imaging Retina. 2018 Feb 1;49(2): A, Vander J, Regillo CD, Hsu J. 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Lim MC, Boland MV, McCannel CA, Van Eps N, Altenbach C, Caro LN, Bokman CL, Ugradar S, Rootman DB. Saini A, Chiang MF, Epley KD, Lum F. Latorraca NR, Hollingsworth SA, Dror Measurement of Medial Wall Bowing Adoption of Electronic Health Records RO, Ernst OP, Hubbell WL. Gi- and and Clinical Associations in Thyroid Eye and Perceptions of Financial and Clinical Gs-coupled GPCRs show different Disease. Ophthalmic Plast Reconstr Outcomes Among Ophthalmologists in modes of G-protein binding. Proc Natl Surg. 2018 Mar 2. the United States. JAMA Ophthalmol. Acad Sci USA. 2018 Mar 6;115(10): 2018 Feb 1;136(2):164–170. 2383–2388. Epub 2018 Feb 20. Radhakrishnan S, Chen PP, Junk AK, Nouri-Mahdavi K, Chen TC. Laser Wang YE, Tseng VL, Yu F, Caprioli J, Essilfie JO, Huynh A,Gorin MB, Sadda Peripheral Iridotomy in Primary Angle Coleman AL. Association of Dietary SR. A case of intraretinal peripapillary Closure: A Report by the American Fatty Acid Intake With Glaucoma in the neovascularization in ABCA4-related Academy of Ophthalmology. Ophthal United States. JAMA Ophthalmol. 2018 retinopathy. Retin Cases Brief Rep. mology. 2018 Jul;125(7):1110–1120. Feb 1;136(2):141–147. 2018 Feb 21. Epub 2018 Mar 2. Gu L, Kwong JMK, Yadegari D, Yu F, Sadda SR, Tuomi LL, Ding B, Fung AE, Morshedian A, Woodruff ML, Fain GL. Caprioli J, Piri N. The effect of celas Hopkins JJ. Macular Atrophy in the Role of recoverin in rod photoreceptor trol on the ocular hypertension-induced HARBOR Study for Neovascular Age- light adaptation. J Physiol. 2018 Apr 15; degeneration of retinal ganglion cells. Related Macular Degeneration. Ophthal 596(8):1513–1526. Epub 2018 Mar 5. Neurosci Lett. 2018 Mar 23;670:89–93. mology. 2018 Jun;125(6):878–886. Epub 2018 Feb 2. Epub 2018 Feb 21. Jampol LM, Glassman AR, Liu D, Aiello LP, Bressler NM, Duh EJ, Quaggin Tam EK, Lonngi M, Demer JL. MRI Borrelli E, Lonngi M, Balasubramanian S, Wells JA, Wykoff CC; Diabetic findings of contralateral oculomotor S, Tepelus TC, Baghdasaryan E, Iafe Retinopathy Clinical Research Network nerve palsy in Parry-Romberg syn NA, Pineles SL, Velez FG, Sarraf D, (Ip MS). Plasma Vascular Endothelial drome. Am J Ophthalmol Case Rep. Sadda SR, Tsui I. Macular microvas Growth Factor Concentrations after 2018 Feb 2;10:81–83. cular networks in healthy pediatric Intravitreous Anti-Vascular Endothelial subjects. Retina. 2018 Feb 22. Growth Factor Therapy for Diabetic Fan W, Uji A, Borrelli E, Singer M, Macular Edema. Ophthalmology. 2018 Sagong M, van Hemert J, Sadda SR. Klufas MA, Tsui I, Sadda SR, Hosseini Jul;125(7):1054–1063. Epub 2018 Precise Measurement of Retinal Vascu H, Schwartz SD. Ultrawidefield Auto- Mar 7. lar Bed Area and Density on Ultra-wide fluorescence in ABCA4 Stargardt Fluorescein Angiography in Normal Disease. Retina. 2018 Feb 28; 38(2): Chae B, Su D, Gal-Or O, Freund KB, Subjects. Am J Ophthalmol. 2018 Apr; 403–415. Sarraf D. Type 3 neovascularisation: 188:155–163. Epub 2018 Feb 8. long-term analysis of visual acuity and March 2018 (Spring) optical coherence tomography anatomi Ye L, Gu L, Caprioli J, Piri N. RNA- Bozkurt TK, Tang Q, Grunstein LL, cal outcomes. Br J Ophthalmol. 2018 binding protein Rbpms is represented in Mar 8. human retinas by isoforms A and C and McCannel TA, Straatsma BR, Miller its transcriptional regulation involves KM. Outcomes of cataract surgery in Friedlander AH, Giaconi JA, Lee UK, Sp1-binding site. Mol Genet Genomics. eyes with ocular melanoma treated Chang TI, Zeidler MR. Obstructive 2018 Aug;293(4):819–830. Epub 2018 with iodine-125 brachytherapy. J Sleep Apnea: An Ill Eye in the Wind. Feb 8. Cataract Refract Surg. 2018 Mar;44(3): J Oral Maxillofac Surg. 2018 Jun;76(6): 287–294. 1143–1144. Epub 2018 Mar 8. Kinori M, Molina I, Hernandez EO, Robbins SL, Granet DB, Coleman AL, Lau LF, Murone C, Williams DS, Glasgow BJ, McCannel TA. Corre Brown SI. The PlusoptiX Photoscreener Standish R, Lee ST, Christophi C, lation of Immunocytochemistry of and the Retinomax Autorefractor as Scott AM, Muralidharan V. Metabolic BRCA1-associated Protein-1 (BAP1) Community-based Screening Devices response evaluation for colorectal With Other Prognostic Markers in Uveal for Preschool Children. Curr Eye Res. liver metastases and correlation to Melanoma. Am J Ophthalmol. 2018 2018 May;43(5):654–658. Epub 2018 pathologic response and tumour May;189:122–126. Epub 2018 Mar 9. Feb 9. markers. ANZ J Surg. 2018 Mar;88(3): E108–E113. Keller KE, Bhattacharya SK, Borrás Golan S, Rootman DB, Lambros V, T, Brunner TM, Chansangpetch S, Goldberg RA. Ocular protrusion in Nusinowitz S, Wang Y, Kim P, Habib S, Clark AF, Dismuke WM, Du Y, Elliott sitting and supine position. Clin Exp Baron R, Conley Y, Gorin M. Retinal MH, Ethier CR, Faralli JA, Freddo TF, Ophthalmol. 2018 Feb 11. Structure in Pre-Clinical Age-Related Fuchshofer R, Giovingo M, Gong H, Macular Degeneration. Curr Eye Res. Gonzalez P, Huang A, Johnstone MA, Ugradar S, Rootman DB. Case Series: 2018 Mar;43(3):376–382. Kaufman PL, Kelley MJ, Knepper PA, Noninflammatory Thyroid Eye Disease. Tseng VL, Coleman AL. Reducing the Kopczynski CC, Kuchtey JG, Kuchtey Ophthalmic Plast Reconstr Surg. 2018 RW, Kuehn MH, Lieberman RL, Feb 16. Burden of Unilateral Vision Impairment and Blindness in Australia. JAMA Oph Lin SC, Liton P, Liu Y, Lütjen-Drecoll E, Falavarjani KG, Habibi A, Khorasani MA, thalmol. 2018 Mar 1;136(3):248–249. Mao W, Masis-Solano M, McDonnell F, Anvari P, Sadda SR. Time course of McDowell CM, Overby DR, Pattabira changes in optic disk neovascularization Yun J, Xiao T, Zhou L, Beuerman RW, man PP, Raghunathan VK, Rao PV, Rhee after a single intravitreal bevacizumab Li J, Zhao Y, Hadayer A, Zhang X, Sun DJ, Chowdhury UR, Russell P, Samples injection. Retina. 2018 Feb 19. D, Kaplan HJ, Shao H. Local S100A8 JR, Schwartz D, Stubbs EB, Tamm ER, Levels Correlate With Recurrence of Tan JC, Toris CB, Torrejon KY, Vranka Experimental Autoimmune Uveitis and JA, Wirtz MK, Yorio T, Zhang J, Zode Promote Pathogenic T Cell Activity. GS, Fautsch MP, Peters DM, Acott TS, Invest Ophthalmol Vis Sci. 2018 Mar 1; Stamer WD. Consensus recommen 59(3):1332–1342. dations for trabecular meshwork cell

142 Stein Eye Institute | Appendices Publications isolation, characterization and culture. Tay C, Liu YH, Kanellakis P, Kallies A, Sears CM, Nittala MG, Jayadev C, Exp Eye Res. 2018 Jun;171:164–173. Li Y, Cao A, Hosseini H, Tipping P, Verhoek M, Fleming A, van Hemert Epub 2018 Mar 9. Toh BH, Bobik A, Kyaw T. Follicular J, Tsui I, Sadda SR. Comparison of B Cells Promote Atherosclerosis via Subjective Assessment and Precise Garcia GA, Khoshnevis M, Yee KMP, T Cell-Mediated Differentiation Into Quantitative Assessment of Lesion Nguyen JH, Nguyen-Cuu J, Sadun AA, Plasma Cells and Secreting Pathogenic Distribution in Diabetic Retinopathy. Sebag J. The effects of aging vitreous Immunoglobulin G. Arterioscler Thromb JAMA Ophthalmol. 2018 Apr 1;136(4): on contrast sensitivity function. Graefes Vasc Biol. 2018 May;38(5):e71–e84. 365–371. Arch Clin Exp Ophthalmol. 2018 May; Epub 2018 Mar 29. 256(5):919–925. Epub 2018 Mar 13. Williamson TJ, Jorge-Miller A, Clark RA, Demer JL. The Globe’s McCannel TA, Beran TM, Stanton AL. Peng Y, Baulier E, Ke Y, Young A, Eccentric Rotational Axis: Why Medial Sociodemographic, Medical, and Psy Ahmedii NB, Schwartz SD, Farber DB. Rectus Surgery Is More Potent than chosocial Factors Associated With Sup Human embryonic stem cells extra Lateral Rectus Surgery. Ophthalmol portive Care Needs in Adults Diagnosed cellular vesicles and their effects on ogy. 2018 Aug;125(8):1234–1238. Epub With Uveal Melanoma. JAMA Ophthal immortalized human retinal Muller cells. 2018 Mar 30. mol. 2018 Apr 1;136(4):356–363. PLos One. 18 Mar 14;13(3):e0194004. Wu CM, Wu AM, Greenberg PB, Yu F, Shin A, Park J, . Opto- April 2018 Demer JL Lum F, Coleman AL. Frequency of mechanical characterization of sclera by Chen X, Sanfilippo CJ, Nagiel A, Bevacizumab and Ranibizumab Injec polarization sensitive optical coherence Hosseini H, Mitchell D, McCannel CA, tions for Diabetic Macular Edema in tomography. J Biomech. 2018 Apr Schwartz SD, McCannel TA. Early Medicare Beneficiaries. Ophthalmic 27;72:173–179. Epub 2018 Mar 15. Detection of Retina Hemangioblasto Surg Lasers Imaging Retina. 2018 mas in von Hippel-Lindau Disease Using Borrelli E, Mastropasqua R, Senatore Apr 1;49(4):241–244. Ultra-Widefield FluorsceinAngiography. A, Palmieri M, Toto L, Sadda SR, Retina. 2018 Apr; 38(4):748–754 . Baghdasaryan E, Tepelus TC, Vickers Mastropasqua L. Impact of Choriocapil LA, Huang P, Chopra V, Sadda SR, laris Flow on Multifocal Electroreti González-Quevedo A, Santiesteban- Lee OL. Assessment of Corneal nography in Intermediate Age-Related Freixas R, Eells JT, Lima L, Sadun AA. Changes Associated with Topical Macular Degeneration Eyes. Invest Cuban Epidemic Neuropathy: Insights Antiglaucoma Therapy Using in vivo Ophthalmol Vis Sci. 2018 Mar 20;59(4): into the Toxic-Nutritional Hypothesis Confocal Microscopy. Ophthalmic Res. AMD25–AMD30. through International Collaboration. 2018 Apr 7. MEDICC Rev. 2018 Apr;20(2):27–31. Garrity ST, , Freund KB, Sarraf D Sadda Lambert SR, Kraker RT, Pineles SL, SR. Multimodal Imaging of Nonneovas Khan MA, Durrani AK, Hsu J, Regillo Hutchinson AK, Wilson LB, Galvin JA, cular Age-Related Macular Degenera CD. 27-Gauge Vitrectomy Wound Integ VanderVeen DK. Contact Lens Correc tion. Invest Ophthalmol Vis Sci. 2018 rity: A Randomized Pilot Study Com tion of Aphakia in Children: A Report by Mar 20;59(4):AMD48–AMD64. Review. paring Angled Versus Straight Entry in the American Academy of Ophthalmol Fluid-Filled Vitrectomized Eyes. Retina. Ghosh S, Shang P, Terasaki H, ogy. Ophthalmology. 2018 Sep;125(9): 2018 Apr;38(4):678–683. Stepicheva N, Hose S, Yazdankhah M, 1452–1458. Epub 2018 Apr 7. Weiss J, Sakamoto T, Bhutto IA, Xia S, Pichi F, Freund KB, Ciardella A, Morara Glasgow BJ, Abduragimov AR. Ligand Zigler JS Jr, Kannan R, Qian J, Handa M, Abboud EB, Ghazi N, Dackiw C, binding studies by high speed centri JT, Sinha D. A Role for βA3/A1-Crystallin Choudhry N, Souza EC, Cunha LP, fugal precipitation and linear spectral in Type 2 EMT of RPE Cells Occurring in Arevalo JF, Liu TYA, Wenick A, He L, summation using ultraviolet-visible Dry Age-Related Macular Degeneration. Villarreal G Jr, Neri P, Sarraf D. Con absorption spectroscopy. MethodsX. Invest Ophthalmol Vis Sci. 2018 Mar genital Retinal Macrovessel and the 2018 Apr 17;5:345–351. 20;59(4):AMD104–AMD113. Association of Retinal Venous Malfor mations With Venous Malformations Cervantes AE, Gee KM, Whiting MF, Sarria I, Cao Y, Wang Y, Ingram NT, of the Brain. JAMA Ophthalmol. 2018 Frausto RF, Aldave AJ. Confirmation Orlandi C, Kamasawa N, Kolesnikov AV, Apr 1;136(4):372–379. and refinement of the heterozygous Pahlberg J, Kefalov VJ, Sampath AP, deletion of the small leucine-rich proteo Martemyanov KA. LRIT1 Modulates Scott IU, VanVeldhuisen PC, Ip MS, glycans associated with posterior amor Adaptive Changes in Synaptic Commu Blodi BA, Oden NL, Altaweel M, phous corneal dystrophy. Ophthalmic nication of Cone Photoreceptors. Cell Berinstein DM; SCORE2 Investigator Genet. 2018 Aug;39(4):419–424. Epub Rep. 2018 Mar 27;22(13):3562–3573. Group. Comparison of Monthly vs Treat- 2018 Apr 19. and-Extend Regimens for Individuals Parker DM, Angeles-Han ST, Stanton With Macular Edema Who Respond Dastiridou A, Marion K, Niemeyer M, AL, Holland GN. Chronic Anterior Uve Well to Anti-Vascular Endothelial Francis B, Sadda S, Chopra V. Pilot itis in Children: Psychosocial Challenges Growth Factor Medications: Secondary Study of the Effects of Ambient Light for Patients and Their Families. Am Outcomes From the SCORE2 Random Level Variation on Spectral Domain J Ophthalmol. 2018 Jul;191:xvi–xxiv. ized Clinical Trial. JAMA Ophthalmol. 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Khanani AM, Eichenbaum D, Peterson JS, Rockwell K Jr, Scott IU, Park KH, Lee JW, Kim JM, Nouri- Schlottmann PG, Tuomi L, Sarraf D. Ip MS, VanVeldhuisen PC, Blodi BA; Mahdavi K, Caprioli J. Bruch’s mem Optimal management of pigment SCORE2 Investigator Group. Long-term brane opening-minimum rim width and epithelial detachments in eyes with physical stability, sterility, and anti-vegf visual field loss in glaucoma: a broken neovascular age-related macular degen bioactivity of repackaged bevacizumab stick analysis. Int J Ophthalmol. 2018 eration. Retina. 2018 Apr 24. in 2-ml glass vials. Retina. 2018 May 9. May 18;11(5):828–834. Kwon S, Wykoff CC, Brown DM, Shao J, Abdelghani M, Shen G, Cao S, Sreekumar PG, Li Z, Wang W, Spee C, van Hemert J, Fan W, Sadda SR. Williams DS, van Hest JCM. Erythro Hinton DR, Kannan R, MacKay JA. Changes in retinal ischaemic index cyte Membrane Modified Janus Poly Intra-vitreal αB crystallin fused to correlate with recalcitrant macular meric Motors for Thrombus Therapy. elastin-like polypeptide provides neuro oedema in retinal vein occlusion: ACS Nano. 2018 May 22;12(5):4877– protection in a mouse model of age- WAVE study. Br J Ophthalmol. 2018 4885. Epub 2018 May 9. related macular degeneration. J Control Aug;102(8):1066–1071. Epub 2018 Release. 2018 Aug 10;283:94–104. Apr 26. Abdelfattah NS, Hariri AH, Al-Sheikh M, Epub 2018 May 18. Pitetta S, Ebraheem A, Wykoff CC, Kim JH, Caprioli J. Intraocular Pressure Sadda SR; TREX-AMD Study Group. Balducci N, Cascavilla ML, Ciardella A, Fluctuation: Is It Important? J Oph Topographic Correspondence of Macu La Morgia C, Triolo G, Parisi V, Bandello thalmic Vis Res. 2018 Apr–Jun;13(2): lar Atrophy With Choroidal Neovascu F, Sadun AA, Carelli V, Barboni P. 170–174. Review. larization in Ranibizumab-treated Eyes Peripapillary vessel density changes in of the TREX-AMD Trial. Am J Ophthal Leber’s hereditary optic neuropathy: a May 2018 mol. 2018 Aug;192:84–90. Epub 2018 new biomarker. Clin Exp Ophthalmol. Dastiridou A, Chopra V. Potential appli May 12. 2018 May 22. cations of optical coherence tomogra Zheng C, Yu F, Tseng VL, Lum F, Fain G, Sampath AP. Rod and cone phy angiography in glaucoma. Curr Opin Coleman AL. Risk of Glaucoma Surgery interactions in the retina. F1000Res. Ophthalmol. 2018 May;29(3):226–233. After Corneal Transplant Surgery in 2018 May 23;7. Faculty Rev-657. Review. Medicare Patients. Am J Ophthalmol. Review. Luo H, Yang H, Gardiner SK, Hardin 2018 Aug;192:104–112. Epub 2018 May 12. Danesh J, Ugradar S, Goldberg R, C, Sharpe GP, Caprioli J, Demirel S, Rootman DB. A novel technique for Girkin CA, Liebmann JM, Mardin CY, Tseng VL, Lee J, Yu F, Sirsy O, the measurement of eyelid contour to Quigley HA, Scheuerle AF, Fortune B, Coleman AL. Associations between compare outcomes following Muller’s Chauhan BC, Burgoyne CF. Factors factors related to atopic disease and muscle-conjunctival resection and Influencing Central Lamina Cribrosa glaucoma in the National Health and external levator resection surgery. Eye Depth: A Multicenter Study. Invest Nutrition Examination Survey. Eur J (Lond). 2018 Sep;32(9):1493–1497. Ophthalmol Vis Sci. 2018 May 1;59(6): Ophthalmol. 2018 Sep;28(5):598–606. Epub 2018 May 24. 2357–2370. Epub 2018 May 14. Angeles-Han ST, Lo MS, Henderson Zhang XM, Hashimoto T, Tang R, Yang Pfau M, Lindner M, Goerdt L, Thiele LA, Lerman MA, Abramson L, Cooper XJ. Elevated expression of human S, Nadal J, Schmid M, Schmitz- AM, Parsa MF, Zemel LS, Ronis T, bHLH factor ATOH7 accelerates cell Valckenberg S, Sadda SR, Holz FG, Beukelman T, Cox E, Sen HN, Holland cycle progression of progenitors and Fleckenstein M; Fundus Autofluores GN, Brunner HI, Lasky A, Rabinovich enhances production of avian retinal cence in Age-Related Macular Degen CE; Juvenile Idiopathic Arthritis ganglion cells. Sci Rep. 2018 May 1; eration Study Group. Prognostic value Disease-Specific Uveitis Subcommittee 8(1):6823. of shape-descriptive factors for the of Childhood Arthritis Rheumatology Esteve-Rudd J, Hazim RA, Diemer T, progression of geographic atrophy sec Research Alliance. Childhood Arthritis Paniagua AE, Volland S, Umapathy A, ondary to age-related macular degen and Rheumatology Research Alliance Williams DS. Defective phagosome eration. Retina. 2018 May 16. consensus treatment plans for juvenile idiopathic arthritis-associated and idio motility and degradation in cell non Liang D, Woo JI, Shao H, Born WK, autonomous RPE pathogenesis of a pathic chronic anterior uveitis. Arthritis O’Brien RL, Kaplan HJ, Sun D. Ability Care Res (Hoboken). 2018 May 28. dominant macular degeneration. Proc of γδ T cells to modulate the Foxp3 Natl Acad Sci USA. 2018 May 22; T cell response is dependent on Uji A, Balasubramanian S, Lei J, 115(21):5468–5473. Epub 2018 May 7. adenosine. PLoS One. 2018 May 17; Baghdasaryan E, Al-Sheikh M, Borrelli Nittala MG, Song YE, Sardell R, Adams 13(5):e0197189. E, Sadda SR. Multiple enface image averaging for enhanced optical coher LD, Pan S, Velaga SB, Horst V, Dana D, Baghdasaryan E, Huang X, Marion KM, Caywood L, Laux R, Fuzzell D, Fuzzell ence tomography angiography imaging. Tepelus TC, Bagherinia H, Sadda SR, Acta Ophthalmol. 2018 May 31. S, Scott WK, Cooke Bailey JN, Igo RP Hsu HY. Reproducibility of Central Jr, Haines J, Pericak-Vance MA, Sadda Corneal Thickness Measurements in Rafaelof M, Mustak H, Rootman DB. SR, Stambolian D. Amish Eye Study: Normal Eyes Using the Zeiss Cirrus Anomalous Sphenoid Diploe Vein: Case Baseline Spectral Domain Optical 5000 HD-OCT and Pentacam HR. Open Report Highlighting the Value of Careful Coherence Tomography Characteristics Ophthalmol J. 2018 May 18;12:72–83. CT Evaluation Prior to Decompression of Age-Related Macular Degeneration. Surgery. Ophthalmic Plast Reconstr Retina. 2018 May 9. Surg. 2018 May/Jun;34(3):e74–e75.

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June 2018 (Summer) Hwang CJ, Mustak H, Gupta AA, Pineles SL, Velez FG. Isolated Ocular Leung VC, Fung SSM, Muni R, Ali A. Ramos RM, Goldberg RA, Duckwiler Motor Nerve Palsies. J Binocul Vis Ocul Phacomorphic Angle-closure Following GR. Role of Retrobulbar Hyaluronidase Motil. 2018 Jul–Sep;68(3):70–77. Epub Silicone Oil Tamponade in a Pediatric in Filler-Associated Blindness: Evalua 2018 Jun 21. tion of Fundus Perfusion and Electroret Patient. J Glaucoma. 2018 Jun;27(6): Hosseini H, Yi L, Kanellakis P, Cao A, e106–e109. inogram Readings in an Animal Model. Ophthalmic Plast Reconstr Surg. 2018 Tay C, Peter K, Bobik A, Toh BH, Kyaw Torres LA, Vianna JR, Jarrar F, Sharpe Jun 5. T. Anti-TIM-1 Monoclonal Antibody GP, Araie M, Caprioli J, Demirel S, (RMT1–10) Attenuates Atherosclerosis Girkin CA, Hangai M, Iwase A, Prasad P. Injury Around the Eye. By Expanding IgM-producing B1a Cells. Liebmann JM, Mardin CY, Nakazawa T, JAMA. 2018 Jun 5;319(21):2244. J Am Heart Assoc. 2018 Jun 23;7(13). pii: e008447. Quigley HA, Scheuerle AF, Sugiyama Borrelli E, Balasubramanian S, Triolo K, Tanihara H, Tomita G, Yanagi Y, G, Barboni P, Sadda SR, Sadun AA. Burgoyne CF, Chauhan BC. Protruded Topographic Macular Microvascular retinal layers within the optic nerve Changes and Correlation With Visual head neuroretinal rim. Acta Ophthalmol. Loss in Chronic Leber Hereditary Optic 2018 Jun;96(4):e493–e502. Neuropathy. Am J Ophthalmol. 2018 Holland GN, Rimoin AW. The Ophthal Aug;192:217–228. Epub 2018 Jun 7. mic Sequelae of Ebola. JAMA Ophthal Schönbach EM, Strauss RW, Kong X, mol. 2018 Jun 1;136(6):693–694. Muñoz B, Ibrahim MA, Sunness JS, Holz FG, Sadda SR, Busbee B, Birch DG, Hahn GA, Nasser F, Zrenner Chew EY, Mitchell P, Tufail A, Brittain C, E, Sadda SR, West SK, Scholl HPN; Ferrara D, Gray S, Honigberg L, Martin ProgStar Study Group (Ip MS). Longitu J, Tong B, Ehrlich JS, Bressler NM; dinal Changes of Fixation Location and Chroma and Spectri Study Investiga Stability Within 12 Months in Stargardt tors. Efficacy and Safety of Lampali Disease: ProgStar Report No. 12. Am J zumab for Geographic Atrophy Due to Ophthalmol. 2018 Sep;193:54–61. Epub Age-Related Macular Degeneration: 2018 Jun 8. Chroma and Spectri Phase 3 Random Wu AM, Wu CM, Greenberg PB, Yu F, ized Clinical Trials. JAMA Ophthalmol. Lum F, Coleman AL. The use of beva 2018 Jun 1;136(6):666–677. cizumab and ranibizumab for branch Suh SY, Clark RA, Demer JL. Optic retinal vein occlusion in Medicare ben Nerve Sheath Tethering in Adduction eficiaries. Am J Ophthalmol Case Rep. Occurs in Esotropia and Hypertropia, 2018 Jun 19;11:105–108. But Not in Exotropia. Invest Ophthalmol Fujinami K, Strauss RW, Chiang JP, Vis Sci. 2018 Jun 1;59(7):2899–2904. Audo IS, Bernstein PS, Birch DG, Tepelus TC, Hariri AH, Balasubramanian Bomotti SM, Cideciyan AV, Ervin S, Sadda SR. Reproducibility of Macu AM, Marino MJ, Sahel JA, Mohand- lar Thickness Measurements in Eyes Said S, Sunness JS, Traboulsi EI, Affected by Dry Age-Related Macular West S, Wojciechowski R, Zrenner Degeneration From Two Different E, Michaelides M, Scholl HPN; On SD-OCT Instruments. Ophthalmic Surg behalf of the ProgStar Study Group; Lasers Imaging Retina. 2018 Jun 1; ProgStar Study Group (Ip MS). Detailed 49(6):410–415. genetic characteristics of an interna tional large cohort of patients with Borrelli E, Nittala MG, Abdelfattah NS, Stargardt disease: ProgStar study report Lei J, Hariri AH, Shi Y, Fan W, Cozzi 8. Br J Ophthalmol. 2018 Jun 20. pii: M, Sarao V, Lanzetta P, Staurenghi bjophthalmol-2018-312064. G, Sadda SR. Comparison of short- wavelength blue-light autofluorescence Aravena C, Dyk DW, Thorne A, Fanney and conventional blue-light auto D, Miller KM. Aqueous volume loss fluorescence in geographic atrophy. associated with occlusion break surge Br J Ophthalmol. 2018 Jun 5. pii: in phacoemulsifiers from 4 different bjophthalmol-2018-311849. manufacturers. J Cataract Refract Surg. 2018 Jul;44(7):884–888. Epub 2018 He Z, Sun X, Ma Z, Fu J, Huang B, Liu F, Jun 21. Chen Y, Deng T, Han X, Sun D, Lan C. Heat shock protein 70 protects mouse Liang D, Shao H, Born WK, O’Brien RL, against post-infection irritable bowel Kaplan HJ, Sun D. High level expres syndrome via up-regulating intestinal sion of A2ARs is required for the γδ T cell’s Th17 response. Cell Biosci. enhancing function, but not for the 2018 Jun 5;8:38. inhibiting function, of γδ T cells in the autoimmune responses of EAU. PLoS One. 2018 Jun 21;13(6):e0199601.

Appendices | Stein Eye Institute 145 Appendices Giving Opportunities

The UCLA Stein Eye Institute is a vision-science campus dedicated to the preservation and restoration of vision through its global programs in innovative research, quality patient care, and multidisciplinary, integrative education, all with community outreach. UCLA’s vision scientists are extending the boundaries of current knowledge and approaching the goal for a lifetime of good vision for everyone, due in large part to a strong tradition of philanthropy from private sources.

Contributions from individuals, foundations, and corporations help underwrite exemplary patient-care programs, innovative scientific advances, key community engagement, and the highest-quality training and education. The Institute offers a variety of giving options to those who wish to contribute to this tradition of excellence.

How to Support the UCLA Stein Eye Institute

Direct Gifts Securities Bequests Direct gifts––whether by cash, check, Gifts of appreciated securities are tax Making a gift through your will or living or credit card––are critically important to deductible at their full market value. In trust gives you the immediate satisfac Stein Eye because the gifts can be put most cases, appreciation in the value of tion of creating a lasting and personal to work immediately, increasing their the security benefits the University and legacy that ensures Stein Eye’s future impact and extending their reach. is not taxable to the donor. and costs nothing now.

Endowments Matching Gifts Charitable Gift Annuity A gift of an endowment demonstrates a Many corporations have demonstrated In exchange for a gift of cash or appre long-term commitment, since the fund their support by matching or multiply ciated securities, you can receive fixed is maintained in perpetuity. A portion of ing their employees’ gifts up to a set income for life and an immediate chari the annual investment income is used amount. Before making a gift, you may table income tax deduction. In addition, to support clinical, educational, and want to ask whether your employer a portion of the annuity payments is scientific initiatives and the remaining participates in a matching gift program. tax-free. investment yield is returned to principal, Certain restrictions apply to matching thus, over the years, the fund can grow gifts. Please consult your company’s Qualified Retirement Plans and provide continuous support. personnel office. Naming The UCLA Foundation as a ben eficiary of some or all of your qualified An endowment serves as an enduring Real Estate retirement plan may help you minimize legacy as it can bear the donor’s name Real estate (your primary residence, taxes and maximize your philanthropic or honor a loved one. Giving opportuni vacation home, commercial property, impact, while leaving to your loved ties exist for endowed chairs, endowed or land) is an asset that you can lever ones, assets that are less taxed. fellowships, and endowed funds for age in a variety of ways to support research, education, and patient care. the Institute while reducing taxes and Tribute Gifts These funds can be made payable for eliminating the burden of maintaining or Contributions may be made in memory, up to five years. selling your property. You can also use honor, or celebration of a loved one, or Pledges real estate to fund gifts that provide you to commemorate a special occasion. with an income stream for life. Donations can be used for unrestricted A pledge is a formal statement of program support or be directed to any intention to make a gift. Donors who area of the Institute. seek to defer the bulk of their giving until a future date, or who want to give via installments over time, may use Your Gift Can Make a Difference this giving strategy. A pledge may be However you choose to support the Institute, you will be embarking on a followed by an immediate gift or may partnership with one of the world’s preeminent eye research centers. Such an simply confirm your intention to make investment will greatly expand our understanding of the causes of eye diseases, a gift in the future. Pledges are typi expose alternative treatment options, and ultimately prevent blindness. cally made in concert with a preliminary first installment and provide a source For information on how to incorporate the UCLA Stein Eye Institute into your of consistent and dependable funding. estate and retirement planning, or to make a gift of any kind, please contact: This method often allows donors to UCLA Stein Eye Institute give more generously than they may Development Office have originally considered. 100 Stein Plaza, Room 1-124 Los Angeles, California 90095-7000 Phone: (310) 206-6035 Fax: (310) 794-1665 [email protected] Stein Eye Institute ANNUAL REPORT

July 1, 2017– June 30, 2018

DIRECTOR Bartly J. Mondino, MD

MANAGING EDITOR Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 [email protected]

PUBLICATION COMMITTEE Anthony C. Arnold, MD Kevin M. Miller, MD Alapakkam P. Sampath, PhD Alfredo A. Sadun, MD, PhD M. Gail Summers

CONTRIBUTING EDITORS Teresa Closson Susan Ito Sarah Johnson Peter J. López Ellen Pascual Debbie Sato

CONTRIBUTING WRITERS Dan Gordon Harlan Lebo

PHOTOGRAPHY Reed Hutchinson J. Charles Martin Robin Weisz

DESIGN Robin Weisz/Graphic Design

PRINTING Colornet Press

To view the Annual Report online, visit: www.uclahealth.org/Eye/annual-report

For more information about the Institute, see: www.uclahealth.org/eye/

Benefactor: Benefactor: Uncle Claude Annual Report 2017–2018 Uncle Claude

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ANNUAL REPORT 2017–2018ANNUAL REPORT Annual Report 2016–2017

THE ONLY BARRIER TO A CURE Benefactor: Benefactor: Uncle Claude IS ACCESS Uncle Claude TO CARE.

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