(G-CSF) in Patients with Substance Use Disorders and Comorbid
www.nature.com/scientificreports OPEN Plasma concentrations of granulocyte colony‑stimulating factor (G‑CSF) in patients with substance use disorders and comorbid major depressive disorder Sandra Torres Galván1,2,3,10, María Flores‑López1,2,4,10, Pablo Romero‑Sanchiz1,2,5, Nerea Requena‑Ocaña1,2, Oscar Porras‑Perales1,2,4,6, Raquel Nogueira‑Arjona1,2,5, Fermín Mayoral1,2, Pedro Araos1,2,4, Antonia Serrano1,2, Roberto Muga7,8, Francisco Javier Pavón1,2,6,9*, Nuria García‑Marchena3,7* & Fernando Rodríguez de Fonseca1,2,3* Granulocyte colony–stimulating factor (G‑CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G‑CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G‑CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary‑care settings. Participants were assessed based on DSM‑IV‑TR criteria, and a blood sample was collected to examine the plasma concentrations of G‑CSF. G‑CSF concentrations were negatively correlated with age in the entire sample (r = − 0.233, p < 0.001) but not in the patients with MDD.
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