Association of a Notch 3 gene polymorphism with migraine susceptibility Author Menon, Saras, Cox, Hannah, Kuwahata, Melissa, Quinlan, Sharon, MacMillan, J, Haupt, Larisa, Lea, Rodney, Griffiths, Lyn Published 2010 Journal Title Cephalalgia DOI https://doi.org/10.1177/0333102410381143 Copyright Statement © 2010 International Headache Society. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. Downloaded from http://hdl.handle.net/10072/36796 Griffith Research Online https://research-repository.griffith.edu.au Association of a Notch 3 gene polymorphism with migraine susceptibility S. Menon1, H.C. Cox 1, M. Kuwahata1 , S. Quinlan1 , J. C. MacMillan 2 , L. M. Haupt1 , R.A. Lea 1,3, and L. R. Griffiths 1 1Genomics Research Centre, Griffith Institute of Health and Medical Research, Griffith University Gold Coast, PMB 50, Gold Coast Mail Centre, Queensland, Australia, 4215 2Department of Medicine, University of Queensland Graduate School of Medicine, and Queensland Institute of Medical Research, Herston, Brisbane, Australia 3Institute of Environmental Science and Research, 34 Kenepuru Drive, Porirua Wellington, New Zealand Communicating Author: Professor Lyn Griffiths Genomics Research Centre Griffith Institute of Health and Medical Research Griffith University, Gold Coast Queensland, Australia, 4215 Email:
[email protected] Telephone: +61-7-55528664 Fax: +61-7-55948908 Abstract Cerebral Autosomal Dominant Arteriopathy with Sub cortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4 respectively of the Notch 3 gene in migraine.