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DISSERTATION the Role of Rim1α in Synaptic Plasticity at the Cerebellar

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DISSERTATION the Role of Rim1α in Synaptic Plasticity at the Cerebellar Aus dem Neurowissenschaftlichen Forschungszentrum der Medizinischen Fakultät Charité – Universitätsmedizin Berlin DISSERTATION The Role of RIM1! in Synaptic Plasticity at the Cerebellar Parallel Fiber zur Erlangung des akademischen Grades Doctor of Philosophy (PhD) im Rahmen des International Graduate Program Medical Neurosciences vorgelegt der Medizinischen Fakultät Charité – Universitätsmedizin Berlin von Michael Kintscher aus Braunschweig Datum der Promotion: 22.06.2014 !"#$%!&!'((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((')! *+!,--.#/,!!+#0'(((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((('1! 2! &#34$5+63&$#'((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((('7! 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A)/%.+9%'D+^'&)?!###########################################################################################################################################!""<! <#F! A,D)(C+%E?-%)/9!########################################################################################################################################!""F! 2 Synopsis Synaptic plasticity is a core feature of neuronal communication. It describes the activity- dependent change of the strength of synaptic transmission. Dependent on the duration of the transmission alteration synaptic plasticity is commonly divided into short-term and long-term plasticity. Whereas long-term plasticity is based on molecular changes at the presynaptic and/or postsynaptic site, factors influencing short-term plasticity are predominantly located at the presynapse. There, basic synaptic transmission and activity-dependent plasticity are governed at the active zone. This is a presynaptic plasma membrane patch with a complex protein network where vesicles are docked and primed, meaning that the required release
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